text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
epinephrine and norepinephrine concentrations were some 600 times and 90 times higher , respectively , than that of dopamine in adrenal medulla but were barely detectable in caudate nucleus . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
0,
11
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
16,
30
]
} |
csf concentrations of free and conjugated norepinephrine and epinephrine , 3-methoxy-4-hydroxyphenylglycol , and homovanillic acid were unchanged after the transplantation . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
42,
56
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} |
rather , the progressive rise in plasma ldl-cholesterol levels seen in western man is likely due to the consumption of a diet enriched in cholesterol and saturated triglyceride which increases the ldl-cholesterol production rate and suppresses receptor-dependent ldl transport . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
44,
55
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
197,
212
]
} |
in an attempt to determine the physiological role of these receptor systems , experiments were carried out in which the plasma acth and serum corticosterone concentrations were determined before and after stress in rats treated s.c. with selective antagonists of mu- ( naloxone , naltrexone ) , delta- ( ici 174864 ) and kappa- ( mr2266 ) opioid receptors . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
269,
277
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
280,
290
]
} |
neither naloxone ( 25-100 micrograms/100 g ) nor naltrexone ( 50 micrograms/100 g ) influenced the resting plasma acth or serum corticosterone concentrations . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
8,
16
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
49,
59
]
} |
the opioid receptor antagonists naloxone , naltrexone and nalmefene injected before and after single daily ecs were unable to block this effect of ecs on vo . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
32,
40
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
43,
53
]
} |
we have looked at the relationship between fasting levels of insulin and a small insulin-like growth factor ( igf ) -binding protein ( ibp-1 ) in a cross-sectional study of 116 normal subjects aged 5-48 years . | NA | {
"id": "C0074825",
"name": "insulin-like growth factor",
"pos": [
81,
107
]
} | {
"id": "C0123256",
"name": "ibp-1",
"pos": [
135,
140
]
} |
children 's responses to questions , as well as their external representations , suggested that children as young as second grade have substantial understanding of hierarchical relations . | NA | {
"id": "C0008059",
"name": "children 's",
"pos": [
0,
11
]
} | {
"id": "C0728836",
"name": "children",
"pos": [
96,
104
]
} |
furthermore , the frequency at which ha-specific t cells have been identified that focus on amino acids within the ha1 subunit of ha also featuring in antigenic drift , suggests that a failure of mhc class ii-restricted t cells to recognize specific epitopes within mutant ha molecules may contribute significantly to the capacity of variant influenza viruses to evade immune recognition . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
151,
160
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
250,
258
]
} |
lactoferrin ( lf ) , the major iron-binding component of milk , also a major constituent of the specific granules of neutrophils involved in antimicrobial activity and a glycoprotein thought to play a role in regulatory functions in the hematopoietic system as well as other physiologic activities , is shown to occur in three isoforms . | NA | {
"id": "C0022942",
"name": "lactoferrin",
"pos": [
0,
11
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
170,
182
]
} |
striking similarities between vaccinia virus hemagglutinin ( vvha ) and proteins belonging to the ig superfamily clearly indicate that vvha , a 315-amino acid glycoprotein expressed on the surface of the infected cells , is a novel viral protein that can be added to the expanding list of the ig superfamily . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
72,
80
]
} | {
"id": "C0042736",
"name": "viral",
"pos": [
232,
237
]
} |
subjects were asked to record daily in a special diary ( 1 ) the presence or absence of headache , ( 2 ) duration of headache , ( 3 ) severity of headache , and ( 4 ) use of pain medication for headache relief . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
