instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'VMAT1 and VMAT2 are coexpressed in all chromaffin cells of the adrenal medulla.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1; vmat2]
<Options>: A: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
B: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
C: viaat (homo sapiens) (aka solute carrier family 32 member 1)
D: vesicle amine transport 1 (homo sapiens) (aka vesicle amine transport 1)
E: vat2 (hom... | [I; E] |
<Instruct>: Given the context 'VMAT1 and VMAT2 are coexpressed in all chromaffin cells of the adrenal medulla.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat1; vmat2]
<Options>: A: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
B: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
C: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
D: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
E: solute carrier f... | [H; D] |
<Instruct>: Given the context 'VMAT2 alone is expressed in histamine-storing enterochromaffin-like cells of the oxyntic mucosa of the stomach.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: vmat2 (rattus norvegicus) (aka solute carrier family 18 member a2)
B: solute carrier family 18 (vesicular monoamine), member 2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
C: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
D: slc6a2 (homo ... | [E] |
<Instruct>: Given the context 'Catecholamines exhibit a 3-fold higher affinity, and histamine exhibits a 30-fold higher affinity, for VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmat2]
<Options>: A: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
B: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
C: vmat2 (rattus norvegicus) (aka solute carrier family 18 member a2)
D: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
E: vat2 (homo sapiens) (ak... | [E] |
<Instruct>: Given the context 'Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [vmat2; vmat1]
<Options>: A: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
B: vmat2 (homo sapiens) (aka solute carrier family 18 member a2)
C: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
D: viaat (homo sapiens) (aka solute carrier family 32 member 1)
E: vesicle amine ... | [B; A] |
<Instruct>: Given the context 'Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [vmat2; vmat1]
<Options>: A: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
B: vglut2 (homo sapiens) (aka solute carrier family 17 member 6)
C: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
D: viaat (homo sapiens) (aka solute carrier family 32 member 1)
E: vmat2 (mus mus... | [H; C] |
<Instruct>: Given the context 'Reserpine and ketanserin are slightly more potent inhibitors of VMAT2-mediated transport than of VMAT1-mediated transport, whereas tetrabenazine binds to and inhibits only VMAT2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [vmat2; vmat1]
<Options>: A: solute carrier family 18 (vesicular monoamine), member 1 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 1)
B: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
C: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
D: vglut2 (homo ... | [I; C] |
<Instruct>: Given the context 'N-methyl-4-phenylpyridinium, phenylethylamine, amphetamine, and methylenedioxymethamphetamine are all more potent inhibitors of VMAT2 than of VMAT1, whereas fenfluramine is a more potent inhibitor of VMAT1-mediated monamine transport than of VMAT2-mediated monoamine transport.', select th... | <Mentions>: [vmat2; vmat1]
<Options>: A: viaat (homo sapiens) (aka solute carrier family 32 member 1)
B: slc18a1 (homo sapiens) (aka solute carrier family 18 member a1)
C: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a1)
D: slc6a2 (homo sapiens) (aka solute carrier family 6 member 2)
E: vat2 (homo sa... | [E; B] |
<Instruct>: Given the context 'N-methyl-4-phenylpyridinium, phenylethylamine, amphetamine, and methylenedioxymethamphetamine are all more potent inhibitors of VMAT2 than of VMAT1, whereas fenfluramine is a more potent inhibitor of VMAT1-mediated monamine transport than of VMAT2-mediated monoamine transport.', select th... | <Mentions>: [vmat2; vmat1]
<Options>: A: vmat2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
B: eaat2 (homo sapiens) (aka solute carrier family 1 member 2)
C: viaat (homo sapiens) (aka solute carrier family 32 member 1)
D: vmat-1 (rattus norvegicus) (aka solute carrier family 18 member a... | [E; F] |
<Instruct>: Given the context 'The unique distributions of hVMAT1 and hVMAT2 provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous syste... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: vmat-2 (rattus norvegicus) (aka solute carrier family 18 member a2)
B: vstm2 (homo sapiens) (aka v-set and transmembrane domain containing 2a)
