instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; eck]
<Options>: A: sla- (sus scrofa) (aka mhc class i antigen 1)
B: slap-2 (homo sapiens) (aka src like adaptor 2)
C: eek (homo sapiens) (aka eph receptor a8)
D: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
E: eck (homo sapiens) (aka eph receptor a2)
F: eck (mus musculus) (aka eph receptor a2)
G: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
H: cek (homo sapiens) (aka fibroblast growth factor receptor 1)
I: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
J: slan (homo sapiens) (aka secis binding protein 2 like)
K: None of the above. | [D; E] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; eck]
<Options>: A: eck (homo sapiens) (aka eph receptor a2)
B: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
C: cek7 (homo sapiens) (aka eph receptor a5)
D: slan (homo sapiens) (aka secis binding protein 2 like)
E: slat (homo sapiens) (aka def6 guanine nucleotide exchange factor)
F: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
G: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
H: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
I: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
J: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap]
<Options>: A: sla- (sus scrofa) (aka mhc class i antigen 1)
B: slan (homo sapiens) (aka secis binding protein 2 like)
C: slap-2 (homo sapiens) (aka src like adaptor 2)
D: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
E: sla1p (homo sapiens) (aka src like adaptor)
F: None of the above. | [E] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: cb1 (mus musculus) (aka cannabinoid receptor 1)
E: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
G: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
H: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
I: None of the above. | [B; F] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and spleen, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: cb1a (homo sapiens) (aka cannabinoid receptor 1)
F: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
G: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
H: cb2 (homo sapiens) (aka cannabinoid receptor 2)
I: None of the above. | [E; H] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1a (homo sapiens) (aka cannabinoid receptor 1)
D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
E: cb1r (mus musculus) (aka cannabinoid receptor 1)
F: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
G: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
H: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
I: None of the above. | [C; D] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cb1a (homo sapiens) (aka cannabinoid receptor 1)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: cb2 (homo sapiens) (aka cannabinoid receptor 2)
F: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
G: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
H: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
I: None of the above. | [B; E] |
<Instruct>: Given the context 'CB1 was mainly expressed in the central nervous system and, to a lower extent, in several peripheral tissues such as adrenal gland, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus and tonsils.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1]
<Options>: A: cb1r (homo sapiens) (aka cannabinoid receptor 1)
B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1r (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | [A] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cb2 (homo sapiens) (aka cannabinoid receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cb1a (mus musculus) (aka cannabinoid receptor 1)
F: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
G: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
H: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
I: None of the above. | [C; G] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cb1a (mus musculus) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
F: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
G: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
H: None of the above. | [H; B] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cb1a (homo sapiens) (aka cannabinoid receptor 1)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
E: cb2 (homo sapiens) (aka cannabinoid receptor 2)
F: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
G: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
H: cb1r (mus musculus) (aka cannabinoid receptor 1)
I: None of the above. | [E; A] |
<Instruct>: Given the context 'Although CB2 mRNA was also detected in some other peripheral tissues, its level remained very low.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cb1 (mus musculus) (aka cannabinoid receptor 1)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cb1r (homo sapiens) (aka cannabinoid receptor 1)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
F: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
G: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
H: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
I: None of the above. | [H; C] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: cb1a (homo sapiens) (aka cannabinoid receptor 1)
E: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
F: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
G: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
H: cb1 (mus musculus) (aka cannabinoid receptor 1)
I: None of the above. | [B; D] |
<Instruct>: Given the context 'Among the main human blood cell subpopulations, the distribution pattern of the CB2 mRNA displayed important variations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'The rank order of CB2 mRNA levels in these cells was B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
F: None of the above. | [D] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid follicles.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cb1a (mus musculus) (aka cannabinoid receptor 1)
D: cb2 (homo sapiens) (aka cannabinoid receptor 2)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
F: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
G: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
H: cb1r (homo sapiens) (aka cannabinoid receptor 1)
I: None of the above. | [H; D] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb1; cb2]
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb1a (homo sapiens) (aka cannabinoid receptor 1)
E: cb2 (homo sapiens) (aka cannabinoid receptor 2)
F: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
G: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
H: cb1a (mus musculus) (aka cannabinoid receptor 1)
I: None of the above. | [D; E] |
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: coagulation factor ii thrombin receptor like 2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
