text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
mitral valve prolapse is associated with thoracic bony abnormalities , low body weight , low blood pressure , and a modest excess of orthostatic hypotension , syncope , palpitations , and atrial arrhythmias , but not with nonspecific symptoms ( atypical chest pain , dyspnea , anxiety or panic attacks ) . | NA | {
"id": "C0020649",
"name": "low blood pressure",
"pos": [
89,
107
]
} | {
"id": "C0020651",
"name": "orthostatic hypotension",
"pos": [
133,
156
]
} |
inhalation anaesthetics -- exposure and control : a statistical comparison of personal exposures in operating theatres with and without anaesthetic gas scavenging . | NA | {
"id": "C0242903",
"name": "inhalation anaesthetics",
"pos": [
0,
23
]
} | {
"id": "C0002932",
"name": "anaesthetic",
"pos": [
136,
147
]
} |
2 ) selective deficiencies in immune globulins ( iga deficiency , igm deficiency , deficiencies in igg sub-classes , dysgammaglobulinemias ) ; | NA | {
"id": "C0162538",
"name": "iga",
"pos": [
49,
52
]
} | {
"id": "C0013374",
"name": "dysgammaglobulinemias",
"pos": [
117,
138
]
} |
2 ) selective deficiencies in immune globulins ( iga deficiency , igm deficiency , deficiencies in igg sub-classes , dysgammaglobulinemias ) ; | NA | {
"id": "C0162539",
"name": "deficiencies",
"pos": [
14,
26
]
} | {
"id": "C0013374",
"name": "dysgammaglobulinemias",
"pos": [
117,
138
]
} |
incubation of cells with 25-oh resulted in a four-fold increase in cholesterol esterifying activity but no effect on cholesteryl ester hydrolytic activity . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
67,
78
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
117,
134
]
} |
at high levels of aminoglycoside exposure , linear regression analysis disclosed that the rank order of toxicity of the aminoglycosides to be : neomycin greater than kanamycin greater than gentamicin greater than streptomycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
120,
135
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
189,
199
]
} |
at high levels of aminoglycoside exposure , linear regression analysis disclosed that the rank order of toxicity of the aminoglycosides to be : neomycin greater than kanamycin greater than gentamicin greater than streptomycin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
120,
135
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
213,
225
]
} |
with the exception of neomycin , clear evidence was obtained that toxicity and cell regeneration were occurring simultaneously throughout the time course of aminoglycoside exposure ; | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
22,
30
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
157,
171
]
} |
in addition , the hpt cells exposed to gentamicin displayed a unique pattern of toxicity and cell regeneration when compared to the other aminoglycosides tested , with gentamicin having an increased ability to stimulate cell proliferation . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
138,
153
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
168,
178
]
} |
reduced birth weight , growth and psychomotor retardation , craniofacial dysmorphism with microcephaly and low set , deformed ears , stubby nose , wide set nipples , congenital heart defect and undescended testes were the main clinical findings . | NA | {
"id": "C0376634",
"name": "craniofacial dysmorphism",
"pos": [
60,
84
]
} | {
"id": "C0025958",
"name": "microcephaly",
"pos": [
90,
102
]
} |
partial monosomy of 22q , resulting from a de novo unbalanced translocation t ( x ; 22 ) ( q28 ; q11 ) was detected in a newborn female with manifestations of the digeorge anomaly including multiple anomalies , type i truncus arteriosus , t-cell abnormalities , thymic aplasia and parathyroid hypoplasia noted on postmortem examination . | NA | {
"id": "C0000772",
"name": "multiple anomalies",
"pos": [
190,
208
]
} | {
"id": "C0000768",
"name": "abnormalities",
"pos": [
246,
259
]
} |
however , amino acid utilization and biosynthesis , ammonia assimilation , purine and pyrimidine metabolism and biosynthesis of delta-aminolevulinic acid as precursor of bacteriochlorophylls and hemes are topics of vital importance . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
10,
20
]
} | {