C: vat2 (homo sapiens) (aka solute carrier family 18 member a2)
D: n6amt2 (homo sapiens) (aka eef1a lysine methyltransferase 1)
E: avt... | [F; C] |
<Instruct>: Given the context 'The unique distributions of hVMAT1 and hVMAT2 provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous syste... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: amino acid transporter avt1j (glycine max) (aka amino acid transporter avt1j)
B: vmat1 (homo sapiens) (aka solute carrier family 18 member a1)
C: vmat2 (mus musculus) (aka solute carrier family 18 (vesicular monoamine), member 2)
D: n6amt2 (homo sapiens) (aka eef1a lysine meth... | [B; E] |
<Instruct>: Given the context 'The unique distributions of hVMAT1 and hVMAT2 provide new markers for multiple neuroendocrine lineages, and examination of their transport properties provides mechanistic insights into the pharmacology and physiology of amine storage in cardiovascular, endocrine, and central nervous syste... | <Mentions>: [hvmat1; hvmat2]
<Options>: A: amino acid transporter avt1j-like (glycine max) (aka amino acid transporter avt1j-like)
B: hvmt1 (mus musculus) (aka heavy metal tolerance protein 1)
C: n6amt2 (homo sapiens) (aka eef1a lysine methyltransferase 1)
D: solute carrier family 3 (activators of dibasic and neutral a... | [J; F] |
<Instruct>: Given the context 'The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c/ebpalpha; ob]
<Options>: A: ccaat enhancer binding protein alpha (xenopus tropicalis) (aka ccaat enhancer binding protein alpha)
B: c/ebp-alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
C: obf (homo sapiens) (aka izumo sperm-oocyte fusion 1)
D: c/ebp-beta (homo sapiens) (aka ccaat enhance... | [B; F] |
<Instruct>: Given the context 'The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [c/ebpalpha; ob]
<Options>: A: obv (drosophila melanogaster) (aka centrosomin)
B: leptin (homo sapiens) (aka leptin)
C: ccaat enhancer binding protein beta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
D: c/ebp-alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
E: ob1 (gallus g... | [D; B] |
<Instruct>: Given the context 'The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [ob; leptin]
<Options>: A: ob (drosophila melanogaster) (aka oblique)
B: lepr (homo sapiens) (leptin receptor (homo sapiens)) (aka leptin receptor)
C: leptin (gallus gallus) (aka leptin)
D: obp-1 (homo sapiens) (aka kinesin family member 22)
E: leptin (homo sapiens) (aka leptin)
F: lepr (homo sapiens) (lept... | [E; E] |
<Instruct>: Given the context 'The ob gene product, leptin, apparently exclusively expressed in adipose tissue, is a signaling factor regulating body weight homeostasis and energy balance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one fo... | <Mentions>: [ob; leptin]
<Options>: A: obp (drosophila melanogaster) (aka optix-binding protein)
B: leptin receptor (homo sapiens) (aka leptin receptor)
C: ob (drosophila melanogaster) (aka oblique)
D: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
E: obr (homo sapiens) (aka leptin receptor)
F: leptin (gallus g... | [D; D] |
<Instruct>: Given the context 'ob gene expression is increased in obese rodents and regulated by feeding, insulin, and glucocorticoids, which supports the concept that ob gene expression is under hormonal control, which is expected for a key factor controlling body weight homeostasis and energy balance.', select the co... | <Mentions>: [ob]
<Options>: A: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
B: obp-1 (homo sapiens) (aka kinesin family member 22)
C: obf (homo sapiens) (aka izumo sperm-oocyte fusion 1)
D: obp (drosophila melanogaster) (aka optix-binding protein)
E: obv (drosophila melanogaster) (aka centrosomin)
F: None of ... | [A] |
<Instruct>: Given the context 'In humans, ob mRNA expression is increased in gross obesity; however, the effects of the above factors on human ob expression are unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [ob]
<Options>: A: ob1 (gallus gallus) (aka hop homeobox)
B: ob (drosophila melanogaster) (aka oblique)
C: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
D: obr (homo sapiens) (aka leptin receptor)
E: obp (drosophila melanogaster) (aka optix-binding protein)
F: None of the above. | [C] |
<Instruct>: Given the context 'In humans, ob mRNA expression is increased in gross obesity; however, the effects of the above factors on human ob expression are unknown.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [ob]
<Options>: A: obr (homo sapiens) (aka leptin receptor)
B: obp (drosophila melanogaster) (aka optix-binding protein)
C: ob (drosophila melanogaster) (aka oblique)
D: ob1 (gallus gallus) (aka hop homeobox)
E: None of the above. | [E] |
