instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: kip1 (homo sapiens) (cyclin dependent kinase inhibitor 1b (homo sapiens)) (aka cyclin dependent kinase inhibitor 1b)
C: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
D: kip2 (ho... | [D; N; B] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: cdkn1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1a)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo... | [K; C; E] |
<Instruct>: Given the context 'We describe a new CKI, p57KIP2, which is related to p21CIP1 and p27KIP1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1; p27kip1]
<Options>: A: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
B: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
C: kish2 (homo sapiens) (aka chromodomain helicase dna bin... | [J; I; L] |
<Instruct>: Given the context 'p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
B: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: kip2 (ho... | [D] |
<Instruct>: Given the context 'p57KIP2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
B: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
C: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
D: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calciu... | [E] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: tumor protein p53 (homo sapiens) (aka tumor protein p53)
B: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
C: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
D: cip2 (homo sapiens) ... | [N; K; A] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: tumor protein p53 (homo sapiens) (aka tumor protein p53)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: p-cip1 (homo sapiens) (aka ras association domain family member 9)
D: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin depende... | [N; D; A] |
<Instruct>: Given the context 'Unlike CIP1, KIP2 is not regulated by p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cip1; kip2; p53]
<Options>: A: p-cip1 (homo sapiens) (aka ras association domain family member 9)
B: ct53 (homo sapiens) (aka zinc finger protein 165)
C: tp73 (homo sapiens) (aka tumor protein p73)
D: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inh... | [D; H; G] |
<Instruct>: Given the context 'Overexpression of p57KIP2 arrests cells in G1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
B: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
C: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
D: p57kip2 (homo sapie... | [D] |
<Instruct>: Given the context 'Overexpression of p57KIP2 arrests cells in G1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
B: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: p27kip1 (homo sapiens) ... | [E] |
<Instruct>: Given the context 'p57KIP2 proteins have a complex structure.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
C: p-cip2 (homo sapiens) (aka u2af homology motif kinase 1)
D: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
E: calcium/calmodulin de... | [B] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: p27kip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
D: p27k (homo sapiens) (aka proteasome 20s subunit alpha ... | [H; F] |
<Instruct>: Given the context 'Mouse p57KIP2 consists of four structurally distinct domains: an amino-terminal Cdk inhibitory domain, a proline-rich domain, an acidic-repeat region, and a carboxy-terminal domain conserved with p27KIP1.', select the correct biomedical concept for each mention using the provided options.... | <Mentions>: [p57kip2; p27kip1]
<Options>: A: p27kip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1b (p27, kip1))
B: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
C: cdkn2 (homo sapiens) (cyclin dependent kinase 2 (homo sapiens)) (aka cyclin dependent kinase 2)
D: kip2 (homo sapiens) ... | [D; H] |
<Instruct>: Given the context 'Human p57KIP2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [p57kip2]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
D: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) ... | [A] |
<Instruct>: Given the context 'In situ hybridization during mouse embryogenesis revealed that KIP2 mRNA displays a striking pattern of expression during development, showing high level expression in skeletal muscle, brain, heart, lungs, and eye.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [kip2]
<Options>: A: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
B: cdkn2c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
C: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
D: kip2 (homo sapiens) (calcium and... | [A] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [kip2; p57kip2]
<Options>: A: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
B: kip2 (homo sapiens) (calcium and integrin binding family member 2 (homo sapiens)) (aka calcium and integrin binding family member 2)
C: cdkn2b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
D: calcium/c... | [G; G] |
<Instruct>: Given the context 'Most of the KIP2-expressing cells are terminally differentiated, suggesting that p57KIP2 is involved in decisions to exit the cell cycle during development and differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selec... | <Mentions>: [kip2; p57kip2]
