text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
our findings are not consistent with a direct effect of galanin on the k+ channels , but rather indicate that the effect of the neuropeptide is mediated by some intracellular coupling factor ( s ) . | NA | {
"id": "C0060993",
"name": "galanin",
"pos": [
56,
63
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
128,
140
]
} |
however , significant savings in dietary pr and reduced leg weakness may be economically beneficial when pr is restricted to 70 % of the 1984 nrc recommendations during early growth . | NA | {
"id": "C0012177",
"name": "dietary pr",
"pos": [
33,
43
]
} | {
"id": "C0033684",
"name": "pr",
"pos": [
105,
107
]
} |
the amount of dietary pr consumed per carcass pr gain decreased at all stages of growth as the level of pr decreased . | NA | {
"id": "C0012177",
"name": "dietary pr",
"pos": [
14,
24
]
} | {
"id": "C0033684",
"name": "pr",
"pos": [
104,
106
]
} |
selective inactivation of dopamine d1 and d2 receptors in 6-hydroxydopamine-lesioned rats : evidence that the effect of d1 and d2 agonists can be expressed in the absence of the heterologous da receptor . | NA | {
"id": "C0058698",
"name": "d2 receptors",
"pos": [
42,
54
]
} | {
"id": "C0034798",
"name": "da receptor",
"pos": [
191,
202
]
} |
the effects of disulfiram on the metabolism in vitro and elimination in vivo of hexobarbital were also measured . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
33,
43
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
57,
68
]
} |
the results suggest that : 1 ) the relative oral bioavailability of sodium pentobarbital is not influenced by dosing volume within the range tested , 2 ) the various dosing volumes of sp tested moved through the gastrointestinal tract at an equal rate , and 3 ) orally administered sp significantly decreases the propagation velocity and periodicity of the mmc in the small intestine . | NA | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
75,
88
]
} | {
"id": "C0700349",
"name": "sp",
"pos": [
282,
284
]
} |
the collagen biosynthesis was quantified by in vivo labeling with [ 3h ] proline and quantification of [ 3h ] hydroxyproline in pancreatic protein hydrolysates . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
73,
80
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
110,
124
]
} |
the latter could have some interest from the etiological point of view of certain pancreatic diseases , such as cystic fibrosis and pancreatitis . | NA | {
"id": "C0030286",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
132,
144
]
} |
variant alpha s1-cna differs from variant alpha s1-cnb by two substitutions , 16 leu ( a ) -- -- pro ( b ) and 77 gln ( a ) -- -- glu ( b ) , the latter inducing the appearance of a phosphate group on 75 ser . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
114,
117
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
130,
133
]
} |
the effect of a new dihydropyridine slow-channel calcium blocking agent , nisoldipine , on hemodynamics and myocardial blood flow in normal and collateral-dependent areas distal to a chronic coronary artery occlusion were studied in chronically instrumented , conscious dogs . | NA | {
"id": "C2945601",
"name": "dihydropyridine",
"pos": [
20,
35
]
} | {
"id": "C0028116",
"name": "nisoldipine",
"pos": [
74,
85
]
} |
some authors consider that the concept of epitope necessarily involves the two properties of antigenic reactivity ( ability to bind to a paratope ) and immunogenicity ( ability to induce an immune response ) . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
42,
49
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
93,
102
]
} |
the delineation of epitopes can be achieved by antigenic cross-reactivity studies or by x-ray crystallography . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
19,
27
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
47,
56
]
} |
both approaches require specific criteria for deciding which residues of the antigen are in contact with the paratope and are functionally part of the epitope . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
77,
84
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
151,
158
]
} |
neutralization epitopes are a special subclass of the epitopes of infectious agents and toxins that are specifically recognized by antibody molecules able to neutralize the biological activity of the antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
15,
23
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
200,
207
]
} |
x-ray diffraction analysis of crystals of a monoclonal fab fragment nc41 bound to a viral antigen , influenza virus neuraminidase , shows an epitope involving five surface loops of the antigen . | NA | {
