instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development.', select the correct biomedical concept for each mention using t... | <Mentions>: [laf-4]
<Options>: A: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
D: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
E: None of the above. | [E] |
<Instruct>: Given the context 'Antibodies to LAF-4 showed it to be a nuclear protein that showed an uneven, granular immunofluorescence pattern.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
C: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
D: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
E: laf4 ... | [A] |
<Instruct>: Given the context 'In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [laf-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
E: l... | [A] |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [laf-4; af-4]
<Options>: A: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
D: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
E: af4 (homo s... | [F; E] |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by sem... | <Mentions>: [laf-4; af-4]
<Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1... | [A; D] |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [mll; af-4]
<Options>: A: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
B: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
C: af9 (homo sapiens) (aka mllt3 super elongation c... | [H; I] |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [mll; af-4]
<Options>: A: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: af1 (homo sapiens) (aka ephrin a5)
E: af4 (mus muscu... | [B; F] |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [mll; af-4]
<Options>: A: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
B: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: myeloid/lymphoid or mixed-lineage leukemia... | [I; G] |
<Instruct>: Given the context 'Therefore, the cloning of LAF-4 has defined a new family of potential regulatory proteins that may function in lymphoid development and oncogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [laf-4]
<Options>: A: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
B: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
E: aff4 (homo sapiens)... | [C] |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ubc-4; ubch5]
<Options>: A: ubcm4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
B: ubc4 (saccharomyces cerevisiae s288c) (aka e2 ubiquitin-conjugating protein ubc4)
C: ubch4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
D: ubc4 (glycine max) (aka ubiquitin carrier protein 4)
E: ubch6 (h... | [B; J] |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ubc-4; ubch5]
<Options>: A: ube2h (homo sapiens) (aka ubiquitin conjugating enzyme e2 h)
B: ubch5 (homo sapiens) (aka ubiquitin conjugating enzyme e2 d1)
C: ubc4 (glycine max) (aka ubiquitin carrier protein 4)
D: ubcm4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
E: ubch7 (homo sapiens) (aka ubi... | [I; B] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [e2-f1; p53; e6]
<Options>: A: e1 (human papillomavirus 16) (aka replication protein e1)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: e2-f1 (xenopus tropicalis) (aka ubiquitin conjugating enzyme e2 l3)
D: ct53 (homo sapiens) (aka zinc finger protein 165)
E: e2-f1 (homo sapiens) (aka ubiquitin conjug... | [P; G; N] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [e2-f1; p53; e6]
<Options>: A: transforming protein e7 (human papillomavirus 16) (aka transforming protein e7)
B: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
C: e1 (human papillomavirus 16) (aka replication protein e1)
D: hpve6a (homo sapiens) (aka ub... | [P; E; M] |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [e2-f1; p53; e6]
<Options>: A: e2-epf (homo sapiens) (aka ubiquitin conjugating enzyme e2 s)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: ube2f (gallus gallus) (aka ubiquitin conjugating enzyme e2 f (putative))
D: e1 (human papillomavirus 16) (aka replication protein e1)
E: ube2f (homo sapiens) (aka... | [P; O; M] |
<Instruct>: Given the context 'Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1.', select the correct biomedica... | <Mentions>: [autotaxin]
<Options>: A: autotaxina (xenopus tropicalis) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
D: t... | [B] |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain r... | <Mentions>: [autotaxin; pd-i alpha]
<Options>: A: pd-ialpha (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
C: pd1 (homo sapiens) (programmed cell death 1 (homo sapiens)) (aka programmed cell death 1)
D: autotaxin (homo sapien... | [D; K] |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain r... | <Mentions>: [autotaxin; pd-i alpha]
<Options>: A: pd-ialpha (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
C: pdcd1l... | [F; K] |
<Instruct>: Given the context 'Northern blot analysis of relative mRNA from multiple human tissues revealed that autotaxin mRNA steady state expression is most abundant in brain, placenta, ovary, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [autotaxin]
<Options>: A: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
B: transcriptional regulator atrx homolog (caenorhabditis elegans) (aka transcriptional regulator atrx homolog)
C: autotaxin (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
D: atx1 (arabidops... | [C] |
<Instruct>: Given the context 'Northern blot analysis of relative mRNA from multiple human tissues revealed that autotaxin mRNA steady state expression is most abundant in brain, placenta, ovary, and small intestine.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [autotaxin]
