text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the influences of epinephrine and norepinephrine on the young healthy adult , the older healthy adult and on the patient with cardiac disease have been investigated by means of the systolic time interval ( sti ) method and echocardiography . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
18,
29
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} |
in drinking waters from boreholes in boennerup strand , denmark , fluoride concentrations ranged with time from 1.4 to 2.4 ppm , the variations being unrelated to climate or precipitation , while little variation in fluoride concentrations was found in water from boreholes in either roedvig or egens , denmark . | NA | {
"id": "C0599638",
"name": "drinking waters",
"pos": [
3,
18
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
253,
258
]
} |
these mutant proteins have been shown to have conformations that are closely similar to that of the wild type protein . | NA | {
"id": "C1564139",
"name": "mutant proteins",
"pos": [
6,
21
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
110,
117
]
} |
the authors identify the radiologic features of progressive atelectasis induced under conditions of reduced lung volume . | NA | {
"id": "C0004144",
"name": "atelectasis",
"pos": [
60,
71
]
} | {
"id": "C0024115",
"name": "conditions of",
"pos": [
86,
99
]
} |
we previously have described a model of in vitro herpes simplex virus ( hsv ) latency in which latent infection was ( i ) established with human leukocyte interferon ( ifn-alpha ) in combination with ( e ) -5- ( 2-bromovinyl ) -2'-deoxyuridine ( bvdu ) or 9- [ ( 2-hydroxyethoxy ) methyl ] guanine ( acyclovir ) ; | NA | {
"id": "C0018321",
"name": "guanine",
"pos": [
290,
297
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
300,
309
]
} |
two dogs had a second avulsion fracture at the proximal margin of the articular surface , where the palmar ulnocarpal ligament inserts ( type ii ) , and 2 dogs had a second fracture at the caudal end of the bone at the insertion of the accessoriometacarpal ligaments ( type iii ) . | NA | {
"id": "C0332758",
"name": "avulsion",
"pos": [
22,
30
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
173,
181
]
} |
the possibility of selective killing of transformed cells in a mixed population of untransformed and transformed cells was examined using a cell culture system of rat 3y1 fibroblasts ( parental 3y1 cells , 3y1 cells transformed with either sv40 , polyoma virus , rous avian sarcoma virus , e1a gene of adenovirus type 12 , or h-v-ras oncogene ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
171,
182
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
210,
215
]
} |
a comparison of culture media and conditions for optimal production of both cytotoxic and cytotonic enterotoxins showed that brucella broth incubated under microaerobic conditions for 24 h at 42 degrees c was suitable for both toxins . | NA | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
100,
112
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
227,
233
]
} |
the segregation of dna-binding proteins within bi and bii correlates with their distinct protein profiles and suggests that these vesicles may play different roles . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
19,
39
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
89,
96
]
} |
although the dna-binding proteins expressed in bii may influence the nuclease-resistant export of plasmids within bii vesicles , the bi 11-kda protein may bind transforming dna . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
13,
33
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
143,
150
]
} |
in growing cultures of escherichia coli , simultaneous inhibition of penicillin-binding proteins 1a and 1b ( pbps 1 ) by a beta-lactam efficiently induces cell lysis . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
69,
79
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
123,
134
]
} |
specific inhibition of pbps 1 with the beta-lactam cefsulodin resulted in a delayed onset of lysis which was coincident in time with the resumption of cell division . | NA | {
"id": "C0030842",
"name": "pbps 1",
"pos": [
23,
29
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
39,
50
]
} |
the enzyme activity was shown to be completely insensitive to feedback inhibition by cobalamin and corrinoid intermediates tested at physiological concentration . | NA | {
"id": "C0042845",
"name": "cobalamin",
"pos": [
85,
94
]
} | {
"id": "C1256766",
"name": "corrinoid",
"pos": [
99,
108
]
} |
