instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)... | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: ergic-53l (mus musculus) (aka complexin 3)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
D: vip32 (homo sapiens) (aka arginine vasopressin induced 1)
E: ro60 (homo sapiens) (aka ro60, y... | [B; B; J] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)... | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: ro60 (homo sapiens) (aka ro60, y rna binding protein)
B: vip36-like (mus musculus) (aka lectin, mannose-binding 2-like)
C: vip36 (mus musculus) (aka lectin, mannose-binding 2)
D: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
E: ergic53 (drosop... | [N; N; L] |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [mr60; ergic-53]
<Options>: A: mr60 (homo sapiens) (aka lectin, mannose binding 1)
B: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
C: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
D: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
E: e... | [A; A] |
<Instruct>: Given the context 'We extend these findings in evidencing a structural homology between MR60/ERGIC-53 and mammalian galectins (soluble beta galactose binding proteins).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [mr60; ergic-53]
<Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
C: ergic-53l (mus musculus) (aka complexin 3)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 like)
E: ct60 (... | [F; F] |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: ro60 (homo sapiens) (aka ro60, y rna binding protein)
B: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
C: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
D: mr60 (homo sapiens) (aka lectin, mannose binding 1)
E: rad60 (homo sapiens) (aka ... | [D; D] |
<Instruct>: Given the context 'MR60/ERGIC-53 is the first lectin characterized as an endoplasmic reticulum-Golgi protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mr60; ergic-53]
<Options>: A: mr60 (homo sapiens) (aka lectin, mannose binding 1)
B: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
C: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
D: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
E: ct60 (homo sapi... | [A; A] |
<Instruct>: Given the context 'Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [type 1 tumor necrosis factor receptor]
<Options>: A: tnfrsf1a (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: dcr1-tnfr (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnfcr (homo sapiens) (aka lymphotoxin beta receptor... | [A] |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [type 1 receptor for tumor necrosis factor; tnfr-1ic]
<Options>: A: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
B: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
C: tnf-r-ii (homo sapiens) (aka tnf receptor superfamily member 1b)
D: tnfr-1 (r... | [A; A] |
<Instruct>: Given the context 'The yeast-based two hybrid has been used to identify a novel protein that binds to the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [type 1 receptor for tumor necrosis factor; tnfr-1ic]
<Options>: A: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
B: tnfr-1 (rattus norvegicus) (aka tnf receptor superfamily member 1a)
C: tnfr3 (homo sapiens) (aka lymphotoxin beta receptor)
D: tnfbr (homo sapie... | [E; E] |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [tnf receptor-associated protein; trap-1]
<Options>: A: tnf receptor-associated protein 1 (xenopus tropicalis) (aka tnf receptor-associated protein 1)
B: tnf receptor associated factor (traf) homolog (caenorhabditis elegans) (aka tnf receptor associated factor (traf) homolog)
C: trapa (homo sapiens) (aka si... | [K; K] |
<Instruct>: Given the context 'The TNF receptor-associated protein, TRAP-1, shows strong homology to members of the 90-kDa family of heat shock proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [tnf receptor-associated protein; trap-1]
<Options>: A: trap100 (homo sapiens) (aka mediator complex subunit 24)
B: trap1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: trap-1 (homo sapiens)... | [K; K] |
<Instruct>: Given the context 'After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [trap-1; tnfr-1ic]
<Options>: A: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
B: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
C: trap1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
D: trap-1 (bos tau... | [J; A] |
<Instruct>: Given the context 'After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [trap-1; tnfr-1ic]
<Options>: A: trap100 (homo sapiens) (aka mediator complex subunit 24)
B: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
C: trap95 (homo sapiens) (aka mediator complex subunit 16)
D: trap-1 (homo sapiens) (transforming grow... | [J; H] |
<Instruct>: Given the context 'The ability of deletion mutants of TNFR-1 to interact with TRAP-1 was tested using the two hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnfr-1; trap-1]
<Options>: A: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
B: trap95 (homo sapiens) (aka mediator complex subunit 16)
C: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
D: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
E: trap1 (hom... | [H; I] |
<Instruct>: Given the context 'The ability of deletion mutants of TNFR-1 to interact with TRAP-1 was tested using the two hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tnfr-1; trap-1]
<Options>: A: tnf receptor superfamily member 1b (homo sapiens) (aka tnf receptor superfamily member 1b)
B: trap1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: tnfr-rp (hom... | [F; I] |