<Options>: A: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
B: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxi... | [E] |
<Instruct>: Given the context 'Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [osteoclast-specific 116-kda]
<Options>: A: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
B: transmembrane protein 116 (mus musculus) (aka transmembrane protein 116)
C: srh-116 (caenorhabditis elegans) (aka serpentine receptor, class h)
D: clec-116 (caenorhabditi... | [A] |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [116-kda polypeptide subunit of the osteoclastic proton pump; oc-116kda]
<Options>: A: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
B: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protei... | [C; C] |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer b... | <Mentions>: [116-kda polypeptide subunit of the osteoclastic proton pump; oc-116kda]
<Options>: A: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
B: v-atpase 116 kda (mus musculus) (aka atpase, h+ transporting, lysosomal v0 subunit a2)
C: vomeronasal type-2 receptor 116-l... | [A; A] |
<Instruct>: Given the context 'The predicted sequence of OC-116kDa consists of 822 amino acids and is 46.9% and 47.2% identical at the amino acid level to the 116-KDa polypeptide of the vacuolar proton pump of rat and bovine brain respectively.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [oc-116kda]
<Options>: A: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
B: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
C: vomeronasal type-2 receptor 116-like (oryctolagus cu... | [A] |
<Instruct>: Given the context 'OC-116KDa mRNA was found at high levels in osteoclastomas by Northern analysis but was not detected in tumor stromal cells or in other tissues including kidney, liver, skeletal muscle and brain.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [oc-116kda]
<Options>: A: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
B: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
C: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolag... | [A] |
<Instruct>: Given the context 'OC-116KDa mRNA was localized to multinucleated giant cells within the osteoclastoma tumor by in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [oc-116kda]
<Options>: A: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
B: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
C: ... | [D] |
<Instruct>: Given the context 'The ubiquitously expressed pICln protein forms homomeric complexes in vitro.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
B: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
C: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
D: methylosom... | [F] |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [icln; picln]
<Options>: A: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
B: icln (xenopus laevis) (chloride channel, nucleotide-sensitive, 1a l homeolog (xenopus laevis)) (aka chloride channel, nucleotide-sensitive, 1a l homeolog)
C: cdkn2a interacting protein n-terminal ... | [J; J] |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [icln; picln]
<Options>: A: icln (oryctolagus cuniculus) (aka chloride nucleotide-sensitive channel 1a)
B: pinin-like (xenopus tropicalis) (aka pinin-like)
C: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
D: icln (xenopus laevis) (chloride channel, nucleotide-sensitive... | [F; F] |
<Instruct>: Given the context 'We were therefore interested in whether pICln is involved in the endothelial volume-sensitive chloride current.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
B: cntln (homo sapiens) (aka centlein)
C: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
D: methylosome subunit picln-like (xenopus laevis) (aka me... | [F] |
<Instruct>: Given the context 'As a first step, we have cloned human pICln and studied its expression at the protein level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: picln (drosophila melanogaster) (aka icln)
B: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
C: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
D: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-lik... | [F] |
<Instruct>: Given the context 'Using a polyclonal antiserum raised against human pICln we found a widespread expression of pICln, both in endothelial cells and in other cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [picln]
<Options>: A: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
B: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
C: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
D: picln (drosophila melanogaster) (aka icl... | [F] |
<Instruct>: Given the context 'A characteristic feature of pICln is its anomalous migration during denaturing polyacrylamide gel electrophoresis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
B: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
C: cntln (homo sapiens) (aka centlein)
D: pinin-like (xenopus tropicalis) (aka pinin-like)
E: cdkn2a interacting protein n-termin... | [F] |
<Instruct>: Given the context 'We also demonstrate that bacterially expressed pICln forms homomeric complexes in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [picln]
<Options>: A: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
B: pinin-like (xenopus tropicalis) (aka pinin-like)
C: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
D: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a in... | [F] |
<Instruct>: Given the context 'Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vacuolar atpase (14-kda subunit)]
