instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Comparison of hKv beta 1.3 with the previously cloned hKv beta 3 and rKv beta 1 proteins indicates that the carboxyl-terminal 328 amino acids are identical, while unique variable length amino termini exist.', select the correct biomedical concept for each mention using the provided option... | <Mentions>: [hkv beta 1.3; hkv beta 3; rkv beta 1]
<Options>: A: kvbeta1.3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 1)
B: similar to rt1 class ii histocompatibility antigen, b-1 beta chain precursor (rt1.b-beta(1)) (rattus norvegicus) (aka similar to rt1 class ii hi... | [H; D; E] |
<Instruct>: Given the context 'Co-expression of hKv beta 1.3 in Xenopus oocytes with the delayed rectifier hKv1.5 indicated that hKv beta 1.3 has unique functional effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hkv beta 1.3; hkv1.5]
<Options>: A: kv-beta-3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 3)
B: potassium voltage-gated channel subfamily a member 5 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 5)
C: kvbeta1.3 (xenopus tropicalis) (aka p... | [D; B] |
<Instruct>: Given the context 'Co-expression of hKv beta 1.3 in Xenopus oocytes with the delayed rectifier hKv1.5 indicated that hKv beta 1.3 has unique functional effects.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [hkv beta 1.3; hkv1.5]
<Options>: A: k(v)1.5 (xenopus laevis) (potassium channel, voltage gated shaker related subfamily a, member 5 l homeolog (xenopus laevis)) (aka potassium channel, voltage gated shaker related subfamily a, member 5 l homeolog)
B: potassium channel, subfamily v, member 1 (mus musculus) ... | [H; E] |
<Instruct>: Given the context 'Most notably, hKv beta 1.3 converted the Kv1.5 outwardly rectifying current voltage relationship to one showing strong inward rectification.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hkv beta 1.3; kv1.5]
<Options>: A: kvbeta1.3 (xenopus tropicalis) (aka potassium channel, voltage gated subfamily a regulatory beta subunit 1)
B: task5 (homo sapiens) (aka potassium two pore domain channel subfamily k member 15)
C: kv-beta-1 (homo sapiens) (aka potassium voltage-gated channel subfamily a r... | [C; H] |
<Instruct>: Given the context 'Most notably, hKv beta 1.3 converted the Kv1.5 outwardly rectifying current voltage relationship to one showing strong inward rectification.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hkv beta 1.3; kv1.5]
<Options>: A: task-5 (homo sapiens) (aka potassium two pore domain channel subfamily k member 15)
B: kv-beta-2 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 2)
C: potassium channel, subfamily k, member 5 (mus musculus) (aka potassium channel, s... | [D; I] |
<Instruct>: Given the context 'De novo mutation of the myelin P0 gene in Dejerine-Sottas disease (hereditary motor and sensory neuropathy type III).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myelin p0]
<Options>: A: ribosomal protein lateral stalk subunit p0 (rattus norvegicus) (aka ribosomal protein lateral stalk subunit p0)
B: p0 (homo sapiens) (myelin protein zero (homo sapiens)) (aka myelin protein zero)
C: myelin protein zero-like 1 (rattus norvegicus) (aka myelin protein zero-like 1)
D: ... | [B] |
<Instruct>: Given the context 'We have investigated the myelin P0 gene on chromosome 1 as a candidate gene in two sporadic cases with Dejerine-Sottas disease or hereditary motor and sensory neuropathy (HMSN) type III.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [myelin p0]
<Options>: A: myelin protein zero-like 1 (rattus norvegicus) (aka myelin protein zero-like 1)
B: p0 (mus musculus) (aka myelin protein zero)
C: p0 (drosophila melanogaster) (aka ribosomal protein lp0)
D: myelin protein zero (homo sapiens) (aka myelin protein zero)
E: ribosomal protein lateral st... | [D] |
<Instruct>: Given the context 'The results strongly suggest that a de novo dominant mutation of the P0 gene is responsible for at least some sporadic cases of Dejerine-Sottas disease.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [p0]
<Options>: A: p0 (mus musculus) (aka myelin protein zero)
B: p0 (homo sapiens) (myelin protein zero (homo sapiens)) (aka myelin protein zero)
C: ribosomal protein, large, p0 (xenopus tropicalis) (aka ribosomal protein, large, p0)
D: p0 (rattus norvegicus) (aka myelin protein zero)
E: prlp0 (xenopus lae... | [B] |
<Instruct>: Given the context 'Human serum biotinidase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [biotinidase]
<Options>: A: biotinidase (oryctolagus cuniculus) (aka biotinidase)
B: biotinidase (rattus norvegicus) (aka biotinidase)
C: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
D: biotinidase (mus musculus) (aka biotinidase)
E: biotinidase (homo sapiens) (aka biotinidase)
F: None of the a... | [E] |
<Instruct>: Given the context 'cDNA cloning, sequence, and characterization.