<Instruct>: Given the context 'This showed that the amino acid sequences that mediate binding are diffusely distributed outside of the domain in the C terminus of TNFR-1IC that signals cytotoxicity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [tnfr-1ic]
<Options>: A: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnf receptor superfamily member 10c (homo sapiens) (aka tnf receptor superfamily member 10c)
D: tnf-r-i (homo sapiens) (aka tnf receptor superfamily member 1a)
E:... | [D] |
<Instruct>: Given the context 'The 2.4-kilobase TRAP-1 mRNA was variably expressed in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, and placenta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [trap-1]
<Options>: A: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
B: trap150 (homo sapiens) (aka thyroid hormone receptor associated protein 3)
C: trap1 (homo sapiens) (tnf receptor ... | [F] |
<Instruct>: Given the context 'TRAP-1 mRNA was also detected in each of eight different transformed cell lines.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trap-1]
<Options>: A: trap-1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
B: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
C: trap95 (homo sapiens) (aka mediator complex subunit 16)
D: trap100 (homo sapiens) (aka mediator complex ... | [F] |
<Instruct>: Given the context 'Identification of TRAP-1 may be an important step toward defining how TNFR-1, which does not contain protein tyrosine kinase activity, transmits its message to signal transduction pathways.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [trap-1; tnfr-1]
<Options>: A: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
B: trap-1 (homo sapiens) (transforming growth factor beta receptor associated protein 1 (homo sapiens)) (aka transforming growth factor beta receptor associated protein 1)
C: tnfcr (homo sa... | [I; D] |
<Instruct>: Given the context 'Identification of TRAP-1 may be an important step toward defining how TNFR-1, which does not contain protein tyrosine kinase activity, transmits its message to signal transduction pathways.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [trap-1; tnfr-1]
<Options>: A: trap-1 (bos taurus) (aka transforming growth factor beta receptor associated protein 1)
B: tnfbr (homo sapiens) (aka tnf receptor superfamily member 1b)
C: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
D: trap150 (homo sapiens) (aka thyroid hormone receptor associated p... | [H; H] |
<Instruct>: Given the context 'Identification of TRAP-1 may be an important step toward defining how TNFR-1, which does not contain protein tyrosine kinase activity, transmits its message to signal transduction pathways.', select the correct biomedical concept for each mention using the provided options. Answer by list... | <Mentions>: [trap-1; tnfr-1]
<Options>: A: trap1 (homo sapiens) (tnf receptor associated protein 1 (homo sapiens)) (aka tnf receptor associated protein 1)
B: tnfcr (homo sapiens) (aka lymphotoxin beta receptor)
C: trapa (homo sapiens) (aka signal sequence receptor subunit 1)
D: trap100 (homo sapiens) (aka mediator comp... | [I; E] |
<Instruct>: Given the context 'Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stomach alcohol dehydrogenase]
<Options>: A: adh7 (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: adh1a (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
C: alcohol dehydrogenase 6 (class v) (homo sapiens) (aka alcohol dehydrogenase 6 (class v))
... | [A] |
<Instruct>: Given the context 'A full-length 1966-base pair clone of the human class IV alcohol dehydrogenase (sigma-ADH) was isolated from a human stomach cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [class iv alcohol dehydrogenase; sigma-adh]
<Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase adh4 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh4)
C: alcohol de... | [A; A] |
<Instruct>: Given the context 'A full-length 1966-base pair clone of the human class IV alcohol dehydrogenase (sigma-ADH) was isolated from a human stomach cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [class iv alcohol dehydrogenase; sigma-adh]
<Options>: A: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
B: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma poly... | [B; B] |
<Instruct>: Given the context 'The 373-amino acid sigma-ADH encoded by this cDNA was expressed in Escherichia coli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sigma-adh]
<Options>: A: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), ... | [A] |
<Instruct>: Given the context 'Kinetic analysis of the catalytic efficiency (kcat/KM) of recombinant sigma-ADH for oxidation of primary alcohols indicated broad substrate specificity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh2)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenase adh1 (saccharomyces ... | [B] |
<Instruct>: Given the context 'Recombinant human sigma-ADH exhibited high catalytic efficiency for oxidation of all-trans-retinol to all-trans-retinal.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [sigma-adh]
<Options>: A: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
C: alcohol dehydrogenas... | [A] |
<Instruct>: Given the context 'Recombinant human sigma-ADH exhibited high catalytic efficiency for oxidation of all-trans-retinol to all-trans-retinal.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (rattus norvegicus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenase adh1 (saccharom... | [E] |
<Instruct>: Given the context 'Secondary alcohols and 3 beta-hydroxysteroids were inactive with sigma-ADH or were oxidized with very low efficiency.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase adh5 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh5)
