instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kip2]
<Options>: A: cyclin dependent kinase inhibitor 2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
D: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
E: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kip2; p57kip2]
<Options>: A: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
B: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
E: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
F: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
G: cyclin dependent kinase inhibitor 2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
H: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
I: None of the above. | [C; C] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kip2; p57kip2]
<Options>: A: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
B: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
C: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
D: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
E: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
F: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
G: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
H: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
I: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'Human KIP2 is located at 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, marking it as a candidate tumor suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [kip2]
<Options>: A: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
B: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
C: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
D: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
E: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21cip1]
<Options>: A: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
E: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
F: None of the above. | [A] |
<Instruct>: Given the context 'The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p21cip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: p-cip1 (homo sapiens) (aka ras association domain family member 9)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 beta converting enzyme]
<Options>: A: casp1 (homo sapiens) (aka caspase 1)
B: casp-7 (homo sapiens) (aka caspase 7)
C: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
D: casp3 (homo sapiens) (aka caspase 3)
E: casp2 (homo sapiens) (aka caspase 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
B: tx (homo sapiens) (aka caspase 4)
C: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
D: caspase 7 (homo sapiens) (aka caspase 7)
E: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
F: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
G: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
H: casp3 (homo sapiens) (aka caspase 3)
I: casp2 (homo sapiens) (aka caspase 2)
J: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
K: tx (drosophila melanogaster) (aka taxi)
L: ich-3 (homo sapiens) (aka caspase 5)
M: txs (homo sapiens) (aka thromboxane a synthase 1)
N: None of the above. | [B; G; G] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: txl (homo sapiens) (aka thioredoxin like 1)
B: ice(rel)ii (homo sapiens) (aka caspase 4)
C: ich-3 (homo sapiens) (aka caspase 5)
D: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
E: tx (drosophila melanogaster) (aka taxi)
F: txs (homo sapiens) (aka thromboxane a synthase 1)
G: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
H: tx (homo sapiens) (aka caspase 4)
I: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
J: caspase 1 (homo sapiens) (aka caspase 1)
K: casp2 (homo sapiens) (aka caspase 2)
L: casp3 (homo sapiens) (aka caspase 3)
M: casp7 (homo sapiens) (aka caspase 7)
N: None of the above. | [H; J; J] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: txl (homo sapiens) (aka thioredoxin like 1)
B: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
C: casp2 (homo sapiens) (aka caspase 2)
D: caspase 1 (homo sapiens) (aka caspase 1)
E: tx (homo sapiens) (aka caspase 4)
F: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
G: txs (homo sapiens) (aka thromboxane a synthase 1)
H: ice(rel)iii (homo sapiens) (aka caspase 5)
I: casp16 (homo sapiens) (aka caspase 16, pseudogene)
J: casp3 (homo sapiens) (aka caspase 3)
K: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
L: ice(rel)ii (homo sapiens) (aka caspase 4)
M: casp7 (homo sapiens) (aka caspase 7)
N: tx1 (xenopus tropicalis) (aka mab-21-like 3)
O: None of the above. | [E; D; D] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
B: casp2 (homo sapiens) (aka caspase 2)
C: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
D: casp3 (homo sapiens) (aka caspase 3)
E: ice(rel)iii (homo sapiens) (aka caspase 5)
F: tx (homo sapiens) (aka caspase 4)
G: ice(rel)ii (homo sapiens) (aka caspase 4)
H: txl (homo sapiens) (aka thioredoxin like 1)
I: casp16 (homo sapiens) (aka caspase 16, pseudogene)
J: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
K: txs (homo sapiens) (aka thromboxane a synthase 1)
L: tx1 (xenopus tropicalis) (aka mab-21-like 3)
M: casp7 (homo sapiens) (aka caspase 7)
N: None of the above. | [F; N; N] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nedd-2; ich-1l]
<Options>: A: ich-1 (mus musculus) (aka caspase 2)
B: casp1 (homo sapiens) (aka caspase 1)
C: casp-8 (homo sapiens) (aka caspase 8)
D: ich-2 (homo sapiens) (aka caspase 4)
E: nedds (homo sapiens) (aka shq1, h/aca ribonucleoprotein assembly factor)
F: nedd3 (homo sapiens) (aka developmentally regulated gtp binding protein 1)
G: nedd7 (homo sapiens) (aka dnaj heat shock protein family (hsp40) member a1)
H: nedd-2 (homo sapiens) (aka caspase 2)
I: death regulator nedd2-like caspase (drosophila melanogaster) (aka death regulator nedd2-like caspase)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nedd-2; ich-1l]
<Options>: A: ich-3 (homo sapiens) (aka caspase 5)
B: nedd9 (homo sapiens) (aka neural precursor cell expressed, developmentally down-regulated 9)
C: nedd1 (homo sapiens) (aka nedd1 gamma-tubulin ring complex targeting factor)
D: nedd2 (homo sapiens) (aka caspase 2)
E: ich-2 (homo sapiens) (aka caspase 4)
F: ich-1 (mus musculus) (aka caspase 2)
G: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
H: nedd3 (homo sapiens) (aka developmentally regulated gtp binding protein 1)
I: death regulator nedd2-like caspase (drosophila melanogaster) (aka death regulator nedd2-like caspase)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
B: txl (homo sapiens) (aka thioredoxin like 1)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: tx (homo sapiens) (aka caspase 4)
E: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
F: ich-3 (homo sapiens) (aka caspase 5)
G: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
H: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
I: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
J: casp16 (homo sapiens) (aka caspase 16, pseudogene)
K: None of the above. | [D; C] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
B: tx (homo sapiens) (aka caspase 4)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
E: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
F: ich-2 (homo sapiens) (aka caspase 4)