B: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like)
C: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
D: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
E: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
B: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2)
C: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
D: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3)
E: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'By fluorescence in situ hybridization, the human proteinase-activated receptor 2 gene was mapped to chromosomal region 5q13, where, previously, the related thrombin receptor gene has been located.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2rl2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
B: prokr2 (homo sapiens) (aka prokineticin receptor 2)
C: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
D: par-1b (homo sapiens) (aka microtubule affinity regulating kinase 2)
E: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have described a protein (Hep27)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
D: hel-s-27 (homo sapiens) (aka serpin family b member 1)
E: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hel-s-27 (homo sapiens) (aka serpin family b member 1)
E: es27 (homo sapiens) (aka ribosomal protein s27)
F: None of the above. | [A] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: es27 (homo sapiens) (aka ribosomal protein s27)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'This report describes the cloning and the characterization of the cDNA coding for the Hep27 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: es27 (homo sapiens) (aka ribosomal protein s27)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
F: None of the above. | [D] |
<Instruct>: Given the context 'The translation of the Hep27 cDNA predicts an amino acid sequence that can be aligned with those of the known short-chain alcohol dehydrogenase enzymes (SCAD) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
B: hel-s-27 (homo sapiens) (aka serpin family b member 1)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
F: None of the above. | [D] |
<Instruct>: Given the context 'In agreement with its nuclear localization Hep27 has a region similar to the bipartite nuclear-targeting sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
B: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
C: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
F: None of the above. | [D] |
<Instruct>: Given the context 'The study of Hep27 mRNA expression and protein synthesis suggests the existence of a regulation at the post-transcriptional level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
C: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The possible nuclear role of the Hep27 protein is discussed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
B: es27 (homo sapiens) (aka ribosomal protein s27)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
E: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
F: None of the above. | [E] |
<Instruct>: Given the context 'Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p53 (homo sapiens) (aka tumor protein p53)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: p53cp (homo sapiens) (aka tumor protein p63)
E: tumor protein p73 (homo sapiens) (aka tumor protein p73)
F: None of the above. | [B] |
<Instruct>: Given the context 'Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p53]
<Options>: A: p53 (homo sapiens) (aka tumor protein p53)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: tp73 (homo sapiens) (aka tumor protein p73)
F: None of the above. | [A] |
<Instruct>: Given the context 'One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: e6bp (homo sapiens) (aka reticulocalbin 2)
B: ebbp (homo sapiens) (aka tripartite motif containing 16)
C: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
D: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
E: ubc6p (homo sapiens) (aka ubiquitin conjugating enzyme e2 j1)
F: None of the above. | [A] |
<Instruct>: Given the context 'The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: ebbp (homo sapiens) (aka tripartite motif containing 16)
B: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
C: e6bp (homo sapiens) (aka reticulocalbin 2)
D: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
E: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
F: None of the above. | [C] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp; erc-55]
<Options>: A: testis expressed 55 (homo sapiens) (aka testis expressed 55)
B: e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
C: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
D: e6bp (homo sapiens) (aka reticulocalbin 2)
E: cancer/testis antigen 55 (homo sapiens) (aka cancer/testis antigen 55)
F: ubc6p (homo sapiens) (aka ubiquitin conjugating enzyme e2 j1)
G: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
H: putative dna-dependent atpase rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
I: testis expressed 55 (xenopus tropicalis) (aka testis expressed 55)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp; erc-55]
<Options>: A: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
B: rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
C: ercc5 (homo sapiens) (aka ercc excision repair 5, endonuclease)
D: e5 (human papillomavirus 16) (aka transforming protein e5)
E: ct55 (homo sapiens) (aka cancer/testis antigen 55)
F: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
G: e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
H: testis expressed 55 (xenopus tropicalis) (aka testis expressed 55)
I: e6bp (homo sapiens) (aka reticulocalbin 2)
J: None of the above. | [I; I] |
<Instruct>: Given the context 'A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: pi3kgamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
B: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
C: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
D: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
E: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
F: None of the above. | [A] |
<Instruct>: Given the context 'The p110 gamma enzyme was activated in vitro by both the alpha and beta gamma subunits of heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) and did not interact with p85.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
B: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
C: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
D: pik3cg (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
E: p110gamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
F: None of the above. | [D] |
<Instruct>: Given the context 'The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
B: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
C: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