B: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
C: alcohol dehydrogenase adh2 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh... | [E] |
<Instruct>: Given the context 'The KM of sigma-ADH for ethanol was 25 mM, and the KM for primary straight chain alcohols decreased substantially as chain length increased.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, s... | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
B: alcohol dehydrogenase 1a (class i), alpha polypeptide (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
C: alcoho... | [E] |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency... | <Mentions>: [class iv (sigma); class i (beta) alcohol dehydrogenases; sigma-adh; beta 1-adh]
<Options>: A: adh1b (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
B: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens) (aka alcohol dehydrogenase 7 (class iv), mu or sigma po... | [L; A; L; A] |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency... | <Mentions>: [class iv (sigma); class i (beta) alcohol dehydrogenases; sigma-adh; beta 1-adh]
<Options>: A: sigma1b (homo sapiens) (aka adaptor related protein complex 1 subunit sigma 2)
B: adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
C: adh1 (homo sapiens) (aka alcohol dehydrogenase 1a (class ... | [J; E; J; E] |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency... | <Mentions>: [class iv (sigma); class i (beta) alcohol dehydrogenases; sigma-adh; beta 1-adh]
<Options>: A: alcohol dehydrogenase 1b (class i), beta polypeptide (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
B: adh1 (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
C: ... | [Q; A; Q; A] |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency... | <Mentions>: [class iv (sigma); class i (beta) alcohol dehydrogenases; sigma-adh; beta 1-adh]
<Options>: A: sigma1r (homo sapiens) (aka sigma non-opioid intracellular receptor 1)
B: adh1 (homo sapiens) (aka alcohol dehydrogenase 1a (class i), alpha polypeptide)
C: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv),... | [C; K; C; K] |
<Instruct>: Given the context 'There are important amino acid differences in the alcohol-binding site between the human class IV (sigma) and human class I (beta) alcohol dehydrogenases that appear to explain the high catalytic efficiency for all-trans-retinol, the high kcat for ethanol, and the low catalytic efficiency... | <Mentions>: [class iv (sigma); class i (beta) alcohol dehydrogenases; sigma-adh; beta 1-adh]
<Options>: A: sigma1b (homo sapiens) (aka adaptor related protein complex 1 subunit sigma 2)
B: adh1c (homo sapiens) (aka alcohol dehydrogenase 1c (class i), gamma polypeptide)
C: sigma3b (homo sapiens) (aka adaptor related pro... | [N; P; N; P] |
<Instruct>: Given the context 'For example, modeling the binding of all-trans-retinol in the human beta 1-ADH structure suggested that coordination of retinol to the active-site zinc is hindered by a loop from residues 114 to 120 that is at the entrance to the alcohol-binding site.', select the correct biomedical conce... | <Mentions>: [beta 1-adh]
<Options>: A: alcohol dehydrogenase 1b (class i), beta polypeptide (homo sapiens) (aka alcohol dehydrogenase 1b (class i), beta polypeptide)
B: adh1c (homo sapiens) (aka alcohol dehydrogenase 1c (class i), gamma polypeptide)
C: adh1b promoter (homo sapiens) (aka adh1b promoter)
D: adh1b (bos ta... | [A] |
<Instruct>: Given the context 'The deletion of Gly-117 in human sigma-ADH and a substitution of Leu for the bulky Tyr-110 appear to facilitate retinol access to the active-site zinc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
B: adh4 (homo sapiens) (alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (homo sapiens)) (aka alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide)
C: alcohol dehydrogenas... | [B] |
<Instruct>: Given the context 'The deletion of Gly-117 in human sigma-ADH and a substitution of Leu for the bulky Tyr-110 appear to facilitate retinol access to the active-site zinc.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each... | <Mentions>: [sigma-adh]
<Options>: A: alcohol dehydrogenase adh1 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh1)
B: alcohol dehydrogenase adh3 (saccharomyces cerevisiae s288c) (aka alcohol dehydrogenase adh3)
C: alcohol dehydrogenase 7 (class iv), mu or sigma polypeptide (mus musculus) (aka alcohol de... | [E] |
<Instruct>: Given the context 'The first 240 nucleotides in the 5' untranslated region of type I acetyl-CoA-carboxylase mRNA replace the first 100 nucleotides of the (G + C)-rich region of the 5' untranslated region of the type II mRNA.', select the correct biomedical concept for each mention using the provided options... | <Mentions>: [type i acetyl-coa-carboxylase]
<Options>: A: acetyl-coa carboxylase 1 (arabidopsis thaliana) (aka acetyl-coa carboxylase 1)
B: acc1 (homo sapiens) (acetyl-coa carboxylase alpha (homo sapiens)) (aka acetyl-coa carboxylase alpha)
C: propionyl-coa carboxylase subunit alpha (homo sapiens) (aka propionyl-coa ca... | [B] |
<Instruct>: Given the context 'Human mu opiate receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mu opiate receptor]
<Options>: A: opr (mus musculus) (aka zinc finger protein of the cerebellum 5)
B: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: nop (mus musculus) (opioid receptor-like 1 (mus musculus)) (aka opioid receptor-like 1)
D: opioid rece... | [D] |
<Instruct>: Given the context 'A human mu opiate receptor cDNA has been identified from a cerebral cortical cDNA library using sequences from the rat mu opiate receptor cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [mu opiate receptor]