Biotinidase (EC 3.5.1.12) catalyzes the hydrolysis of biocytin, the product of biotin-dependent carboxylase degradation, to biotin and lysine.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (homo sapiens) (aka biotinidase)
B: biotinidase (oryctolagus cuniculus) (aka biotinidase)
C: biotinidase (rattus norvegicus) (aka biotinidase)
D: biotinase (bos taurus) (aka biotinidase)
E: biotinidase (gallus gallus) (aka biotinidase)
F: None of the above. | [A] |
<Instruct>: Given the context 'Biotinidase deficiency is an inherited metabolic disorder of biotin recycling that is characterized by neurological and cutaneous abnormalities, and can be successfully treated with biotin supplementation.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (sus scrofa) (aka biotinidase)
B: biotinidase (rattus norvegicus) (aka biotinidase)
C: biotinidase (gallus gallus) (aka biotinidase)
D: biotinidase (mus musculus) (aka biotinidase)
E: biotinidase (homo sapiens) (aka biotinidase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Sequences of tryptic peptides of the purified human serum enzyme were used to design oligonucleotide primers for polymerase chain reaction amplification from human hepatic total RNA to generate putative biotinidase cDNA fragments.', select the correct biomedical concept for each mention u... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (gallus gallus) (aka biotinidase)
B: biotinidase (xenopus tropicalis) (aka biotinidase)
C: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
D: biotinidase (sus scrofa) (aka biotinidase)
E: biotinidase (homo sapiens) (aka biotinidase)
F: None of the above. | [E] |
<Instruct>: Given the context 'Comparison of the open reading frame with the known biotinidase tryptic peptides and recognition of the expressed protein encoded by this cDNA by monoclonal antibodies prepared against purified biotinidase demonstrated the identity of this cDNA.', select the correct biomedical concept for... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (rattus norvegicus) (aka biotinidase)
B: biotinidase (bos taurus) (aka biotinidase)
C: biotinidase (homo sapiens) (aka biotinidase)
D: biotinidase (xenopus laevis) (aka biotinidase l homeolog)
E: biotinidase (mus musculus) (aka biotinidase)
F: None of the above. | [C] |
<Instruct>: Given the context 'Southern analyses suggested that biotinidase is a single copy gene and revealed that human cDNA probes hybridized to genomic DNA from mammals, but not from chicken or yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (sus scrofa) (aka biotinidase)
B: biotinidase (oryctolagus cuniculus) (aka biotinidase)
C: biotinidase (xenopus tropicalis) (aka biotinidase)
D: biotinidase (homo sapiens) (aka biotinidase)
E: biotinidase (mus musculus) (aka biotinidase)
F: None of the above. | [D] |
<Instruct>: Given the context 'Southern analyses suggested that biotinidase is a single copy gene and revealed that human cDNA probes hybridized to genomic DNA from mammals, but not from chicken or yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (xenopus tropicalis) (aka biotinidase)
B: biotinidase (mus musculus) (aka biotinidase)
C: biotinidase (sus scrofa) (aka biotinidase)
D: biotinidase (oryctolagus cuniculus) (aka biotinidase)
E: None of the above. | [E] |
<Instruct>: Given the context 'Northern analysis indicated the presence of biotinidase mRNA in human heart, brain, placenta, liver, lung, skeletal muscle, kidney, and pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [biotinidase]
<Options>: A: biotinidase (gallus gallus) (aka biotinidase)
B: biotinidase (rattus norvegicus) (aka biotinidase)
C: biotinidase (oryctolagus cuniculus) (aka biotinidase)
D: biotinidase (homo sapiens) (aka biotinidase)
E: biotinidase (sus scrofa) (aka biotinidase)
F: None of the above. | [D] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
B: crk proto-oncogene, adaptor protein (homo sapiens) (aka crk proto-oncogene, adaptor protein)
C: grb2-b (xenopus tropicalis) (aka growth factor receptor bound protein 2)
D: crk (drosophila melanogas... | [S; B; L; L] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c1qg (homo sapiens) (aka complement c1q c chain)
B: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein)
C: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
D: crkii (xenopus laevis) (v-crk avian sarcoma virus ct10 oncogene... | [F; L; E; E] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: crk (drosophila melanogaster) (crk oncogene (drosophila melanogaster)) (aka crk oncogene)
B: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
C: grb2 related adaptor protein 2 (homo sapiens) (aka grb2 related adaptor protein 2)
D: arabidopsis ash2 relativ... | [B; K; I; I] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: crk proto-oncogene, adaptor protein (homo sapiens) (aka crk proto-oncogene, adaptor protein)
