query
string
positive
list
negative
list
system
string
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'Epitope-tagged DCX transiently expressed in COS cells can be co-immunoprecipitated with endogenous LIS1.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'Furthermore, endogenous DCX could be co-immunoprecipitated with endogenous LIS1 in embryonic brain extracts, demonstrating an in vivo association.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'In addition, we demonstrate homodimerization of DCX in vitro.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'Using fragments of both LIS1 and DCX, the domains of interaction were mapped.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'LIS1 and DCX interact with tubulin and microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'LIS1 and DCX interact with tubulin and microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'Our results suggest that addition of DCX and LIS1 to tubulin enhances polymerization in an additive fashion.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'In in vitro competition assays, when LIS1 is added first, DCX competes with LIS1 in its binding to microtubules, but when DCX is added prior to the addition of LIS1 it enhances the binding of LIS1 to microtubules.', answer the user's query.
What is the biomedical concept corresponding to 'lis1'?
[ "lis1 (homo sapiens)" ]
[ "lissencephaly-1 homolog (caenorhabditis elegans)", "lis3 (homo sapiens)", "lis7 (homo sapiens)", "lis-1 (drosophila melanogaster)" ]
Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', answer the user's query.
What is the biomedical concept corresponding to 'dcx'?
[ "dcx (homo sapiens)", "doublecortin (homo sapiens)" ]
[ "dcxr (homo sapiens)", "dcx (rattus norvegicus)", "doublecortin (xenopus tropicalis)", "dcx (oryctolagus cuniculus)" ]
Given the context 'We conclude that LIS1 and DCX cross-talk is important to microtubule function in the developing cerebral cortex.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. Kv4.2 potassium channels play a critical role in postsynaptic excitability.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. Kv4.2 potassium channels play a critical role in postsynaptic excitability.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Immunocytochemical studies reveal a somatodendritic Kv4.2 expression pattern, with the channels concentrated mainly at dendritic spines.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'The molecular mechanism that underlies the localization of Kv4.2 to this subcellular region is unknown.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'We used the yeast two-hybrid system to identify the Kv4.2-associated proteins that are involved in channel localization.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Here we demonstrate a direct interaction between Kv4.2 and the actin-binding protein, filamin.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'We show that Kv4.2 and filamin can be coimmunoprecipitated both in vitro and in brain and that Kv4.2 and filamin share an overlapping expression pattern in the cerebellum and cultured hippocampal neurons.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'To examine the functional consequences of this interaction, we expressed Kv4.2 in filamin(+) and filamin(-) cells and performed immunocytochemical and electrophysiological analyses.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Our results indicate that Kv4.2 colocalizes with filamin at filopodial roots in filamin(+) cells but shows a nonspecific expression pattern in filamin(-) cells, with no localization to filopodial roots.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'Furthermore, the magnitude of whole-cell Kv4.2 current density is approximately 2.7-fold larger in filamin(+) cells as compared with these currents in filamin(-) cells.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', answer the user's query.
What is the biomedical concept corresponding to 'kv4.2'?
[ "kv4.2 (homo sapiens)" ]
[ "kv4.2 (mus musculus)", "kv7.4 (homo sapiens)", "kv4 (homo sapiens)", "kv6.4 (homo sapiens)" ]
Given the context 'We propose that filamin may function as a scaffold protein in the postsynaptic density, mediating a direct link between Kv4.2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities.', answer the user's query.
What is the biomedical concept corresponding to 'tmprss3'?
[ "tmprss3 (homo sapiens) (transmembrane serine protease 3 (homo sapiens))", "transmembrane serine protease 3 (homo sapiens)" ]
[ "tmprss3 (sus scrofa)", "tmprss3 (mus musculus)", "tmprss3 (bos taurus)", "tmprss3 (homo sapiens) (transmembrane serine protease 4 (homo sapiens))" ]
Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', answer the user's query.
What is the biomedical concept corresponding to 'echos1'?
[ "echos1 (homo sapiens)" ]
[ "echos1 (xenopus tropicalis)", "echos1 (xenopus laevis)", "endometriosis, susceptibility to, 1 (homo sapiens)", "aes-1 (homo sapiens)" ]
Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', answer the user's query.
What is the biomedical concept corresponding to 'dfnb10'?
[ "dfnb10 (homo sapiens)" ]
[ "dfna10 (homo sapiens)", "dfnb9 (homo sapiens)", "dfnb110 (homo sapiens)", "dfnb40 (homo sapiens)" ]
Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', answer the user's query.
What is the biomedical concept corresponding to 'dfnb8'?
