text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
all label and antibody combinations were examined , and the most sensitive and specific combination ( antiserum raised against androstenedione-3-carboxymethyloxime-bovine serum albumin with an androstenedione-carboxymethyloxime- [ 125i ] iodohistamine label ) was selected for full evaluation . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
14,
22
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
102,
111
]
} |
this isoenzyme decayed with approximate first-order kinetics , with an estimated half-life at -20 degrees c of about 475 years . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
52,
60
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
81,
90
]
} |
quantification of choriogonadotropin : differential cross-reactivities of the free hcg beta-subunit with eight different monoclonal antibody-based hcg and ( hcg + beta ) `` '' sandwich '' '' -type assays . | NA | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
18,
36
]
} | {
"id": "C0106132",
"name": "hcg",
"pos": [
157,
160
]
} |
we describe a case of choriocarcinoma in which increased concentrations of beta-choriogonadotropin subunits in serum indicated recurrence of metastasis long before the tumor could be confirmed by visualization techniques , while intact choriogonadotropin remained normal ( less than 5 int . units/l ) . | NA | {
"id": "C0106132",
"name": "beta-choriogonadotropin subunits",
"pos": [
75,
107
]
} | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
236,
254
]
} |
therefore , detection or monitoring of choriocarcinoma requires the assay of free beta-hcg subunit or an assay that measures both the free beta-subunit and intact choriogonadotropin . | NA | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
82,
90
]
} | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
163,
181
]
} |
fibronectin levels were serially assayed during the third trimester of pregnancy and puerperium in a group women with uncomplicated pregnancies , and two groups with mild/severe hypertensive disorders of pregnancy . | NA | {
"id": "C0032981",
"name": "third trimester",
"pos": [
52,
67
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
132,
143
]
} |
in order to develop a better formula for discrimination between transsudated and intrathecally produced igg , we studied the relation between cerebrospinal fluid ( csf ) igg , serum igg , csf albumin , and serum albumin for patients with blood brain barrier ( bbb ) damage . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
192,
199
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
206,
219
]
} |
the association between apoe4 and serum total and ldl cholesterol level may be mediated through the ldl ( apob100 , apoe ) receptor to a greater extent than previously thought . | NA | {
"id": "C0052201",
"name": "apoe4",
"pos": [
24,
29
]
} | {
"id": "C0003595",
"name": "apoe",
"pos": [
116,
120
]
} |
the alpha subunit precursor synthesized by patients ' cells could not be phosphorylated , nor was the patients ' alpha subunit precursor secreted into the medium in response to nh4cl , which caused accumulation of both alpha and beta subunit precursor in the medium of the normal control fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
54,
59
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
288,
299
]
} |
anti-70 kd antibodies were found in 94 % of patients with mixed connective tissue disease ( mctd ) , in 4 % of patients with other connective tissue diseases but not in normal controls . | NA | {
"id": "C0026272",
"name": "mixed connective tissue disease",
"pos": [
58,
89
]
} | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
131,
157
]
} |
sera from rheumatoid arthritis , juvenile rheumatoid arthritis , progressive systemic sclerosis , sjogren 's syndrome and undifferentiated connective tissue disease were negative . | NA | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
10,
20
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
98,
117
]
} |
in 12-h cell cultures of adherent cells , significantly increased spontaneous intracellular il-1 beta production was determined in sf macrophage ( sfm phi ) cultures of ra patients compared to pb monocyte ( pbmo ) cultures of controls ( median values : 91.0 ng/10 ( 6 ) cells vs . | NA | {
"id": "C1321301",
"name": "pb monocyte",
"pos": [
193,
204
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
270,
275
]
} |
in vivo-activated interleukin 2 receptor-positive t lymphocytes ( tac cells ) are demonstrable and the autologous mixed leukocyte reaction ( amlr ) is impaired in several autoimmune diseases , including type 1 insulin-dependent diabetes mellitus ( iddm ) . | NA | {