174,
178
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
194,
202
]
} |
several clinical isolates of escherichia coli from national taiwan university hospital ( ntuh ) were shown to be ampicillin-resistant and found to contain the penicillinase-type of beta-lactamase . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
159,
172
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
181,
195
]
} |
these findings suggest that lithium carbonate can influence the tsh receptor in vitro and may be one of the action mechanisms of lithium on the thyroid gland . | NA | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
28,
45
]
} | {
"id": "C0023870",
"name": "lithium",
"pos": [
129,
136
]
} |
in the presence of 2.5 mm ca2+ bicuculline and baclofen were 57 and 46 % as effective as gaba to displace 3h-gaba from ibat binding sites . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
47,
55
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
109,
113
]
} |
exclusive localization in the neuropil of presumed dopamine release sites is similar to that previously found for the neuropeptide scp but differs from the widespread ramification of varicose neurites containing 5-ht , fmrfamide , and elh . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
118,
130
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
219,
228
]
} |
and prednisolone , 60 mg/m2 x 5 ( acvb ) , consolidation with high-dose methotrexate , ifosfamide , etoposide , asparaginase , and cytarabine , and a randomized late intensification with two courses of cytarabine , cyclophosphamide , teniposide , bleomycin , and prednisone ( aracvmb ) . | NA | {
"id": "C0020823",
"name": "ifosfamide",
"pos": [
87,
97
]
} | {
"id": "C0010583",
"name": "cyclophosphamide",
"pos": [
215,
231
]
} |
several outbreaks of skin infection are described in which the source and route of infection have been identified . | NA | {
"id": "C0037278",
"name": "of skin infection",
"pos": [
18,
35
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
83,
92
]
} |
application of a phorbol ester , 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) , that activates protein kinase c ( c-kinase ) , produces a long-lasting , low-level facilitation of evoked epsps . | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
17,
24
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
33,
70
]
} |
jaw opening now occurred in three stages : o1 was the fall from tooth contact to approximately the postural position , o2 was a pause , and o3 was defined as the final movement to maximum opening . | NA | {
"id": "C0030054",
"name": "o2",
"pos": [
119,
121
]
} | {
"id": "C0030106",
"name": "o3",
"pos": [
140,
142
]
} |
to determine the influence of methionine on selenomethionine ( semet ) metabolism , weanling male rats were fed for 8 wk a basal diet marginally deficient in sulfur amino acids , containing 2.0 micrograms selenium ( se ) /g as dl-semet and supplemented with 0 , 0.3 , 0.6 or 1.2 % dl-methionine . | NA | {
"id": "C0036584",
"name": "dl-semet",
"pos": [
227,
235
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
284,
294
]
} |
in a second experiment , 75semet was injected into weanling male rats which had been fed the basal diet containing 2.0 micrograms selenium as dl-semet with or without the addition of 1.0 % methionine . | NA | {
"id": "C0036584",
"name": "dl-semet",
"pos": [
142,
150
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
189,
199
]
} |
these data suggest that methionine diverts semet from incorporation into general proteins and enhances its conversion to selenocysteine for specific selenium-requiring proteins , such as gshpx . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
24,
34
]
} | {
"id": "C0036584",
"name": "semet",
"pos": [
43,
48
]
} |
kittens fed a -pn diet had depressed body weight gain , food intake , plasma pyridoxal phosphate ( plp ) and pyridoxal ( pl ) , hb and hematocrit , and had elevated urinary oxalate , plasma tyrosine and plasma cystathionine . | NA | {
"id": "C0034272",
"name": "diet",
"pos": [
18,
22
]
} | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
77,
96
]
} |
at the end of the repletion period , kittens fed 1.0 mg pn/kg diet had lower body weight gain , higher plasma tyrosine and cystathionine , slower rate of decrease in urinary oxalate , and lower values for hb , hematocrit and plp than did the kittens from groups fed 2.0-8.0 mg pn/kg diet . | NA | {
"id": "C0034266",
"name": "plp",
"pos": [