the rpon mutation in p. putida affected the utilization by this organism of nitrate , urea , and uncharged amino acids , namely , alanine , glycine , isoleucine , leucine , and serine , as nitrogen sources . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
107,
118
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
130,
137
]
} |
the rpon mutation in p. putida affected the utilization by this organism of nitrate , urea , and uncharged amino acids , namely , alanine , glycine , isoleucine , leucine , and serine , as nitrogen sources . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
107,
118
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
140,
147
]
} |
naringenin accumulation was nonsaturable , highly reversible , and not inhibited by the presence of other flavonoids or the metabolic inhibitors potassium cyanide , sodium azide , 2,4-dinitrophenol , and carbonyl cyanide m-chlorophenylhydrazone . | NA | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
145,
162
]
} | {
"id": "C0010505",
"name": "cyanide",
"pos": [
213,
220
]
} |
in the reductive secondary amine-forming reaction with nadh as a cofactor , the enzyme utilized l-amino acids such as l-methionine , l-isoleucine , l-valine , l-phenylalanine , l-leucine , l-alanine , and l-threonine as amino donors and alpha-keto acids such as pyruvate , oxaloacetate , glyoxylate , and alpha-ketobutyrate as amino acceptors . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
98,
103
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
189,
198
]
} |
a phorbol ester , 12-o-tetradecanoylphorbol 13-acetate ( tpa ) , induced the cleavage of nuclear dna at linker regions in cultured mouse thymocytes . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
2,
15
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
18,
54
]
} |
this is the report of evidence that two genes controlling the expression of carbohydrates in glycoconjugates are closely linked and the first to suggest that some genes controlling the expression of carbohydrates may be clustered . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
93,
108
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
199,
212
]
} |
as gp-2 carbohydrate was found to contain 3 mol each of the two types of terminal galnac-containing units , both were nominated as possible components of the io4- oxidation-sensitive epitopes which are responsible for the allergenic activity in gp-2 and its mother antigen , gi-rep . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
183,
191
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
265,
272
]
} |
as gp-2 carbohydrate was found to contain 3 mol each of the two types of terminal galnac-containing units , both were nominated as possible components of the io4- oxidation-sensitive epitopes which are responsible for the allergenic activity in gp-2 and its mother antigen , gi-rep . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
222,
232
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
265,
272
]
} |
a 5'-n-ethylcarboxamido [ 3h ] adenosine ( [ 3h ] neca ) binding site of mouse mastocytoma p815 cell membranes has been purified approximately 100-fold by affinity chromatography . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
31,
40
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
50,
54
]
} |
this adenosine binding site , which has a similar specificity to that of the a2 adenosine receptor , was absorbed on neca-linked sepharose 6b and eluted with neca . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
5,
14
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
158,
162
]
} |
its amino acid composition was asx 1 , thr 1 , ser 1 , glx 2 , pro 1 , gly 1 , ala 1 , val 1 , ile 1 , and leu 2 . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
71,
74
]
} |
the order of effectiveness of anions was cl- greater than br- greater than i- approximately no3- . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
30,
36
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
84,
85
]
} |
heterologous nucleic acids ( native dna , denatured dna , and trna ) exerted only a marginal effect on transfection with a viral replicative-form dna . | NA | {
"id": "C0028606",
"name": "nucleic",
"pos": [
13,
20
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
146,
149
]
} |
heterologous nucleic acids ( native dna , denatured dna , and trna ) exerted only a marginal effect on transfection with a viral replicative-form dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
36,
39
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
123,
128
]
} |