"id": "C0003342",
"name": "viral antigen",
"pos": [
84,
97
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
185,
192
]
} |
x-ray diffraction analysis of crystals of a monoclonal fab fragment nc41 bound to a viral antigen , influenza virus neuraminidase , shows an epitope involving five surface loops of the antigen . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
141,
148
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
185,
192
]
} |
the complex dielectric constant of arginine and protamine from herring sperm ( clupeine ) and their complexes with herring sperm dna was measured at 10 ghz in the temperature range -20 to +45 degrees c by a microwave cavity perturbation method . | NA | {
"id": "C0033603",
"name": "protamine",
"pos": [
48,
57
]
} | {
"id": "C0009083",
"name": "clupeine",
"pos": [
79,
87
]
} |
overweight cafeteria fed animals lost weight in response to the gastric implant , whereas control chow fed animals did not . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
0,
10
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
38,
44
]
} |
these studies demonstrate that the gastric implant has more effect on weight in overweight animals on a palatable mixed diet , perhaps related to both mechanical and neural factors . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
70,
76
]
} | {
"id": "C0497406",
"name": "overweight",
"pos": [
80,
90
]
} |
experiments , involving para-chloro-d , l-phenylalanine-induced pup-killing ( filicide ) , were conducted to determine the effect of preexposure to the goal entity on the initial development and long-term expression of pcpa-induced filicide . | NA | {
"id": "C0031453",
"name": "l-phenylalanine",
"pos": [
40,
55
]
} | {
"id": "C0030135",
"name": "pcpa",
"pos": [
219,
223
]
} |
the present experiment used a saccharin aversion paradigm to evaluate the potential aversive action of t-2 toxin , a trichothecene mycotoxin that induces emesis and weight loss . | NA | {
"id": "C0040549",
"name": "toxin",
"pos": [
107,
112
]
} | {
"id": "C0026955",
"name": "mycotoxin",
"pos": [
131,
140
]
} |
much less is known about risk behavior patterns among gay men in smaller cities , where aids cases are less common and the prevalence of human immunodeficiency virus infection is relatively lower . | NA | {
"id": "C0001175",
"name": "aids",
"pos": [
88,
92
]
} | {
"id": "C0019693",
"name": "human immunodeficiency virus infection",
"pos": [
137,
175
]
} |
this was accompanied by a significant and percentage-wise similar increase in plasma epinephrine and norepinephrine . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
85,
96
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
101,
115
]
} |
eighty six obese children and adolescents ( 44 males ) were screened for urinary 5 hiaa and mhpg , noradrenaline ( na ) , and adrenaline ( a ) and the results compared with age- and sex-matched controls . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
126,
136
]
} |
urinary excretion of monoamine metabolites ( noradrenaline-na , adrenaline-a , 3-methoxy-4-hydroxyphenyl glycol-mhpg , homovanillic acid-hva , 5-hydroxyindole acetic acid-5 hiaa ) was studied in four groups of children as follows : group i consisting of obese children subjected to caloric restriction and to a short term course of thyroid extract in `` '' low '' '' dosage ( 1-2 mg/kg bwt ) , group ii consisting of obese children subjected to diet alone , group iii consisting of children myxedema and subjected to a short term course of thyroid extract given in the `` '' high '' '' dosage ( 3-5 mg/kg bwt ) and group iv consisting of gh deficient short children having ( many of them ) thyrotropin deficiency and subjected to a short term course of thyroid extract in `` '' very high '' '' dosage ( 5-10 mg/bwt ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
45,
58
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
the antibody showed a higher affinity to the g + c-rich dna fragment ( 71 % g + c ) than to the a + t-rich dna fragment ( 46 % g + c ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
4,
5
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
107,
110
]
} |
special attention was paid to vascular complications ( infarction or hemorrhage ) , infections ( meningitis or brain abscess ) and mental changes when they were the only signs of cns origin ( lowered level of consciousness , confusion or delirium ) . | NA | {
"id": "C0009676",
"name": "confusion",
"pos": [
225,
234
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
238,
246
]
} |