B: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
C: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein)
D: v-crk avian sarcoma... | [F; A; E; E] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
B: ashr1 (arabidopsis thaliana) (aka set domain group 37)
C: v-crk avian sarcoma virus ct10 oncogene homolog (mus musculus) (aka v-crk avian sarcoma virus... | [L; G; G] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: grb2l (homo sapiens) (aka grb2 related adaptor protein 2)
B: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco)
C: grb2 (bos taurus) (aka growth factor receptor bound protein 2)
D: v-crk avian sarcoma virus ct10 oncogene homolog (mus musculus) (aka v-crk avian sarco... | [N; M; M] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: ash (drosophila melanogaster) (aka absent, small, or homeotic discs 1)
B: crk7 (homo sapiens) (aka cyclin dependent kinase 12)
C: grb2-b (xenopus tropicalis) (aka growth factor receptor bound protein 2)
D: ash1 related protein 1 (arabidopsis thaliana) (aka set domain group 26)... | [L; M; M] |
<Instruct>: Given the context 'C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
CRK protein, together with GRB2/ASH and Nck proteins, belongs to the adaptor-type Src homology (SH)2-containing molecules, which transduce signals from tyr... | <Mentions>: [crk; grb2; ash]
<Options>: A: crk oncogene (drosophila melanogaster) (aka crk oncogene)
B: ash 1 (drosophila melanogaster) (aka absent, small, or homeotic discs 1)
C: ash1 (absent, small, or homeotic)-like s homeolog (xenopus laevis) (aka ash1 (absent, small, or homeotic)-like s homeolog)
D: crkii (xenopus... | [H; E; E] |
<Instruct>: Given the context 'Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk sh3-binding protein]
<Options>: A: crk like proto-oncogene, adaptor protein (homo sapiens) (aka crk like proto-oncogene, adaptor protein)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: crk (drosophil... | [J; J] |
<Instruct>: Given the context 'Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk sh3-binding protein]
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
B: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
C: ... | [F; F] |
<Instruct>: Given the context 'Here another guanine nucleotide-releasing protein (GNRP), C3G, has been identified as a CRK SH3-binding protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk sh3-binding protein]
<Options>: A: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
B: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
C: v-crk avian sarcoma virus ct10 oncogene homolog-like (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 onco... | [J; J] |
<Instruct>: Given the context 'The nucleotide sequence of a 4.1-kb C3G cDNA contains a 3.2-kb open reading frame encoding a 121-kDa protein, and antibodies against C3G have been shown to detect a protein of 130-140 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [c3g]
<Options>: A: c1qg (homo sapiens) (aka complement c1q c chain)
B: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
C: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
D: c3g (drosophila melanoga... | [B] |
<Instruct>: Given the context 'The carboxyl terminus of C3G has a peptide sequence homologous to GNRPs for Ras, and the expression of this carboxyl terminus region suppresses the loss of CDC25 function in the yeast Saccharomyces cerevisiae.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [c3g; cdc25]
<Options>: A: cdc25b (homo sapiens) (aka cell division cycle 25b)
B: cdc25 (xenopus laevis) (cell division cycle 25c s homeolog (xenopus laevis)) (aka cell division cycle 25c s homeolog)
C: c1qg (homo sapiens) (aka complement c1q c chain)
D: c3g (mus musculus) (aka rap guanine nucleotide exchan... | [J; G] |
<Instruct>: Given the context 'The carboxyl terminus of C3G has a peptide sequence homologous to GNRPs for Ras, and the expression of this carboxyl terminus region suppresses the loss of CDC25 function in the yeast Saccharomyces cerevisiae.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [c3g; cdc25]
<Options>: A: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
B: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
C: cdc25d (xenopus laevis) (provisional ortholog of cell division cycle 25c s homeolog (xenopus laevis)) (aka provisional ortholog of cell ... | [A; D] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c1qg (homo sapiens) (aka complement c1q c chain)
B: grb2l (homo sapiens) (aka grb2 related adaptor protein 2)
C: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
D: crkii (xenopus l... | [S; F; L; L] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
B: c1qg (homo sapiens) (aka complement c1q c chain)
C: grb2 associated binding protein 2 (homo sapiens) (aka grb2 associated binding protein 2)
