instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'This cancer-prone phenotype may correlate with the enhanced ability of several mxi1-deficient cell types, including prostatic epithelium, to proliferate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: mx1 (mus musculus) (aka mx dynamin-like gtpase 1)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
C: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
D: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
E: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1; myc]
<Options>: A: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
B: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
C: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
D: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
E: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
F: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
G: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
H: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
I: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
J: myc proto-oncogene, bhlh transcription factor (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
K: None of the above. | [D; J] |
<Instruct>: Given the context 'Our results show that Mxi1 is involved in the homeostasis of differentiated organ systems, acts as a tumour suppressor in vivo, and engages the Myc network in a functionally relevant manner.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1; myc]
<Options>: A: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
D: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
E: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
F: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
G: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
H: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
I: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
J: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
K: None of the above. | [I; C] |
<Instruct>: Given the context 'DNA sequence and muscle-specific expression of human sarcosin transcripts.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcospan (bos taurus) (aka sarcospan)
B: sarcospan (homo sapiens) (aka sarcospan)
C: sarcosin (danio rerio) (aka kelch-like family member 41b)
D: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
E: sarcosin (homo sapiens) (aka kelch like family member 41)
F: None of the above. | [E] |
<Instruct>: Given the context 'Consequently, we have termed this novel human sequence sarcosin.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcc (homo sapiens) (aka purinergic receptor p2y1)
B: sarcosin (danio rerio) (aka kelch-like family member 41b)
C: sarcosinemia autosomal recessive (mus musculus) (aka sarcosinemia autosomal recessive)
D: sarcosin (rattus norvegicus) (aka kelch-like family member 41)
E: sarcosin (homo sapiens) (aka kelch like family member 41)
F: None of the above. | [E] |
<Instruct>: Given the context 'Although novel, Southern hybridization analysis demonstrated that the sarcosin sequence has been conserved in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [sarcosin]
<Options>: A: sarcc (homo sapiens) (aka purinergic receptor p2y1)
B: sarcospan (bos taurus) (aka sarcospan)
C: sarcosin (xenopus tropicalis) (aka kelch like family member 41)
D: sarcosin (homo sapiens) (aka kelch like family member 41)
E: sarcosin (danio rerio) (aka kelch-like family member 41b)
F: None of the above. | [D] |
<Instruct>: Given the context 'Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration characterized by an abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmd2]
<Options>: A: vmd2l3 (homo sapiens) (aka bestrophin 3)
B: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
C: vmd2 (homo sapiens) (aka bestrophin 1)
D: vm2 (drosophila melanogaster) (aka visible mutation-2)
E: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
F: None of the above. | [C] |
<Instruct>: Given the context 'In pursuit of the disease gene, we limited the minimum genetic region by recombination breakpoint analysis and mapped to this region a novel retina-specific gene (VMD2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmd2]
<Options>: A: vmd2l2 (homo sapiens) (aka bestrophin 4)
B: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
C: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
D: vmd2 (homo sapiens) (aka bestrophin 1)
E: mc4dn2 (homo sapiens) (aka synthesis of cytochrome c oxidase 2)
F: None of the above. | [D] |
<Instruct>: Given the context 'In pursuit of the disease gene, we limited the minimum genetic region by recombination breakpoint analysis and mapped to this region a novel retina-specific gene (VMD2).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [vmd2]
<Options>: A: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
B: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
C: vmd2l2 (homo sapiens) (aka bestrophin 4)
D: mc4dn2 (homo sapiens) (aka synthesis of cytochrome c oxidase 2)
E: None of the above. | [E] |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fth1; vmd2]
<Options>: A: vmd2l3 (homo sapiens) (aka bestrophin 3)
B: ft1a (homo sapiens) (aka fucosyltransferase 6)
C: ft1 (homo sapiens) (aka akt interacting protein)
D: vmd2 (homo sapiens) (aka bestrophin 1)
E: mvcd2 (homo sapiens) (aka erythropoietin)
F: vmd2l1 (homo sapiens) (aka bestrophin 2)
G: vmd2 (mus musculus) (aka bestrophin 1)
H: fthp1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 5)
I: fthfd (homo sapiens) (aka aldehyde dehydrogenase 1 family member l1)
J: fth1 (homo sapiens) (aka ferritin heavy chain 1)
K: None of the above. | [J; D] |
<Instruct>: Given the context 'The 3' UTR of the candidate gene contains a region of antisense complementarity to the 3' UTR of the ferritin heavy-chain gene (FTH1), indicating the possibility of antisense interaction between VMD2 and FTH1 transcripts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [fth1; vmd2]
<Options>: A: fer1 (drosophila melanogaster) (ferritin 1 heavy chain homologue (drosophila melanogaster)) (aka ferritin 1 heavy chain homologue)
B: mvcd2 (homo sapiens) (aka erythropoietin)
C: fth (homo sapiens) (aka ferritin heavy chain 1)
D: vmd1 (homo sapiens) (aka vitelliform macular dystrophy, atypical)
E: fthp1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 5)
F: vmd4 (homo sapiens) (aka interphotoreceptor matrix proteoglycan 1)
G: fth1p1 (homo sapiens) (aka ferritin heavy chain 1 pseudogene 1)
H: vmd2 (homo sapiens) (aka bestrophin 1)
I: ft1a (homo sapiens) (aka fucosyltransferase 6)
J: vmd2l3 (homo sapiens) (aka bestrophin 3)
K: None of the above. | [C; H] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: dna helicase b (homo sapiens) (aka dna helicase b)
B: breast cancer type 2 susceptibility protein homolog (caenorhabditis elegans) (aka breast cancer type 2 susceptibility protein homolog)
C: ribosomal rna processing 7 homolog a (homo sapiens) (aka ribosomal rna processing 7 homolog a)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
E: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
F: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
G: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
H: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
I: helicase (homo sapiens) (aka helicase for meiosis 1)
J: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
K: brca1 (homo sapiens) (aka brca1 dna repair associated)
L: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
M: None of the above. | [K; H; K] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1/brca2-containing complex subunit 3 (homo sapiens) (aka brca1/brca2-containing complex subunit 3)
C: ribosomal rna processing 7 homolog a (homo sapiens) (aka ribosomal rna processing 7 homolog a)
D: brca1 (homo sapiens) (aka brca1 dna repair associated)
E: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
F: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
G: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
H: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
I: bcds1 (homo sapiens) (cancer, familial, with in vitro radioresistance (homo sapiens)) (aka cancer, familial, with in vitro radioresistance)
J: mex-3 rna binding family member a (homo sapiens) (aka mex-3 rna binding family member a)
K: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
L: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
M: None of the above. | [D; F; D] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: brca1 (homo sapiens) (aka brca1 dna repair associated)
B: mex-3 rna binding family member a (homo sapiens) (aka mex-3 rna binding family member a)
C: bcds1 (homo sapiens) (cancer, familial, with in vitro radioresistance (homo sapiens)) (aka cancer, familial, with in vitro radioresistance)
D: brca1/brca2-containing complex subunit 3 (homo sapiens) (aka brca1/brca2-containing complex subunit 3)
E: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
F: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
G: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
H: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
I: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
J: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
K: ribosomal rna processing 7 homolog a (homo sapiens) (aka ribosomal rna processing 7 homolog a)
L: None of the above. | [A; L; A] |
<Instruct>: Given the context 'BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A.