225,
228
]
} | {
"id": "C0034272",
"name": "diet",
"pos": [
283,
287
]
} |
body protein and energy accretion in response to dietary protein level in mice from weaning to maturity . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
5,
12
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
49,
64
]
} |
at every dietary protein level , the protein accretion rose rapidly with age to attain a maximum at about 7 d after weaning , when it depended on the dietary protein level , then decreased markedly to where differences due to dietary protein level became negligible . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
17,
24
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
226,
241
]
} |
another selenoprotein , designated selenoprotein p , has been found in rat plasma and has been quantitated . | NA | {
"id": "C0074302",
"name": "selenoprotein",
"pos": [
8,
21
]
} | {
"id": "C0141947",
"name": "selenoprotein p",
"pos": [
35,
50
]
} |
understanding the nutritional effects of selenium will require better characterization of glutathione peroxidase , selenoprotein p and other selenoproteins . | NA | {
"id": "C0141947",
"name": "selenoprotein p",
"pos": [
115,
130
]
} | {
"id": "C0074302",
"name": "selenoproteins",
"pos": [
141,
155
]
} |
in the second study the wm diet was fed again , and the two control diets contained casein as the protein source , 20 % butter oil ( so that the level of dietary fat was comparable to that of the wm diet ) , and either lactose or sucrose was added . | NA | {
"id": "C0006494",
"name": "butter",
"pos": [
120,
126
]
} | {
"id": "C0012171",
"name": "dietary fat",
"pos": [
154,
165
]
} |
the main ingredients in this new methodology are bonded-phase silica for quantitative angiotensin extraction from biological fluids and antibodies with a high affinity to angiotensin ii to provide for the sensitivity of the radio-immunoassay , high performance liquid chromatography to guarantee the specificity for the angiotensin- ( 1-8 ) octapeptide , and a renin inhibitor in the blood sampling tube to prevent any in vitro angiotensin ii generation . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
86,
97
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
428,
442
]
} |
most affected patients accumulated long-chain fatty alcohol in plasma , with a greater relative accumulation of octadecanol ( mean threefold greater than normal ) than hexadecanol ( mean twofold greater than normal ) . | NA | {
"id": "C0015694",
"name": "fatty alcohol",
"pos": [
46,
59
]
} | {
"id": "C0075206",
"name": "octadecanol",
"pos": [
112,
123
]
} |
in fact , they tended to stimulate pg output during this 20-min period , with cycloheximide having a pronounced effect on pge-2 output . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
35,
37
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
122,
125
]
} |
the synthesis of secreted proteins , but not of cellular proteins , was greater by day-15 than by day-7 endometrium in culture . | NA | {
"id": "C0034861",
"name": "synthesis",
"pos": [
4,
13
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
57,
65
]
} |
our data suggest that ebv might be the immunogen for apf , an antibody , until now considered to be an autoantibody . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
62,
70
]
} | {
"id": "C0004358",
"name": "autoantibody",
"pos": [
103,
115
]
} |
chemical delivery systems ( cds 's ) based on a dihydropyridine -- -- quaternary pyridinium ion redox system analogous to the naturally occurring nadh -- -- nad+ system were synthesized for a group of staphylococcal penicillinase resistant penicillins , including methicillin , oxacillin , cloxacillin , and dicloxacillin , in order to improve their penetration of the central nervous system ( cns ) . | NA | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
278,
287
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
310,
321
]
} |
chemical delivery systems ( cds 's ) based on a dihydropyridine -- -- quaternary pyridinium ion redox system analogous to the naturally occurring nadh -- -- nad+ system were synthesized for a group of staphylococcal penicillinase resistant penicillins , including methicillin , oxacillin , cloxacillin , and dicloxacillin , in order to improve their penetration of the central nervous system ( cns ) . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
290,
301
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
308,
321
]
} |