<Instruct>: Given the context 'We describe the structure of the human ob gene and initial functional analysis of its promoter.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ob]
<Options>: A: ob1 (gallus gallus) (aka hop homeobox)
B: obf (homo sapiens) (aka izumo sperm-oocyte fusion 1)
C: obp-1 (homo sapiens) (aka kinesin family member 22)
D: obp (drosophila melanogaster) (aka optix-binding protein)
E: leptin (homo sapiens) (aka leptin)
F: None of the above. | [E] |
<Instruct>: Given the context 'The human ob gene's three exons cover approximately 15 kb of genomic DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ob]
<Options>: A: obv (drosophila melanogaster) (aka centrosomin)
B: ob (drosophila melanogaster) (aka oblique)
C: ob (oryctolagus cuniculus) (aka leptin)
D: leptin (homo sapiens) (aka leptin)
E: obp-1 (homo sapiens) (aka kinesin family member 22)
F: None of the above. | [D] |
<Instruct>: Given the context 'Only 217 bp of 5' sequence are required for basal adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [ob; c/ebpalpha]
<Options>: A: obp-1 (homo sapiens) (aka kinesin family member 22)
B: ob (oryctolagus cuniculus) (aka leptin)
C: ob (drosophila melanogaster) (aka oblique)
D: c/ebp-alpha (xenopus tropicalis) (aka ccaat enhancer binding protein alpha)
E: ob1 (gallus gallus) (aka hop homeobox)
F: ob (homo sap... | [F; H] |
<Instruct>: Given the context 'Only 217 bp of 5' sequence are required for basal adipose tissue-specific expression of the ob gene as well as enhanced expression by C/EBPalpha.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [ob; c/ebpalpha]
<Options>: A: ob (oryctolagus cuniculus) (aka leptin)
B: c/ebp-alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
C: obp (drosophila melanogaster) (aka optix-binding protein)
D: c/ebp-beta (homo sapiens) (aka ccaat enhancer binding protein beta)
E: leptin (homo sapiens) (aka le... | [E; B] |
<Instruct>: Given the context 'Mutation of the single C/EBPalpha site in this region abolished inducibility of the promoter by C/EBPalpha in cotransfection assays.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [c/ebpalpha]
<Options>: A: c/ebpbeta (xenopus tropicalis) (aka ccaat enhancer binding protein beta)
B: ccaat enhancer binding protein alpha (homo sapiens) (aka ccaat enhancer binding protein alpha)
C: c/ebp (xenopus tropicalis) (aka ccaat enhancer binding protein alpha)
D: c/ebp-beta (homo sapiens) (aka cca... | [B] |
<Instruct>: Given the context 'The gene structure will facilitate our analysis of ob mutations in human obesity, whereas knowledge of sequence elements and factors regulating ob gene expression should be of major importance in the prevention and treatment of obesity.', select the correct biomedical concept for each men... | <Mentions>: [ob]
<Options>: A: ob (drosophila melanogaster) (aka oblique)
B: obr (homo sapiens) (aka leptin receptor)
C: obv (drosophila melanogaster) (aka centrosomin)
D: obp (drosophila melanogaster) (aka optix-binding protein)
E: ob (homo sapiens) (leptin (homo sapiens)) (aka leptin)
F: None of the above. | [E] |
<Instruct>: Given the context 'Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ara70; androgen receptor]
<Options>: A: nr5a1 (homo sapiens) (aka nuclear receptor subfamily 5 group a member 1)
B: arc100 (homo sapiens) (aka mediator complex subunit 24)
C: thra (homo sapiens) (aka thyroid hormone receptor alpha)
D: ara160 (homo sapiens) (aka tata element modulatory factor 1)
E: ra70 (ho... | [G; I] |
<Instruct>: Given the context 'Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ara70; androgen receptor]
<Options>: A: thra1 (homo sapiens) (aka nuclear receptor subfamily 1 group d member 1)
B: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
C: ara70 (xenopus tropicalis) (aka nuclear receptor coactivator 4)
D: arc100 (homo sapiens) (aka mediator complex subunit 24)
... | [G; J] |
<Instruct>: Given the context 'Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ara70; androgen receptor]
<Options>: A: ara70 (homo sapiens) (aka nuclear receptor coactivator 4)
B: androgen receptor (homo sapiens) (aka androgen receptor)
C: arc100 (homo sapiens) (aka mediator complex subunit 24)
D: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
E: ara160 (homo sapien... | [A; B] |
<Instruct>: Given the context 'The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [androgen receptor; ar]
<Options>: A: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
B: retinoid x receptor alpha (homo sapiens) (aka retinoid x receptor alpha)
C: ager (homo sapiens) (aka advanced glycosylation end-product specific receptor)
... | [F; F] |
<Instruct>: Given the context 'The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [androgen receptor; ar]
<Options>: A: anr1 (arabidopsis thaliana) (aka agamous-like 44)
B: c-erba-1 (homo sapiens) (aka thyroid hormone receptor alpha)