"id": "C0002563",
"name": "delta-aminolevulinic acid",
"pos": [
128,
153
]
} |
this review focuses on utilization of amino acids as n- and c/n-sources , the pathways of purine and pyrimidine degradation , novel aspects of amino acid biosynthesis ( with emphasis on branched-chain amino acids and delta-aminolevulinic acid ) and some aspects of ammonia assimilation and glutamate synthesis by purple bacteria , green sulfur bacteria and chloroflexus aurantiacus . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
186,
212
]
} |
this review focuses on utilization of amino acids as n- and c/n-sources , the pathways of purine and pyrimidine degradation , novel aspects of amino acid biosynthesis ( with emphasis on branched-chain amino acids and delta-aminolevulinic acid ) and some aspects of ammonia assimilation and glutamate synthesis by purple bacteria , green sulfur bacteria and chloroflexus aurantiacus . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0002563",
"name": "delta-aminolevulinic acid",
"pos": [
217,
242
]
} |
several porphyrins were investigated and ranked by the intensity of their esr spectra ( coproporphyrin iii greater than coproporphyrin i greater than deuteroporphyrin ix greater than mesoporphyrin ix greater than photofrin ii greater than protoporphyrin ix greater than uroporphyrin i greater than uroporphyrin iii greater than hematoporphyrin ix ) . | NA | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
8,
18
]
} | {
"id": "C0033733",
"name": "protoporphyrin ix",
"pos": [
239,
256
]
} |
the porphyrins were oxidized by several peroxidases ( horseradish peroxidase , lactoperoxidase , and myeloperoxidase ) , yielding the same type of esr spectra . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
40,
51
]
} | {
"id": "C0019941",
"name": "horseradish peroxidase",
"pos": [
54,
76
]
} |
the porphyrins were oxidized by several peroxidases ( horseradish peroxidase , lactoperoxidase , and myeloperoxidase ) , yielding the same type of esr spectra . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
40,
51
]
} | {
"id": "C0022948",
"name": "lactoperoxidase",
"pos": [
79,
94
]
} |
the porphyrins were oxidized by several peroxidases ( horseradish peroxidase , lactoperoxidase , and myeloperoxidase ) , yielding the same type of esr spectra . | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
40,
51
]
} | {
"id": "C0027021",
"name": "myeloperoxidase",
"pos": [
101,
116
]
} |
in this study the complete amino acid sequence and the position of disulfide bridges of the purified protein were determined by automated edman degradation of the protein and its tryptic , chymotryptic , and staphylococcus aureus v8 protease peptides and were as follows : ( sequence ; see text ) computer analysis revealed the presence of 40-50 % sequence identity between inducible cysteine proteinase inhibitor and cystatins from human saliva , human cystatin c , bovine cystatins , and chicken cystatins , all members of family 2 cystatins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} | {
"id": "C0010646",
"name": "cystatins",
"pos": [
534,
543
]
} |
in this study the complete amino acid sequence and the position of disulfide bridges of the purified protein were determined by automated edman degradation of the protein and its tryptic , chymotryptic , and staphylococcus aureus v8 protease peptides and were as follows : ( sequence ; see text ) computer analysis revealed the presence of 40-50 % sequence identity between inducible cysteine proteinase inhibitor and cystatins from human saliva , human cystatin c , bovine cystatins , and chicken cystatins , all members of family 2 cystatins . | NA | {
"id": "C0071744",
"name": "cystatin c",
"pos": [
454,
464
]
} | {
"id": "C0010646",
"name": "cystatins",
"pos": [
534,
543
]
} |
in vivo tracer kinetic studies demonstrated that in the rat 1,25-d3 and 1,25-d2 kinetics were similar , whereas 24-epi-1,25-d2 had a 25 % shorter plasma half-life and was cleared from the body 2.8 times faster than the natural hormones . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
80,
88
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
153,
162
]
} |