this report deals with a new hplc/fab/ms system , which was successfully applied to the structural characterization of the molecular species of neutral glycosphingolipids , and the system is a quite promising for development into a quantitative method for glycosphingolipids with high sensitivity and specificity . | NA | {
"id": "C0600570",
"name": "neutral glycosphingolipids",
"pos": [
144,
170
]
} | {
"id": "C0017978",
"name": "glycosphingolipids",
"pos": [
256,
274
]
} |
hr2a has the amino-terminal sequence of less than glu-gln-arg- and consists of a total of 202 residues with a calculated molecular weight of 23,015 . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
50,
53
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
54,
57
]
} |
furthermore , a comparison of the structures of various a-dna octamers reveals that the a-form can be divided into two subclasses such that the hexagonal structures have helical and base pair parameters that fall closer to fiber a-dna values , while in the tetragonal structures these parameters deviate more from fiber a-dna . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
14,
15
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
322,
325
]
} |
fluorescence titration of crystallins with tbcl3 revealed that this ion binds to delta- and beta-crystallins in solution . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
26,
37
]
} | {
"id": "C0005203",
"name": "beta-crystallins",
"pos": [
92,
108
]
} |
no other crystallins appear to have this motif . beta-crystallin also binds four ca2+ ions/aggregate unit of mass 160 kda , with an affinity of 2.6 x 10 ( 3 ) m-1 , presumably in the midregion of the molecule that is rich in anionic and polar residues . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
9,
20
]
} | {
"id": "C0005203",
"name": "beta-crystallin",
"pos": [
49,
64
]
} |
no other crystallins appear to have this motif . beta-crystallin also binds four ca2+ ions/aggregate unit of mass 160 kda , with an affinity of 2.6 x 10 ( 3 ) m-1 , presumably in the midregion of the molecule that is rich in anionic and polar residues . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
86,
90
]
} | {
"id": "C0003075",
"name": "anionic",
"pos": [
225,
232
]
} |
this result is in accord with spectroscopic studies which indicate that the binding of d or l amino acids ( or analogues thereof ) allows for more facile displacement of the metal-bound water by anions ( bicknell , r. , schaffer , a. , bertini , i. , luchinat , c. , vallee , b. l. , and auld , d. s. ( 1988 ) biochemistry 27 , 1050-1057 ) . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
195,
201
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
317,
318
]
} |
the lack of strong cross-reactivity of polyclonal antibodies raised separately against both forms of the enzyme indicates that the two isozymes possess unique structural properties . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
105,
111
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
135,
143
]
} |
factor xii in fresh plasma ( single-chain factor xii ) bound approximately 190 times less to mab f1 than factor xii in dextran sulfate-activated plasma ( cleaved factor xii ) . | NA | {
"id": "C0015527",
"name": "factor xii",
"pos": [
0,
10
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
162,
172
]
} |
as mab f1 can also induce this conformational change , this antibody may provide a unique tool in studies of the activation of factor xii . | NA | {
"id": "C0003250",
"name": "mab",
"pos": [
3,
6
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
60,
68
]
} |
incubation with gtp or gtp gamma s , in hypotonic buffer , which causes transient leakiness , increased dark levels by ip3 by 50 % . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
16,
19
]
} | {
"id": "C0079469",
"name": "gtp",
"pos": [
23,
26
]
} |
the major glycosides of the non-amidated bile acids were more polar than reference bile acid glucosides and gave quasimolecular ions at m/z 592 , 594 , and 610 consistent with n-acetylglucosaminides of unsaturated dihydroxy and saturated di- and trihydroxy bile acids . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
10,
20
]
} | {
"id": "C0017765",
"name": "glucosides",
"pos": [
93,
103
]
} |
fast atom bombardment mass spectrometry analyses of the glycine-and taurine-conjugated bile acid glycosides only showed ions consistent with the presence of glucosides ( m/z 626 and 676 ) . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
97,
107
]
} | {
"id": "C0017765",
"name": "glucosides",
"pos": [
157,
167
]
} |
endo-exonuclease was shown to have a low bona fide endonuclease activity with completely relaxed covalently closed circular dna and made site-specific breaks in linear double strand dna at a low frequency while simultaneously generating a relatively high level of single strand breaks ( nicks ) in the dna . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