six of them were prepared following a novel synthetic route starting from the l-amino acid alanine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
80,
90
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
91,
98
]
} |
new model for the secondary structure of the 5 ' non-coding rna of poliovirus is supported by biochemical and genetic data that also show that rna secondary structure is important in neurovirulence . | NA | {
"id": "C0887909",
"name": "non-coding rna",
"pos": [
49,
63
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
143,
146
]
} |
when hl60 or kb cells were treated with mab 42/6 combined with ga nitrate , mab 42/6 increased cytotoxicity of ga for hl60 cells but had little or no effect on ga cytotoxicity to kb cells . | NA | {
"id": "C0061008",
"name": "ga nitrate",
"pos": [
63,
73
]
} | {
"id": "C0016980",
"name": "ga",
"pos": [
160,
162
]
} |
in isolated , hemoglobin-free perfused livers of fasted rats , formaldehyde at an initial concentration of 10 mmol/l produced toxicity as evidenced by a release of enzymes ( gpt , sdh ) and of glutathione ( mainly gssg ) into the perfusate , an accumulation of calcium in the liver , and a depletion of hepatic glutathione . | NA | {
"id": "C0061516",
"name": "gssg",
"pos": [
214,
218
]
} | {
"id": "C0017817",
"name": "glutathione",
"pos": [
311,
322
]
} |
the hepatotoxic action of formaldehyde is not due to its metabolism to formate or to the 10 % methanol added as a stabilizing agent to the commercially available 37 % solution named formalin . | NA | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
26,
38
]
} | {
"id": "C0949307",
"name": "formalin",
"pos": [
182,
190
]
} |
bis-2-chloroethyl sulfide- ( bces- ) induced dna cross-links in confluent , primary cultures of newborn rat cutaneous epidermal keratinocytes were detected using an assay that includes in situ unwinding of the dna followed by separation of single-stranded dna and double-stranded dna ( dsdna ) with hydroxylapatite . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
240,
259
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
264,
283
]
} |
in a multivariate logistic regression model , a vitamin a level less than 5 micrograms/dl was associated with fatal outcome for children younger than 24 months old ( relative risk = 2.9 , 95 per cent ci 1.3 , 6.8 ) , but not for older children . | NA | {
"id": "C0008059",
"name": "children",
"pos": [
128,
136
]
} | {
"id": "C1455726",
"name": "older children",
"pos": [
229,
243
]
} |
[ studies of trichloroethylene-induced glycosuria : blood glucose and renal glucose reabsorption in rats exposed to trichloroethylene ] . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
52,
65
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
76,
83
]
} |
the capacity of the sera to accumulate intracellular cholesterol was unrelated to the levels of total cholesterol , high density lipoprotein cholesterol , apo-b or apo-ai , taken separately , but showed a weak correlation to the apo-b/apo-ai ratio . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
53,
64
]
} | {
"id": "C0023822",
"name": "high density lipoprotein cholesterol",
"pos": [
116,
152
]
} |
a study of 35 patients with uncomplicated essential hypertension ( eh ) ( labile hypertension , stages ib-iia or stable hypertension , stage iib ) demonstrated a higher rate of na+-li+ countertransport in patients with hypertensive hereditary predisposition to eh ( group 1 ) , as compared to those with unaggravated heredity ( group 2 ) . | NA | {
"id": "C0262534",
"name": "labile",
"pos": [
74,
80
]
} | {
"id": "C0020538",
"name": "hypertension",
"pos": [
120,
132
]
} |
blood gaseous composition , mechanisms controlling hemoglobin affinity to oxygen and hemoglobin effects of a single captopril dose were assessed in 124 patients with chronic heart failure ( chf ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
51,
61
]
} | {
"id": "C0019016",
"name": "hemoglobin",
"pos": [
85,
95
]
} |
the electrophysiological mechanism of the control of tachycardia by finoptin was the antegrade block of impulse conduction through the atrioventricular node in 21 ( 95.5 % ) patients , and retrograde block of the complementary atrioventricular pathway in 1 ( 4.5 % ) patient . | NA | {
"id": "C0018794",
"name": "block",
"pos": [
95,
100
]
} | {
"id": "C0004245",
"name": "block",
"pos": [
200,
205
]
} |
plasma concentrations of free and sulfoconjugated dopamine , epinephrine , and norepinephrine in healthy infants and children . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