[ "dfnb8 (homo sapiens)", "dfnb10 (homo sapiens)" ]
[ "dfna8 (homo sapiens)", "dfn6 (homo sapiens)", "dfnb9 (homo sapiens)", "dfnb4 (homo sapiens)" ]
Given the context 'Here we report the identification of a new transmembrane serine protease (TMPRSS3; also known as ECHOS1) expressed in many tissues, including fetal cochlea, which is mutated in the families used to describe both the DFNB10 and DFNB8 loci.', answer the user's query.
What is the biomedical concept corresponding to 'dfnb10'?
[ "dfnb10 (homo sapiens)" ]
[ "dfna10 (homo sapiens)", "dfnb9 (homo sapiens)", "dfnb110 (homo sapiens)", "dfnb40 (homo sapiens)" ]
Given the context 'An 8-bp deletion and insertion of 18 monomeric (approximately 68-bp) beta-satellite repeat units, normally present in tandem arrays of up to several hundred kilobases on the short arms of acrocentric chromosomes, causes congenital deafness (DFNB10).', answer the user's query.
What is the biomedical concept corresponding to 'dfnb8'?
[ "dfnb8 (homo sapiens)", "dfnb10 (homo sapiens)" ]
[ "dfna8 (homo sapiens)", "dfn6 (homo sapiens)", "dfnb9 (homo sapiens)", "dfnb4 (homo sapiens)" ]
Given the context 'A mutation in a splice-acceptor site, resulting in a 4-bp insertion in the mRNA and a frameshift, was detected in childhood onset deafness (DFNB8).', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. ', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'Germline mutations of the human BRCA2 gene confer susceptibility to breast cancer.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'Although the function of the BRCA2 protein remains to be determined, murine cells homozygous for BRCA2 inactivation display chromosomal aberrations.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf35 (mus musculus)", "braf1 (homo sapiens)", "braf (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))" ]
Given the context 'We have isolated a 2 MDa BRCA2-containing complex and identified a structural DNA binding component, designated as BRCA2-Associated Factor 35 (BRAF35).', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf35 (mus musculus)", "braf1 (homo sapiens)", "braf (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))" ]
Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (mus musculus)" ]
[ "braf35 (homo sapiens)", "braf1 (homo sapiens)", "braf (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))" ]
Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf35 (mus musculus)", "braf1 (homo sapiens)", "braf (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))" ]
Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brca2 dna repair associated (homo sapiens)" ]
[ "breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans)", "palb2 (homo sapiens)", "bcc2 (homo sapiens)", "fancd2 (homo sapiens)" ]
Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf35 (mus musculus)", "braf1 (homo sapiens)", "braf (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))" ]
Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6-2'?
[ "nkx6-2 (mus musculus)" ]
[ "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6-2 (xenopus tropicalis)" ]
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'gtx'?
[ "gtx (mus musculus)" ]
[ "gtx (homo sapiens)", "gtx (xenopus tropicalis)", "trihelix transcription factor gt-1 (glycine max)", "gtx (drosophila melanogaster)" ]
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6-2'?
[ "nkx6-2 (mus musculus)" ]
[ "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6-2 (xenopus tropicalis)" ]
Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6b (xenopus tropicalis)", "nkx3b (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6a (homo sapiens)" ]
Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', answer the user's query.
What is the biomedical concept corresponding to 'cd58'?
[ "cd58 molecule (homo sapiens)", "cd58 (homo sapiens)" ]
[ "cd5 molecule (homo sapiens)", "cd55 (homo sapiens)", "cd5 (homo sapiens)", "cd52 molecule (homo sapiens)" ]
Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', answer the user's query.
What is the biomedical concept corresponding to 'cd4'?
[ "cd4 molecule (homo sapiens)", "cd4 (homo sapiens)" ]
[ "integrin subunit alpha 4 (homo sapiens)", "itga4 (homo sapiens)", "gp4 (homo sapiens)", "integrin subunit beta 4 (homo sapiens)" ]
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'cd58'?
[ "cd58 molecule (homo sapiens)", "cd58 (homo sapiens)" ]
[ "cd5 molecule (homo sapiens)", "cd55 (homo sapiens)", "cd5 (homo sapiens)", "cd52 molecule (homo sapiens)" ]
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'fos'?
[ "fos (homo sapiens)", "fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "c-fos (homo sapiens)" ]
[ "fos like 1, ap-1 transcription factor subunit (homo sapiens)", "fos (mus musculus)", "fosl1 (homo sapiens)", "fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens)" ]
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'jun'?