<Options>: A: atp6v1a (homo sapiens) (aka atpase h+ transporting v1 subunit a)
B: atp6alpha (homo sapiens) (aka activating transcription factor 6)
C: atp6s14 (homo sapiens) (aka atpase h+ transporting v1 subunit f)
D: atp12a (homo sapiens) (aka atpase h+/k+ transporting no... | [C] |
<Instruct>: Given the context 'A cDNA encoding the 14-kDa subunit of vacuolar ATPase was cloned from human fetal brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [14-kda subunit of vacuolar atpase]
<Options>: A: atp6s14-a (xenopus tropicalis) (aka atpase, h+ transporting, lysosomal 14kda, v1 subunit f)
B: atp1a4 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 4)
C: atp6alpha (homo sapiens) (aka activating transcription factor 6)
D: atp14 (candida albica... | [E] |
<Instruct>: Given the context 'A cDNA encoding the 14-kDa subunit of vacuolar ATPase was cloned from human fetal brain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [14-kda subunit of vacuolar atpase]
<Options>: A: atp14 (candida albicans sc5314) (aka f1f0 atp synthase subunit h)
B: atp6alpha (homo sapiens) (aka activating transcription factor 6)
C: atp6s14-a (xenopus tropicalis) (aka atpase, h+ transporting, lysosomal 14kda, v1 subunit f)
D: atp1a4 (homo sapiens) (aka... | [E] |
<Instruct>: Given the context 'Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [alkb]
<Options>: A: alk (homo sapiens) (aka alk receptor tyrosine kinase)
B: alk-1 (homo sapiens) (aka activin a receptor like type 1)
C: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
D: alkb (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
E: alk2 (homo sapiens) (aka activin a receptor ty... | [F] |
<Instruct>: Given the context 'The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS).', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [alkb]
<Options>: A: alk-1 (homo sapiens) (aka activin a receptor like type 1)
B: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
C: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, hist... | [F] |
<Instruct>: Given the context 'A human cDNA encoding a polypeptide homologous to E.coli AlkB was discovered by searching a database of expressed sequence tags (ESTs) derived from high throughput cDNA sequencing.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [alkb]
<Options>: A: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
B: alkb homolog 1, histone h2a dioxygenase (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
C: alk receptor tyrosine kinase (homo sapiens)... | [F] |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [alkb; habh]
<Options>: A: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
B: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
C: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dep... | [F; F] |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [alkb; habh]
<Options>: A: abhs (homo sapiens) (aka m-phase specific plk1 interacting protein)
B: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
C: alkb (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
D: h... | [C; C] |
<Instruct>: Given the context 'The hABH gene, which maps to chromosome 14q24, was ubiquitously expressed in 16 human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh]
<Options>: A: habp1 (homo sapiens) (aka complement c1q binding protein)
B: habon (homo sapiens) (aka bcl2 interacting protein 3)
C: abh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
D: habp (homo sapiens) (aka hyaluronan binding protein 2)
E: abhs (homo sapiens) (aka m-phase specific p... | [C] |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh; alkb]
<Options>: A: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
B: alk2 (homo sapiens) (aka activin a receptor type 1)
C: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
D: alk-1 (homo sapiens) (aka activin a receptor like type 1)
... | [H; K] |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh; alkb]
<Options>: A: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
B: alk2 (homo sapiens) (aka activin a receptor type 1)
C: alk-1 (homo sapiens) (aka activin a receptor like type 1)
D: habp1 (homo sapiens) (aka complement c1q binding protein)
E: alkb homolog 1, histone h2a dioxygenase (xenop... | [J; J] |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh; alkb]
<Options>: A: habh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
B: bah (homo sapiens) (aka aspartate beta-hydroxylase)
C: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dio... | [A; K] |
<Instruct>: Given the context 'Under the conditions used expression of hABH in skin fibroblasts was not regulated by treatment with MMS.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [habh]
<Options>: A: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
B: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
C: habp1 (homo sapiens) (aka complement c1q binding protein)
D: habon (homo sapiens) (aka bcl2 interacting protein 3)
E: abh1 (homo sapiens) (aka alkb homolog 1, histone h2... | [E] |
<Instruct>: Given the context 'Our findings show that the AlkB protein is structurally and functionally conserved from bacteria to human, but its regulation may have diverged during evolution.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [alkb]
<Options>: A: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
B: alk receptor tyrosine kinase (homo sapiens) (aka alk receptor tyrosine kinase)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 7 (homo sapiens) (aka alkb homolo... | [F] |
<Instruct>: Given the context 'Cloning and characterization of human urocortin.
