instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2]
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
B: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
C: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
D: il2 (homo sapiens) (aka interleukin 2)
E: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
F: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
G: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
H: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
I: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
J: il22 (homo sapiens) (aka interleukin 22)
K: None of the above. | [C; D] |
<Instruct>: Given the context 'Described here is the ability of the novel basic leucine zipper protein p21SNFT to repress AP-1 activity and IL-2 transcription.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2]
<Options>: A: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
B: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
C: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
D: il22 (homo sapiens) (aka interleukin 22)
E: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
F: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
G: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
H: il-2 (homo sapiens) (aka interleukin 2)
I: interleukin 3 (homo sapiens) (aka interleukin 3)
J: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
K: None of the above. | [J; H] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
C: fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
D: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
E: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
F: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
G: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
H: juno (homo sapiens) (aka izumo1 receptor, juno)
I: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
J: fos (mus musculus) (aka fbj osteosarcoma oncogene)
K: il2 (homo sapiens) (aka interleukin 2)
L: il22 (homo sapiens) (aka interleukin 22)
M: csf2 (homo sapiens) (aka colony stimulating factor 2)
N: c-jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
O: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
P: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
Q: interleukin 3 (homo sapiens) (aka interleukin 3)
R: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
S: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
T: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
U: None of the above. | [R; K; N; C] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: fosl1 (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
B: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
C: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
D: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
E: juno (homo sapiens) (aka izumo1 receptor, juno)
F: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
G: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
H: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
I: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
J: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
K: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
L: interleukin 3 (homo sapiens) (aka interleukin 3)
M: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
N: fos (mus musculus) (aka fbj osteosarcoma oncogene)
O: jun (mus musculus) (aka jun proto-oncogene)
P: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
Q: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
R: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
S: il22 (homo sapiens) (aka interleukin 22)
T: il2 (homo sapiens) (aka interleukin 2)
U: None of the above. | [I; T; P; C] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
B: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
C: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
D: fra (homo sapiens) (fos like 1, ap-1 transcription factor subunit (homo sapiens)) (aka fos like 1, ap-1 transcription factor subunit)
E: fos (mus musculus) (aka fbj osteosarcoma oncogene)
F: il2 (homo sapiens) (aka interleukin 2)
G: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
H: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
I: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
J: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
K: il22 (homo sapiens) (aka interleukin 22)
L: fosb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka fosb proto-oncogene, ap-1 transcription factor subunit)
M: jun (mus musculus) (aka jun proto-oncogene)
N: interleukin 3 (homo sapiens) (aka interleukin 3)
O: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
P: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
Q: juno (homo sapiens) (aka izumo1 receptor, juno)
R: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
S: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
T: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
U: None of the above. | [J; F; O; S] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; il-2; jun; fos]
<Options>: A: c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis)) (aka fbj murine osteosarcoma viral oncogene homolog s homeolog)
B: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
C: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
D: c-fos (homo sapiens) (aka fos proto-oncogene, ap-1 transcription factor subunit)
E: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
F: fos (mus musculus) (aka fbj osteosarcoma oncogene)
G: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
H: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
I: interleukin 3 (homo sapiens) (aka interleukin 3)
J: juno (homo sapiens) (aka izumo1 receptor, juno)
K: il22 (homo sapiens) (aka interleukin 22)
L: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
M: fos like 1, ap-1 transcription factor subunit (homo sapiens) (aka fos like 1, ap-1 transcription factor subunit)
N: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
O: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
P: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
Q: nft1 (saccharomyces cerevisiae s288c) (putative multidrug transporter nft1 (saccharomyces cerevisiae s288c)) (aka putative multidrug transporter nft1)
R: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
S: il-2 (homo sapiens) (aka interleukin 2)
T: fos like 2, ap-1 transcription factor subunit (homo sapiens) (aka fos like 2, ap-1 transcription factor subunit)
U: None of the above. | [N; S; R; D] |
<Instruct>: Given the context 'A detailed analysis of the repression by p21SNFT repression on the IL-2 promoter distal NF-AT/AP-1 site demonstrates that it can bind DNA with NF-AT and Jun, strongly suggesting that it represses NF-AT/AP-1 activity by competing with Fos proteins for Jun dimerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [jun]
<Options>: A: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
B: ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)) (aka jun proto-oncogene, ap-1 transcription factor subunit)
C: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
D: juno (homo sapiens) (aka izumo1 receptor, juno)
E: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
F: None of the above. | [B] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; jun; il-2]
<Options>: A: hsnfs (homo sapiens) (aka swi/snf related baf chromatin remodeling complex subunit b1)
B: juno (homo sapiens) (aka izumo1 receptor, juno)
C: il22 (homo sapiens) (aka interleukin 22)
D: jund (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
E: csf2 (homo sapiens) (aka colony stimulating factor 2)
F: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
G: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
H: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
I: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
J: interleukin 2 (homo sapiens) (aka interleukin 2)
K: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
L: c-jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
M: jun (mus musculus) (aka jun proto-oncogene)
N: interleukin 3 (homo sapiens) (aka interleukin 3)
O: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
P: None of the above. | [I; L; J] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; jun; il-2]
<Options>: A: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
B: jun (mus musculus) (aka jun proto-oncogene)
C: jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
D: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
E: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2)
F: juno (homo sapiens) (aka izumo1 receptor, juno)
G: il-2 (homo sapiens) (aka interleukin 2)
H: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
I: il22 (homo sapiens) (aka interleukin 22)
J: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2)
K: interleukin 3 (homo sapiens) (aka interleukin 3)
L: cstf2t (homo sapiens) (aka cleavage stimulation factor subunit 2 tau variant)
M: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
N: cstf2t (rattus norvegicus) (aka cleavage stimulation factor subunit 2, tau variant)
O: putative multidrug transporter nft1 (saccharomyces cerevisiae s288c) (aka putative multidrug transporter nft1)
P: None of the above. | [H; C; G] |
<Instruct>: Given the context 'The importance of this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that contain Jun, thereby demonstrating an additional level of control for the highly regulated, ubiquitous AP-1 transcription factor and the IL-2 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21snft; jun; il-2]
<Options>: A: junb proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka junb proto-oncogene, ap-1 transcription factor subunit)
B: il2 (homo sapiens) (aka interleukin 2)
C: nft1 (saccharomyces cerevisiae s288c) (uncharacterized protein (saccharomyces cerevisiae s288c)) (aka uncharacterized protein)