D: pi3kgamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
E: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
F: None of the above. | [D] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
B: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
C: znf40 (homo sapiens) (aka hivep zinc finger 1)
D: znf140l (homo sapiens) (aka zinc finger protein 302)
E: znf136 (homo sapiens) (aka zinc finger protein 136)
F: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
G: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
H: znf404 (homo sapiens) (aka zinc finger protein 404)
I: znf140 (homo sapiens) (aka zinc finger protein 140)
J: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
K: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
L: rnf133 (homo sapiens) (aka ring finger protein 133)
M: znf132 (homo sapiens) (aka zinc finger protein 132)
N: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
O: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
P: None of the above. | [F; I; E] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
B: rnf133 (homo sapiens) (aka ring finger protein 133)
C: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
D: znf133 (homo sapiens) (aka zinc finger protein 133)
E: znf132 (homo sapiens) (aka zinc finger protein 132)
F: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
G: znf40a (homo sapiens) (aka hivep zinc finger 1)
H: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
I: znf140l (homo sapiens) (aka zinc finger protein 302)
J: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
K: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
L: znf140 (homo sapiens) (aka zinc finger protein 140)
M: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
N: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
O: None of the above. | [D; L; J] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
B: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
C: znf136 (homo sapiens) (aka zinc finger protein 136)
D: znf404 (homo sapiens) (aka zinc finger protein 404)
E: zinc finger protein 132 (homo sapiens) (aka zinc finger protein 132)
F: znf140 (homo sapiens) (aka zinc finger protein 140)
G: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
H: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
I: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
J: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
K: znf140l (homo sapiens) (aka zinc finger protein 302)
L: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
M: rnf133 (homo sapiens) (aka ring finger protein 133)
N: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
O: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
P: None of the above. | [I; F; C] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140]
<Options>: A: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
B: znf140l (homo sapiens) (aka zinc finger protein 302)
C: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
D: znf40a (homo sapiens) (aka hivep zinc finger 1)
E: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
F: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
G: znf132 (homo sapiens) (aka zinc finger protein 132)
H: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
I: rnf140 (homo sapiens) (aka deltex e3 ubiquitin ligase 1)
J: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
K: None of the above. | [J; A] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf133; znf140]
<Options>: A: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
B: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
C: znf404 (homo sapiens) (aka zinc finger protein 404)
D: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
E: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
F: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
G: zinc finger protein 132 (homo sapiens) (aka zinc finger protein 132)
H: znf140l (homo sapiens) (aka zinc finger protein 302)
I: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
J: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
K: None of the above. | [A; B] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
B: zinc finger cchc domain-containing protein 10 (glycine max) (aka zinc finger cchc domain-containing protein 10)
C: kox10 (homo sapiens) (aka zinc finger protein 17)
D: zinc finger and scan domain containing 10 (homo sapiens) (aka zinc finger and scan domain containing 10)
E: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
F: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
G: kox (homo sapiens) (aka nadph oxidase 4)
H: zinc finger and btb domain containing 10 (homo sapiens) (aka zinc finger and btb domain containing 10)
I: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
J: znf136 (homo sapiens) (aka zinc finger protein 136)
K: znf10 (homo sapiens) (aka zinc finger protein 10)
L: kox9 (homo sapiens) (aka zinc finger protein 16)
M: kox8 (homo sapiens) (aka zinc finger protein 708)
N: None of the above. | [J; K; K] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
B: zinc finger and scan domain containing 10 (homo sapiens) (aka zinc finger and scan domain containing 10)
C: znf136 (homo sapiens) (aka zinc finger protein 136)
D: zinc finger protein 10 (homo sapiens) (aka zinc finger protein 10)
E: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
F: kox10 (homo sapiens) (aka zinc finger protein 17)
G: phz-10 (homo sapiens) (aka zinc finger protein 131)
H: kox3 (homo sapiens) (aka zinc finger protein 12)
I: zinc finger cchc domain-containing protein 10 (glycine max) (aka zinc finger cchc domain-containing protein 10)
J: kox7 (homo sapiens) (aka zinc finger protein 44)
K: kox6 (homo sapiens) (aka zinc finger protein 14)
L: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
M: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
N: None of the above. | [C; D; D] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [znf136; znf10; kox1]
<Options>: A: kox10 (homo sapiens) (aka zinc finger protein 17)
B: kox4 (homo sapiens) (aka zinc finger protein 7)
C: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
D: kox8 (homo sapiens) (aka zinc finger protein 708)
E: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
F: znf210 (homo sapiens) (aka zinc finger protein 205)
G: fam161 homolog famh-136 (caenorhabditis elegans) (aka fam161 homolog famh-136)
H: kox-1 (homo sapiens) (aka nadph oxidase 4)
I: zinc finger protein 10 (homo sapiens) (aka zinc finger protein 10)
J: zinc finger and btb domain containing 10 (homo sapiens) (aka zinc finger and btb domain containing 10)
K: cg13612 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
L: zinc finger protein 10-like (glycine max) (aka zinc finger protein 10-like)
M: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
N: None of the above. | [E; I; I] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
B: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