"id": "C0004364",
"name": "autoimmune diseases",
"pos": [
171,
190
]
} | {
"id": "C0011854",
"name": "insulin-dependent diabetes",
"pos": [
210,
236
]
} |
in solid-phase assays , the human autoimmune serum and the antigen-induced rabbit serum competed for similar or overlapping epitopes on the ro particle . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
59,
66
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
124,
132
]
} |
( vi ) thymocytes were depleted by monoclonal antibody treatment by using 1000-fold more antibody than needed to deplete peripheral lymphocytes ; | NA | {
"id": "C0003250",
"name": "monoclonal antibody",
"pos": [
35,
54
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
89,
97
]
} |
we report two caucasian families with systemic sclerosis and other connective tissue and immunological disorders , including rheumatoid arthritis , discoid lupus erythematosus , psoriasis , psoriatic arthritis , ankylosing spondylitis , ulcerative colitis , asthma , sjogren 's syndrome , raynaud 's phenomenon and thyroid disease . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
125,
145
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
267,
286
]
} |
we report two caucasian families with systemic sclerosis and other connective tissue and immunological disorders , including rheumatoid arthritis , discoid lupus erythematosus , psoriasis , psoriatic arthritis , ankylosing spondylitis , ulcerative colitis , asthma , sjogren 's syndrome , raynaud 's phenomenon and thyroid disease . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
178,
187
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
190,
209
]
} |
we have evaluated pl and sf concentrations of ln ( in particular la , nd , ce , yb , lu , eu ) , in rheumatoid arthritis patients , before and after intra-articular steroid injection . | NA | {
"id": "C0205838",
"name": "ln",
"pos": [
46,
48
]
} | {
"id": "C0023031",
"name": "la",
"pos": [
161,
163
]
} |
in response to osteoarthritic metabolic lesions the binding pattern of wga revealed an increased cellular staining throughout the whole depth of the tissue which represents the compensatory activity of chondrocytes . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
97,
105
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
202,
214
]
} |
the frequency of igg and igm anti-total histones and anti-histone subfractions were studied in 63 patients with sle and 257 patients with other autoimmune conditions employing the elisa . | NA | {
"id": "C0024141",
"name": "sle",
"pos": [
112,
115
]
} | {
"id": "C0004364",
"name": "autoimmune",
"pos": [
144,
154
]
} |
she was also found to be suffering from chronic thyroiditis ( hypothyroidism ) and was positive for anti-thyroid hormone antibodies , which have not been reported before in the sle patients with thyroid diseases . | NA | {
"id": "C0020676",
"name": "hypothyroidism",
"pos": [
62,
76
]
} | {
"id": "C0040128",
"name": "thyroid diseases",
"pos": [
195,
211
]
} |
the lead found in drinking water can be a source of lead poisoning to young children , particularly those who consume large amounts of water . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
18,
32
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
135,
140
]
} |
a statistically significant increase in the value of glycosylated hb was found in sickle cell trait ( hbas ) group , when compared with those of sickle cell anemia ( hbss ) and normal ( hbaa ) groups . | NA | {
"id": "C0037054",
"name": "sickle cell trait",
"pos": [
82,
99
]
} | {
"id": "C0002895",
"name": "sickle cell anemia",
"pos": [
145,
163
]
} |
since glycosylated hb is considered a valid indicator of long-term blood glucose , and assuming normal red blood cell survival in hbas carriers , the increased value of glycosylated hb may suggest that there exists a higher incidence of undiagnosed diabetes mellitus in individuals with heterozygous inheritance for sickle cell hemoglobin than homozygous sickle cell patients and normal individuals . | NA | {
"id": "C0019016",
"name": "hbas",
"pos": [
130,
134
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
328,
338
]
} |
fibroblast cultures exposed to the drugs inducing a collagen-like syndrome ( hydralazine and binazine ) displayed growth inhibition and decrease in cellular protein content in a dose-dependent manner compared with control cultures . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
0,
10
