instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
B: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
C: kcnrg (homo sapiens) (aka pot... | [I; B] |
<Instruct>: Given the context 'Here we show that HERG and minK form a stable complex, and that this heteromultimerization regulates I(Kr) activity.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [herg; mink]
<Options>: A: kcnrg (homo sapiens) (aka potassium channel regulator)
B: mink (drosophila melanogaster) (aka mitotic spindle and nuclear protein)
C: h-eag (homo sapiens) (aka potassium voltage-gated channel subfamily h member 1)
D: mink (homo sapiens) (potassium voltage-gated channel subfamily e... | [I; D] |
<Instruct>: Given the context 'MinK, through the formation of heteromeric channel complexes, is thus central to the control of the heart rate and rhythm.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semico... | <Mentions>: [mink]
<Options>: A: mink (homo sapiens) (potassium voltage-gated channel subfamily e regulatory subunit 1 (homo sapiens)) (aka potassium voltage-gated channel subfamily e regulatory subunit 1)
B: mink (mus musculus) (potassium voltage-gated channel, isk-related subfamily, member 1 (mus musculus)) (aka pota... | [A] |
<Instruct>: Given the context 'X-linked IAP is a direct inhibitor of cell-death proteases.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [x-linked iap]
<Options>: A: x-linked inhibitor of apoptosis (homo sapiens) (aka x-linked inhibitor of apoptosis)
B: iap-1 (homo sapiens) (aka baculoviral iap repeat containing 3)
C: ml-iap (xenopus laevis) (baculoviral iap repeat containing 7 l homeolog (xenopus laevis)) (aka baculoviral iap repeat contain... | [A] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: c-iap1 (xenopus laevis) (baculoviral iap repeat containing 2 s homeolog (xenopus laevis)) (aka baculoviral iap repeat containing 2 s homeolog)
B: caspase-3 (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
C: casp-... | [M; K; I] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: casp8 (homo sapiens) (aka caspase 8)
B: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
C: ml-iap (xenopus laevis) (baculoviral iap repeat containing 7 s homeolog... | [G; E; O] |
<Instruct>: Given the context 'Here we show that human X-chromosome-linked IAP directly inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [x-chromosome-linked iap; caspase-3; caspase-7]
<Options>: A: casp5 (homo sapiens) (aka caspase 5)
B: casp3 (homo sapiens) (aka caspase 3)
C: caspase 7 (homo sapiens) (aka caspase 7)
D: x-linked inhibitor of apoptosis (homo sapiens) (aka x-linked inhibitor of apoptosis)
E: ciap1 (xenopus laevis) (baculovira... | [D; F; C] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanogaster)) (aka fragile x messenger ribonucleoprotein 1)
B: fxr1p (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fmr1 ... | [N; M; J] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 1 (xenopus tropicalis) (xtfxr1p-a (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
B: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homolog 1)
C: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
D: fmr1 autosomal... | [M; G; J] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr1-a (xenopus laevis) (fmr1 autosomal homolog 1 l homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 l homeolog)
B: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
C: fxr (xenopus tropicalis) (aka nuclear rece... | [L; J; L] |
<Instruct>: Given the context 'Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
B: fxr1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fxr (drosophila melanogaster) (fizzy-related (drosophila melanogaster)) (aka fizzy-related)
D: nr1f2 (homo sapiens) (aka rar related orphan r... | [O; B; F] |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [fragile x mental retardation protein; fmrp]
<Options>: A: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
B: fmr1 (homo sapiens) (fragile x messenger ribonucleoprotein 1 (homo sapiens)) (aka fragile x messenger ribonucleoprotein 1)
C: fragile x messenger ribonucleoprotein 1 (drosophi... | [B; B] |
<Instruct>: Given the context 'Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients.', select the correct biomedical concept for each mention using the provided options. Answer by listing the... | <Mentions>: [fragile x mental retardation protein; fmrp]
<Options>: A: fmrp (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
B: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 (homo sapiens) (fragile site, folic acid type, rare, fra(x)(q27.3) a (homo sapiens)) (aka fragi... | [E; E] |
<Instruct>: Given the context 'FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp]
<Options>: A: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
B: fxr (drosophila melanogaster) (fragile x messenger ribonucleoprotein 1 (drosophila melanogaster)) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (mus musculus) (aka fmr1 autosomal homol... | [D] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fxr (drosophila melanogaster) (fizzy-related (drosophila melanogaster)) (aka fizzy-related)
B: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fxr1 (xenopus tropicalis) (aka fmr1 autosomal homolog 1)... | [J; I; F] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fmrp (drosophila melanogaster) (aka fragile x messenger ribonucleoprotein 1)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
D: fxr1-a (xenopus laevis) (fmr1 autosomal h... | [L; J; A] |
<Instruct>: Given the context 'Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmrp; fxr1; fxr2]
<Options>: A: fmrp (xenopus tropicalis) (aka fragile x messenger ribonucleoprotein 1)
B: fxr1-b (xenopus laevis) (fmr1 autosomal homolog 1 s homeolog (xenopus laevis)) (aka fmr1 autosomal homolog 1 s homeolog)
C: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)... | [M; G; J] |
<Instruct>: Given the context 'These novel proteins interact with FMRP and with each other and they are also associated with the 60S ribosomal subunit.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolo... | <Mentions>: [fmrp]
<Options>: A: fmrp (mus musculus) (aka fragile x messenger ribonucleoprotein 1)
B: fmrp (homo sapiens) (aka fragile x messenger ribonucleoprotein 1)
