instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [eaa4; glur6]
<Options>: A: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor kainate type subunit 2)
B: eap4 (homo sapiens) (aka exosome component 6)
C: eaat4 (homo sapiens) (aka solute carrier family 1 member 6)
D: glua4 (homo sapiens) (aka glutamate ionotropic receptor ampa type subunit 4)
E: ... | [F; F] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [humeaa4; glur6]
<Options>: A: esa4 (homo sapiens) (aka esterase a4)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4)
D: hypertension, essential, susceptibility to, 4 (homo sap... | [B; B] |
<Instruct>: Given the context 'A cDNA encoding an ionotropic glutamate receptor subunit protein humEAA4 (GluR6), has been cloned from a human fetal brain library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [humeaa4; glur6]
<Options>: A: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
B: glur-6 (xenopus laevis) (aka glutamate receptor, ionotropic, kainate 2 s homeolog)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: mglu6 (homo sapiens) (aka g... | [C; C] |
<Instruct>: Given the context 'We have successfully established cell lines stably expressing humEAA4 in HEK-293 cells This is the first report of the establishment of stable cell lines expressing a glutamate receptor channel.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [humeaa4]
<Options>: A: help4 (homo sapiens) (aka elongator acetyltransferase complex subunit 4)
B: esa4 (homo sapiens) (aka esterase a4)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: hypertension, essential, susceptibility to, 4 (homo sapiens) (aka hypertension, essen... | [C] |
<Instruct>: Given the context 'The relative potency of compounds for displacing [3H]-kainate binding to humEAA4 receptors expressed in COS or HEK-293 cells is domoate > kainate > quisqualate > 6-cyano-7-nitroquinoxaline-2,3-dione > L-glutamate = 6,7- dinitroquinoxaline-2,3-dione > dihydrokainate.', select the correct b... | <Mentions>: [humeaa4]
<Options>: A: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
B: eca4 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
C: hae4 (homo sapiens) (aka plasminogen)
D: esa4 (homo sapiens) (aka esterase a4)
E: eaa4 (homo sapiens) (aka glutamate ionotropic recep... | [E] |
<Instruct>: Given the context 'Applications of kainate, glutamate, and domoate but not AMPA evoked rapidly desensitizing currents in cells expressing homo-oligomeric humEAA4 in a concentration dependent manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the se... | <Mentions>: [humeaa4]
<Options>: A: enhancer of seven in absentia 4 (drosophila melanogaster) (aka enhancer of seven in absentia 4)
B: ele4 (homo sapiens) (aka regulatory region in intron 4 of pax6)
C: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
D: eca4 (homo sapiens) (aka gamma-amino... | [C] |
<Instruct>: Given the context 'Although AMPA did not itself activate humEAA4 receptors it did reduce, to a limited extent, kainate-evoked responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [humeaa4]
<Options>: A: saa4 (homo sapiens) (aka serum amyloid a4, constitutive)
B: eaa4 (homo sapiens) (aka glutamate ionotropic receptor kainate type subunit 2)
C: hae4 (homo sapiens) (aka plasminogen)
D: ela4 (homo sapiens) (aka chymotrypsin c)
E: enhancer of seven in absentia 4 (drosophila melanogaster)... | [B] |
<Instruct>: Given the context 'To date this effect has not been demonstrated with rat GluR6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glur6]
<Options>: A: glur6 (xenopus tropicalis) (aka glutamate receptor, ionotropic, kainate 2)
B: glur8 (homo sapiens) (aka glutamate metabotropic receptor 8)
C: glur-6 (mus musculus) (aka glutamate receptor, ionotropic, kainate 2 (beta 2))
D: glur6 (rattus norvegicus) (aka glutamate ionotropic receptor k... | [E] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: eck (mus musculus) (aka eph receptor a2)
B: src-like adaptor (mus musculus) (aka src-like adaptor)
C: cek7 (homo sapiens) (aka eph receptor a5)
D: src like adaptor (homo sapiens) (aka src like adaptor)
E: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
F: ... | [D; F] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: src like adaptor 2 (homo sapiens) (aka src like adaptor 2)
B: cek2 (homo sapiens) (aka fibroblast growth factor receptor 3)
C: src-like adaptor (mus musculus) (aka src-like adaptor)
D: srcl (homo sapiens) (aka collectin subfamily member 12)
E: eck (mus musculus) (aka ep... | [H; J] |
<Instruct>: Given the context 'Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [src-like adapter; eck]
<Options>: A: eck (homo sapiens) (aka eph receptor a2)
B: src like adaptor (sus scrofa) (aka src like adaptor)
C: eck (mus musculus) (aka eph receptor a2)
D: cek (homo sapiens) (aka fibroblast growth factor receptor 1)
E: srcap (homo sapiens) (aka snf2 related crebbp activator protei... | [G; A] |
<Instruct>: Given the context 'Using a yeast two-hybrid screen to identify molecules that interact with the cytoplasmic domain of Eck, it was previously shown that activated Eck RPTK bound to and stimulated phosphatidylinositol 3-kinase (Pandey, A., Lazar, D.F., Saltiel, A. R., and Dixit, V.M. (1994) J. Biol.', select ... | <Mentions>: [eck]