D: il22 (homo sapiens) (aka interleukin 22)
E: nst1 (saccharomyces cerevisiae s288c) (aka nst1p)
F: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2)
G: juno (homo sapiens) (aka izumo1 receptor, juno)
H: fgf-2 (homo sapiens) (aka fibroblast growth factor 2)
I: jun proto-oncogene (mus musculus) (aka jun proto-oncogene)
J: ntf2 (saccharomyces cerevisiae s288c) (aka ran gtpase-binding protein ntf2)
K: rft1 homolog (rattus norvegicus) (aka rft1 homolog)
L: jun (homo sapiens) (aka jun proto-oncogene, ap-1 transcription factor subunit)
M: snft (homo sapiens) (aka basic leucine zipper atf-like transcription factor 3)
N: jund proto-oncogene, ap-1 transcription factor subunit (homo sapiens) (aka jund proto-oncogene, ap-1 transcription factor subunit)
O: interleukin 3 (homo sapiens) (aka interleukin 3)
P: None of the above. | [M; L; B] |
<Instruct>: Given the context 'Identification of distinct surface-expressed and intracellular CXC-chemokine receptor 2 glycoforms in neutrophils: N-glycosylation is essential for maintenance of receptor surface expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxc-chemokine receptor 2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: chemokine (c-c motif) receptor 2 (xenopus tropicalis) (aka chemokine (c-c motif) receptor 2)
D: atypical chemokine receptor 2 (homo sapiens) (aka atypical chemokine receptor 2)
E: c-x-c motif chemokine receptor 1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: il8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
B: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
C: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
D: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
E: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
F: gro2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
G: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
H: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
I: il1f8 (homo sapiens) (aka interleukin 36 beta)
J: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
K: nap-2 (homo sapiens) (aka pro-platelet basic protein)
L: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
M: ck-8 (homo sapiens) (aka keratin 8)
N: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
O: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
P: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
Q: prokineticin 2 (homo sapiens) (aka prokineticin 2)
R: None of the above. | [J; A; K; K] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: gro2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
B: il8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
C: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
D: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: ck-8 (homo sapiens) (aka keratin 8)
F: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
G: il1f8 (homo sapiens) (aka interleukin 36 beta)
H: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
I: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
J: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
K: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
L: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
M: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
N: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
O: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
P: prokineticin 2 (homo sapiens) (aka prokineticin 2)
Q: None of the above. | [I; B; Q; Q] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: nucleic acid binding protein 2 (homo sapiens) (aka nucleic acid binding protein 2)
B: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
C: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
E: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
F: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
G: il18 (homo sapiens) (aka interleukin 18)
H: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
I: ck-8 (homo sapiens) (aka keratin 8)
J: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
K: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
L: c-x-c motif chemokine ligand 2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
M: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
N: nap-2 (homo sapiens) (aka pro-platelet basic protein)
O: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
P: x-c motif chemokine ligand 2 (homo sapiens) (aka x-c motif chemokine ligand 2)
Q: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
R: None of the above. | [E; J; N; N] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
B: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
C: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
D: nap-2 (homo sapiens) (aka pro-platelet basic protein)
E: il18 (homo sapiens) (aka interleukin 18)
F: c-x-c motif chemokine ligand 2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
G: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
H: nac-2 (homo sapiens) (aka nacc family member 2)
I: neutrophil cytosolic factor 2 (homo sapiens) (aka neutrophil cytosolic factor 2)
J: il1f8 (homo sapiens) (aka interleukin 36 beta)
K: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
L: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
M: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
N: prokineticin 2 (homo sapiens) (aka prokineticin 2)
O: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
P: ck-8 (homo sapiens) (aka keratin 8)
Q: mip-2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
R: None of the above. | [K; G; D; D] |
<Instruct>: Given the context 'The G protein-coupled CXC-chemokine receptor CXCR-2 mediates activation of neutrophil effector functions in response to multiple ligands, including IL-8 and neutrophil-activating peptide 2 (NAP-2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; il-8; neutrophil-activating peptide 2; nap-2]
<Options>: A: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: ck-8 (homo sapiens) (aka keratin 8)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: il18 (homo sapiens) (aka interleukin 18)
E: leukocyte cell derived chemotaxin 2 (homo sapiens) (aka leukocyte cell derived chemotaxin 2)
F: c-x-c motif chemokine ligand 2 (homo sapiens) (aka c-x-c motif chemokine ligand 2)
G: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
H: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
I: nac-2 (homo sapiens) (aka nacc family member 2)
J: nucleic acid binding protein 2 (homo sapiens) (aka nucleic acid binding protein 2)
K: nap-2 (homo sapiens) (aka pro-platelet basic protein)
L: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
M: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
N: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
O: il1f8 (homo sapiens) (aka interleukin 36 beta)
P: mip-2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
Q: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
R: None of the above. | [A; L; K; K] |
<Instruct>: Given the context 'Although CXCR-2 has been successfully cloned and expressed in several cell lines, the molecular properties of the native neutrophil-expressed receptor have remained largely undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2]
<Options>: A: ccr2b (homo sapiens) (aka c-c motif chemokine receptor 2)
B: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'Here we report on the identification and characterization of distinct CXCR-2 glycoforms and their subcellular distribution in neutrophils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2]
<Options>: A: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [A] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: ck-8 (homo sapiens) (aka keratin 8)
D: nap-2 (homo sapiens) (aka pro-platelet basic protein)
E: il18 (homo sapiens) (aka interleukin 18)
F: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
G: nabp2 (homo sapiens) (aka nucleic acid binding protein 2)
H: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
I: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
J: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
K: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
L: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
M: il1f8 (homo sapiens) (aka interleukin 36 beta)
N: None of the above. | [I; D; A] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
B: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
F: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
G: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
H: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
I: il1f8 (homo sapiens) (aka interleukin 36 beta)
J: nap-2 (homo sapiens) (aka pro-platelet basic protein)
K: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
L: nac-2 (homo sapiens) (aka nacc family member 2)
M: ck-8 (homo sapiens) (aka keratin 8)
N: None of the above. | [H; J; C] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
B: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
C: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
E: nac-2 (homo sapiens) (aka nacc family member 2)
F: ck-8 (homo sapiens) (aka keratin 8)
G: il1f8 (homo sapiens) (aka interleukin 36 beta)
H: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
I: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
J: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
K: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
L: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
M: None of the above. | [B; M; C] |
<Instruct>: Given the context 'Immunoprecipitation and Western blot analyses of surface-expressed receptors covalently linked to IL-8 or NAP-2 as well as in their unloaded state revealed the occurrence of a single CXCR-2 variant with an apparent size of 56 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-8; nap-2; cxcr-2]