The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain and is a component of the RNA polymerase II (Pol II) holoenzyme.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rna helicase a; breast cancer specific tumour suppressor protein]
<Options>: A: helicase (homo sapiens) (aka helicase for meiosis 1)
B: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
C: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
D: bcds1 (homo sapiens) (cancer, familial, with in vitro radioresistance (homo sapiens)) (aka cancer, familial, with in vitro radioresistance)
E: brca1/brca2-containing complex subunit 3 (homo sapiens) (aka brca1/brca2-containing complex subunit 3)
F: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
G: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
H: dna helicase b (homo sapiens) (aka dna helicase b)
I: brca1 (homo sapiens) (aka brca1 dna repair associated)
J: pseudo-brca1 (homo sapiens) (aka brca1 pseudogene 1)
K: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
L: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
M: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
N: atp-dependent rna helicase a;rna helicase (caenorhabditis elegans) (aka atp-dependent rna helicase a;rna helicase)
O: None of the above. | [I; G; I] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: brca1 (homo sapiens) (aka brca1 dna repair associated)
B: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
C: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
F: rh50a (homo sapiens) (aka rh associated glycoprotein)
G: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
H: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
I: dna helicase b (homo sapiens) (aka dna helicase b)
J: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
K: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
L: swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog (caenorhabditis elegans) (aka swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog)
M: rhs (homo sapiens) (aka tumor protein p63)
N: rhc (homo sapiens) (aka rh blood group ccee antigens)
O: None of the above. | [G; G; A] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog (caenorhabditis elegans) (aka swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog)
B: brca1 (homo sapiens) (aka brca1 dna repair associated)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: rhag (homo sapiens) (aka rh associated glycoprotein)
E: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
F: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
G: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
H: mex-3 rna binding family member a (homo sapiens) (aka mex-3 rna binding family member a)
I: rhna (homo sapiens) (aka rh blood group ccee antigens)
J: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
K: dna helicase b (homo sapiens) (aka dna helicase b)
L: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
M: brca1p1 (homo sapiens) (aka brca1 pseudogene 1)
N: rhs (homo sapiens) (aka tumor protein p63)
O: None of the above. | [E; E; B] |
<Instruct>: Given the context 'We show here that RNA helicase A (RHA) protein links BRCA1 to the holoenzyme complex.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rna helicase a; rha; brca1]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: ras homolog family member a (homo sapiens) (aka ras homolog family member a)
C: mex-3 rna binding family member a (homo sapiens) (aka mex-3 rna binding family member a)
D: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
E: rhd (homo sapiens) (aka rh blood group d antigen)
F: swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog (caenorhabditis elegans) (aka swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a containing dead/h box 1 homolog)
G: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
H: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
I: rhc (homo sapiens) (aka rh blood group ccee antigens)
J: rhs (homo sapiens) (aka tumor protein p63)
K: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
L: dexh-box helicase 9 (homo sapiens) (aka dexh-box helicase 9)
M: brca1 (homo sapiens) (aka brca1 dna repair associated)
N: dexd-box helicase 39a (homo sapiens) (aka dexd-box helicase 39a)
O: None of the above. | [L; L; M] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rha]
<Options>: A: rha (homo sapiens) (aka dexh-box helicase 9)
B: rhs (homo sapiens) (aka tumor protein p63)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: rhr (homo sapiens) (aka adrenoceptor beta 1)
E: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
F: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
G: rhag (homo sapiens) (aka rh associated glycoprotein)
H: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
I: brca1 (homo sapiens) (aka brca1 dna repair associated)
J: rhd (homo sapiens) (aka rh blood group d antigen)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'The region of BRCA1 which interacts with RHA and, thus, the holoenzyme complex, corresponds to subregions of the BRCT domain of BRCA1 (ref. 9).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1; rha]
<Options>: A: rhna (homo sapiens) (aka rh blood group ccee antigens)
B: rhr (homo sapiens) (aka adrenoceptor beta 1)
C: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
D: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
E: rha (homo sapiens) (aka dexh-box helicase 9)
F: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
G: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
H: brca1 (homo sapiens) (aka brca1 dna repair associated)
I: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
J: rh50a (homo sapiens) (aka rh associated glycoprotein)
K: None of the above. | [H; E] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rha; brca1]
<Options>: A: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
B: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