115,
127
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
302,
305
]
} |
the results are interpreted to show how it is possible for endo-exonuclease to generate single strand dna for switching into a homologous duplex either at a nick or while remaining bound at a double strand break in the dna . | NA | {
"id": "C0012935",
"name": "single",
"pos": [
88,
94
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
219,
222
]
} |
when the agonist and antagonist photoaffinity labeled peptides were denatured and subjected to partial peptide map analysis using a two-dimensional gel electrophoresis system similar peptide fragments were generated from each specifically labeled protein . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
54,
61
]
} | {
"id": "C0030935",
"name": "peptide fragments",
"pos": [
183,
200
]
} |
these data indicate that all of the metallocarboxypeptidases are related , but the nondigestive carboxypeptidases with more specialized functions , present in cell membranes , blood plasma , or secretory granules ( i.e. , carboxypeptidase m , carboxypeptidase n and carboxypeptidase h ) , are more closely related to each other ( 41-49 % identity ) than they are to carboxypeptidase a or b ( 15-20 % identity ) . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
43,
60
]
} | {
"id": "C0003766",
"name": "carboxypeptidase n",
"pos": [
243,
261
]
} |
these data indicate that all of the metallocarboxypeptidases are related , but the nondigestive carboxypeptidases with more specialized functions , present in cell membranes , blood plasma , or secretory granules ( i.e. , carboxypeptidase m , carboxypeptidase n and carboxypeptidase h ) , are more closely related to each other ( 41-49 % identity ) than they are to carboxypeptidase a or b ( 15-20 % identity ) . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
43,
60
]
} | {
"id": "C0054757",
"name": "carboxypeptidase h",
"pos": [
266,
284
]
} |
these data indicate that all of the metallocarboxypeptidases are related , but the nondigestive carboxypeptidases with more specialized functions , present in cell membranes , blood plasma , or secretory granules ( i.e. , carboxypeptidase m , carboxypeptidase n and carboxypeptidase h ) , are more closely related to each other ( 41-49 % identity ) than they are to carboxypeptidase a or b ( 15-20 % identity ) . | NA | {
"id": "C0007075",
"name": "carboxypeptidases",
"pos": [
43,
60
]
} | {
"id": "C0054755",
"name": "carboxypeptidase a",
"pos": [
366,
384
]
} |
substrate specificity experiments of the purified enzyme revealed that ( i ) the minimal length of a peptide chain required for n alpha-acetylation is 10 residues , ( ii ) the amino acids , ala , ser , met , and gly , which are predominantly found in the n termini of n alpha-acetylated proteins , are not the sole determinant of n alpha-acetylation for 10 and more residue peptides , and ( iii ) n alpha-acetyltransferase recognizes a minute difference in the side chain structure at the n termini of acth1-18-nh2 and [ gly1 ] acth1-18-nh2 , a productive and a nonproductive substrate , respectively . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
176,
187
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
521,
524
]
} |
hen oviduct n alpha-acetyltransferase was clarified to have a nucleic acid as an existing constituent by the following three results : ( i ) an ultraviolet absorption spectrum of the purified n alpha-acetyltransferase free of s-acetyl coenzyme a ( ac-coa ) had an absorption maximum at 260 nm . | NA | {
"id": "C0001068",
"name": "acetyltransferase",
"pos": [
20,
37
]
} | {
"id": "C0001019",
"name": "acetyltransferase",
"pos": [
200,
217
]
} |
the contents of rna ( 35.0 % ) and protein ( 65.0 % ) in n alpha-acetyltransferase determined on weight basis corresponded reasonably well to the contents of rna ( 34.4 % ) and protein ( 65.6 % ) calculated based on the assumption that n alpha-acetyltransferase consisted of one molecule of 7 s rna ( mr 83,000 ) and two identical mr 79,000 protein subunits . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
35,
42
]
} | {
"id": "C0599220",
"name": "protein subunits",
"pos": [
341,
357
]
} |
vibrio cholera toxin and the heat-labile enterotoxin of escherichia coli have been shown to differ somewhat in their ligand specificity and in the antigenicity of their binding sites . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
15,
20
]
} | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