of the 18 steroids tested , progesterone , 17 alpha-hydroxyprogesterone , and 11 beta,17 alpha-dihydroxyprogesterone were found to be the only steroids to serve as substrates for this adrenal enzyme , a much higher degree of substrate specificity than has been reported for a hepatic 21-hydroxylase . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
28,
40
]
} | {
"id": "C0002328",
"name": "dihydroxyprogesterone",
"pos": [
95,
116
]
} |
a very small amount of complex was found in kidney of control rats , accounting for only 1-3 % of total enzyme in the tissue , while in thymus , approximately one-third of the total ornithine decarboxylase in thymus occurred as an antizyme-enzyme complex . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
104,
110
]
} | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
240,
254
]
} |
histologic examination of subcutaneous masses has identified a variety of lipomatous , hamartomatous , and angiomatous tumors . | NA | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
87,
100
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
119,
125
]
} |
patients with true ampullary tumors producing predominantly sialomucins had a better prognosis than those with tumors secreting sulphated mucins ( p = 0.045 ) , but the numbers were small . | NA | {
"id": "C0074477",
"name": "sialomucins",
"pos": [
60,
71
]
} | {
"id": "C0026682",
"name": "mucins",
"pos": [
138,
144
]
} |
the cells proliferated in response to autologous , but not allogeneic melanoma cells , in a dose-dependent manner . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
59,
69
]
} |
lipopolysaccharide ( lps , endotoxin ) administration to human subjects elicits significant elevations in plasma cachectin/tnf , epinephrine , and cortisol . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
21,
24
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
27,
36
]
} |
these data demonstrate that adenosine administered in these concentrations provides myocardial protection and improved recovery of both systolic and diastolic function after global ischemia , presumably metabolically by reducing depletion of adenosine triphosphate or enhancing repletion of adenosine triphosphate and enabling improved postischemic recovery . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
28,
37
]
} | {
"id": "C0001480",
"name": "adenosine",
"pos": [
291,
300
]
} |
the patients were either on clomiphene + human menopausal gonadotrophin or follicle stimulating hormone + human menopausal gonadotrophin stimulation regimens . | NA | {
"id": "C0524639",
"name": "follicle stimulating hormone",
"pos": [
75,
103
]
} | {
"id": "C0025326",
"name": "menopausal gonadotrophin",
"pos": [
112,
136
]
} |
large i.v . doses of mg salts ( i.e. , greater than 20 mumoles/min ) induced some bleeding from the venules which varied with the anion . | NA | {
"id": "C0021966",
"name": "i",
"pos": [
6,
7
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
130,
135
]
} |
neither adrenaline nor noradrenaline relaxed the ascaris muscle but gamma-aminobutyric acid ( gaba ) and , occasionally , piperazine caused immediate relaxation of the muscle . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
8,
18
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
23,
36
]
} |
the importance of this feature lies in the possible confusion histologically with inflammatory bowel disease , especially crohn 's disease . | NA | {
"id": "C0021390",
"name": "inflammatory",
"pos": [
82,
94
]
} | {
"id": "C0010346",
"name": "crohn 's disease",
"pos": [
122,
138
]
} |
tumor bioptic material from five tumor patients was tested with various monoclonal antibodies , following which the highly reactive antibodies were selected and incubated with the patient 's lak cells . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
72,
93
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
132,
142
]
} |
recurrent pancreatitis in the third trimester in 2 consecutive pregnancies -- its relationship to liver histology : a case report . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
30,
45
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
63,
74
]
} |
a 20-year-old woman who had recurrent pancreatitis in the third trimester in 2 consecutive pregnancies was reported . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
58,
73
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
91,
102
]
} |