C: sodium channel epithelial 1 subunit alpha (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
D: scn5a (sus scrofa) (aka sodium voltage-gated channel alpha subunit 5)
E: scnn1 (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
F: sodium voltage-gated channel alpha subunit 5 (homo sapiens) (aka sodium voltage-gated channel alpha subunit 5)
G: scn1 (homo sapiens) (sodium voltage-gated channel alpha subunit 1 (homo sapiens)) (aka sodium voltage-gated channel alpha subunit 1)
H: None of the above. | [F; F] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
B: sodium channel epithelial 1 subunit alpha (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
C: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
D: scn1 (homo sapiens) (sodium voltage-gated channel alpha subunit 1 (homo sapiens)) (aka sodium voltage-gated channel alpha subunit 1)
E: scn5a (sus scrofa) (aka sodium voltage-gated channel alpha subunit 5)
F: scnn1 (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
G: None of the above. | [G; G] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: nav1.5 (homo sapiens) (aka sodium voltage-gated channel alpha subunit 5)
B: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
C: sodium voltage-gated channel alpha subunit 1 (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
D: scn6a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 7)
E: scnn1 (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
F: scn1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
G: sodium channel epithelial 1 subunit alpha (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
H: None of the above. | [A; A] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
B: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
C: small subunit processome component 20 homolog (glycine max) (aka small subunit processome component 20 homolog)
D: cbp80 (saccharomyces cerevisiae s288c) (aka sto1p)
E: cbp68 (homo sapiens) (aka annexin a6)
F: nuclear cap-binding protein cbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
G: cbp20 (xenopus tropicalis) (aka nuclear cap binding protein subunit 2)
H: 4f (drosophila melanogaster) (eip4f (drosophila melanogaster)) (aka eip4f)
I: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
J: cbp86 (homo sapiens) (aka calcium binding tyrosine phosphorylation regulated)
K: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
L: eif-4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
M: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
N: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
O: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e4 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e4)
P: None of the above. | [L; A; B] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
B: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
C: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
D: cbp86 (homo sapiens) (aka calcium binding tyrosine phosphorylation regulated)
E: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e4 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e4)
F: fact80 (homo sapiens) (aka structure specific recognition protein 1)
G: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
H: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
I: 4f (drosophila melanogaster) (ecdysone-induced gene 4f (drosophila melanogaster)) (aka ecdysone-induced gene 4f)
J: small subunit processome component 20 homolog (glycine max) (aka small subunit processome component 20 homolog)
K: cbp20 (xenopus tropicalis) (aka nuclear cap binding protein subunit 2)
L: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
M: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
N: cbp80 (drosophila melanogaster) (aka cap binding protein 80)
O: nuclear cap-binding protein cbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
P: None of the above. | [B; A; H] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
B: cbp68 (homo sapiens) (aka annexin a6)
C: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
D: atcbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
E: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
F: 4f (drosophila melanogaster) (ecdysone-induced gene 4f (drosophila melanogaster)) (aka ecdysone-induced gene 4f)
G: small subunit processome component 20 homolog (glycine max) (aka small subunit processome component 20 homolog)
H: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
I: eif4f (homo sapiens) (eukaryotic translation initiation factor 4e (homo sapiens)) (aka eukaryotic translation initiation factor 4e)
J: cbp80 (saccharomyces cerevisiae s288c) (aka sto1p)
K: cbp80 (mus musculus) (aka nuclear cap binding protein subunit 1)
L: eif4f (drosophila melanogaster) (eukaryotic translation initiation factor 4e1 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 4e1)
M: cbp20 (xenopus tropicalis) (aka nuclear cap binding protein subunit 2)
N: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
O: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
P: None of the above. | [I; O; A] |
<Instruct>: Given the context 'Antibodies against recombinant CBP20 prevent interaction of CBC with capped RNAs in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cbp20]
<Options>: A: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
B: cbp20 (xenopus tropicalis) (aka nuclear cap binding protein subunit 2)
C: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
D: cap-binding protein 20 (arabidopsis thaliana) (aka cap-binding protein 20)
E: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
F: None of the above. | [A] |
<Instruct>: Given the context 'Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e]
<Options>: A: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
B: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
D: carboxypeptidase o (homo sapiens) (aka carboxypeptidase o)
E: carboxypeptidase e (caenorhabditis elegans) (aka carboxypeptidase e)
F: None of the above. | [A] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (caenorhabditis elegans) (aka carboxypeptidase e)
B: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
E: cpetr (homo sapiens) (aka claudin 4)
F: peptidase e (homo sapiens) (aka peptidase e)
G: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
H: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
I: cpe (gallus gallus) (aka carboxypeptidase e)
J: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
K: None of the above. | [J; J] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (xenopus tropicalis) (aka carboxypeptidase e)
B: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
C: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
D: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
E: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
F: cpepe (drosophila melanogaster) (aka silver)
G: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
H: carboxypeptidase e (caenorhabditis elegans) (aka carboxypeptidase e)