G: txl (homo sapiens) (aka thioredoxin like 1)
H: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
I: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
J: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
K: None of the above. | [B; E] |
<Instruct>: Given the context 'This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx]
<Options>: A: tx1 (xenopus tropicalis) (aka mab-21-like 3)
B: txl (homo sapiens) (aka thioredoxin like 1)
C: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
D: tx (homo sapiens) (aka caspase 4)
E: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
F: None of the above. | [D] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: ifnb1 (homo sapiens) (aka interferon beta 1)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
D: ice(rel)ii (homo sapiens) (aka caspase 4)
E: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
F: ich-3 (homo sapiens) (aka caspase 5)
G: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
H: il-1h (homo sapiens) (aka interleukin 37)
I: casp16 (homo sapiens) (aka caspase 16, pseudogene)
J: tx (drosophila melanogaster) (aka taxi)
K: tx1 (xenopus tropicalis) (aka mab-21-like 3)
L: tx (homo sapiens) (aka caspase 4)
M: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
N: il1beta (homo sapiens) (aka interleukin 1 beta)
O: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
P: il-1a (homo sapiens) (aka interleukin 1 alpha)
Q: None of the above. | [L; O; N; N] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
D: il-1h (homo sapiens) (aka interleukin 37)
E: txl (homo sapiens) (aka thioredoxin like 1)
F: ich-3 (homo sapiens) (aka caspase 5)
G: tx (homo sapiens) (aka caspase 4)
H: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
I: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
J: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
K: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
L: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
M: ich-2 (homo sapiens) (aka caspase 4)
N: il-1 (homo sapiens) (aka interleukin 1 beta)
O: il-1a (homo sapiens) (aka interleukin 1 alpha)
P: None of the above. | [G; I; N; N] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
B: tx (homo sapiens) (aka caspase 4)
C: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
D: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
E: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
F: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
G: txs (homo sapiens) (aka thromboxane a synthase 1)
H: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
I: interleukin 1 beta (homo sapiens) (aka interleukin 1 beta)
J: pseudo-ice (homo sapiens) (caspase recruitment domain family member 16 (homo sapiens)) (aka caspase recruitment domain family member 16)
K: il-1a (homo sapiens) (aka interleukin 1 alpha)
L: il-1h (homo sapiens) (aka interleukin 37)
M: interferon beta 1 (homo sapiens) (aka interferon beta 1)
N: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
O: casp16 (homo sapiens) (aka caspase 16, pseudogene)
P: None of the above. | [B; F; I; I] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: ifnb (homo sapiens) (aka interferon beta 1)
D: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
E: tx1 (xenopus tropicalis) (aka mab-21-like 3)
F: ice(rel)iii (homo sapiens) (aka caspase 5)
G: tx (homo sapiens) (aka caspase 4)
H: txs (homo sapiens) (aka thromboxane a synthase 1)
I: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
J: interleukin 1 beta (homo sapiens) (aka interleukin 1 beta)
K: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
L: il-1a (homo sapiens) (aka interleukin 1 alpha)
M: il-1h (homo sapiens) (aka interleukin 37)
N: ifnb1 (homo sapiens) (aka interferon beta 1)
O: casp16 (homo sapiens) (aka caspase 16, pseudogene)
P: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
Q: None of the above. | [G; P; J; J] |
<Instruct>: Given the context 'TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx]
<Options>: A: txs (homo sapiens) (aka thromboxane a synthase 1)
B: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
C: tx (homo sapiens) (aka caspase 4)
D: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
E: tx (drosophila melanogaster) (aka taxi)
F: None of the above. | [C] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: es18 (homo sapiens) (aka programmed cell death 7)
B: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
C: tnf receptor superfamily member 6b (homo sapiens) (aka tnf receptor superfamily member 6b)
D: lymphocyte antigen 96 (homo sapiens) (aka lymphocyte antigen 96)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
G: slam family member 6 (homo sapiens) (aka slam family member 6)
H: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
I: el18 (homo sapiens) (aka ribosomal protein l18)
J: itgb6 (homo sapiens) (aka integrin subunit beta 6)
K: None of the above. | [E; K] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
C: cd6 molecule (homo sapiens) (aka cd6 molecule)
D: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
E: tnf receptor superfamily member 6b (homo sapiens) (aka tnf receptor superfamily member 6b)
F: itgb6 (homo sapiens) (aka integrin subunit beta 6)
G: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
H: thy-1 cell surface antigen (homo sapiens) (aka thy-1 cell surface antigen)
I: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
J: es18 (homo sapiens) (aka programmed cell death 7)
K: None of the above. | [G; K] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: itgb6 (homo sapiens) (aka integrin subunit beta 6)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: cd6 molecule (homo sapiens) (aka cd6 molecule)
D: thy-1 cell surface antigen (homo sapiens) (aka thy-1 cell surface antigen)
E: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
F: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
G: el18 (homo sapiens) (aka ribosomal protein l18)
H: es18 (homo sapiens) (aka programmed cell death 7)
I: tnf receptor superfamily member 6b (homo sapiens) (aka tnf receptor superfamily member 6b)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: dgpx4 (drosophila melanogaster) (aka glutathione peroxidase homolog with thioredoxin peroxidase activity)
B: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
C: dgt4 (homo sapiens) (aka haus augmin like complex subunit 8)
D: dg6 (homo sapiens) (aka progesterone receptor membrane component 2)
E: desmocollin 3 (homo sapiens) (aka desmocollin 3)
F: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
G: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
H: dgk-4 (caenorhabditis elegans) (aka diacylglycerol kinase)
I: desmoglein 4 (homo sapiens) (aka desmoglein 4)
J: desmoglein 3 (homo sapiens) (aka desmoglein 3)
K: el18 (homo sapiens) (aka ribosomal protein l18)
L: desmoglein 3 (mus musculus) (aka desmoglein 3)
M: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
N: desmoglein 2 (homo sapiens) (aka desmoglein 2)
O: dgt4 (drosophila melanogaster) (aka dim gamma-tubulin 4)
P: None of the above. | [M; J; J] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: dgt4 (homo sapiens) (aka haus augmin like complex subunit 8)
C: desmoglein 3 (bos taurus) (aka desmoglein 3)
D: es18 (homo sapiens) (aka programmed cell death 7)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