Urocortin, a new member of the CRF peptide family which also includes urotensin I and sauvagine, was recently cloned from the rat midbrain.', select the correct biomedical concept for each mention using the provided options. Answer by listi... | <Mentions>: [urocortin]
<Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: urocortin (bos taurus) (aka urocortin)
C: ucn (homo sapiens) (aka urocortin)
D: urocortin (sus scrofa) (aka urocortin)
E: urocortin (rattus norvegicus) (aka urocortin)
F: None of the above. | [C] |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept for each menti... | <Mentions>: [urocortin; type 2 crf receptors]
<Options>: A: crf2x (homo sapiens) (aka interleukin 22 receptor subunit alpha 2)
B: urocortin (homo sapiens) (aka urocortin)
C: corticotropin releasing hormone receptor 2 (rattus norvegicus) (aka corticotropin releasing hormone receptor 2)
D: urocortin 3 (homo sapiens) (aka... | [B; G] |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept for each menti... | <Mentions>: [urocortin; type 2 crf receptors]
<Options>: A: urocortin (bos taurus) (aka urocortin)
B: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: urocortin (oryctolagus cuniculus) (aka urocortin)
D: crf-r 2 (rattus norvegicus) (aka corticotropin releasing hormone receptor 2)
E: urocortin (x... | [G; J] |
<Instruct>: Given the context 'Using a genomic library, we have cloned the human counterpart of rat urocortin and localized it to human chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (rattus norvegicus) (aka urocortin)
B: urocortin (sus scrofa) (aka urocortin)
C: urocortin (homo sapiens) (aka urocortin)
D: urocortin (xenopus tropicalis) (aka urocortin)
E: urocortin 3 (homo sapiens) (aka urocortin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'Using a genomic library, we have cloned the human counterpart of rat urocortin and localized it to human chromosome 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (sus scrofa) (aka urocortin)
B: urocortin (xenopus tropicalis) (aka urocortin)
C: urocortin 3 (homo sapiens) (aka urocortin 3)
D: urocortin (rattus norvegicus) (aka urocortin)
E: None of the above. | [E] |
<Instruct>: Given the context 'Human and rat urocortin share 95% identity within the mature peptide region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [urocortin]
<Options>: A: urocortin (rattus norvegicus) (aka urocortin)
B: urocortin (sus scrofa) (aka urocortin)
C: urocortin (homo sapiens) (aka urocortin)
D: urocortin (xenopus tropicalis) (aka urocortin)
E: urocortin (bos taurus) (aka urocortin)
F: None of the above. | [C] |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical ... | <Mentions>: [urocortin; acth]
<Options>: A: ucn (homo sapiens) (aka urocortin)
B: urocortin (oryctolagus cuniculus) (aka urocortin)
C: urocortin 2 (homo sapiens) (aka urocortin 2)
D: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
E: urocortin (sus scrofa) (aka urocortin)
F: uro... | [A; G] |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical ... | <Mentions>: [urocortin; acth]
<Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: urocortin (homo sapiens) (aka urocortin)
C: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
D: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
E: urocortin (xenopus tropicalis) (aka ... | [B; G] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: pomc (homo sapiens) (aka proopiomelanocortin)
B: crh (homo sapiens) (aka corticotropin releasing hormone)
C: ucn (homo sapiens) (aka urocortin)
D: corticotropin releasing hormone binding protein (bos taurus) (aka corticotropin releasing hormone binding pr... | [G; C; A] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: acth1 (rattus norvegicus) (aka proopiomelanocortin)
B: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
D: urocortin (oryctolagus cuniculus) (aka... | [F; N; H] |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [crf-binding protein; urocortin; acth]
<Options>: A: acth1 (rattus norvegicus) (aka proopiomelanocortin)
B: acthr (homo sapiens) (aka melanocortin 2 receptor)
C: urocortin 2 (homo sapiens) (aka urocortin 2)
D: urocortin (rattus norvegicus) (aka urocortin)
E: crf-rb (homo sapiens) (aka corticotropin releasin... | [M; L; K] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
B: crfbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
C: crfbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
D: urocort... | [B; J; A] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: urocortin 3 (homo sapiens) (aka urocortin 3)