<Options>: A: ek (homo sapiens) (choline kinase beta (homo sapiens)) (aka choline kinase beta)
B: eck (homo sapiens) (aka eph receptor a2)
C: cek (homo sapiens) (aka fibroblast growth factor receptor 1)
D: etk (escherichia coli str. k-12 substr. mg1655) (aka protein-tyrosine kinase etk)
E: cek2 (homo ... | [B] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: src-like adaptor (mus musculus) (aka src-like adaptor)
B: sla1p (homo sapiens) (aka src like adaptor)
C: src like adaptor 2 (homo sapiens) (aka src like adaptor 2)
D: slan (homo sapiens) (aka secis binding protein 2 like)
E: srcap (homo sapiens) (aka snf2 related crebb... | [B; B] |
<Instruct>: Given the context 'Hence, this protein was designated SLAP for Src-like adapter protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [slap; src-like adapter]
<Options>: A: slap-2 (homo sapiens) (aka src like adaptor 2)
B: sla- (sus scrofa) (aka mhc class i antigen 1)
C: src like adaptor (sus scrofa) (aka src like adaptor)
D: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
E: srcap (homo sapiens) ... | [H; H] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [slap; eck]
<Options>: A: sla (homo sapiens) (src like adaptor (homo sapiens)) (aka src like adaptor)
B: slap-2 (homo sapiens) (aka src like adaptor 2)
C: ehk-2 (homo sapiens) (aka eph receptor a6)
D: slap (homo sapiens) (sarcolemma associated protein (homo sapiens)) (aka sarcolemma associated protein)
E: e... | [A; G] |
<Instruct>: Given the context 'Using glutathione S-transferase fusion Proteins, it was demonstrated that SLAP bound to activated Eck receptor tyrosine kinase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by s... | <Mentions>: [slap; eck]
<Options>: A: ecfk (escherichia coli str. k-12 substr. mg1655) (aka outer membrane protein assembly factor bama)
B: sla- (sus scrofa) (aka mhc class i antigen 1)
C: sla1p (homo sapiens) (aka src like adaptor)
D: eck (mus musculus) (aka eph receptor a2)
E: ehk-2 (homo sapiens) (aka eph receptor a... | [C; F] |
<Instruct>: Given the context 'Therefore, SLAP is a novel candidate downstream signaling intermediate and the first member of the Src family that resembles an adapter molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each menti... | <Mentions>: [slap]
<Options>: A: sla1p (homo sapiens) (aka src like adaptor)
B: slap2 (homo sapiens) (aka src like adaptor 2)
C: slat (homo sapiens) (aka def6 guanine nucleotide exchange factor)
D: sla/lp (homo sapiens) (aka sep (o-phosphoserine) trna:sec (selenocysteine) trna synthase)
E: slap (homo sapiens) (sarcolem... | [A] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and... | <Mentions>: [cb1; cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cb1 (mus musculus) (aka cannabinoid receptor 1)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cannabinoid receptor 2 (homo sap... | [G; D] |
<Instruct>: Given the context 'Two proteins with seven transmembrane-spanning domains typical of guanosine-nucleotide-binding-protein-coupled receptors have been identified as cannabinoid receptors; the central cannabinoid receptor, CB1, and the peripheral cannabinoid receptor, CB2, initially described in rat brain and... | <Mentions>: [cb1; cb2]
<Options>: A: cb1a (mus musculus) (aka cannabinoid receptor 1)
B: cb2 (homo sapiens) (aka cannabinoid receptor 2)
C: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: corticotropin releasing hormone receptor 2... | [G; B] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [cb1; cb2]
<Options>: A: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cb1r (mus musculus) (aka cannabinoid receptor 1)
E: ca... | [F; E] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor... | [G; F] |
<Instruct>: Given the context 'Here, we report the distribution patterns for both CB1 and CB2 transcripts in human immune cells and in several human tissues, as analysed using a highly sensitive and quantitative PCR-based method.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [cb1; cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
D: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
E: cb1 (mu... | [C; H] |
<Instruct>: Given the context 'CB1 was mainly expressed in the central nervous system and, to a lower extent, in several peripheral tissues such as adrenal gland, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus and tonsils.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [cb1]
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1)
B: cb1 (homo sapiens) (aka cannabinoid receptor 1)
C: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
D: None of the above. | [B] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cb2; cb1]
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
E: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
F: g... | [A; H] |
<Instruct>: Given the context 'In contrast, the CB2 gene, which is not expressed in the brain, was particularly abundant in immune tissues, with an expression level 10-100-fold higher than that of CB1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [cb2; cb1]
<Options>: A: cb1r (mus musculus) (aka cannabinoid receptor 1)
B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
C: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