D: v-crk avian sarcoma virus ct10 oncogene homolog (mus muscul... | [A; P; L; L] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: grb2 associated binding protein 2 (homo sapiens) (aka grb2 associated binding protein 2)
B: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
C: grb2l (homo sapiens) (aka grb2 related adaptor protein... | [F; N; H; H] |
<Instruct>: Given the context 'The C3G protein expressed in Escherichia coli binds to CRK and GRB2/ASH proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk; grb2; ash]
<Options>: A: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein)
B: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco)
C: v-crk avian sarcoma virus ct10 oncogene homolog (mus musculus) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
D: crk7 ... | [I; J; L; L] |
<Instruct>: Given the context 'Mutational analysis of C3G assigns the SH3 binding region to a 50-amino acid region containing a proline-rich sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [c3g]
<Options>: A: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
B: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
C: complement c8 gamma chain (homo sapiens) (aka complement c8 gamma chain)
D: c3b (homo sapiens) (aka complement c3)
E: c3g (rattus norvegicus) (a... | [A] |
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk]
<Options>: A: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
B: c3g (rattus norvegicus) (aka rap guanine nucleotide exchange factor 1)
C: crk proto-oncogene, adaptor protein (homo sapiens) (aka crk proto-oncogene, adaptor protein)
D: crk7 (homo sapiens) (aka cyclin depend... | [J; C] |
<Instruct>: Given the context 'The mRNAs of both the C3G and CRK proteins are expressed ubiquitously in human adult and fetal tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c3g; crk]
<Options>: A: c1qg (homo sapiens) (aka complement c1q c chain)
B: crk (homo sapiens) (aka crk proto-oncogene, adaptor protein)
C: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
D: crk (gallus gallus) (aka crk proto-oncogene, adaptor protein)
E: v-crk avian sarcoma virus ct10 on... | [C; B] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: gro... | [O; G; C; C] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: arabidopsis ash2 relative (arabidopsis thaliana) (aka trauco)
B: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
C: crk (gallus gallus) (aka crk proto-oncogene, adaptor protein)
D: grb2 ... | [Q; O; S; S] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: c3g (drosophila melanogaster) (crossover suppressor on 3 of gowen (drosophila melanogaster)) (aka crossover suppressor on 3 of gowen)
B: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
C: grb2 related adaptor protein (homo sapiens) (aka grb2 related adap... | [L; B; I; I] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: c3g (homo sapiens) (aka rap guanine nucleotide exchange factor 1)
B: grb2 related adaptor protein (homo sapiens) (aka grb2 related adaptor protein)
C: crk (gallus gallus) (aka crk proto-oncogene, adaptor protein)
D: arabidopsis ash2 relative (arabidopsis thaliana) (aka tr... | [H; A; M; M] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [crk; c3g; grb2; ash]
<Options>: A: v-crk avian sarcoma virus ct10 oncogene homolog (xenopus tropicalis) (aka v-crk avian sarcoma virus ct10 oncogene homolog)
B: gab2 (homo sapiens) (aka grb2 associated binding protein 2)
C: grb2-b (xenopus tropicalis) (aka growth factor receptor bound protein 2)
D: grb2l (... | [R; N; I; I] |
<Instruct>: Given the context 'The results of these studies suggest that the complex of CRK and C3G, or GRB2/ASH and C3G, may transduce the signals from tyrosine kinases to Ras in a number of different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [c3g]
<Options>: A: c3g (mus musculus) (aka rap guanine nucleotide exchange factor (gef) 1)
B: c3g (drosophila melanogaster) (c3g guanyl-nucleotide exchange factor (drosophila melanogaster)) (aka c3g guanyl-nucleotide exchange factor)
C: c1qg (homo sapiens) (aka complement c1q c chain)
D: c3g (homo sapiens)... | [D] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cyclin-dependent kinase 4 homolog (caenorhabditis elegans) (aka cyclin-dependent kinase 4 homolog)
B: cdc20 (homo sapiens) (aka cell division cycle 20)
C: p55cdc (homo sapiens) (aka cell division cycle 20)
D: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase... | [C; N; K] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
B: dna replication licensing factor mcm-4 (caenorhabditis elegans) (aka dna replication licensing factor mcm-4)
C: scf ubiquitin ligase complex subunit cdc4 (saccharomyces cerevisiae s288c) (aka scf ubiq... | [O; F; C] |
<Instruct>: Given the context 'A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.
', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cdc20a (homo sapiens) (aka cell division cycle 20)
B: cdc4 (candida albicans sc5314) (aka scf ubiquitin ligase complex subunit)
C: cdc24 (saccharomyces cerevisiae s288c) (aka rho family guanine nucleotide exchange factor cdc24)
D: cyclin-dependent kinase 4 homolog (caenor... | [F; N; J] |
<Instruct>: Given the context 'A novel protein, p55CDC, has been identified in cycling mammalian cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
B: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
D: p55cdc (homo sapiens) (aka cell division cycle 20)
E:... | [D] |
<Instruct>: Given the context 'The p55CDC protein appears to be essential for cell division, since transfection of antisense p55CDC cDNA into CHO cells resulted in isolation of only those cells which exhibited a compensatory increase in p55CDC transcripts in the sense orientation.', select the correct biomedical concep... | <Mentions>: [p55cdc]
<Options>: A: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
B: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
C: p55cdc (homo sapiens) (aka cell division cycle 20)
D: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
E: protein phosphatase 2a regulatory s... | [C] |
<Instruct>: Given the context 'Immunoprecipitation of p55CDC yielded protein complexes with kinase activity which fluctuated during the cell cycle.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20)
B: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
C: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosphatase 2a regulatory subunit cdc55)
D: p5cd (homo sapiens) (aka aldehyde... | [A] |
<Instruct>: Given the context 'Since p55CDC does not have the conserved protein kinase domains, this activity must be due to one or more of the associated proteins in the immune complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [p55cdc]
<Options>: A: p55cdc (mus musculus) (aka cell division cycle 20)
B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
C: p55cdc (homo sapiens) (aka cell division cycle 20)
D: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
E: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1... | [C] |
<Instruct>: Given the context 'The highest levels of protein kinase activity were seen with alpha-casein and myelin basic protein as substrates and demonstrated a pattern of activity distinct from that described for the known cyclin-dependent cell division kinases.', select the correct biomedical concept for each menti... | <Mentions>: [myelin basic protein]
<Options>: A: myelin associated oligodendrocyte basic protein (homo sapiens) (aka myelin associated oligodendrocyte basic protein)
B: myelin basic protein (homo sapiens) (aka myelin basic protein)
C: myelin basic protein (rattus norvegicus) (aka myelin basic protein)
D: myelin basic p... | [B] |
<Instruct>: Given the context 'The p55CDC protein was also phosphorylated in dividing cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: p55cdc (homo sapiens) (aka cell division cycle 20)
B: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
D: p55cdc (mus musculus) (aka cell division cycle 20)
E: cell division cycle 25c (homo sapiens) (aka cell divi... | [A] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cdc20[fizzy] (drosophila melanogaster) (aka fizzy)
B: p34cdc2 (homo sapiens) (aka cyclin dependent kinase 1)
C: mcm dna helicase complex subunit mcm4 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm4)
D: p55cdc (mus musculus) (aka cell division c... | [J; K; N] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
B: p55cdc (mus musculus) (aka cell division cycle 20)
C: cdc20b (homo sapiens) (aka cell division cycle 20b)
D: cdc24 (saccharomyces cerevisiae s288c) (aka rho family guanine nucleotide exchange factor c... | [H; F; M] |
<Instruct>: Given the context 'The amino acid sequence of p55CDC contains seven repeats homologous to the beta subunit of G proteins, and the highest degree of homology in these repeats was found with the Saccharomyces cerevisiae Cdc20 and Cdc4 proteins, which have been proposed to be involved in the formation of a fun... | <Mentions>: [p55cdc; cdc20; cdc4]
<Options>: A: cdc24 (saccharomyces cerevisiae s288c) (aka rho family guanine nucleotide exchange factor cdc24)
B: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
C: protein phosphatase 2a regulatory subunit cdc55 (saccharomyces cerevisiae s288c) (aka protein phosph... | [M; L; K] |
<Instruct>: Given the context 'The G beta repeat has been postulated to mediate protein-protein interactions and, in p55CDC, may modulate its association with a unique cell cycle protein kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, ... | <Mentions>: [p55cdc]
<Options>: A: p55cdc (mus musculus) (aka cell division cycle 20)
B: p5cdh (homo sapiens) (aka aldehyde dehydrogenase 4 family member a1)
C: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
D: p55cdc (homo sapiens) (aka cell division cycle 20)
E: cell division cycle 25c (homo sapiens) (aka c... | [D] |
<Instruct>: Given the context 'These findings suggest that p55CDC is a component of the mammalian cell cycle mechanism.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p55cdc]
<Options>: A: cell division cycle 25c (homo sapiens) (aka cell division cycle 25c)
B: p55cdc (homo sapiens) (aka cell division cycle 20)
C: p5c (homo sapiens) (aka pyrroline-5-carboxylate reductase 1)
D: p55cdc (xenopus tropicalis) (aka cell division cycle 20)
E: p5cdh (homo sapiens) (aka aldehyde ... | [B] |
