instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [opg]
<Options>: A: opgl (homo sapiens) (aka tnf superfamily member 11)
B: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
C: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b l homeolog (xenopus laevis... | [E] |
<Instruct>: Given the context 'These same effects are observed upon administration of recombinant OPG into normal mice.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
B: opg (homo sapiens) (basic transcription factor 3 pseudogene 11 (homo sapiens)) (aka basic transcription factor 3 pseudogene 11)
C: opg (rattus norvegicus) (aka tnf recepto... | [A] |
<Instruct>: Given the context 'In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: opgg (escherichia coli str. k-12 substr. mg1655) (aka osmoregulated periplasmic glucans biosynthesis protein g)
B: opg (xenopus laevis) (tumor necrosis factor receptor superfamily member 11b l homeolog (xenopus laevis)) (aka tumor necrosis factor receptor superfamily member 11b l homeolo... | [D] |
<Instruct>: Given the context 'Furthermore, OPG blocks ovariectomy-associated bone loss in rats.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [opg]
<Options>: A: rankl (homo sapiens) (aka tnf superfamily member 11)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
C: opgl (rattus norvegicus) (aka tnf superfamily member 11)
D: opg (rattus norvegicus) (aka tnf receptor superfamily m... | [B] |
<Instruct>: Given the context 'These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [opg]
<Options>: A: opg (rattus norvegicus) (aka tnf receptor superfamily member 11b)
B: opg (homo sapiens) (tnf receptor superfamily member 11b (homo sapiens)) (aka tnf receptor superfamily member 11b)
C: opgl (rattus norvegicus) (aka tnf superfamily member 11)
D: opg (xenopus laevis) (tumor necrosis facto... | [B] |
<Instruct>: Given the context 'Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rhohp1]
<Options>: A: rhox homeobox family member 1 (homo sapiens) (aka rhox homeobox family member 1)
B: rhpn1 (homo sapiens) (aka rhophilin rho gtpase binding protein 1)
C: rho1 (drosophila melanogaster) (rhomboid (drosophila melanogaster)) (aka rhomboid)
D: rhohp1 (homo sapiens) (aka ras homolog family ... | [D] |
<Instruct>: Given the context 'Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rhohp1]
<Options>: A: rho1 (drosophila melanogaster) (rhomboid (drosophila melanogaster)) (aka rhomboid)
B: rhox homeobox family member 1 (homo sapiens) (aka rhox homeobox family member 1)
C: rhoh9 (homo sapiens) (aka ras homolog family member c)
D: rhpn1 (homo sapiens) (aka rhophilin rho gtpase binding pr... | [E] |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept for each mention... | <Mentions>: [rhohp1; rho-related protein hp1]
<Options>: A: rhohp1 (homo sapiens) (aka ras homolog family member d)
B: rhobp (homo sapiens) (aka rhophilin rho gtpase binding protein 2)
C: rhoh (homo sapiens) (aka ras homolog family member h)
D: rho-1 (drosophila melanogaster) (aka rhomboid)
E: rho (drosophila melanogas... | [A; A] |
<Instruct>: Given the context 'In view of its degree of homology to members of the Rho family of molecules (50-54% identical amino acids, 60-63% identical nucleotides within the coding region), the predicted product was designated RhoHP1(Rho-related protein HP1).', select the correct biomedical concept for each mention... | <Mentions>: [rhohp1; rho-related protein hp1]
<Options>: A: rho (drosophila melanogaster) (rho1 (drosophila melanogaster)) (aka rho1)
B: rhoh9 (homo sapiens) (aka ras homolog family member c)
C: arhp (homo sapiens) (aka dentin matrix acidic phosphoprotein 1)
D: rho-1 (drosophila melanogaster) (aka rhomboid)
E: rho fami... | [G; G] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: light-regulated protein-like (glycine max) (aka light-regulated protein-like)
B: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer i... | [O; J; S; I] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: v-rel avian reticuloendotheliosis viral oncogene homolog (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog)
B: leucine--trna ligase, cytoplasmic-like (glycine max) (aka leucine--trna ligase, cytoplasmic-like)
C: nf-kb... | [R; N; U; D] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
B: i-kappa-b-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: nuclear fac... | [O; Q; S; L] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
B: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
C: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
D: leucine--trna ... | [R; F; S; O] |
<Instruct>: Given the context 'I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b epsilon; rela; crel; nf-kappa b]
<Options>: A: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: crrl (arabidopsis thaliana) (aka chaperone dnaj-domain superfamily protein)
C: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