D: cb2 (homo sapiens) (aka cannabinoid receptor 2)
E: gprchr2 (homo sapiens) (aka g protein-coupled receptor 7... | [D; F] |
<Instruct>: Given the context 'Although CB2 mRNA was also detected in some other peripheral tissues, its level remained very low.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
B: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: gprchr2 (homo sapi... | [A] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
B: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
C: cc-ckr-2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
E: can... | [E; A] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
B: cb1 (mus musculus) (aka cannabinoid receptor 1)
C: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
D: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
E: gababr2 (homo s... | [G; C] |
<Instruct>: Given the context 'In spleen and tonsils, the CB2 mRNA content was equivalent to that of CB1 mRNA in the central nervous system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2; cb1]
<Options>: A: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: gprchr2 (homo sapiens) (aka g protein-cou... | [H; A] |
<Instruct>: Given the context 'Among the main human blood cell subpopulations, the distribution pattern of the CB2 mRNA displayed important variations.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [cb2]
<Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: cannabinoid receptor 2 (homo sapiens) (aka cannab... | [D] |
<Instruct>: Given the context 'The rank order of CB2 mRNA levels in these cells was B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for... | <Mentions>: [cb2]
<Options>: A: cb2 (homo sapiens) (aka cannabinoid receptor 2)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E... | [A] |
<Instruct>: Given the context 'The prevailing expression of the CB2 gene in immune tissues was confirmed by Northern-blot analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cb2]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
E: cb2 (homo sapiens... | [E] |
<Instruct>: Given the context 'In addition, the expression of the CB2 protein was demonstrated by an immunohistological analysis performed on tonsil sections using specific anti-(human CB2) IgG; this experiment showed that CB2 expression was restricted to B-lymphocyte-enriched areas of the mantle of secondary lymphoid ... | <Mentions>: [cb2]
<Options>: A: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
C: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: gprc2b (homo sapiens) (aka... | [B] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct bi... | <Mentions>: [cb1; cb2]
<Options>: A: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
C: cb1a (mus musculus) (aka cannabinoid receptor 1)
D: cb1a (homo sapiens) (aka cannabinoid receptor 1)
E: cc-ckr-2 (homo... | [D; G] |
<Instruct>: Given the context 'These results suggest that (a) CB1 and CB2 can be considered as tissue-selective antigens of the central nervous system and immune system, respectively, and (b) cannabinoids may exert specific receptor-mediated actions on the immune system through the CB2 receptor.', select the correct bi... | <Mentions>: [cb1; cb2]
<Options>: A: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
B: cb1r (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E... | [G; H] |
<Instruct>: Given the context 'Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
B: prokr2 (homo sapiens) (aka prokineticin receptor 2)
C: coagulation factor ii thrombin receptor like 2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
D: proteinase-activate... | [E] |
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: f2r like thrombin or trypsin receptor 3 (homo sapiens) (aka f2r like thrombin or trypsin receptor 3)
B: par2 (homo sapiens) (f2r like trypsin receptor 1 (homo sapiens)) (aka f2r like trypsin receptor 1)
C: f2rl2 (homo sapiens) (aka coagulation factor ii thromb... | [B] |
<Instruct>: Given the context 'Since the physiological agonist was unknown, the receptor was named proteinase-activated receptor 2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like)
B: f2r (homo sapiens) (aka coagulation factor ii thrombin receptor)
C: f2rl2 (homo sapiens) (aka coagulation factor ii thrombin receptor like 2)
D: f2r like thrombi... | [E] |
<Instruct>: Given the context 'By fluorescence in situ hybridization, the human proteinase-activated receptor 2 gene was mapped to chromosomal region 5q13, where, previously, the related thrombin receptor gene has been located.', select the correct biomedical concept for each mention using the provided options. Answer ... | <Mentions>: [proteinase-activated receptor 2]
<Options>: A: prokr2 (homo sapiens) (aka prokineticin receptor 2)
B: proteinase-activated receptor 2-like (gallus gallus) (aka proteinase-activated receptor 2-like)
C: par3 (homo sapiens) (coagulation factor ii thrombin receptor like 2 (homo sapiens)) (aka coagulation facto... | [E] |
<Instruct>: Given the context 'We have described a protein (Hep27)', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
B: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
C: es27 (homo sapiens) (aka ribosomal protein s27)
D: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
E: hh27 (homo sapiens) (aka nescient helix-... | [A] |