61,
72
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
79,
93
]
} |
low urinary excretion of cysteinylglycine , cyst ( e ) ine , taurine , n-acetylcysteine , mercaptolactate and mercaptoacetate and reduced leukocyte taurine levels constituted additional evidence of decreased intracellular availability of cysteine , i.e . glutathione . | NA | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
71,
87
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
238,
246
]
} |
the results indicate that n-acetylcysteine may be of value in increasing the low intracellular glutathione concentrations and cysteine availability in patients with hereditary glutathione synthetase deficiency . | NA | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
26,
42
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
126,
134
]
} |
correction of sphingomyelinase deficiency in niemann-pick type c fibroblasts by removal of lipoprotein fraction from culture media . | NA | {
"id": "C0028064",
"name": "sphingomyelinase deficiency",
"pos": [
14,
41
]
} | {
"id": "C0220756",
"name": "niemann-pick type c",
"pos": [
45,
64
]
} |
the average sphingomyelinase activity of fibroblasts obtained from 12 niemann-pick type c patients was 37.9 % of that of normal fibroblasts ( 27.2 versus 72 nmol ( mg protein ) -1 h-1 ) when the cells were cultured in minimum essential medium containing 13 % fetal bovine serum . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
195,
200
]
} |
urea inhibition of urinary n-acetyl-beta-d-glucosaminidase ( nag ) was examined with human isoenzymes and total enzyme in urine . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
91,
101
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
112,
118
]
} |
the concentrations of anaphylatoxins ( c3a and c5a ) were measured with a radioimmunoassay and the activity of their inactivator was determined . | NA | {
"id": "C0002791",
"name": "anaphylatoxins",
"pos": [
22,
36
]
} | {
"id": "C0009510",
"name": "c3a",
"pos": [
39,
42
]
} |
a clinical trial of sequential tamoxifen and medroxyprogesterone acetate ( mpa ) was carried out in 36 women with metastatic breast cancer in order to evaluate the therapeutic efficacy of this regimen and to determine if tamoxifen would increase progesterone receptor ( pr ) levels and thereby increase response to mpa . | NA | {
"id": "C0065864",
"name": "medroxyprogesterone acetate",
"pos": [
45,
72
]
} | {
"id": "C0025147",
"name": "mpa",
"pos": [
315,
318
]
} |
all rabbits subject to occlusion of the left circumflex artery below where it emerges from under the left atrial appendage had ecg changes ( st-segment elevation , lead ii ) , 80 % had arrhythmias , and 50 % died in ventricular fibrillation during the first 20 min of coronary artery occlusion . | NA | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
185,
196
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
216,
240
]
} |
oral magnesium therapy ( magnesium aspartate hcl ) attenuated pulmonary hypertension and right ventricular hypertrophy in 100 % of the wistar rats studied . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
5,
14
]
} | {
"id": "C0543448",
"name": "magnesium aspartate",
"pos": [
25,
44
]
} |
left adrenal pheochromocytoma and mesenteric paraganglioma were diagnosed in a 52-year-old female with diabetes mellitus ( fasting blood glucose 14.5 mmol/l ) , hypertension and myocardial asymmetric septal hypertrophy ( septal/left ventricular free wall thickness 1.31 ) . | NA | {
"id": "C0031511",
"name": "adrenal pheochromocytoma",
"pos": [
5,
29
]
} | {
"id": "C0030421",
"name": "paraganglioma",
"pos": [
45,
58
]
} |
the modulation of histocompatibility antigens ( hla ) expression by four different agents ( gamma-ifn , lps , pma and 5-azac ) was investigated on a human tumor derived cell line that did not constitutively express hla class i and class ii molecules on its surface . | NA | {
"id": "C0019628",
"name": "histocompatibility antigens",
"pos": [
18,
45
]
} | {
"id": "C0019629",
"name": "hla class i",
"pos": [
215,
226
]
} |
gamma interferon and lps induced hla-dr and hla-dp , but not hla-dq class ii nor hla class i antigens , while phorbol ester was unable to induce either class i or ii molecule expression of the hla system . | NA | {
"id": "C0019630",
"name": "hla",
"pos": [
33,
36
]
} | {
"id": "C0019628",
"name": "hla",
"pos": [
193,
196
]
} |