B: ucn (homo sapiens) (aka urocortin)
C: crf (homo sapiens) (aka complement c1q like 1)
D: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
E: urocortin 2 (homo sapiens) (aka ... | [H; B; D] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: urocortin 3 (homo sapiens) (aka urocortin 3)
B: urocortin (oryctolagus cuniculus) (aka urocortin)
C: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
D: corticotropin releasing hormone binding protein (bos taurus) (aka cortic... | [N; L; I] |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [crf-binding protein; urocortin; crf]
<Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: crf-r-1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: crf1 (homo sapiens) (corticotropin releasing hormone (homo sapiens)) (aka corticotropin releasing hormone)
D: ucn (homo sapiens) (aka... | [G; D; C] |
<Instruct>: Given the context 'Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [brain-specific na(+)-dependent inorganic phosphate cotransporter]
<Options>: A: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
B: inorganic phosphate transporter 1-1 (glycine max) (aka inorganic phosphate transporter 1-1)
C: npt1 (homo sapiens) (aka solute carrier family 17 member 1)
D: na[+... | [A] |
<Instruct>: Given the context 'We describe the molecular cloning of a cDNA encoding a human brain Na(+)-dependent inorganic phosphate (P(i)) cotransporter (hBNPI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [brain na(+)-dependent inorganic phosphate (p(i)) cotransporter; hbnpi]
<Options>: A: vglut1 (homo sapiens) (aka solute carrier family 17 member 7)
B: inorganic phosphate transporter 1-1 (glycine max) (aka inorganic phosphate transporter 1-1)
C: impnb (homo sapiens) (aka karyopherin subunit beta 1)
D: npt-1... | [A; A] |
<Instruct>: Given the context 'We describe the molecular cloning of a cDNA encoding a human brain Na(+)-dependent inorganic phosphate (P(i)) cotransporter (hBNPI).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [brain na(+)-dependent inorganic phosphate (p(i)) cotransporter; hbnpi]
<Options>: A: pni (homo sapiens) (aka serpin family e member 2)
B: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
C: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
D: vglut1 (homo sapiens) (aka solute carrier family 17 memb... | [D; D] |
<Instruct>: Given the context 'The nucleotide and deduced amino acid sequences of hBNPI reveal a protein of 560 amino acids with six to eight putative transmembrane segments.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [hbnpi]
<Options>: A: npb (homo sapiens) (aka neuropeptide b)
B: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
C: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
D: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
E: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin t... | [B] |
<Instruct>: Given the context 'hBNPI shares a high degree of homology with other Na(+)-dependent inorganic P(i) cotransporters, including those found in rat brain and human and rabbit kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [hbnpi]
<Options>: A: pni (homo sapiens) (aka serpin family e member 2)
B: impnb (homo sapiens) (aka karyopherin subunit beta 1)
C: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
D: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
E: hbi (homo s... | [C] |
<Instruct>: Given the context 'hBNPI shares a high degree of homology with other Na(+)-dependent inorganic P(i) cotransporters, including those found in rat brain and human and rabbit kidney.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [hbnpi]
<Options>: A: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
B: impnb (homo sapiens) (aka karyopherin subunit beta 1)
C: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
D: pni (homo sapiens) (aka serpin family e member 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'Expression of hBNPI in COS-1 cells results in Na(+)-dependent P(i) uptake.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hbnpi]
<Options>: A: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
B: impnb (homo sapiens) (aka karyopherin subunit beta 1)
C: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
D: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
E: nppb (homo s... | [A] |
<Instruct>: Given the context 'Northern blot analysis demonstrates that hBNPI mRNA is expressed predominantly in brain and most abundantly in neuron-enriched regions such as the amygdala and hippocampus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [hbnpi]