<Instruct>: Given the context 'The synthesis of Hep27 is inhibited in cells that, released from the butyrate block, have resumed DNA synthesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
D: es27 (homo sapiens) (aka ribosomal protein s27)
E: hel-s-27 (homo sapiens) (aka serpin family b m... | [B] |
<Instruct>: Given the context 'This report describes the cloning and the characterization of the cDNA coding for the Hep27 protein.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: es27 (homo sapiens) (aka ribosomal protein s27)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
D: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
E: lc27 (homo sapiens) (aka lysosomal prote... | [B] |
<Instruct>: Given the context 'The translation of the Hep27 cDNA predicts an amino acid sequence that can be aligned with those of the known short-chain alcohol dehydrogenase enzymes (SCAD) family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected option... | <Mentions>: [hep27]
<Options>: A: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: es27 (homo sapiens) (aka ribosomal protein s27)
D: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
E: hel-s-27 (homo sapiens) (aka serpin family b member 1)
F: N... | [B] |
<Instruct>: Given the context 'In agreement with its nuclear localization Hep27 has a region similar to the bipartite nuclear-targeting sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: ncc27 (homo sapiens) (aka chloride intracellular channel 1)
B: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
C: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
D: gp27 (homo sapiens) (aka cd151 molecule (raph blood group))
E: hep27 (mus musculus) (aka dehydrogen... | [B] |
<Instruct>: Given the context 'The study of Hep27 mRNA expression and protein synthesis suggests the existence of a regulation at the post-transcriptional level.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [hep27]
<Options>: A: lc27 (homo sapiens) (aka lysosomal protein transmembrane 4 beta)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: hh27 (homo sapiens) (aka nescient helix-loop-helix 2)
D: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
E: hcp27 (homo sapiens) (aka cycs pseudogene ... | [D] |
<Instruct>: Given the context 'The possible nuclear role of the Hep27 protein is discussed.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hep27]
<Options>: A: hsf-27 (homo sapiens) (aka cdk5 regulatory subunit associated protein 3)
B: hep27 (mus musculus) (aka dehydrogenase/reductase member 2)
C: hep27 (homo sapiens) (aka dehydrogenase/reductase 2)
D: hcp27 (homo sapiens) (aka cycs pseudogene 27)
E: lc27 (homo sapiens) (aka lysosomal protein... | [C] |
<Instruct>: Given the context 'Human papillomaviruses (HPVs) are associated with the majority of cervical cancers and encode a transforming protein, E6, that interacts with the tumor suppressor protein p53.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [p53]
<Options>: A: rad53 (homo sapiens) (aka checkpoint kinase 2)
B: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
C: p53 (homo sapiens) (aka tumor protein p53)
D: ct53 (homo sapiens) (aka zinc finger protein 165)
E: p53cp (homo sapiens) (aka tumor pro... | [C] |
<Instruct>: Given the context 'Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [p53]
<Options>: A: p53 (homo sapiens) (aka tumor protein p53)
B: tumor protein p73 (homo sapiens) (aka tumor protein p73)
C: ct53 (homo sapiens) (aka zinc finger protein 165)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein li... | [A] |
<Instruct>: Given the context 'Because E6 has p53-independent transforming activity, the yeast two-hybrid system was used to search for other E6-binding proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [p53]
<Options>: A: ct53 (homo sapiens) (aka zinc finger protein 165)
B: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
C: tumor protein p73 (homo sapiens) (aka tumor protein p73)
D: rad53 (homo sapiens) (aka checkpoint kinase 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'One such protein, E6BP, interacted with cancer-associated HPV E6 and with bovine papillomavirus type 1 (BPV-1) E6.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: ebbp (homo sapiens) (aka tripartite motif containing 16)
B: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
C: protein e6*;transforming protein e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
D: e6-ap (homo sapiens) (aka ubiquitin protein ligase... | [E] |
<Instruct>: Given the context 'The transforming activity of BPV-1 E6 mutants correlated with their E6BP-binding ability.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [e6bp]
<Options>: A: e6bp (homo sapiens) (aka reticulocalbin 2)
B: ubc6p (homo sapiens) (aka ubiquitin conjugating enzyme e2 j1)
C: transforming protein e5 (human papillomavirus 16) (aka transforming protein e5)
D: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
E: protein e6*;transformin... | [A] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [e6bp; erc-55]
<Options>: A: rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
B: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
C: 16e1bp (homo sapiens) (aka thyroid hormone receptor interactor 13)