C: fmr1 autosomal homolog 1 (homo sapiens) (aka fmr1 autosomal homolog 1)
D: fragile x messenger ribonucleoprotein 1 (drosophila melanogaster) (aka frag... | [B] |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 (homo sapiens) (fragile site, folic acid type, rare, fra(x)(q27.3) a (homo sapiens)) (aka fragile site, folic acid type, rare, fra(x)(q27.3) a)
B: fxr (xenopus tropicalis) (aka nuclear receptor subfamily 1 group h member 4)
C: fxr1-b (xenopus tropicalis) (aka fmr1 autos... | [P; F; L] |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fxr1 (xenopus tropicalis) (aka fmr1 autosomal homolog 1)
B: fxr1 (homo sapiens) (aka fmr1 autosomal homolog 1)
C: fxr (drosophila melanogaster) (fizzy-related (drosophila melanogaster)) (aka fizzy-related)
D: fxr2 (homo sapiens) (aka fmr1 autosomal homolog 2)
E: fxr1p (xenop... | [N; B; D] |
<Instruct>: Given the context 'In adult brain, FMR1, FXR1 and FXR2 proteins are coexpressed in the cytoplasm of specific differentiated neurons only.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fmr1; fxr1; fxr2]
<Options>: A: fmr1 autosomal homolog 2 (homo sapiens) (aka fmr1 autosomal homolog 2)
B: fmr1 autosomal homolog 1 (xenopus tropicalis) (frx1l (xenopus tropicalis)) (aka fmr1 autosomal homolog 1)
C: fxr (homo sapiens) (aka nuclear receptor subfamily 1 group h member 4)
D: fmr1 autosomal hom... | [N; J; A] |
<Instruct>: Given the context 'PHOG, a candidate gene for involvement in the short stature of Turner syndrome.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog]
<Options>: A: phog1 (homo sapiens) (aka shox homeobox)
B: pp2cg (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1g)
C: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
D: pho88 (saccharomyces cerevisiae s288c) (aka snd3p)
E: hptpg (homo ... | [A] |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog; pseudoautosomal homeobox-containing osteogenic gene]
<Options>: A: phosphoglycolate phosphatase (homo sapiens) (aka phosphoglycolate phosphatase)
B: sulfite oxidase pseudogene (homo sapiens) (aka sulfite oxidase pseudogene)
C: osteoglycin s homeolog (xenopus laevis) (aka osteoglycin s homeolog)
D: me... | [E; E] |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog; pseudoautosomal homeobox-containing osteogenic gene]
<Options>: A: pho88 (saccharomyces cerevisiae s288c) (aka snd3p)
B: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
C: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcripti... | [I; I] |
<Instruct>: Given the context 'We have named the gene PHOG, for pseudoautosomal homeobox-containing osteogenic gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [phog; pseudoautosomal homeobox-containing osteogenic gene]
<Options>: A: hptpg (homo sapiens) (aka protein tyrosine phosphatase receptor type g)
B: ooep-as (homo sapiens) (aka ooep antisense rna 1)
C: meiotic recombination hotspot shox (homo sapiens) (aka meiotic recombination hotspot shox)
D: shox homeobo... | [I; I] |
<Instruct>: Given the context 'Its deletion in patients with short stature, the predicted altered dosage in 45,X individuals, along with the nature of the encoded protein and its expression pattern, make PHOG an attractive candidate for involvement in the short stature of Turner syndrome.', select the correct biomedica... | <Mentions>: [phog]
<Options>: A: phog1 (homo sapiens) (aka shox homeobox)
B: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
C: hptpg (homo sapiens) (aka protein tyrosine phosphatase receptor type g)
D: pho88 (saccharomyces cerevisiae s288c) (aka snd3p)
E: pho9 (sacch... | [A] |
<Instruct>: Given the context 'We have also found that the mouse homolog of PHOG is autosomal, which may help to explain the lack of a growth abnormality in mice with monosomy X.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [phog]
<Options>: A: phop (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator phop)
B: pho85 (saccharomyces cerevisiae s288c) (aka cyclin-dependent serine/threonine-protein kinase pho85)
C: pho88 (saccharomyces cerevisiae s288c) (aka snd3p)
D: pho9 (saccharomyces cere... | [E] |
<Instruct>: Given the context 'cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 4 (xenopus tropicalis) (aka signal transducer and activator of transcription 4)
B: stat4 (homo sapiens) (aka signal transducer and activator of transcription 4)
C: stat4 (bos taurus) (aka signal transducer and activator of transcr... | [B; G] |
<Instruct>: Given the context 'cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated b... | <Mentions>: [stat4; stat1]
<Options>: A: stat1 (homo sapiens) (aka signal transducer and activator of transcription 1)
B: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
C: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transc... | [G; A] |
<Instruct>: Given the context 'STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is essential for IL-12 signal transduction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4]
<Options>: A: stati4 (homo sapiens) (aka suppressor of cytokine signaling 6)
B: signal transducer and activator of transcription 4 (xenopus tropicalis) (aka signal transducer and activator of transcription 4)
C: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
D: st... | [D] |
<Instruct>: Given the context 'The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2-->q32.3 by fluorescence in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 4 (xenopus tropicalis) (aka signal transducer and activator of transcription 4)
B: stat91 (homo sapiens) (aka signal transducer and activator of transcription 1)
C: stat3 (homo sapiens) (aka signal transducer and activator of tran... | [E; B] |
<Instruct>: Given the context 'The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2-->q32.3 by fluorescence in situ hybridization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ... | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transcription 4)
B: signal transducer and activator of transcription 5a (homo sapiens) (aka signal transducer and activator of transcription 5a)
C: il-4-statb (homo sapiens)... | [A; G] |
<Instruct>: Given the context 'These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4; stat1]
<Options>: A: signal transducer and activator of transcription 5a (homo sapiens) (aka signal transducer and activator of transcription 5a)