41,
52
]
} |
most of the carbohydrate detected by these lectins was located between 22 and 90 kda from the amino terminus of the protein . | NA | {
"id": "C0023206",
"name": "lectins",
"pos": [
43,
50
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
116,
123
]
} |
none of the phosphoproteins , however , was precipitated by either of two antisera containing antibodies differing in specificities for epitopes within gi alpha , despite precipitation of a substantial fraction of the subunit itself . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
74,
82
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
94,
104
]
} |
in contrast , other antisera , containing antibodies specific for the recently described gz alpha or both gz alpha and gi alpha , precipitated a 40-kda phosphoprotein . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
20,
28
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
42,
52
]
} |
there is a good correlation between the aggregation induced by various dna-binding proteins ( yssbs , dbps and histone proteins ) and the stimulation of stp alpha-mediated dna strand transfer . | NA | {
"id": "C0012940",
"name": "dna-binding proteins",
"pos": [
71,
91
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
119,
127
]
} |
a highly selective and sensitive high-performance liquid chromatographic method for the determination of catecholamines ( norepinephrine , epinephrine and dopamine ) and related compounds ( l-dopa , normetanephrine , metanephrine , 3-methoxytyramine , 3,4-dihydroxymandelic acid , 3,4-dihydroxyphenylacetic acid , homovanillic acid , vanillylmandelic acid , 3,4-dihydroxyphenylethylene glycol , 4-hydroxy-3-methoxyphenylethylene glycol and 4-hydroxy-3-methoxyphenylethanol ) with a post-column technique involving coulometric oxidation followed by fluorescence derivatization is described . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
122,
136
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
139,
150
]
} |
a highly selective and sensitive high-performance liquid chromatographic method for the determination of catecholamines ( norepinephrine , epinephrine and dopamine ) and related compounds ( l-dopa , normetanephrine , metanephrine , 3-methoxytyramine , 3,4-dihydroxymandelic acid , 3,4-dihydroxyphenylacetic acid , homovanillic acid , vanillylmandelic acid , 3,4-dihydroxyphenylethylene glycol , 4-hydroxy-3-methoxyphenylethylene glycol and 4-hydroxy-3-methoxyphenylethanol ) with a post-column technique involving coulometric oxidation followed by fluorescence derivatization is described . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
122,
136
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
199,
214
]
} |
a highly selective and sensitive high-performance liquid chromatographic method for the determination of catecholamines ( norepinephrine , epinephrine and dopamine ) and related compounds ( l-dopa , normetanephrine , metanephrine , 3-methoxytyramine , 3,4-dihydroxymandelic acid , 3,4-dihydroxyphenylacetic acid , homovanillic acid , vanillylmandelic acid , 3,4-dihydroxyphenylethylene glycol , 4-hydroxy-3-methoxyphenylethylene glycol and 4-hydroxy-3-methoxyphenylethanol ) with a post-column technique involving coulometric oxidation followed by fluorescence derivatization is described . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
125,
136
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
217,
229
]
} |
determination of the bisphosphonate pamidronate disodium in urine by pre-column derivatization with fluorescamine , high-performance liquid chromatography and fluorescence detection . | NA | {
"id": "C0043603",
"name": "determination",
"pos": [
0,
13
]
} | {
"id": "C2267018",
"name": "bisphosphonate",
"pos": [
21,
35
]
} |
two of 9 patients with miscellaneous adrenal disorders ( cushing 's disease , pigmented adrenal micronodular dysplasia , and adrenal nodules ) had acth-blocking activity . | NA | {
"id": "C0001621",
"name": "adrenal disorders",
"pos": [
37,
54
]
} | {
"id": "C0001622",
"name": "cushing 's disease",
"pos": [
57,
75
]
} |
[ 3h ] thymidine uptake was measured in chondrocyte clusters , and specific pg and coll ii rias were performed every 4 days on the culture medium and cell aggregates ; | NA | {
"id": "C0225369",
"name": "chondrocyte",
"pos": [
40,
51
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
150,
154
]
} |
in 8 nonsecreting adenomas , the mean trh concentration was 109 +/- 28 fmol/mg , about half of that in the prolactinomas . | NA | {
"id": "C0001430",
"name": "adenomas",
"pos": [
18,
26
]
} | {
"id": "C0033375",
"name": "prolactinomas",
"pos": [