G: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
H: desmoglein 4 (homo sapiens) (aka desmoglein 4)
I: mddgc4 (homo sapiens) (aka fukutin)
J: dg6 (homo sapiens) (aka progesterone receptor membrane component 2)
K: desmoglein 3 (mus musculus) (aka desmoglein 3)
L: dgpx4 (drosophila melanogaster) (aka glutathione peroxidase homolog with thioredoxin peroxidase activity)
M: dgs-h (homo sapiens) (aka ess-2 spliceosome associated protein)
N: desmoglein 3 (sus scrofa) (aka desmoglein 3)
O: desmoglein 3 (homo sapiens) (aka desmoglein 3)
P: None of the above. | [E; O; O] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
B: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
C: dgpx4 (drosophila melanogaster) (aka glutathione peroxidase homolog with thioredoxin peroxidase activity)
D: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
E: dgk-4 (caenorhabditis elegans) (aka diacylglycerol kinase)
F: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
G: dg6 (homo sapiens) (aka progesterone receptor membrane component 2)
H: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
I: desmoglein 2 (homo sapiens) (aka desmoglein 2)
J: dg2/dg3 (homo sapiens) (aka desmocollin 1)
K: dsc3 (homo sapiens) (desmocollin 3 (homo sapiens)) (aka desmocollin 3)
L: cdgs4 (homo sapiens) (aka alg3 alpha-1,3- mannosyltransferase)
M: desmoglein 1 (homo sapiens) (aka desmoglein 1)
N: dsg3 (homo sapiens) (aka desmoglein 3)
O: desmoglein 3 (mus musculus) (aka desmoglein 3)
P: None of the above. | [F; N; N] |
<Instruct>: Given the context 'A cDNA clone encoding the E48 antigen was isolated by expression cloning in COS cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
B: e47 (homo sapiens) (aka transcription factor 3)
C: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
D: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | [E] |
<Instruct>: Given the context 'A cDNA clone encoding the E48 antigen was isolated by expression cloning in COS cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: e47 (homo sapiens) (aka transcription factor 3)
B: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
C: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
D: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
E: None of the above. | [E] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; thb]
<Options>: A: thbs (homo sapiens) (aka thrombospondin 1)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
D: thbs (bos taurus) (aka thrombospondin 1)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
G: thbd (bos taurus) (aka thrombomodulin)
H: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
I: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
J: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
K: None of the above. | [E; F] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen; thb]
<Options>: A: thbd (bos taurus) (aka thrombomodulin)
B: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
C: es18 (homo sapiens) (aka programmed cell death 7)
D: thbs (bos taurus) (aka thrombospondin 1)
E: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
F: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
G: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
H: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
I: thbs (homo sapiens) (aka thrombospondin 1)
J: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
K: None of the above. | [G; J] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: phosphatidylinositol phospholipase c (saccharomyces cerevisiae s288c) (aka phosphatidylinositol phospholipase c)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: plc-ii (homo sapiens) (aka phospholipase c gamma 1)
D: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
E: plcl3 (homo sapiens) (aka phospholipase c eta 1)
F: phosphatidylinositol-specific phospholipase c (glycine max) (aka phosphatidylinositol-specific phospholipase c)
G: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
H: phosphatidylinositol phospholipase c (candida albicans sc5314) (aka phosphatidylinositol phospholipase c)
I: el18 (homo sapiens) (aka ribosomal protein l18)
J: es18 (homo sapiens) (aka programmed cell death 7)
K: None of the above. | [C; B] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: phosphatidylinositol phospholipase c (candida albicans sc5314) (aka phosphatidylinositol phospholipase c)
B: plc-iii (homo sapiens) (aka phospholipase c delta 1)
C: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
D: plc-ii (homo sapiens) (aka phospholipase c gamma 1)
E: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
F: tegument protein g48 (human gammaherpesvirus 4) (aka tegument protein g48)
G: es18 (homo sapiens) (aka programmed cell death 7)
H: plc-i (homo sapiens) (aka phospholipase c beta 1)
I: plcl3 (homo sapiens) (aka phospholipase c eta 1)
J: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
K: None of the above. | [D; J] |
<Instruct>: Given the context 'The gene encoding the E48 antigen is a single copy gene, located on human chromosome 8 in the 8q24-qter region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
E: e47 (homo sapiens) (aka transcription factor 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'The putative mouse homologue, the ThB antigen, originally identified as an antigen on cells of the lymphocyte lineage, was shown to be highly expressed in squamous mouse epithelia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thb]
<Options>: A: htnb (homo sapiens) (aka phosphodiesterase 3a)
B: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
C: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
D: thbgb (homo sapiens) (aka pro-platelet basic protein)
E: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
F: None of the above. | [E] |
<Instruct>: Given the context 'The putative mouse homologue, the ThB antigen, originally identified as an antigen on cells of the lymphocyte lineage, was shown to be highly expressed in squamous mouse epithelia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thb]
<Options>: A: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
B: thbgb (homo sapiens) (aka pro-platelet basic protein)
C: htnb (homo sapiens) (aka phosphodiesterase 3a)
D: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
E: None of the above. | [E] |
<Instruct>: Given the context 'Moreover, the ThB expression level is in keratinocytes, in contrast to that in lymphocytes, not mouse strain related.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thb]
<Options>: A: thbs (homo sapiens) (aka thrombospondin 1)
B: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
C: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
D: t cell receptor beta locus (homo sapiens) (aka t cell receptor beta locus)
E: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
F: None of the above. | [B] |
<Instruct>: Given the context 'Transfection of mouse SV40-polyoma transformed mouse NIH/3T3 cells with the E48 cDNA confirmed that the antigen is likely to be involved in cell-cell adhesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48]
<Options>: A: e47 (homo sapiens) (aka transcription factor 3)
B: e4bp4 (homo sapiens) (aka nuclear factor, interleukin 3 regulated)
C: e46l (homo sapiens) (aka ataxin 10)