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
148,
156
]
} |
in three of these patients , in whom there was ct evidence of bilateral mass lesions of the brain , this epileptic activity became generalised into grand mal seizures , and two died in status epilepticus . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
105,
114
]
} | {
"id": "C0038220",
"name": "status epilepticus",
"pos": [
185,
203
]
} |
body nitrogen balance , leg and forearm plasma amino acid flux and whole-body kinetics were measured before and on day 10 of ivf using a [ 1-13c ] leucine and [ 15n ] glycine tracer . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
47,
57
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
167,
174
]
} |
groups of animals were injected with either endotoxin ( lps ; escherichia coli lipopolysaccharide 0.127 b8 ; 3 mg/kg body weight ) or saline . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
44,
53
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
79,
97
]
} |
the effects of non-lethal bacteraemia or endotoxaemia on insulin-stimulated glucose metabolism were studied in isolated , incubated soleus muscle of rats after 24 and 48 h . | NA | {
"id": "C0004610",
"name": "bacteraemia",
"pos": [
26,
37
]
} | {
"id": "C0376618",
"name": "endotoxaemia",
"pos": [
41,
53
]
} |
labelled diphosphonates , and in particular 99technetium-methylene-diphosphonate ( 99tcmdp ) are simpler and safer , because these substances are strongly and almost completely stored in bone and not absorbed by the soft tissue ; | NA | {
"id": "C0012544",
"name": "diphosphonates",
"pos": [
9,
23
]
} | {
"id": "C0066351",
"name": "methylene-diphosphonate",
"pos": [
57,
80
]
} |
the evaluation of blood levels and 24 hrs urinary elimination of 99tcmdp is used to measure whole bone diphosphonate retention ( wbr ) . | NA | {
"id": "C0066351",
"name": "99tcmdp",
"pos": [
65,
72
]
} | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
103,
116
]
} |
a good example is provided in corticosteroid osteoporosis which is characterised by thinning of trabecular elements , whereas postmenopausal osteoporosis is characterised less by thinning and more by destruction of trabecular elements which derange trabecular continuity . | NA | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
45,
57
]
} | {
"id": "C0029458",
"name": "postmenopausal osteoporosis",
"pos": [
126,
153
]
} |
since most treatments for osteoporosis affect bone remodelling they are likely to have a greater effect in restoring structural integrity of the skeleton in corticosteroid than in postmenopausal osteoporosis . | NA | {
"id": "C0029456",
"name": "osteoporosis",
"pos": [
26,
38
]
} | {
"id": "C0029458",
"name": "postmenopausal osteoporosis",
"pos": [
180,
207
]
} |
fifty patients with liver disease , of whom twenty-four had chronic active hepatitis and twenty-three had liver cirrhosis , were studied and compared with thirty-nine age- and sex-matched controls . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
20,
33
]
} | {
"id": "C0023890",
"name": "liver cirrhosis",
"pos": [
106,
121
]
} |
one hundred and forty-two children , of whom 56 had participated in a fluoride tablet program of 0.5/1.0 mg naf per day were examined blindly for possible fluoride-induced enamel changes . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
108,
111
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
155,
163
]
} |
ninety-nine inpatients , who met the dms-iii-r criteria for major depression , dysthymic disorder , or depressive disorder not otherwise specified ( nos ) , took part in the study . | NA | {
"id": "C0013415",
"name": "dysthymic disorder",
"pos": [
79,
97
]
} | {
"id": "C0011581",
"name": "depressive disorder",
"pos": [
103,
122
]
} |
the synthesis of cellular and nuclear basic proteins in the first generation of the repopulated pachytene spermatocyte ( rps ) and the control pachytene spermatocyte ( cps ) was studied by the incorporation of 3h-arginine into proteins . | NA | {
"id": "C0028589",
"name": "nuclear",
"pos": [
30,
37
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
227,
235
]
} |
furthermore , the putative role of this protein has a multifunctional connecting link of the cytomatrix and its structural as well as functional relationship to other cytoskeletal proteins is discussed . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
167,
188
]
} |
study on the relationship between pharmacokinetics and antibacterial activity : comparison between ceftriaxone and cefotaxime within the respiratory tract . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