<Options>: A: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
B: pni (homo sapiens) (aka serpin family e member 2)
C: impnb (homo sapiens) (aka karyopherin subunit beta 1)
D: npipb1p (homo sapiens) (aka nuclear pore complex interacting protein family member b1, pseudogene)
E: bnpi (homo sapiens) (a... | [E] |
<Instruct>: Given the context 'In situ hybridization histochemistry reveals relatively high levels of hBNPI mRNA in pyramidal neurons of the cerebral cortex and hippocampus and in granule neurons of dentate gyrus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [hbnpi]
<Options>: A: pni (homo sapiens) (aka serpin family e member 2)
B: nppb (homo sapiens) (aka natriuretic peptide b)
C: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
D: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
E: impnb (homo sapiens) (aka karyophe... | [C] |
<Instruct>: Given the context 'The level of hBNPI mRNA is quite low in fetal compared with adult human brain, suggesting developmental regulation of hBNPI gene expression.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [hbnpi]
<Options>: A: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
B: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
C: impnb (homo sapiens) (aka karyopherin subunit beta 1)
D: pni (homo sapiens) (aka serpin family e member 2)
E: pnpi (homo sapiens) (aka adam metallopeptidase with ... | [A] |
<Instruct>: Given the context 'Southern analyses of nine eukaryotic genomic DNAs probed under stringent conditions with hBNPI cDNA revealed that the hBNPI gene is highly conserved during vertebrate evolution and that each gene is most likely present as a single copy.', select the correct biomedical concept for each men... | <Mentions>: [hbnpi]
<Options>: A: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
B: nppb (homo sapiens) (aka natriuretic peptide b)
C: hbi (homo sapiens) (aka fkbp prolyl isomerase 4)
D: npb (homo sapiens) (aka neuropeptide b)
E: bnpi (homo sapiens) (aka solute carrier family 17 membe... | [E] |
<Instruct>: Given the context 'Using fluorescent in situ hybridization, we localized hBNPI to the long arm of chromosome 19 (19q13) in close proximity to the late-onset familial Alzheimer's disease locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [hbnpi]
<Options>: A: bnpi (homo sapiens) (aka solute carrier family 17 member 7)
B: npi (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 2)
C: impnb (homo sapiens) (aka karyopherin subunit beta 1)
D: nprbi (homo sapiens) (aka natriuretic peptide receptor 2)
E: nppb (homo sapiens) ... | [A] |
<Instruct>: Given the context 'In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.
Rab8 is a small GTP-binding protein that plays a role in vesicular transport from the trans-Golgi network to the basolateral plasma membrane in polarized epithelial cells (MDCK), and to the ... | <Mentions>: [rab8]
<Options>: A: mel (homo sapiens) (rab8a, member ras oncogene family (homo sapiens)) (aka rab8a, member ras oncogene family)
B: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
C: rabin8 (homo sapiens) (aka rab3a interacting protein)
D: rab8b, member ras oncogen... | [A] |
<Instruct>: Given the context 'As is the case for most other rab proteins, the precise molecular interactions by which rab8 carries out its function remain to be elucidated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [rab8]
<Options>: A: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
B: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
C: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
D: rab8 (droso... | [E] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
B: rab8a, member ras oncogene family l homeolog (xenopus laevis) (aka rab8a, member ras oncogene family l homeolog)
C: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras... | [J; J; M] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
B: mel (homo sapiens) (rab8a, member ras oncogene family (homo sapiens)) (aka rab8a, member ras oncogene family)
C: rab8 (drosophila melanogaster) (aka rab8)
D: prkm8ip (homo sapiens) (aka m... | [G; G; B] |
<Instruct>: Given the context 'Here we report the identification and the complete cDNA-derived amino acid sequence of a murine rab8-interacting protein (rab8ip) that specifically interacts with rab8 in a GTP-dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [rab8-interacting protein; rab8ip; rab8]
<Options>: A: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
B: mel (homo sapiens) (rab8a, member ras oncogene family (homo sapiens)) (aka rab8a, member ras oncogene family)