gamma interferon and lps induced hla-dr and hla-dp , but not hla-dq class ii nor hla class i antigens , while phorbol ester was unable to induce either class i or ii molecule expression of the hla system . | NA | {
"id": "C0019629",
"name": "hla class i",
"pos": [
81,
92
]
} | {
"id": "C0019628",
"name": "hla",
"pos": [
193,
196
]
} |
of the 10 infants with raised hepatic glycogen who had a diagnosis of sids , 8 had glucose-6-phosphatase deficiency ( type 1a glycogen storage disease ) , and 2 had transport protein t2 deficiency ( type 1c glycogen storage disease ) . | NA | {
"id": "C0017920",
"name": "glucose-6-phosphatase",
"pos": [
83,
104
]
} | {
"id": "C0017919",
"name": "glycogen storage disease",
"pos": [
207,
231
]
} |
among patients at high risk of infection ( with or without liver disease ) anti-hcv antibodies were found in 85 % of prospectively followed patients with post-transfusion non-a , non-b hepatitis , 62 % of patients with chronic hepatitis or cirrhosis and a history of blood transfusion , 70 % of haemophiliacs receiving replacement therapy , 70 % of intravenous drug abusers , and 20 % of haemodialysis patients . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
59,
72
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
240,
249
]
} |
survival characteristics were determined for head and neck patients according to lymph node surgery , histologic type of tumor , and tumor thickness . | NA | {
"id": "C0027652",
"name": "histologic type of tumor",
"pos": [
102,
126
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
133,
138
]
} |
cholesterol content and cholesterol storage as cholesteryl ester in male liver are consistent with the activity of hmg-coa reductase and of acat enzymes . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
0,
11
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
47,
64
]
} |
cholesteryl ester content of the hepatocytes from dietary ( old ) commercial cholesterol-fed rabbits was dramatically increased in comparison with hepatocytes from control and purified cholesterol-fed rabbits . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
0,
17
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
185,
196
]
} |
the elevated intracellular cholesteryl ester content is assumed to account for such an increase of very low density lipoprotein-cholesteryl ester secretion by cells prepared from dietary ( old ) commercial cholesterol-fed rabbits . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
27,
44
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
206,
217
]
} |
the rapid development of hypercholesterolemia induced by dietary ( old ) commercial cholesterol is associated , at least in part , with the stimulated production of hepatic very low density lipoprotein apolipoproteins and cholesteryl esters . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
30,
41
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
222,
240
]
} |
these differences in the relationships of the two tocopherols to lipids and lipoproteins support the view that when the two tocopherols are present at normal dietary levels , gamma-tocopherol partitions between lipoproteins based on their relative lipid content , but a portion of the alpha-tocopherol in high density lipoprotein is specifically bound . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
76,
88
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
248,
253
]
} |
fish oil prevents change in arachidonic acid and cholesterol content in rat caused by dietary cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
49,
60
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
86,
105
]
} |
fish oil accentuates the 20:4 omega 6 lowering effect of dietary cholesterol and appears to prevent accumulation of cholesterol in plasma and tissue lipids under a high dietary load of cholesterol . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
57,
76
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
185,
196
]
} |
the fatty acid composition of liver triglycerides , free fatty acids , cholesteryl esters , phosphatidylinositol , phosphatidylserine , cardiolipin , phosphatidylcholine and phosphatidylethanolamine were determined . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
52,
56
]
} |
immunization with plps induced significant levels of anti-lps and anti-epitope c antibodies but wlps was not antigenic . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
71,
78
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
109,
118
]
} |