99,
110
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
115,
125
]
} |
the aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
86,
97
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
102,
112
]
} |
in this study , a dna sequence polymorphism , revealed by digestion of human dna with the restriction endonuclease sst1 and hybridization with an apoprotein ai cdna probe , has been shown to be located at apoai/ciii gene-loci . | NA | {
"id": "C0000702",
"name": "a dna",
"pos": [
16,
21
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
161,
164
]
} |
homoharringtonine , a chemotherapeutic drug used in the so-called hoap regimen for acute nonlymphocytic leukemia , seems to possess the capability of inducing hl-60 , the promyelocytic leukemia cell line , to nbt positive myeloid terminal cells , although the inducing effect is weaker than retinoic acid . | NA | {
"id": "C0023467",
"name": "acute nonlymphocytic leukemia",
"pos": [
83,
112
]
} | {
"id": "C0023487",
"name": "promyelocytic leukemia",
"pos": [
171,
193
]
} |
3 ) even after the intra-articular fractures were well-healed , degeneration and hyperplasia of the articular chondrocytes nearby the fracture would persist for some time . | NA | {
"id": "C0332715",
"name": "intra-articular fractures",
"pos": [
19,
44
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
134,
142
]
} |
in this group , 26 cases ( 21 % ) had conal septal defects , one ( 1 % ) had a muscular vsd and 94 ( 78 % ) membranous vsd . | NA | {
"id": "C0018816",
"name": "septal defects",
"pos": [
44,
58
]
} | {
"id": "C0018818",
"name": "vsd",
"pos": [
119,
122
]
} |
data on menstrual pattern , gynecological disorders and infertility were obtained from 51 chronic alcoholic women aged 20 -- 42 years attending an outpatient clinic for alcoholics , using 51 randomly drawn age-matched healthy women as controls . | NA | {
"id": "C0017411",
"name": "gynecological disorders",
"pos": [
28,
51
]
} | {
"id": "C0021359",
"name": "infertility",
"pos": [
56,
67
]
} |
the increase of magnesium concentration in serum achieved by means of magnesium gluconate turned out to be higher than the increase of concentration due to the administration of magnesium chloride . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
16,
25
]
} | {
"id": "C0126777",
"name": "magnesium gluconate",
"pos": [
70,
89
]
} |
the increase of magnesium concentration in serum achieved by means of magnesium gluconate turned out to be higher than the increase of concentration due to the administration of magnesium chloride . | NA | {
"id": "C0024467",
"name": "magnesium",
"pos": [
16,
25
]
} | {
"id": "C0024472",
"name": "magnesium chloride",
"pos": [
178,
196
]
} |
regarding the reduction of stress in rats , the optimal concentration in feed is between 500 and 1000 mg of magnesium as magnesium gluconate per kg . | NA | {
"id": "C0024467",
"name": "mg",
"pos": [
102,
104
]
} | {
"id": "C0126777",
"name": "magnesium",
"pos": [
121,
130
]
} |
extending our analysis to partial and nonsymmetrical cross-reactivities , these epitopes were shown to be localized in 4 antigenic domains of the htpo . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
80,
88
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
121,
130
]
} |
we further investigated the nature of these 7 htpo epitopes by testing mab binding to peroxidases from various origins and chemically modified htpo ; | NA | {
"id": "C0031179",
"name": "peroxidases",
"pos": [
86,
97
]
} | {
"id": "C0021965",
"name": "htpo",
"pos": [
143,
147
]
} |
in vitro studies were performed to assess the ability of term human trophoblastic tissue to metabolize 25-hydroxyvitamin d3 ( 25ohd3 ) and to compare this metabolism to that occurring in porcine renal mitochondria and microsomes . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
103,
123
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
126,
132
]
} |
insulin and igf-i had effects comparable to each other , but much smaller concentrations of igf-i were required ; | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
12,
17
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
92,
95
]
} |
phosphorylation of pp195 has an absolute requirement in vitro for mn2+ or mg2+ and for certain basic poly-amino acids , i.e . poly-l-lysine or poly-l-ornithine . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
95,
100
]
} | {
"id": "C0024337",
"name": "lysine",
"pos": [
133,
139
]
} |
insulin-like growth factor-i ( igf-i ) , the principal igf in adult rat serum , occurs complexed to specific binding proteins . | NA | {
