instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [slap; eck]
<Options>: A: sla- (sus scrofa) (aka mhc class i antigen 1)
B: slap-2 (homo sapiens) (aka src like adaptor 2)
C: eek (homo sapiens) (aka eph receptor a8)
D: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
E: eck (homo sapiens) (aka eph receptor a2)
F: eck (mus musculu... | [D; E] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [slap; eck]
<Options>: A: eck (homo sapiens) (aka eph receptor a2)
B: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
C: cek7 (homo sapiens) (aka eph receptor a5)
D: slan (homo sapiens) (aka secis binding protein 2 like)
E: slat (homo sapiens) (aka def6 gua... | [I; A] |
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [slap]
<Options>: A: sla- (sus scrofa) (aka mhc class i antigen 1)
B: slan (homo sapiens) (aka secis binding protein 2 like)
C: slap-2 (homo sapiens) (aka src like adaptor 2)
D: sla (sus scrofa) (src like adaptor (sus scrofa)) (aka src like adaptor)
E: sla1p (homo sapiens) (aka src like adaptor)
F: None of ... | [E] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and... | <Mentions>: [cb1; cb2]
<Options>: A: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: cb1 (mus musculus) (aka cannabinoid receptor 1)... | [B; F] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and... | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: cb1a (homo sapiens) (ak... | [E; H] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1a (homo sapiens) (aka cannabinoid receptor 1)
D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
E: cb1r (mus musculus) (ak... | [C; D] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [cb1; cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cb1a (homo sapiens) (aka cannabinoid receptor 1)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: cb2 (ho... | [B; E] |
<Instruct>: Given the context 'CB1 was mainly expressed in the central nervous system and, to a lower extent, in several peripheral tissues such as adrenal gland, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus and tonsils.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [cb1]
<Options>: A: cb1r (homo sapiens) (aka cannabinoid receptor 1)
B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1r (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | [A] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cb2; cb1]
<Options>: A: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cb2 (homo sapiens) (aka cannabinoid receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cb1a (mus musculus) (aka cannabi... | [C; G] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cb2; cb1]
<Options>: A: cb1a (mus musculus) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: gprchr2 (homo sapiens) (aka g ... | [H; B] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cb2; cb1]
<Options>: A: cb1a (homo sapiens) (aka cannabinoid receptor 1)
B: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
E: cb2 (homo sapiens) (... | [E; A] |
<Instruct>: Given the context 'Although CB2 mRNA was also detected in some other peripheral tissues, its level remained very low.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
E: neurope... | [A] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cb1 (mus musculus) (aka cannabinoid receptor 1)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cb1r (homo sapiens) (aka cannabinoid receptor 1)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E: corticotropin releasing hormone receptor 2 (homo sa... | [H; C] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: cb1a (homo sapiens) (aka cannabinoid receptor 1)
E: gab... | [B; D] |
<Instruct>: Given the context 'Among the main human blood cell subpopulations, the distribution pattern of the CB2 mRNA displayed important variations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [cb2]
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b r... | [A] |
<Instruct>: Given the context 'The rank order of CB2 mRNA levels in these cells was B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [cb2]
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid... | [D] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
D: gprc2b (homo sapiens) (aka... | [C] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric ... | [E] |
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid ... | <Mentions>: [cb2]
<Options>: A: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cannabinoid rec... | [E] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct bi... | <Mentions>: [cb1; cb2]
<Options>: A: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cb1a (mus musculus) (aka cannabinoid receptor 1)
D: cb2 (homo sapiens) (aka cannabinoid receptor 2)
E: neuropeptides b and w receptor 2 (homo sapiens) (aka neu... | [H; D] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct bi... | <Mentions>: [cb1; cb2]
<Options>: A: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb1a (homo sapiens) (aka cannabinoid receptor 1)
E: cb2 (homo sa... | [D; E] |
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: coagulation factor ii thrombin receptor like 2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
B: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like)
C: par2 (homo sapiens) (f2r like trypsin recep... | [C] |
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