B: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transcription 4)
C: signal transducer and act... | [G; F] |
<Instruct>: Given the context 'These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [stat4; stat1]
<Options>: A: isgf-3 (homo sapiens) (signal transducer and activator of transcription 1 (homo sapiens)) (aka signal transducer and activator of transcription 1)
B: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transcription 4)
C: sta... | [J; A] |
<Instruct>: Given the context 'However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [stat1; stat4]
<Options>: A: il-4-statb (homo sapiens) (aka signal transducer and activator of transcription 6)
B: stat2 (homo sapiens) (aka signal transducer and activator of transcription 2)
C: signal transducer and activator of transcription 4 (homo sapiens) (aka signal transducer and activator of transc... | [D; C] |
<Instruct>: Given the context 'However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected optio... | <Mentions>: [stat1; stat4]
<Options>: A: signal transducer and activator of transcription 5a (homo sapiens) (aka signal transducer and activator of transcription 5a)
B: signal transducer and activator of transcription 4 (xenopus tropicalis) (aka signal transducer and activator of transcription 4)
C: stat91 (homo sapien... | [C; G] |
<Instruct>: Given the context 'Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, sep... | <Mentions>: [rab7l1]
<Options>: A: rab7l (xenopus laevis) (aka rab29, member ras oncogene family s homeolog)
B: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
C: rab7l1 (homo sapiens) (aka rab29, member ras oncogene family)
D: rab... | [C] |
<Instruct>: Given the context 'A full-length cDNA homologous to RAB7, a member of the RAB-related GTP-binding protein subfamily, was isolated from a human placenta cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each ment... | <Mentions>: [rab7]
<Options>: A: rab7 (homo sapiens) (rab7a, member ras oncogene family (homo sapiens)) (aka rab7a, member ras oncogene family)
B: rab7 (xenopus laevis) (rab7a, member ras oncogene family l homeolog (xenopus laevis)) (aka rab7a, member ras oncogene family l homeolog)
C: rab7b (homo sapiens) (aka rab7b, ... | [A] |
<Instruct>: Given the context 'This cDNA, designated RAB7L1, has an open reading frame of 609 nucleotides encoding 203 amino acids.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rab7l1]
<Options>: A: rab7b, member ras oncogene family l homeolog (xenopus laevis) (aka rab7b, member ras oncogene family l homeolog)
B: rab7l1 (homo sapiens) (aka rab29, member ras oncogene family)
C: rab7l1 (drosophila melanogaster) (aka rab32)
D: rab7, member ras oncogene family-like 1 (gallus gallus) ... | [B] |
<Instruct>: Given the context 'In this work we provide a novel approach to this problem using a beta-arrestin2/green fluorescent protein conjugate (betaarr2-GFP).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [beta-arrestin2; betaarr2]
<Options>: A: arrestin beta 1 (homo sapiens) (aka arrestin beta 1)
B: arrestin 2 (drosophila melanogaster) (aka arrestin 2)
C: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
D: adrb2r (homo sapiens) (aka adrenoceptor beta 2)
E: arrestin beta 2 (bos taurus) (aka arrestin beta ... | [F; F] |
<Instruct>: Given the context 'In this work we provide a novel approach to this problem using a beta-arrestin2/green fluorescent protein conjugate (betaarr2-GFP).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated ... | <Mentions>: [beta-arrestin2; betaarr2]
<Options>: A: grin2b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 2b)
B: arr2 (homo sapiens) (aka arrestin beta 2)
C: arrestin domain containing 2 (homo sapiens) (aka arrestin domain containing 2)
D: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
E: arb... | [B; B] |
<Instruct>: Given the context 'Confocal microscopy demonstrates the translocation of betaarr2-GFP to more than 15 different ligand-activated GPCRs.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [betaarr2]
<Options>: A: arrb2 (rattus norvegicus) (arrestin, beta 2, pseudogene (rattus norvegicus)) (aka arrestin, beta 2, pseudogene)
B: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
C: grin2b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 2b)
D: adrb2r (homo sapiens) (aka adre... | [E] |
<Instruct>: Given the context 'The use of betaarr2-GFP as a biosensor to recognize the activation of pharmacologically distinct GPCRs should accelerate the identification of orphan receptors and permit the optical study of their signal transduction biology intractable to ordinary biochemical methods.', select the corre... | <Mentions>: [betaarr2]
<Options>: A: arr2 (homo sapiens) (aka arrestin beta 2)
B: adrb2r (homo sapiens) (aka adrenoceptor beta 2)
C: grin2b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 2b)
D: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
E: arrb2 (rattus norvegicus) (arrestin, beta 2, pseud... | [A] |
<Instruct>: Given the context 'The use of betaarr2-GFP as a biosensor to recognize the activation of pharmacologically distinct GPCRs should accelerate the identification of orphan receptors and permit the optical study of their signal transduction biology intractable to ordinary biochemical methods.', select the corre... | <Mentions>: [betaarr2]
<Options>: A: arrb2 (rattus norvegicus) (arrestin, beta 2, pseudogene (rattus norvegicus)) (aka arrestin, beta 2, pseudogene)
B: grin2b (homo sapiens) (aka glutamate ionotropic receptor nmda type subunit 2b)
C: betaarr2 (xenopus tropicalis) (aka arrestin beta 2)
D: adrb2r (homo sapiens) (aka adre... | [E] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: tissue factor pathway inhibitor 2 (homo sapiens) (aka tissue factor pathway inhibitor 2)
B: hgf (homo sapiens) (hepatocyte growth factor (homo sapiens)) (aka hepatocyte growth factor)
C: serine... | [M; K; D] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: hai-2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
B: hgf2 (homo sapiens) (aka gingival fibromatosis, hereditary, 2)
C: serpina2 (homo sapiens) (aka serpin family a member 2 (... | [A; M; F] |
<Instruct>: Given the context 'Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.