C: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
D: rha (homo sapiens) (aka dexh-box helicase 9)
E: rh50a (homo sapiens) (aka rh associated glycoprotein)
F: rhr (homo sapiens) (aka adrenoceptor beta 1)
G: brca1 dna repair associated (homo sapiens) (aka brca1 dna repair associated)
H: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
I: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
J: rhs (homo sapiens) (aka tumor protein p63)
K: None of the above. | [D; G] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rha; brca1]
<Options>: A: rhs (homo sapiens) (aka tumor protein p63)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: brca1 (homo sapiens) (aka brca1 dna repair associated)
D: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
E: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
F: rhc (homo sapiens) (aka rh blood group ccee antigens)
G: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
H: rh associated glycoprotein (homo sapiens) (aka rh associated glycoprotein)
I: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
J: rha (homo sapiens) (aka dexh-box helicase 9)
K: None of the above. | [J; C] |
<Instruct>: Given the context 'This interaction was shown to occur in yeast nuclei, and expression in human cells of a truncated RHA molecule which retains binding to BRCA1 inhibited transcriptional activation mediated by the BRCA1 carboxy terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rha; brca1]
<Options>: A: brcaa1 (homo sapiens) (aka at-rich interaction domain 4b)
B: brca1 (homo sapiens) (aka brca1 dna repair associated)
C: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
D: rhs (homo sapiens) (aka tumor protein p63)
E: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
F: brca1 pseudogene 1 (homo sapiens) (aka brca1 pseudogene 1)
G: rhc (homo sapiens) (aka rh blood group ccee antigens)
H: rh associated glycoprotein (homo sapiens) (aka rh associated glycoprotein)
I: rhfca (homo sapiens) (aka cytochrome p450 family 26 subfamily b member 1)
J: None of the above. | [J; B] |
<Instruct>: Given the context 'These data are the first to identify a specific protein interaction with the BRCA1 C-terminal domain and are consistent with the model that BRCA1 functions as a transcriptional coactivator.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [brca1]
<Options>: A: brca1 promoter region (homo sapiens) (aka brca1 promoter region)
B: brisc and brca1 a complex member 1 (homo sapiens) (aka brisc and brca1 a complex member 1)
C: breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1 (caenorhabditis elegans) (aka breast cancer type 1 susceptibility protein homolog;ring-type e3 ubiquitin transferase brca1)
D: brca1 (homo sapiens) (aka brca1 dna repair associated)
E: brca1 associated protein (homo sapiens) (aka brca1 associated protein)
F: None of the above. | [D] |
<Instruct>: Given the context 'Recently, a suitable candidate gene, CNGA3, encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel, a key component of the phototransduction pathway, has been cloned and assigned to human chromosome 2q11 (refs 3,4).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cnga3]
<Options>: A: cnga1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: cna3 (homo sapiens) (aka protein phosphatase 3 catalytic subunit gamma)
C: cnga4 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 4)
D: cnga3 (sus scrofa) (aka cyclic nucleotide gated channel subunit alpha 3)
E: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
F: None of the above. | [E] |
<Instruct>: Given the context 'We report the identification of missense mutations in CNGA3 in five families with RM.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cnga3]
<Options>: A: cnga1 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 1)
B: cnga3 (xenopus tropicalis) (aka cyclic nucleotide gated channel alpha 3)
C: cnga3 (sus scrofa) (aka cyclic nucleotide gated channel subunit alpha 3)
D: cnga3 (homo sapiens) (aka cyclic nucleotide gated channel subunit alpha 3)
E: cnga3.l (xenopus laevis) (aka cyclic nucleotide gated channel alpha 3 l homeolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2) maps to a 1.1-Mb region in Xp11.23 between markers DXS722 and DXS255.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csnb2]
<Options>: A: csnb1 (homo sapiens) (aka nyctalopin)
B: csnb2b (homo sapiens) (aka calcium binding protein 4)
C: csnb2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnk2b (homo sapiens) (aka casein kinase 2 beta)
E: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
F: None of the above. | [C] |
<Instruct>: Given the context 'We identified a retina-specific calcium channel alpha1-subunit gene (CACNA1F) in this region, consisting of 48 exons encoding 1966 amino acids and showing high homology to L-type calcium channel alpha1-subunits.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cacna1f]
<Options>: A: cacna1f (xenopus tropicalis) (aka calcium channel, voltage-dependent, l type, alpha 1f subunit)
B: cacna1h (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 h)
C: cacna1f (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: cacna1f (sus scrofa) (aka calcium voltage-gated channel subunit alpha1 f)
E: cacna1f (xenopus laevis) (aka calcium channel, voltage-dependent, l type, alpha 1f subunit l homeolog)
F: None of the above. | [C] |
<Instruct>: Given the context 'Mutation analysis in 13 families with CSNB2 revealed nine different mutations in 10 families, including three nonsense and one frameshift mutation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csnb2]
<Options>: A: csnb2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
B: csn2 (bos taurus) (aka casein beta)
C: csn1s2b (homo sapiens) (aka casein alpha s2 like b, pseudogene)
D: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
