instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; non-a beta component of ad amyloid; nacp]
<Options>: A: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: amyloid beta precursor protein (homo sapiens) (aka amyloid beta precursor protein)
D: nac... | [G; G; G] |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; a beta]
<Options>: A: actr1b (homo sapiens) (aka actin related protein 1b)
B: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
C: actb (homo sapiens) (actin beta (homo sapiens)) (aka actin beta)
D: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
E:... | [H; K] |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nac; a beta]
<Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: actin beta (homo sapiens) (aka actin beta)
C: beta-naca (homo sapiens) (aka basic transcription factor 3)
D: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
E: nac1a (homo sapiens) (aka sodium voltage-gat... | [A; K] |
<Instruct>: Given the context 'Secondary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [nac]
<Options>: A: nac (drosophila melanogaster) (neuronally altered carbohydrate (drosophila melanogaster)) (aka neuronally altered carbohydrate)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
D: beta-nac... | [B] |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [nacp]
<Options>: A: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
B: nacb (homo sapiens) (aka basic transcription factor 3)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nac1a (homo sapiens) (aka sodium voltage-gated channel alph... | [C] |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept for each mention using the provided options. Answer by listing t... | <Mentions>: [nacp]
<Options>: A: nac (drosophila melanogaster) (nascent polypeptide associated complex protein alpha subunit (drosophila melanogaster)) (aka nascent polypeptide associated complex protein alpha subunit)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nac domain protein nac1 (glycine max) (aka nac domain... | [B] |
<Instruct>: Given the context 'The availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidosis in AD.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nacp]
<Options>: A: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
B: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nac1a (homo sapiens) (aka so... | [C] |
<Instruct>: Given the context 'Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
B: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
C: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
D: nuclear respiratory factor 1 (homo sapiens) (aka nuclear respir... | [B] |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept for each mention u... | <Mentions>: [nrf1; nf-e2-related factor 1]
<Options>: A: nrf1 (homo sapiens) (nfe2 like bzip transcription factor 1 (homo sapiens)) (aka nfe2 like bzip transcription factor 1)
B: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
C: nrff (escherichia coli str. k-12 substr. mg1655) (aka put... | [A; A] |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept for each mention u... | <Mentions>: [nrf1; nf-e2-related factor 1]
<Options>: A: nfe2 like bzip transcription factor 1 (xenopus tropicalis) (aka nfe2 like bzip transcription factor 1)
B: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
C: nfe2 like bzip transcription factor 1 (rattus norvegicus) (aka nfe2 like bzip transcription fa... | [I; I] |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept for each mention u... | <Mentions>: [nrf1; nf-e2-related factor 1]
<Options>: A: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
B: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
C: nuclear factor, erythroid derived 2,-like 1 (mus musculus) (aka nuclear factor, erythroid derived 2,-like 1)
D: nfe2l1_retired (... | [E; E] |
<Instruct>: Given the context 'Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [nrf1]
<Options>: A: nuclear respiratory factor 1 (homo sapiens) (aka nuclear respiratory factor 1)
B: nrf (homo sapiens) (aka nfkb repressing factor)
C: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
D: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
E: nrf-1 (homo sapiens... | [E] |
<Instruct>: Given the context 'Nrf1 activates transcription via NF-E2 binding sites in yeast cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nrf1]
<Options>: A: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
B: nrf (homo sapiens) (aka nfkb repressing factor)
C: nrbf1 (homo sapiens) (aka mitochondrial trans-2-enoyl-coa reductase)
D: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
E: nrf1 (rattus... | [A] |
<Instruct>: Given the context 'The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [nrf1]
<Options>: A: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
B: nrf (homo sapiens) (aka nfkb repressing factor)
C: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
D: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
E: nrbf1 (homo sapiens... | [C] |
<Instruct>: Given the context 'Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [beta-subunit of rod phosphodiesterase]
<Options>: A: phosphodiesterase 6b, cgmp-specific, rod, beta (danio rerio) (aka phosphodiesterase 6b, cgmp-specific, rod, beta)
B: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
C: pde1b (homo sapiens) (aka phosphodiesterase 1b)
D: rod cgmp-specific 3',5'-cycli... | [B] |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [beta-subunit of rod cgmp phosphodiesterase; pde beta]
<Options>: A: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
B: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
C: pde7b (homo sapiens) (aka phosphodiesterase 7b)
D: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
E: pde3b (homo s... | [D; D] |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [beta-subunit of rod cgmp phosphodiesterase; pde beta]
<Options>: A: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
B: pde1b (homo sapiens) (aka phosphodiesterase 1b)
C: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
D: pdeb (homo sapiens) (aka phosphodiesterase 6b)
E: pde3b (homo sapiens)... | [D; D] |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [beta-subunit of rod cgmp phosphodiesterase; pde beta]
<Options>: A: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
B: pde1b (homo sapiens) (aka phosphodiesterase 1b)
C: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