Hepatocyte growth factor (HGF) activator is a serine protease responsible for proteolytic activation of HGF in response to tissue injury and thus plays an important ro... | <Mentions>: [hepatocyte growth factor activator inhibitor type 2; hepatocyte growth factor (hgf) activator; hgf]
<Options>: A: hepatocyte growth factor (homo sapiens) (aka hepatocyte growth factor)
B: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
C: hgf activator (xenopus tropicalis) (aka hgf ac... | [L; G; A] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: hgfl (homo sapiens) (macrophage stimulating 1 (homo sapiens)) (aka macrophage stimulating 1)
B: protein inhibitor of activated stat 1 (homo sapiens) (aka protein inhibitor of activated stat 1)
C: haip1 (homo sapiens) (aka baculoviral iap r... | [M; G; G] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: hgf activator (rattus norvegicus) (aka hgf activator)
B: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
C: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
D: hgfac (homo sapiens) (aka hgf activator)
E: hait1 (homo s... | [D; I; I] |
<Instruct>: Given the context 'We previously purified an inhibitor of HGF activator (HGF activator inhibitor type 1, HAI-1) from the conditioned medium of a human stomach carcinoma cell line MKN45 and cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing... | <Mentions>: [hgf activator; hgf activator inhibitor type 1; hai-1]
<Options>: A: hai1 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 1)
B: hai2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
C: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
D: hait1 (homo sapiens) (aka solute carri... | [L; A; A] |
<Instruct>: Given the context 'HAI-1 is a novel member of the Kunitz family of serine protease inhibitors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hai-1]
<Options>: A: hait1 (homo sapiens) (aka solute carrier family 71 member 1)
B: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
C: haik1 (homo sapiens) (aka keratin 23)
D: hai (homo sapiens) (serine peptidase inhibitor, kunitz type 1 (homo sapiens)) (aka serine peptidase inhibitor, kuni... | [D] |
<Instruct>: Given the context 'In the present study, we purified a second type of HGF activator inhibitor (HAI-2) from the conditioned medium of MKN45 cells and molecularly cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [hgf activator; hai-2]
<Options>: A: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
B: serine peptidase inhibitor, kunitz type 2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
C: iti-hc2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
D: hgfl (homo sapiens) (m... | [I; B] |
<Instruct>: Given the context 'In the present study, we purified a second type of HGF activator inhibitor (HAI-2) from the conditioned medium of MKN45 cells and molecularly cloned its cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one f... | <Mentions>: [hgf activator; hai-2]
<Options>: A: serine peptidase inhibitor, kunitz type 2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
B: hepatocyte growth factor activator (mus musculus) (aka hepatocyte growth factor activator)
C: serpinf2 (homo sapiens) (aka serpin family f member 2)
D: hgf (homo s... | [H; A] |
<Instruct>: Given the context 'The cDNA sequence revealed that HAI-2 is derived from a precursor protein of 252 amino acids and contains two Kunitz domains, indicating that HAI-2 is also a member of the Kunitz family of serine protease inhibitors.', select the correct biomedical concept for each mention using the provi... | <Mentions>: [hai-2]
<Options>: A: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
B: inter-alpha-trypsin inhibitor heavy chain 2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
C: hai-2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
D: tfpi-2 (homo sapiens) (aka tissue fac... | [C] |
<Instruct>: Given the context 'The primary translation product of HAI-2 has a hydrophobic sequence in the COOH-terminal region, suggesting that, like HAI-1, HAI-2 is produced in a membrane-associated form and secreted in a proteolytically truncated form.', select the correct biomedical concept for each mention using th... | <Mentions>: [hai-2; hai-1]
<Options>: A: hai-1 (sus scrofa) (aka serine peptidase inhibitor, kunitz type 1)
B: hai1 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 1)
C: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
D: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member ... | [H; B] |
<Instruct>: Given the context 'The primary translation product of HAI-2 has a hydrophobic sequence in the COOH-terminal region, suggesting that, like HAI-1, HAI-2 is produced in a membrane-associated form and secreted in a proteolytically truncated form.', select the correct biomedical concept for each mention using th... | <Mentions>: [hai-2; hai-1]
<Options>: A: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
B: tfpi-2 (homo sapiens) (aka tissue factor pathway inhibitor 2)
C: hai2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
D: hai-1 (sus scrofa) (aka serine peptidase inhibitor, kunitz type 1)
E: hai1 (ho... | [C; E] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1)
B: inter-alpha-trypsin inhibitor heavy chain 2 (homo sapiens) (aka inter-alpha-trypsin inhibitor heavy chain 2)
C: hai-2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