107,
120
]
} |
when placental cells were preloaded with 40 microci/ml [ 3h ] myoinositol for 2 h at 37 c , aii stimulation resulted in a dose-dependent increase in inositol phosphate ( insp ) production [ ec50 = 1.4 +/- 0.4 ( +/- se ) nmol/l ] , as measured by ion exchange chromatography . | NA | {
"id": "C0021547",
"name": "myoinositol",
"pos": [
62,
73
]
} | {
"id": "C0021554",
"name": "inositol phosphate",
"pos": [
149,
167
]
} |
the mean integrated areas under the gh response-time curve after ghrh treatment were 3963 +/- 2086 min/micrograms.l following nacl infusion and 413 +/- 64 min/micrograms.l following met-hgh infusion in pa subjects ; | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
36,
38
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
186,
189
]
} |
oarswomen in groups a and b lost body weight and became leaner during the phase of high intensity training ( phase ii ) . | NA | {
"id": "C0005910",
"name": "body",
"pos": [
33,
37
]
} | {
"id": "C0039870",
"name": "leaner",
"pos": [
56,
62
]
} |
the sodium-retaining tendency of nonmodulators may reflect , at least in part , reduced intrarenal dopamine production in the sodium-replete state , but the adrenal defect in aldosterone release in nonmodulators is not mediated by excess dopaminergic inhibition of aldosterone secretion . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
99,
107
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
238,
250
]
} |
ventricular tachycardia in the nhd group showed a faster heart rate and narrower qrs duration than in the hd group . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
0,
23
]
} | {
"id": "C0039231",
"name": "faster heart",
"pos": [
50,
62
]
} |
the monoclonal antibody that works against human lung squamous cell carcinoma ( km 32 ) and antibody that works against human lung adenocarcinoma ( km 93 ) were isolated and purified . | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
4,
23
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
92,
100
]
} |
shiga toxin and the closely related shiga-like toxins produced by escherichia coli represent a group of very similar cytotoxins that may play an important role in diarrheal disease and hemolytic uremic syndrome . | NA | {
"id": "C0074447",
"name": "shiga toxin",
"pos": [
0,
11
]
} | {
"id": "C0148323",
"name": "shiga-like toxins",
"pos": [
36,
53
]
} |
a total of 55 patients had s. typhi cultured from their blood , 20 had s. typhi cultured from their stool , 24 were blood or stool culture positive for s. paratyphi a , 41 were culture negative but clinically diagnosed as having enteric fever , 41 had gastrointestinal or urinary tract infections , 41 were clinically diagnosed as having malaria , 20 were smear-positive patients with malaria , 58 had respiratory infections , and the remaining 39 individuals were placed in a miscellaneous group who did not have salmonella infection . | NA | {
"id": "C0041466",
"name": "enteric fever",
"pos": [
229,
242
]
} | {
"id": "C0036117",
"name": "salmonella infection",
"pos": [
514,
534
]
} |
furthermore , children with sbs had a higher frequency of repeated infection ( 3.1 catheter-associated infections compared with 1.3 catheter-associated infections in children with other disorders during the same period ) . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
67,
76
]
} | {
"id": "C0860239",
"name": "catheter-associated infections",
"pos": [
132,
162
]
} |
the fatty acids , alcohols , and mycolic acids of 26 strains of mycobacterium xenopi were studied by capillary gas chromatography and thin-layer chromatography . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
4,
15
]
} | {
"id": "C0026931",
"name": "mycolic acids",
"pos": [
33,
46
]
} |
these antibodies were used in a study to assess the feasibility of using monoclonal antibodies in place of conventional sera for radioimmunoassay . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
73,
94
]
} |
a new generation of dihydropyridine calcium antagonists which are related structurally to nifedipine is undergoing clinical investigation . | NA | {
"id": "C2945601",
"name": "dihydropyridine calcium antagonists",
"pos": [
20,
55
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
90,
100
]
} |
peak and trough concentrations after 8 weeks oral therapy with felodipine , a vasodilating calcium antagonist of the dihydropyridine group , were predicted from intravenous pharmacokinetic data before therapy in 11 patients , randomly allocated to felodipine treatment 10 mg b.i.d. , during a placebo controlled study in patients with congestive heart failure . | NA | {
"id": "C0015772",
"name": "felodipine",