E: csnb1c (homo sapiens) (aka transient receptor potential cation channel subfamily m member 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'These data indicate that aberrations in a voltage-gated calcium channel, presumably causing a decrease in neurotransmitter release from photoreceptor presynaptic terminals, are a frequent cause of CSNB2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [csnb2]
<Options>: A: csnb1 (homo sapiens) (aka nyctalopin)
B: csnb1b (homo sapiens) (aka glutamate metabotropic receptor 6)
C: csnbx2 (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 f)
D: csnb2b (homo sapiens) (aka calcium binding protein 4)
E: csn2 (bos taurus) (aka casein beta)
F: None of the above. | [C] |
<Instruct>: Given the context 'ZW10 helps recruit dynactin and dynein to the kinetochore.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
B: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
C: zw10 (drosophila melanogaster) (aka zeste-white 10)
D: zw10 (homo sapiens) (aka zw10 kinetochore protein)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
F: None of the above. | [D] |
<Instruct>: Given the context 'Mutations in the Drosophila melanogaster zw10 gene, which encodes a conserved, essential kinetochore component, abolish the ability of dynein to localize to kinetochores.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw10 (homo sapiens) (aka zw10 kinetochore protein)
B: zw-10 (drosophila melanogaster) (aka zeste-white 10)
C: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
D: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
E: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
F: None of the above. | [B] |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw-10 (drosophila melanogaster) (aka zeste-white 10)
B: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
C: zw10 (danio rerio) (aka zw10 kinetochore protein)
D: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
E: zw10 (homo sapiens) (aka zw10 kinetochore protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'Several similarities between the behavior of ZW10 protein and dynein further support a role for ZW10 in the recruitment of dynein to the kinetochore: (a) in response to bipolar tension across the chromosomes, both proteins mostly leave the kinetochore at metaphase, when their association with the spindle becomes apparent; (b) ZW10 and dynein both bind to functional neocentromeres of structurally acentric minichromosomes; and (c) the localization of both ZW10 and dynein to the kinetochore is abolished in cells mutant for the gene rough deal.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
B: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
C: zw10 (danio rerio) (aka zw10 kinetochore protein)
D: zw-10 (drosophila melanogaster) (aka zeste-white 10)
E: None of the above. | [E] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10; dynamitin]
<Options>: A: dynactin subunit 1 (homo sapiens) (aka dynactin subunit 1)
B: dynamitin (xenopus laevis) (dynactin subunit 2 l homeolog (xenopus laevis)) (aka dynactin subunit 2 l homeolog)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
E: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
F: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_f20d12.4 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
G: zw10 (danio rerio) (aka zw10 kinetochore protein)
H: dynamitin (homo sapiens) (aka dynactin subunit 2)
I: drn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
J: dynamitin (xenopus laevis) (dynactin subunit 2 s homeolog (xenopus laevis)) (aka dynactin subunit 2 s homeolog)
K: None of the above. | [C; H] |
<Instruct>: Given the context 'ZW10's role in the recruitment of dynein to the kinetochore is likely to be reasonably direct, because dynamitin, the p50 subunit of the dynactin complex, interacts with ZW10 in a yeast two-hybrid screen.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10; dynamitin]
<Options>: A: dynamitin (xenopus tropicalis) (aka dynactin subunit 2)
B: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
C: zw10 (homo sapiens) (aka zw10 kinetochore protein)
D: dynamitin (xenopus laevis) (dynactin subunit 2 s homeolog (xenopus laevis)) (aka dynactin subunit 2 s homeolog)
E: dynamitin (homo sapiens) (aka dynactin subunit 2)
F: zw10 (xenopus laevis) (zw10 kinetochore protein s homeolog (xenopus laevis)) (aka zw10 kinetochore protein s homeolog)
G: drn (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
H: dynamitin (xenopus laevis) (dynactin subunit 2 l homeolog (xenopus laevis)) (aka dynactin subunit 2 l homeolog)
I: zw10 (danio rerio) (aka zw10 kinetochore protein)
J: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
K: None of the above. | [C; E] |
<Instruct>: Given the context 'Since in zw10 mutants no defects in chromosome behavior are observed before anaphase onset, our results suggest that dynein at the kinetochore is essential for neither microtubule capture nor congression to the metaphase plate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [zw10]
<Options>: A: zw10 kinetochore protein s homeolog (xenopus laevis) (aka zw10 kinetochore protein s homeolog)
B: centromere/kinetochore protein zw10 homolog (caenorhabditis elegans) (cele_d2030.11 (caenorhabditis elegans)) (aka centromere/kinetochore protein zw10 homolog)
C: zw10 (danio rerio) (aka zw10 kinetochore protein)
D: zw10 (xenopus tropicalis) (aka zw10 kinetochore protein)
E: zw10 (homo sapiens) (aka zw10 kinetochore protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: ifi27 (homo sapiens) (aka interferon alpha inducible protein 27)
D: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
E: nod16 (homo sapiens) (aka nlr family pyrin domain containing 8)
F: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
G: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
H: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations.