<Options>: A: calcium/calmodulin dependent protein kinase ii inhibitor 2 (homo sapiens) (aka calcium/calmodulin dependent protein kinase ii inhibitor 2)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: kish2 (homo sapi... | [B; B] |
<Instruct>: Given the context 'Human KIP2 is located at 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, marking it as a candidate tumor suppressor.', select the correct biomedical concept for each mention using the provided options. Answer by listing th... | <Mentions>: [kip2]
<Options>: A: ing2 (homo sapiens) (inhibitor of growth family member 2 (homo sapiens)) (aka inhibitor of growth family member 2)
B: kip2 (homo sapiens) (cyclin dependent kinase inhibitor 1c (homo sapiens)) (aka cyclin dependent kinase inhibitor 1c)
C: p-cip2 (homo sapiens) (aka u2af homology motif ki... | [B] |
<Instruct>: Given the context 'The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [p21cip1]
<Options>: A: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
B: cip1 (homo sapiens) (cyclin dependent kinase inhibitor 1a (homo sapiens)) (aka cyclin dependent kinase inhibitor 1a)
C: p27kip1 (homo sapiens) (aka cyclin depen... | [B] |
<Instruct>: Given the context 'A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [interleukin-1 beta converting enzyme]
<Options>: A: casp2 (homo sapiens) (aka caspase 2)
B: caspase 7 (homo sapiens) (aka caspase 7)
C: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: ice (homo sapiens) (caspase 1 (hom... | [E] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp3 (homo sapiens) (aka caspase 3)
B: casp2 (homo sapiens) (aka caspase 2)
C: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
D: caspase 7 (homo sapiens) (aka caspase 7)
E: ice(rel)ii (homo sapiens) (aka caspase ... | [F; N; N] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: ice(rel)iii (homo sapiens) (aka caspase 5)
B: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
C: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
D: tx1 (arabidopsis thaliana) (aka mate efflux fa... | [F; I; I] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp1 (homo sapiens) (aka caspase 1)
B: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
C: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
D: tx1 (arabidopsis thaliana) (aka ... | [L; A; A] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [tx; interleukin-1 beta converting enzyme; ice]
<Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
C: tx (mus musculus) (aka atpase, copper transporting, beta polypeptide)
D: casp7 (homo sapiens) (aka caspase 7)... | [F; E; E] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [nedd-2; ich-1l]
<Options>: A: nedd3 (homo sapiens) (aka developmentally regulated gtp binding protein 1)
B: ich-1 (mus musculus) (aka caspase 2)
C: nedd2 (homo sapiens) (aka caspase 2)
D: nedd-8 (homo sapiens) (aka nedd8 ubiquitin like modifier)
E: ice1 (homo sapiens) (aka interactor of little elongation c... | [C; C] |
<Instruct>: Given the context 'We have identified a novel cDNA encoding a protein (named TX) with > 50% overall sequence identity with the interleukin-1 beta converting enzyme (ICE) and approximately 30% sequence identity with the ICE homologs NEDD-2/ICH-1L and CED-3.', select the correct biomedical concept for each me... | <Mentions>: [nedd-2; ich-1l]
<Options>: A: death regulator nedd2-like caspase (drosophila melanogaster) (aka death regulator nedd2-like caspase)
B: nedd1 (homo sapiens) (aka nedd1 gamma-tubulin ring complex targeting factor)
C: nedd-2 (homo sapiens) (aka caspase 2)
D: nedds (homo sapiens) (aka shq1, h/aca ribonucleopro... | [C; C] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: ice1 (homo sapiens) (aka interactor of little elongation complex ell subunit 1)
B: txs (homo sapiens) (aka thromboxane a synthase 1)
C: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
D: txl (homo sapiens) (aka thioredoxin like 1)
E: ice2 (homo sapiens) (aka interactor ... | [H; C] |
<Instruct>: Given the context 'A computer homology model of TX was constructed based on the X-ray coordinates of the ICE crystal recently published.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx; ice]
<Options>: A: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: ice (xenopus laevis) (caspase 1 s homeolog (xenopus laevis)) (aka caspase 1 s homeolog)
D: tx1 (xenopus tropicalis) (aka mab-21-like 3)
E: tx1 (ara... | [G; J] |
<Instruct>: Given the context 'This model suggests that TX is a cysteine protease, with the P1 aspartic acid substrate specificity retained.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tx]
<Options>: A: txs (homo sapiens) (aka thromboxane a synthase 1)
B: tx (homo sapiens) (aka caspase 4)
C: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
D: tx1 (xenopus tropicalis) (aka mab-21-like 3)
E: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
F: None of the above. | [B] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
B: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
C: txs (xenopus tropicalis) (aka thromboxane a synthase 1)
D: interleukin 1 beta (homo sapiens) (aka ... | [F; A; D; D] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: il-1a (homo sapiens) (aka interleukin 1 alpha)
B: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
C: tx1 (xenopus laevis) (aka mab-21-like 3 s homeolog)