"pos": [
63,
73
]
} | {
"id": "C2945601",
"name": "calcium antagonist",
"pos": [
91,
109
]
} |
the rostral medial accessory olive ( mao ) of the cat was studied by using an ultrastructural technique combining wheat germ agglutinin-coupled horseradish peroxidase ( wga-hrp ) anterograde tracing and postembedding gaba immunocytochemistry . | NA | {
"id": "C0019941",
"name": "horseradish",
"pos": [
144,
155
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
169,
176
]
} |
optic nerve fibers and retinal ganglion cells were retrogradely labeled by iontophoretic injections of wheat germ agglutinin conjugated to horseradish peroxidase ( wga-hrp ) into electrophysiologically defined positions of the lateral geniculate nucleus ( lgn ) . | NA | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
139,
161
]
} | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
164,
171
]
} |
although it is well known that magnocellular cholinergic basal forebrain neurons are trophically responsive to nerve growth factor ( ngf ) and contain ngf receptors ( ngfr ) , the exact distribution of forebrain ngfr-immunoreactive neurons and the degree to which cholinergic neurons are colocalized with them have remained in question . | NA | {
"id": "C0132173",
"name": "ngf",
"pos": [
133,
136
]
} | {
"id": "C0254837",
"name": "ngfr",
"pos": [
212,
216
]
} |
this result suggests that the monoclonal antibody technique might be useful for identifying new neuropeptides since the antibodies can be used for localization of the neuropeptidelike substances and , potentially , for immunoaffinity chromatography . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
30,
40
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
120,
130
]
} |
anatomical connections of the caudal portion of the fastigial nucleus ( fn ) with the inferior olive ( io ) were studied in macaque monkeys with wheat-germ-agglutinin-conjugated horseradish peroxidase ( wga/hrp ) and hrp . | NA | {
"id": "C0078473",
"name": "wga/hrp",
"pos": [
203,
210
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
217,
220
]
} |
( 3 ) there is an expression of class ii molecules on the keratinocytes and cancer cells of basal cell carcinoma , squamous cell carcinoma , bowen 's disease , seborrheic keratosis , and verrucous epidermal nevus ; | NA | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
115,
138
]
} | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
141,
157
]
} |
and ( 4 ) there is a netlike staining of the keratinocyte surface with okm5 in the epidermal lesion of seborrheic keratosis , verrucous epidermal nevus , and bowen 's disease , as well as in the epidermis adjacent to the basal cell carcinoma and squamous cell carcinoma nests . | NA | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
158,
174
]
} | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
246,
269
]
} |
in a group of 211 schoolchildren in queensland less than 12 years of age , the mean total melanocytic nevus ( mole ) count was 28 ( median 19 ) , and the mean count for raised nevi was 11 ( median 8 ) . | NA | {
"id": "C0027962",
"name": "melanocytic nevus",
"pos": [
90,
107
]
} | {
"id": "C0027960",
"name": "nevi",
"pos": [
176,
180
]
} |
three patients are described with clinical features of connective tissue diseases , namely , dermatomyositis , progressive systemic scleroderma , and systemic lupus erythematosus . | NA | {
"id": "C0009782",
"name": "of connective tissue",
"pos": [
52,
72
]
} | {
"id": "C0011633",
"name": "dermatomyositis",
"pos": [
93,
108
]
} |
because the donor heart is believed to be surgically denervated , the peak heart rate response to exercise is dependent primarily on 1 ) an increase in the circulating levels of the catecholamines norepinephrine and epinephrine at peak exercise , and 2 ) the end-organ responsiveness of the sinoatrial ( sa ) node to beta-adrenergic stimulation . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
197,
211
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
216,
227
]
} |
transient entrainment was used to test the hypotheses that 1 ) procainamide prolongs the cycle length of ventricular tachycardia in patients with coronary artery disease because it has a preferential effect on the reentrant tachycardia circuit , and 2 ) regions of slow conduction in the reentrant circuit are more susceptible to the effect of procainamide than are other areas of the ventricles . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
105,
128
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
224,
235
]
} |