IFI 16 is an interferon-inducible nucleoprotein expressed by human monocytes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifn-inducible nucleoprotein ifi 16; ifi 16]
<Options>: A: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
D: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
E: ifi16 (mus musculus) (aka interferon activated gene 204)
F: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
G: ifi27 (homo sapiens) (aka interferon alpha inducible protein 27)
H: ifi10 (homo sapiens) (aka c-x-c motif chemokine ligand 10)
I: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: p200b (homo sapiens) (aka heat repeat containing 5a)
B: cg12032 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
C: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
D: rbb (homo sapiens) (aka nacc family member 2)
E: rb-1 (homo sapiens) (aka rna binding motif protein 45)
F: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
G: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
H: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
I: p105-rb (homo sapiens) (aka rb transcriptional corepressor 1)
J: rad53 (homo sapiens) (aka checkpoint kinase 2)
K: ct53 (homo sapiens) (aka zinc finger protein 165)
L: tumor protein p53 (homo sapiens) (aka tumor protein p53)
M: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
N: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional corepressor like 1)
O: prb2 (homo sapiens) (aka proline rich protein bstni subfamily 2)
P: tumor protein p73 (homo sapiens) (aka tumor protein p73)
Q: tppp/p20 (homo sapiens) (aka tubulin polymerization promoting protein family member 3)
R: p200 (homo sapiens) (heat repeat containing 5b (homo sapiens)) (aka heat repeat containing 5b)
S: p200 (homo sapiens) (arf guanine nucleotide exchange factor 1 (homo sapiens)) (aka arf guanine nucleotide exchange factor 1)
T: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
U: None of the above. | [M; U; L; I] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: tp73 (homo sapiens) (aka tumor protein p73)
B: rbb (homo sapiens) (aka nacc family member 2)
C: prb2 (homo sapiens) (aka proline rich protein bstni subfamily 2)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
F: p28 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
G: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
H: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
I: ifi16 (mus musculus) (aka interferon activated gene 204)
J: cg12032 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
K: p53cp (homo sapiens) (aka tumor protein p63)
L: tppp/p20 (homo sapiens) (aka tubulin polymerization promoting protein family member 3)
M: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
N: p53 (homo sapiens) (aka tumor protein p53)
O: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
P: prb (homo sapiens) (aka rb transcriptional corepressor 1)
Q: p200 (homo sapiens) (at-rich interaction domain 2 (homo sapiens)) (aka at-rich interaction domain 2)
R: rad53 (homo sapiens) (aka checkpoint kinase 2)
S: p200a (homo sapiens) (aka heat repeat containing 5b)
T: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
U: None of the above. | [T; U; N; P] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: p53cp (homo sapiens) (aka tumor protein p63)
C: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
D: tumor protein p53 (homo sapiens) (aka tumor protein p53)
E: prb2 (homo sapiens) (aka proline rich protein bstni subfamily 2)
F: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
G: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
H: rb-1 (homo sapiens) (aka rna binding motif protein 45)
I: cg12032 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
J: p200 (homo sapiens) (arf guanine nucleotide exchange factor 1 (homo sapiens)) (aka arf guanine nucleotide exchange factor 1)
K: rad53 (homo sapiens) (aka checkpoint kinase 2)
L: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
M: ct53 (homo sapiens) (aka zinc finger protein 165)
N: tppp/p20 (homo sapiens) (aka tubulin polymerization promoting protein family member 3)
O: prb (homo sapiens) (aka rb transcriptional corepressor 1)
P: p28 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
Q: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2)
R: p200b (homo sapiens) (aka heat repeat containing 5a)
S: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
T: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
U: None of the above. | [F; U; D; O] |
<Instruct>: Given the context 'IFI 16 and a related mouse protein, p202, control cellular proliferation by binding and modulating the functions of cell cycle regulatory factors including p53 and the retinoblastoma gene product, pRb.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; p202; p53; retinoblastoma gene product, prb]
<Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: p202 (homo sapiens) (aka tumor protein p53 binding protein 1)
C: rbb (homo sapiens) (aka nacc family member 2)
D: p53 (homo sapiens) (aka tumor protein p53)
E: prb1 (homo sapiens) (rb transcriptional corepressor like 1 (homo sapiens)) (aka rb transcriptional corepressor like 1)
F: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
G: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
H: cg12032 (drosophila melanogaster) (uncharacterized protein (drosophila melanogaster)) (aka uncharacterized protein)
I: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
J: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
K: rad53 (homo sapiens) (aka checkpoint kinase 2)
L: tumor protein p73 (homo sapiens) (aka tumor protein p73)
M: p200a (homo sapiens) (aka heat repeat containing 5b)
N: p53cp (homo sapiens) (aka tumor protein p63)
O: rb-1 (homo sapiens) (aka rna binding motif protein 45)
P: p200 (homo sapiens) (at-rich interaction domain 2 (homo sapiens)) (aka at-rich interaction domain 2)
Q: rb (homo sapiens) (aka rb transcriptional corepressor 1)
R: p28 (drosophila melanogaster) (tbp-associated factor 12 (drosophila melanogaster)) (aka tbp-associated factor 12)
S: ct53 (homo sapiens) (aka zinc finger protein 165)
T: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein)
U: None of the above. | [I; U; D; Q] |
<Instruct>: Given the context 'In this study, we examined IFI 16 expression in myeloid precursor cells cultured in vitro in colony-forming assays using granulocyte (G-) and granulocyte-macrophage (GM-) colony-stimulating factor (CSF).', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16]
<Options>: A: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
B: ifi16 (mus musculus) (aka interferon activated gene 204)
C: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
E: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
F: None of the above. | [C] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
B: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: ifi16 (mus musculus) (aka interferon activated gene 204)
D: cd34 (sus scrofa) (aka cd34 molecule)
E: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
F: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
G: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
H: cd344 (homo sapiens) (aka frizzled class receptor 4)
I: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
J: cd34 molecule (homo sapiens) (aka cd34 molecule)
K: None of the above. | [B; J] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: cd34 (sus scrofa) (aka cd34 molecule)
B: fat4 (homo sapiens) (aka fat atypical cadherin 4)
C: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
D: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
E: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
F: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
G: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
H: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
I: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
J: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
K: None of the above. | [I; J] |
<Instruct>: Given the context 'IFI 16 was expressed in 100% of CD34+ cells isolated from human bone marrow.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: fat4 (homo sapiens) (aka fat atypical cadherin 4)
D: cd34 (sus scrofa) (aka cd34 molecule)
E: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