in controlled comparative clinical trials , ciprofloxacin has been found to have similar clinical efficacy as amoxycillin , ampicillin , cefalexin , doxycycline , co-trimoxazole , imipenem-cilastatin and ceftazidime for the treatment of a range of lower respiratory tract infections . | NA | {
"id": "C0002645",
"name": "amoxycillin",
"pos": [
110,
121
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
124,
134
]
} |
during the entire period the use of tetracyclines , and especially doxycycline , was extensive -- almost 10 million ddds in 1987 . | NA | {
"id": "C0039651",
"name": "tetracyclines",
"pos": [
36,
49
]
} | {
"id": "C0013090",
"name": "doxycycline",
"pos": [
67,
78
]
} |
a literature review reveals another 31 patients with this characteristic form of colitis associated with ampicillin or amoxicillin therapy . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
105,
115
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
119,
130
]
} |
the usual parameters such as protein content , ldh ratio , albumin quotient and albumin gradient , fibronectin , cholesterol and cell count did not reliably differentiate the etiology in each particular case , although the mean values of the various groups differed significantly . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
29,
36
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
80,
87
]
} |
image analysis has been performed on electron micrographs of filaments of reca on double-stranded dna and on single-stranded dna to visualize a difference that is consistent with one strand of the double-stranded dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
109,
128
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
197,
216
]
} |
a complementary dna ( cdna ) for the rat luteal lutropin-choriogonadotropin receptor ( lh-cg-r ) was isolated with the use of a dna probe generated in a polymerase chain reaction with oligonucleotide primers based on peptide sequences of purified receptor protein . | NA | {
"id": "C0006556",
"name": "complementary dna",
"pos": [
2,
19
]
} | {
"id": "C0012893",
"name": "dna probe",
"pos": [
128,
137
]
} |
the hydrophobicities of interior residues of both membrane and water-soluble proteins are comparable , whereas the bilayer-exposed residues of membrane proteins are more hydrophobic than the interior residues , and the aqueous-exposed residues of water-soluble proteins are more hydrophilic than the interior residues . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
50,
58
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
261,
269
]
} |
in a study investigating factors affecting labour pain , 10 out of 97 subjects reported that they had never experienced any pain outwit childbirth . | NA | {
"id": "C0474368",
"name": "labour pain",
"pos": [
43,
54
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
124,
128
]
} |
it is concluded that infusions of small volume of 7.5 per cent sodium chloride or 7.5 per cent sodium chloride in 6.0 per cent dextran 70 solutions in rats in a state of uncontrolled hemorrhagic shock led to increased bleeding , decrease in mean arterial pressure and increased mortality . | NA | {
"id": "C0036982",
"name": "hemorrhagic shock",
"pos": [
183,
200
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
218,
226
]
} |
the caries registrations distinguished between enamel caries and root caries , subdivided into manifest and initial caries . | NA | {
"id": "C0011334",
"name": "caries",
"pos": [
4,
10
]
} | {
"id": "C0162644",
"name": "root caries",
"pos": [
65,
76
]
} |
seventy-seven finnish and 85 swedish 14-year-olds were examined for caries , gingivitis , calculus and presence of gingival pockets . | NA | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
77,
87
]
} | {
"id": "C0017571",
"name": "gingival pockets",
"pos": [
115,
131
]
} |
this treatment produced a pronounced leukopenia , granulocytopenia and thrombocytopenia with a nadir between days 7-16 with recovery occurring on days 19-21 . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
37,
47
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
50,
66
]
} |
it was found that adenine nucleotide levels were almost doubled in the rop-preserved kidneys , principally due to higher adenosine triphosphate ( atp ) concentrations . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
18,
36
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
121,
143
]
} |
a comparative immunomorphologic study was carried out on cryostate sections of renal tissue of plaice ( pleuronectes platessa l. ) and rat , using specific antibodies against the proteins of intermediate filaments -- cytokeratins and vimentin . | NA | {
"id": "C0021769",
"name": "proteins",
"pos": [
179,
187
]
} | {
"id": "C0042666",
"name": "vimentin",
"pos": [
234,
242
]
} |