D: pde8b (homo sapiens) (aka phosphodiesterase 8b)
E: pde3b (homo sapiens... | [G; G] |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept for each me... | <Mentions>: [pde beta; rhodopsin]
<Options>: A: pde8b (homo sapiens) (aka phosphodiesterase 8b)
B: retinal pigment epithelium-derived rhodopsin homolog (bos taurus) (aka retinal pigment epithelium-derived rhodopsin homolog)
C: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
D: rhodopsin-1 (drosophila melanogaster) (ak... | [H; E] |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept for each me... | <Mentions>: [pde beta; rhodopsin]
<Options>: A: pde8b (homo sapiens) (aka phosphodiesterase 8b)
B: retinal pigment epithelium-derived rhodopsin homolog (gallus gallus) (aka retinal pigment epithelium-derived rhodopsin homolog)
C: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka retinal pig... | [J; D] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
C: nf-kb (hom... | [M; P; D; H] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
C: p65 (homo sapi... | [K; D; C; G] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: relb (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: nfkb-p105 (homo sapiens) (a... | [L; D; R; B] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nfkb-p105 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
C: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells... | [L; N; E; O] |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nfkb-p50 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subuni... | [K; A; B; P] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
C: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytop... | [L; J; P; H] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and ... | [J; G; H; F] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
B: nf-kb (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
D: v-rel avian reticuloendotheliosis v... | [C; L; P; J] |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept for each mention using the provided options. Answer by lis... | <Mentions>: [c-rel; nf-kappa bp50; nf-kappa bp65; lyt-10]
<Options>: A: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
B: rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
C: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopu... | [B; G; K; L] |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50]
<Options>: A: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit ... | [G; H] |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50]
<Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb sub... | [B; H] |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c-rel; nf-kappa bp50]
<Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela p... | [I; J] |
<Instruct>: Given the context 'The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [lyt-10]
<Options>: A: lyt10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: ip-10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
C: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
D: ilt10 (homo sapiens) (aka leukocyte immu... | [A] |
<Instruct>: Given the context 'NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [nf-kappa bp65]
<Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela pr... | [B] |
<Instruct>: Given the context 'Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [valyl-trna synthetase]
<Options>: A: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
B: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 1 (xenopus tropicalis) (... | [C] |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [valyl-trna synthetase; trsval]
<Options>: A: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
B: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
D: trsval (rattus norve... | [D; D] |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [valyl-trna synthetase; trsval]
<Options>: A: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
D: valyl trna synthetase (arabidops... | [C; C] |
<Instruct>: Given the context 'Three independent plaque clones containing the human TrsVal cDNA were then isolated from a lambda gt10 human erythroleukemia cDNA library using the rat cDNA fragment as the hybridization probe.', select the correct biomedical concept for each mention using the provided options. Answer by ... | <Mentions>: [trsval]
<Options>: A: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
B: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
E: valyl-tr... | [C] |
<Instruct>: Given the context 'The deduced 1051-amino-acid sequence shares 65% identity with yeast TrsVal, and contains a highly basic N-terminal region, a newly evolved protease-sensitive region in sequence close to the C terminus, and several sites for protein kinase C phosphorylation.', select the correct biomedical... | <Mentions>: [trsval]
<Options>: A: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase-like protein)
C: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
D: val... | [E] |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [trsval]
<Options>: A: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
B: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-t... | [C] |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [trsval]
<Options>: A: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
B: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synth... | [E] |
<Instruct>: Given the context 'These results confirm the cloning and sequencing of a human TrsVal-encoding cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trsval]
<Options>: A: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
C: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-t... | [D] |
<Instruct>: Given the context 'Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [calmodulin-like protein clp]
<Options>: A: caml (homo sapiens) (aka calcium modulating ligand)
B: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
C: calponin-like proteins (caenorhabditis elegans) (aka calponin-like proteins)
D: calmodulin-like protein (arabidopsis thaliana) (aka calmodulin-like p... | [B] |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [calmodulin-like protein; clp]
<Options>: A: calmodulin-like 3 (mus musculus) (aka calmodulin-like 3)
B: calmodulin-like (glycine max) (aka calmodulin-like)
C: clps (oryctolagus cuniculus) (aka colipase)
D: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