<Options>: A: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: nap-2 (homo sapiens) (aka pro-platelet basic protein)
D: ck-8 (homo sapiens) (aka keratin 8)
E: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
F: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
G: nabp2 (homo sapiens) (aka nucleic acid binding protein 2)
H: il1f8 (homo sapiens) (aka interleukin 36 beta)
I: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
J: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
K: ccl8 (homo sapiens) (aka c-c motif chemokine ligand 8)
L: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
M: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
N: None of the above. | [L; C; E] |
<Instruct>: Given the context 'According to deglycosylation experiments surface-expressed CXCR-2 carries two N-linked 9-kDa carbohydrate moieties that are both of complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2]
<Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'In addition, two other CXCR-2 variants of 38 and 40 kDa were found to occur exclusively intracellular and to carry N-glycosylations of high mannose or hybrid type.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2]
<Options>: A: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
B: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; nap-2]
<Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
C: cxcr2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
D: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
E: napp2 (homo sapiens) (aka peroxisomal biogenesis factor 14)
F: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
G: nap-2 (homo sapiens) (aka pro-platelet basic protein)
H: nucleic acid binding protein 2 (homo sapiens) (aka nucleic acid binding protein 2)
I: None of the above. | [C; G] |
<Instruct>: Given the context 'These receptors did not participate in ligand-induced receptor trafficking, while surface-expressed CXCR-2 was internalized and re-expressed following stimulation with NAP-2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; nap-2]
<Options>: A: nap-2 (homo sapiens) (aka pro-platelet basic protein)
B: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
C: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
D: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
E: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
G: nac-2 (homo sapiens) (aka nacc family member 2)
H: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
I: None of the above. | [H; A] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; nap-2]
<Options>: A: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
B: nabp2 (homo sapiens) (aka nucleic acid binding protein 2)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: c-x-c motif chemokine receptor 2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
E: nap2l (homo sapiens) (aka nucleosome assembly protein 1 like 4)
F: nap-2 (homo sapiens) (aka pro-platelet basic protein)
G: nac-2 (homo sapiens) (aka nacc family member 2)
H: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
I: None of the above. | [D; F] |
<Instruct>: Given the context 'By enzymatic removal of one 9-kDa carbohydrate moiety in surface-expressed CXCR-2 we can show that neither NAP-2-induced trafficking nor signaling of the receptor is dependent on its full glycosylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2; nap-2]
<Options>: A: il8r2 (homo sapiens) (aka c-x-c motif chemokine receptor 2)
B: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: nap-2 (homo sapiens) (aka pro-platelet basic protein)
D: nipsnap homolog 2 (xenopus tropicalis) (aka nipsnap homolog 2)
E: ngfi-a binding protein 2 (homo sapiens) (aka ngfi-a binding protein 2)
F: nipsnap homolog 2 (homo sapiens) (aka nipsnap homolog 2)
G: nap2 (homo sapiens) (napsin b aspartic peptidase (pseudogene) (homo sapiens)) (aka napsin b aspartic peptidase (pseudogene))
H: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
I: None of the above. | [A; C] |
<Instruct>: Given the context 'Instead, glycosylation was found to protect CXCR-2 from proteolytic attack, as even partial deglycosylation is associated with serine protease-mediated disappearance of the receptor from the neutrophil surface.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr-2]
<Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: il8rb (homo sapiens) (aka c-x-c motif chemokine receptor 2)
C: c-c motif chemokine receptor like 2 (homo sapiens) (aka c-c motif chemokine receptor like 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: katp-2 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 6)
B: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: potassium two pore domain channel subfamily k member 2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
G: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
H: kcnc2 (homo sapiens) (aka potassium voltage-gated channel subfamily c member 2)
I: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; 2p domain mechano-sensitive k+ channel]
<Options>: A: potassium two pore domain channel subfamily k member 4 (homo sapiens) (aka potassium two pore domain channel subfamily k member 4)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
F: potassium two pore domain channel subfamily k member 2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
G: potassium channel subfamily k member 16-like (sus scrofa) (aka potassium channel subfamily k member 16-like)
H: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
I: None of the above. | [B; B] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
G: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
H: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
I: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
J: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
K: None of the above. | [G; D] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
E: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
G: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
H: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
I: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
J: None of the above. | [I; J] |
<Instruct>: Given the context 'This channel, called TREK2, is closely related to TREK1 (78% of homology).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2; trek1]
<Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: task-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
G: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
H: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
I: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
J: None of the above. | [F; I] |
<Instruct>: Given the context 'TREK2 is abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
E: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | [A] |
<Instruct>: Given the context 'In the central nervous system, TREK2 has a widespread distribution with the highest levels of expression in cerebellum, occipital lobe, putamen, and thalamus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: None of the above. | [D] |
<Instruct>: Given the context 'In transfected cells, TREK2 produces rapidly activating and non-inactivating outward rectifier K(+) currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
C: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | [D] |
<Instruct>: Given the context 'TREK2 is blocked by application of intracellular cAMP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
C: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
D: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: None of the above. | [E] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek1; trek2]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
E: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
F: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
G: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
H: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
I: trek-1 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 2)
J: None of the above. | [C; B] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek1; trek2]
<Options>: A: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
C: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
D: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
E: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
F: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
G: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
H: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
I: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
J: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
K: None of the above. | [C; D] |
<Instruct>: Given the context 'As with TREK1, TREK2 is activated by the volatile general anesthetics chloroform, halothane, and isoflurane and by the neuroprotective agent riluzole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek1; trek2]
<Options>: A: trek-1 (mus musculus) (aka potassium channel, subfamily k, member 2)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
D: tresk (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: task1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 3)
G: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
H: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
I: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
J: None of the above. | [J; B] |
<Instruct>: Given the context 'TREK2 can be positively or negatively regulated by a variety of neurotransmitter receptors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
B: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
D: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: None of the above. | [C] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