D: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
E: il-1h... | [M; B; K; K] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: txn (xenopus laevis) (thioredoxin l homeolog (xenopus laevis)) (aka thioredoxin l homeolog)
B: il-1a (homo sapiens) (aka interleukin 1 alpha)
C: txs (homo sapiens) (aka thromboxane a synthase 1)
D: ich-2 (homo sapiens) (aka caspase 4)
E: ice2 (homo sapiens) ... | [O; L; P; P] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: ice (homo sapiens) (caspase 1 (homo sapiens)) (aka caspase 1)
B: ich-3 (homo sapiens) (aka caspase 5)
C: ice2 (homo sapiens) (aka interactor of little elongation complex ell subunit 2)
D: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
E: il1b (h... | [O; A; E; E] |
<Instruct>: Given the context 'Transfection experiments demonstrate that TX is a protease which is able to cleave itself and the p30 ICE precursor, but not to generate mature IL-1 beta from pro-IL-1 beta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected... | <Mentions>: [tx; ice; il-1 beta; pro-il-1 beta]
<Options>: A: il1b (homo sapiens) (aka interleukin 1 beta)
B: interleukin 36 beta (homo sapiens) (aka interleukin 36 beta)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: il-1a (homo sapiens) (aka interleukin 1 alpha)
E: txs (homo sapiens) (aka thromboxane a synt... | [F; J; A; A] |
<Instruct>: Given the context 'TX therefore delineates a new member of the growing Ice/ced-3 gene family coding for proteases with cytokine processing activity or involved in programmed cell death.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [tx]
<Options>: A: tx1 (xenopus tropicalis) (aka mab-21-like 3)
B: txs (homo sapiens) (aka thromboxane a synthase 1)
C: tx (homo sapiens) (aka caspase 4)
D: tx1 (arabidopsis thaliana) (aka mate efflux family protein)
E: tx (drosophila melanogaster) (aka taxi)
F: None of the above. | [C] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: es18 (homo sapiens) (aka programmed cell death 7)
B: lymphocyte antigen 6 family member h (homo sapiens) (aka lymphocyte antigen 6 family member h)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: lymphocyte antigen 6 family member k (homo sapien... | [J; K] |
<Instruct>: Given the context 'The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB, is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [e48 antigen; ly-6 antigen thb]
<Options>: A: lymphocyte antigen 86 (homo sapiens) (aka lymphocyte antigen 86)
B: cd6 molecule (homo sapiens) (aka cd6 molecule)
C: integrin subunit beta 6 (homo sapiens) (aka integrin subunit beta 6)
D: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
E: dee38 (homo sapi... | [F; K] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: desmoglein 2 (homo sapiens) (aka desmoglein 2)
B: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: dsg3 (homo sapiens) (aka desmoglein 3)
E: dg2/dg3 (homo sapiens) (aka desmocoll... | [J; D; D] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
B: dsc3 (homo sapiens) (desmocollin 3 (homo sapiens)) (aka desmocollin 3)
C: cdgs4 (homo sapiens) (aka alg3 alpha-1,3- mannosyltransferase)
D: dsg3 (homo sapiens) (aka desmoglein 3)
E: desmoglein 3 (sus scr... | [M; D; D] |
<Instruct>: Given the context 'The E48 antigen, a putative human homologue of the 20-kD protein present in desmosomal preparations of bovine muzzle, and formerly called desmoglein III (dg4), is a promising target antigen for antibody-based therapy of squamous cell carcinoma in man.', select the correct biomedical conce... | <Mentions>: [e48 antigen; desmoglein iii; dg4]
<Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: dgpx4 (drosophila melanogaster) (aka glutathione peroxidase homolog with thioredo... | [B; H; H] |
<Instruct>: Given the context 'A cDNA clone encoding the E48 antigen was isolated by expression cloning in COS cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
B: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
C: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
D: es18 (homo sapiens) (aka programmed cell death 7)
E: e48 (homo sapiens)... | [E] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', sel... | <Mentions>: [e48 antigen; thb]
<Options>: A: el18 (homo sapiens) (aka ribosomal protein l18)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: thbgb (homo sapiens) (aka pro-platelet basic protein)
D: thbs (bos taurus) (aka thrombospondin 1)
E: thb (mus musculus) (aka lymphocyte antigen 6 family member... | [B; E] |
<Instruct>: Given the context 'Sequence analysis revealed that the clone contained an open reading frame of 128 amino acids, encoding a core protein of 13,286 kD. Database searching showed that the E48 antigen has a high level of sequence similarity with the mouse ThB antigen, a member of the Ly-6 antigen family.', sel... | <Mentions>: [e48 antigen; thb]
<Options>: A: thbgb (homo sapiens) (aka pro-platelet basic protein)
B: tegument protein ul88 (human gammaherpesvirus 4) (aka tegument protein ul88)
C: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
D: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
E: tsh... | [G; F] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: dee38 (homo sapiens) (aka arv1 fatty acid homeostasis modulator)
B: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