B: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation factor ii thrombin receptor like 2)
C: par2 (homo sapiens) (f2r like trypsin receptor 1 (ho... | [C] |
<Instruct>: Given the context 'By fluorescence in situ hybridization, the human proteinase-activated receptor 2 gene was mapped to chromosomal region 5q13, where, previously, the related thrombin receptor gene has been located.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2rl2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
B: prokr2 (homo sapiens) (aka prokineticin receptor 2)
C: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
D: par-1b (homo sapiens) (aka microtubule affinity regulating k... | [E] |
<Instruct>: Given the context 'We have described a protein (Hep27)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
D: hel-s-27 (homo sapiens) (aka serpin family b member 1)
E: hh27 (homo sapiens) (aka nescient helix-loop-h... | [B] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hel-s-27 (homo sapiens) (aka serpin family b member 1)
E: es27 (homo sapiens) (aka ribosomal protei... | [A] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: es27 (homo sapiens) (aka ribosomal protein s27)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'This report describes the cloning and the characterization of the cDNA coding for the Hep27 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: es27 (homo sapiens) (aka ribosomal protein s27)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: gp27 (homo sapiens) (aka cd151 molecule (raph blood g... | [D] |
<Instruct>: Given the context 'The translation of the Hep27 cDNA predicts an amino acid sequence that can be aligned with those of the known short-chain alcohol dehydrogenase enzymes (SCAD) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [hep27]
<Options>: A: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
B: hel-s-27 (homo sapiens) (aka serpin family b member 1)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: gp27 (homo sapiens) (aka cd151 molecule (raph b... | [D] |
<Instruct>: Given the context 'In agreement with its nuclear localization Hep27 has a region similar to the bipartite nuclear-targeting sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
B: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
C: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: lc27 (homo sapiens) (aka lys... | [D] |
<Instruct>: Given the context 'The study of Hep27 mRNA expression and protein synthesis suggests the existence of a regulation at the post-transcriptional level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [hep27]
<Options>: A: hel-s-27 (homo sapiens) (aka serpin family b member 1)
B: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
C: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: hsf-27 (homo sapiens) (aka cdk5 regulator... | [C] |
<Instruct>: Given the context 'The possible nuclear role of the Hep27 protein is discussed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
B: es27 (homo sapiens) (aka ribosomal protein s27)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
E: hep27 (homo sapiens) (aka dehydrogenase/reducta... | [E] |
<Instruct>: Given the context 'Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p53 (homo sapiens) (aka tumor protein p53)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: p53cp (homo sapiens) (aka tumor protein p63)
E: tumor protein p73 (homo sapiens) (aka tumor protein p73)
F: None of the above. | [B] |
<Instruct>: Given the context 'Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [p53]
<Options>: A: p53 (homo sapiens) (aka tumor protein p53)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p53cp (homo sapiens) (aka tumor protein p63)
D: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
E: tp73 (homo sapiens) (aka tumor protei... | [A] |
<Instruct>: Given the context 'One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: e6bp (homo sapiens) (aka reticulocalbin 2)
B: ebbp (homo sapiens) (aka tripartite motif containing 16)
C: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
D: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
E: ubc6p (homo sapiens) (aka ubiquitin con... | [A] |
<Instruct>: Given the context 'The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: ebbp (homo sapiens) (aka tripartite motif containing 16)
B: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
C: e6bp (homo sapiens) (aka reticulocalbin 2)
D: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
E: e3bp (homo sapiens) (aka pyruvate dehydrogenase comp... | [C] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [e6bp; erc-55]
<Options>: A: testis expressed 55 (homo sapiens) (aka testis expressed 55)
B: e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
C: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
D: e6bp (homo sapiens) (aka reticulocalbin 2)
E: cancer/testis antigen 55 ... | [D; D] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [e6bp; erc-55]
<Options>: A: e6-ap (homo sapiens) (aka ubiquitin protein ligase e3a)
B: rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
C: ercc5 (homo sapiens) (aka ercc excision repair 5, endonuclease)
D: e5 (human papillomavirus 16) (aka transforming protein e5)
E: ct55 (h... | [I; I] |
<Instruct>: Given the context 'A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: pi3kgamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
B: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