"id": "C0021665",
"name": "igf-i",
"pos": [
31,
36
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
55,
58
]
} |
serum lipoproteins were separated by sequential ultracentrifugation into very low density lipoproteins [ density ( d ) less than 1.006 g/ml ] , low density lipoproteins ( ldl ; d 1.006-1.063 g/ml ) and high density lipoproteins ( hdl ; d 1.063-1.21 g/ml ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
6,
18
]
} | {
"id": "C0023825",
"name": "very low",
"pos": [
73,
81
]
} |
this study assessed the effect of a dietary deficiency in the essential fatty acids ( efa ) linoleic and linolenic acids on the onset of female puberty . | NA | {
"id": "C0015686",
"name": "essential fatty",
"pos": [
62,
77
]
} | {
"id": "C0023752",
"name": "linolenic acids",
"pos": [
105,
120
]
} |
phorbol ester treatment ( 32-162 nm pma ) also inhibited androstenedione production in thecal cells stimulated by the presence of 8-bromo-camp ( 1 mm ) , indicating a post-camp effect of protein kinase-c activity on steroidogenesis . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
0,
13
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
36,
39
]
} |
( ii ) the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate ( tpa ) is an effective mitogen in both clonal cultures and non-clonal early cultures of human adrenocortical cells , and shows a selective action in promoting adrenocortical cell growth and inhibiting fibroblast growth ; | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
11,
24
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl phorbol 13-acetate",
"pos": [
25,
62
]
} |
the p-450 eluted from the cm-sephadex column at different points along the buffer concentration gradient , exhibited significant differences in ( 1 ) the 21-hydroxylation of 17 alpha-oh-progesterone compared to progesterone and ( 2 ) the type i spectral change produced by 17 alpha-oh-progesterone compared to that due to delta 4-androstenedione . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
186,
198
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
273,
275
]
} |
the ratio , 21-hydroxylation of 17 alpha-oh-progesterone/progesterone ranged between 2.6 and 0.86 suggesting that the purified preparation is a mixture of 17 alpha-oh-progesterone preferring and progesterone preferring species . | NA | {
"id": "C0020387",
"name": "17",
"pos": [
32,
34
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
195,
207
]
} |
pretreatment of confluent human fibroblast cultures for two days in dexamethasone , serum free medium increased 10-20 fold the sensitivity of the cells to insulin-like growth factor i ( igf i ) stimulation of amino acid uptake using the amino acid analog alpha-aminoisobutyric acid ( aib ) . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
32,
42
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
233,
236
]
} |
polychlorinated biphenyls ( pcbs ) as environmental contaminants often can not be adequately described by reference to aroclors or to total pcbs . | NA | {
"id": "C0003804",
"name": "aroclors",
"pos": [
119,
127
]
} | {
"id": "C0032447",
"name": "pcbs",
"pos": [
140,
144
]
} |
forty patients undergoing gynaecological surgery were randomly assigned to receive either alfentanil and thiopentone for induction of anaesthesia , followed by alfentanil-n2o/o2 ( 60 % /40 % ) for maintenance of anaesthesia , or low-dose fentanyl and thiopentone , followed by enflurane-n2o/o2 ( 60 % /40 % ) . | NA | {
"id": "C0002026",
"name": "alfentanil",
"pos": [
90,
100
]
} | {
"id": "C0015846",
"name": "fentanyl",
"pos": [
238,
246
]
} |
the purpose of this study was to assess the effects of a 2 h cycle exercise ( 50 % vo2max ) on heart rate ( hr ) and blood pressure ( bp ) , and on plasma epinephrine ( e ) and norepinephrine ( ne ) concentrations , during the recovery period in seven normotensive subjects . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
155,
166
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
177,
191
]
} |
in published summaries of observations shown here and in a follow-up study with chick embryo fibroblasts , the enzyme ( s ) has been referred to as mitogen-responsive s6 kinase ( s ) [ martini , o. h. w. and lawen , a . ( 1985 ) in hormones and cell regulation ( dumont , j. e. , hamprecht , b. and nunez , j. , eds ) vol . 9 , pp . 411-412 , elsevier company , north-holland , amsterdam ; lawen , a. and martini , o. h. w. ( 1985 ) febs lett . 185 , 272-276 ] . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
93,
104