C: dee18 (homo sapiens) (aka szt2 subunit of kicstor complex)
D: phosphatidylinositol pho... | [H; B] |
<Instruct>: Given the context 'Phosphatidylinositol-specific (PI-specific) phospholipase-C treatment indicated that the E48 antigen is glycosylphosphatidylinositol-anchored (GPI-anchored) to the plasma membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [phosphatidylinositol-specific (pi-specific) phospholipase-c; e48 antigen]
<Options>: A: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
B: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: plc-iv (homo sapien... | [F; C] |
<Instruct>: Given the context 'The gene encoding the E48 antigen is a single copy gene, located on human chromosome 8 in the 8q24-qter region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e48 antigen]
<Options>: A: dee48 (homo sapiens) (aka adaptor related protein complex 3 subunit beta 2)
B: mm28 (homo sapiens) (aka matrix metallopeptidase 28)
C: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
D: e47 (homo sapiens) (aka transcription factor 3)
E: tegument protein ul88 (human ... | [C] |
<Instruct>: Given the context 'The putative mouse homologue, the ThB antigen, originally identified as an antigen on cells of the lymphocyte lineage, was shown to be highly expressed in squamous mouse epithelia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [thb]
<Options>: A: tshb (bos taurus) (aka thyroid stimulating hormone subunit beta)
B: thbs (homo sapiens) (aka thrombospondin 1)
C: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
D: thbs (bos taurus) (aka thrombospondin 1)
E: thbgb (homo sapiens) (aka pro-platelet basic protein)
F: None of ... | [C] |
<Instruct>: Given the context 'Moreover, the ThB expression level is in keratinocytes, in contrast to that in lymphocytes, not mouse strain related.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [thb]
<Options>: A: thb (mus musculus) (aka lymphocyte antigen 6 family member d)
B: t cell receptor beta locus (homo sapiens) (aka t cell receptor beta locus)
C: tshb (homo sapiens) (aka thyroid stimulating hormone subunit beta)
D: thbd (bos taurus) (aka thrombomodulin)
E: thbs (homo sapiens) (aka thrombos... | [A] |
<Instruct>: Given the context 'Transfection of mouse SV40-polyoma transformed mouse NIH/3T3 cells with the E48 cDNA confirmed that the antigen is likely to be involved in cell-cell adhesion.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [e48]
<Options>: A: e46 (mus musculus) (aka ataxin 10)
B: e4f1 (homo sapiens) (aka e4f transcription factor 1)
C: e46l (homo sapiens) (aka ataxin 10)
D: e47 (homo sapiens) (aka transcription factor 3)
E: e48 (homo sapiens) (aka lymphocyte antigen 6 family member d)
F: None of the above. | [E] |
<Instruct>: Given the context 'Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, se... | <Mentions>: [peroxisomal targeting signal-1 receptor]
<Options>: A: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
B: peroxisomal targeting signal type 2 receptor (arabidopsis thaliana) (aka peroxin 7)
C: sphingosine-1-phosphate receptor 1 (xenopus tropicalis) (aka sphingosine-1-phosphate recep... | [D] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
B: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
C: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
D: pasd5 (homo sapiens) (aka neuronal pas domain protein 1)
E... | [A; H; A] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
B: pas8 (mus musculus) (aka pulmonary adenoma susceptibility 8)
C: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
D: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
E: pas... | [H; F; H] |
<Instruct>: Given the context 'We have cloned and sequenced the human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor (McCollum, D., E. Monosov, and S. Subramani.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [pts1r; pas8; pts1 receptor]
<Options>: A: pex1 (saccharomyces cerevisiae s288c) (aka aaa family atpase peroxin 1)
B: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
C: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
D: neuronal pas domain protein 4 (homo sapiens) (aka neuronal pa... | [F; I; F] |
<Instruct>: Given the context 'The PTS1R mRNA is expressed in all human tissues examined.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
B: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
E: pts1r (xenopus laevis) (ak... | [B] |
<Instruct>: Given the context 'Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1 (glycine max) (aka pterocarpan synthase)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
E: pts1r (homo sapiens) (aka peroxisoma... | [E] |
<Instruct>: Given the context 'Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
B: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
C: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
D: pts1 (glycine max) (aka pterocarpan synthase)
E: pts1r (xenopus laevis) (aka peroxisomal biogene... | [C] |
<Instruct>: Given the context 'Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
D: pts1r (homo sapiens) (aka peroxisomal biogenesis factor 5)
E: pts1r (... | [D] |
<Instruct>: Given the context 'In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
B: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
C: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