I: cpe (gallus gallus) (aka carboxypeptidase e)
J: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
K: None of the above. | [E; E] |
<Instruct>: Given the context 'We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE activity in extracts of fat/fat pancreatic islets and pituitaries.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
B: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: cpe (gallus gallus) (aka carboxypeptidase e)
E: cpetr (homo sapiens) (aka claudin 4)
F: None of the above. | [F] |
<Instruct>: Given the context 'A single Ser202Pro mutation distinguishes the mutant Cpe allele, and abolishes enzymatic activity in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
B: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
C: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
D: cpe (gallus gallus) (aka carboxypeptidase e)
E: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
F: None of the above. | [F] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (mus musculus) (aka translin)
D: translin (drosophila melanogaster) (aka translin)
E: translin (glycine max) (aka translin)
F: None of the above. | [A] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (mus musculus) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (glycine max) (aka translin)
D: translin (drosophila melanogaster) (aka translin)
E: None of the above. | [E] |
<Instruct>: Given the context 'We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (glycine max) (aka translin)
C: translin (homo sapiens) (aka translin)
D: translin (danio rerio) (aka translin)
E: translin-like (xenopus tropicalis) (aka translin-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (glycine max) (aka translin)
C: translin (homo sapiens) (aka translin)
D: translin (mus musculus) (aka translin)
E: translin-like (bos taurus) (aka translin-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'In the native form, Translin polypeptides form a multimeric structure which is responsible for its DNA binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (glycine max) (aka translin)
D: translin (sus scrofa) (aka translin)
E: translin (drosophila melanogaster) (aka translin)
F: None of the above. | [A] |
<Instruct>: Given the context 'Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR gene rearrangement.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (danio rerio) (aka translin)
B: translin-like (bos taurus) (aka translin-like)
C: translin (mus musculus) (aka translin)
D: translin (homo sapiens) (aka translin)
E: translin (xenopus tropicalis) (aka translin)
F: None of the above. | [D] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: 50kda (mus musculus) (aka polymerase (dna directed), delta 2, regulatory subunit)
B: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
C: adhalin (homo sapiens) (aka sarcoglycan alpha)
D: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
E: sarcoglycan, beta (dystrophin-associated glycoprotein) (mus musculus) (aka sarcoglycan, beta (dystrophin-associated glycoprotein))
F: apln (homo sapiens) (aka apelin)
G: sarcoglycan, delta (dystrophin-associated glycoprotein) (mus musculus) (aka sarcoglycan, delta (dystrophin-associated glycoprotein))
H: 50dag (mus musculus) (aka sarcoglycan, alpha (dystrophin-associated glycoprotein))
I: adn (homo sapiens) (aka complement factor d)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
B: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
C: sarcoglycan, alpha (dystrophin-associated glycoprotein) (mus musculus) (aka sarcoglycan, alpha (dystrophin-associated glycoprotein))
D: 50kda (mus musculus) (aka polymerase (dna directed), delta 2, regulatory subunit)
E: apln (homo sapiens) (aka apelin)
F: adhalin (homo sapiens) (aka sarcoglycan alpha)
G: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
H: ankyrin repeat domain 50 (mus musculus) (aka ankyrin repeat domain 50)
I: dctn-50 (mus musculus) (aka dynactin 2)
J: None of the above. | [F; F] |
<Instruct>: Given the context 'Adhalin deficiency has been found in SCARMD patients from North Africa Europe, Brazil, Japan and North America (SLR & KPC, unpublished data).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
C: adn (homo sapiens) (aka complement factor d)
D: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
E: adhalin (homo sapiens) (aka sarcoglycan alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: adn (homo sapiens) (aka complement factor d)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: adhalin (homo sapiens) (aka sarcoglycan alpha)
E: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
F: None of the above. | [D] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: adn (homo sapiens) (aka complement factor d)
B: apln (homo sapiens) (aka apelin)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
E: None of the above. | [E] |
<Instruct>: Given the context 'Thus there are two kinds of myopathies with adhalin deficiency: one with a primary defect of adhalin (primary adhalinopathies), and one in which absence of adhalin is secondary to a separate gene defect on chromosome 13.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
B: arcadlin (homo sapiens) (aka protocadherin 8)
C: apln (homo sapiens) (aka apelin)
D: adhalin (homo sapiens) (aka sarcoglycan alpha)
E: adn (homo sapiens) (aka complement factor d)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have examined the importance of primary adhalinopathies among myopathies with adhalin deficiency, and describe several additional mutations (null and missense) in the adhalin gene in 10 new families from Europe and North Africa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [adhalin]
<Options>: A: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
B: dystonin (homo sapiens) (aka dystonin)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: apln (homo sapiens) (aka apelin)
E: adhalin (homo sapiens) (aka sarcoglycan alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo sapiens)) (aka c-x-c motif chemokine receptor 1)
D: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
E: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
F: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
G: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
H: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
I: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
J: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
K: None of the above. | [H; H] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
B: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
C: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: cc-ckr-5 (homo sapiens) (aka c-c motif chemokine receptor 5)
E: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
F: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
G: c-x-c motif chemokine receptor 1 (homo sapiens) (aka c-x-c motif chemokine receptor 1)