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
245,
249
]
} |
we have reported that spermidine n1-acetyltransferase has a larger role than ornithine decarboxylase in putrescine synthesis in chick duodenum induced by 1 alpha,25-dihydroxycholecalciferol ( calcitriol ) [ shinki , t. , kadofuku , t. , sato , t. and suda , t. ( 1986 ) j. biol . chem . 261 , 11712-11716 ] . | NA | {
"id": "C0012328",
"name": "dihydroxycholecalciferol",
"pos": [
165,
189
]
} | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
192,
202
]
} |
during the influx experiments , no conversion of [ 3h ] cholesterol to [ 3h ] cholesteryl ester was observed either in the cell layer or in the incubation medium . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
56,
67
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
78,
95
]
} |
on the other hand , during efflux experiments when hdl but not human serum was the acceptor , some ( about 6 % ) conversion of [ 3h ] cholesterol to [ 3h ] cholesteryl ester occurred in the incubation medium . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
134,
145
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
156,
173
]
} |
the phorbol ester 12-o-tetradecanoyl-phorbol 13-acetate ( tpa ) and thyroliberin exerted additive stimulatory effects on prolactin release and synthesis in rat adenoma gh4c1 pituicytes in culture . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
4,
17
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol 13-acetate",
"pos": [
18,
55
]
} |
two monoclonal antibodies specific for smooth muscle myosin ( designated sm-e7 and sm-a9 ) and one monoclonal anti- ( human platelet myosin ) antibody ( designated nm-g2 ) have been used to study myosin heavy chain composition of smooth muscle cells in adult and in developing rabbit aorta . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
4,
25
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
142,
150
]
} |
the structural and kinetic properties of the enzyme were compared with those of the other alkaline phosphatase isozymes expressed in normal human tissues , i.e . the placental , intestinal , meconial ( fetal ) , liver and kidney isozymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
45,
51
]
} | {
"id": "C0022173",
"name": "isozymes",
"pos": [
229,
237
]
} |
it was found that b. fragilis lipid a consists of a beta-d-glucosaminyl- ( 1-6 ) -d-glucosaminyl-1-o-phosphate backbone whose hydroxyl groups in positions 4 , 4 ' and 6 ' are free , the latter serving as the attachment site for the polysaccharide component in lipopolysaccharide . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
30,
37
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
260,
278
]
} |
short-term pure cultures and long-term cocultures of adult rat hepatocytes with rat liver epithelial cells , presumably derived from primitive biliary cells , were used to define in vitro models of iron overloaded hepatocytes in order to understand the molecular mechanism responsible for liver damage occurring in patients with hemochromatosis . | NA | {
"id": "C0282193",
"name": "iron overloaded",
"pos": [
198,
213
]
} | {
"id": "C0018995",
"name": "hemochromatosis",
"pos": [
329,
344
]
} |
the use in parallel of in situ hybridization with specific staining for dna and autoradiography after tritiated thymidine incorporation , followed by either conventional fixation of the cells or the nucleoprotein loosening procedure , indicated that non-encapsidated viral dna and marginated host chromatin formed two juxtaposed compartments without interpenetration even after experimentally produced mild dispersion of the nuclear components . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
72,
75
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
267,
276
]
} |
the use in parallel of in situ hybridization with specific staining for dna and autoradiography after tritiated thymidine incorporation , followed by either conventional fixation of the cells or the nucleoprotein loosening procedure , indicated that non-encapsidated viral dna and marginated host chromatin formed two juxtaposed compartments without interpenetration even after experimentally produced mild dispersion of the nuclear components . | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
199,
212
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
297,
306
]
} |
the metabolism and kinetics of unmodified human igg ( 125i-c-425 ) was studied in rats and rabbits after intravenous injection with regard to changes as a function of time of radioactivity in the blood and other tissues , excretion into the bile and placental permeability . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