D: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
E: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
F: None of the above. | [D] |
<Instruct>: Given the context 'Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [peroxisomal targeting signal-1 receptor]
<Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: peroxisomal biogenesis factor 1 (homo sapiens) (aka peroxisomal biogenesis factor 1)
C: sphingosine-1-phosphate receptor 1 (xenopus tropicalis) (aka sphingosine-1-phosphate receptor 1)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pasp (homo sapiens) (aka carboxypeptidase b1)
D: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
E: bhlha8 (homo sapiens) (aka neurogenin 2)
F: pasd6 (homo sapiens) (aka neuronal pas domain protein 3)
G: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
H: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
I: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
J: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
K: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
L: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
M: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
N: None of the above. | [H; K; H] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
B: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
C: pts1 (glycine max) (aka pterocarpan synthase)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: bhlha8 (homo sapiens) (aka neurogenin 2)
F: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
G: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
H: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
I: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
J: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
K: pas-3 (homo sapiens) (aka glycophorin b (mns blood group))
L: pasd5 (homo sapiens) (aka neuronal pas domain protein 1)
M: None of the above. | [G; B; G] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pasd5 (homo sapiens) (aka neuronal pas domain protein 1)
F: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
G: pts1 (glycine max) (aka pterocarpan synthase)
H: pex5r (xenopus tropicalis) (aka peroxisomal biogenesis factor 5-like)
I: pasp (homo sapiens) (aka carboxypeptidase b1)
J: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
K: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
L: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
M: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
N: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
O: None of the above. | [D; N; D] |
<Instruct>: Given the context 'The PTS1R mRNA is expressed in all human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
E: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: None of the above. | [E] |
<Instruct>: Given the context 'Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
F: None of the above. | [D] |
<Instruct>: Given the context 'Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
C: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
F: None of the above. | [D] |
<Instruct>: Given the context 'Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts1 (glycine max) (aka pterocarpan synthase)
D: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | [D] |
<Instruct>: Given the context 'In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
E: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
F: None of the above. | [B] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pas-3 (homo sapiens) (aka glycophorin b (mns blood group))
C: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
D: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
E: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: pas8 (mus musculus) (aka pulmonary adenoma susceptibility 8)
G: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
H: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
I: pasp (homo sapiens) (aka carboxypeptidase b1)
J: pts1 (glycine max) (aka pterocarpan synthase)
K: None of the above. | [H; E] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: pas8 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 6)
E: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
F: pasd6 (homo sapiens) (aka neuronal pas domain protein 3)
G: pasd8 (homo sapiens) (aka hypoxia inducible factor 1 subunit alpha)
H: bhlha8 (homo sapiens) (aka neurogenin 2)
I: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
J: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pas domain protein 4)
K: None of the above. | [D; B] |
<Instruct>: Given the context 'The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
B: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1 (glycine max) (aka pterocarpan synthase)
E: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
F: None of the above. | [E] |
<Instruct>: Given the context 'The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts1 (glycine max) (aka pterocarpan synthase)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
F: None of the above. | [D] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
B: ntf3 (xenopus laevis) (neurotrophin 3 l homeolog (xenopus laevis)) (aka neurotrophin 3 l homeolog)
C: neurotrophin 3 (homo sapiens) (aka neurotrophin 3)
D: ntrk4 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 1)
E: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
F: ntf3 (xenopus laevis) (neurotrophin 3 s homeolog (xenopus laevis)) (aka neurotrophin 3 s homeolog)
G: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
H: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
I: ntr3 (homo sapiens) (aka sortilin 1)
J: neurotrophin 3 (xenopus tropicalis) (aka neurotrophin 3)
K: ntn3 (homo sapiens) (aka netrin 3)
L: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
M: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
N: None of the above. | [G; G; C] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: ntf3 (xenopus laevis) (neurotrophin 3 s homeolog (xenopus laevis)) (aka neurotrophin 3 s homeolog)
B: ntr3 (homo sapiens) (aka sortilin 1)
C: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
D: ntf3 (xenopus laevis) (neurotrophin 3 l homeolog (xenopus laevis)) (aka neurotrophin 3 l homeolog)
E: ntf3 (homo sapiens) (aka neurotrophin 3)
F: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
G: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
H: neurotrophin 3 (xenopus tropicalis) (aka neurotrophin 3)
I: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
J: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
K: ntrk3 (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
L: ntn3 (homo sapiens) (aka netrin 3)
M: None of the above. | [C; C; E] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: nt-3 (homo sapiens) (aka neurotrophin 3)
B: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
C: neurotrophin 3 (xenopus tropicalis) (aka neurotrophin 3)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
E: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
G: neurotrophin-3 (gallus gallus) (aka neurotrophin 3)
H: ntrk3 (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
I: ntf3 (xenopus laevis) (neurotrophin 3 s homeolog (xenopus laevis)) (aka neurotrophin 3 s homeolog)
J: ntr3 (homo sapiens) (aka sortilin 1)