<Options>: A: opr (mus musculus) (aka zinc finger protein of the cerebellum 5)
B: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
C: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
D: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid re... | [C] |
<Instruct>: Given the context 'The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mu opiate receptor; h mu or1]
<Options>: A: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: opioid receptor, mu 1 (rattus norvegicus) (aka opioid receptor, mu 1)
C: m-or-1 (mus musculus) (aka opioid receptor, mu 1)
D: or-1 (mus musculus) (aka nuclear recept... | [I; I] |
<Instruct>: Given the context 'The human mu opiate receptor (h mu OR1) shares 95% amino acid identity with the rat sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mu opiate receptor; h mu or1]
<Options>: A: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
B: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: opioid receptor mu 1 (homo sapiens) (aka opioid receptor mu 1)
D: opioid related nociceptin recep... | [C; C] |
<Instruct>: Given the context 'The expressed mu OR1 recognized tested opiate drugs and opioid peptides in a sodium- and GTP-sensitive fashion with affinities virtually identical to those displayed by the rat mu opiate receptor.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [mu or1; mu opiate receptor]
<Options>: A: or1o1 (mus musculus) (aka olfactory receptor family 1 subfamily o member 1)
B: or-1 (mus musculus) (aka nuclear receptor subfamily 1, group h, member 2)
C: opioid receptor, mu 1 (rattus norvegicus) (aka opioid receptor, mu 1)
D: opr (mus musculus) (aka zinc finger ... | [K; H] |
<Instruct>: Given the context 'The expressed mu OR1 recognized tested opiate drugs and opioid peptides in a sodium- and GTP-sensitive fashion with affinities virtually identical to those displayed by the rat mu opiate receptor.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [mu or1; mu opiate receptor]
<Options>: A: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
B: opioid growth factor receptor (mus musculus) (aka opioid growth factor receptor)
C: or1o1 (mus musculus) (aka olfactory receptor family 1 subfamily o member 1)
D: or1af1 (mus musculus) (aka olfacto... | [K; H] |
<Instruct>: Given the context 'Effects on cyclic AMP are similar to those noted for the rat mu opiate receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mu opiate receptor]
<Options>: A: opioid related nociceptin receptor 1 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: opioid related nociceptin receptor 1 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: opioid receptor, mu 1 (mus musculus) (aka opioid receptor, mu 1)
D: opr ... | [A] |
<Instruct>: Given the context 'An 18 kb genomic clone hybridizing with the h mu OR1 cDNA contains 63 and 489 bp exonic sequences flanked by splice donor/acceptor sequences.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [h mu or1]
<Options>: A: or1o1 (mus musculus) (aka olfactory receptor family 1 subfamily o member 1)
B: or1n1 (mus musculus) (aka olfactory receptor family 1 subfamily n member 1)
C: m-or-1 (homo sapiens) (aka opioid receptor mu 1)
D: or-1 (mus musculus) (aka nuclear receptor subfamily 1, group h, member 2)... | [C] |
<Instruct>: Given the context 'Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options... | <Mentions>: [cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a synthase]
<Options>: A: 3-hydroxy-3-methylglutaryl-coa reductase (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa reductase)
B: 3-hydroxy-3-methylglutaryl-coa synthase 1 (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa synthase 1)
C: 3-hydroxy-3-methylg... | [B] |
<Instruct>: Given the context 'A cDNA for the human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase (EC 4.1.3.5) was subcloned and expressed from a T7-based vector in Escherichia coli.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) synthase]
<Options>: A: 3-hydroxy-3-methylglutaryl-coa synthase 2 (homo sapiens) (aka 3-hydroxy-3-methylglutaryl-coa synthase 2)
B: 3-hydroxy-3-methylglutaryl-coenzyme a synthase 1 (soluble) pseudogene (homo sapiens) (aka 3-hydroxy-3-methylglutary... | [C] |
<Instruct>: Given the context 'Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta subunit of the high-affinity immunoglobulin e receptor]
<Options>: A: endothelin receptor type b (homo sapiens) (aka endothelin receptor type b)
B: cd99b (homo sapiens) (aka cd99 molecule like 2)
C: estrogen related receptor beta (bos taurus) (aka estrogen related receptor beta)
D: cd79b molecule (hom... | [F] |
<Instruct>: Given the context 'The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [beta-subunit of the high-affinity ige receptor; fc epsilon ri-beta]
<Options>: A: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
B: cd79b (homo sapiens) (aka cd79b molecule)
C: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
D: cd179b (homo sapiens) (aka immunoglobulin lambda lik... | [K; K] |
<Instruct>: Given the context 'The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis.', select the correct biomedical concept for each mention using the provided options. An... | <Mentions>: [beta-subunit of the high-affinity ige receptor; fc epsilon ri-beta]
<Options>: A: fcgammariia (homo sapiens) (aka fc gamma receptor iia)
B: cd99b (homo sapiens) (aka cd99 molecule like 2)
C: cd179b (homo sapiens) (aka immunoglobulin lambda like polypeptide 1)
D: cd64b (homo sapiens) (aka fc gamma receptor ... | [K; K] |
<Instruct>: Given the context 'We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fc epsilon ri-beta]