amino acid analysis indicated 12 % basic amino acids , 14 % acidic amino acids and 16 % glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0301714",
"name": "basic amino acids",
"pos": [
35,
52
]
} |
amino acid analysis indicated 12 % basic amino acids , 14 % acidic amino acids and 16 % glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
60,
78
]
} |
amino acid analysis indicated 12 % basic amino acids , 14 % acidic amino acids and 16 % glycine . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
88,
95
]
} |
synthetic kinin standards isoleucine-seryl-bradykinin ( ileu-ser-bk ) , methionyl-lysyl-bradykinin ( met-lys-bk ) , tyrosine-bradykinin ( tyr-bk ) and bradykinin ( bk ) yielded almost identical curves with a mixture of a5 and d9 monoclonal antibodies . | NA | {
"id": "C0022474",
"name": "lysyl-bradykinin",
"pos": [
82,
98
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
151,
161
]
} |
therefore we tried to quantify dd and diazepam ( d ) in animals during maturation ( e.g . hen , chicken , eggs ) , in brain of species at different evolutionary stages e.g . salmon , frog , monitor/reptile , rat , cat , dog , deer , bovine ) including newborn and adult humans . | NA | {
"id": "C0011279",
"name": "dd",
"pos": [
31,
33
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
38,
46
]
} |
( s ) -emopamil was tested in comparison to verapamil and gallopamil for calcium and serotonin antagonism and for cerebroprotective activity in acute hypoxia/ischemia . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
44,
53
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
58,
68
]
} |
in rat cerebrocortical membranes , its affinity ( ki = 38 nmol/l ) equalled that of verapamil and gallopamil ( ki = 49 and 27 nmol/l , respectively ) , whereas it was somewhat weaker in guinea pig skeletal muscle membranes . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
84,
93
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
98,
108
]
} |
its ki value ( 4.4 nmol/l ) for 3h-ketanserin displacement being substantially lower than that of verapamil and gallopamil ( ki = 177 and 242 nmol/l , respectively ) . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
98,
107
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
112,
122
]
} |
( s ) -emopamil 's serotonin antagonistic efficacy ( ec50 = 4.5 nmol/l ) was an order of magnitude higher than that of verapamil and gallopamil . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
119,
128
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
133,
143
]
} |
( s ) -emopamil has a less potent calcium antagonistic effect ( ec50 = 270 nmol/l ) on the aorta than verapamil and gallopamil ( ec50 = 35 and 14 nmol/l , respectively ) . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
102,
111
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
116,
126
]
} |
in isolated electrically driven ( 1 hz ) left atria of guinea pigs , ( s ) -emopamil inhibited contractile force at a much higher concentration ( ec50 = 29 mumol/l ) than verapamil and gallopamil ( ec50 = 1.1 and 0.19 mumol/l , respectively ) . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
171,
180
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
185,
195
]
} |
the relative cerebral concentration defined in this way amounted to 2.05 for emopamil , 0.11 for verapamil and 0.03 ml/g for gallopamil , corresponding to a ratio of 70:4:1 . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
97,
106
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
125,
135
]
} |
relative to the water the following brain uptake indices were obtained : ( s ) -emopamil 110.3 , gallopamil 45.3 and verapamil 40.6 % . | NA | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
97,
107
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
117,
126
]
} |
according to these figures , emopamil is clearly superior to verapamil and gallopamil both with regard to cerebral availability and blood-brain barrier permeability . | NA | {
"id": "C0042523",
"name": "verapamil",
"pos": [
61,
70
]
} | {
"id": "C0016986",
"name": "gallopamil",
"pos": [
75,
85
]
} |
the biotransformation of an epimeric form of the anticholinergic drug exo-2-phenyl-bicyclo- [ 2.2.1 . ] -heptane-2-carboxylic acid ( 4'-diethylaminopropyl ) ester hydrochloride ( bornaprine hydrochloride , sormodren ) was investigated after oral application in male wistar rats . | NA | {