D: pts1 (glycine max) (aka pterocarpan synthase)
E: pex5r (homo sapiens) (aka peroxisomal biogenesi... | [B] |
<Instruct>: Given the context 'In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pts1r]
<Options>: A: pex5r (homo sapiens) (aka peroxisomal biogenesis factor 5 like)
B: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
C: pts1 (glycine max) (aka pterocarpan synthase)
D: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
E: None of the above. | [E] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: pasp (homo sapiens) (aka carboxypeptidase b1)
B: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
E: pts1-bp (homo sapiens) (... | [F; E] |
<Instruct>: Given the context 'A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pas8; pts1r]
<Options>: A: bhlha8 (homo sapiens) (aka neurogenin 2)
B: pts1r (mus musculus) (aka peroxisomal biogenesis factor 5)
C: pts1r (rattus norvegicus) (aka peroxisomal biogenesis factor 5)
D: pas3 (homo sapiens) (aka mucin 15, cell surface associated)
E: pts2r (homo sapiens) (aka peroxisomal biogen... | [I; G] |
<Instruct>: Given the context 'The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [pts1r]
<Options>: A: pts1-bp (homo sapiens) (aka peroxisomal biogenesis factor 5)
B: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
C: pts1r (xenopus laevis) (aka peroxisomal biogenesis factor 5 s homeolog)
D: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
E: pts2r... | [A] |
<Instruct>: Given the context 'The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon... | <Mentions>: [pts1r]
<Options>: A: pts-p1 (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase pseudogene)
B: pts2r (homo sapiens) (aka peroxisomal biogenesis factor 7)
C: pts (homo sapiens) (aka 6-pyruvoyltetrahydropterin synthase)
D: pts1 (glycine max) (aka pterocarpan synthase)
E: pts1r (homo sapiens) (aka peroxis... | [E] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: ntrk1 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: nt-3 (xenopus tropicalis) (aka neurotrophin 3)
D: neurotrophin-3 (gallus gallus) (aka neurotrophin 3)
E: ntf3 (homo sap... | [K; K; E] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: ntf3 (xenopus laevis) (neurotrophin 3 l homeolog (xenopus laevis)) (aka neurotrophin 3 l homeolog)
C: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
D: neurotrophin-3 (g... | [G; G; K] |
<Instruct>: Given the context 'Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
TrkC is a receptor tyrosine kinase that is activated by neurotrophin-3, a factor important in the development of certain areas of the central nervous system.', select the corre... | <Mentions>: [trkc; ntrk3; neurotrophin-3]
<Options>: A: ntrk3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
B: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
C: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
D: nt-3 (xenopus tropicalis) (aka neurotrophin 3)
E: ... | [A; A; E] |
<Instruct>: Given the context 'We have cloned and sequenced the human trkC cDNA and found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcine trkC sequences, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selecte... | <Mentions>: [trkc]
<Options>: A: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
B: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
C: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
D: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotro... | [D] |
<Instruct>: Given the context 'The rat trkC has several isoforms due to alternative splicing in the tyrosine kinase domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trkc (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
B: trkc (rattus norvegicus) (aka neurotrophic receptor tyrosine kinase 3)
C: trkc (mus musculus) (aka neurotrophic tyrosine kinase, receptor, type 3)
D: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
E:... | [A] |
<Instruct>: Given the context 'The human trkC cDNA also has a (CGG)n repeat in the 5'-untranslated region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [trkc]
<Options>: A: trk-b (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
B: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
C: neurotrophic receptor tyrosine kinase 3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
D: ntrkr3 (homo sapiens) (aka discoidin domain ... | [C] |
<Instruct>: Given the context 'By PCR analysis of a somatic cell hybrid panel and fluorescence in situ hybridization with the cDNA clone, human trkC was mapped to chromosome 15q24-q25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [trkc]
<Options>: A: ntrkr3 (homo sapiens) (aka discoidin domain receptor tyrosine kinase 2)
B: ntrk2 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 2)
C: trka (homo sapiens) (aka neurotrophic receptor tyrosine kinase 1)
D: ntrk3 (homo sapiens) (aka neurotrophic receptor tyrosine kinase 3)
E: trk... | [D] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using ... | <Mentions>: [fibulin-2; fbln2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
B: fbln (homo sapiens) (aka fibulin 1)
C: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracell... | [H; H] |
<Instruct>: Given the context 'Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and mapping of the gene on human and mouse chromosomes.
Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones.', select the correct biomedical concept for each mention using ... | <Mentions>: [fibulin-2; fbln2]
<Options>: A: fbln2 (sus scrofa) (aka fibulin 2)
B: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 2)
C: fibin (homo sapiens) (aka fin bud initiation factor homolog)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
... | [F; F] |
<Instruct>: Given the context 'Fibulin-2 mRNA is prominently expressed in mouse heart tissue and is present in low amounts in other tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-2]
<Options>: A: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
B: fibrillin 2 (homo sapiens) (aka fibrillin 2)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: fibulin 2 (sus scrofa) (aka fibulin 2)
E: fibulin 2 (homo ... | [E] |
<Instruct>: Given the context 'In this study, we isolated and sequenced a 4.1-kb human fibulin-2 cDNA, which encoded a mature protein of 1157 amino acids preceded by a 27-residue signal sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options,... | <Mentions>: [fibulin-2]
<Options>: A: fibin (homo sapiens) (aka fin bud initiation factor homolog)
B: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
C: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing... | [D] |
<Instruct>: Given the context 'The 115-residue C-terminal segment (domain III) is similar to the C variant of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: egf containing fibulin extracellular matrix protein 1 (homo sapiens) (aka egf containing fibulin extracellular matrix protein 1)
B: fibulin 5 (homo sapiens) (aka fibulin 5)
C: fibulin-1 (caenorhabditis elegans) (aka fibulin-1)
D: fbln1 (homo sapiens) (aka fibulin 1)
E: fibin (homo ... | [D] |
<Instruct>: Given the context 'The amino acid sequences of the human and mouse fibulin-2 share approximately 90% identity in domains Na, I, II, and III but only 62% identity in domain Nb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [fibulin-2]
<Options>: A: fibulin 2 (homo sapiens) (aka fibulin 2)
B: fibin (homo sapiens) (aka fin bud initiation factor homolog)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: egf containing fibulin extracellular matrix protein 2 (homo sapiens) (aka egf containi... | [A] |
<Instruct>: Given the context 'The expression pattern differs from that of fibulin-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fibulin-1]
<Options>: A: fib1 (homo sapiens) (aka dachsous cadherin-related 1)
B: fibrillin 1 (homo sapiens) (aka fibrillin 1)
C: fibulin 1 (homo sapiens) (aka fibulin 1)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: fibulin 2 (homo sapiens) (aka fibulin 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'The fibulin-2 gene was localized by in situ hybridization to the p24-p25 region of human chromosome 3 and to the band D-E of mouse chromosome 6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [fibulin-2]
<Options>: A: egf containing fibulin extracellular matrix protein 2 (sus scrofa) (aka egf containing fibulin extracellular matrix protein 2)
B: fibrillin 2 (homo sapiens) (aka fibrillin 2)
C: fibulin 2 (sus scrofa) (aka fibulin 2)
D: fibulin 5 (homo sapiens) (aka fibulin 5)
E: fbln2 (homo sapien... | [E] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tbp (bos taurus) (aka tata-box binding protein)
B: tbpa (homo sapiens) (aka transthyretin)
C: tar dna binding protein (bos taurus) (aka tar dna binding protein)
D: tata-box binding protein like 1 (xenopus tropicalis) (aka tata-box binding protein like 1)
E: tbp prot... | [F; F] |
<Instruct>: Given the context 'TFIID is a multisubunit protein complex comprised of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [tata-binding protein; tbp]
<Options>: A: tata-binding protein (saccharomyces cerevisiae s288c) (aka tata-binding protein)
B: tar dna binding protein (bos taurus) (aka tar dna binding protein)
C: tata-box binding protein (homo sapiens) (aka tata-box binding protein)
D: tata-box binding protein like 1 (xenop... | [C; C] |
<Instruct>: Given the context 'The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separa... | <Mentions>: [tafii55]
<Options>: A: tafii55 (homo sapiens) (aka tata-box binding protein associated factor 7)