D: ikk-e (homo sapiens) (aka inhibitor of nuclear fact... | [D; R; R; A] |
<Instruct>: Given the context 'We have isolated a human cDNA which encodes a novel I kappa B family member using a yeast two-hybrid screen for proteins able to interact with the p52 subunit of the transcription factor NF-kappa B.', select the correct biomedical concept for each mention using the provided options. Answe... | <Mentions>: [nf-kappa b]
<Options>: A: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
D: nfkbib ... | [A] |
<Instruct>: Given the context 'The protein is found in many cell types and its expression is up-regulated following NF-kappa B activation and during myelopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [nf-kappa b]
<Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nf-kappab (homo sapiens) (aka nuclear fact... | [D] |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [i kappa b-epsilon; nf-kappa b]
<Options>: A: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
B: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
C: ikb-ep... | [H; D] |
<Instruct>: Given the context 'Consistent with its proposed role as an I kappa B molecule, I kappa B-epsilon is able to inhibit NF-kappa B-directed transactivation via cytoplasmic retention of rel proteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the select... | <Mentions>: [i kappa b-epsilon; nf-kappa b]
<Options>: A: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
B: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
C: nuclea... | [I; G] |
<Instruct>: Given the context 'I kappa B-epsilon translation initiates from an internal ATG codon to give rise to a protein of 45 kDa, which exists as multiple phosphorylated isoforms in resting cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [i kappa b-epsilon]
<Options>: A: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab kinase epsilon)
B: ikb-epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
C: inhibitor of nuclear factor kappa b kinase subunit epsilon... | [C] |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: crrl (arabidopsis thaliana) (aka chaperone dnaj-domain superfamily protein)
B: crep (homo sapiens) (aka protein phosphatase 1 regulatory subunit 15b)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D: rela proto-o... | [D; K] |
<Instruct>: Given the context 'Unlike the other inhibitors, it is found almost exclusively in complexes containing RelA and/or cRel.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rela; crel]
<Options>: A: creld1 (oryctolagus cuniculus) (aka creld disulfide isomerase 1)
B: creg (homo sapiens) (aka cellular repressor of e1a stimulated genes 1)
C: rel proto-oncogene, nf-kb subunit (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
D: rela (homo sapiens) (aka rela proto-oncogene, n... | [D; K] |
<Instruct>: Given the context 'Upon activation, I kappa B-epsilon protein is degraded with slow kinetics by a proteasome-dependent mechanism.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-epsilon]
<Options>: A: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: nfkbie (homo sapiens) (aka nfkb inhibitor epsilon)
C: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
D: nuclear factor of k... | [A] |
<Instruct>: Given the context 'Similarly to I kappa B-alpha', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b-alpha]
<Options>: A: nfkbib (homo sapiens) (aka nfkb inhibitor beta)
B: nfkbi (homo sapiens) (aka nfkb inhibitor alpha)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta... | [B] |
<Instruct>: Given the context 'and I kappa B, I kappa B-epsilon contains multiple ankyrin repeats and two conserved serines which are necessary for signal-induced degradation of the molecule.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one... | <Mentions>: [i kappa b-epsilon]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells inhibitor, epsilon)
B: ikk-e (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase sub... | [B] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nfkbi (homo sapiens) (aka nfkb inhibitor alpha)
B: ikkb (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit beta)
C: nf-kappa-b1 (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: nfkbib (homo sapiens) (aka nfkb inh... | [G; D; F] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: ikba (homo sapiens) (aka nfkb inhibitor alpha)
B: i-kappa-b-zeta (homo sapiens) (aka nfkb inhibitor zeta)
C: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa l... | [A; G; N] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
B: nfkbi (homo sapiens) (aka nfkb inhibitor alp... | [C; O; L] |
<Instruct>: Given the context 'Unlike I kappa B- alpha and I kappa B-beta, I kappa B-epsilon does not contain a C-terminal PEST-like sequence.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [i kappa b- alpha; i kappa b-beta; i kappa b-epsilon]