B: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: 5-hydroxytryptamine receptor 4 (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
D: mglur1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
E: somatostatin receptor 4 (homo sapiens) (aka somatostatin receptor 4)
F: glur-1 (mus musculus) (aka glutamate receptor, ionotropic, ampa1 (alpha 1))
G: mglu2 (homo sapiens) (aka glutamate metabotropic receptor 2)
H: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
I: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
J: mglur5 (homo sapiens) (aka glutamate metabotropic receptor 5)
K: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
L: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
M: mglu1 (homo sapiens) (aka glutamate metabotropic receptor 1)
N: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
O: glurr2 (homo sapiens) (aka polr2m pseudogene 1)
P: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
Q: 5-hydroxytryptamine receptor 4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
R: htr4 (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
S: glur-2 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 2)
T: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
U: None of the above. | [R; M; G; L] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
B: mglu1 (homo sapiens) (aka glutamate metabotropic receptor 1)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: mglur1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
E: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
F: gpr2 (homo sapiens) (aka c-c motif chemokine receptor 10)
G: glr-1 (mus musculus) (aka glutamate receptor, ionotropic, ampa1 (alpha 1))
H: corticotropin releasing hormone receptor 2 (mus musculus) (aka corticotropin releasing hormone receptor 2)
I: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
J: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
K: mglur5 (homo sapiens) (aka glutamate metabotropic receptor 5)
L: somatostatin receptor 4 (homo sapiens) (aka somatostatin receptor 4)
M: 5-ht4r (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
N: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
O: 5-hydroxytryptamine receptor 4 (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
P: glutamate metabotropic receptor 2 (homo sapiens) (aka glutamate metabotropic receptor 2)
Q: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
R: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
S: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
T: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
U: None of the above. | [M; B; P; A] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
B: trek-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: 5-ht4r (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
D: somatostatin receptor 4 (homo sapiens) (aka somatostatin receptor 4)
E: tresk-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
F: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
G: 5-hydroxytryptamine receptor 4 (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
H: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
I: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
J: glurr2 (homo sapiens) (aka polr2m pseudogene 1)
K: glutamate receptor, metabotropic 1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
L: mglu2 (homo sapiens) (aka glutamate metabotropic receptor 2)
M: mglur1 (homo sapiens) (aka glutamate metabotropic receptor 1)
N: glur-1 (mus musculus) (aka glutamate receptor, ionotropic, ampa1 (alpha 1))
O: mglur2 (mus musculus) (aka glutamate receptor, metabotropic 2)
P: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
Q: glur-2 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 2)
R: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
S: 5-hydroxytryptamine receptor 4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
T: metabotropic glutamate receptor 1 (xenopus tropicalis) (aka metabotropic glutamate receptor 1)
U: None of the above. | [G; M; L; B] |
<Instruct>: Given the context 'Stimulation of the G(s)-coupled receptor 5HT4sR or the G(q)-coupled receptor mGluR1 inhibits channel activity, whereas activation of the G(i)-coupled receptor mGluR2 increases TREK2 currents.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [5ht4sr; mglur1; mglur2; trek2]
<Options>: A: mglur5 (homo sapiens) (aka glutamate metabotropic receptor 5)
B: trek1 (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
C: corticotropin releasing hormone receptor 2 (mus musculus) (aka corticotropin releasing hormone receptor 2)
D: 5-ht4r (homo sapiens) (aka 5-hydroxytryptamine receptor 4)
E: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
F: sstr4 (homo sapiens) (aka somatostatin receptor 4)
G: vn1r4 (homo sapiens) (aka vomeronasal 1 receptor 4)
H: glr-1 (mus musculus) (aka glutamate receptor, ionotropic, ampa1 (alpha 1))
I: htr4 (rattus norvegicus) (aka 5-hydroxytryptamine receptor 4)
J: mglu1 (homo sapiens) (aka glutamate metabotropic receptor 1)
K: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
L: mglur1 (xenopus tropicalis) (aka glutamate receptor, metabotropic 1)
M: grm2 (homo sapiens) (aka glutamate metabotropic receptor 2)
N: glur-2 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 2)
O: 5-hydroxytryptamine receptor 4 (sus scrofa) (aka 5-hydroxytryptamine receptor 4)
P: glurr2 (homo sapiens) (aka polr2m pseudogene 1)
Q: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
R: mglur1 (mus musculus) (aka glutamate receptor, metabotropic 1)
S: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
T: task-2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
U: None of the above. | [D; J; M; K] |
<Instruct>: Given the context 'These multiple types of regulations suggest that TREK2 plays an important role as a target of neurotransmitter action.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trek2]
<Options>: A: trek (homo sapiens) (aka potassium two pore domain channel subfamily k member 2)
B: trek2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 10)
C: tresk2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 18)
D: task2 (homo sapiens) (aka potassium two pore domain channel subfamily k member 5)
E: trek-2 (xenopus tropicalis) (aka potassium channel, two pore domain subfamily k, member 10)
F: None of the above. | [B] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; interleukin-6]
<Options>: A: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
B: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
C: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: il6 (homo sapiens) (aka interleukin 6)
F: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
G: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
H: il7 (homo sapiens) (aka interleukin 7)
I: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
J: None of the above. | [C; E] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; interleukin-6]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
D: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: il7 (homo sapiens) (aka interleukin 7)
G: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
I: None of the above. | [G; I] |
<Instruct>: Given the context 'SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; interleukin-6]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
D: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
F: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
G: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
H: il-6 (homo sapiens) (aka interleukin 6)
I: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
J: None of the above. | [D; H] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: pyk2 (saccharomyces cerevisiae s288c) (aka pyruvate kinase pyk2)
E: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
F: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
G: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
H: fak2 (homo sapiens) (aka protein tyrosine kinase 2 beta)
I: pyk2 (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
J: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
K: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
L: frnk (homo sapiens) (aka protein tyrosine kinase 2)
M: il6 (homo sapiens) (aka interleukin 6)
N: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
O: frk (drosophila melanogaster) (aka franklin)
P: fak2 (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
Q: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
R: None of the above. | [H; H; H; M] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: frk (drosophila melanogaster) (aka franklin)
B: pyk2 (saccharomyces cerevisiae s288c) (aka pyruvate kinase pyk2)
C: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
D: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
E: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
F: interleukin 6 (homo sapiens) (aka interleukin 6)
G: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
H: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
I: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
J: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
K: pank2 (homo sapiens) (aka pantothenate kinase 2)
L: pyk (homo sapiens) (aka phosphorylase kinase regulatory subunit alpha 2)
M: frk (bos taurus) (aka fyn related src family tyrosine kinase)
N: interleukin 7 (homo sapiens) (aka interleukin 7)
O: frnk (homo sapiens) (aka protein tyrosine kinase 2)
P: None of the above. | [E; E; E; F] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: pyk (homo sapiens) (aka phosphorylase kinase regulatory subunit alpha 2)
B: interleukin 6 (homo sapiens) (aka interleukin 6)
C: frk (bos taurus) (aka fyn related src family tyrosine kinase)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
F: pyk2 (saccharomyces cerevisiae s288c) (aka pyruvate kinase pyk2)