C: androgen receptor (rattus norvegicus) (aka androgen receptor)
D: retinoid x receptor alpha (homo sapiens) (aka retinoid x receptor alpha)
E: ager1 (homo ... | [F; F] |
<Instruct>: Given the context 'Mutations or abnormal expression of AR in prostate cancer can play a key role in the process that changes prostate cancer from androgen-dependent to an androgen-independent stage.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [ar]
<Options>: A: androgen receptor (homo sapiens) (aka androgen receptor)
B: ar1 (homo sapiens) (aka transcription factor 20)
C: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
D: anr1 (arabidopsis thaliana) (aka agamous-like 44)
E: ar (droso... | [A] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: ligand of ate1 (homo sapiens) (aka ligand of ate1)
B: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
C: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
D: ara70... | [O; O; F] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: ager (homo sapiens) (aka advanced glycosylation end-product specific receptor)
B: rpa70 (homo sapiens) (aka replication protein a1)
C: ara70 (xenopus tropicalis) (aka nuclear receptor coactivator 4)
D: ar1 (homo sapiens) (aka transcription fa... | [O; O; I] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: ar (homo sapiens) (androgen receptor (homo sapiens)) (aka androgen receptor)
B: nuclear receptor 2c2 associated protein (homo sapiens) (aka nuclear receptor 2c2 associated protein)
C: nuclear receptor 2c2-associated protein (xenopus tropicali... | [G; G; A] |
<Instruct>: Given the context 'Using a yeast two-hybrid system, we were able to isolate a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10)', select the correct biomedical concept for each mention using the provided ... | <Mentions>: [ligand-dependent ar-associated protein; ara70; ar]
<Options>: A: steroid receptor associated and regulated protein (homo sapiens) (aka steroid receptor associated and regulated protein)
B: nuclear receptor 2c2 associated protein (homo sapiens) (aka nuclear receptor 2c2 associated protein)
C: ar (rattus nor... | [M; M; L] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: rpa70 (xenopus laevis) (replication protein a1 s homeolog (xenopus laevis)) (aka replication protein a1 s homeolog)
B: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
C: progesteron... | [N; L; G] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: ara160 (homo sapiens) (aka tata element modulatory factor 1)
B: ara70 (xenopus laevis) (nuclear receptor coactivator 4 s homeolog (xenopus laevis)) (aka nuclear receptor coactivator 4 s homeolog)
C: rpa70 (xenopus laevis) (replication pro... | [H; D; G] |
<Instruct>: Given the context 'Our data further indicated that ARA70 Will only slightly induce the transcriptional activity of other steroid receptors such as estrogen receptor, glucocorticoid receptor, and progesterone receptor in DU145 cells.', select the correct biomedical concept for each mention using the provided... | <Mentions>: [ara70; glucocorticoid receptor; progesterone receptor]
<Options>: A: progesterone receptor (gallus gallus) (aka progesterone receptor)
B: pgr (xenopus laevis) (progesterone receptor s homeolog (xenopus laevis)) (aka progesterone receptor s homeolog)
C: pr (homo sapiens) (progesterone receptor (homo sapiens... | [J; K; C] |
<Instruct>: Given the context 'Together, these data suggest that AR may need a specific coactivator(s) such as ARA70 for optimal androgen activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ar; ara70]
<Options>: A: ra70 (homo sapiens) (aka src kinase associated phosphoprotein 2)
B: arc100 (homo sapiens) (aka mediator complex subunit 24)
C: androgen receptor repeat instability region (homo sapiens) (aka androgen receptor repeat instability region)
D: ar1 (arabidopsis thaliana) (aka p450 reduct... | [G; J] |
<Instruct>: Given the context 'Together, these data suggest that AR may need a specific coactivator(s) such as ARA70 for optimal androgen activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ar; ara70]
<Options>: A: ager1 (homo sapiens) (aka dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
B: ara70 (homo sapiens) (aka nuclear receptor coactivator 4)
C: androgen receptor (homo sapiens) (aka androgen receptor)
D: arc100 (homo sapiens) (aka mediator complex su... | [C; B] |
<Instruct>: Given the context 'Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [evi1]
<Options>: A: evi (homo sapiens) (aka wnt ligand secretion mediator)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: eve-1 (homo sapiens) (aka sh3 domain containing 19)
D: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
E: evi3 (homo sapiens) (aka zinc finger protein 521)
F: ... | [D] |
<Instruct>: Given the context 'Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [evi1]