H: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
I: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
J: c-c motif chemokine receptor 1 (homo sapiens) (aka c-c motif chemokine receptor 1)
K: None of the above. | [J; J] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
B: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
C: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
D: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
E: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
F: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
G: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
H: None of the above. | [H; H] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
D: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
E: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
F: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
G: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
H: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
I: None of the above. | [I; I] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
B: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
C: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
F: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
G: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
H: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
I: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
J: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
K: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
L: mip3b (homo sapiens) (aka c-c motif chemokine ligand 19)
M: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
N: scya7 (homo sapiens) (aka c-c motif chemokine ligand 7)
O: None of the above. | [O; F; F] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
B: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
C: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
D: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
E: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
F: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
G: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
H: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
I: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
J: c-c motif chemokine ligand 2 (homo sapiens) (aka c-c motif chemokine ligand 2)
K: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
L: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
M: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
N: c-c motif chemokine 3 (sus scrofa) (aka c-c motif chemokine 3)
O: None of the above. | [O; B; B] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: c-c motif chemokine ligand 2 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
D: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
E: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
F: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
G: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
H: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
I: c-c motif chemokine ligand 3 (homo sapiens) (aka c-c motif chemokine ligand 3)
J: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
K: c-x-c motif chemokine ligand 3 (homo sapiens) (aka c-x-c motif chemokine ligand 3)
L: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
M: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
N: scya7 (homo sapiens) (aka c-c motif chemokine ligand 7)
O: None of the above. | [O; G; G] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
B: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: ifn-alphac (homo sapiens) (aka interferon alpha 10)
D: il1f8 (homo sapiens) (aka interleukin 36 beta)
E: c3xkine (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
F: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
G: il18 (homo sapiens) (aka interleukin 18)
H: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
I: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
J: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
K: None of the above. | [I; I] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: groa (homo sapiens) (aka c-x-c motif chemokine ligand 1)
B: il1f8 (homo sapiens) (aka interleukin 36 beta)
C: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
E: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
F: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
G: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
H: il18 (homo sapiens) (aka interleukin 18)
I: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
J: ifn-alphac (homo sapiens) (aka interferon alpha 10)
K: None of the above. | [F; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
C: p-cip1 (homo sapiens) (aka ras association domain family member 9)
D: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
E: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
F: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
G: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
H: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
I: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
J: None of the above. | [I; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
E: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
F: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
G: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
H: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
I: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
J: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
K: None of the above. | [A; J] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
C: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
E: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
F: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
G: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
H: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
I: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
J: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
K: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
L: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
M: p-cip1 (homo sapiens) (aka ras association domain family member 9)
N: kip1 (homo sapiens) (cyclin dependent kinase inhibitor 1b (homo sapiens)) (aka cyclin dependent kinase inhibitor 1b)
O: None of the above. | [F; L; N] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
E: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
F: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
G: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
H: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
I: p-cip1 (homo sapiens) (aka ras association domain family member 9)
J: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
K: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
L: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
M: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