D: testis expressed 55 (xenopus tropicalis) (aka testis ... | [E; E] |
<Instruct>: Given the context 'E6BP is identical to a putative calcium-binding protein, ERC-55, that appears to be localized in the endoplasmic reticulum.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semic... | <Mentions>: [e6bp; erc-55]
<Options>: A: ercc excision repair 5, endonuclease (homo sapiens) (aka ercc excision repair 5, endonuclease)
B: rad55 (saccharomyces cerevisiae s288c) (aka putative dna-dependent atpase rad55)
C: e3bp (homo sapiens) (aka pyruvate dehydrogenase complex component x)
D: e6bp (homo sapiens) (aka ... | [D; D] |
<Instruct>: Given the context 'A phosphoinositide-3 kinase isotype, p110 gamma, was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p110 gamma]
<Options>: A: p110gamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
B: p110beta (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)
C: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-ki... | [A] |
<Instruct>: Given the context 'The p110 gamma enzyme was activated in vitro by both the alpha and beta gamma subunits of heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) and did not interact with p85.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [p110 gamma]
<Options>: A: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
B: p110gamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
C: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gam... | [D] |
<Instruct>: Given the context 'The p110 gamma isotype may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers phosphorylated in the D-3 position.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [p110 gamma]
<Options>: A: p110gamma (mus musculus) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
B: p110-alpha (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
C: p110gamma (homo sapiens) (aka phosphatidylinositol-4,5-bisphosphate 3-... | [C] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: znf141 (homo sapiens) (zinc finger protein 141 (homo sapiens)) (aka zinc finger protein 141)
B: ct136 (homo sapiens) (aka outer dense fiber of sperm tails 4)
C: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
D: lethal (1) ts136 (drosophila melanog... | [N; L; E] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: rnf140 (homo sapiens) (aka deltex e3 ubiquitin ligase 1)
B: znf40a (homo sapiens) (aka hivep zinc finger 1)
C: lethal (1) ts136 (drosophila melanogaster) (aka lethal (1) ts136)
D: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
E: znf141 (homo sapi... | [H; J; G] |
<Instruct>: Given the context 'ZNF133 and ZNF140 have both the KRAB A- and KRAB B-boxes present at their N-terminus, whereas ZNF136 contains only the KRAB A-box.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140; znf136]
<Options>: A: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
B: znf400 (homo sapiens) (aka zdhhc palmitoyltransferase 12)
C: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
D: rnf133 (homo sapiens) (aka ring finger protein 133)
E: fam161 ho... | [L; J; F] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140]
<Options>: A: zinc finger protein 140 (homo sapiens) (aka zinc finger protein 140)
B: zinc finger protein 135 (homo sapiens) (aka zinc finger protein 135)
C: znf139 (homo sapiens) (aka zinc finger with krab and scan domains 1)
D: zinc finger protein 195 (homo sapiens) (aka zinc finger prote... | [J; A] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140]
<Options>: A: rnf133 (homo sapiens) (aka ring finger protein 133)
B: znf132 (homo sapiens) (aka zinc finger protein 132)
C: znf133 (homo sapiens) (aka zinc finger protein 133)
D: zinc finger protein 195 (homo sapiens) (aka zinc finger protein 195)
E: znf400 (homo sapiens) (aka zdhhc palmito... | [C; J] |
<Instruct>: Given the context 'We have previously demonstrated that the KRAB domains derived from ZNF133 and ZNF140 are potent transcriptional repression domains', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [znf133; znf140]
<Options>: A: znf404 (homo sapiens) (aka zinc finger protein 404)
B: zinc finger protein 133 (homo sapiens) (aka zinc finger protein 133)
C: znf40a (homo sapiens) (aka hivep zinc finger 1)
D: bzip133 (glycine max) (aka putative bzip domain class transcription factor)
E: zinc finger protein ... | [B; J] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: kox6 (homo sapiens) (aka zinc finger protein 14)
B: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
C: kox10 (homo sapiens) (aka zinc finger protein 17)
D: znf10 (homo sapiens) (aka zinc finger protein 10)
E: kox7 (homo sapiens) (aka zinc finger protein 44... | [G; D; D] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: kox8 (homo sapiens) (aka zinc finger protein 708)
B: rnf136 (homo sapiens) (aka baculoviral iap repeat containing 8)
C: znf10 (homo sapiens) (aka zinc finger protein 10)
D: zinc finger protein 136 (homo sapiens) (aka zinc finger protein 136)
E: zinc finger and scan domain... | [D; C; C] |
<Instruct>: Given the context 'The KRAB domain from ZNF136, containing only subdomain A, is a considerable weaker suppression domain; however, when fused to the heterologous KRAB B subdomain of ZNF10 (KOX1) the two subdomains from a KRAB domain which induces repression as potently as previously reported KRAB domains.',... | <Mentions>: [znf136; znf10; kox1]