<Options>: A: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
B: evi (homo sapiens) (aka wnt ligand secretion mediator)
C: eve-1 (homo sapiens) (aka sh3 domain containing 19)
D: evi3 (homo sapiens) (aka zinc finger protein 521)
E: None of the above. | [E] |
<Instruct>: Given the context 'The EVI1 gene, located at chromosome band 3q26, is overexpressed in some myeloid leukemia patients with breakpoints either 5' of the gene in the t(3;3)(q21;q26) or 3' of the gene in the inv(3)(q21q26).', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [evi1]
<Options>: A: evi (homo sapiens) (aka wnt ligand secretion mediator)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
D: evi-1 (homo sapiens) (aka runx family transcriptio... | [E] |
<Instruct>: Given the context 'EVI1 is also expressed as part of a fusion transcript with the transcription factor AML1 in the t(3;21)(q26;q22), associated with myeloid leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [evi1; aml1]
<Options>: A: aml2 (homo sapiens) (aka runx family transcription factor 3)
B: evin1 (homo sapiens) (aka transmembrane channel like 6)
C: aml1t1 (homo sapiens) (aka runx1 partner transcriptional co-repressor 1)
D: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
E: eve-1 (homo sapiens) (aka... | [D; J] |
<Instruct>: Given the context 'EVI1 is also expressed as part of a fusion transcript with the transcription factor AML1 in the t(3;21)(q26;q22), associated with myeloid leukemia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [evi1; aml1]
<Options>: A: aml3 (homo sapiens) (aka runx family transcription factor 2)
B: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
C: cbf1 (homo sapiens) (aka recombination signal binding protein for immunoglobulin kappa j region)
D: ev... | [H; F] |
<Instruct>: Given the context 'In cells with t(3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aml1; evi1]
<Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: ev1 (homo sapiens) (aka transmembrane channel like 6)
C: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
D: aml2 (homo sapiens) (aka runx family transcription factor 3)
E: aml3 (homo sapiens) (aka runx family transcription... | [G; C] |
<Instruct>: Given the context 'In cells with t(3;21), additional fusion transcripts are AML1-MDS1 and AML1-MDS1-EVI1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [aml1; evi1]
<Options>: A: aml1t1 (homo sapiens) (aka runx1 partner transcriptional co-repressor 1)
B: af1 (homo sapiens) (aka ephrin a5)
C: aml-1 (xenopus tropicalis) (aka runx family transcription factor 1)
D: evin1 (homo sapiens) (aka transmembrane channel like 6)
E: evi3 (homo sapiens) (aka zinc finger ... | [G; I] |
<Instruct>: Given the context 'MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [evi1]
<Options>: A: ev1 (homo sapiens) (aka transmembrane channel like 6)
B: evi (homo sapiens) (aka wnt ligand secretion mediator)
C: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
D: evi-1 (homo sapiens) (aka runx family transcription factor 1)
E: eve-1 (homo sapiens) (aka sh3 domain containing 19... | [C] |
<Instruct>: Given the context 'MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [evi1]
<Options>: A: ev1 (homo sapiens) (aka transmembrane channel like 6)
B: eve-1 (homo sapiens) (aka sh3 domain containing 19)
C: evi-1 (homo sapiens) (aka runx family transcription factor 1)
D: evi (homo sapiens) (aka wnt ligand secretion mediator)
E: None of the above. | [E] |
<Instruct>: Given the context 'MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1 We have analyzed the relationship between MDS1 and EVI1 to determine whether they are two separate genes.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [evi1]
<Options>: A: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
B: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
C: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
D: evi3 (homo sapiens) (aka zinc finger protein 5... | [A] |
<Instruct>: Given the context 'In this report, we present evidence indicating that MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame.', select the correct biomedical concep... | <Mentions>: [evi1]
<Options>: A: eve-1 (homo sapiens) (aka sh3 domain containing 19)
B: evi-1 (homo sapiens) (aka runx family transcription factor 1)
C: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
D: evi (homo sapiens) (aka wnt ligand secretion mediator)
E: evi1 (homo sapiens) (aka mds1 and evi1 comple... | [E] |
<Instruct>: Given the context 'This additional region has about 40% homology at the amino acid level with the PR domain of the retinoblastoma-interacting zinc-finger protein RIZ.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [retinoblastoma-interacting zinc-finger protein riz]
<Options>: A: rb associated krab zinc finger (homo sapiens) (aka rb associated krab zinc finger)