<Options>: A: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
B: fcgr1b (homo sapiens) (aka fc gamma receptor ib, pseudogene)
C: fcriiib (homo sapiens) (aka fc gamma receptor iiib)
D: fc gamma receptor iib (homo sapiens) (aka fc gamma receptor iib)
E: fcgammariic (hom... | [F] |
<Instruct>: Given the context 'Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by se... | <Mentions>: [fc epsilon ri-beta]
<Options>: A: fcgammariic (homo sapiens) (aka fc gamma receptor iic (gene/pseudogene))
B: cd64b (homo sapiens) (aka fc gamma receptor ib, pseudogene)
C: fc epsilon receptor ii (homo sapiens) (aka fc epsilon receptor ii)
D: cd16b (homo sapiens) (aka fc gamma receptor iiib)
E: fcgammariia... | [F] |
<Instruct>: Given the context 'Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thyrotropin receptor]
<Options>: A: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: thyroid stimulating hormone receptor (rattus norvegicus) (aka thyroid stimulating hormone receptor)
C: thyrotropin releasing hormone receptor (rattus norvegicus) (aka th... | [E] |
<Instruct>: Given the context 'The thyrotropin receptor (TSHR), a member of the large family of G protein-coupled receptors, controls both the function and growth of thyroid cells via stimulation of adenylyl cyclase.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [thyrotropin receptor; tshr]
<Options>: A: thyrotropin releasing hormone receptor (bos taurus) (aka thyrotropin releasing hormone receptor)
B: tshr (bos taurus) (aka thyroid stimulating hormone receptor)
C: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
D: thyroid stimulating hormone r... | [D; D] |
<Instruct>: Given the context 'The thyrotropin receptor (TSHR), a member of the large family of G protein-coupled receptors, controls both the function and growth of thyroid cells via stimulation of adenylyl cyclase.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [thyrotropin receptor; tshr]
<Options>: A: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
B: tshr (bos taurus) (aka thyroid stimulating hormone receptor)
C: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
D: tshr (homo sapiens) (aka thyr... | [D; D] |
<Instruct>: Given the context 'We report two different mutations in the TSHR gene of affected members of two large pedigrees with non-autoimmune autosomal dominant hyperthyroidism (toxic thyroid hyperplasia), that involve residues in the third (Val509Ala) and seventh (Cys672Tyr) transmembrane segments.', select the cor... | <Mentions>: [tshr]
<Options>: A: thyrotropin releasing hormone receptor (homo sapiens) (aka thyrotropin releasing hormone receptor)
B: thyrotropin-releasing hormone receptor (bos taurus) (aka thyrotropin-releasing hormone receptor)
C: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
D: tshr (rattus ... | [E] |
<Instruct>: Given the context 'X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: l1 (drosophila melanogaster) (retroactive (drosophila melanogaster)) (aka retroactive)
B: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
... | [D] |
<Instruct>: Given the context 'We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [neural cell adhesion molecule l1; l1cam]
<Options>: A: neural cell adhesion molecule 1 (homo sapiens) (aka neural cell adhesion molecule 1)
B: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
C: l1cam (mus musculus) (aka l1 cell adhesion molecule)
D: l1cam (gallus gallus) ... | [E; E] |
<Instruct>: Given the context 'We have previously shown that X-linked hydrocephalus is caused by mutations in the gene for neural cell adhesion molecule L1 (L1CAM), an axonal glycoprotein involved in neuronal migration and differentiation.', select the correct biomedical concept for each mention using the provided opti... | <Mentions>: [neural cell adhesion molecule l1; l1cam]
<Options>: A: neural cell adhesion molecule 1 (homo sapiens) (aka neural cell adhesion molecule 1)
B: l1cam (mus musculus) (aka l1 cell adhesion molecule)
C: cell adhesion molecule l1 like (homo sapiens) (aka cell adhesion molecule l1 like)
D: l1cam (gallus gallus) ... | [G; G] |
<Instruct>: Given the context 'Here we report mutations of the L1 gene in MASA syndrome and SPG1, in addition to HSAS families.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l1]
<Options>: A: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
B: cyclin l1 (homo sapiens) (aka cyclin l1)
C: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
D: l1.1 (mus musculus) (aka skull morphology 1)
E: l1 (drosophila melanogaster) ... | [C] |
<Instruct>: Given the context 'Two of the HSAS mutations would abolish cell surface expression of L1 and represent the first functional null mutations in this disorder.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [l1]
<Options>: A: l(1)l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster)) (aka lethal (1) l1)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: l1 cell adhesion molecule (xenopus tropicalis) (aka l1 cell adhesion mo... | [B] |
<Instruct>: Given the context 'Our results indicate that these three syndromes from part of a clinical spectrum resulting from a heterogeneous group of mutations in the L1 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [l1]
<Options>: A: l1.1 (mus musculus) (aka skull morphology 1)
B: l1 cell adhesion molecule (homo sapiens) (aka l1 cell adhesion molecule)
C: cyclin l1 (homo sapiens) (aka cyclin l1)
D: cell adhesion molecule l1-like (xenopus tropicalis) (aka cell adhesion molecule l1-like)
E: adhesion g protein-coupled re... | [B] |
<Instruct>: Given the context 'Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta.