between 1977 and 1987 at trauma hospital in salzburg 142 patients with shaft fractures in the middle third of forearm have been treated by open reduction ( altogether 730 forearm fractures in the same period ) . | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
25,
31
]
} | {
"id": "C0016658",
"name": "fractures",
"pos": [
179,
188
]
} |
immediate hypersensitivity was evaluated by help of diagnostic allergens ( mould , yeast and bacterial ones ) , delayed hypersensitivity by help of staphylococcus lysate , cellular immunity ( tests de novo ) by help of phytohemagglutinin and as common recall antigens were used tuberculin , toxoplasmin , candidic and tetanic antigen . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
63,
72
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
326,
333
]
} |
the following dehydrogenases were investigated : succinate dehydrogenase ( sdh , ec 1.3.99.1 . ) , glycerol-3-phosphate dehydrogenase ( glycerol-3-phosphate : menadion oxidoreductase , gpox , ec 1.1.99.5 . ) | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
49,
72
]
} | {
"id": "C0283592",
"name": "sdh",
"pos": [
75,
78
]
} |
the life span and cumulation of heavy metals in the liver of 12 ewes of the improved wallachian breed were investigated in relation to feeding pollutants from a copper works . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
32,
44
]
} | {
"id": "C0009968",
"name": "copper",
"pos": [
161,
167
]
} |
the comparison involved sympathetic-adrenal function ( by urine excretion of epinephrine and norepinephrine ) , specific and nonspecific immune reactivity ( by the level of iga , igm , igg , circulating immune complexes , t and b lymphocytes ; rf titers , leukocyte migration inhibition test ) , platelet components of hemostasis ( number of platelets , adhesion induced by adp and epinephrine ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
93,
107
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
382,
393
]
} |
drinking mineral water was found to stimulate trophic processes in gastroduodenal mucosa , more pronounced for waters of complex chemical composition , e. g . | NA | {
"id": "C0599638",
"name": "drinking",
"pos": [
0,
8
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
111,
117
]
} |
the fibrinolytic system of the blood was studied in 46 patients with osteoarthrosis ( oa ) associated with reactive synovitis or without it , 44 patients with rheumatoid arthritis ( ra ) without visceral manifestations . | NA | {
"id": "C0022408",
"name": "osteoarthrosis",
"pos": [
69,
83
]
} | {
"id": "C0039103",
"name": "synovitis",
"pos": [
116,
125
]
} |
increase of the level of fibrin monomers ( fm ) in the blood are observed in oa with reactive synovitis . | NA | {
"id": "C0022408",
"name": "oa",
"pos": [
77,
79
]
} | {
"id": "C0039103",
"name": "synovitis",
"pos": [
94,
103
]
} |
the concentration of fm in the blood in ra and oa with reactive synovitis is an informative and dynamic sign of the activity of the inflammatory process and efficacy of treatment . | NA | {
"id": "C0022408",
"name": "oa",
"pos": [
47,
49
]
} | {
"id": "C0039103",
"name": "synovitis",
"pos": [
64,
73
]
} |
these results indicate that the presence of de-epoxy don in rat excreta , following the oral administration of don , is the result of metabolism by micro-organisms in the gut . | NA | {
"id": "C0221102",
"name": "excreta",
"pos": [
64,
71
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
134,
144
]
} |
following these ideas an immunosuppressive therapy to prevent the progression of myocarditis to dilative cardiomyopathy is discussed . | NA | {
"id": "C0027059",
"name": "myocarditis",
"pos": [
81,
92
]
} | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
105,
119
]
} |
in a chronic , placebo-controlled , double-blind cross-over study a potential therapeutic effect of coenzyme q10 ( ubiquinone ) was investigated in 25 patients suffering from dilative cardiomyopathy ( nyha functional class i , ii , iii ) . | NA | {
"id": "C0056077",
"name": "q10",
"pos": [
109,
112
]
} | {
"id": "C0041536",
"name": "ubiquinone",
"pos": [
115,
125
]
} |
group a patients had a significant lower ef ( 27 +/- 10 vs 36 +/- 9 % , p less than 0.03 ) , a lower myocardial norepinephrine ( 254 +/- 168 vs 579 +/- 416 pg/mg , p less than 0.007 ) , higher plasma norepinephrine ( 640 +/- 333 vs 372 +/- 254 pg/ml , p less than 0.008 ) and plasma epinephrine ( 391 +/- 340 vs 116 +/- 81 pg/ml , p less than 0.006 ) in comparison to patients , who were still alive and not transplanted ( group b ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
112,
126
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
283,
294
]
} |