allergenic and antigenic relationship between three species of storage mite and the house dust mite , dermatophagoides pteronyssinus . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
0,
10
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
15,
24
]
} |
in most cases , treatment with 1 thyroxine did not improve urticaria or angioedema , but a few patients demonstrated a dramatic response . | NA | {
"id": "C0042109",
"name": "urticaria",
"pos": [
59,
68
]
} | {
"id": "C0002994",
"name": "angioedema",
"pos": [
72,
82
]
} |
sixty-four black patients with inflammatory bowel disease ( ibd ) were seen from 1960 to 1987 at the medical college of georgia , representing 22 % of all patients with ibd : 38 of them had crohn 's disease ( cd ) and 26 had ulcerative colitis ( uc ) . | NA | {
"id": "C0021390",
"name": "ibd",
"pos": [
60,
63
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
190,
206
]
} |
isoelectric focusing studies have revealed that this enzyme is composed of several isozymes , one of which , an acidic form of gst called gst-pi , has been extracted from human placenta . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
53,
59
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
83,
91
]
} |
isoelectric focusing studies have revealed that this enzyme is composed of several isozymes , one of which , an acidic form of gst called gst-pi , has been extracted from human placenta . | NA | {
"id": "C0017837",
"name": "gst",
"pos": [
127,
130
]
} | {
"id": "C0537086",
"name": "gst-pi",
"pos": [
138,
144
]
} |
utilizing this system in conjunction with appropriate neutralizing monoclonal antibodies , we have demonstrated that interleukin-2 , interleukin-3/colony stimulating factor and tumor necrosis factor-alpha can be readily detected from in vivo aal . | NA | {
"id": "C0021757",
"name": "interleukin-3",
"pos": [
133,
146
]
} | {
"id": "C0009392",
"name": "colony",
"pos": [
147,
153
]
} |
studies are now underway to investigate the effect of fish-oil preparations or more-purified omega-3 fatty acids on arterial injury , thrombosis or atherosclerosis , as well as to study their effects in certain inflammatory or cutaneous disorders , such as psoriasis . | NA | {
"id": "C0016157",
"name": "fish-oil",
"pos": [
54,
62
]
} | {
"id": "C0015689",
"name": "omega-3 fatty",
"pos": [
93,
106
]
} |
our former finding that deposits of membrane attack complex of complement ( mac ) are found predominantly in skin lesions of patients with ic vasculitis and not in perilesional skin , has raised the question whether the complement system itself ( by way of the mac ) contributes to tissue damage . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
63,
73
]
} | {
"id": "C0009545",
"name": "mac",
"pos": [
261,
264
]
} |
the association of the endothelial cell swelling with deposits of mac suggests that the complement system can have a direct damaging effect on ec in ic vasculitis by the assembly of mac on the endothelial cell membrane . | NA | {
"id": "C0009545",
"name": "mac",
"pos": [
66,
69
]
} | {
"id": "C0009498",
"name": "mac",
"pos": [
182,
185
]
} |
charge-charge interactions enhance deposition of immune complexes in several organs , involving fixed negative charges in tissues and positive charges on antigens or antibodies in immune complexes . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
166,
176
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
180,
196
]
} |
the molecular weight of the 1c5-defined antigen was 26,000 daltons , and the epitope of the 1c5-defined antigen was carbohydrate moiety . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
77,
84
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
104,
111
]
} |
however the response to hcg stimulation of the 3 beta-hsd positive cells decreased significantly on day 20 , the 3 beta-hsd positive cells maintained the same responsiveness to dbcamp stimulation on progesterone secretion throughout pregnancy . | NA | {
"id": "C0020392",
"name": "hsd",
"pos": [
54,
57
]
} | {
"id": "C0000413",
"name": "3 beta-hsd",
"pos": [
113,
123
]
} |
a model of the dna and electron and ion track structure computer codes are used to model damage in the dna by direct action . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
103,
106
]
} |
the single a-t keratinocyte cell strain showed the same radiosensitivity as a-t fibroblast cell strains . | NA | {
"id": "C0022567",
"name": "cell strain",
"pos": [
28,
39
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
47,
50
]
} |
the single a-t keratinocyte cell strain showed the same radiosensitivity as a-t fibroblast cell strains . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
80,
90
]
} |
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