Bradykinin exerts a broad spectrum of cellular effects on different tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [bradykinin]
<Options>: A: bradykinin (xenopus tropicalis) (aka bradykinin receptor b2)
B: kininogen 1 (bos taurus) (aka kininogen 1)
C: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
D: bk (homo sapiens) (aka kininogen 1)
E: kallikrein (homo sapiens) (aka kallikrein related peptidase 4)... | [D] |
<Instruct>: Given the context 'It is believed that these effects are predominantly mediated by the recently cloned B2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b2 receptor]
<Options>: A: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
B: bkr2 (homo sapiens) (aka bradykinin receptor b2)
C: bkb1r (homo sapiens) (aka bradykinin receptor b1)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
F: N... | [B] |
<Instruct>: Given the context 'Involvement of protein kinase C (PKC) was suggested and activation of the classical PKC isoforms alpha and beta was recently demonstrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [pkc isoforms alpha]
<Options>: A: protein kinase camp-activated catalytic subunit alpha (homo sapiens) (aka protein kinase camp-activated catalytic subunit alpha)
B: protein kinase c, alpha (xenopus tropicalis) (aka protein kinase c, alpha)
C: protein kinase c iota (homo sapiens) (aka protein kinase c iota... | [E] |
<Instruct>: Given the context 'The aim of the present study was to investigate whether the B2 receptor also activates new (delta, epsilon) and atypical (zeta) PKC isoforms.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [b2 receptor]
<Options>: A: b2r (homo sapiens) (aka bradykinin receptor b2)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
F: No... | [A] |
<Instruct>: Given the context 'The aim of the present study was to investigate whether the B2 receptor also activates new (delta, epsilon) and atypical (zeta) PKC isoforms.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [b2 receptor]
<Options>: A: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
B: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
C: bkb1r (homo sapiens) (aka bradykinin receptor b1)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: None of the above. | [E] |
<Instruct>: Given the context 'To investigate this, chinese hamster ovary (CHO) cells, stably transfected with human B2 receptor, were used.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b2 receptor]
<Options>: A: bkb1r (homo sapiens) (aka bradykinin receptor b1)
B: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
C: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: b2ar (homo sapiens) (aka adrenoce... | [C] |
<Instruct>: Given the context 'Stimulation of the cells with bradykinin resulted in a rapid (30-60 s) translocation of the PKC isoforms alpha, epsilon, and zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [bradykinin]
<Options>: A: kallikrein b1 (homo sapiens) (aka kallikrein b1)
B: kallikrein b1 (bos taurus) (aka kallikrein b1)
C: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
D: bk (homo sapiens) (aka kininogen 1)
E: bradykinin receptor b1 (homo sapiens) (aka bradykinin receptor b1)
F: ... | [D] |
<Instruct>: Given the context 'Translocation of PKC delta was not detected.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pkc delta]
<Options>: A: protein kinase c delta (homo sapiens) (aka protein kinase c delta)
B: pkcdelta (drosophila melanogaster) (aka protein kinase c delta)
C: protein kinase c delta (xenopus tropicalis) (aka protein kinase c delta)
D: protein kinase c delta (bos taurus) (aka protein kinase c delta)
E: N... | [A] |
<Instruct>: Given the context 'The effect of bradykinin was reduced by simultaneous addition of the receptor antagonist HOE 140, a bradykinin-related decapeptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [bradykinin]
<Options>: A: kallikrein b1 (homo sapiens) (aka kallikrein b1)
B: kallikrein b1 (bos taurus) (aka kallikrein b1)
C: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
D: bk (homo sapiens) (aka kininogen 1)
E: bradykinin (xenopus laevis) (bradykinin receptor b2 s homeolog (xenopu... | [D] |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [b2 receptor; pkc isoform alpha; pkc isoform epsilon; pkc isoform zeta]
<Options>: A: protein kinase c, epsilon (mus musculus) (aka protein kinase c, epsilon)
B: prkaa (homo sapiens) (aka protein kinase amp-activated catalytic subunit alpha 2)
C: protein kinase c, alpha (xenopus tropicalis) (aka protein kin... | [K; T; O; G] |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [b2 receptor; pkc isoform alpha; pkc isoform epsilon; pkc isoform zeta]
<Options>: A: protein kinase c eta (homo sapiens) (aka protein kinase c eta)
B: protein kinase c, alpha (xenopus tropicalis) (aka protein kinase c, alpha)
C: b2ar (homo sapiens) (aka adrenoceptor beta 2)
D: blr2 (homo sapiens) (aka c-c ... | [L; H; S; G] |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [b2 receptor; pkc isoform alpha; pkc isoform epsilon; pkc isoform zeta]
<Options>: A: protein kinase c, zeta (rattus norvegicus) (aka protein kinase c, zeta)
B: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
C: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
D: protein kinase c, alpha (xenopus ... | [R; S; P; H] |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [b2 receptor; pkc isoform alpha; pkc isoform epsilon; pkc isoform zeta]
<Options>: A: protein kinase c epsilon (sus scrofa) (aka protein kinase c epsilon)