G: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
H: pank2 (homo sapiens) (aka pantothenate kinase 2)
I: focal adhesion kinase (drosophila melanogaster) (aka focal adhesion kinase)
J: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
K: pyk-2 (caenorhabditis elegans) (aka pyruvate kinase)
L: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
M: frk (drosophila melanogaster) (aka franklin)
N: frnk (homo sapiens) (aka protein tyrosine kinase 2)
O: None of the above. | [O; O; O; B] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: fak2 (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
D: pyk2 (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
E: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
F: frnk (homo sapiens) (aka protein tyrosine kinase 2)
G: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
H: frk (drosophila melanogaster) (aka franklin)
I: pank2 (homo sapiens) (aka pantothenate kinase 2)
J: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
K: interleukin 7 (homo sapiens) (aka interleukin 7)
L: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
M: fak (homo sapiens) (aka protein tyrosine kinase 2)
N: pyruvate kinase pyk2 (saccharomyces cerevisiae s288c) (aka pyruvate kinase pyk2)
O: pdpk2 (homo sapiens) (aka 3-phosphoinositide dependent protein kinase 1)
P: frk (bos taurus) (aka fyn related src family tyrosine kinase)
Q: None of the above. | [A; A; A; B] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [related adhesion focal tyrosine kinase; raftk; pyk2; interleukin-6]
<Options>: A: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
B: pank2 (homo sapiens) (aka pantothenate kinase 2)
C: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
D: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
E: fak (homo sapiens) (aka protein tyrosine kinase 2)
F: il7 (homo sapiens) (aka interleukin 7)
G: tyk2 (homo sapiens) (aka tyrosine kinase 2)
H: frk (drosophila melanogaster) (aka franklin)
I: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
J: pyk2 (saccharomyces cerevisiae s288c) (aka pyruvate kinase pyk2)
K: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
L: frnk (homo sapiens) (aka protein tyrosine kinase 2)
M: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
N: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
O: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
P: pyk (homo sapiens) (aka phosphorylase kinase regulatory subunit alpha 2)
Q: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
R: None of the above. | [C; C; C; N] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; raftk]
<Options>: A: il6 (homo sapiens) (aka interleukin 6)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: frnk (homo sapiens) (aka protein tyrosine kinase 2)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: interleukin 7 (homo sapiens) (aka interleukin 7)
F: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
G: frk (drosophila melanogaster) (aka franklin)
H: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
I: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
J: None of the above. | [A; B] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; raftk]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
C: frk (drosophila melanogaster) (aka franklin)
D: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
E: frnk (homo sapiens) (aka protein tyrosine kinase 2)
F: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
G: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
H: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
I: None of the above. | [I; D] |
<Instruct>: Given the context 'Our previous studies have shown that activation of a related adhesion focal tyrosine kinase (RAFTK) (also known as Pyk2) is required for dexamethasone (Dex)-induced apoptosis in multiple myeloma (MM) cells and that human interleukin-6 (IL-6), a known growth and survival factor for MM cells, blocks both RAFTK activation and apoptosis induced by Dex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; raftk]
<Options>: A: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
E: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
F: il-6 (homo sapiens) (aka interleukin 6)
G: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
H: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
I: frnk (homo sapiens) (aka protein tyrosine kinase 2)
J: None of the above. | [F; A] |
<Instruct>: Given the context 'However, the mechanism whereby IL-6 inhibits Dex-induced apoptosis is undefined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6]
<Options>: A: interleukin 7 (homo sapiens) (aka interleukin 7)
B: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
D: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
E: None of the above. | [B] |
<Instruct>: Given the context 'In this study, we demonstrate that protein-tyrosine phosphatase SHP2 mediates this protective effect.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2]
<Options>: A: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
E: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: il6 (homo sapiens) (aka interleukin 6)
B: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
C: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
D: interleukin 7 (homo sapiens) (aka interleukin 7)
E: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
F: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
G: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
I: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
J: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
K: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
L: frk (bos taurus) (aka fyn related src family tyrosine kinase)
M: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
N: frk (drosophila melanogaster) (aka franklin)
O: None of the above. | [A; G; J] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
C: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
D: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
E: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
F: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
G: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
I: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
J: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
K: interleukin 7 (homo sapiens) (aka interleukin 7)
L: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
M: il-6 (homo sapiens) (aka interleukin 6)
N: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
O: None of the above. | [M; G; H] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
D: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
E: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
F: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
G: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
I: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
J: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
K: interleukin 7 (homo sapiens) (aka interleukin 7)
L: hbgf-6 (homo sapiens) (aka fibroblast growth factor 6)
M: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
N: None of the above. | [N; G; B] |
<Instruct>: Given the context 'We show that IL-6 triggers selective activation of SHP2 and its association with RAFTK in Dex-treated MM cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-6; shp2; raftk]
<Options>: A: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
B: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
C: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
D: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
E: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
F: il-6 (homo sapiens) (aka interleukin 6)
G: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
I: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
J: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
K: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
L: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
M: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
N: interleukin 7 (homo sapiens) (aka interleukin 7)
O: None of the above. | [F; G; B] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
C: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
D: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
E: frk (gallus gallus) (aka fyn related src family tyrosine kinase)
F: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
G: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
H: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
I: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
J: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'SHP2 interacts with RAFTK through a region other than its Src homology 2 domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; raftk]
<Options>: A: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
B: frk (bos taurus) (aka fyn related src family tyrosine kinase)
C: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
D: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
E: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
F: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
G: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
H: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
I: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
J: frk (xenopus tropicalis) (aka fyn related src family tyrosine kinase)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [raftk; shp2]
<Options>: A: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
B: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
D: frk (homo sapiens) (aka fyn related src family tyrosine kinase)
E: frnk (homo sapiens) (aka protein tyrosine kinase 2)
F: raftk (xenopus laevis) (protein tyrosine kinase 2 beta s homeolog (xenopus laevis)) (aka protein tyrosine kinase 2 beta s homeolog)