<Options>: A: phz-10 (homo sapiens) (aka zinc finger protein 131)
B: zinc finger protein 236 (homo sapiens) (aka zinc finger protein 236)
C: kox-1 (homo sapiens) (aka nadph oxidase 4)
D: zinc finger protein 10-like (glycine max) (aka zinc finger protein 10-like)
E: kox3 (homo sapiens) ... | [F; I; I] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scn1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
B: scn5a (sus scrofa) (aka sodium voltage-gated channel alpha subunit 5)
C: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
D: enacalpha (ho... | [F; F] |
<Instruct>: Given the context 'One form of hereditary long QT (LQT3) has been linked to a mutation in the gene encoding the human heart voltage-gated sodium-channel alpha-subunit (SCN5A on chromosome 3p21).', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [heart voltage-gated sodium-channel alpha-subunit; scn5a]
<Options>: A: scnn1a (homo sapiens) (aka sodium channel epithelial 1 subunit alpha)
B: scn1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 1)
C: scn5a (mus musculus) (aka sodium channel, voltage-gated, type v, alpha)
D: sodium voltag... | [F; F] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp80 (homo sapiens) (aka nuclear cap binding protein subunit 1)
B: cbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
C: cbp80 (drosophila melanogaster) (aka cap binding protein 80)
D: eukaryotic translation initiation factor 4h (homo sapiens) (aka eukary... | [L; A; N] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: nuclear cap-binding protein cbp80 (arabidopsis thaliana) (aka arm repeat superfamily protein)
B: cap binding protein 20 (drosophila melanogaster) (aka cap binding protein 20)
C: eif-4e (homo sapiens) (aka eukaryotic translation initiation factor 4e)
D: cbp86 (homo sapien... | [C; O; G] |
<Instruct>: Given the context 'The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC) composed of two cap binding proteins, CBP80 and CBP20.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [eif-4f; cbp80; cbp20]
<Options>: A: cbp20 (saccharomyces cerevisiae s288c) (aka nuclear cap-binding protein subunit cbc2)
B: eukaryotic translation initiation factor 4e-4 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-4)
C: cbp20 (homo sapiens) (aka nuclear cap binding protein su... | [O; I; C] |
<Instruct>: Given the context 'Antibodies against recombinant CBP20 prevent interaction of CBC with capped RNAs in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cbp20]
<Options>: A: cbp20 (xenopus laevis) (aka nuclear cap binding protein subunit 2 l homeolog)
B: cbp20 (drosophila melanogaster) (aka cap binding protein 20)
C: cbp20 (homo sapiens) (aka nuclear cap binding protein subunit 2)
D: small subunit processome component 20 homolog (glycine max) (aka small su... | [C] |
<Instruct>: Given the context 'Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [carboxypeptidase e]
<Options>: A: carboxypeptidase o (homo sapiens) (aka carboxypeptidase o)
B: carboxypeptidase e (sus scrofa) (aka carboxypeptidase e)
C: carboxypeptidase e (rattus norvegicus) (aka carboxypeptidase e)
D: carboxypeptidase e (mus musculus) (aka carboxypeptidase e)
E: carboxypeptidase e (ga... | [D] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (xenopus tropicalis) (aka carboxypeptidase e)
B: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e)
C: cpepe (drosophila melanogaster) (aka silver)
D: carboxypeptidase e (rattus norvegicus) (aka carboxypeptidase e)
E: carboxypeptidase e (ca... | [I; I] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e)
B: cpepe (drosophila melanogaster) (aka silver)
C: cpetr (homo sapiens) (aka claudin 4)
D: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
E: carboxypeptidase e (sus scrofa) (aka ... | [H; H] |
<Instruct>: Given the context 'The fat mutation maps to mouse chromosome 8, very close to the gene for carboxypeptidase E (Cpe), which encodes an enzyme (CPE) that processes prohormone intermediates such as proinsulin.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [carboxypeptidase e; cpe]
<Options>: A: cpepe (drosophila melanogaster) (aka silver)
B: cpetr (homo sapiens) (aka claudin 4)
C: carboxypeptidase e (sus scrofa) (aka carboxypeptidase e)
D: carboxypeptidase e (xenopus tropicalis) (aka carboxypeptidase e)
E: carboxypeptidase e (oryctolagus cuniculus) (cpe (ory... | [I; I] |
<Instruct>: Given the context 'We now demonstrate a defect in proinsulin processing associated with the virtual absence of CPE activity in extracts of fat/fat pancreatic islets and pituitaries.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [cpe]
<Options>: A: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
B: cpepe (drosophila melanogaster) (aka silver)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: cpetr (homo sapiens) (aka claudin 4)
E: cpeb (homo sapiens) (aka cytoplasmic polyade... | [F] |
<Instruct>: Given the context 'A single Ser202Pro mutation distinguishes the mutant Cpe allele, and abolishes enzymatic activity in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cpe]
<Options>: A: cpe (gallus gallus) (aka carboxypeptidase e)
B: cpea (escherichia coli str. k-12 substr. mg1655) (aka exodeoxyribonuclease i)