<Options>: A: nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon (mus musculus) (aka nuclear factor of kappa light polypeptide gene enhancer in b cells inhibitor, epsilon)
B: nfi-b (homo sapiens) (aka nuclear factor i b... | [M; F; I] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: nuclear factor kappa b subunit 1 (homo sapiens) (aka nuclear facto... | [J; F; U; C] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: cation transport regulator-like protein 2-like (glycine max) (aka cation transport regulator-like protein 2-like)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: rela proto-oncogene, nf-kb subunit (xenopus... | [N; I; S; O] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: inhibitor of nuclear factor kappa b kinase subunit epsilon (homo sapiens) (aka inhibitor of nuclear factor kappa b kinase subunit epsilon)
B: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
... | [A; G; T; C] |
<Instruct>: Given the context 'I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [i kappa b-epsilon; rela; crel; nf-kappa b]
<Options>: A: rela (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
B: probable catabolite repression protein crec (glycine max) (aka probable catabolite repression protein crec)
C: inhibitor of kappab kinase epsilon (mus musculus) (aka inhibitor of kappab ... | [R; A; T; M] |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vps41]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
D: hvps41 (homo sapiens) (aka vps41 subunit of hops complex)
E: vacuolar protein sorti... | [B] |
<Instruct>: Given the context 'Characterization of VPS41, a gene required for vacuolar trafficking and high-affinity iron transport in yeast.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vps41]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
C: hvps41 (homo sapiens) (aka vps41 subunit of hops complex)
D: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans... | [E] |
<Instruct>: Given the context 'Mutations in the yeast gene VPS41 give rise to poor growth on low iron medium, severe alterations in vacuolar morphology, and cause the missorting of membranous and soluble vacuolar proteins.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [vps41]
<Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 4... | [B] |
<Instruct>: Given the context 'Our studies predict that VPS41 encodes a hydrophilic protein of 992 amino acids that contains no obvious signal sequence or hydrophobic domains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [vps41]
<Options>: A: hvps41 (homo sapiens) (aka vps41 subunit of hops complex)
B: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
C: vps41 (drosophila melanogaster) (aka light)
D: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
E: vacuolar protein sorti... | [B] |
<Instruct>: Given the context 'The deduced Vps41p sequence contains a domain rich in glutamic and aspartic residues, as well as a domain with resemblance to a region of clathrin heavy chain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [vps41p]
<Options>: A: vps41 (drosophila melanogaster) (aka light)
B: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
C: atg41p (saccharomyces cerevisiae s288c) (aka atg41p)
D: vps41 (saccharomyces cerevisiae s288c)... | [D] |
<Instruct>: Given the context 'The VPS41 homologues (but not the yeast VPS41 itself) contain a conserved cysteine-rich RING-H2 zinc finger at their COOH termini.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [vps41]
<Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: hvps41p (homo sapiens) (aka vps41 subunit of hops complex)
C: vps41p (saccharomyces cerevisiae s288c) (aka vps41p)
D: vacuolar protein sorting-associated protein 41 homolog (caenorhabdit... | [C] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: vacuolar protein sorting-associated protein 41 homolog (caenorhabditis elegans) (aka vacuolar protein sorting-associated protein 41 homolog)
B: fer3 (drosophila melanogaster) (ferritin 3 heavy chain homologue (drosophila melanogaster)) (aka ferritin 3 heavy chain homologue)
C: v... | [C; G] |
<Instruct>: Given the context 'Biochemical experiments suggest that VPS41 functions in post-Golgi protein processing: the deletion mutant exhibits defective high affinity transport due to impaired Fet3p activity and also exhibits defects in the processing and sorting of multiple vacuolar hydrolases.', select the correc... | <Mentions>: [vps41; fet3p]
<Options>: A: transmembrane protein 41 homolog (caenorhabditis elegans) (aka transmembrane protein 41 homolog)
B: vps41 (drosophila melanogaster) (aka light)
C: vps41 (homo sapiens) (aka vps41 subunit of hops complex)
D: ferry endosomal rab5 effector complex subunit 3 (xenopus tropicalis) (ak... | [H; I] |
<Instruct>: Given the context 'Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated... | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt family member 7a (xenopus tropicalis) (aka wnt family member 7a)