E: clpx (... | [I; I] |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [calmodulin-like protein; clp]
<Options>: A: clpa (homo sapiens) (aka t-box transcription factor 22)
B: clps (oryctolagus cuniculus) (aka colipase)
C: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
D: calmodulin like 6 (homo sapiens) (aka calmodulin like 6)
E: calmodulin-like (bos... | [I; I] |
<Instruct>: Given the context 'Chromosomal assignment was performed by Southern blot analysis of DNA from human-rodent somatic cell hybrids and amplification of a CLP gene-specific 1090-bp DNA fragment by the polymerase chain reaction (PCR) on DNA from human-hamster cell hybrids.', select the correct biomedical concept... | <Mentions>: [clp]
<Options>: A: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
B: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
C: clps (oryctolagus cuniculus) (aka colipase)
D: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase ... | [F] |
<Instruct>: Given the context 'The CLP gene is the first member of the human calmodulin/calmodulin-like gene family to be chromosomally sublocalized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [clp]
<Options>: A: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
B: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
C: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: clpx (homo sapiens) (ak... | [F] |
<Instruct>: Given the context 'The generation of a human CLP gene-specific sequence tag site specified by the two primers used for PCR should prove useful for future linkage studies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [clp]
<Options>: A: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
B: clps (oryctolagus cuniculus) (aka colipase)
C: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: clps (homo sapiens) (aka colipase)
E: clpp (homo sapiens) (aka casein... | [F] |
<Instruct>: Given the context 'A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cytochrome p-450 family 4]
<Options>: A: cytochrome p450 family 3 subfamily a member 4 (homo sapiens) (aka cytochrome p450 family 3 subfamily a member 4)
B: cytochrome p450 family 4 subfamily f member 2 (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 2)
C: cytochrome p450, family 4, subfami... | [D] |
<Instruct>: Given the context 'A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cytochrome p-450 family 4]
<Options>: A: cytochrome p450 family 4 subfamily f member 8 (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 8)
B: cytochrome p450 family 3 subfamily a member 4 (homo sapiens) (aka cytochrome p450 family 3 subfamily a member 4)
C: cytochrome p450, family 4, subfami... | [E] |
<Instruct>: Given the context 'cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [leukotriene b4 omega-hydroxylase]
<Options>: A: lta4h (homo sapiens) (aka leukotriene a4 hydrolase)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
D: cytochrome p450 2b4-like (xenopu... | [B] |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [leukotriene b4 (ltb4) omega-hydroxylase]
<Options>: A: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
B: lox4 (glycine max) (aka lipoxygenase)
C: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
D: leukotriene-b(4) omega-hydroxylase 2-like (bos taurus) (aka leukotriene-b(4) o... | [A] |
<Instruct>: Given the context 'The microsomes from yeast cells transfected with an expression vector pAAH5 carrying isolated cDNA catalyzed the omega-hydroxylation of LTB4 with a Km value of 0.71 microM, and its activity was significantly inhibited by carbon monoxide and by antisera against CYP4A4, consistent with the ... | <Mentions>: [ltb4 omega-hydroxylase]
<Options>: A: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
D: lta4h (homo sapiens) (aka leuko... | [B] |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [ltb4 omega-hydroxylase; p-450ltb omega]
<Options>: A: cytochrome p450 lm4 (oryctolagus cuniculus) (aka cytochrome p450 lm4)
B: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
C: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
D: cytochrome p450 2b4-... | [H; H] |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept for each mention using the provided o... | <Mentions>: [ltb4 omega-hydroxylase; p-450ltb omega]
<Options>: A: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: p-450ib (oryctolagus cuniculus) (aka cytochrome p450 family 2 subfamily j member 2)
D: cyp2b4 (oryctolagus cuniculus) (a... | [B; B] |
<Instruct>: Given the context 'According to the systematic classification of the P-450 superfamily, P-450LTB omega is classified into the CYP4 family but does not belong to any of the known CYP4 subfamilies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [p-450ltb omega]
<Options>: A: p450-lm2 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
B: cytochrome p450 2b4-like (xenopus tropicalis) (aka cytochrome p450 2b4-like)
C: cytochrome p450 lm4 (oryctolagus cuniculus) (aka cytochrome p450 lm4)
D: ltb4h (homo sapiens) (aka cy... | [D] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [catalytic subunit of human dna polymerase epsilon]
<Options>: A: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, catalytic subunit)
B: dna polymerase eta (homo sapiens) (aka dna polymerase eta)
C: dna polymerase epsilon 2, accessory subunit (homo sapiens) (aka dna poly... | [A] |
<Instruct>: Given the context 'The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [catalytic polypeptide of human dna polymerase epsilon]
<Options>: A: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
B: dna polymerase epsilon catalytic subunit (saccharomyces cerevisiae s288c) (aka dna polymerase epsilon catalytic subunit)
C: dna po... | [E] |
<Instruct>: Given the context 'The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [catalytic polypeptide of human dna polymerase epsilon]
<Options>: A: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
B: polymerase (dna directed), epsilon (mus musculus) (aka polymerase (dna directed), epsilon)
C: dna polymerase epsilon catalytic sub... | [E] |
<Instruct>: Given the context 'cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta-subunit of the human electron-transfer flavoprotein]
<Options>: A: electron transfer flavoprotein dehydrogenase (homo sapiens) (aka electron transfer flavoprotein dehydrogenase)
B: hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit beta (homo sapiens) (aka hydroxyacyl-coa dehydrog... | [D] |