K: ntf3 (xenopus laevis) (neurotrophin 3 l homeolog (xenopus laevis)) (aka neurotrophin 3 l homeolog)
L: ntrk4 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 1)
M: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
N: None of the above. | [B; B; A] |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
E: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'The rat trkC has several isoforms due to alternative splicing in the tyrosine kinase domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
E: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'The human trkC cDNA also has a (CGG)n repeat in the 5'-untranslated region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trkb (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
B: ntrk3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
E: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'By PCR analysis of a somatic cell hybrid panel and fluorescence in situ hybridization with the cDNA clone, human trkC was mapped to chromosome 15q24-q25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
B: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
C: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
D: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
E: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2; fbln2]
<Options>: A: fbln2 (sus scrofa) (aka fibulin 2)
B: fbln2 (homo sapiens) (aka fibulin 2)
C: fbn2 (homo sapiens) (aka fibrillin 2)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: fibulin 1 (homo sapiens) (aka fibulin 1)
F: fibulin 2 (sus scrofa) (aka fibulin 2)
G: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
H: fbln1 (homo sapiens) (aka fibulin 1)
I: fbln4 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2; fbln2]
<Options>: A: fbln2 (sus scrofa) (aka fibulin 2)
B: fbln2 (homo sapiens) (aka fibulin 2)
C: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
D: fbn2 (homo sapiens) (aka fibrillin 2)
E: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
F: fbln1 (homo sapiens) (aka fibulin 1)
G: fibulin 1 (homo sapiens) (aka fibulin 1)
H: fibulin 5 (homo sapiens) (aka fibulin 5)
I: None of the above. | [B; B] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2; fbln2]
<Options>: A: fbln1 (homo sapiens) (aka fibulin 1)
B: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
C: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
D: fbn2 (homo sapiens) (aka fibrillin 2)
E: fibulin 5 (homo sapiens) (aka fibulin 5)
F: fibulin 1 (homo sapiens) (aka fibulin 1)
G: fbln2 (sus scrofa) (aka fibulin 2)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'Fibulin-2 mRNA is prominently expressed in mouse heart tissue and is present in low amounts in other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
B: fibulin 5 (homo sapiens) (aka fibulin 5)
C: fibulin 2 (homo sapiens) (aka fibulin 2)
D: fibulin 2 (sus scrofa) (aka fibulin 2)
E: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'In this study, we isolated and sequenced a 4.1-kb human fibulin-2 cDNA, which encoded a mature protein of 1157 amino acids preceded by a 27-residue signal sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: fibulin 2 (sus scrofa) (aka fibulin 2)
B: fibrillin 2 (homo sapiens) (aka fibrillin 2)
C: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
D: fibulin 2 (homo sapiens) (aka fibulin 2)
E: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'The 115-residue C-terminal segment (domain III) is similar to the C variant of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: fibulin 5 (homo sapiens) (aka fibulin 5)
D: fibulin 1 (homo sapiens) (aka fibulin 1)
E: fibin (homo sapiens) (aka fin bud initiation factor homolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: fibin (homo sapiens) (aka fin bud initiation factor homolog)
B: fibulin 2 (homo sapiens) (aka fibulin 2)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'The expression pattern differs from that of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: fibulin 1 (homo sapiens) (aka fibulin 1)
B: fibulin 2 (homo sapiens) (aka fibulin 2)
C: fibulin 5 (homo sapiens) (aka fibulin 5)
D: fibrillin 1 (homo sapiens) (aka fibrillin 1)
E: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'The fibulin-2 gene was localized by in situ hybridization to the p24-p25 region of human chromosome 3 and to the band D-E of mouse chromosome 6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
B: fibrillin 2 (homo sapiens) (aka fibrillin 2)
C: fibulin 2 (sus scrofa) (aka fibulin 2)
D: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
E: fibulin 2 (homo sapiens) (aka fibulin 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tar dna binding protein (bos taurus) (aka tar dna binding protein)
B: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
C: tata-binding protein (saccharomyces cerevisiae s288c) (aka tata-binding protein)
D: tbp-b (xenopus tropicalis) (aka tata-box binding protein)
E: tata-box binding protein like 1 (bos taurus) (aka tata-box binding protein like 1)
F: tbpa (homo sapiens) (aka transthyretin)
G: tata-box binding protein (bos taurus) (aka tata-box binding protein)
H: rbp (drosophila melanogaster) (tata binding protein (drosophila melanogaster)) (aka tata binding protein)
I: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
B: tata-binding protein (saccharomyces cerevisiae s288c) (aka tata-binding protein)
C: tar dna binding protein (bos taurus) (aka tar dna binding protein)
D: tbp-b (xenopus tropicalis) (aka tata-box binding protein)
E: tata-box binding protein (bos taurus) (aka tata-box binding protein)
F: tbpa (homo sapiens) (aka transthyretin)
G: tata-box binding protein like 1 (xenopus tropicalis) (aka tata-box binding protein like 1)
H: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
I: None of the above. | [A; A] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tbp protein-like pseudogene (bos taurus) (aka tbp protein-like pseudogene)
B: tar dna binding protein (bos taurus) (aka tar dna binding protein)
C: tbpa (homo sapiens) (aka transthyretin)
D: tata-binding protein (saccharomyces cerevisiae s288c) (aka tata-binding protein)
E: tata-box binding protein (bos taurus) (aka tata-box binding protein)
F: tata-box binding protein like 1 (xenopus tropicalis) (aka tata-box binding protein like 1)
G: tbp-b (xenopus tropicalis) (aka tata-box binding protein)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55]
<Options>: A: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
B: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
C: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
D: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
E: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)
F: None of the above. | [A] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: yy1 (homo sapiens) (aka yy1 transcription factor)
B: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
C: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
D: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
E: t-sp1 (homo sapiens) (aka serine protease 55)
F: yin-yang-1 (xenopus laevis) (yy1 transcription factor s homeolog (xenopus laevis)) (aka yy1 transcription factor s homeolog)
G: yy1 transcription factor (xenopus tropicalis) (aka yy1 transcription factor)
H: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