B: riz2 (homo sapiens) (aka pr/set domain 2)
C: riaz (homo sapiens) (aka poz/btb and at hook containing zinc finger 1)
D: cdkn1a interacting zinc finger prote... | [B] |
<Instruct>: Given the context 'These results are important in view of the fact that EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [evi1]
<Options>: A: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: ev1 (homo sapiens) (aka transmembrane channel like 6)
D: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex... | [A] |
<Instruct>: Given the context 'MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mdc9]
<Options>: A: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
B: mda-9 (homo sapiens) (aka syndecan binding protein)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans... | [D] |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [mdc9; metalloprotease/disintegrin/cysteine-rich protein 9]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 9 (xenopus tropicalis) (aka disintegrin and metalloproteinase domain-containing protein 9)
B: mda-9 (homo sapiens) (aka syndecan binding protein)
C: adamts9 (homo sapiens) (a... | [I; I] |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [mdc9; metalloprotease/disintegrin/cysteine-rich protein 9]
<Options>: A: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
B: disintegrin and metalloproteinase domain-containing protein 9 (xenopus tropicalis) (aka disinteg... | [D; D] |
<Instruct>: Given the context 'MDC9 contains several distinct protein domains: a signal sequence is followed by a prodomain and a domain with sequence similarity to snake venom metalloproteases, a disintegrin domain, a cysteine-rich region, an EGF repeat, a membrane anchor, and a cytoplasmic tail.', select the correct ... | <Mentions>: [mdc9]
<Options>: A: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
B: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis ... | [E] |
<Instruct>: Given the context 'MDC9 contains several distinct protein domains: a signal sequence is followed by a prodomain and a domain with sequence similarity to snake venom metalloproteases, a disintegrin domain, a cysteine-rich region, an EGF repeat, a membrane anchor, and a cytoplasmic tail.', select the correct ... | <Mentions>: [mdc9]
<Options>: A: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
D: disintegrin and metallopr... | [E] |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [mdc9; src]
<Options>: A: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
B: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
C: adam9 (homo sapiens) (aka adam metallopeptid... | [C; H] |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [mdc9; src]
<Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: c-src2 (homo sapiens) (aka fgr proto-oncogene, src family tyrosine kinase)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
E: disintegrin and metalloprot... | [H; F] |
<Instruct>: Given the context 'Western blot analysis shows that MDC9 is an approximately 84-kD glycoprotein in all mouse tissues examined, and in NIH 3T3 fibroblast and C2C12 myoblast mouse cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mdc9]
<Options>: A: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
D: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: mdc9 (mus musculus) (aka adam metallopept... | [D] |
<Instruct>: Given the context 'MDC9 can be both cell surface biotinylated and 125I-labeled in NIH 3T3 mouse fibroblasts, indicating that the protein is present on the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [mdc9]
<Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: mda-9 (homo sapiens) (aka syndecan binding protein)
D: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
E: mdc-l (homo sapiens) (aka adam metallopeptidase d... | [A] |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [mdc9]
<Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-cont... | [B] |
<Instruct>: Given the context 'The apparent molecular mass of 84 kD suggests that MDC9 contains a membrane-anchored metalloprotease and disintegrin domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [mdc9]
<Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
C: mda-9 (homo sapiens) (aka syndecan binding protei... | [E] |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [mdc9]
<Options>: A: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
B: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: dis... | [B] |
<Instruct>: Given the context 'A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glra1]
<Options>: A: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
B: glr (homo sapiens) (aka glycine receptor alpha 2)
C: glra1 (homo sapiens) (aka glycine receptor alpha 1)
D: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