"id": "C0007066",
"name": "carboxylic acid",
"pos": [
115,
130
]
} | {
"id": "C0014898",
"name": "ester",
"pos": [
157,
162
]
} |
the time courses of dissociation of the unlabeled dihydropyridines from the vascular binding sites were investigated using 3h-nitrendipine . | NA | {
"id": "C0012315",
"name": "dihydropyridines",
"pos": [
50,
66
]
} | {
"id": "C0028127",
"name": "nitrendipine",
"pos": [
126,
138
]
} |
no significant alterations were observed in postprandial blood glucose , glycosylated haemoglobin and 24-h urinary glucose excretion . | NA | {
"id": "C0005802",
"name": "in",
"pos": [
41,
43
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
115,
122
]
} |
as measured by esterification of [ 14c ] oleate to cholesterol , it was shown that the cholesterol liberated from the degradation of both beta-vldl and ac-ldl stimulated cholesteryl ester synthesis in pigeon monocyte macrophages . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
51,
62
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
170,
187
]
} |
the main gag component of the normal cerebral arteries was heparan sulfates ( hs ) , comprising half the total gags , followed by dermatan sulfate ( ds ) and chondroitin 6-sulfate ( ch-6s ) constituting 1/5 to 1/9 the total gags . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
9,
12
]
} | {
"id": "C0019143",
"name": "heparan sulfates",
"pos": [
59,
75
]
} |
the reactivity towards the modified proteins was shown to be independent of the carrier protein as antibodies were reactive with modified human plasma proteins and modified bovine haemoglobin . | NA | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
80,
95
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
151,
159
]
} |
the parameters analysed were : superoxide dismutase , a protector against free radicals injury , enolase isoenzymes as markers of nerve cell maturation , glutamine synthetase involved in ammonia detoxification , alcohol and aldehyde deshydrogenases in order to evaluate the contribution of acetaldehyde teratogenicity and atpase activities involved in ion and neurotransmitter transport . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
224,
232
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
290,
302
]
} |
[ the maxillo-mandibular desmoid fibroma . synthesis of knowledge about a rare entity . apropos of 3 cases ] . | NA | {
"id": "C0079218",
"name": "desmoid",
"pos": [
25,
32
]
} | {
"id": "C0016045",
"name": "synthesis",
"pos": [
43,
52
]
} |
serum potassium was 3.2 meq/l and serum catecholamines , drawn approximately 20 minutes after the epinephrine administration , were 10 times normal ( dopamine , 173 ng/l ; epinephrine , 1,628 ng/l ; norepinephrine , 1,972 ng/l ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
98,
109
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
199,
213
]
} |
[ use of uv rays for the disinfection of water . iii . uv sensitivity of legionella pneumophila of different ages in cold and warm drinking water ] . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
41,
46
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
131,
145
]
} |
reductions of 99,9999 % were obtained by 16 mws/cm2 in cold drinking water ( 13-16 degrees c ) and by 13 mws/cm2 in warm drinking water ( 45-47 degrees c ) . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
69,
74
]
} | {
"id": "C0599638",
"name": "drinking water",
"pos": [
121,
135
]
} |
they are believed to enhance intestinal absorption of calcium by their ability to form soluble complexes with calcium thereby inhibiting the precipitation of phosphate-calcium salts . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
54,
61
]
} | {
"id": "C0006711",
"name": "phosphate-calcium",
"pos": [
158,
175
]
} |
these peptides bind calcium , and the cpp -- calcium complex which was not efficiently absorbed remained on the mucosal side of the tissue . | NA | {
"id": "C0030956",
"name": "peptides",
"pos": [
6,
14
]
} | {
"id": "C0031684",
"name": "cpp",
"pos": [
38,
41
]
} |
in these conditions , the physiological role of cpp on intestinal calcium absorption could be only an indirect luminal inhibition of the precipitation of phosphate-calcium salts . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
66,