C: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration sit... | [D] |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
C: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
D: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenop... | [C] |
<Instruct>: Given the context 'One mouse member, Wnt7a, is vital for limb development in vivo and also possesses transforming ability in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt7c-a (xenopus laevis) (wingless-type mmtv integration site family, member 7c s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family, member 7c s homeolog)
C: wnt-7a (xenopus laevis) (wingless-typ... | [E] |
<Instruct>: Given the context 'This study reports the isolation of a full length of human homologue of mouse Wnt7a gene by library screening.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt7a (homo sapiens) (aka wnt family member 7a)
B: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus laevis)) (aka wingless-type mmtv integration site family member 7a s homeolog)
C: wnt family member 7a (xenopus tropicalis) (aka wnt fami... | [A] |
<Instruct>: Given the context 'Yeast artificial chromosome-fluorescence in situ hybridisation (YAC-FISH) mapped the WNT7A gene to chromosome 3p25.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [wnt7a]
<Options>: A: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
B: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
C: wnt family member 7a (homo sapiens) (aka wnt family member 7a)
D: wnt-7a (xenopus laevis) (wingless-type mmtv integration site family member 7a s homeolog (xenopus... | [C] |
<Instruct>: Given the context 'Human WNT7A had an ORF encoding a deduced protein of 349 aa that exhibited 97% and 92% identity to mouse Wnt7a at the aa and nucleic acid levels, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [wnt7a]
<Options>: A: wnt family member 7b (homo sapiens) (aka wnt family member 7b)
B: wnt family member 7a (gallus gallus) (aka wnt family member 7a)
C: wnt-7a (homo sapiens) (aka wnt family member 7a)
D: wnt7a (xenopus tropicalis) (aka wnt family member 7a)
E: wnt7c-a (xenopus laevis) (wingless-type mmtv... | [C] |
<Instruct>: Given the context 'The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [smad7]
<Options>: A: smad family member 7 (homo sapiens) (aka smad family member 7)
B: smad7 (mus musculus) (aka smad family member 7)
C: smad family member 5 (mus musculus) (aka smad family member 5)
D: smad7 (drosophila melanogaster) (aka daughters against dpp)
E: smad family member 6 (mus musculus) (aka... | [A] |
<Instruct>: Given the context 'TGFbeta signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separate... | <Mentions>: [smad2]
<Options>: A: smad-2 (mus musculus) (aka smad family member 2)
B: hsmad2 (homo sapiens) (smad family member 2 (homo sapiens)) (aka smad family member 2)
C: smad2 (drosophila melanogaster) (aka smad on x)
D: None of the above. | [B] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad4 (homo sapiens) (aka smad family member 4)
B: hsmad2 (homo sapiens) (smad family member 2 (homo sapiens)) (aka smad family member 2)
C: smad4 (mus musculus) (aka smad family member 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad4 (drosophila mel... | [B; A] |
<Instruct>: Given the context 'This leads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad2; smad4]
<Options>: A: smad2/3 (drosophila melanogaster) (aka smad on x)
B: smad4 (drosophila melanogaster) (aka medea)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: madr2 (homo sapiens) (aka smad family member 2)
E: dpc4 (homo sapiens) (aka smad family member 4)
F: smad f... | [D; E] |
<Instruct>: Given the context 'Here we demonstrate that Smad7 is an inhibitor of TGFbeta signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad7 (drosophila melanogaster) (aka daughters against dpp)
B: smad family member 5 (mus musculus) (aka smad family member 5)
C: smad family member 7 (mus musculus) (aka smad family member 7)
D: smad family member 7 (homo sapiens) (aka smad family member 7)
E: smad family member 6 (mus... | [D] |
<Instruct>: Given the context 'Here we demonstrate that Smad7 is an inhibitor of TGFbeta signaling.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad family member 7 (mus musculus) (aka smad family member 7)
B: smad7 (drosophila melanogaster) (aka daughters against dpp)
C: smad family member 5 (mus musculus) (aka smad family member 5)
D: smad family member 6 (mus musculus) (aka smad family member 6)
E: None of the above. | [E] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad family member 4 (homo sapiens) (aka smad family member 4)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: smad family member 5 (homo sapiens) (aka smad family member 5)