C: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene f... | [F; F; B] |
<Instruct>: Given the context 'Rab8ip displays 93% identity with the GC kinase, a serine/threonine protein kinase recently identified in human lymphoid tissue that is activated in the stress response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [rab8ip; gc kinase]
<Options>: A: eif-2-alpha kinase gcn2 (glycine max) (aka eif-2-alpha kinase gcn2)
B: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
C: rab3a interacting protein (homo sapiens) (aka rab3a interacting protein)
D: gck-1 (caen... | [J; I] |
<Instruct>: Given the context 'Rab8ip displays 93% identity with the GC kinase, a serine/threonine protein kinase recently identified in human lymphoid tissue that is activated in the stress response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [rab8ip; gc kinase]
<Options>: A: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
C: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase ki... | [A; C] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
B: rabin8 (homo sapiens) (aka rab3a interacting protein)
C: myelin basic protein (sus scrofa) (aka myelin basic protein)
D: myelin-associated oligodendrocytic basic protein (mus m... | [M; F; N] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: rab3ip (homo sapiens) (aka rab3a interacting protein)
B: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
C: rab5ip (homo sapiens) (aka sad1 and unc84 domain containing 2)
D: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (... | [I; N; F] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: myelin basic protein (xenopus tropicalis) (aka myelin basic protein)
B: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
C: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
D: rab8ipl1 (homo sapiens) (aka mitogen-activated pr... | [J; M; E] |
<Instruct>: Given the context 'Like the GC kinase, rab8ip has protein kinase activity manifested by autophosphorylation and phosphorylation of the classical serine/threonine protein kinase substrates, myelin basic protein and casein.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [gc kinase; rab8ip; myelin basic protein]
<Options>: A: gck-2 (caenorhabditis elegans) (aka mitogen-activated protein kinase kinase kinase kinase)
B: gck (xenopus laevis) (aka glucokinase (hexokinase 4) l homeolog)
C: mbp (mus musculus) (myelin basic protein (mus musculus)) (aka myelin basic protein)
D: rab... | [H; O; K] |
<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab8ip (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
C: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
... | [O; L; M] |
<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: mel (homo sapiens) (rab8a, member ras oncogene family (homo sapiens)) (aka rab8a, member ras oncogene family)
B: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C... | [A; G; B] |
<Instruct>: Given the context 'When coexpressed in transfected 293T cells, rab8 and the rab8ip/GC kinase formed a complex that could be recovered by immunoprecipitation with antibodies to rab8.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab28, member ras oncogene family (homo sapiens) (aka rab28, member ras oncogene family)
B: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C: gnk (homo sapiens) ... | [K; O; B] |
<Instruct>: Given the context 'Cell fractionation and immunofluorescence analyses indicate that in MDCK cells endogenous rab8ip is present both in the cytosol and as a peripheral membrane protein concentrated in the Golgi region and basolateral plasma membrane domains, sites where rab8 itself is also located.', select ... | <Mentions>: [rab8ip; rab8]
<Options>: A: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
B: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C: rab8 (drosophila melanogaster) (aka rab8)
D: mcm8ip (homo sapiens) (aka homologous recombination fac... | [B; E] |
<Instruct>: Given the context 'Cell fractionation and immunofluorescence analyses indicate that in MDCK cells endogenous rab8ip is present both in the cytosol and as a peripheral membrane protein concentrated in the Golgi region and basolateral plasma membrane domains, sites where rab8 itself is also located.', select ... | <Mentions>: [rab8ip; rab8]
<Options>: A: rab8 (drosophila melanogaster) (aka rab8)
B: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
C: mcm8ip (homo sapiens) (aka homologous recombination factor with ob-fold)