<Instruct>: Given the context 'We have isolated a cDNA clone which encodes the entire beta-subunit of human electron-transferring flavoprotein (ETF) by screening an expression library from human liver using polyclonal antibodies against porcine ETF.', select the correct biomedical concept for each mention using the pro... | <Mentions>: [beta-subunit of human electron-transferring flavoprotein]
<Options>: A: electron transfer flavoprotein subunit beta (xenopus tropicalis) (aka electron transfer flavoprotein subunit beta)
B: electron transfer flavoprotein dehydrogenase (homo sapiens) (aka electron transfer flavoprotein dehydrogenase)
C: ele... | [E] |
<Instruct>: Given the context 'This cDNA encodes a protein of 255 amino-acid residues with a predicted molecular mass of 27,877 Da which shows a high degree of similarity with partial amino-acid sequences obtained from both rat liver and Paracoccus denitrificans beta-ETF.', select the correct biomedical concept for eac... | <Mentions>: [beta-etf]
<Options>: A: ebf (homo sapiens) (aka ebf transcription factor 1)
B: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
C: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
D: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
E: etf (h... | [B] |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [beta-etf]
<Options>: A: etfb (bos taurus) (aka electron transfer flavoprotein subunit beta)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
D: etf1 (homo sapiens) (aka eukaryotic translatio... | [C] |
<Instruct>: Given the context 'Incubation with intact mitochondria indicates that the cDNA-encoded beta-ETF polypeptide contains the information necessary to reach the mitochondrial matrix.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [beta-etf]
<Options>: A: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
B: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
C: etf (homo sapiens) (aka tea domain transcription factor 2)
D: ebf (homo sapiens) (aka ebf... | [A] |
<Instruct>: Given the context 'These data are in agreement with previous experiments suggesting that beta-ETF, unlike the majority of nuclear-encoded mitochondrial matrix proteins, does not have a cleavable leader peptide.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [beta-etf]
<Options>: A: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
B: etf (homo sapiens) (aka tea domain transcription factor 2)
C: ebf (homo sapiens) (aka ebf transcription factor 1)
D: etfb (homo sapiens) (aka electron transfer flavoprotein subunit beta)
E: etf1 (homo ... | [D] |
<Instruct>: Given the context 'Interestingly, the sequence analysis of beta-ETF protein identifies a 26.3% identity with the Fix A gene product of the nitrogen-fixing bacterium Azorhizobium caulinodans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [beta-etf]
<Options>: A: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
D: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subuni... | [D] |
<Instruct>: Given the context 'Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [glya]
<Options>: A: glyi (homo sapiens) (aka glyoxalase i)
B: gsa (glycine max) (aka glutamate 1-semialdehyde aminotransferase)
C: glya (escherichia coli str. k-12 substr. mg1655) (aka serine hydroxymethyltransferase)
D: glyoxalase i (glycine max) (aka lactoylglutathione lyase)
E: glycine receptor alpha 1 ... | [C] |
<Instruct>: Given the context 'Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
B: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
C: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
D: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inac... | [B] |
<Instruct>: Given the context 'CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [fkbp12]
<Options>: A: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
B: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
C: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
D: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
E: fkbp11 (hom... | [A] |
<Instruct>: Given the context 'CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively).', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [fkbp12]
<Options>: A: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
B: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
C: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
D: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
E: None of the above. | [E] |
<Instruct>: Given the context 'We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [fkbp12]
<Options>: A: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
B: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
C: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
D: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
E: fkbpl (homo sapien... | [C] |
<Instruct>: Given the context 'In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fkbp12]
<Options>: A: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
B: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))... | [B] |
<Instruct>: Given the context 'The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [fkbp12]
<Options>: A: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
B: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
C: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
D: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
E: fkbp13 (homo sapiens) (aka fk... | [B] |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccr1 (homo sapiens) (aka letm1 do... | [A] |
<Instruct>: Given the context 'A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
E: hcc3 (homo sapiens) (aka fun14 domain containing... | [B] |
<Instruct>: Given the context 'HCC-1 has a relative molecular mass of 8,673 and consists of 74 amino acids including four cysteines linked to disulfide bonds.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [hcc-1]
<Options>: A: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcc5 (homo sapiens) (aka minichromosome maintena... | [D] |
<Instruct>: Given the context 'HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by... | <Mentions>: [hcc-1]
<Options>: A: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
B: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: hccr1 (homo sapiens) (aka letm1 domain containing 1)
E: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity... | [B] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