E: smad4 (mus m... | [G; J; A] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
B: mad4 (homo sapiens) (aka max dimerization protein 4)
C: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
D: smad4 (mus musculus) (aka smad famil... | [M; F; L] |
<Instruct>: Given the context 'Smad7 prevents TGFbeta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7; smad2; smad4]
<Options>: A: smad2 (drosophila melanogaster) (aka smad on x)
B: smad family member 4 (xenopus tropicalis) (aka smad family member 4)
C: smad family member 6 (mus musculus) (aka smad family member 6)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: smad family member 5 (mus m... | [I; G; H] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: transforming growth factor, beta receptor i (mus musculus) (aka transforming growth factor, beta receptor i)
B: hsmad2 (homo sapiens) (smad family member 2 (homo sapiens)) (aka smad family member 2)
C: transforming growth factor beta receptor i (xenopus ... | [I; E; B] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: smad6 (homo sapiens) (aka smad family member 6)
B: smad2 (drosophila melanogaster) (aka smad on x)
C: transforming growth factor beta receptor 1 (homo sapiens) (aka transforming growth factor beta receptor 1)
D: smad family member 2 (mus musculus) (aka s... | [G; C; H] |
<Instruct>: Given the context 'Smad7 interacts stably with the activated TGFbeta type I receptor, thereby blocking the association, phosphorylation, and activation of Smad2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [smad7; tgfbeta type i receptor; smad2]
<Options>: A: transforming growth factor, beta receptor i (mus musculus) (aka transforming growth factor, beta receptor i)
B: smad2 (homo sapiens) (aka smad family member 2)
C: transforming growth factor beta receptor i (xenopus tropicalis) (aka transforming growth fa... | [I; L; B] |
<Instruct>: Given the context 'Furthermore, mutations in Smad7 that interfere with receptor binding disrupt its inhibitory activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [smad7]
<Options>: A: smad family member 6 (homo sapiens) (aka smad family member 6)
B: smad (drosophila melanogaster) (mothers against dpp (drosophila melanogaster)) (aka mothers against dpp)
C: smad family member 7 (homo sapiens) (aka smad family member 7)
D: smad family member 5 (mus musculus) (aka smad ... | [C] |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox28 (homo sapiens) (aka sry-box transcription factor 14)
B: sox21 (homo sapiens) (aka sry-box transcription factor 21)
C: sox22 (homo sapiens) (aka sry-box transcription factor 12)
D: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
E: sox2.s (xeno... | [C] |
<Instruct>: Given the context 'SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox21 (homo sapiens) (aka sry-box transcription factor 21)
B: sox28 (homo sapiens) (aka sry-box transcription factor 14)
C: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
D: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-b... | [E] |
<Instruct>: Given the context 'SOX (SRY box-containing) genes share a particular DNA-binding domain, called HMG, with the mammalian testis-determining gene SRY Several SOX genes have already been shown to be transcription factors involved in the decision of important cell fates during development.', select the correct ... | <Mentions>: [sry]
<Options>: A: sry (homo sapiens) (aka sex determining region y)
B: sex-determining region y protein (sus scrofa) (aka sex-determining region y protein)
C: sry-a (drosophila melanogaster) (aka serendipity alpha)
D: sry (drosophila melanogaster) (sprouty (drosophila melanogaster)) (aka sprouty)
E: sex d... | [A] |
<Instruct>: Given the context 'Here we report the cloning of a new human member of the SOX gene family, SOX22.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sox22]
<Options>: A: sox22 (homo sapiens) (aka sry-box transcription factor 12)
B: sox20 (homo sapiens) (aka sry-box transcription factor 15)
C: sox28 (homo sapiens) (aka sry-box transcription factor 14)
D: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
E: sox2.s (xeno... | [A] |
<Instruct>: Given the context 'The SOX22 gene maps to chromosome 20 on band p13 and does not appear to be clustered with any other SOX gene mapped to date.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [sox22]
<Options>: A: sox2.s (xenopus laevis) (sry-box 2 s homeolog (xenopus laevis)) (aka sry-box 2 s homeolog)
B: sox28 (homo sapiens) (aka sry-box transcription factor 14)
C: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox-2-like)
D: sox2 (homo sapiens) (aka sry-box transcrip... | [E] |
<Instruct>: Given the context 'SOX22 mRNA is expressed in various fetal and adult organs and tissues, suggesting that this gene plays roles in both differentiation and maintenance of several cell types.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected o... | <Mentions>: [sox22]