D: rab28, member ras oncogene family (homo sapiens) (aka rab28, member r... | [G; H] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab8 (drosophila melanogaster) (aka rab8)
B: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
C: rabin8 (homo sapiens) (aka rab3a interacting protein)
D: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
E: gnk (homo sapien... | [K; L; J] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
B: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
C: gnk (homo sapiens) (aka n-acetylglucosamine kinase)
D: rabin8 (ho... | [L; B; J] |
<Instruct>: Given the context 'In light of recent evidence that rab proteins may act by promoting the stabilization of SNARE complexes, the specific GTP-dependent association of rab8 with the rab8ip/GC kinase raises the possibility that rab-regulated protein phosphorylation is important for vesicle targeting or fusion.... | <Mentions>: [rab8; rab8ip; gc kinase]
<Options>: A: rab8b, member ras oncogene family (homo sapiens) (aka rab8b, member ras oncogene family)
B: rab8a (homo sapiens) (aka rab8a, member ras oncogene family)
C: rab8a, member ras oncogene family (mus musculus) (aka rab8a, member ras oncogene family)
D: gck (homo sapiens) (... | [B; I; G] |
<Instruct>: Given the context 'Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: gck (homo sapiens) (mitogen-activated protein kinase kinase kinase kinase 2 (homo sapiens)) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: prkm8ip (homo sapiens) (aka mitogen-activated protein kinase 8 interacting protein 1)
C: gck (homo sapiens) (glucokin... | [J; A] |
<Instruct>: Given the context 'Moreover, the rab8ip/GC kinase may serve to modulate secretion in response to stress stimuli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab8ip; gc kinase]
<Options>: A: rab8ip (mus musculus) (aka mitogen-activated protein kinase kinase kinase kinase 2)
B: rab6ip1 (homo sapiens) (aka denn domain containing 5a)
C: serine/threonine-protein kinase gcn2 (saccharomyces cerevisiae s288c) (aka serine/threonine-protein kinase gcn2)
D: rab8ipl1 (hom... | [A; H] |
<Instruct>: Given the context 'The contribution of the two transporter isoforms to monoamine storage in human neuroendocrine tissues was examined with isoform-specific polyclonal antibodies against hVMAT1 and hVMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: solute carrier family 18 (vesicular monoamine), member 1 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 1)
B: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
C: amino acid transporter avt1j-like (glycine max) (aka amino acid transporte... | [B; J] |
<Instruct>: Given the context 'The contribution of the two transporter isoforms to monoamine storage in human neuroendocrine tissues was examined with isoform-specific polyclonal antibodies against hVMAT1 and hVMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: n6amt1 (homo sapiens) (aka hemk methyltransferase 2, etf1 glutamine and histone h4 lysine)
B: n6amt2 (homo sapiens) (aka eef1a lysine methyltransferase 1)
C: amino acid transporter avt1j-like (glycine max) (aka amino acid transporter avt1j-like)
D: solute carrier family 3 (act... | [E; I] |
<Instruct>: Given the context 'The contribution of the two transporter isoforms to monoamine storage in human neuroendocrine tissues was examined with isoform-specific polyclonal antibodies against hVMAT1 and hVMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: maat1 (homo sapiens) (aka mitochondrial ribosomal protein l28)
B: hvmt1 (mus musculus) (aka heavy metal tolerance protein 1)
C: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
D: amino acid transporter avt1j-like (glycine max) (aka amino acid transporter avt1j-lik... | [J; C] |
<Instruct>: Given the context 'Central, peripheral, and enteric neurons express only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
B: slc6a2 (homo sapiens) (aka solute carrier family 6 member 2)
C: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
D: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
E: solute carrier family 18 (ve... | [D] |
<Instruct>: Given the context 'VMAT1 is expressed exclusively in neuroendocrine, including chromaffin and enterochromaffin, cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1]
<Options>: A: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
B: vesicle amine transport 1 (homo sapiens) (aka vesicle amine transport 1)
C: vat1 (homo sapiens) (solute carrier family 18 member a1 (homo sapiens)) (aka solute carrier family 18 member a1)
D: vmat2 (homo sapiens) (a... | [C] |
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