C: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-ki... | [A] |
<Instruct>: Given the context 'The p110 gamma enzyme was activated in vitro by both the alpha and beta gamma subunits of heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) and did not interact with p85.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [p110 gamma]
<Options>: A: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
B: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
C: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma... | [D] |
<Instruct>: Given the context 'The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [p110 gamma]
<Options>: A: pi3k-c2-gamma (homo sapiens) (aka phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
B: pi3kgamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
C: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosph... | [D] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
B: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
C: znf40 (homo sapiens) (aka hivep zinc finger 1)
D: znf140l (homo sapiens) (aka zinc finger protein 302)
E: znf136 (homo sapiens) (aka... | [F; I; E] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
B: rnf133 (homo sapiens) (aka ring finger protein 133)
C: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
D: znf133 (homo sapiens) (aka zinc finger protein 133)
E: ... | [D; L; J] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
B: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
C: znf136 (homo sapiens) (aka zinc finger protein 136)
D: znf404 (homo sapiens) (aka zinc finger protein 404)
E: zinc finger protei... | [I; F; C] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140]
<Options>: A: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
B: znf140l (homo sapiens) (aka zinc finger protein 302)
C: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
D: znf40a (homo sapiens) (aka hivep zinc finger 1)
E: zinc finger protein 136 (h... | [J; A] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140]
<Options>: A: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
B: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
C: znf404 (homo sapiens) (aka zinc finger protein 404)
D: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
E: bzip133 (glycine ... | [A; B] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
B: zinc finger cchc domain-containing protein 10 (glycine max) (aka zinc finger cchc domain-containing protein 10)
C: kox10 (homo sapiens) (aka zinc finger protein 17)
D: zinc finger and scan domain containing ... | [J; K; K] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
B: zinc finger and scan domain containing 10 (homo sapiens) (aka zinc finger and scan domain containing 10)
C: znf136 (homo sapiens) (aka zinc finger protein 136)
D: zinc finger protein... | [C; D; D] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: kox10 (homo sapiens) (aka zinc finger protein 17)
B: kox4 (homo sapiens) (aka zinc finger protein 7)
C: chromosome 8 c6orf136 homolog (xenopus tropicalis) (aka chromosome 8 c6orf136 homolog)
D: kox8 (homo sapiens) (aka zinc finger protein 708)
E: zinc finger protein 136 (... | [E; I; I] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
B: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
C: sodium channel epithelial 1 subunit alpha (homo sapiens) (aka sodium channel epit... | [F; F] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn5a (rattus norvegicus) (aka sodium voltage-gated channel alpha subunit 5)
B: sodium channel epithelial 1 subunit alpha (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
C: scn5a (mus musculus) (aka sodium channel, voltag... | [G; G] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: nav1.5 (homo sapiens) (aka sodium voltage-gated channel alpha subunit 5)
B: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
C: sodium voltage-gated channel alpha subunit 1 (homo sapiens) (aka sodium voltage-gated... | [A; A] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
B: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
C: small subunit processome component 20 homolog (glycine max) (aka small subunit processome component 20 homolog)
D: cbp80 (saccharomyces... | [L; A; B] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
B: eukaryotic translation initiation factor 4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
C: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation init... | [B; A; H] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
B: cbp68 (homo sapiens) (aka annexin a6)
C: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukaryotic translation initiation factor 4h)
D: atcbp80 (arabidopsis thaliana) (aka arm repeat sup... | [I; O; A] |
<Instruct>: Given the context 'Antibodies against recombinant CBP20 prevent interaction of CBC with capped RNAs in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cbp20]
<Options>: A: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
B: cbp20 (xenopus tropicalis) (aka nuclear cap binding protein subunit 2)
C: small subunit processome component 20 homolog (xenopus laevis) (aka small subunit processome component 20 homolog)
D: cap-binding protein 20 (ar... | [A] |
<Instruct>: Given the context 'Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [carboxypeptidase e]
<Options>: A: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