<Options>: A: sry-box transcription factor 2 (homo sapiens) (aka sry-box transcription factor 2)
B: sox22 (homo sapiens) (aka sry-box transcription factor 12)
C: sox27 (homo sapiens) (aka sry-box transcription factor 15)
D: transcription factor sox-2-like (homo sapiens) (aka transcription factor sox... | [B] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
B: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
C: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
D: retinal de... | [D; D] |
<Instruct>: Given the context 'A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: rdgb2 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 2)
B: primary retinal dysplasia (homo sapiens) (aka primary retinal dysplasia)
C: retinal degeneration c (drosophila melanogaster) (aka retinal degeneration c)
D: rdgb1 (homo sapi... | [C; C] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: rdgb1 (homo sapiens) (aka phosphatidylinositol transfer protein membrane associated 1)
B: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
C: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
D: r... | [E; E] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: retinal degeneration a (drosophila melanogaster) (aka retinal degeneration a)
B: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka retinal pigment epithelium-derived rhodopsin homolog)
C: retinal degeneration g (drosophila melanogaste... | [H; H] |
<Instruct>: Given the context 'Through our transcriptional mapping effort in the Xp22 region, we have isolated by exon trapping a new transcript highly homologous to the Drosophila retinal degeneration C (rdgC) gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing ... | <Mentions>: [retinal degeneration c; rdgc]
<Options>: A: rdgca (homo sapiens) (aka integral membrane protein 2b)
B: retinal degeneration e (drosophila melanogaster) (aka retinal degeneration e)
C: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
D: rdgb1 (homo sapiens) (aka phosph... | [F; F] |
<Instruct>: Given the context 'rdgC encodes a serine/threonine phosphatase protein and is required in Drosophila to prevent light-induced retinal degeneration.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by ... | <Mentions>: [rdgc]
<Options>: A: rdgc (drosophila melanogaster) (aka retinal degeneration c)
B: rd3 (homo sapiens) (aka rd3 regulator of gucy2d)
C: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
D: retinal pigment epithelium-derived rhodopsin homolog (xenopus tropicalis) (aka re... | [A] |
<Instruct>: Given the context 'This human gene is the first mammalian member of the serine-threonine phosphatase with EF hand motif gene family, and was thus named PPEF (Protein Phosphatase with EF calcium-binding domain).', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [ppef]
<Options>: A: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
B: pedf (homo sapiens) (aka serpin family f member 1)
C: ppef1 (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
D: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 1)
E:... | [C] |
<Instruct>: Given the context 'The expression pattern of the mouse Ppef gene was studied by RNA in situ hybridization on embryonic tissue sections.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ppef]
<Options>: A: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 1)
B: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
C: pedf (homo sapiens) (aka serpin family f member 1)
D: ppef2 (homo sapiens) (aka protein phosphatase with ef... | [E] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: rdgc (drosophila melanogaster) (aka retinal degeneration c)
B: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
C: rdgc (escherichia coli str. k-12 substr. mg1655) (aka nucleoid-associated protein rdgc)
D: epf (homo sapiens) (aka heat shock pro... | [A; B] |
<Instruct>: Given the context 'While rdgC is expressed in the visual system of the fly, as well as in the mushroom bodies of the central brain, we found that Ppef is highly expressed in sensory neurons of the dorsal root ganglia (DRG) and neural crest-derived cranial ganglia.', select the correct biomedical concept for... | <Mentions>: [rdgc; ppef]
<Options>: A: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
B: retinal degeneration g (drosophila melanogaster) (aka retinal degeneration g)
C: ppef (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
D: ppef1 (xenopus tropicalis) (aka protein phosphatase, ef-... | [I; H] |
<Instruct>: Given the context 'The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [ppef]
<Options>: A: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
B: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
C: ppef (homo sapiens) (aka protein phosphatase with ef-hand domain 1)
D: ppef2 (homo sapiens) (aka protein pho... | [C] |