pmn elastase also removed the cell surface receptors for exoa and dt on chinese hamster ovary cells , suggesting that both toxins may be ineffective at local sites of severe inflammation . | NA | {
"id": "C0015309",
"name": "exoa",
"pos": [
57,
61
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
123,
129
]
} |
fly-ashes were found to exhibit different fibrogenic effects , yet , their fibrogenic activity was weaker , compared to quartz sands . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
120,
126
]
} | {
"id": "C0037098",
"name": "sands",
"pos": [
127,
132
]
} |
long-term and withdrawal effects of two different oestrogen-progestogen combinations on lipid and lipoprotein profiles in post-menopausal women . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
88,
93
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
98,
109
]
} |
this may be due to the state of a certain immune deficiency characteristic of parasitic diseases , including helminthiasis . | NA | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
78,
96
]
} | {
"id": "C0018889",
"name": "helminthiasis",
"pos": [
109,
122
]
} |
transcription of the major ribosomal rna appears to involve coupling between adjacent transcription units , which are separated by the 5s rna transcription unit . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
27,
40
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
138,
141
]
} |
these constructions were transiently expressed in placental , fibroblast , or islet cell lines to identify regulatory sequences involved in cell-specific expression as well as interactions between the ure , the cre , and different promoter elements . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
62,
72
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
140,
144
]
} |
estrogen had no effect on the splicing or selection of polyadenylation sites on the 3'-utr as determined by high resolution gel analysis of the 3'-utr and dna sequencing of cdna clones isolated from a liver library from an estrogen-treated male xenopus . | NA | {
"id": "C0600600",
"name": "3",
"pos": [
84,
85
]
} | {
"id": "C0600680",
"name": "utr",
"pos": [
147,
150
]
} |
desensitization of the protein kinase-c dependent pathway by prolonged exposure of cells to phorbol esters eliminates the tpa-induced transcription by tre and inhibits the tpa-induced component of the synergistic response to both camp and tpa . | NA | {
"id": "C0031586",
"name": "phorbol esters",
"pos": [
92,
106
]
} | {
"id": "C0039654",
"name": "tpa",
"pos": [
239,
242
]
} |
although models for the interaction of tfiiia with the 5s-ribosomal gene dna have been proposed , based on nuclease digestion and methylation interference data , little precise structural information is available for tfiiia and the physical basis for the interaction of zinc-fingers with dna is not understood . | NA | {
"id": "C0012933",
"name": "ribosomal",
"pos": [
58,
67
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
288,
291
]
} |
fibrinolytic results demonstrated that both plasminogen and alpha 2-plasmin inhibitor were decreased , and both fibrinopeptide b beta 15-42 and fibrin and fibrinogen degradation products were increased in the hematomas . | NA | {
"id": "C0015982",
"name": "fibrin",
"pos": [
0,
6
]
} | {
"id": "C0163275",
"name": "fibrinogen degradation",
"pos": [
155,
177
]
} |
their clinical behavior is unpredictable and their prognosis has been regarded as intermediate between that of astrocytomas and glioblastomas . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
111,
123
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
128,
141
]
} |
acrophases were located at 14.21 hours ( range 11.11-16.25 ) for urinary total protein , at 17.27 hours ( 13.14-22.31 ) for serum total protein , at 15.13 hours ( 13.01-18.04 ) for urinary albumin , at 14.18 hours ( 11.13-19.20 ) for serum albumin , at 21.22 hours ( 18.42-02.41 ) for urinary retinol-binding protein , at 14.51 hours ( 08.52-19.57 ) for serum retinol-binding protein , and at 16.17 hours ( 13.38-19.25 ) for creatinine clearance . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
189,
196
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
234,
247
]
} |
these findings suggest that circadian rhythms of urinary total protein and urinary albumin are influenced by changes in gfr , which occur also independently from an oral protein load . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
83,
90
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
170,
177
]
} |