73
]
} | {
"id": "C0006711",
"name": "phosphate-calcium",
"pos": [
154,
171
]
} |
only nafcillin , a penicillin , caused a decrease ( 33 per cent ) in phagocytic capacity of the neutrophils at a physiologically significant dose ( serum level ) ; | NA | {
"id": "C0027324",
"name": "nafcillin",
"pos": [
5,
14
]
} | {
"id": "C0030842",
"name": "penicillin",
"pos": [
19,
29
]
} |
the blood of the adult blackbird contains one major hemoglobin component ( hba = alpha a2 , beta 2 , ca . 80 % ) and one minor one ( hbd = alpha d2 beta 2 , ca . 20 % ) . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
52,
62
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
75,
78
]
} |
the present report demonstrates that a compound immunologically related to uti is released by digestion with porcine pancreatic elastase or human leucocyte elastase . | NA | {
"id": "C0030306",
"name": "pancreatic elastase",
"pos": [
117,
136
]
} | {
"id": "C0064833",
"name": "human",
"pos": [
140,
145
]
} |
ehrlich cells grown in the presence of high concentrations of creatine accumulate creatine phosphate to high levels ( up to 23 nmol/10 ( 6 ) cells in the presence of 40mm creatine ) . | NA | {
"id": "C0031634",
"name": "creatine phosphate",
"pos": [
82,
100
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
171,
179
]
} |
by growth of ehrlich cells in creatine-free medium it is possible to obtain `` '' creatine phosphate-depleted '' '' cells ( creatine phosphate less than 10 % of controls ) . | NA | {
"id": "C0010286",
"name": "creatine",
"pos": [
30,
38
]
} | {
"id": "C0031634",
"name": "( creatine phospha",
"pos": [
122,
140
]
} |
the immobilized enzyme showed no significant change in specific activity when spermidine was the substrate , while the enzyme affinity toward benzylamine and propylamine increased significantly . | NA | {
"id": "C0014444",
"name": "immobilized",
"pos": [
4,
15
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
119,
125
]
} |
after two weeks on the diets , mean arterial pressure ( map ) and heart rate ( hr ) were measured and blood for ne and epinephrine ( e ) assay was collected from intra-arterial cannulas in conscious , unrestrained rats . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
112,
114
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
119,
130
]
} |
basal renal renin secretion in vitro in rat kidney slices was studied in the presence of salmon calcitonin ( sct , 4400 u/mg ) , amino acid substituted analogues of sct , 16-alanine sct ( 6200 u/mg ) and 12,16,19 tri-alanine sct ( 350 u/mg ) , and of rat calcitonin gene-related peptide ( rcgrp ) . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
129,
139
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
217,
224
]
} |
it has recently been shown that imidazoline alpha 2-adrenergic agonists , such as clonidine and uk 14,304 , selectively bind to both alpha 2- and imidazoline receptors in basolateral membranes from rabbit renal proximal tubule . | NA | {
"id": "C1449836",
"name": "imidazoline",
"pos": [
32,
43
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
82,
91
]
} |
prosopagnosia and agnosic alexia represent two distinct defects of configural processing : alexics can not identify items with distinctive features that are themselves identifiable . | NA | {
"id": "C0234512",
"name": "prosopagnosia",
"pos": [
0,
13
]
} | {
"id": "C0001816",
"name": "agnosic",
"pos": [
18,
25
]
} |
these data indicated that male rem/lh subjects recognized more acquisition sentences than the other eye movement/gender groups . | NA | {
"id": "C0086582",
"name": "male",
"pos": [
26,
30
]
} | {
"id": "C0079399",
"name": "gender",
"pos": [
113,
119
]
} |
thirty-one brain tumor cases were investigated 12 non glial tumors ( 9 meningiomas and 3 metastatic tumors ) and 19 gliomas ( these were classified in 5 astrocytomas , 7 anaplastic astrocytomas and 7 glioblastomas , according to the malignancy ) . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
153,
165
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
200,
213
]
} |
the presence of laminin in 13 glioblastomas , 15 anaplastic astrocytomas , 7 astrocytomas , and 6 pilocytic astrocytomas was examined by peroxidase-antiperoxidase ( pap ) staining of formalin-fixed and paraffin-embedded surgical specimens . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