survival was significantly lower in patients with an ef less than 30 % , a plasma norepinephrine concentration greater than 350 pg/ml , a plasma epinephrine concentration greater than 125 pg/ml , and a myocardial norepinephrine content less than 400 pg/mg . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
85,
96
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
213,
227
]
} |
in the tissues examined , the ab reaction of acidic glycoconjugates involved was effectively intensified by subsequent pta staining in nearly all of the ultrastructures known to contain such carbohydrates . | NA | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
52,
67
]
} | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
191,
204
]
} |
diabetic patients were found to have a more severe course of ihd after myocardial infarction , which was more often complicated with arrhythmias , cardiac failure , and unstable angina . | NA | {
"id": "C0018799",
"name": "of ihd",
"pos": [
58,
64
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
133,
144
]
} |
the incidence of painless ihd after myocardial infarction was found to be twice higher in diabetics . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
36,
57
]
} |
in the group of patients with refractory anemia with excess of blasts ( raeb ) and in those with chronic myelomonocytic leukemia , the percentage and absolute numbers of okt8 lymphocytes were significantly lower ( p less than 0.025 ) than in patients with refractory anemia or with primary acquired sideroblastic anemia , while those of okt3 and okt4 did not differ significantly . | NA | {
"id": "C0002894",
"name": "with refractory anemia",
"pos": [
25,
47
]
} | {
"id": "C0002893",
"name": "refractory anemia",
"pos": [
256,
273
]
} |
we had shown previously that increased residual glucose metabolism in reperfused myocardium can be assessed by f-18 2-deoxy-glucose ( fdg ) and positron emission tomography ( pet ) and will predict functional recovery in reperfused myocardium . | NA | {
"id": "C0011501",
"name": "deoxy-glucose",
"pos": [
118,
131
]
} | {
"id": "C0046056",
"name": "fdg",
"pos": [
134,
137
]
} |
in contrast , the phorbol ester , phorbol 12-myristate 13-acetate , produced a biphasic change in the level of choline acetyltransferase activity ; | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
18,
31
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
34,
41
]
} |
30 angioarchitectural analyses could be obtained and allowed to classify these vgms into 5 different types : 44 % parenchymatous avms , 20 % mural avfs , 30 % choroidal arteriovenous fistulas , 3 % dural avfs , 7 % vein of galen varices . | NA | {
"id": "C0003857",
"name": "avms",
"pos": [
129,
133
]
} | {
"id": "C0003855",
"name": "arteriovenous fistulas",
"pos": [
169,
191
]
} |
igg was found to decline progressively throughout gestation with a very highly significant decrease between the first and second trimester ( 0.01 greater than p greater than 0.005 ) and between the second and third trimesters ( p = 0.01 ) . | NA | {
"id": "C0032961",
"name": "gestation",
"pos": [
50,
59
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
122,
138
]
} |
igg was found to decline progressively throughout gestation with a very highly significant decrease between the first and second trimester ( 0.01 greater than p greater than 0.005 ) and between the second and third trimesters ( p = 0.01 ) . | NA | {
"id": "C0032961",
"name": "gestation",
"pos": [
50,
59
]
} | {
"id": "C0032981",
"name": "third trimesters",
"pos": [
209,
225
]
} |
hb concentration , haematocrit , and hb a2 did not differ in subjects with hb f levels lower than 2 % ( group i ) when compared with those whose hb f levels were higher than 8 % ( group ii ) . | NA | {
"id": "C0019046",
"name": "hb",
"pos": [
0,
2
]
} | {
"id": "C0015936",
"name": "hb f",
"pos": [
145,
149
]
} |
there was no statistical difference between both groups regarding age , sex , underlying heart disease , ejection fraction or entry arrhythmia . | NA | {
"id": "C0018799",
"name": "heart",
"pos": [
89,
94
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
132,
142
]
} |
in malabsorption or in the short bowel syndrome , a high caloric load or unabsorbed nutrients in the jejunum further inhibits pancreatic secretion , contributing to the loss of nutrients from the intestinal tract . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
3,
16
]
} | {
"id": "C0036992",
"name": "short bowel syndrome",
"pos": [
27,
47
]
} |
linoleic and linolenic acids were similar in the three adipose-tissue sites , an important finding for those concerned about the essential fatty acids , which are solely derived from the diet . | NA | {
"id": "C0023752",
"name": "linolenic acids",
"pos": [