C: cpe1 (homo sapiens) (aka cytochrome p450 family 2 subfamily e member 1)
D: cpe (homo sapiens) (aka carboxypeptidase e)
E: cper (homo sapiens) (aka claudin 4)
F... | [F] |
<Instruct>: Given the context 'A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (sus scrofa) (aka translin)
B: translin (danio rerio) (aka translin)
C: translin (glycine max) (aka translin)
D: translin (xenopus tropicalis) (aka translin)
E: translin (homo sapiens) (aka translin)
F: None of the above. | [E] |
<Instruct>: Given the context 'We have identified a novel gene, Translin, encoding a protein which specifically binds to consensus sequences at breakpoint junctions of chromosomal translocations in many cases of lymphoid malignancies.', select the correct biomedical concept for each mention using the provided options. ... | <Mentions>: [translin]
<Options>: A: translin-like (bos taurus) (aka translin-like)
B: translin (homo sapiens) (aka translin)
C: translin (xenopus tropicalis) (aka translin)
D: translin (glycine max) (aka translin)
E: translin (sus scrofa) (aka translin)
F: None of the above. | [B] |
<Instruct>: Given the context 'The encoded protein, Translin, is a previously undescribed type with no significant similarity to known proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [translin]
<Options>: A: translin (homo sapiens) (aka translin)
B: translin-like (bos taurus) (aka translin-like)
C: translin (glycine max) (aka translin)
D: translin (mus musculus) (aka translin)
E: translin (drosophila melanogaster) (aka translin)
F: None of the above. | [A] |
<Instruct>: Given the context 'In the native form, Translin polypeptides form a multimeric structure which is responsible for its DNA binding activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [translin]
<Options>: A: translin-like (xenopus tropicalis) (aka translin-like)
B: translin (homo sapiens) (aka translin)
C: translin (xenopus tropicalis) (aka translin)
D: translin (danio rerio) (aka translin)
E: translin (mus musculus) (aka translin)
F: None of the above. | [B] |
<Instruct>: Given the context 'Nuclear localization of Translin is limited to lymphoid cell lines, raising the intriguing possibility that nuclear transport of Translin is regulated in a physiologically significant way such that active nuclear transport is associated with the lymphoid specific process known as Ig/TCR g... | <Mentions>: [translin]
<Options>: A: translin (danio rerio) (aka translin)
B: translin-like (xenopus tropicalis) (aka translin-like)
C: translin (bos taurus) (aka translin)
D: translin (homo sapiens) (aka translin)
E: translin (glycine max) (aka translin)
F: None of the above. | [D] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: adn (homo sapiens) (aka complement factor d)
B: dctn-50 (mus musculus) (aka dynactin 2)
C: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
D: adhalin (homo sapiens) (aka sarcoglycan alpha)
E: anln (homo sapiens) (aka anillin... | [D; D] |
<Instruct>: Given the context 'Marked deficiency of muscle adhalin, a 50 kDa sarcolemmal dystrophin-associated glycoprotein, has been reported in severe childhood autosomal recessive muscular dystrophy (SCARMD).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [adhalin; 50 kda sarcolemmal dystrophin-associated glycoprotein]
<Options>: A: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
B: 35kda (mus musculus) (sarcoglycan, gamma (dystrophin-associated glycoprotein) (mus musculus)) (aka sarcoglycan, gamma (dystrophin-associated glycoprotein))
C: 50dag (... | [I; I] |
<Instruct>: Given the context 'Adhalin deficiency has been found in SCARMD patients from North Africa Europe, Brazil, Japan and North America (SLR & KPC, unpublished data).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, ... | <Mentions>: [adhalin]
<Options>: A: arcadlin (homo sapiens) (aka protocadherin 8)
B: adhalin (homo sapiens) (aka sarcoglycan alpha)
C: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
D: apln (homo sapiens) (aka apelin)
E: adn (homo sapiens) (aka complement factor d)
F: None of the above. | [B] |
<Instruct>: Given the context 'The disease was initially linked to an unidentified gene on chromosome 13 in families from North Africa, and to the adhalin gene itself on chromosome 17q in one French family in which missense mutations were identified.', select the correct biomedical concept for each mention using the pr... | <Mentions>: [adhalin]
<Options>: A: adhalin (homo sapiens) (aka sarcoglycan alpha)
B: ankyrin-1-like (danio rerio) (aka ankyrin-1-like)
C: apln (homo sapiens) (aka apelin)
D: dystonin (homo sapiens) (aka dystonin)
E: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
F: None of the above. | [A] |
<Instruct>: Given the context 'Thus there are two kinds of myopathies with adhalin deficiency: one with a primary defect of adhalin (primary adhalinopathies), and one in which absence of adhalin is secondary to a separate gene defect on chromosome 13.', select the correct biomedical concept for each mention using the p... | <Mentions>: [adhalin]
<Options>: A: apln (homo sapiens) (aka apelin)
B: adhalin (xenopus laevis) (aka sarcoglycan alpha l homeolog)
C: adhalin (homo sapiens) (aka sarcoglycan alpha)