G: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
H: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
I: frk (drosophila melanogaster) (aka franklin)
J: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
K: None of the above. | [G; B] |
<Instruct>: Given the context 'We demonstrate that RAFTK is a direct substrate of SHP2 both in vitro and in vivo, and that Tyr(906) in the C-terminal domain of RAFTK mediates its interaction with SHP2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [raftk; shp2]
<Options>: A: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
B: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
D: raftk (xenopus tropicalis) (aka protein tyrosine kinase 2 beta)
E: raftk (mus musculus) (aka ptk2 protein tyrosine kinase 2 beta)
F: frk (drosophila melanogaster) (aka franklin)
G: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
H: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
I: frnk (homo sapiens) (aka protein tyrosine kinase 2)
J: raftk (homo sapiens) (aka protein tyrosine kinase 2 beta)
K: None of the above. | [J; B] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; il-6]
<Options>: A: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
B: il6 (homo sapiens) (aka interleukin 6)
C: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
D: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
E: sh-ptp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
F: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
G: interleukin 7 (homo sapiens) (aka interleukin 7)
H: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
I: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
J: None of the above. | [E; B] |
<Instruct>: Given the context 'Moreover, overexpression of dominant negative SHP2 blocked the protective effect of IL-6 against Dex-induced apoptosis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; il-6]
<Options>: A: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
B: shp2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
C: cdf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
F: interleukin 7 (homo sapiens) (aka interleukin 7)
G: ptpn2p1 (homo sapiens) (aka ptpn2 pseudogene 1)
H: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
I: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
J: None of the above. | [B; C] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; il-6]
<Options>: A: ptpn2p (homo sapiens) (aka ptpn2 pseudogene 1)
B: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
C: lif interleukin 6 family cytokine (homo sapiens) (aka lif interleukin 6 family cytokine)
D: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
E: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
F: protein tyrosine phosphatase non-receptor type 2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
G: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
H: il-6 (homo sapiens) (aka interleukin 6)
I: interleukin 7 (homo sapiens) (aka interleukin 7)
J: None of the above. | [E; H] |
<Instruct>: Given the context 'These findings demonstrate that SHP2 mediates the anti-apoptotic effect of IL-6 and suggest SHP2 as a novel therapeutic target in MM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shp2; il-6]
<Options>: A: ptp2c (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 11)
B: ptp1b (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 1)
C: fibroblast growth factor 6 (homo sapiens) (aka fibroblast growth factor 6)
D: ptpn2 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 2)
E: il6 (homo sapiens) (aka interleukin 6)
F: interleukin 7 (homo sapiens) (aka interleukin 7)
G: ptpn12 (homo sapiens) (aka protein tyrosine phosphatase non-receptor type 12)
H: ptpn2p2 (homo sapiens) (aka ptpn2 pseudogene 2)
I: cdf (homo sapiens) (lif interleukin 6 family cytokine (homo sapiens)) (aka lif interleukin 6 family cytokine)
J: None of the above. | [A; E] |
<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha(2a) adrenoceptor]
<Options>: A: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
B: adra2r (homo sapiens) (aka adrenoceptor alpha 2a)
C: alpha2bar (homo sapiens) (aka adrenoceptor alpha 2b)
D: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
E: None of the above. | [B] |
<Instruct>: Given the context 'Here, we examined the effect of alpha(2) agonists on a clone of Caco2 cells expressing the human alpha(2A) adrenoceptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha(2a) adrenoceptor]
<Options>: A: alpha2car (homo sapiens) (aka adrenoceptor alpha 2c)
B: alpha2bar (homo sapiens) (aka adrenoceptor alpha 2b)
C: adrenoceptor alpha 1b (homo sapiens) (aka adrenoceptor alpha 1b)
D: None of the above. | [D] |
<Instruct>: Given the context 'Cells were transfected with a bicistronic plasmid containing the alpha2C10 and neomycin phosphotransferase genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha2c10]
<Options>: A: cyclic nucleotide gated channel subunit alpha 2 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 2)
B: integrin subunit alpha 10 (homo sapiens) (aka integrin subunit alpha 10)
C: hist2h2ac (homo sapiens) (aka h2a clustered histone 20)
D: alpha2aar (homo sapiens) (aka adrenoceptor alpha 2a)
E: pcdh-alpha10 (homo sapiens) (aka protocadherin alpha 10)
F: None of the above. | [D] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: mitogen-activated protein kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
B: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
C: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
D: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
E: erk8 (homo sapiens) (aka mitogen-activated protein kinase 15)
F: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
G: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
H: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
I: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
J: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
K: sapk2b (homo sapiens) (aka mitogen-activated protein kinase 11)
L: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
M: mapkk2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
N: erk-2 (homo sapiens) (aka mitogen-activated protein kinase 1)
O: None of the above. | [L; L; N] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk2 (homo sapiens) (aka mitogen-activated protein kinase 1)
B: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
C: mitogen-activated protein kinase kinase 1 (homo sapiens) (aka mitogen-activated protein kinase kinase 1)
D: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
E: mapkk2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
F: erk-2 (homo sapiens) (aka mitogen-activated protein kinase 1)
G: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
H: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
I: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
J: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
K: erk1 (homo sapiens) (aka mitogen-activated protein kinase 3)
L: None of the above. | [J; J; F] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
B: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
C: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
D: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
E: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
F: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
G: erk-2 (homo sapiens) (aka mitogen-activated protein kinase 1)
H: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
I: mitogen-activated protein kinase kinase 2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
J: sapk2 (homo sapiens) (aka mitogen-activated protein kinase 11)
K: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
L: None of the above. | [H; H; G] |
<Instruct>: Given the context 'Treatment of Caco2-3B with UK14304 (alpha(2) agonist) induced a rapid increase in the phosphorylation state of MAPK, extracellular regulated protein kinase 1 (Erk1), and 2 (Erk2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [extracellular regulated protein kinase 1; erk1; erk2]
<Options>: A: erk2 (xenopus tropicalis) (aka mitogen-activated protein kinase 1)
B: erk-6 (homo sapiens) (aka mitogen-activated protein kinase 12)
C: erk-1 (homo sapiens) (aka mitogen-activated protein kinase 3)
D: erk2 (mus musculus) (aka mitogen-activated protein kinase 1)
E: mitogen-activated protein kinase 1 (homo sapiens) (aka mitogen-activated protein kinase 1)
F: erk6 (homo sapiens) (aka mitogen-activated protein kinase 12)
G: erk5 (homo sapiens) (aka mitogen-activated protein kinase 7)
H: sapk2 (homo sapiens) (aka mitogen-activated protein kinase 11)
I: erk7 (homo sapiens) (aka mitogen-activated protein kinase 15)
J: mitogen-activated protein kinase kinase 2 (homo sapiens) (aka mitogen-activated protein kinase kinase 2)
K: None of the above. | [C; C; K] |
<Instruct>: Given the context 'It was unaffected by protein kinase C downregulation but correlated with a transient increase in Shc tyrosine phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [shc]
<Options>: A: n-shc (homo sapiens) (aka shc adaptor protein 3)
B: shc adaptor protein 1 (homo sapiens) (aka shc adaptor protein 1)
C: shcb (homo sapiens) (aka shc adaptor protein 2)
D: None of the above. | [B] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
B: il-4 (bos taurus) (aka interleukin 4)
C: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
E: il4 (homo sapiens) (aka interleukin 4)
F: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
G: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
H: ifi-30 (homo sapiens) (aka ifi30 lysosomal thiol reductase)
I: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
J: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
K: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