13,
28
]
} | {
"id": "C0015686",
"name": "essential fatty acids",
"pos": [
129,
150
]
} |
the vitamin should be given with caution to drug-treated epileptic patients because seizure control may be affected . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
57,
66
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
84,
91
]
} |
these results suggested that carcinoid tumors in the gallbladder have a multidirectional differentiation represented by a morphological continuum ranging from carcinoid to adenocarcinoma . | NA | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
29,
38
]
} | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
172,
186
]
} |
in order to assess the actual degree of activation of coagulation and fibrinolytic systems in liver disease , plasma levels of thrombin-antithrombin iii complex ( tat ) and plasmin-alpha 2-antiplasmin complex ( pap ) were measured together with cross-linked fibrin derivatives ( xdp ) , tissue-type plasminogen activator ( t-pa ) , and plasminogen activator inhibitor ( pai-1 ) in 31 patients with liver disease ( five patients with acute hepatitis , seven with chronic hepatitis , nine with liver cirrhosis , and ten with hepatocellular carcinoma ) . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
94,
107
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
492,
507
]
} |
treatment with intraperitoneal antibiotics succeeded in 21 cases ( 91 % ) without cpd interruption or catheter removal , with tobramycin or gentamicin alone in 16 cases , and with combined aminoglycoside and penicillin or cephalosporin in six cases . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
140,
150
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
189,
203
]
} |
19 % of fentanyl and 31 % of sufentanil removed from inventory were not recorded as administered , returned , or wasted . | NA | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
8,
16
]
} | {
"id": "C0143993",
"name": "sufentanil",
"pos": [
29,
39
]
} |
beginning on december 1 , 1987 , pharmacists at this university-affiliated teaching hospital used the antimicrobial order sheet ( aos ) filled out by all prescribers of anti-infective agents to identify orders that were potential candidates for streamlining . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
102,
115
]
} | {
"id": "C0003204",
"name": "anti-infective",
"pos": [
169,
183
]
} |
new , previously unknown lesions ( including nine malignancies ) were discovered in 20 of 59 case subjects ( 34 % ) with gastrointestinal bleeding or hematuria , but in only two of 71 case subjects ( 3 % ) with other bleeding ( p less than 0.001 ) . | NA | {
"id": "C0018965",
"name": "hematuria",
"pos": [
150,
159
]
} | {
"id": "C0019080",
"name": "bleeding",
"pos": [
217,
225
]
} |
although it is well known that yersiniosis sometimes affects glomeruli , this is the first report to demonstrate acute interstitial nephritis in patients with y. pseudotuberculosis infection . | NA | {
"id": "C0043407",
"name": "yersiniosis",
"pos": [
31,
42
]
} | {
"id": "C0043410",
"name": "pseudotuberculosis",
"pos": [
162,
180
]
} |
two patients with angiolymphoid hyperplasia with eosinophilia isolated to the orbit had eyelid swelling , a superior orbital mass , and histories of intermittent obstructive airway disease . | NA | {
"id": "C0002989",
"name": "angiolymphoid hyperplasia",
"pos": [
18,
43
]
} | {
"id": "C0014457",
"name": "eosinophilia",
"pos": [
49,
61
]
} |
this study confirms and extends previous reports on the endogenous presence of epitopes of retroviral antigens in thymic epithelium . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
79,
87
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
102,
110
]
} |
immobilized phenylboronic acid was applied to the isolation of nucleosides , nucleotides , and glycoprotein hormones such as bovine follicotropin and human chorionic gonadotropin , while immobilized benzamidine was employed for the isolation of the serine proteases thrombin and trypsin , immobilized tri-l-alanine for the separation of pig pancreatic elastase and human leukocyte elastase , and immobilized concanavalin a for the isolation of horseradish peroxidase . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
249,
265
]
} | {
"id": "C0041236",
"name": "trypsin",
"pos": [
279,
286
]
} |
immobilized phenylboronic acid was applied to the isolation of nucleosides , nucleotides , and glycoprotein hormones such as bovine follicotropin and human chorionic gonadotropin , while immobilized benzamidine was employed for the isolation of the serine proteases thrombin and trypsin , immobilized tri-l-alanine for the separation of pig pancreatic elastase and human leukocyte elastase , and immobilized concanavalin a for the isolation of horseradish peroxidase . | NA | {