N: None of the above. | [F; B; N] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
E: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
F: p-cip1 (homo sapiens) (aka ras association domain family member 9)
G: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
H: kip1 (homo sapiens) (cyclin dependent kinase inhibitor 1b (homo sapiens)) (aka cyclin dependent kinase inhibitor 1b)
I: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
J: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
K: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
L: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
M: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
N: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
O: None of the above. | [I; G; H] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
C: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
D: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
E: p-cip1 (homo sapiens) (aka ras association domain family member 9)
F: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
G: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
H: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
I: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
J: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
K: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
L: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
M: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
N: None of the above. | [D; K; H] |
<Instruct>: Given the context 'p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
D: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
E: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
E: ckip-1 (homo sapiens) (aka pleckstrin homology domain containing o1)
F: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
G: p-cip1 (homo sapiens) (aka ras association domain family member 9)
H: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
I: tumor protein p73 (homo sapiens) (aka tumor protein p73)
J: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
K: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
L: cip2a (homo sapiens) (aka cellular inhibitor of pp2a)
M: p53 (homo sapiens) (aka tumor protein p53)
N: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
O: None of the above. | [J; K; M] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
E: ckip-1 (homo sapiens) (aka pleckstrin homology domain containing o1)
F: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
G: tumor protein p73 (homo sapiens) (aka tumor protein p73)
H: cip2a (homo sapiens) (aka cellular inhibitor of pp2a)
I: p-cip1 (homo sapiens) (aka ras association domain family member 9)
J: ct53 (homo sapiens) (aka zinc finger protein 165)
K: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
L: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
M: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
N: None of the above. | [D; F; N] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
B: cyclin dependent kinase inhibitor 2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: tp53 (homo sapiens) (aka tumor protein p53)
D: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
E: ct53 (homo sapiens) (aka zinc finger protein 165)
F: cip3 (homo sapiens) (aka exosome component 8)
G: cdkn1c (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
H: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
I: tumor protein p73 (homo sapiens) (aka tumor protein p73)
J: ckip-1 (homo sapiens) (aka pleckstrin homology domain containing o1)
K: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
L: rad53 (homo sapiens) (aka checkpoint kinase 2)
M: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
N: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
O: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
P: None of the above. | [D; H; C] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
F: cip3 (homo sapiens) (aka exosome component 8)
G: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
H: p53 (homo sapiens) (aka tumor protein p53)
I: rad53 (homo sapiens) (aka checkpoint kinase 2)
J: cdkn1c (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
K: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
L: ckip-1 (homo sapiens) (aka pleckstrin homology domain containing o1)
M: p53cp (homo sapiens) (aka tumor protein p63)
N: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
O: None of the above. | [N; K; H] |
<Instruct>: Given the context 'Overexpression of p57KIP2 arrests cells in G1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
B: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
D: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
E: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
F: None of the above. | [A] |
<Instruct>: Given the context 'p57KIP2 proteins have a complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
E: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p27kip1]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
C: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
D: p27kip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
E: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
F: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
G: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
H: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
I: kip1 (homo sapiens) (cyclin dependent kinase inhibitor 1b (homo sapiens)) (aka cyclin dependent kinase inhibitor 1b)
J: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p27kip1]
<Options>: A: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
B: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
C: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
D: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
E: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
F: kip1 (homo sapiens) (cyclin dependent kinase inhibitor 1b (homo sapiens)) (aka cyclin dependent kinase inhibitor 1b)
G: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
H: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
I: p27kip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
J: None of the above. | [J; F] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p27kip1]
<Options>: A: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
C: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
D: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
E: p27kip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
F: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
G: p27k (homo sapiens) (aka proteasome 20s subunit alpha 6)
H: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
I: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
J: None of the above. | [I; C] |
<Instruct>: Given the context 'Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
E: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
F: None of the above. | [E] |
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