<Instruct>: Given the context 'In the present study, serum from a patient with Sjögren's syndrome was used to identify a novel autoantigen which was designated Ge-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [ge-1]
<Options>: A: ge-1 (drosophila melanogaster) (aka ge-1)
B: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
C: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog)
D: esg (xenopus tropicalis) (transducin like enhanc... | [E] |
<Instruct>: Given the context 'In the present study, serum from a patient with Sjögren's syndrome was used to identify a novel autoantigen which was designated Ge-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [ge-1]
<Options>: A: ge-1 (drosophila melanogaster) (aka ge-1)
B: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog)
C: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
D: esg (xenopus tropicalis) (transducin like enhanc... | [E] |
<Instruct>: Given the context 'Using the patient's serum, a 4.8-kb cDNA encoding Ge-1 was identified.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ge-1]
<Options>: A: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
B: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1)
C: ge-1 (homo sapiens) (aka enhancer of mrna decapping 4)
D: ge-1 (xenopus tropicalis) (aka enhancer of mrna decapping 4)
E: ge-1 (xenopus laevis) (... | [C] |
<Instruct>: Given the context 'Fusion proteins containing different portions of Ge-1 were used to identify a 58 amino acid immunoreactive region within the protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [ge-1]
<Options>: A: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1)
B: ge-1 (drosophila melanogaster) (aka ge-1)
C: ge-1 (xenopus laevis) (enhancer of mrna decapping 4 l homeolog (xenopus laevis)) (aka enhancer of mrna decapping 4 l homeolog)
D: ge-1 (xenopus laevis) (enhancer of m... | [E] |
<Instruct>: Given the context 'The presence of the NLS motif within the immunoreactive region of Ge-1 and other nuclear autoantigens suggests that the NLS may be a target of human autoantibodies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [ge-1]
<Options>: A: gec1 (homo sapiens) (aka gaba type a receptor associated protein like 1)
B: esg (xenopus tropicalis) (transducin like enhancer of split 1 (xenopus tropicalis)) (aka transducin like enhancer of split 1)
C: ese-1 (homo sapiens) (aka e74 like ets transcription factor 3)
D: ge1 (homo sapien... | [D] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: aqp1 (homo sapiens) (aquaporin 1 (colton blood group) (homo sapiens)) (aka aquaporin 1 (colton blood group))
B: tmem128 (homo sapiens) (aka transmembrane protein 128)
C: aqpx1 (homo sapiens) (aka aquaporin 11)
D: aq... | [A; A; A; A] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: aqpx1 (homo sapiens) (aka aquaporin 11)
B: chip (arabidopsis thaliana) (aka carboxyl terminus of hsc70-interacting protein)
C: chip (drosophila melanogaster) (stip1 homology and u-box containing protein 1 (drosophil... | [J; J; J; J] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: small integral membrane protein 28 (homo sapiens) (aka small integral membrane protein 28)
B: katanin interacting protein (homo sapiens) (aka katanin interacting protein)
C: aqp0 (homo sapiens) (aka major intrinsic ... | [L; L; L; L] |
<Instruct>: Given the context 'Like aquaporin 1 (AQP1, also known as CHIP, channel-forming integral membrane protein of 28 kDa), the deduced polypeptide has six putative transmembrane domains but lacks cysteines at the known mercury-sensitive sites.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [aquaporin 1; aqp1; chip; channel-forming integral membrane protein of 28 kda]
<Options>: A: chip (homo sapiens) (aka stip1 homology and u-box containing protein 1)
B: aqp0 (homo sapiens) (aka major intrinsic protein of lens fiber)
C: aquaporin-1 (xenopus tropicalis) (aka aquaporin 1 (colton blood group))
D... | [D; D; D; D] |
<Instruct>: Given the context 'Its distinctive expression pattern implicates this fourth mammalian member of the aquaporin water channel family (designated gene symbol, AQP4) as the osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.', select the correct biomedical... | <Mentions>: [aqp4]
<Options>: A: provisional ortholog of aquaporin 4 (xenopus tropicalis) (aka provisional ortholog of aquaporin 4)
B: aqp4 (xenopus laevis) (aka aquaporin 4 l homeolog)
C: aqp4 (bos taurus) (aka aquaporin 4)
D: aqp4 (homo sapiens) (aka aquaporin 4)
E: aqp4 (mus musculus) (aka aquaporin 4)
F: None of th... | [D] |
<Instruct>: Given the context 'Its distinctive expression pattern implicates this fourth mammalian member of the aquaporin water channel family (designated gene symbol, AQP4) as the osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.', select the correct biomedical... | <Mentions>: [aqp4]
<Options>: A: provisional ortholog of aquaporin 4 (xenopus tropicalis) (aka provisional ortholog of aquaporin 4)
B: aqp4 (xenopus laevis) (aka aquaporin 4 l homeolog)
C: aqp4 (mus musculus) (aka aquaporin 4)
D: aqp4 (bos taurus) (aka aquaporin 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [vasopressin]
<Options>: A: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: avp (rattus norvegicus) (aka arginine vasopressin)
C: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l... | [D] |
<Instruct>: Given the context 'Water excretion by the kidney is regulated by the peptide hormone vasopressin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin]