L: interleukin 5 (homo sapiens) (aka interleukin 5)
M: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
N: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
O: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
P: il-10c (homo sapiens) (aka interleukin 19)
Q: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
R: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
S: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
T: None of the above. | [E; G; M; M] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: il-10a (homo sapiens) (aka interleukin 10)
E: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
G: ifi11 (homo sapiens) (aka immunity related gtpase m)
H: ifitm10 (homo sapiens) (aka interferon induced transmembrane protein 10)
I: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
J: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
K: interleukin 4 (homo sapiens) (aka interleukin 4)
L: il-4 (bos taurus) (aka interleukin 4)
M: il-10c (homo sapiens) (aka interleukin 19)
N: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
O: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
P: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
Q: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
R: interleukin 5 (homo sapiens) (aka interleukin 5)
S: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
T: None of the above. | [K; E; A; A] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
B: ifi11 (homo sapiens) (aka immunity related gtpase m)
C: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
D: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
E: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
F: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
G: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
H: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
I: interleukin 5 (homo sapiens) (aka interleukin 5)
J: il-10a (homo sapiens) (aka interleukin 10)
K: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
L: il-10c (homo sapiens) (aka interleukin 19)
M: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
N: il-4 (homo sapiens) (aka interleukin 4)
O: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
P: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
Q: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
R: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
S: il4 (bos taurus) (aka interleukin 4)
T: None of the above. | [N; F; R; R] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; cxcr3; ifn-induced protein of 10 kda; ip-10]
<Options>: A: ifi30 (homo sapiens) (aka ifi30 lysosomal thiol reductase)
B: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
D: ifi11 (homo sapiens) (aka immunity related gtpase m)
E: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
F: il-10c (homo sapiens) (aka interleukin 19)
G: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
H: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
I: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
J: interleukin 10 (homo sapiens) (aka interleukin 10)
K: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
L: interleukin 5 (homo sapiens) (aka interleukin 5)
M: il-4 (bos taurus) (aka interleukin 4)
N: il-4 (homo sapiens) (aka interleukin 4)
O: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
P: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
Q: ifi-78k (homo sapiens) (aka mx dynamin like gtpase 1)
R: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
S: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
T: None of the above. | [N; E; B; B] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
E: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
F: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
G: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
H: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
I: midkine (homo sapiens) (aka midkine)
J: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
K: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
L: c-c motif chemokine ligand 28 (homo sapiens) (aka c-c motif chemokine ligand 28)
M: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
N: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
O: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
P: tac1 (homo sapiens) (aka tachykinin precursor 1)
Q: mip-2g (homo sapiens) (aka c-x-c motif chemokine ligand 14)
R: None of the above. | [K; K; C; C] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
B: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
C: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
D: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
E: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
F: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
G: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
H: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
I: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
J: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
K: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
L: mig10 (homo sapiens) (aka phosphoglycerate kinase 1)
M: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
N: ifn-alphac (homo sapiens) (aka interferon alpha 10)
O: tac1 (homo sapiens) (aka tachykinin precursor 1)
P: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
Q: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
R: None of the above. | [J; J; G; G] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: scya27 (homo sapiens) (aka c-c motif chemokine ligand 27)
B: ifn-alphac (homo sapiens) (aka interferon alpha 10)
C: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
D: ik cytokine (homo sapiens) (aka ik cytokine)
E: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
F: c-c motif chemokine ligand 28 (homo sapiens) (aka c-c motif chemokine ligand 28)
G: mip-3 (homo sapiens) (aka c-c motif chemokine ligand 23)
H: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
I: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
J: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
K: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
L: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
M: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
N: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
O: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
P: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
Q: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
R: None of the above. | [H; H; K; K] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [monokine induced by ifn-gamma; mig; ifn-inducible t-cell alpha-chemoattractant; i-tac]
<Options>: A: ifi78 (homo sapiens) (aka mx dynamin like gtpase 1)
B: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
C: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
D: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
E: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
F: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
G: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
H: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
I: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
J: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
K: midkine (homo sapiens) (aka midkine)
L: mig9 (homo sapiens) (aka s100 calcium binding protein p)
M: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
N: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
O: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
P: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
Q: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
R: None of the above. | [P; P; M; M] |
<Instruct>: Given the context 'IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines.
IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cxcr3 receptor]
<Options>: A: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
C: atypical chemokine receptor 3 (xenopus tropicalis) (aka atypical chemokine receptor 3)
D: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
E: cxcr3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: interleukin 17f (homo sapiens) (aka interleukin 17f)
B: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: il-10c (homo sapiens) (aka interleukin 19)
D: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
E: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
F: il-17a (homo sapiens) (aka interleukin 17a)
G: il-17c (homo sapiens) (aka interleukin 17c)
H: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
I: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
J: il10 (homo sapiens) (aka interleukin 10)
K: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
L: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
M: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
N: il-4 (bos taurus) (aka interleukin 4)
O: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
P: il4 (homo sapiens) (aka interleukin 4)
Q: interleukin 10 (bos taurus) (aka interleukin 10)
R: il-17 (bos taurus) (aka interleukin 17a)
S: None of the above. | [P; J; F; K] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: il-4 (homo sapiens) (aka interleukin 4)
C: interleukin 5 (homo sapiens) (aka interleukin 5)
D: il-17 (bos taurus) (aka interleukin 17a)
E: il17 (homo sapiens) (aka interleukin 17a)
F: il10 (homo sapiens) (aka interleukin 10)
G: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
H: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
I: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
J: interleukin 17f (homo sapiens) (aka interleukin 17f)
K: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
L: interleukin 10 (homo sapiens) (aka interleukin 10)
M: interleukin 10 (bos taurus) (aka interleukin 10)
N: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
O: interleukin 17c (homo sapiens) (aka interleukin 17c)