... | [C; K; S; F] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hepatocyte growth factor (homo sapiens) (aka hepatocyte growth factor)
B: hcinf2 (homo sapiens) (aka solute carrier family 34 member 1)
C: hai2 (homo sapiens) (aka serine peptidase inhibitor, kunitz type 2)
D: hgf activator (sus scrofa) (aka hgf activator)
E:... | [C; M; R; A] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hgfl (homo sapiens) (macrophage stimulating 1 (homo sapiens)) (aka macrophage stimulating 1)
B: hgfal (homo sapiens) (aka hyaluronan binding protein 2)
C: hgf2 (homo sapiens) (aka gingival fibromatosis, hereditary, 2)
D: hgf (homo sapiens) (interleukin 6 (hom... | [L; I; Q; N] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: serpinf2 (homo sapiens) (aka serpin family f member 2)
B: hgf activator (rattus norvegicus) (aka hgf activator)
C: haik1 (homo sapiens) (aka keratin 23)
D: hai (homo sapiens) (serine peptidase inhibitor, kunitz type 1 (homo sapiens)) (aka serine peptidase inh... | [S; D; R; P] |
<Instruct>: Given the context 'Because HAI-2 and HAI-1 are potent inhibitors specific for HGF activator, they may be involved in regulation of proteolytic activation of HGF in injured tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, on... | <Mentions>: [hai-2; hai-1; hgf activator; hgf]
<Options>: A: hgf (homo sapiens) (interleukin 6 (homo sapiens)) (aka interleukin 6)
B: hcinf1 (homo sapiens) (aka cytochrome p450 family 24 subfamily a member 1)
C: haip1 (homo sapiens) (aka baculoviral iap repeat containing 3)
D: hgfal (homo sapiens) (aka hyaluronan bindi... | [Q; S; P; L] |
<Instruct>: Given the context 'Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [glycogenin-2]
<Options>: A: glycogenin 2 pseudogene 2 (homo sapiens) (aka glycogenin 2 pseudogene 2)
B: glycogenin 1 pseudogene 2 (homo sapiens) (aka glycogenin 1 pseudogene 2)
C: glycogenin 1 (homo sapiens) (aka glycogenin 1)
D: glycogenin 2 (homo sapiens) (aka glycogenin 2)
E: glycogenin 2 (sus scrofa) (... | [D] |
<Instruct>: Given the context 'We describe the characterization of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a second gene that is expressed preferentially in certain tissues, including liver, heart, and pancreas.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [glycogenin-2; gn-2]
<Options>: A: glycogenin 1 (homo sapiens) (aka glycogenin 1)
B: gnb2 (homo sapiens) (aka g protein subunit beta 2)
C: gng2 (homo sapiens) (aka g protein subunit gamma 2)
D: glycogenin 2 pseudogene 2 (homo sapiens) (aka glycogenin 2 pseudogene 2)
E: glycogenin 2 (xenopus tropicalis) (aka... | [F; F] |
<Instruct>: Given the context 'We describe the characterization of novel forms of glycogenin, designated glycogenin-2 (GN-2), encoded by a second gene that is expressed preferentially in certain tissues, including liver, heart, and pancreas.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [glycogenin-2; gn-2]
<Options>: A: gnp2 (homo sapiens) (aka glucosamine-6-phosphate deaminase 2)
B: gng2 (homo sapiens) (aka g protein subunit gamma 2)
C: glycogenin 2 (homo sapiens) (aka glycogenin 2)
D: glycogenin 2 pseudogene 2 (homo sapiens) (aka glycogenin 2 pseudogene 2)
E: gnb2 (homo sapiens) (aka g ... | [C; C] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: glycogenin 2 (gallus gallus) (aka glycogenin 2)
B: glycogenin 2 (bos taurus) (aka glycogenin 2)
C: gnai2a (homo sapiens) (aka g protein subunit alpha i2 pseudogene 1)
D: gnl2 (homo sapiens) (aka g protein nucleolar 2)
E: glycogen synthase 2 (xenop... | [J; J; J; J] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: gnl2 (homo sapiens) (aka g protein nucleolar 2)
B: gng5b (homo sapiens) (aka g protein subunit gamma 5b)
C: glycogenin 2 (bos taurus) (aka glycogenin 2)
D: glycogenin 2 (gallus gallus) (aka glycogenin 2)
E: glycogenin 1 pseudogene 2 (homo sapiens)... | [I; I; I; I] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: glycogenin 2 (sus scrofa) (aka glycogenin 2)
B: glycogenin 2 (homo sapiens) (aka glycogenin 2)
C: gng2 (homo sapiens) (aka g protein subunit gamma 2)
D: gng5b (homo sapiens) (aka g protein subunit gamma 5b)
E: glycogenin 2 (xenopus tropicalis) (ak... | [B; B; B; B] |
<Instruct>: Given the context 'Cloning of cDNAs encoding glycogenin-2 indicated the existence of multiple species, including three liver forms (GN-2alpha, GN-2beta, and GN-2gamma) generated in part by alternative splicing.', select the correct biomedical concept for each mention using the provided options. Answer by li... | <Mentions>: [glycogenin-2; gn-2alpha; gn-2beta; gn-2gamma]
<Options>: A: gng5b (homo sapiens) (aka g protein subunit gamma 5b)
B: glycogenin 2 (xenopus tropicalis) (aka glycogenin 2)
C: glycogenin 2 (sus scrofa) (aka glycogenin 2)
D: glycogenin 1 (homo sapiens) (aka glycogenin 1)
E: gnt2 (homo sapiens) (aka alpha-1,6-m... | [H; H; H; H] |
<Instruct>: Given the context 'Overall, GN-2 has 40-45% identity to muscle glycogenin but is 72% identical over a 200-residue segment thought to contain the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [gn-2; muscle glycogenin]
<Options>: A: gng2 (homo sapiens) (aka g protein subunit gamma 2)
B: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase)
C: gnp2 (homo sapiens) (aka glucosamine-6-phosphate deaminase 2)
D: liver glycogen phosphorylase (mus musculus) (aka... | [J; G] |