B: tafii85 (homo sapiens) (aka tata-box binding protein associated factor 6)
C: tafii68 (homo sapiens) (aka tata-box binding protein associated factor 15)
D: taf5 (homo sapiens) (aka tata-box binding protein as... | [A] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: taf5 (homo sapiens) (aka tata-box binding protein associated factor 5)
B: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
C: yin-yang-1 (xenopus laevis) (yy1 transcription factor s homeolog (xenopus laevis)) (aka yy1 transcription factor s homeolo... | [Q; S; K; P] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: mt-sp1 (homo sapiens) (aka st14 transmembrane serine protease matriptase)
B: yy1 (homo sapiens) (aka yy1 transcription factor)
C: taf23 (saccharomyces cerevisiae s288c) (aka taf10p)
D: h-sp1 (homo sapiens) (aka synaptophysin like 1)
E: sp17-1 (homo sapiens) (aka s... | [O; P; G; B] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: taf5 (saccharomyces cerevisiae s288c) (aka chromatin modification protein)
B: yy1 (drosophila melanogaster) (aka pleiohomeotic)
C: yin-yang-1 (xenopus laevis) (yy1 transcription factor s homeolog (xenopus laevis)) (aka yy1 transcription factor s homeolog)
D: tafii... | [D; H; J; T] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: taf5 (saccharomyces cerevisiae s288c) (aka chromatin modification protein)
B: sp17-1 (homo sapiens) (aka sperm autoantigenic protein 17)
C: yy1 (drosophila melanogaster) (aka pleiohomeotic)
D: tafii55 (homo sapiens) (aka tata-box binding protein associated factor ... | [D; E; P; T] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [tafii55; tafii230; sp1; yy1]
<Options>: A: t-sp1 (homo sapiens) (aka serine protease 55)
B: yy1p1 (homo sapiens) (aka yy1 transcription factor pseudogene 1)
C: taf[[ii]]230 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
D: yy1 (homo sapiens) (a... | [N; Q; T; D] |
<Instruct>: Given the context 'TAFII55 is shown to interact with the largest subunit (TAFII230) of human TFIID through its central region and with multiple activators--including Sp1, YY1, USF, CTF, adenoviral E1A, and human immunodeficiency virus-type 1 Tat proteins--through a distinct amino-terminal domain.', select t... | <Mentions>: [usf]
<Options>: A: usf1 (homo sapiens) (aka upstream transcription factor 1)
B: usf1 (mus musculus) (aka upstream transcription factor 1)
C: usf3 (homo sapiens) (aka upstream transcription factor family member 3)
D: ush1f (homo sapiens) (aka protocadherin related 15)
E: usf1p (homo sapiens) (aka upstream t... | [A] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii100 (homo sapiens) (aka tata-box binding protein associated factor 5)
B: taf10 (saccharomyces cerevisiae s288c) (aka taf10p)
C: sp1 (xenopus tropicalis) (sp1 transcription factor (xenopus tropicalis)) (aka sp1 transcription factor)
D: tafii55 (homo sapiens) (aka t... | [D; N; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: t-sp1 (homo sapiens) (aka serine protease 55)
B: tafii170 (homo sapiens) (aka b-tfiid tata-box binding protein associated factor 1)
C: taf10 (saccharomyces cerevisiae s288c) (aka taf10p)
D: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)... | [H; K; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii55 (xenopus laevis) (aka tata-box binding protein associated factor 7 l homeolog)
B: sp1 (mus musculus) (aka trans-acting transcription factor 1)
C: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)
D: tafii55 (homo sapiens) (aka tata... | [D; M; P] |
<Instruct>: Given the context 'The TAFII55-interacting region of Sp1 was localized to its DNA-binding domain, which is distinct from the glutamine-rich activation domains previously shown to interact with Drosophila TAFII110.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [tafii55; sp1; tafii110]
<Options>: A: tafii55 (xenopus tropicalis) (aka tata-box binding protein associated factor 7)
B: sp1 (mus musculus) (aka trans-acting transcription factor 1)
C: sp1 (homo sapiens) (sp1 transcription factor (homo sapiens)) (aka sp1 transcription factor)
D: taf10 (saccharomyces cerevi... | [O; C; O] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [ergic-53; mr60]
<Options>: A: ergic-53 (xenopus tropicalis) (aka lectin, mannose binding 1)