<Options>: A: vasopressin (sus scrofa) (aka vasopressin)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: avp (rattus norvegicus) (aka arginine vasopressin)
D: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l ... | [E] |
<Instruct>: Given the context 'Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for e... | <Mentions>: [vasopressin]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: avp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
D: ... | [C] |
<Instruct>: Given the context 'Recently, a molecular water channel (AQP-CD) has been cloned whose expression appears to be limited to the collecting duct.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [aqp-cd]
<Options>: A: aqp-cd (homo sapiens) (aka aquaporin 2)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: aqp-cd (xenopus laevis) (aquaporin 2 s homeolog (xenopus laevis)) (aka aquaporin 2 s homeolog)
D: aqp-2 (oryctolagus cuniculus) (aka aquaporin 2)
E: aqp-cd (xenopus laevis) (aquaporin 2 l homeolog (x... | [A] |
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (homo sapiens) (aka aquaporin 2)
B: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
C: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
D: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
E: vasopressin... | [I; A] |
<Instruct>: Given the context 'Here, we test the hypothesis that vasopressin increases cellular water permeability by inducing exocytosis of AQP-CD-laden vesicles, transferring water channels from IVs to APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (mus musculus) (aka aquaporin 2)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: avp (rattus norvegicus) (aka arginine vasopressin)
D: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
E: vasopr... | [I; H] |
<Instruct>: Given the context 'Rat collecting ducts were perfused in vitro to determine water permeability and subcellular distribution of AQP-CD in the same tubules.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [aqp-cd]
<Options>: A: aqpcd (xenopus tropicalis) (aka aquaporin 2)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
D: aqp-cd (homo sapiens) (aka aquaporin 2)
E: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
F: No... | [D] |
<Instruct>: Given the context 'The collecting ducts were fixed for immunoelectron microscopy before, during, and after exposure to vasopressin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
C: vasopressin (sus scrofa) (aka vasopres... | [E] |
<Instruct>: Given the context 'The collecting ducts were fixed for immunoelectron microscopy before, during, and after exposure to vasopressin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin l homeolog (xenopus laevis)) (aka arginine vasopressin l homeolog)
B: vasopressin (sus scrofa) (aka vasopressin)
C: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
D: vasopressin (xenopus laevis) (arginine vas... | [E] |
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (sus scrofa) (aka vasopressin)
B: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
C: aqp-cd (xenopus tropicalis) (aka aquaporin 2)
D: arginine vasopressin (homo sapiens) (aka arginine vasopressin)
E: aqp-cd (orycto... | [D; I] |
<Instruct>: Given the context 'Vasopressin exposure induced increases in water permeability and the absolute labeling density of AQP-CD in the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: aqp-cd (mus musculus) (aka aquaporin 2)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
D: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus laevis)) (aka aquaporin 2 l homeolog)
E: vasopres... | [G; J] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (sus scrofa) (aka vasopressin)
B: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin)
C: vasotocin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
D: aqp-cd (xenopus tropi... | [B; I] |
<Instruct>: Given the context 'Furthermore, in response to vasopressin withdrawal, AQP-CD labeling density in the APM and the APM:IV labeling ratio decreased in parallel to a measured decrease in osmotic water permeability.', select the correct biomedical concept for each mention using the provided options. Answer by l... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
B: arginine vasopressin (xenopus tropicalis) (aka arginine vasopressin)
C: aqpcd (xenopus tropicalis) (aka aquaporin 2)
D: vp (homo sapiens) (arginine vasopressin (homo sapiens)) (aka arginine vasopressin... | [D; I] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: arginine vasopressin (rattus norvegicus) (aka arginine vasopressin)
B: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
C: aqp-cd (mus musculus) (aka aquaporin 2)
D: aqp-cd (homo sapiens) (aka aquaporin ... | [F; D] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: aqp-cd (mus musculus) (aka aquaporin 2)
C: vasopressin (sus scrofa) (aka vasopressin)
D: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
E: arginine v... | [I; J] |
<Instruct>: Given the context 'We conclude that vasopressin increases the water permeability of collecting duct cells by inducing a reversible translocation of AQP-CD water channels from IVs to the APM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [vasopressin; aqp-cd]
<Options>: A: vasopressin (xenopus laevis) (arginine vasopressin s homeolog (xenopus laevis)) (aka arginine vasopressin s homeolog)
B: aqp-cd (oryctolagus cuniculus) (aka aquaporin 2)
C: aqp-cd (mus musculus) (aka aquaporin 2)
D: aqpcd (xenopus laevis) (aquaporin 2 l homeolog (xenopus ... | [I; F] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [eaa4; glur6]