"id": "C0036734",
"name": "serine proteases",
"pos": [
249,
265
]
} | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
341,
360
]
} |
immobilized phenylboronic acid was applied to the isolation of nucleosides , nucleotides , and glycoprotein hormones such as bovine follicotropin and human chorionic gonadotropin , while immobilized benzamidine was employed for the isolation of the serine proteases thrombin and trypsin , immobilized tri-l-alanine for the separation of pig pancreatic elastase and human leukocyte elastase , and immobilized concanavalin a for the isolation of horseradish peroxidase . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
341,
360
]
} | {
"id": "C0064833",
"name": "human leukocyte elastase",
"pos": [
365,
389
]
} |
the resolution of substrates and products of seven amino acid decarboxylases , namely , arginine , aspartate , 2,6-diaminopimelate , histidine , glutamate , lysine , and ornithine decarboxylase , is complete within 15 to 35 min of isocratic elution . | NA | {
"id": "C0007054",
"name": "decarboxylases",
"pos": [
62,
76
]
} | {
"id": "C0029282",
"name": "ornithine decarboxylase",
"pos": [
170,
193
]
} |
reproducible results were obtained when 25 mm tris-192 mm glycine was used as the transfer buffer instead of 0.7 % acetic acid , 50 mm sodium acetate , ph 4 , or 0.14 m acetic acid -- 0.35 m beta-alanine , ph 4.3 . | NA | {
"id": "C0142785",
"name": "sodium acetate",
"pos": [
135,
149
]
} | {
"id": "C0000983",
"name": "acetic acid",
"pos": [
169,
180
]
} |
in conclusion , this technique offers many advantages over the methodologies currently employed involving anion-exchange chromatography and [ 3h ] inositol labeling : ( i ) 32p labeling is less expensive and more efficient than 3h labeling and can be used with all types of cells without permeabilization treatments and ( ii ) ion-pair hplc gives good resolution of inositol phosphates from nucleotides with shorter retention times , and long reequilibration periods are not required . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
106,
111
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
479,
480
]
} |
in conclusion , this technique offers many advantages over the methodologies currently employed involving anion-exchange chromatography and [ 3h ] inositol labeling : ( i ) 32p labeling is less expensive and more efficient than 3h labeling and can be used with all types of cells without permeabilization treatments and ( ii ) ion-pair hplc gives good resolution of inositol phosphates from nucleotides with shorter retention times , and long reequilibration periods are not required . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
106,
111
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
455,
458
]
} |
in conclusion , this technique offers many advantages over the methodologies currently employed involving anion-exchange chromatography and [ 3h ] inositol labeling : ( i ) 32p labeling is less expensive and more efficient than 3h labeling and can be used with all types of cells without permeabilization treatments and ( ii ) ion-pair hplc gives good resolution of inositol phosphates from nucleotides with shorter retention times , and long reequilibration periods are not required . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
147,
155
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
366,
385
]
} |
the examples are presented in three broad categories : protein separations , peptide separations , and the application of both to the analysis of recombinant protein products . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
55,
62
]
} | {
"id": "C0034861",
"name": "recombinant protein",
"pos": [
146,
165
]
} |
in the second section , protein separations are presented that show the resolution of glycoproteins having the same primary structure and the separation of immune complexes from free unreacted antibody and antigen . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
156,
172
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
193,
201
]
} |
quantitative recovery of hg from samples spiked with mercuric chloride , methylmercury ( ii ) chloride , and phenylmercury ( ii ) acetate was attainable in the presence of naturally occurring suspended matter and humic and fulvic acids as well as 3 % nacl . | NA | {
"id": "C0025417",
"name": "mercuric chloride",
"pos": [
53,
70
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
94,
102
]
} |
quantitative recovery of hg from samples spiked with mercuric chloride , methylmercury ( ii ) chloride , and phenylmercury ( ii ) acetate was attainable in the presence of naturally occurring suspended matter and humic and fulvic acids as well as 3 % nacl . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