B: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
D: carboxypeptidase o (homo sapiens) (aka carboxypeptidase o)
E: carboxypeptidase e (caenorh... | [A] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (caenorhabditis elegans) (aka carboxypeptidase e)
B: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: carboxypeptidase e (oryctolagus cunicu... | [J; J] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (xenopus tropicalis) (aka carboxypeptidase e)
B: carboxypeptidase e (oryctolagus cuniculus) (cpe (oryctolagus cuniculus)) (aka carboxypeptidase e)
C: carboxypeptidase e (bos taurus) (aka carboxypeptidase e)
D: cpe1 (homo sapiens) (aka cytochrome p45... | [E; E] |
<Instruct>: Given the context 'We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE activity in extracts of fat/fat pancreatic islets and pituitaries.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [cpe]
<Options>: A: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
B: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: cpe (gallus gallus) (aka carboxypeptidase e)
E: c... | [F] |
<Instruct>: Given the context 'A single Ser202Pro mutation distinguishes the mutant Cpe allele, and abolishes enzymatic activity in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpeb (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 1)
B: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
C: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
D: cpe (gallus gallus) (aka carboxypeptidase e)
E: c... | [F] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (mus musculus) (aka translin)
D: translin (drosophila melanogaster) (aka translin)
E: translin (glycine max) (aka translin)
F: None of the above. | [A] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (mus musculus) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (glycine max) (aka translin)
D: translin (drosophila melanogaster) (aka translin)
E: None of the above. | [E] |
<Instruct>: Given the context 'We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (glycine max) (aka translin)
C: translin (homo sapiens) (aka translin)
D: translin (danio rerio) (aka translin)
E: translin-like (xenopus tropicalis) (aka translin-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (glycine max) (aka translin)
C: translin (homo sapiens) (aka translin)
D: translin (mus musculus) (aka translin)
E: translin-like (bos taurus) (aka translin-like)
F: None of the above. | [C] |
<Instruct>: Given the context 'In the native form, Translin polypeptides form a multimeric structure which is responsible for its DNA binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin (bos taurus) (aka translin)
C: translin (glycine max) (aka translin)
D: translin (sus scrofa) (aka translin)
E: translin (drosophila melanogaster) (aka translin)
F: None of the above. | [A] |
<Instruct>: Given the context 'Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR g... | <Mentions>: [translin]
<Options>: A: translin (danio rerio) (aka translin)
B: translin-like (bos taurus) (aka translin-like)
C: translin (mus musculus) (aka translin)
D: translin (homo sapiens) (aka translin)
E: translin (xenopus tropicalis) (aka translin)
F: None of the above. | [D] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: 50kda (mus musculus) (aka polymerase (dna directed), delta 2, regulatory subunit)
B: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
C: adhalin (homo sapiens) (aka sarcoglycan alpha)
D: anillin, actin binding protein ... | [C; C] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
B: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
C: sarcoglycan, alpha (dystrophin-associated glycoprotein) (mus musculus) (aka sarc... | [F; F] |
<Instruct>: Given the context 'Adhalin deficiency has been found in SCARMD patients from North Africa Europe, Brazil, Japan and North America (SLR & KPC, unpublished data).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
C: adn (homo sapiens) (aka complement factor d)
D: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
E: adhalin (homo sapiens) (aka sarcoglycan alpha)
F: N... | [E] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: adn (homo sapiens) (aka complement factor d)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: adhalin (homo sapiens) (aka sarcoglycan alpha)
E: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
F: None of the above. | [D] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [adhalin]
<Options>: A: adn (homo sapiens) (aka complement factor d)
B: apln (homo sapiens) (aka apelin)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
E: None of the above. | [E] |
<Instruct>: Given the context 'Thus there are two kinds of myopathies with adhalin deficiency: one with a primary defect of adhalin (primary adhalinopathies), and one in which absence of adhalin is secondary to a separate gene defect on chromosome 13.', select the correct biomedical concept for each mention using the p... | <Mentions>: [adhalin]
<Options>: A: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
B: arcadlin (homo sapiens) (aka protocadherin 8)
C: apln (homo sapiens) (aka apelin)
D: adhalin (homo sapiens) (aka sarcoglycan alpha)
E: adn (homo sapiens) (aka complement factor d)
F: None of the abo... | [D] |