<Instruct>: Given the context 'Overall, GN-2 has 40-45% identity to muscle glycogenin but is 72% identical over a 200-residue segment thought to contain the catalytic domain.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention... | <Mentions>: [gn-2; muscle glycogenin]
<Options>: A: muscle glycogen phosphorylase (mus musculus) (aka muscle glycogen phosphorylase)
B: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
C: liver glycogen phosphorylase (mus musculus) (aka liver glycogen phosphorylase)
D: gnb2 (homo sapiens) (aka g protein ... | [I; G] |
<Instruct>: Given the context 'GN-2 expressed in Escherichia coli or COS cells is active in self-glucosylation assays, and self-glucosylated GN-2 can be elongated by skeletal muscle glycogen synthase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [gn-2; skeletal muscle glycogen synthase]
<Options>: A: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
B: gng2 (homo sapiens) (aka g protein subunit gamma 2)
C: lgs (mus musculus) (glycogen synthase 2 (mus musculus)) (aka glycogen synthase 2)
D: glycogenin 1 (mus musculus) (aka glycogenin 1... | [F; I] |
<Instruct>: Given the context 'GN-2 expressed in Escherichia coli or COS cells is active in self-glucosylation assays, and self-glucosylated GN-2 can be elongated by skeletal muscle glycogen synthase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opt... | <Mentions>: [gn-2; skeletal muscle glycogen synthase]
<Options>: A: gng2 (homo sapiens) (aka g protein subunit gamma 2)
B: glycogen [starch] synthase (caenorhabditis elegans) (aka glycogen [starch] synthase)
C: glycogen synthase 1 (homo sapiens) (aka glycogen synthase 1)
D: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-g... | [I; C] |
<Instruct>: Given the context 'Antibodies raised against GN-2 produced in E. coli recognized proteins of Mr approximately 66,000 present in extracts of rat liver and in cultured H4IIEC3 hepatoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected op... | <Mentions>: [gn-2]
<Options>: A: gn-2 (homo sapiens) (aka glycogenin 2)
B: gngt2 (homo sapiens) (aka g protein subunit gamma transducin 2)
C: gnp2 (homo sapiens) (aka glucosamine-6-phosphate deaminase 2)
D: gna-2 (caenorhabditis elegans) (aka glucosamine-phosphate n-acetyltransferase)
E: gnl2 (homo sapiens) (aka g prot... | [A] |
<Instruct>: Given the context 'In H4IIEC3 cells, most of the GN-2 was present as a free protein but some was covalently associated with glycogen fractions and was only released by treatment with alpha-amylase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the sel... | <Mentions>: [gn-2]
<Options>: A: gnb2 (homo sapiens) (aka g protein subunit beta 2)
B: gnt2 (homo sapiens) (aka alpha-1,6-mannosyl-glycoprotein 2-beta-n-acetylglucosaminyltransferase)
C: gna-2 (caenorhabditis elegans) (aka glucosamine-phosphate n-acetyltransferase)
D: gng2 (homo sapiens) (aka g protein subunit gamma 2)... | [E] |
<Instruct>: Given the context 'H4IIEC3 cells also expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chromatographically separable glycogen fraction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [muscle form of glycogenin; glycogenin-1]
<Options>: A: glycogenin 1 (mus musculus) (aka glycogenin 1)
B: glycogenin 2 (homo sapiens) (aka glycogenin 2)
C: brain glycogen phosphorylase (mus musculus) (aka brain glycogen phosphorylase)
D: liver glycogen phosphorylase (mus musculus) (aka liver glycogen phosph... | [E; E] |
<Instruct>: Given the context 'H4IIEC3 cells also expressed the muscle form of glycogenin (glycogenin-1), which was attached to a chromatographically separable glycogen fraction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each men... | <Mentions>: [muscle form of glycogenin; glycogenin-1]
<Options>: A: brain glycogen phosphorylase (mus musculus) (aka brain glycogen phosphorylase)
B: glycogenin-1 (caenorhabditis elegans) (aka glycogenin-1)
C: glycogenin 1 (rattus norvegicus) (aka glycogenin 1)
D: glycogenin 1 (gallus gallus) (aka glycogenin 1)
E: glyc... | [I; I] |
<Instruct>: Given the context 'hSK4, a member of a novel subfamily of calcium-activated potassium channels.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsk4]
<Options>: A: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
B: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
C: huk4 (homo sapiens) (aka phospholipase d family member 3)
D: map4k4 (homo sapiens) (aka mitogen-activated protein kinase k... | [A] |
<Instruct>: Given the context 'hSK4, a member of a novel subfamily of calcium-activated potassium channels.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hsk4]
<Options>: A: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
B: map4k4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 4)
C: mapkk4 (homo sapiens) (aka mitogen-activated protein kinase kinase 4)
D: huk4 (homo sapiens) (aka phospholipase d family ... | [E] |
<Instruct>: Given the context 'The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected opti... | <Mentions>: [hsk4]
<Options>: A: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
B: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
C: map4k4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 4)
D: ssk4 (saccharomyces cerevisiae s... | [B] |