62,
70
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
251,
255
]
} |
the thiol derivatives of dbd-f were separated by high-performance liquid chromatography and detected fluorimetrically , the detection limits being 0.92 , 0.16 , 0.13 , 0.16 and 0.32 pmol for cysteine , glutathione , homocysteine , n-acetylcysteine and alpha-mercaptopropionylglycine , respectively . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
191,
199
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
231,
247
]
} |
the sorbability of some ionic species and the sorption abilities of different types of mf were evaluated in terms of the sorption constant defined by ksor , ca = [ ( c+ , a- ) f ] / [ c+ ] [ a- ] , where c+ , a- and ( c+ , a- ) refer to the cation , anion and the ion pair , respectively , and f refers to the filter phase . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
241,
247
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
264,
267
]
} |
the sorbability of some ionic species and the sorption abilities of different types of mf were evaluated in terms of the sorption constant defined by ksor , ca = [ ( c+ , a- ) f ] / [ c+ ] [ a- ] , where c+ , a- and ( c+ , a- ) refer to the cation , anion and the ion pair , respectively , and f refers to the filter phase . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
250,
255
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
264,
267
]
} |
the sorbability of some ionic species and the sorption abilities of different types of mf were evaluated in terms of the sorption constant defined by ksor , ca = [ ( c+ , a- ) f ] / [ c+ ] [ a- ] , where c+ , a- and ( c+ , a- ) refer to the cation , anion and the ion pair , respectively , and f refers to the filter phase . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
250,
255
]
} | {
"id": "C0016327",
"name": "f",
"pos": [
310,
311
]
} |
patients receiving 0.1 mg or 0.2 mg morphine reported significantly less postoperative pain as assessed by an inverse numerical visual pain scale and required significantly fewer postoperative analgesic interventions than the control group . | NA | {
"id": "C0030201",
"name": "postoperative",
"pos": [
73,
86
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
135,
139
]
} |
to determine the onset time and duration of high doses of vecuronium , 40 asa physical status 1 and 2 patients were randomly assigned to receive either 100 , 200 , 300 , or 400 micrograms/kg of vecuronium bromide for muscle relaxation during elective general surgery . | NA | {
"id": "C0242531",
"name": "vecuronium",
"pos": [
58,
68
]
} | {
"id": "C0042435",
"name": "vecuronium bromide",
"pos": [
194,
212
]
} |
the crest syndrome ( calcinosis , raynaud 's phenomenon , esophageal dysmotility , sclerodactyly , telangiectasia ) is a variant but not a benign form of scleroderma . | NA | {
"id": "C0206138",
"name": "crest syndrome",
"pos": [
4,
18
]
} | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
21,
31
]
} |
thiamine deficiency is not uncommon in certain populations and clinical disease states such as wernicke 's encephalopathy or beriberi . | NA | {
"id": "C0039841",
"name": "thiamine deficiency",
"pos": [
0,
19
]
} | {
"id": "C0005122",
"name": "beriberi",
"pos": [
125,
133
]
} |
measurements and main results : we found a significant elevation in fasting cholesterol ( 6.23 +/- 0.28 mmol/l [ mean +/- se ] compared with 5.17 +/- 0.13 mmol/l [ 241 +/- 11 mg/dl compared with 200 +/- 5 mg/dl ] , p less than 0.01 ) , low density lipoprotein ( ldl ) cholesterol ( 4.11 +/- 0.23 mmol/l compared with 3.34 +/- 0.13 mmol/l [ 159 +/- 9 mg/dl compared with 129 +/- 5 mg/dl ] , p less than 0.05 ) , and triglycerides ( 1.85 +/- 0.26 mmol/l compared with 1.11 +/- 0.07 mmol/l [ 164 +/- 23 mg/dl compared with 98 +/- 6 mg/dl ] , p less than 0.001 ) in men with hyperprolactinemia compared with controls . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
76,
87
]
} | {
"id": "C0023824",
"name": "low density lipoprotein",
"pos": [
236,
259
]
} |
in the normoprolactinemic hypogonadal men , cholesterol ( 6.28 +/- 0.34 mmol/l [ 243 +/- 13 mg/dl ] , p less than 0.01 ) , ldl cholesterol ( 4.34 +/- 0.34 mmol/l [ 168 +/- 13 mg/dl ] , p less than 0.01 ) , and triglycerides ( 1.61 +/- 0.18 mmol/l [ 143 +/- 16 mg/dl ] , p less than 0.05 ) were also significantly higher than in the controls , and were the same as in the hyperprolactinemic men . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023824",
"name": "ldl cholesterol",
"pos": [
123,
138
]
} |
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