B: bkb1r (homo sapiens) (aka bradykinin receptor b1)
C: protein kinase c zeta (homo sapiens) (aka protein kinase c zeta)
D: protein kinase c, epsilon (mu... | [I; P; T; C] |
<Instruct>: Given the context 'The data show that the B2 receptor in this cell model is able to activate, in addition to the classical PKC isoform alpha, the new PKC isoform epsilon and the atypical PKC isoform zeta.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [b2 receptor; pkc isoform alpha; pkc isoform epsilon; pkc isoform zeta]
<Options>: A: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
B: protein kinase c, zeta (danio rerio) (aka protein kinase c, zeta)
C: protein kinase c, epsilon (mus musculus) (aka protein kinase c, epsilon)
D: protein kinase c ... | [G; T; Q; K] |
<Instruct>: Given the context 'In this cell system similar results on PKC alpha, epsilon, and zeta were observed, suggesting that all three PKC isoforms are involved in signal transduction of the B2 receptor.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sele... | <Mentions>: [b2 receptor]
<Options>: A: bkb1r (homo sapiens) (aka bradykinin receptor b1)
B: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
C: b2ar (homo sapiens) (aka adrenoceptor beta 2)
D: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
E: blr2 (homo sapiens) (aka c-c motif chemokine... | [D] |
<Instruct>: Given the context 'Protein structure of fetal antigen 1 (FA1).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fetal antigen 1; fa1]
<Options>: A: fa complementation group i (homo sapiens) (aka fa complementation group i)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: faf1 (homo sapiens) (aka fas associated factor 1)
D: feta (homo sapiens) (alpha fetoprotein (homo sapiens)) (aka alpha fetoprotei... | [J; J] |
<Instruct>: Given the context 'Protein structure of fetal antigen 1 (FA1).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fetal antigen 1; fa1]
<Options>: A: fam1a (homo sapiens) (aka metallophosphoesterase domain containing 1)
B: mage family member f1 (homo sapiens) (aka mage family member f1)
C: fa1 (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
D: fet1 (homo sapiens) (aka dopami... | [K; K] |
<Instruct>: Given the context 'A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [dlk; pg2]
<Options>: A: phosphoglycerate kinase 2 (homo sapiens) (aka phosphoglycerate kinase 2)
B: dlk-1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
C: pgap2 (homo sapiens) (aka post-gpi attachment to proteins 2)
D: dlk/zpk (drosophila melanogaster) (aka wallenda)
E: polygalacturonase pg2... | [B; B] |
<Instruct>: Given the context 'A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for eac... | <Mentions>: [dlk; pg2]
<Options>: A: dlk1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
B: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
C: dlk/zpk (drosophila melanogaster) (aka wallenda)
D: pgk2 (homo sapiens) (phosphoglycerate kinase 1, pseudogene 2 (homo sapiens)) (aka phosphoglyce... | [A; A] |
<Instruct>: Given the context 'The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [fetal antigen 1; fa1]
<Options>: A: fam1a (homo sapiens) (aka metallophosphoesterase domain containing 1)
B: faf1 (homo sapiens) (aka fas associated factor 1)
C: fet1 (homo sapiens) (aka dopamine receptor d3)
D: fat1 (homo sapiens) (aka fat atypical cadherin 1)
E: fa complementation group f (homo sapiens) ... | [J; J] |
<Instruct>: Given the context 'The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [fetal antigen 1; fa1]
<Options>: A: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
B: faf1 (homo sapiens) (aka fas associated factor 1)
C: fa complementation group i (homo sapiens) (aka fa complementation group i)
D: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
E: atrial fibrillation, f... | [J; J] |
<Instruct>: Given the context 'FA1 is a single-chained, heterogeneous glycoprotein of 225-262 amino acid residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fa1]
<Options>: A: fa1 (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
D: faf1 (homo sapiens) (aka f... | [F] |
<Instruct>: Given the context 'FA1 has six well conserved epidermal-growth-factor motifs and contains up to ten O-glycosylation and N-glycosylation sites, six of which are differentially glycosylated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [fa1]
<Options>: A: fa complementation group f (homo sapiens) (aka fa complementation group f)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
D: fah1 (homo sapiens) (aka fatty acid 2-hydroxyla... | [F] |
<Instruct>: Given the context 'Alignment to the translated sequences of Mus. musculus dlk and human dlk revealed 86% and 99% identity, respectively, to a 259-amino-acid residue overlap, and this high similarity extends with minor corrections to the human adrenal-specific mRNA, pG2 as well.', select the correct biomedic... | <Mentions>: [dlk; pg2]
<Options>: A: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
B: pgdp2 (homo sapiens) (aka phosphogluconate dehydrogenase pseudogene 2)
C: dlk-2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
D: pgap2 (homo sapiens) (aka post-gpi attachment to proteins 2)
E: pgm2 (h... | [H; H] |
<Instruct>: Given the context 'Alignment to the translated sequences of Mus. musculus dlk and human dlk revealed 86% and 99% identity, respectively, to a 259-amino-acid residue overlap, and this high similarity extends with minor corrections to the human adrenal-specific mRNA, pG2 as well.', select the correct biomedic... | <Mentions>: [dlk; pg2]