<Instruct>: Given the context 'In physiological saline hSK4 generates a conductance of approximately 12 pS, a value in close agreement with that of other cloned SK channels.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention,... | <Mentions>: [hsk4]
<Options>: A: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
B: huk4 (homo sapiens) (aka phospholipase d family member 3)
C: mapkk4 (homo sapiens) (aka mitogen-activated protein kinase kinase 4)
D: stk4 (homo sapiens) (aka serine/threonine kinase 4)
E: ysk4 (homo s... | [A] |
<Instruct>: Given the context 'Like other members of this family, the polypeptide encoded by hSK4 contains a previously unnoted leucine zipper-like domain in its C terminus of unknown function.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, o... | <Mentions>: [hsk4]
<Options>: A: huk4 (homo sapiens) (aka phospholipase d family member 3)
B: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
C: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
D: map4k4 (homo sapiens) (aka mitogen-activated protein kinas... | [C] |
<Instruct>: Given the context 'hSK4 appears unique, however, in its very high affinity for Ca2+ (EC50 of 95 nM) and its predominant expression in nonexcitable tissues of adult animals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [hsk4]
<Options>: A: hbk4 (homo sapiens) (aka potassium voltage-gated channel subfamily a member 4)
B: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
C: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
D: stk4 (homo sapiens) (aka serine/threonin... | [B] |
<Instruct>: Given the context 'Together with the relatively low homology of hSK4 to other SK channel polypeptides (approximately 40% identical), these data suggest that hSK4 belongs to a novel subfamily of SK channels.', select the correct biomedical concept for each mention using the provided options. Answer by listin... | <Mentions>: [hsk4]
<Options>: A: ysk4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase 19)
B: map4k4 (homo sapiens) (aka mitogen-activated protein kinase kinase kinase kinase 4)
C: hsk4 (homo sapiens) (aka potassium calcium-activated channel subfamily n member 4)
D: serine/threonine kinase 4 (homo sap... | [C] |
<Instruct>: Given the context 'Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicol... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain]
<Options>: A: colony stimulating factor 3 receptor (homo sapiens) (aka colony stimulating factor 3 receptor)
B: colony stimulating factor 2 receptor subunit beta (bos taurus) (aka colony stimulating factor 2 receptor subunit beta)
C: colony stimulating factor 2 ... | [E] |
<Instruct>: Given the context 'In some cases congenital PAP is associated with hereditary surfactant protein (SP)-B deficiency.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [surfactant protein (sp)-b]
<Options>: A: sp-b (homo sapiens) (aka surfactant protein b)
B: surfactant protein b (sus scrofa) (aka surfactant protein b)
C: sftp1b (homo sapiens) (surfactant protein a2 (homo sapiens)) (aka surfactant protein a2)
D: surfactant protein b (bos taurus) (aka surfactant protein b)... | [A] |
<Instruct>: Given the context 'In mice, PAP has been generated by targeted deletion of the genes for either the GM-CSF/IL-3/IL-5 receptor common beta chain (beta c) or GM-CSF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain; beta c]
<Options>: A: csf3r (homo sapiens) (aka colony stimulating factor 3 receptor)
B: betacellulin (homo sapiens) (aka betacellulin)
C: g protein subunit beta 3 (homo sapiens) (aka g protein subunit beta 3)
D: il5r (homo sapiens) (aka interleukin 5 receptor s... | [F; F] |
<Instruct>: Given the context 'In mice, PAP has been generated by targeted deletion of the genes for either the GM-CSF/IL-3/IL-5 receptor common beta chain (beta c) or GM-CSF.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mentio... | <Mentions>: [gm-csf/il-3/il-5 receptor common beta chain; beta c]
<Options>: A: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta)
B: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
C: casein beta (homo sapiens) (aka casein bet... | [F; F] |
<Instruct>: Given the context 'Here, we describe an expression defect of beta c in three of seven pediatric patients with PAP and in one patient with severe lung disease suspected to be PAP.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one ... | <Mentions>: [beta c]
<Options>: A: betan (homo sapiens) (aka dna polymerase lambda)
B: casein beta (homo sapiens) (aka casein beta)
C: beta-5 (homo sapiens) (aka tubulin beta 4a class iva)
D: beta3 (homo sapiens) (aka basic helix-loop-helix family member e22)
E: inhibin subunit beta c (homo sapiens) (aka inhibin subuni... | [F] |
<Instruct>: Given the context 'The patients failed to express normal levels of beta c as shown by flow cytometry.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta c]
<Options>: A: inhibin subunit beta c (homo sapiens) (aka inhibin subunit beta c)
B: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
C: betan (homo sapiens) (aka dna polymerase lambda)
D: beta-5 (homo sapiens) (aka tubulin beta 4a class iva)
E: g pr... | [F] |
<Instruct>: Given the context 'Strikingly reduced or absent function of beta c was demonstrated by ligand binding studies and progenitor clonogenic assays.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semi... | <Mentions>: [beta c]
<Options>: A: beta3b (homo sapiens) (aka basic helix-loop-helix family member e23)