F: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
G: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
H: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
I: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
J: None of the above. | [F; J] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
C: cd14 (oryctolagus cuniculus) (aka cd14 molecule)
D: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
E: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
F: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
G: cd34 molecule (gallus gallus) (aka cd34 molecule)
H: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
I: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
J: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
K: fat4 (homo sapiens) (aka fat atypical cadherin 4)
L: cd147 (homo sapiens) (aka basigin (ok blood group))
M: ifi16 (mus musculus) (aka interferon activated gene 204)
N: cd344 (homo sapiens) (aka frizzled class receptor 4)
O: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
P: None of the above. | [O; D; A] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: ifi16 (mus musculus) (aka interferon activated gene 204)
B: cd344 (homo sapiens) (aka frizzled class receptor 4)
C: cd141 (homo sapiens) (aka thrombomodulin)
D: cd148 (homo sapiens) (aka protein tyrosine phosphatase receptor type j)
E: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
F: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
G: cd146 (homo sapiens) (aka melanoma cell adhesion molecule)
H: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
I: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
J: cd34 molecule (gallus gallus) (aka cd34 molecule)
K: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
L: cd14 molecule (oryctolagus cuniculus) (aka cd14 molecule)
M: cd14 molecule (homo sapiens) (aka cd14 molecule)
N: cd34 (sus scrofa) (aka cd34 molecule)
O: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
P: None of the above. | [E; M; H] |
<Instruct>: Given the context 'When the CD34+ cells were induced to differentiate, two sub-populations of cells were identified by two-color cytofluorography: the CD14+ (monocytoid) cells all expressed IFI 16, whereas the CD14- (polymorphonuclear precursor) cells did not.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cd34; cd14; ifi 16]
<Options>: A: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
B: cd148 (homo sapiens) (aka protein tyrosine phosphatase receptor type j)
C: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
D: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
E: cd34 (gallus gallus) (aka cd34 molecule)
F: cd141 (homo sapiens) (aka thrombomodulin)
G: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
H: cd34 molecule (homo sapiens) (aka cd34 molecule)
I: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
J: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
K: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
L: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
M: cd344 (homo sapiens) (aka frizzled class receptor 4)
N: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
O: cd147 (homo sapiens) (aka basigin (ok blood group))
P: None of the above. | [H; J; N] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd14]
<Options>: A: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
C: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
D: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
E: cd14 molecule (oryctolagus cuniculus) (aka cd14 molecule)
F: cd141 (homo sapiens) (aka thrombomodulin)
G: cd14 molecule (homo sapiens) (aka cd14 molecule)
H: ifi16 (mus musculus) (aka interferon activated gene 204)
I: cd140a (homo sapiens) (aka platelet derived growth factor receptor alpha)
J: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
K: None of the above. | [A; G] |
<Instruct>: Given the context 'The strongest expression of IFI 16 was in the cells staining brightest for CD14, whereas depletion of CD14+ monocytoid cells from mixed monocytic/granulocytic cultures largely abolished IFI 16-stained cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd14]
<Options>: A: cd142 (homo sapiens) (aka coagulation factor iii, tissue factor)
B: ifi16 (mus musculus) (aka interferon activated gene 204)
C: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
D: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
E: cd14 (homo sapiens) (cd14 molecule (homo sapiens)) (aka cd14 molecule)
F: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
G: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
H: cd141 (homo sapiens) (aka thrombomodulin)
I: cd146 (homo sapiens) (aka melanoma cell adhesion molecule)
J: cd147 (homo sapiens) (aka basigin (ok blood group))
K: None of the above. | [C; E] |
<Instruct>: Given the context 'Furthermore, in eight independent colony-forming assays, the number of IFI 16+ cells correlated closely with the numbers of monocyte precursors identified morphologically (R2 = 0.99), but was unrelated to the numbers of myelocytes, promyelocytes, and metamyelocytes; nor was IFI 16 expressed by erythroid or eosinophil precursors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16]
<Options>: A: ifi16 (mus musculus) (aka interferon activated gene 204)
B: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
C: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
D: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
E: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
F: None of the above. | [E] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
B: cd340 (homo sapiens) (aka erb-b2 receptor tyrosine kinase 2)
C: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
D: cd114 (homo sapiens) (aka colony stimulating factor 3 receptor)
E: cd34 molecule (homo sapiens) (aka cd34 molecule)
F: nectin-4 (homo sapiens) (aka nectin cell adhesion molecule 4)
G: ifi16 (mus musculus) (aka interferon activated gene 204)
H: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
I: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
J: cd34 (gallus gallus) (aka cd34 molecule)
K: None of the above. | [H; E] |
<Instruct>: Given the context 'We conclude that IFI 16 is expressed in CD34+ and monocytoid daughter cells, but is rapidly and markedly down-regulated at the corresponding stages of polymorphonuclear and erythroid development.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16; cd34]
<Options>: A: ifi16 (homo sapiens) (aka interferon gamma inducible protein 16)
B: glyi-16 (glycine max) (aka putative lactoylglutathione lyase)
C: cd34 (gallus gallus) (aka cd34 molecule)
D: cd34 (sus scrofa) (aka cd34 molecule)
E: cd344 (homo sapiens) (aka frizzled class receptor 4)
F: cd34 (homo sapiens) (cd34 molecule (homo sapiens)) (aka cd34 molecule)
G: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
H: fat4 (homo sapiens) (aka fat atypical cadherin 4)
I: ifi-6-1616 (homo sapiens) (aka interferon alpha inducible protein 6)
J: ifi17 (homo sapiens) (aka interferon induced transmembrane protein 1)
K: None of the above. | [A; F] |
<Instruct>: Given the context 'This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ifi 16]
<Options>: A: ifi16 (sus scrofa) (aka myeloid cell nuclear differentiation antigen-like protein)
B: interferon gamma inducible protein 16 (homo sapiens) (aka interferon gamma inducible protein 16)
C: translation machinery associated 16 homolog (xenopus tropicalis) (aka translation machinery associated 16 homolog)
D: ifi15 (homo sapiens) (aka isg15 ubiquitin like modifier)
E: ifi6 (homo sapiens) (aka interferon alpha inducible protein 6)
F: None of the above. | [B] |
<Instruct>: Given the context 'A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
F: None of the above. | [B] |
<Instruct>: Given the context 'A novel candidate oncogene, MCT-1, is involved in cell cycle progression.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
B: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
C: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
D: slc16a1 (homo sapiens) (aka solute carrier family 16 member 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'We termed this novel gene with multiple copies in a T-cell malignancy as MCT-1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