the results obtained have shown that the test is effective for detection of preglaucoma and ocular hypertension as well as for differential diagnosis of initial glaucoma and ophthalmic hypertension by the analysis of changes of the blind spot area , the time of restoration of its sizes to the initial state and dynamics of annular compression coefficients at the time of the test . | NA | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
79,
87
]
} | {
"id": "C0028840",
"name": "ophthalmic hypertension",
"pos": [
174,
197
]
} |
both the 4f2 antigen , which is implicated in the control of ht1080 cell proliferation , and heterodimers of the two chains ( alpha and beta ) of the il2 receptor ( il2-r ) are expressed in embryonic and ht1080 cells , but not in normal adult fibroblasts or in the revertant cell lines . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
243,
254
]
} |
the behavior of these membrane markers strengthens the hypothesis that ht1080 cells may represent a block in the differentiation pathway of fibroblastic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
78,
83
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
140,
152
]
} |
several classes of oncogenes were tested for their ability to confer cellular growth autonomy and the metastatic phenotype on ccl39 lung fibroblasts . v-sis as well as highly but not weakly expressed activated ras , v-fps and myc genes were susceptible to relieve ccl39 cells from their dependence on exogenous growth factors . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
137,
148
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
270,
275
]
} |
in order to document a possible involvement of structural alterations of fgf ( fibroblast growth factor ) -like genes in human oncogenesis , we have screened a large series of human tumors for amplification of five fgf-related genes ( basic-fgf , int2 , hst , fgf5 and fgf6 ) . | NA | {
"id": "C0016026",
"name": "fgf",
"pos": [
73,
76
]
} | {
"id": "C0117720",
"name": "fgf5",
"pos": [
260,
264
]
} |
we studied the molecular structure of the bcl-1 gene in eight b-cell nhl tumors that exhibited a break at 11q13 . | NA | {
"id": "C0079731",
"name": "b-cell",
"pos": [
62,
68
]
} | {
"id": "C0024305",
"name": "nhl",
"pos": [
69,
72
]
} |
because they did not fit the cibp definition , patients with the following primary treatment diagnoses were eliminated : degenerative disease of the spine and spinal stenosis ; | NA | {
"id": "C0037933",
"name": "disease of",
"pos": [
134,
144
]
} | {
"id": "C0037944",
"name": "spinal stenosis",
"pos": [
159,
174
]
} |
cervical and low back pain patients were found to be more accurate than headache and abdominal pain patients in remembering their pain . | NA | {
"id": "C0018681",
"name": "headache",
"pos": [
72,
80
]
} | {
"id": "C0030193",
"name": "pain",
"pos": [
130,
134
]
} |
in poisoning by carbon tetrachloride stimulated secretion decreases progressively , while basal secretion reduces in the initial stages of perfusion but begins to be activated by the 12th month after the onset of poisoning . | NA | {
"id": "C0392622",
"name": "poisoning",
"pos": [
3,
12
]
} | {
"id": "C0032343",
"name": "poisoning",
"pos": [
213,
222
]
} |
in conclusion , the bemegride loading imp-spect study could be a potential diagnostic method in patients with seizures whose epileptic lesions were not determined by the conventional methods or in whom the surgical interventions were considered , by reason of its capability to demonstrate positively the epileptic lesions . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
110,
118
]
} | {
"id": "C0014544",
"name": "epileptic",
"pos": [
305,
314
]
} |
crf-stimulated adenylate cyclase activity was evident in the presence of guanosine-5'-triphosphate ( gtp ) and its precursor guanosine-5'-diphosphate ( gdp ) but was not detected in the presence of the hydrolysis-resistant gtp analogs , guanyl-5'-imidodiphosphate [ gpp ( nh ) p ] and guanosine-5'-gamma-thiotriphosphate ( gtp-gamma-s ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
101,
104
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
266,
278
]
} |
morphine and the molluscan neuropeptide phe-met-arg-phe-nh2 ( fmrfamide ) were administered to mice alone or in combination intracerebroventricularly ( icv ) and the effect on locomotor activity was measured . | NA | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
27,
39
]
} | {
"id": "C0060608",
"name": "fmrfamide",
"pos": [
62,
71
]
} |
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