B: inhibin subunit beta c (homo sapiens) (aka inhibin subunit beta c)
C: casein beta (homo sapiens) (aka casein beta)
D: beta3 (homo sapiens) (aka basic helix-loop-helix family member e22)
E: betan (homo sapiens) (ak... | [F] |
<Instruct>: Given the context 'Analysis of beta c DNA revealed a point mutation from proline to threonine at codon 602 in one patient.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [beta c]
<Options>: A: betan (homo sapiens) (aka dna polymerase lambda)
B: betacellulin (homo sapiens) (aka betacellulin)
C: beta3b (homo sapiens) (aka basic helix-loop-helix family member e23)
D: propionyl-coa carboxylase subunit beta (homo sapiens) (aka propionyl-coa carboxylase subunit beta)
E: beta-3 (h... | [F] |
<Instruct>: Given the context 'Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [quinolinate phosphoribosyltransferase]
<Options>: A: quinolinate phosphoribosyltransferase (rattus norvegicus) (aka quinolinate phosphoribosyltransferase)
B: quinolinate phosphoribosyltransferase (homo sapiens) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus tropicalis) (aka quinolinate phosph... | [B] |
<Instruct>: Given the context 'Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [quinolinate phosphoribosyltransferase; qprtase]
<Options>: A: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
B: quinolinate phosphoribosyltransferase (gallus gallus) (aka quinolinate phosphoribosyltransferase)
C: quinolinate phosphoribosyltransferase ... | [E; E] |
<Instruct>: Given the context 'Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [quinolinate phosphoribosyltransferase; qprtase]
<Options>: A: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
B: quinolinate phosphoribosyltransferase (mus musculus) (aka quinolinate phosphoribosyltransferase)
C: quinolinate phosphoribosyltransferase (... | [C; C] |
<Instruct>: Given the context 'Mammalian quinolinate phosphoribosyltransferase (QPRTase) (EC 2.4.2.19) is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide (NAD) pathway.', select the correct biomedical concept for each mention using the provided options. Ans... | <Mentions>: [quinolinate phosphoribosyltransferase; qprtase]
<Options>: A: qprt (xenopus laevis) (aka quinolinate phosphoribosyltransferase l homeolog)
B: quinolinate phosphoribosyltransferase (xenopus tropicalis) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus tropicalis) (aka quinolinate phosphoribosyltr... | [I; I] |
<Instruct>: Given the context 'As the first step to elucidate molecular basis underlying the quinolinate metabolism, the cDNA encoding human brain QPRTase was cloned and characterized.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [qprtase]
<Options>: A: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
B: qprt (homo sapiens) (aka quinolinate phosphoribosyltransferase)
C: qprt (xenopus tropicalis) (aka quinolinate phosphoribosyltransferase)
D: quinolinate phosphoribosyltransferase ... | [B] |
<Instruct>: Given the context 'Utilizing partial amino acid sequences obtained from highly purified porcine kidney QPRTase, a human isolog was obtained from a human brain cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for ea... | <Mentions>: [qprtase]
<Options>: A: prophage antitermination protein q homolog quud (escherichia coli str. k-12 substr. mg1655) (aka prophage antitermination protein q homolog quud)
B: qprt (homo sapiens) (aka quinolinate phosphoribosyltransferase)
C: qprtase (mus musculus) (aka quinolinate phosphoribosyltransferase)
D... | [E] |
<Instruct>: Given the context 'To confirm that the cDNA clone encodes human QPRTase, its functional expression was studied in a bacterial host.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [qprtase]
<Options>: A: prophage antitermination protein q homolog quud (escherichia coli str. k-12 substr. mg1655) (aka prophage antitermination protein q homolog quud)
B: quinolinate phosphoribosyltransferase (decarboxylating) (escherichia coli str. k-12 substr. mg1655) (aka quinolinate phosphoribosyltran... | [E] |
<Instruct>: Given the context 'Introduction of the human cDNA into a QPRTase defective (nadC) E. coli strain brought about an abrupt increase in QPRTase activity and allowed the cells to grow in the absence of nicotinic acid.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [qprtase; nadc]
<Options>: A: quinolinate phosphoribosyltransferase (sus scrofa) (aka quinolinate phosphoribosyltransferase)
B: nad1 (saccharomyces cerevisiae s288c) (aka 40s ribosomal protein rack1 asc1)
C: qprt (xenopus tropicalis) (aka quinolinate phosphoribosyltransferase)
D: nedscac (homo sapiens) (aka... | [I; I] |
<Instruct>: Given the context 'Introduction of the human cDNA into a QPRTase defective (nadC) E. coli strain brought about an abrupt increase in QPRTase activity and allowed the cells to grow in the absence of nicotinic acid.', select the correct biomedical concept for each mention using the provided options. Answer by... | <Mentions>: [qprtase; nadc]
<Options>: A: qprt (xenopus laevis) (aka quinolinate phosphoribosyltransferase l homeolog)
B: glnq (escherichia coli str. k-12 substr. mg1655) (aka l-glutamine abc transporter atp binding subunit)
C: prophage antitermination protein q homolog quud (escherichia coli str. k-12 substr. mg1655) ... | [F; F] |
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