E: glutamate receptor 1.1-like (glycine max) (aka gl... | [C] |
<Instruct>: Given the context 'A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glra1]
<Options>: A: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glr (homo sapiens) (aka glycine receptor alpha 2)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
E: None of the above. | [E] |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [glycine receptor (glyr) alpha 1; glra1]
<Options>: A: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glr1.1 (arabidopsis thaliana) (aka glutamate receptor 1.1)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glyr1 (homo sapiens) (aka glyoxylate reduct... | [G; G] |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [glycine receptor (glyr) alpha 1; glra1]
<Options>: A: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glra2 (homo sapiens) (aka glycine receptor alpha 2)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
D: glycine rece... | [E; E] |
<Instruct>: Given the context 'In a recessive case of hyperekplexia, we found a deletion of exons 1-6 of the GLRA1 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glra1]
<Options>: A: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
B: glra1 (homo sapiens) (aka glycine receptor alpha 1)
C: glra2 (homo sapiens) (aka glycine receptor alpha 2)
D: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
E: glr1.1 (arabidopsis thaliana) (aka glu... | [B] |
<Instruct>: Given the context 'Born to consanguineous parents, the affected child is homozygous for this GLRA1(null) allele consistent with a complete loss of gene function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [glra1]
<Options>: A: glra1 (homo sapiens) (aka glycine receptor alpha 1)
B: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
C: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
D: glra2 (homo sapiens) (aka glycine receptor alpha 2)
E: glra1.l (xenopus laevis) (aka glycine recept... | [A] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
B: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
D... | [Q; Q; Q; Q] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: ot (drosophila melanogaster) (aka outheld)
B: otol1 (oryctolagus cuniculus) (aka otolin 1)
C: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
D: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
E: glyr-a1 (xenopus lae... | [S; S; S; S] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: glra1 (homo sapiens) (aka glycine receptor alpha 1)
B: otx1 (oryctolagus cuniculus) (aka orthodenticle homeobox 1)
C: otop1 (oryctolagus cuniculus) (aka otopetrin 1)
D: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
E: spdl1 (homo sapiens) (aka spindle... | [A; A; A; A] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
B: spdl1 (homo sapiens) (aka spindle apparatus coiled-coil protein 1)
C: ot (homo sapiens) (aka oxytocin/neurophysin i prepropeptide)
D: otr (homo sapiens) (aka oxytocin receptor)
E: spd1 (homo sapi... | [S; S; S; S] |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept for each mention using the provided optio... | <Mentions>: [glra1; spd; ot; glyr alpha 1]
<Options>: A: glr (homo sapiens) (aka glycine receptor alpha 2)
B: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
C: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: otx1 ... | [Q; Q; Q; Q] |
<Instruct>: Given the context 'Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand]
<Options>: A: apo3l (homo sapiens) (aka tnf superfamily member 12)
B: tall-2 (homo sapiens) (aka tnf superfamily member 13)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: apo-2l (homo sapiens) (aka tnf superfamily member 10)
E: cd40 ligand (homo sapiens) (aka cd40 ligand)
F: None of the a... | [D] |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand; apo-2l]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: trail (homo sapiens) (aka tnf superfamily member 10)
C: cd95-l (homo sapiens) (aka fas ligand)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: apo-l (homo sapiens) (aka apolipoprotein l1)
F: fas ligand (homo sapi... | [B; B] |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2 ligand; apo-2l]
<Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: cd95-l (homo sapiens) (aka fas ligand)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: tall-2 (homo sapiens) (aka tnf superfamily member 13)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: apo... | [H; H] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
B: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
C: apo2l (homo sapiens) (aka tnf superfamily member 10)
D: apol1 (homo sapiens) (aka apol... | [C; K; K] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: cd95l (homo sapiens) (aka fas ligand)
D: apol1 (homo sapiens) (aka apolipoprotein l1)