D: anillin, actin binding protein (homo sapiens) (aka anillin, actin binding protein)
E: adn (homo sapiens) (aka complement factor d)
F: N... | [C] |
<Instruct>: Given the context 'We have examined the importance of primary adhalinopathies among myopathies with adhalin deficiency, and describe several additional mutations (null and missense) in the adhalin gene in 10 new families from Europe and North Africa.', select the correct biomedical concept for each mention ... | <Mentions>: [adhalin]
<Options>: A: adhalin (homo sapiens) (aka sarcoglycan alpha)
B: anln (homo sapiens) (aka anillin, actin binding protein)
C: adhalin (xenopus tropicalis) (aka sarcoglycan alpha)
D: apln (homo sapiens) (aka apelin)
E: dystonin (homo sapiens) (aka dystonin)
F: None of the above. | [A] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
B: ckr-1 (homo sapiens) (c-c motif chemokine receptor 1 (homo sapiens)) (aka c-c motif chemokine receptor 1)
C: mip1ap (homo sapiens) (aka c-c motif che... | [B; B] |
<Instruct>: Given the context 'Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage inflammatory protein 1 alpha; rantes receptor]
<Options>: A: c-c motif chemokine receptor 3 (homo sapiens) (aka c-c motif chemokine receptor 3)
B: c-c motif chemokine receptor 2 (homo sapiens) (aka c-c motif chemokine receptor 2)
C: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
D: c-... | [J; J] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', se... | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
C: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
D: mip-1d (homo sapiens) (aka c-c motif ch... | [I; I] |
<Instruct>: Given the context 'The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the growth of hematopoietic stem cells.', se... | <Mentions>: [macrophage inflammatory protein 1 alpha; mip-1 alpha]
<Options>: A: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
B: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
C: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
D: mip-3a... | [I; I] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-3b (homo sapiens) (aka c-c motif chemokine ligand 19)
B: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
C: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
D: rantes (sus scrofa... | [O; J; J] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mcp-3 (homo sapiens) (aka c-c motif chemokine ligand 7)
B: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
C: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
D: mip3b (homo sapiens) (aka c-c motif chemokine ligand 19)
E: mip1ap (... | [O; J; J] |
<Instruct>: Given the context 'We now show that MIP-1 alpha and the related beta chemokine, RANTES, induce transient alterations in intracellular Ca2+ concentration in polymorphonuclear leukocytes that can be reciprocally and specifically desensitized, suggesting a common receptor.', select the correct biomedical conce... | <Mentions>: [mip-1 alpha; beta chemokine; rantes]
<Options>: A: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 (homo sapiens)) (aka c-c motif chemokine ligand 4)
B: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
C: rantes (sus scrofa) (aka c-c motif chemokine ligand 5)
D: c-c motif chemokine ligand ... | [O; F; F] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: ifn-alphaa (homo sapiens) (aka interferon alpha 2)
B: c3xkine (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
C: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
D: il18 (homo sapiens) (aka interleukin 18)
E: groa (homo sapiens) (aka c-x-c motif chemo... | [G; G] |
<Instruct>: Given the context 'It has approximately 33% amino acid identity with receptors for the alpha chemokine, interleukin 8, and may be the human homologue of the product of US28, an open reading frame of human cytomegalovirus.', select the correct biomedical concept for each mention using the provided options. A... | <Mentions>: [alpha chemokine; interleukin 8]
<Options>: A: rantes (xenopus tropicalis) (aka chemokine (c-c motif) ligand 5)
B: c-x-c motif chemokine ligand 8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
C: fgf-8 (homo sapiens) (aka fibroblast growth factor 8)
D: scya8 (homo sapiens) (aka c-c motif chemokine liga... | [B; B] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: p21cip1 (xenopus tropicalis) (aka cyclin-dependent kinase inhibitor 1a)
B: p57kip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 1c)
C: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
D: inhibitor of cdk, cyclin a1 interacting protein 1 (homo s... | [B; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
B: p-cip1 (homo sapiens) (aka ras association domain family member 9)
C: cip2 (homo sapiens) (aka cyclin dependent kinase inhibitor 3)
D: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
... | [I; F] |
<Instruct>: Given the context 'p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [p57kip2; p21cip1]
<Options>: A: kish2 (homo sapiens) (aka chromodomain helicase dna binding protein 9)
B: p27kip1 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
C: inhibitor of cdk, cyclin a1 interacting protein 1 (homo sapiens) (aka inhibitor of cdk, cyclin a1 interacting protein 1)
D: cip2 (ho... | [G; J] |
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