<Instruct>: Given the context 'The selective pattern of expression makes PPEF an important marker for sensory neuron differentiation and suggests a role for serine-threonine phosphatases in mammalian development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the ... | <Mentions>: [ppef]
<Options>: A: ppef-1 (mus musculus) (aka protein phosphatase with ef hand calcium-binding domain 1)
B: ppef2 (xenopus tropicalis) (aka protein phosphatase, ef-hand calcium binding domain 2)
C: ppef2 (homo sapiens) (aka protein phosphatase with ef-hand domain 2)
D: ppef1 (bos taurus) (aka protein phos... | [E] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: hgh1 (homo sapiens) (aka hgh1 cochaperone)
B: hhg1 (homo sapiens) (aka sonic hedgehog signaling molecule)
C: hogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
E: hspg1 (homo sapiens) ... | [C; I] |
<Instruct>: Given the context 'Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hogg1; ogg1]
<Options>: A: hoga1 (homo sapiens) (aka 4-hydroxy-2-oxoglutarate aldolase 1)
B: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
C: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: ogs1 (homo sapiens) (aka midline 1)
E: hgh1 (homo sapiens) (aka h... | [C; K] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: fpg (escherichia coli str. k-12 substr. mg1655) (aka dna-formamidopyrimidine glycosylase)
B: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: fpg1 (homo sapiens) (aka nei like dna glycosylase 1)
D: fpg-1 (arabidopsis thaliana) (aka mutm homolog-1)
E: ogh1 (homo ... | [K; A] |
<Instruct>: Given the context 'The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase activity that is a functional analog of the Fpg protein from Escherichia coli and excises 7,8-dihydro-8-oxoguanine (8-oxoG) from damaged DNA.', select the correct biomedical concept for each mention using the provided opt... | <Mentions>: [ogg1; fpg]
<Options>: A: fpg1 (homo sapiens) (aka nei like dna glycosylase 1)
B: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
C: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
D: fpgt (xenopus tropicalis) (aka fucose-1-phosphate guanylyltransferase)
E: fp... | [K; J] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: endo-i (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
B: endonuclease iii (escherichia coli str. k-12 substr. mg1655) (aka endonuclease iii)
C: endonuclease v (xenopus tropicalis) (aka endonuclease v)
D: n-gl... | [K; B] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: endonuclease v (rattus norvegicus) (aka endonuclease v)
C: ogs1 (homo sapiens) (aka midline 1)
D: endo-i (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacteri... | [J; J] |
<Instruct>: Given the context 'This protein shares a 38% sequence identity with the yeast Ogg1 protein, adding this novel human gene product to the growing family of enzymes that the repair of oxidatively damaged bases and are related to the E. coli endonuclease III.', select the correct biomedical concept for each men... | <Mentions>: [ogg1; endonuclease iii]
<Options>: A: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
C: endo-i (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
D: ... | [K; D] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: fpg (escherichia coli str. k-12 substr. mg1655) (aka dna-formamidopyrimidine glycosylase)
B: ogh1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: fpgt (xenopus laevis) (aka fucose-1-phosphate guanylyltransferase l homeolog)
D: fpg2 (homo sapiens) (aka nei like dna glycosylase ... | [A; K] |
<Instruct>: Given the context 'The cloned coding sequence was expressed in an E. coli strain that carried a disrupted fpg gene, the bacterial functional analog of OGG1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sepa... | <Mentions>: [fpg; ogg1]
<Options>: A: fpg (escherichia coli str. k-12 substr. mg1655) (aka dna-formamidopyrimidine glycosylase)
B: ogs1 (homo sapiens) (aka midline 1)
C: fpgt (homo sapiens) (aka fucose-1-phosphate guanylyltransferase)
D: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
E: ... | [A; K] |
<Instruct>: Given the context 'The products of the reaction are consistent with an enzymatic activity like the one displayed by the yeast Ogg1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ogg1]
<Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine dna glycosylase)
D: ogs1 (homo sapiens) (aka midline 1)
E: ogg1 (mus musculus) (aka 8-oxo... | [F] |
<Instruct>: Given the context 'Moreover, when the human coding sequence was expressed in a yeast strain mutant in OGG1 it was able to complement the spontaneous mutator phenotype.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each me... | <Mentions>: [ogg1]
<Options>: A: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
B: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
C: ogs1 (homo sapiens) (aka midline 1)
D: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