E: fast (homo sapiens) (fas activated ... | [J; N; N] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: cd95l (homo sapiens) (aka fas ligand)
D: cd40 ligand (homo sapiens) (aka cd40 ligand)
E: apol1 (homo sapiens) ... | [M; G; G] |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l; fas; apo-1 ligand]
<Options>: A: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
B: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
C: apo2l (homo sapiens) (aka tnf superfamily member 10)
D: t... | [C; B; B] |
<Instruct>: Given the context 'Transfected Apo-2L is expressed at the cell surface with its C terminus exposed, indicating a type II transmembrane protein topology.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [apo-2l]
<Options>: A: apo3l (homo sapiens) (aka tnf superfamily member 12)
B: apo2l (homo sapiens) (aka tnf superfamily member 10)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
E: tall2 (homo sapiens) (aka tnf superfamily member 13)
F: None... | [B] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: cd40 ligand (homo sapiens) (aka cd40 ligand)
C: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
D: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1... | [C; C; H] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apol1 (homo sapiens) (aka apolipoprotein l1)
B: cd95-l (homo sapiens) (aka fas ligand)
C: fasn (homo sapiens) (aka fatty acid synthase)
D: fas-as (homo sapiens) (aka fas antisense rna 1)
E: fas (gallus gallus) (aka fas cell surface death receptor)
F: tall-1 (homo sa... | [N; N; K] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
B: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
C: cd40 ligand (homo sapiens) (aka cd40 ligand)
D: tall-2 (homo sapiens) (... | [B; B; H] |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: cd95-l (homo sapiens) (aka fas ligand)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: fas ligand (homo sapiens) (aka fas ligand)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: fas (gallus gallus) (aka fas cell surface death receptor)
F: fa... | [J; J; I] |
<Instruct>: Given the context 'Soluble Apo-2L induces extensive apoptosis in lymphoid as well as non-lymphoid tumor cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [apo-2l]
<Options>: A: tall-2 (homo sapiens) (aka tnf superfamily member 13)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: cd95-l (homo sapiens) (aka fas ligand)
E: apol2 (homo sapiens) (aka apolipoprotein l2)
F: None of the above... | [C] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apol2 (homo sapiens) (aka apolipoprotein l2)
E: apo1 (homo sapiens) (aka apolipoprot... | [H; M; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: fas-as (homo sapiens) (aka fas antisens... | [O; N; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: cd95l (homo sapiens) (aka fas ligand)
C: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
D: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
E: fas-as (homo sapiens) (aka fas a... | [J; G; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: trail (homo sapiens) (aka tnf superfamily member 10)
B: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apof (homo sapiens) (aka apolipoprotein f)
E: apo2 (homo sapiens) (aka tnf ... | [A; I; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: fasn (homo sapiens) (aka fatty acid synthase)
C: tall2 (homo sapiens) (aka tnf superfamily member 13)
D: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/t... | [P; A; E] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
D: cd95-l (homo sapiens) (aka fas ligand)
E: cd951... | [P; C; N] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-1; fas; apo-2l]
<Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
E: fasps ... | [O; K; H] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apof (homo sapiens) (aka apolipoprotein f)
C: tall-2 (homo sapiens) (aka tnf superfamily member 13)
D: fasps (homo sapiens) (aka period circadian regulator 2)
E: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
F... | [M; O; P] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
B: fas (gallus gallus) (aka fas cell surface death receptor)
C: fasas (homo sapiens) (aka fas antisense rna 1)
D: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas ... | [M; D; O] |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts v... | <Mentions>: [apo-2l; fas; apo-1]
<Options>: A: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
B: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo-2l ... | [D; B; P] |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [fas; apo-1 ligand; apo-2l]
<Options>: A: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
B: trail (homo sapiens) (aka tnf superfamily member 10)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E:... | [L; L; B] |
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