<Instruct>: Given the context 'We have examined the importance of primary adhalinopathies among myopathies with adhalin deficiency, and describe several additional mutations (null and missense) in the adhalin gene in 10 new families from Europe and North Africa.', select the correct biomedical concept for each mention ... | <Mentions>: [adhalin]
<Options>: A: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
B: dystonin (homo sapiens) (aka dystonin)
C: anln (homo sapiens) (aka anillin, actin binding protein)
D: apln (homo sapiens) (aka apelin)
E: adhalin (homo sapiens) (aka sarcoglycan alpha)
F: None of the above. | [E] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: c-x3-c motif chemokine receptor 1 (homo sapiens) (aka c-x3-c motif chemokine receptor 1)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: ckr-1 (homo sapiens) (c-x-c motif chemokine receptor 1 (homo ... | [H; H] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
B: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
C: c-c motif chemokine receptor 6 (homo sapiens) (aka c-c motif chemokine receptor 6)
D: cc-ckr-5 (homo sapiens)... | [J; J] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', se... | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
B: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
C: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
D: mip-1d... | [H; H] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', se... | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
D: mip1a (homo sapiens) (aka c-c motif c... | [I; I] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
B: ccl25 (homo sapiens) (aka c-c motif chemokine ligand 25)
C: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
D: ifn-beta (homo sapiens) (aka interferon beta 1)
E: c-x-c motif chem... | [O; F; F] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
B: rantes (homo sapiens) (aka c-c motif chemokine ligand 5)
C: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
D: c-x3-c motif chemokine liga... | [O; B; B] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: c-c motif chemokine ligand 2 (homo sapiens) (aka c-c motif chemokine ligand 2)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
D: mip1ap (homo sapiens) (aka c-c ... | [O; G; G] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
B: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
C: ifn-alphac (homo sapiens) (aka interferon alpha 10)
D: il1f8 (homo sapiens) (aka interleukin 36 beta)
E: c3xkine (homo sapiens) (aka c-x... | [I; I] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: groa (homo sapiens) (aka c-x-c motif chemokine ligand 1)
B: il1f8 (homo sapiens) (aka interleukin 36 beta)
C: c-c motif chemokine ligand 8 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
E: fgf-8 (homo sap... | [F; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
C: p-cip1 (homo sapiens) (aka ras association domain family member 9)
D: p21cip1 (xen... | [I; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (ak... | [A; J] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
C: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family mem... | [F; L; N] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: p2... | [F; B; N] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo... | [I; G; H] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
C: cyclin-dependent kinase inhibitor 1b (p27, kip1) (xenopus tropicalis) (aka cyclin-dependent kinase... | [D; K; H] |
<Instruct>: Given the context 'p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodul... | [B] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
E: ckip-1 (homo sapiens) (aka pleckstrin homology d... | [J; K; M] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
C: rad53 (homo sapiens) (aka checkpoint kinase 2)
D: cip1 (homo sapiens) (cyclin dependent kinase inhibitor... | [D; F; N] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
B: cyclin dependent kinase inhibitor 2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: tp53 (homo sapiens) (aka tumor protein p53)
D: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)... | [D; H; C] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka in... | [N; K; H] |
<Instruct>: Given the context 'Overexpression of p57KIP2 arrests cells in G1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
B: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
C: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/cal... | [A] |
<Instruct>: Given the context 'p57KIP2 proteins have a complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
C: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cycl... | [C] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
B: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
C: cyclin dependent kinase inhibitor 1a (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
D: p27kip1 (x... | [G; I] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
B: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
C: cdkn2c (homo sapiens) (aka cyclin ... | [J; F] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: p21cip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
B: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
C: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
D: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
E: p27k... | [I; C] |
<Instruct>: Given the context 'Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [p57kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinas... | [E] |
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