E: ogg1 (oryctolagu... | [F] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: hgh1 (homo sapiens) (aka hgh1 cochaperone)
C: ogs1 (homo sapiens) (aka midline 1)
D: ogg1 (drosophila melanogaster) (aka 8-oxoguanine dna glycosylase)
E: ogg1 (mus musculus) (aka 8-oxoguanine dna-glycosylase 1)
F: homg1 (h... | [G; J] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: ogg1 (homo sapiens) (aka 8-oxoguanine dna glycosylase)
B: ogs1 (homo sapiens) (aka midline 1)
C: hspg1 (homo sapiens) (aka syndecan 2)
D: homg1 (homo sapiens) (aka transient receptor potential cation channel subfamily m member 6)
E: n-glycosylase/dna lyase ogg1 (glycine max) (aka... | [I; I] |
<Instruct>: Given the context 'These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the protection of the genome from the mutagenic effects of the oxidatively damaged purines.', select the correct biomedical concept for eac... | <Mentions>: [hogg1; ogg1]
<Options>: A: n-glycosylase/dna lyase ogg1 (glycine max) (aka n-glycosylase/dna lyase ogg1)
B: hgh1 (homo sapiens) (aka hgh1 cochaperone)
C: 8-oxoguanine dna glycosylase (homo sapiens) (aka 8-oxoguanine dna glycosylase)
D: 8-oxoguanine dna glycosylase (oryctolagus cuniculus) (aka 8-oxoguanine ... | [C; K] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: kcnrg (homo sapiens) (aka potassium channel regulator)
B: herg2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
C: minp (homo sapiens) (aka bmerb domain containing 1)
D: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1... | [D; I] |
<Instruct>: Given the context 'A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.', select the correct biomedical concept for each mention using the ... | <Mentions>: [mink; herg]
<Options>: A: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, member 1)
B: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
C: girk1 (homo sapiens) (aka potassium inw... | [H; G] |
<Instruct>: Given the context 'MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [mink]
<Options>: A: mink1 (mus musculus) (aka misshapen-like kinase 1 (zebrafish))
B: minp (homo sapiens) (aka bmerb domain containing 1)
C: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka potassium voltage-gated channel, isk-related subfamily, mem... | [D] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: kvlqt1 (sus scrofa) (aka potassium voltage-gated channel subfamily q member 1)
B: mink1 (homo sapiens) (aka misshapen like kinase 1)
C: min (mus musculus) (aka apc, wnt signaling pathway regulator)
D: kvlqt1-as (homo sapiens) (aka kcnq1 opposite strand/antisense transcript 1)
E:... | [H; G] |
<Instruct>: Given the context 'Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the slow cardiac repolarization current (I[Ks]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [mink; kvlqt1]
<Options>: A: min (mus musculus) (aka apc, wnt signaling pathway regulator)
B: mina (mus musculus) (aka ribosomal oxygenase 2)
C: kvlqt1 (xenopus laevis) (potassium channel, voltage gated kqt-like subfamily q, member 1 l homeolog (xenopus laevis)) (aka potassium channel, voltage gated kqt-lik... | [E; F] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
B: herg1 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
C: goe (drosophila melanogaster) (aka gone early)
D: kcnrg (homo sapiens) (aka potassium channel regu... | [B; H] |
<Instruct>: Given the context 'HERG, a human homologue of the ether-a-go-go gene of the fruitfly Drosophila melanogaster, encodes a protein that produces the rapidly activating cardiac delayed rectifier (I[Kr]).', select the correct biomedical concept for each mention using the provided options. Answer by listing the s... | <Mentions>: [herg; ether-a-go-go]
<Options>: A: go (drosophila melanogaster) (glucose dehydrogenase (drosophila melanogaster)) (aka glucose dehydrogenase)
B: go-alpha (drosophila melanogaster) (aka g protein alpha subunit o)
C: herg-2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
D: kcng (ho... | [G; J] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: girk1 (homo sapiens) (aka potassium inwardly rectifying channel subfamily j member 3)
C: herg (homo sapie... | [C; A] |
<Instruct>: Given the context 'Although heterologously expressed HERG channels are largely indistinguishable from native cardiac I(Kr), a role for minK in this current is suggested by the diminished I(Kr) in an atrial tumour line subjected to minK antisense suppression.', select the correct biomedical concept for each ... | <Mentions>: [herg; mink]
<Options>: A: kcng (homo sapiens) (aka potassium voltage-gated channel modifier subfamily g member 1)
B: herg (homo sapiens) (aka potassium voltage-gated channel subfamily h member 2)
C: herg2 (homo sapiens) (aka potassium voltage-gated channel subfamily h member 6)
D: girk1 (homo sapiens) (aka... | [B; G] |
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