222,
231
]
} |
however , in the case of i-278 , the enhancement resulted from micromolar concentrations of 2-nitroimidazole as opposed to the millimolar quantities required for a similar enhancement by miso . | NA | {
"id": "C0028179",
"name": "nitroimidazole",
"pos": [
94,
108
]
} | {
"id": "C0026218",
"name": "miso",
"pos": [
187,
191
]
} |
in total cell extracts , at least ten proteins were induced de novo , or increased in their expression , after an 18-h ifn-gamma treatment , whereas in the nuclear extracts eight proteins were specifically induced . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
38,
46
]
} | {
"id": "C0028589",
"name": "nuclear",
"pos": [
156,
163
]
} |
the maf-inhibiting function of tssn appears to be mediated by interleukin ( il ) 3 and il4 , since the maf activity of trsn and rifn-gamma also can be inhibited by the addition of ril3 and ril4 but not by ril1 or ril2 . | NA | {
"id": "C0021764",
"name": "interleukin",
"pos": [
62,
73
]
} | {
"id": "C0021758",
"name": "il4",
"pos": [
190,
193
]
} |
therefore , we can conclude that both subsets of tcr gamma/delta+ cells are able to specifically recognize and lyse allogeneic cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
66,
71
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
116,
132
]
} |
the results showed that three peptides carried epitopes to which mice responded following injection of the whole molecule and that immunization with two additional peptides could prime for in vitro stimulation with the native antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
47,
55
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
226,
233
]
} |
il 4 inhibited the generation of il 1 activity and that of il 1 alpha and il 1 beta antigens indicating that il 4 interfered with il 1 transcription and/or processing rather than induced the synthesis of an il 1 inhibitor . | NA | {
"id": "C0600251",
"name": "il 1 alpha",
"pos": [
59,
69
]
} | {
"id": "C0021755",
"name": "il 1",
"pos": [
207,
211
]
} |
all four adenosine receptor agonists , r-phenylisopropyladenosine ( r-pia ) , s-phenylisopropyladenosine ( s-pia ) , n-ethylcarboxamide adenosine ( neca ) , and 2-chloroadenosine ( cado ) significantly decreased gastric acid output in a dose-dependent manner . | NA | {
"id": "C0031484",
"name": "phenylisopropyladenosine",
"pos": [
41,
65
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
169,
178
]
} |
all four adenosine receptor agonists , r-phenylisopropyladenosine ( r-pia ) , s-phenylisopropyladenosine ( s-pia ) , n-ethylcarboxamide adenosine ( neca ) , and 2-chloroadenosine ( cado ) significantly decreased gastric acid output in a dose-dependent manner . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
9,
18
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
161,
178
]
} |
neca decreased the volume of gastric secretion , whereas r-pia had no effect on volume , but significantly increased the ph of the secretions . | NA | {
"id": "C0001443",
"name": "neca",
"pos": [
0,
4
]
} | {
"id": "C0031484",
"name": "r-pia",
"pos": [
57,
62
]
} |
such an effect was only detected in the presence of ada so that endogenous adenosine can obviously mask small effects of pia on adenylate cyclase activity or the cyclic amp content . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
75,
84
]
} | {
"id": "C0031484",
"name": "pia",
"pos": [
121,
124
]
} |
the effect of apomorphine was not antagonized by 10 or 20 mg/kg l-norfenfluramine , an active metabolite of l-fenfluramine but 20 mg/kg l-norfenfluramine significantly raised striatal 3-methoxytyramine levels . l-fenfluramine 20 mg/kg ( but not 10 mg/kg ) significantly enhanced the output of striatal acetylcholine assessed by trans-striatal microdialysis , for 60 min after injection . | NA | {
"id": "C0028362",
"name": "norfenfluramine",
"pos": [
66,
81
]
} | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
213,
225
]
} |
the results suggest that , in addition to the neutral form , highly lipophilic amine local anesthetics may penetrate into and/or pass across the neuronal membrane probably as electroneutral ion pair complexes consisting of the cationic form and an appropriate anion . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
35,
38
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
227,
235
]
} |
the results suggest that , in addition to the neutral form , highly lipophilic amine local anesthetics may penetrate into and/or pass across the neuronal membrane probably as electroneutral ion pair complexes consisting of the cationic form and an appropriate anion . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