E: mct (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'MCT-1 was localized to the long arm of chromosome Xq22-24 by flourescence in situ hybridization analysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: mct (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
B: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
C: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'Although there was no significant homology at the primary sequence level, there was a limited degree of amino acid homology with a domain of cyclin H that appears to specify protein-protein complexes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [cyclin h]
<Options>: A: ccng (homo sapiens) (aka cyclin g1)
B: ccnh (homo sapiens) (aka cyclin h)
C: cyclin c (homo sapiens) (aka cyclin c)
D: cyclin h (gallus gallus) (aka cyclin h)
E: cyclin p (homo sapiens) (aka cyclin p)
F: None of the above. | [B] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: cyclin p (homo sapiens) (aka cyclin p)
B: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
C: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
D: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: cyclin h (gallus gallus) (aka cyclin h)
G: ccnc (homo sapiens) (aka cyclin c)
H: cyclin g1 (homo sapiens) (aka cyclin g1)
I: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
J: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
K: None of the above. | [J; D] |
<Instruct>: Given the context 'This relationship between MCT-1 and cyclin H implied a potential role for MCT-1 in cell cycle regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: cyclin h (gallus gallus) (aka cyclin h)
B: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
C: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
D: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
E: ccng (homo sapiens) (aka cyclin g1)
F: cyclin p (homo sapiens) (aka cyclin p)
G: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
H: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
I: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
J: ccnc (homo sapiens) (aka cyclin c)
K: None of the above. | [I; H] |
<Instruct>: Given the context 'Overexpression of MCT-1 increased the proliferative rate of cells by decreasing the length of the G1 phase without a reciprocal increase in the S and G2-M phases.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a2 (homo sapiens) (aka solute carrier family 16 member 2)
B: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
C: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
D: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
E: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Therefore, we investigated the transforming ability of MCT-1 overexpression using soft agar growth assays and demonstrated that only MCT-1-overexpressing cells were able to establish colonies.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1]
<Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
C: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
D: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
E: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: cyclin p (homo sapiens) (aka cyclin p)
B: cyclin h (gallus gallus) (aka cyclin h)
C: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
D: solute carrier family 16 member 1 (homo sapiens) (aka solute carrier family 16 member 1)
E: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
F: ccng (homo sapiens) (aka cyclin g1)
G: slc16a3 (homo sapiens) (aka solute carrier family 16 member 3)
H: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
I: cyclin h (homo sapiens) (aka cyclin h)
J: cyclin c (homo sapiens) (aka cyclin c)
K: None of the above. | [H; I] |
<Instruct>: Given the context 'Taken together, MCT-1 is a novel candidate oncogene with homology to a protein-protein binding domain of cyclin H.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mct-1; cyclin h]
<Options>: A: slc16a5 (homo sapiens) (aka solute carrier family 16 member 5)
B: cyclin c (homo sapiens) (aka cyclin c)
C: mct1 (homo sapiens) (solute carrier family 16 member 1 (homo sapiens)) (aka solute carrier family 16 member 1)
D: monocarboxylate transporter 1 (bos taurus) (aka monocarboxylate transporter 1)
E: mct-1 (homo sapiens) (aka mcts1 re-initiation and release factor)
F: p37 (homo sapiens) (cyclin h (homo sapiens)) (aka cyclin h)
G: slc16a6 (homo sapiens) (aka solute carrier family 16 member 6)
H: cyclin h (gallus gallus) (aka cyclin h)
I: cyclin g1 (homo sapiens) (aka cyclin g1)
J: cyclin p (homo sapiens) (aka cyclin p)
K: None of the above. | [E; F] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
B: steroid 5 alpha-reductase 3 (homo sapiens) (aka steroid 5 alpha-reductase 3)
C: hydroxysteroid 17-beta dehydrogenase 3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
D: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
E: 2-alpha-hsd (homo sapiens) (aka aldo-keto reductase family 1 member c1)
F: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
G: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
H: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
I: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
J: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
K: None of the above. | [H; H] |
<Instruct>: Given the context 'Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3alpha-hydroxysteroid dehydrogenase; akr1c3]
<Options>: A: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
B: 2-alpha-hsd (homo sapiens) (aka aldo-keto reductase family 1 member c1)
C: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
D: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
E: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
F: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
G: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
H: 3alpha-hsd (xenopus tropicalis) (aka dehydrogenase/reductase (sdr family) member 9)
I: 24-dehydrocholesterol reductase (homo sapiens) (aka 24-dehydrocholesterol reductase)
J: hsd3b1 (homo sapiens) (aka hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)
K: None of the above. | [A; A] |
<Instruct>: Given the context 'Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and are named AKR1C1-AKR1C4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [3alpha-hydroxysteroid dehydrogenase]
<Options>: A: 3alpha-hsd (homo sapiens) (aka dehydrogenase/reductase 9)
B: 2-alpha-hsd (homo sapiens) (aka aldo-keto reductase family 1 member c1)
C: 17-beta-hsd (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 1)
D: 7-dehydrocholesterol reductase (homo sapiens) (aka 7-dehydrocholesterol reductase)
E: hydroxysteroid 17-beta dehydrogenase 3 (homo sapiens) (aka hydroxysteroid 17-beta dehydrogenase 3)
F: None of the above. | [F] |
<Instruct>: Given the context 'The properties of AKR1C3 have not been fully characterized compared to the other isoforms.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
B: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
C: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
D: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
E: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
F: None of the above. | [C] |
<Instruct>: Given the context 'In addition, a cDNA that shows more than 99% homology with AKR1C3 cDNA has been cloned from human myeloblasts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
C: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
E: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
F: None of the above. | [B] |
<Instruct>: Given the context 'In addition, a cDNA that shows more than 99% homology with AKR1C3 cDNA has been cloned from human myeloblasts.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
B: akr1c1 (homo sapiens) (aka aldo-keto reductase family 1 member c1)
C: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
E: None of the above. | [E] |
<Instruct>: Given the context 'The recombinant AKR1C3 prepared by site-directed mutagenesis of DBDH also showed the same properties as the wild-type DBDH.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
B: akr7a3 (homo sapiens) (aka aldo-keto reductase family 7 member a3)
C: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
D: akr1c-pseudo (homo sapiens) (aka aldo-keto reductase family 1 member c2)
E: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