I: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)
J: taf3 (saccharomyces cerevisiae s288c) (aka taf3p)
K: yy1 (drosophila melanogaster) (aka pleiohomeotic)
L: sp1 (mus musculus) (aka trans-acting transcription factor 1)
M: sp1 (homo sapiens) (sp1 transcription factor (homo sapiens)) (aka sp1 transcription factor)
N: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
O: tafii30 (homo sapiens) (aka tata-box binding protein associated factor 10)
P: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
Q: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
R: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
S: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 1 (drosophila melanogaster)) (aka tbp-associated factor 1)
T: tafii250 (homo sapiens) (aka tata-box binding protein associated factor 1)
U: None of the above. | [D; T; M; A] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: yy1 (xenopus laevis) (yy1 transcription factor l homeolog (xenopus laevis)) (aka yy1 transcription factor l homeolog)
B: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
C: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
D: yy1 transcription factor (homo sapiens) (aka yy1 transcription factor)
E: sp1 transcription factor (xenopus tropicalis) (aka sp1 transcription factor)
F: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
G: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
H: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)
I: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
J: taf23 (saccharomyces cerevisiae s288c) (aka taf10p)
K: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
L: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 1 (drosophila melanogaster)) (aka tbp-associated factor 1)
M: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
N: sp1 (homo sapiens) (sp1 transcription factor (homo sapiens)) (aka sp1 transcription factor)
O: yy1 (xenopus tropicalis) (aka yy1 transcription factor)
P: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
Q: yy1 (drosophila melanogaster) (aka pleiohomeotic)
R: taf30 (saccharomyces cerevisiae s288c) (aka tata-binding protein-associated factor taf14)
S: tafii-250 (homo sapiens) (aka tata-box binding protein associated factor 1)
T: sp1 (mus musculus) (aka trans-acting transcription factor 1)
U: None of the above. | [F; S; N; D] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: yin-yang-1 (xenopus laevis) (yy1 transcription factor s homeolog (xenopus laevis)) (aka yy1 transcription factor s homeolog)
B: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
C: yy1 (xenopus tropicalis) (aka yy1 transcription factor)
D: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
E: yy1 (drosophila melanogaster) (aka pleiohomeotic)
F: taf3 (saccharomyces cerevisiae s288c) (aka taf3p)
G: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
H: yy1 transcription factor (homo sapiens) (aka yy1 transcription factor)
I: h-sp1 (homo sapiens) (aka synaptophysin like 1)
J: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
K: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 1 (drosophila melanogaster)) (aka tbp-associated factor 1)
L: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
M: tafii30 (homo sapiens) (aka tata-box binding protein associated factor 10)
N: sp1 transcription factor (xenopus tropicalis) (aka sp1 transcription factor)
O: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
P: t-sp1 (homo sapiens) (aka serine protease 55)
Q: tafii-250 (homo sapiens) (aka tata-box binding protein associated factor 1)
R: sp1 (mus musculus) (aka trans-acting transcription factor 1)
S: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
T: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
U: None of the above. | [G; Q; O; H] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
B: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
C: tafii-250 (homo sapiens) (aka tata-box binding protein associated factor 1)
D: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
E: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
F: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
G: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
H: yin-yang-1 (xenopus laevis) (yy1 transcription factor s homeolog (xenopus laevis)) (aka yy1 transcription factor s homeolog)
I: taf3 (saccharomyces cerevisiae s288c) (aka taf3p)
J: t-sp1 (homo sapiens) (aka serine protease 55)
K: yy1 (xenopus laevis) (yy1 transcription factor l homeolog (xenopus laevis)) (aka yy1 transcription factor l homeolog)
L: yy1 (xenopus tropicalis) (aka yy1 transcription factor)
M: yin-yang-1 (homo sapiens) (aka yy1 transcription factor)
N: taf[[ii]] (drosophila melanogaster) (tbp-associated factor 5 (drosophila melanogaster)) (aka tbp-associated factor 5)
O: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
P: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
Q: taf30 (saccharomyces cerevisiae s288c) (aka tata-binding protein-associated factor taf14)
R: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
S: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 1 (drosophila melanogaster)) (aka tbp-associated factor 1)
T: sp1 (mus musculus) (aka trans-acting transcription factor 1)
U: None of the above. | [D; C; R; M] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [usf]
<Options>: A: protein usf-like (glycine max) (aka protein usf-like)
B: usf1 (homo sapiens) (aka upstream transcription factor 1)
C: usf3 (homo sapiens) (aka upstream transcription factor family member 3)
D: usf1p (homo sapiens) (aka upstream transcription factor 1 pseudogene 1)
E: usf1 (xenopus tropicalis) (aka upstream transcription factor 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii100 (homo sapiens) (aka tata-box binding protein associated factor 5)
B: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
C: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
D: tafii140 (homo sapiens) (aka tata-box binding protein associated factor 3)
E: tafii130 (homo sapiens) (aka tata-box binding protein associated factor 4)
F: sp1 transcription factor (xenopus tropicalis) (aka sp1 transcription factor)
G: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
H: sp1 (homo sapiens) (sp1 transcription factor (homo sapiens)) (aka sp1 transcription factor)
I: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
J: taf5 (saccharomyces cerevisiae s288c) (aka chromatin modification protein)
K: h-sp1 (homo sapiens) (aka synaptophysin like 1)
L: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
M: taf65 (saccharomyces cerevisiae s288c) (aka taf8p)
N: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
O: taf30 (saccharomyces cerevisiae s288c) (aka tata-binding protein-associated factor taf14)
P: None of the above. | [I; H; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: taf30 (saccharomyces cerevisiae s288c) (aka tata-binding protein-associated factor taf14)
B: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
C: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
D: taf2 (saccharomyces cerevisiae s288c) (aka transcription initiation factor tfiid subunit taf2)
E: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
F: sp1 (xenopus tropicalis) (sp1 transcription factor (xenopus tropicalis)) (aka sp1 transcription factor)