<Options>: A: ea8 (homo sapiens) (aka episodic ataxia, type 8)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2)
D: eaf4 (homo sapiens) (aka inhibitor of growth family member... | [B; B] |
<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [eaa4; glur6]
<Options>: A: eap4 (homo sapiens) (aka exosome component 6)
B: ea6 (homo sapiens) (aka solute carrier family 1 member 3)
C: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
D: eaa5 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 3)
E: mg... | [I; I] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [humeaa4; glur6]
<Options>: A: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
B: grg6 (homo sapiens) (aka tle family member 6, subcortical maternal complex member)
C: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
D: hypertension, essential, susceptibility to, 4 (homo sap... | [H; H] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [humeaa4; glur6]
<Options>: A: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
B: esa4 (homo sapiens) (aka esterase a4)
C: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
D: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8)
E: eca4 (ho... | [A; A] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [humeaa4; glur6]
<Options>: A: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8)
B: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2)
C: ela4 (homo sapiens) (aka chymotrypsin c)
D: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
E: eca4 (hom... | [I; I] |
<Instruct>: Given the context 'We have successfully established cell lines stably expressing humEAA4 in HEK-293 cells This is the first report of the establishment of stable cell lines expressing a glutamate receptor channel.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [humeaa4]
<Options>: A: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4)
B: esa4 (homo sapiens) (aka esterase a4)
C: hae4 (homo sapiens) (aka plasminogen)
D: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
E: saa4 (homo sapiens) (... | [D] |
<Instruct>: Given the context 'The relative potency of compounds for displacing [3H]-kainate binding to humEAA4 receptors expressed in COS or HEK-293 cells is domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.', select the correct b... | <Mentions>: [humeaa4]
<Options>: A: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
D: ela4 (homo sapiens) (aka chymotrypsin c)
E... | [B] |
<Instruct>: Given the context 'Applications of kainate, glutamate, and domoate but not AMPA evoked rapidly desensitizing currents in cells expressing homo-oligomeric humEAA4 in a concentration dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [humeaa4]
<Options>: A: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essential, susceptibility to, 4)
D: saa4 (homo sapiens)... | [B] |
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: saa4 (homo sapiens) (aka serum amyloid a4, constitutive)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: hae4 (homo sapiens) (aka plasminogen)
D: esa4 (homo sapiens) (aka esterase a4)
E: ele4 (homo sapiens) (aka regulatory region in intron 4 of pa... | [B] |
<Instruct>: Given the context 'To date this effect has not been demonstrated with rat GluR6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glur6]
<Options>: A: glutamate receptor 2.6 (glycine max) (aka glutamate receptor 2.6)
B: mglu6 (homo sapiens) (aka glutamate metabotropic receptor 6)
C: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8)
D: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
E: glr6 (h... | [E] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: cek7 (homo sapiens) (aka eph receptor a5)
B: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
C: src like adaptor (homo sapiens) (aka src like adaptor)
D: src like adaptor 2 (sus scrofa) (aka src like adaptor 2)
E: sla (sus scrofa) (src l... | [C; I] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: eck (homo sapiens) (aka eph receptor a2)
B: src like adaptor (sus scrofa) (aka src like adaptor)
C: ehk-2 (homo sapiens) (aka eph receptor a6)
D: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
E: src like adaptor (xenopus tropicalis) (aka src like adaptor... | [I; A] |
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select ... | <Mentions>: [eck]
<Options>: A: eck (homo sapiens) (aka eph receptor a2)
B: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk)
C: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
D: cek7 (homo sapiens) (aka eph receptor a5)
E: cek2 (homo sapiens) (aka fibro... | [A] |
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select ... | <Mentions>: [eck]
<Options>: A: cek7 (homo sapiens) (aka eph receptor a5)
B: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk)
C: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
D: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
E: None of t... | [E] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: src like adaptor 2 (homo sapiens) (aka src like adaptor 2)
B: src-like adaptor (mus musculus) (aka src-like adaptor)
C: src like adaptor 2 (sus scrofa) (aka src like adaptor 2)
D: slan (homo sapiens) (aka secis binding protein 2 like)
E: slap (homo sapiens) (sarcolemma... | [H; H] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
B: src like adaptor (xenopus tropicalis) (aka src like adaptor)
C: slan (homo sapiens) (aka secis binding protein 2 like)
D: slap (homo sapiens) (sarcolemma associated protein (ho... | [G; G] |
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