[ "jun (homo sapiens)", "c-jun (homo sapiens)", "jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens))" ]
[ "jun (mus musculus)", "junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "jun proto-oncogene (mus musculus)", "juno (homo sapiens)" ]
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'il-2'?
[ "interleukin 2 (homo sapiens)", "il-2 (homo sapiens)", "il2 (homo sapiens)" ]
[ "colony stimulating factor 2 (homo sapiens)", "ilf2 (homo sapiens)", "csf2 (homo sapiens)", "il22 (homo sapiens)" ]
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'c-fos'?
[ "c-fos (homo sapiens)", "fos (homo sapiens)", "fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens)" ]
[ "fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis))", "c-fos (mus musculus)", "c-fos (xenopus tropicalis)" ]
Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', answer the user's query.
What is the biomedical concept corresponding to 'il-2'?
[ "interleukin 2 (homo sapiens)", "il-2 (homo sapiens)", "il2 (homo sapiens)" ]
[ "colony stimulating factor 2 (homo sapiens)", "ilf2 (homo sapiens)", "csf2 (homo sapiens)", "il22 (homo sapiens)" ]
Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)" ]
[ "cd22 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd228 (homo sapiens)" ]
Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', answer the user's query.
What is the biomedical concept corresponding to 'hmast205'?
[ "mast205 (homo sapiens)" ]
[ "mast205 (mus musculus)", "mast205 (drosophila melanogaster)", "tmem205 (sus scrofa)", "tmem205 (homo sapiens)" ]
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'microtubule-associated serine/threonine kinase-205 kda'?
[ "mast205 (homo sapiens)", "microtubule associated serine/threonine kinase 2 (homo sapiens)" ]
[ "mast205 (drosophila melanogaster)", "mast 205 (drosophila melanogaster)", "mast205 (mus musculus)", "microtubule associated serine/threonine kinase 1 (homo sapiens)" ]
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'hmast205'?
[ "mast205 (homo sapiens)" ]
[ "mast205 (mus musculus)", "mast205 (drosophila melanogaster)", "tmem205 (sus scrofa)", "tmem205 (homo sapiens)" ]
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'daxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (drosophila melanogaster)", "daxx (xenopus laevis)", "daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans)", "daxx (xenopus tropicalis)" ]
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)", "hdac2 (homo sapiens)", "rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens))" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 7 (homo sapiens)", "histone deacetylase 9 (homo sapiens)", "histone deacetylase 3 (homo sapiens)" ]
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'chromatin-associated protein dek'?
[ "dek (homo sapiens)", "dek proto-oncogene (homo sapiens)" ]
[ "dek (drosophila melanogaster) (eph receptor tyrosine kinase (drosophila melanogaster))", "dee (homo sapiens)", "dek7 (drosophila melanogaster)", "dek (mus musculus)" ]
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'daxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (drosophila melanogaster)", "daxx (xenopus laevis)", "daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans)", "daxx (xenopus tropicalis)" ]
Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'To determine the mechanism by which hDaxx represses transcription, we used conventional chromatography to isolate endogenous hDaxx.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'We determined that hDaxx has an apparent molecular weight of 360 kDa, which is consistent with the fact that multiple domains of hDaxx are required for transcriptional repression and suggests that hDaxx associates with multiple proteins.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)", "hdac2 (homo sapiens)", "rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens))" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 7 (homo sapiens)", "histone deacetylase 9 (homo sapiens)", "histone deacetylase 3 (homo sapiens)" ]
Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)", "hdac2 (homo sapiens)", "rpd3 (homo sapiens) (histone deacetylase 2 (homo sapiens))" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 7 (homo sapiens)", "histone deacetylase 9 (homo sapiens)", "histone deacetylase 3 (homo sapiens)" ]
Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'Finally, we provide evidence suggesting that the association of hDaxx with chromatin-related proteins is dependent on the post-translational phosphorylation status of hDaxx.', answer the user's query.
What is the biomedical concept corresponding to 'hdaxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (xenopus laevis)", "daxx (xenopus tropicalis)", "axed on x (drosophila melanogaster)", "daxx (drosophila melanogaster)" ]
Given the context 'A working model for the repressive action of hDaxx through its association with chromatin related proteins is presented.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'Regulation of human separase by securin binding and autocleavage. ', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "securin (xenopus laevis)", "securin (caenorhabditis elegans)" ]
Given the context 'Regulation of human separase by securin binding and autocleavage. ', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "securin (xenopus laevis)", "securin (caenorhabditis elegans)" ]
Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (saccharomyces cerevisiae s288c)", "separase (drosophila melanogaster)", "separin homolog sep-1 (caenorhabditis elegans)", "separase (candida albicans sc5314)" ]
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.