G: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
H: tafii100 (homo sapiens) (aka tata-box binding protein associated factor 5)
I: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
J: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
K: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
L: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
M: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
N: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
O: tafii70 (homo sapiens) (aka tata-box binding protein associated factor 6)
P: None of the above. | [G; B; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: taf10 (saccharomyces cerevisiae s288c) (aka taf10p)
B: sp1 (mus musculus) (aka trans-acting transcription factor 1)
C: tafii-140 (homo sapiens) (aka tata-box binding protein associated factor 3)
D: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
E: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
F: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)
G: tafii70 (homo sapiens) (aka tata-box binding protein associated factor 6)
H: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
I: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
J: sp1 transcription factor (bos taurus) (aka sp1 transcription factor)
K: sp1 transcription factor (homo sapiens) (aka sp1 transcription factor)
L: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
M: tafii-130 (homo sapiens) (aka tata-box binding protein associated factor 4)
N: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
O: tafii-32 (homo sapiens) (aka tata-box binding protein associated factor 9)
P: None of the above. | [H; K; P] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ergic-53; mr60]
<Options>: A: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
B: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
C: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
D: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
E: ro60 (homo sapiens) (aka ro60, y rna binding protein)
F: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
G: ergic-53 (homo sapiens) (aka lectin, mannose binding 1)
H: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
I: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
J: None of the above. | [G; G] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ergic-53; mr60]
<Options>: A: hel60 (homo sapiens) (aka aconitase 1)
B: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
C: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
D: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
E: ergic3 (homo sapiens) (aka ergic and golgi 3)
F: ergic-53l (mus musculus) (aka complexin 3)
G: ergic53 (drosophila melanogaster) (aka ergic53)
H: ro60 (homo sapiens) (aka ro60, y rna binding protein)
I: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'A mannose-specific membrane lectin (MR60) isolated from human myelomonocytic HL60 cells by affinity chromatography is expressed in intracellular organelles of immature monocytes (Pimpaneau, V., Midoux, P., Monsigny, M., and Roche, A. C. (1991) Carbohydr.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60]
<Options>: A: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
B: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
C: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
D: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
E: mr60 (homo sapiens) (aka lectin, mannose binding 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'It is not present at the cell surface and is immunochemically and structurally distinct from the M(r) 175,000 mannose receptor of mature macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [m(r) 175,000 mannose receptor of mature macrophages]
<Options>: A: mannose receptor c-type 1 (homo sapiens) (aka mannose receptor c-type 1)
B: mannose receptor, c type 1 (mus musculus) (aka mannose receptor, c type 1)
C: macrophage receptor with collagenous structure (mus musculus) (aka macrophage receptor with collagenous structure)
D: mannose receptor, c type 2 (mus musculus) (aka mannose receptor, c type 2)
E: mannose receptor c-type 2 (homo sapiens) (aka mannose receptor c-type 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'MR60 cDNA was isolated and characterized; on the basis of its sequence, MR60 is not related to any known mammalian lectins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60]
<Options>: A: hel60 (homo sapiens) (aka aconitase 1)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
D: ro60 (homo sapiens) (aka ro60, y rna binding protein)
E: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: mr60 (homo sapiens) (aka lectin, mannose binding 1)
B: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
C: ergic3 (homo sapiens) (aka ergic and golgi 3)
D: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
E: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
F: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
G: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
H: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
I: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: ergic-53l (mus musculus) (aka complexin 3)
C: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
D: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
E: ro60 (homo sapiens) (aka ro60, y rna binding protein)
F: mr60 (homo sapiens) (aka lectin, mannose binding 1)
G: ergic3 (homo sapiens) (aka ergic and golgi 3)
H: hel60 (homo sapiens) (aka aconitase 1)
I: ergic53 (drosophila melanogaster) (aka ergic53)
J: None of the above. | [F; F] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: vip32 (xenopus tropicalis) (aka arginine vasopressin induced 1)
B: vacuolar protein sorting 36 homolog (xenopus tropicalis) (aka vacuolar protein sorting 36 homolog)
C: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
D: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
E: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
F: vip36 (xenopus laevis) (lectin, mannose-binding 2 s homeolog (xenopus laevis)) (aka lectin, mannose-binding 2 s homeolog)
G: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
H: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
I: mr60 (homo sapiens) (aka lectin, mannose binding 1)
J: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
K: ergic3 (homo sapiens) (aka ergic and golgi 3)
L: vip36 (mus musculus) (aka lectin, mannose-binding 2)
M: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
N: vip36 (homo sapiens) (aka lectin, mannose binding 2)
O: None of the above. | [I; I; N] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
B: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
C: icen-36 (homo sapiens) (aka centromere protein o)
D: vacuolar protein sorting 36 homolog (xenopus tropicalis) (aka vacuolar protein sorting 36 homolog)
E: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
F: vip36 (homo sapiens) (aka lectin, mannose binding 2)
G: mr60 (homo sapiens) (aka lectin, mannose binding 1)
H: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
I: vip32 (homo sapiens) (aka arginine vasopressin induced 1)
J: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
K: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
L: ergic-53l (mus musculus) (aka complexin 3)