B: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
C: hccr1 (homo sapiens) (aka letm1 domain containing 1)
D: mip3b (homo sapiens)... | [K; A; M] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: mip2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
B: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
C: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
D: mip3b (homo sapiens... | [N; F; J] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: hccr1 (homo sapiens) (aka letm1 domain containing 1)
B: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)... | [E; M; D] |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [hcc-1; macrophage inflammatory protein (mip)-1 alpha; mip-1 beta]
<Options>: A: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
B: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
C: hccr1 (homo sapiens) (aka letm1 domain containing 1)
D: mip-1-beta (homo sapiens... | [M; N; L] |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept for each mention... | <Mentions>: [mip-1 alpha; hcc-1]
<Options>: A: hcc3 (homo sapiens) (aka fun14 domain containing 2)
B: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
C: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
D: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hccs-1 (homo sapiens) (aka suppressor of... | [C; D] |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept for each mention... | <Mentions>: [mip-1 alpha; hcc-1]
<Options>: A: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
C: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
D: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
E: ... | [J; A] |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept for each mention... | <Mentions>: [mip-1 alpha; hcc-1]
<Options>: A: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
B: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
E: c-c motif chemokine ligand 1 (... | [H; J] |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; mip-1 alpha]
<Options>: A: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
B: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
E: hcc3 (homo sapiens) (aka fun14... | [F; A] |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1; mip-1 alpha]
<Options>: A: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hccr1 (homo sapiens) (aka letm1 domain containing 1)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
E: mip-4a (homo sapiens) (aka c-c motif ... | [A; D] |
<Instruct>: Given the context 'In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hcc-1]
<Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
E: hcc-1/hcc-3 (homo sapiens) (aka ... | [E] |
<Instruct>: Given the context 'It was as effective as MIP-1 alpha, but about 100-fold less potent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mip-1 alpha]
<Options>: A: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
D: mip1b (homo sapiens) (aka c-c motif chemoki... | [E] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [laf-4; af-4; mll]
<Options>: A: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
B: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
C: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage l... | [H; I; D] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [laf-4; af-4; mll]
<Options>: A: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
B: mllt7 (homo sapiens) (aka forkhead box o4)
C: af1 (homo sapiens) (aka ephrin a5)
D: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
E: aff4 (homo sapiens) (aka alf transcription elongati... | [K; O; J] |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [laf-4; af-4; mll]
<Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: af4 (mus musculus) (af4/fmr2 f... | [K; F; G] |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [laf-4; af-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1)... | [A; D] |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [laf-4; af-4]
<Options>: A: af4 (homo sapiens) (aka alf transcription elongation factor 1)
B: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
C: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
D: laf4 (homo sapiens) (aka alf transcription elongat... | [D; A] |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [af-4; mll]
<Options>: A: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
B: af1 (homo sapiens) (aka ephrin a5)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofacto... | [E; H] |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [af-4; mll]
<Options>: A: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
B: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
C: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
D: af4 (homo sapiens) (aka alf transcri... | [D; I] |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [af-4; laf-4]
<Options>: A: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
B: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: af6 (homo sapiens) (aka afadin, adherens junc... | [C; J] |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [af-4; laf-4]
<Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: af4 (homo sapiens) (aka alf transcription elongation factor 1)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
E: ... | [B; C] |
<Instruct>: Given the context 'Human LAF-4 readily hybridized with genes in mouse and chicken, thus showing that this gene family has been highly conserved during vertebrate evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [laf-4]
<Options>: A: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
B: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: laf4l (rattus norvegicus) (ak... | [D] |
<Instruct>: Given the context 'In mouse tissues, LAF-4 mRNA was found to be present at highest levels in lymphoid tissues, present at lower levels in brain and lung, and absent from other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [laf-4]
<Options>: A: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
B: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: laf4 (rattus nor... | [D] |
<Instruct>: Given the context 'In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development.', select the correct biomedical concept for each mention using t... | <Mentions>: [laf-4]
<Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
C: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: laf4l (mus musculus) (ak... | [D] |
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