B: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
C: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
D: ergic53 (drosophila melanogaster) (aka ergic53)
E: ct60 (homo sapiens) (ak... | [G; G] |
<Instruct>: Given the context 'ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [ergic-53; mr60]
<Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
C: ergic53 (homo sapiens) (aka lectin, mannose binding 1)
D: ergic-53l (homo sapiens) (aka lectin, mannose binding 1 li... | [C; C] |
<Instruct>: Given the context 'A mannose-specific membrane lectin (MR60) isolated from human myelomonocytic HL60 cells by affinity chromatography is expressed in intracellular organelles of immature monocytes (Pimpaneau, V., Midoux, P., Monsigny, M., and Roche, A. C. (1991) Carbohydr.', select the correct biomedical co... | <Mentions>: [mr60]
<Options>: A: rad60 (homo sapiens) (aka nuclear factor of activated t cells 2 interacting protein)
B: mrt60 (homo sapiens) (aka tata-box binding protein associated factor 13)
C: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
D: mr60 (homo sapiens) (aka lectin, mannose binding... | [D] |
<Instruct>: Given the context 'It is not present at the cell surface and is immunochemically and structurally distinct from the M(r) 175,000 mannose receptor of mature macrophages.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each m... | <Mentions>: [m(r) 175,000 mannose receptor of mature macrophages]
<Options>: A: mannose receptor, c type 1 (rattus norvegicus) (aka mannose receptor, c type 1)
B: mr (mus musculus) (mannose receptor, c type 1 (mus musculus)) (aka mannose receptor, c type 1)
C: mannose receptor c-type 1 (homo sapiens) (aka mannose recep... | [C] |
<Instruct>: Given the context 'MR60 cDNA was isolated and characterized; on the basis of its sequence, MR60 is not related to any known mammalian lectins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [mr60]
<Options>: A: ro60 (homo sapiens) (aka ro60, y rna binding protein)
B: mr60 (homo sapiens) (aka lectin, mannose binding 1)
C: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
D: cg6060 (drosophila melanogaster) (aka uncharacterized protein)
E: hel60 (homo sapiens) (aka aconitase 1)
F: None of the... | [B] |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [mr60; ergic-53]
<Options>: A: mr60 (mus musculus) (aka lectin, mannose-binding, 1)
B: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
C: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
D: hel60 (homo sapiens) (aka aconitase 1)
E: mr60 (homo sapiens) (aka lectin, mannos... | [E; E] |
<Instruct>: Given the context 'Surprisingly, MR60 was found to be identical to ERGIC-53 (Schindler, R., Itin, C., Zerial, M., Lottspeich, F., and Hauri, H.P. (1993)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [mr60; ergic-53]
<Options>: A: ergic-53l (xenopus tropicalis) (aka lectin, mannose-binding, 1 like)
B: ergic-53l (mus musculus) (aka complexin 3)
C: ergic53 (drosophila melanogaster) (aka ergic53)
D: er60 (homo sapiens) (aka protein disulfide isomerase family a member 3)
E: ro60 (homo sapiens) (aka ro60, y ... | [H; H] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)... | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: vip36-like (mus musculus) (aka lectin, mannose-binding 2-like)
B: ergic-63 (homo sapiens) (aka cytoskeleton associated protein 4)
C: vacuolar protein sorting 36 homolog (xenopus tropicalis) (aka vacuolar protein sorting 36 homolog)
D: ergic-53l (xenopus tropicalis) (ak... | [M; M; N] |
<Instruct>: Given the context '61, 1-9), a type I integral membrane protein, defined as a marker of the intermediate compartment that recycles between the Golgi apparatus and endoplasmic reticulum; MR60/ERGIC-53 shares with VIP-36 significant homologies with leguminous plant lectins (Fiedler, K., and Simmons, K. (1994)... | <Mentions>: [mr60; ergic-53; vip-36]
<Options>: A: ergic-32 (homo sapiens) (aka endoplasmic reticulum-golgi intermediate compartment 1)
B: ct60 (homo sapiens) (aka long intergenic non-protein coding rna 1193)
C: vip32 (xenopus tropicalis) (aka arginine vasopressin induced 1)
D: ro60 (homo sapiens) (aka ro60, y rna bind... | [I; I; H] |
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