30,
43
]
} | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
108,
120
]
} |
in addition , there was a marked variety of morphological change in the basement membrane in different areas of glioblastomas , although the changes were almost constant in other astrocytic tumors . | NA | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
112,
125
]
} | {
"id": "C0004114",
"name": "astrocytic tumors",
"pos": [
179,
196
]
} |
group 1 ( n = 35 ) received analgesia only and group 2 ( n = 33 ) received thrombolytic treatment either by the intracoronary ( streptokinase , n = 13 ) or intravenous route ( anistreplase , n = 20 ) . | NA | {
"id": "C0038418",
"name": "streptokinase",
"pos": [
128,
141
]
} | {
"id": "C0078956",
"name": "anistreplase",
"pos": [
176,
188
]
} |
the patients studied had a wide range of congenital heart defects with 19 patients having isolated multiple ventricular septal defects , three with associated tetralogy of fallot , five with double outlet right ventricle , three with complete transposition and ventricular septal defect , and one with a complete atrioventricular septal defect . | NA | {
"id": "C0018798",
"name": "congenital heart defects",
"pos": [
41,
65
]
} | {
"id": "C0039685",
"name": "tetralogy of",
"pos": [
159,
171
]
} |
this may represent a pharmacogenetic abnormality or a temporary failure of midazolam metabolism secondary to the patients illness affecting the extra-hepatic sites of metabolism . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
85,
95
]
} | {
"id": "C1373176",
"name": "sites",
"pos": [
158,
163
]
} |
five healthy volunteers received , in a randomised crossover design study , a 155 mg oral tablet and an intravenous infusion of 155 mg racemic hydroxychloroquine ( 200 mg hydroxychloroquine sulphate ) to assess the bioavailability of the commercially available tablet ( plaquenil , winthrop laboratories , australia ) . | NA | {
"id": "C0993159",
"name": "oral tablet",
"pos": [
85,
96
]
} | {
"id": "C0039225",
"name": "tablet",
"pos": [
261,
267
]
} |
fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific effects on the cytochrome p-450 enzymes involved in fungal sterol synthesis . | NA | {
"id": "C0016277",
"name": "fluconazole",
"pos": [
0,
11
]
} | {
"id": "C0040880",
"name": "triazole",
"pos": [
51,
59
]
} |
patients were severely affected by epilepsy with a median monthly seizure frequency of 15.7 despite taking an average of 2.2 antiepileptic drugs . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
35,
43
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
66,
73
]
} |
studies of the influence of clinically relevant concentrations of vigabatrin on gaba-transaminase and on the release of endogenous gaba were performed in selectively cultured astrocytes and neurons . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
66,
76
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
131,
135
]
} |
at a concentration of 25 microm , vigabatrin caused a significant increase in the release of endogenous gaba from cultured gabaergic neurons . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
34,
44
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
123,
127
]
} |
although no data on brain levels of the drugs are currently available , judging from vigabatrin blood concentrations in man and from information of brain levels in animals , following chronic treatment , it is conceivable that a sufficiently high concentration of the drug in human brain is obtained to augment gaba release . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
85,
95
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
311,
315
]
} |
at therapeutic doses in man vigabatrin produces dose-related increases in csf concentrations of free and total gaba , homocarnosine ( the gaba-histidine dipeptide ) and beta-alanine . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
28,
38
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
138,
142
]
} |
impaired gabaergic function appears to contribute to seizure susceptibility in a variety of genetically-determined syndromes in animals , e.g . genetically epilepsy prone rats showing sound-induced seizures , gerbils with genetically determined epilepsy , and baboons , papio papio , with photosensitive epilepsy . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