P: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
Q: il-10 (oryctolagus cuniculus) (aka interleukin 10)
R: gip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
S: None of the above. | [B; F; E; R] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: il-10c (homo sapiens) (aka interleukin 19)
B: il10 (homo sapiens) (aka interleukin 10)
C: il-17f (homo sapiens) (aka interleukin 17f)
D: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
E: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
F: il4 (homo sapiens) (aka interleukin 4)
G: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
H: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
I: il-17 (bos taurus) (aka interleukin 17a)
J: il-17 (homo sapiens) (aka interleukin 17a)
K: interleukin 5 (homo sapiens) (aka interleukin 5)
L: il-10a (homo sapiens) (aka interleukin 10)
M: interleukin 10 (bos taurus) (aka interleukin 10)
N: il-17c (homo sapiens) (aka interleukin 17c)
O: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
P: interleukin 4 (bos taurus) (aka interleukin 4)
Q: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
R: None of the above. | [F; B; J; Q] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
B: il-17f (homo sapiens) (aka interleukin 17f)
C: il-10c (homo sapiens) (aka interleukin 19)
D: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
E: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
F: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
G: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
H: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
I: il-17 (bos taurus) (aka interleukin 17a)
J: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
K: il4 (bos taurus) (aka interleukin 4)
L: interleukin 10 (oryctolagus cuniculus) (aka interleukin 10)
M: il-17c (homo sapiens) (aka interleukin 17c)
N: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
O: interleukin 4 (homo sapiens) (aka interleukin 4)
P: interleukin 10 (homo sapiens) (aka interleukin 10)
Q: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
R: il-17a (homo sapiens) (aka interleukin 17a)
S: None of the above. | [O; P; R; G] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ip-10]
<Options>: A: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
B: il-17c (homo sapiens) (aka interleukin 17c)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: scya10 (homo sapiens) (aka c-c motif chemokine ligand 8)
E: il-17a (homo sapiens) (aka interleukin 17a)
F: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
G: il-10c (homo sapiens) (aka interleukin 19)
H: interleukin 10 (oryctolagus cuniculus) (aka interleukin 10)
I: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
J: il-17f (homo sapiens) (aka interleukin 17f)
K: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
L: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
M: c-x-c motif chemokine ligand 10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
N: il-17 (bos taurus) (aka interleukin 17a)
O: interferon alpha 10 (homo sapiens) (aka interferon alpha 10)
P: il4 (bos taurus) (aka interleukin 4)
Q: interleukin 4 (homo sapiens) (aka interleukin 4)
R: None of the above. | [Q; R; E; M] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
D: tac1 (homo sapiens) (aka tachykinin precursor 1)
E: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
F: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
G: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
H: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
I: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
J: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
K: taci (homo sapiens) (aka tnf receptor superfamily member 13b)
L: mig9 (homo sapiens) (aka s100 calcium binding protein p)
M: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
N: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
O: i-309 (homo sapiens) (aka c-c motif chemokine ligand 1)
P: None of the above. | [H; C; J] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
B: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
C: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
D: mig11 (homo sapiens) (aka molybdenum cofactor synthesis 1)
E: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
F: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
G: c-sis (homo sapiens) (aka platelet derived growth factor subunit b)
H: cxcr3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
I: c-x-c motif chemokine receptor 3 gene 2 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3 gene 2)
J: mig15 (homo sapiens) (aka delta 4-desaturase, sphingolipid 1)
K: mig-14 (homo sapiens) (aka wnt ligand secretion mediator)
L: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
M: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
N: cc-ckr-3 (homo sapiens) (aka c-c motif chemokine receptor 3)
O: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
P: None of the above. | [C; E; H] |
<Instruct>: Given the context 'In this study, we evaluated the capacity of the T cell-derived cytokines IL-4, IL-10, and IL-17 to modulate IP-10, Mig, and I-TAC in cultured human keratinocytes and CXCR3 expression in T cells from allergic contact dermatitis (ACD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mig; i-tac; cxcr3]
<Options>: A: c-x-c motif chemokine receptor 3 (homo sapiens) (aka c-x-c motif chemokine receptor 3)
B: tac1 (homo sapiens) (aka tachykinin precursor 1)
C: mig-6 (mus musculus) (aka erbb receptor feedback inhibitor 1)
D: 6ckine (homo sapiens) (aka c-c motif chemokine ligand 21)
E: c-x-c motif chemokine receptor 3 (xenopus tropicalis) (aka c-x-c motif chemokine receptor 3)
F: mig1 (homo sapiens) (aka vacuolar protein sorting 4 homolog b)
G: mig (homo sapiens) (aka c-x-c motif chemokine ligand 9)
H: mig (mus musculus) (aka c-x-c motif chemokine ligand 9)
I: ik cytokine (homo sapiens) (aka ik cytokine)
J: i-tac (mus musculus) (aka chemokine (c-x-c motif) ligand 11)
K: mig-6 (homo sapiens) (aka erbb receptor feedback inhibitor 1)
L: i-tac (homo sapiens) (aka c-x-c motif chemokine ligand 11)
M: cc-ckr-9 (homo sapiens) (aka c-c motif chemokine receptor 9)
N: c-c chemokine receptor type 3 (xenopus tropicalis) (aka c-c chemokine receptor type 3)
O: rxfpr3 (homo sapiens) (aka relaxin family peptide receptor 3)
P: None of the above. | [G; L; A] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: il-17a (homo sapiens) (aka interleukin 17a)
B: il-10c (homo sapiens) (aka interleukin 19)
C: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
D: interferon gamma (homo sapiens) (aka interferon gamma)
E: il-10a (homo sapiens) (aka interleukin 10)
F: il-4 (homo sapiens) (aka interleukin 4)
G: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
H: interferon gamma (sus scrofa) (aka interferon gamma)
I: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
J: il-17 (bos taurus) (aka interleukin 17a)
K: interferon gamma (gallus gallus) (aka interferon gamma)
L: bolf1 (human gammaherpesvirus 4) (aka tegument protein ul37)
M: ifn-gamma (gallus gallus) (aka interferon)
N: il-10 (oryctolagus cuniculus) (aka interleukin 10)
O: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
P: il-17f (homo sapiens) (aka interleukin 17f)
Q: il-17c (homo sapiens) (aka interleukin 17c)
R: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
S: interleukin 5 (homo sapiens) (aka interleukin 5)
T: None of the above. | [F; E; A; D] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
B: interferon gamma (xenopus tropicalis) (aka interferon gamma)
C: interleukin 17f (homo sapiens) (aka interleukin 17f)
D: il10 (homo sapiens) (aka interleukin 10)
E: il4 (homo sapiens) (aka interleukin 4)
F: interferon gamma (homo sapiens) (aka interferon gamma)
G: interleukin 5 (homo sapiens) (aka interleukin 5)
H: il-17 (homo sapiens) (aka interleukin 17a)
I: interferon gamma (gallus gallus) (aka interferon gamma)
J: il-17 (bos taurus) (aka interleukin 17a)
K: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
L: interleukin 17c (homo sapiens) (aka interleukin 17c)
M: interferon gamma (mus musculus) (aka interferon gamma)
N: il-10c (homo sapiens) (aka interleukin 19)
O: il-4 (bos taurus) (aka interleukin 4)
P: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
Q: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
R: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
S: interleukin 10 (bos taurus) (aka interleukin 10)
T: None of the above. | [E; D; H; F] |
<Instruct>: Given the context 'IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha-induced IP-10, Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [il-4; il-10; il-17; ifn-gamma]
<Options>: A: il4 (bos taurus) (aka interleukin 4)
B: il-17f (homo sapiens) (aka interleukin 17f)
C: interferon gamma (oryctolagus cuniculus) (aka interferon gamma)
D: interferon gamma (gallus gallus) (aka interferon gamma)
E: interferon gamma (homo sapiens) (aka interferon gamma)
F: il-4 (homo sapiens) (aka interleukin 4)
G: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
H: il-10c (homo sapiens) (aka interleukin 19)
I: il-17c (homo sapiens) (aka interleukin 17c)
J: bdlf4 (human gammaherpesvirus 4) (aka protein ul92)
K: interleukin 10 (homo sapiens) (aka interleukin 10)
L: interleukin 5 (homo sapiens) (aka interleukin 5)
M: il-17 (bos taurus) (aka interleukin 17a)
N: il17a (homo sapiens) (interleukin 17a (homo sapiens)) (aka interleukin 17a)
O: bllf1 (human gammaherpesvirus 4) (aka glycoprotein 350)
P: interleukin-10 (human betaherpesvirus 5) (aka interleukin-10)
Q: gmf-gamma (homo sapiens) (aka glia maturation factor gamma)
R: interferon gamma (xenopus tropicalis) (aka interferon gamma)
S: interleukin 10 (bos taurus) (aka interleukin 10)
T: None of the above. | [F; K; N; E] |
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