35,
38
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
260,
265
]
} |
bn 52021 caused a dose-related protection against dysrhythmias , such as ventricular fibrillation , ventricular tachycardia , and premature ventricular beats induced by ischemia ( 30 min ligation of the left anterior descending coronary artery ) . | NA | {
"id": "C0003811",
"name": "dysrhythmias",
"pos": [
50,
62
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
73,
97
]
} |
in a concentration ( 30 microm ) virtually devoid of an effect on the e.p.p.s , twitch responses , or resting membrane potential of the muscle fibres , diazepam potentiated the inhibitory action of adenosine on neuromuscular transmission , but not that induced by the stable analogue of adenosine 5'-n-ethylcarboxamide adenosine ( neca ) , which is not a substrate for the adenosine uptake system . | NA | {
"id": "C0050789",
"name": "adenosine",
"pos": [
198,
207
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
373,
382
]
} |
anions like nitrate , azide , thiocyanate and cyanate that shift the spectrum toward the blue do not affect this 70 % exchange . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
0,
6
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
12,
19
]
} |
the increased binding of radiolabeled guanine nucleotide upon illumination of ros in the presence of atp was confirmed , but the species of guanine nucleotide that were stimulated to bind under these conditions were identified as [ 32p ] gdp and [ 32p ] gtp rather than [ 32p ] cgmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
38,
56
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
238,
241
]
} |
the increased binding of radiolabeled guanine nucleotide upon illumination of ros in the presence of atp was confirmed , but the species of guanine nucleotide that were stimulated to bind under these conditions were identified as [ 32p ] gdp and [ 32p ] gtp rather than [ 32p ] cgmp . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
38,
56
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
254,
257
]
} |
although several ros proteins can form filter-retainable complexes with gdp and gtp , the properties of the 58 kda protein found to be photoaffinity labeled with radioactive guanine nucleotide are most characteristic of those attributable to tubulin . | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
72,
75
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
174,
192
]
} |
although several ros proteins can form filter-retainable complexes with gdp and gtp , the properties of the 58 kda protein found to be photoaffinity labeled with radioactive guanine nucleotide are most characteristic of those attributable to tubulin . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
80,
83
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
174,
192
]
} |
testing the sections with a library of polyclonal and monoclonal antibodies resulted in the definition of the following immunohistochemical phenotype of rcc : positive with the ld-m1 , ld-m2 , ld-m5 , ld-m8 , uro-2 , uro-7 , uro-10 , cytokeratin , keratin , tpa , vimentin , fx1a , retinol binding protein , calla and b72 antibodies ; | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
54,
75
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
322,
332
]
} |
the pattern of immunohistochemical activity indicates that some rcc tumor cells contain epitopes associated with distal tubules in addition to previously documented antigens present in proximal tubules . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
88,
96
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
165,
173
]
} |
in order to assess the role of the bronchial circulation in the pathogenesis of exercise-induced asthma ( eia ) , we conducted a double-blind , randomized study of the effects of pretreatment with an inhaled alpha 1-adrenergic agonist , methoxamine ( mx ) , in nine asthmatic teenagers with known eia . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
266,
275
]
} | {
"id": "C0004099",
"name": "eia",
"pos": [
297,
300
]
} |
the data demonstrate that human semen contains the trh-like peptide pyroglutamylglutamylprolinamide and also a polypeptide terminating in the sequence gln-glu-pronh2 . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
151,
154
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
155,
158
]
} |
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