<Options>: A: dlg (drosophila melanogaster) (discs large 2 (drosophila melanogaster)) (aka discs large 2)
B: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
C: dlak (drosophila melanogaster) (aka i-kappab kinase beta)
D: pgk2 (homo sapiens) (phosphoglycerate kinase 1, pseudogene ... | [G; G] |
<Instruct>: Given the context 'Immunohistochemical analysis demonstrated the presence of FA1 in 10 out of 14 lung tumors containing neuroendocrine elements, and in the placental villi where FA1 was exclusively seen in stromal cells in close contact to the vascular structure.', select the correct biomedical concept for ... | <Mentions>: [fa1]
<Options>: A: fa complementation group i (homo sapiens) (aka fa complementation group i)
B: fa-1 (homo sapiens) (aka small nuclear ribonucleoprotein 13)
C: fa complementation group f (homo sapiens) (aka fa complementation group f)
D: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka ... | [F] |
<Instruct>: Given the context 'In the pancreas, FA1 co-localized with insulin in the insulin secretory granules of the beta cells within the islets of Langerhans.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [fa1]
<Options>: A: fah1 (homo sapiens) (aka fatty acid 2-hydroxylase)
B: fah (homo sapiens) (fa complementation group a (homo sapiens)) (aka fa complementation group a)
C: fa complementation group i (homo sapiens) (aka fa complementation group i)
D: fa complementation group f (homo sapiens) (aka fa complem... | [F] |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: dlk/zpk (drosophila melanogaster) (aka wallenda)
B: dlk2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
C: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
D: fa complementation group i (homo sapiens) (aka fa compleme... | [N; N; N] |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: dlk-1 (homo sapiens) (aka delta like non-canonical notch ligand 1)
B: dlk (drosophila melanogaster) (leucokinin (drosophila melanogaster)) (aka leucokinin)
C: dlk2 (homo sapiens) (aka delta like non-canonical notch ligand 2)
D: pgdp2 (homo sapiens) (aka phosphogluconate dehydro... | [A; A; A] |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: dlg (drosophila melanogaster) (discs large 2 (drosophila melanogaster)) (aka discs large 2)
B: pg2 (mus musculus) (aka delta like non-canonical notch ligand 1)
C: faf1 (homo sapiens) (aka fas associated factor 1)
D: dlak (drosophila melanogaster) (aka i-kappab kinase beta)
E: p... | [G; G; G] |
<Instruct>: Given the context 'Our findings suggest that FA1 is synthesized as a membrane anchored protein and released into the circulation after enzymic cleavage, and that circulating FA1 represents the post-translationally modified gene product of human dlk which, in turn, is identical to human adrenal-specific mRNA... | <Mentions>: [fa1; dlk; pg2]
<Options>: A: dlk (drosophila melanogaster) (leucokinin (drosophila melanogaster)) (aka leucokinin)
B: phosphoglycerate kinase 2 (homo sapiens) (aka phosphoglycerate kinase 2)
C: faf (homo sapiens) (fa complementation group f (homo sapiens)) (aka fa complementation group f)
D: polygalacturon... | [N; N; N] |
<Instruct>: Given the context 'Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna helicase ii]
<Options>: A: dna helicase b (homo sapiens) (aka dna helicase b)
B: dnase2 (homo sapiens) (aka deoxyribonuclease 2, lysosomal)
C: dnah2 (homo sapiens) (aka dynein axonemal heavy chain 2)
D: dna replication helicase/nuclease 2 (homo sapiens) (aka dna replication helicase/nuclease 2)
E: dbp2... | [F] |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select ... | <Mentions>: [dna helicase ii; hdh ii]
<Options>: A: dbp2 (homo sapiens) (aka deah-box helicase 16)
B: hyd2 (homo sapiens) (aka hypodontia 2 (autosomal recessive))
C: dna helicase ii (escherichia coli str. k-12 substr. mg1655) (aka dna helicase ii)
D: dna helicase b (homo sapiens) (aka dna helicase b)
E: phd2 (homo sapi... | [K; K] |
<Instruct>: Given the context 'Human DNA helicase II (HDH II) is a novel ATP-dependent DNA unwinding enzyme, purified to apparent homogeneity from HeLa cells, which (i) unwinds exclusively DNA duplexes, (ii) prefers partially unwound substrates and (iii) proceeds in the 3' to 5' direction on the bound strand.', select ... | <Mentions>: [dna helicase ii; hdh ii]
<Options>: A: dnase2 (homo sapiens) (aka deoxyribonuclease 2, lysosomal)
B: dna helicase b (homo sapiens) (aka dna helicase b)
C: dna replication helicase/nuclease 2 (homo sapiens) (aka dna replication helicase/nuclease 2)
D: cphd2 (homo sapiens) (aka prop paired-like homeobox 1)
E... | [K; K] |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdh ii; heterodimer of 72 and 87 kda polypeptides]
<Options>: A: p87/89 (homo sapiens) (aka inner membrane mitochondrial protein)
B: hnrnpa1p72 (homo sapiens) (aka heterogeneous nuclear ribonucleoprotein a1 pseudogene 72)
C: hst17287 (homo sapiens) (aka aquaporin 9)
D: signal recognition particle 72 (homo ... | [K; K] |
<Instruct>: Given the context 'HDH II is a heterodimer of 72 and 87 kDa polypeptides.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hdh ii; heterodimer of 72 and 87 kda polypeptides]
<Options>: A: hd2 (homo sapiens) (aka histone deacetylase 2)
B: hdhd2 (homo sapiens) (aka haloacid dehalogenase like hydrolase domain containing 2)
C: cep72 (homo sapiens) (aka centrosomal protein 72)
D: fap87 (homo sapiens) (aka ankyrin 2)
E: d2h (homo sa... | [K; K] |
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