M: vip36 (xenopus laevis) (lectin, mannose-binding 2 s homeolog (xenopus laevis)) (aka lectin, mannose-binding 2 s homeolog)
N: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
O: None of the above. | [G; G; F] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: mr60 (homo sapiens) (aka lectin, mannose binding 1)
B: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
C: vip32 (xenopus tropicalis) (aka arginine vasopressin induced 1)
D: ergic53 (drosophila melanogaster) (aka ergic53)
E: hel60 (homo sapiens) (aka aconitase 1)
F: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
G: vacuolar protein sorting 36 homolog (xenopus tropicalis) (aka vacuolar protein sorting 36 homolog)
H: vip36 (rattus norvegicus) (aka lectin, mannose-binding 2)
I: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
J: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
K: vip36 (homo sapiens) (aka lectin, mannose binding 2)
L: ergic3 (homo sapiens) (aka ergic and golgi 3)
M: vip36 (xenopus laevis) (lectin, mannose-binding 2 s homeolog (xenopus laevis)) (aka lectin, mannose-binding 2 s homeolog)
N: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
O: None of the above. | [A; A; K] |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: ro60 (homo sapiens) (aka ro60, y rna binding protein)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
D: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
E: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
F: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
G: ergic-53l (mus musculus) (aka complexin 3)
H: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
I: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
J: None of the above. | [B; B] |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
B: hel60 (homo sapiens) (aka aconitase 1)
C: ergic53 (drosophila melanogaster) (aka ergic53)
D: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
E: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
F: mic60 (homo sapiens) (aka inner membrane mitochondrial protein)
G: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
H: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
I: mr60 (homo sapiens) (aka lectin, mannose binding 1)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
C: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
D: ergic53 (drosophila melanogaster) (aka ergic53)
E: hel60 (homo sapiens) (aka aconitase 1)
F: mr60 (homo sapiens) (aka lectin, mannose binding 1)
G: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
H: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
I: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: mr60 (homo sapiens) (aka lectin, mannose binding 1)
B: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
C: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
D: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
E: ergic-53l (mus musculus) (aka complexin 3)
F: ro60 (homo sapiens) (aka ro60, y rna binding protein)
G: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
H: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
I: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
J: None of the above. | [A; A] |
<Instruct>: Given the context 'Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 tumor necrosis factor receptor]
<Options>: A: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfrsf1a (homo sapiens) (aka tnf receptor superfamily member 1a)
C: tnf receptor superfamily member 1b (homo sapiens) (aka tnf receptor superfamily member 1b)
D: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
E: None of the above. | [B] |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 receptor for tumor necrosis factor; tnfr-1ic]
<Options>: A: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
B: tnfr3 (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
D: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
E: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
F: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
G: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
H: None of the above. | [G; G] |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 receptor for tumor necrosis factor; tnfr-1ic]
<Options>: A: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
D: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
E: tnf-r (homo sapiens) (aka tnf receptor superfamily member 1a)
F: tnf-r-iii (homo sapiens) (aka lymphotoxin beta receptor)
G: None of the above. | [E; E] |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 receptor for tumor necrosis factor; tnfr-1ic]
<Options>: A: tnf-r-iii (homo sapiens) (aka lymphotoxin beta receptor)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
E: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
F: None of the above. | [F; F] |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf receptor-associated protein; trap-1]
<Options>: A: tnf receptor associated factor 6 (homo sapiens) (aka tnf receptor associated factor 6)
B: tnf receptor associated factor 7 (homo sapiens) (aka tnf receptor associated factor 7)
C: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
D: trap100 (homo sapiens) (aka mediator complex subunit 24)
E: tnf receptor associated factor 1 (homo sapiens) (aka tnf receptor associated factor 1)
F: tnf receptor associated factor (traf) homolog (caenorhabditis elegans) (aka tnf receptor associated factor (traf) homolog)
G: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
H: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
I: tnf receptor associated factor 5 (homo sapiens) (aka tnf receptor associated factor 5)
J: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnf receptor-associated protein; trap-1]
<Options>: A: tnf receptor associated factor (traf) homolog (caenorhabditis elegans) (aka tnf receptor associated factor (traf) homolog)
B: tnf receptor associated factor 5 (homo sapiens) (aka tnf receptor associated factor 5)
C: trap100 (homo sapiens) (aka mediator complex subunit 24)
D: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
E: trap1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
F: tnf receptor associated protein 1 (homo sapiens) (aka tnf receptor associated protein 1)
G: tnf receptor-associated protein 1 (xenopus tropicalis) (aka tnf receptor-associated protein 1)
H: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
I: tnf receptor associated factor 1 (homo sapiens) (aka tnf receptor associated factor 1)
J: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
K: None of the above. | [K; K] |
<Instruct>: Given the context 'After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trap-1; tnfr-1ic]
<Options>: A: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
B: tnf-r-iii (homo sapiens) (aka lymphotoxin beta receptor)
C: tnfar (homo sapiens) (aka tnf receptor superfamily member 1a)
D: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
E: trap100 (homo sapiens) (aka mediator complex subunit 24)
F: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
G: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
H: trap95 (homo sapiens) (aka mediator complex subunit 16)
I: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
J: None of the above. | [J; C] |
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