198,
206
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
304,
312
]
} |
the aim of this study was to evaluate the effect of high concentrations of vigabatrin ( gamma-vinyl gaba ) and of gaba on myelin of the central nervous system cultures . | NA | {
"id": "C0048044",
"name": "gamma-vinyl gaba",
"pos": [
88,
104
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
114,
118
]
} |
they were exposed for up to 14 days to 500 nmol ml-1 vigabatrin or to 1000 nmol ml-1 gaba . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
53,
63
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
85,
89
]
} |
no clear-cut differences could be demonstrated between the two compounds , although vigabatrin seemed slightly more toxic than gaba at these doses . | NA | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
84,
94
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
127,
131
]
} |
lumbar punctures were carried out prior to treatment and at the end of each dosage regimen and cerebrospinal fluid ( csf ) evaluated for concentrations of free and total gaba , homocarnosine ( gaba-histidine dipeptide ) , homovanillic acid ( hva ) , 5-hydroxyindole acetic acid ( 5-hiaa ) and vigabatrin . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
170,
174
]
} | {
"id": "C0048044",
"name": "vigabatrin",
"pos": [
293,
303
]
} |
the primary tumours included 21 adenocarcinomas , nine large-cell carcinomas , 13 epidermoid carcinomas , one carcinoid and three metastases of primaries outside the lung . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
32,
47
]
} | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
110,
119
]
} |
we have been unable to confirm such a significant elevation in children with atopic dermatitis , and we have not found any correlation with dermatitis severity , age or total serum ige . | NA | {
"id": "C0011615",
"name": "atopic dermatitis",
"pos": [
77,
94
]
} | {
"id": "C0011603",
"name": "dermatitis",
"pos": [
140,
150
]
} |
the neuropeptides , cgrp and substance p , may be responsible for the intense itching of prurigo nodularis lesions . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
4,
17
]
} | {
"id": "C0006669",
"name": "cgrp",
"pos": [
20,
24
]
} |
using a sensitive , competitive enzyme-linked immunoassay ( elisa ) we were able to characterize the causative antibodies in 13 patients with drug-related agranulocytosis [ metamizole ( n = 5 ) , penicillin ( n = 5 ) , dimethylaminophenazone ( n = 1 ) , propyphenazone ( n = 1 ) and diclofenac ( n = 1 ) ] . | NA | {
"id": "C0012586",
"name": "metamizole",
"pos": [
173,
183
]
} | {
"id": "C0002586",
"name": "dimethylaminophenazone",
"pos": [
219,
241
]
} |
four monoclonal antibodies specific for lambda chain determinants reacted with 5-29 % of lambda expressing clls but the significance of this is uncertain as the antibodies may be recognizing one of the commoner v lambda subgroups . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
5,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
161,
171
]
} |
one of these antibodies detects an idiotope which was expressed significantly more frequently by cll associated immunoglobulin than by a panel of paraproteins . | NA | {
"id": "C0021027",
"name": "immunoglobulin",
"pos": [
112,
126
]
} | {
"id": "C0030490",
"name": "paraproteins",
"pos": [
146,
158
]
} |
treatment of cmk cells with phorbol ester 12-o-tetradecanoylphorbol-13-acetate ( tpa ) greatly enhanced the reactivity with anti-platelet antibodies , increased the number of cells in which cytoplasm was dissociated into numerous segments and suppressed the reactivity with anti-glycophorin a . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
28,
41
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
42,
78
]
} |
on clinical grounds it is usually easy to distinguish between preseptal cellulitis , a cutaneous infection not threatening to vision , and orbital cellulitis , a potentially vision threatening infection of the orbital tissues generally arising from paranasal sinusitis . | NA | {
"id": "C0037278",
"name": "cutaneous infection",
"pos": [
87,
106
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
193,
202
]
} |
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