F: None of the above. | [A] |
<Instruct>: Given the context 'Analyses of expression of mRNAs for DBDH and AKR1C3 by reverse transcription-PCR indicated that only one mRNA species for DBDH is expressed in 33 human specimens of liver, kidney, lung, brain, heart, spleen, adrenal gland, small intestine, placenta, prostate, and testis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: akr1c3 (rattus norvegicus) (aka aldo-keto reductase family 1, member c3)
C: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
D: akr1b3 (mus musculus) (aka aldo-keto reductase family 1 member b)
E: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
F: None of the above. | [E] |
<Instruct>: Given the context 'These results suggest that AKR1C3 acts as prostaglandin D2 11-ketoreductase, and that its principal gene in the human has a coding region represented by DBDH cDNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [akr1c3]
<Options>: A: akr1c3 (sus scrofa) (aka aldo-keto reductase family 1 member c3)
B: akr1b1 (homo sapiens) (aka aldo-keto reductase family 1 member b)
C: akr1c2 (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: akr1c3 (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: akr6a3 (homo sapiens) (aka potassium voltage-gated channel subfamily a regulatory beta subunit 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'In this study, we have identified a previously unclassified aldoketoreductase family member (termed HAKR e) that is expressed in HL60 cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hakr e]
<Options>: A: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
B: klkr (homo sapiens) (aka kallikrein 1)
C: hakrd (homo sapiens) (aka aldo-keto reductase family 1 member c2)
D: hakre (homo sapiens) (aka aldo-keto reductase family 1 member c3)
E: hakra (homo sapiens) (aka aldo-keto reductase family 1 member c4)
F: None of the above. | [D] |
<Instruct>: Given the context 'HAKR e is dramatically and transiently up-regulated in HL60 cells within 24 h of exposure to ATRA, further supporting the proposition that a member(s) of this family of enzymes play(s) a role in controlling cell growth and/or differentiation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hakr e]
<Options>: A: hakrd (homo sapiens) (aka aldo-keto reductase family 1 member c2)
B: hakra (homo sapiens) (aka aldo-keto reductase family 1 member c4)
C: hakre (homo sapiens) (aka aldo-keto reductase family 1 member c3)
D: ackr6 (homo sapiens) (aka pitpnm family member 3)
E: ackr2 (homo sapiens) (aka atypical chemokine receptor 2)
F: None of the above. | [C] |
<Instruct>: Given the context 'G protein-coupled receptors such as the receptors for bradykinin are present in low copy numbers in most natural cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [bradykinin]
<Options>: A: bradykinin receptor b2 (homo sapiens) (aka bradykinin receptor b2)
B: bradykinin (xenopus laevis) (bradykinin receptor b2 s homeolog (xenopus laevis)) (aka bradykinin receptor b2 s homeolog)
C: bk (homo sapiens) (aka kininogen 1)
D: kallikrein b1 (bos taurus) (aka kallikrein b1)
E: kininogen 1 (bos taurus) (aka kininogen 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'The B1 receptor failed to undergo ligand-induced phosphorylation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b1 receptor]
<Options>: A: b1ar (homo sapiens) (aka adrenoceptor beta 1)
B: b1r (homo sapiens) (aka bradykinin receptor b1)
C: adhesion g protein-coupled receptor b1 (homo sapiens) (aka adhesion g protein-coupled receptor b1)
D: neuropeptides b and w receptor 1 (bos taurus) (aka neuropeptides b and w receptor 1)
E: bradykinin receptor b1 (bos taurus) (aka bradykinin receptor b1)
F: None of the above. | [B] |
<Instruct>: Given the context 'However the B2 receptor showed selective phosphorylation of a minor 38 kDa band and lack of phosphorylation of a dominant 33 kDa band, indicating that only a fraction of the receptor protein is functionally linked to the kinase pathway.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [b2 receptor]
<Options>: A: adrb2 (homo sapiens) (aka adrenoceptor beta 2)
B: bdkrb2 (homo sapiens) (aka bradykinin receptor b2)
C: bkb1r (homo sapiens) (aka bradykinin receptor b1)
D: blr2 (homo sapiens) (aka c-c motif chemokine receptor 7)
E: bb2r (homo sapiens) (aka gastrin releasing peptide receptor)
F: None of the above. | [B] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
C: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
D: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
E: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
F: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
G: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
H: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
I: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
J: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
K: None of the above. | [E; K] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
D: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
E: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
F: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
G: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
H: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
I: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h member 12b)
B: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
C: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
D: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
E: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
F: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
G: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
H: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
I: mre11a homolog a, double strand break repair nuclease (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
J: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
K: None of the above. | [J; K] |
<Instruct>: Given the context 'The Saccharomyces cerevisiae MRE11 gene plays an important role in meiotic recombination, mitotic DNA repair and telomere maintenance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
C: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
D: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
E: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
F: None of the above. | [F] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
B: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
C: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
D: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
E: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
F: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
G: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
H: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
I: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
J: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
K: None of the above. | [H; K] |
<Instruct>: Given the context 'We present the isolation of hMRE11B cDNA from a human HeLa cell cDNA library as an MRE11 homolog.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
B: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
C: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
D: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
E: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
F: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
G: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
H: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
I: mre11a homolog a, double strand break repair nuclease (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
J: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
K: None of the above. | [C; K] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11; hmre11b]
<Options>: A: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
B: hmnr11 (homo sapiens) (aka reticulon 2)
C: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
D: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
E: msrg-11 (homo sapiens) (aka spermatogenesis associated 17)
F: ccr4-not transcription complex, subunit 11 (mus musculus) (aka ccr4-not transcription complex, subunit 11)
G: pou domain, class 5, transcription factor 1, related sequence 11 (mus musculus) (aka pou domain, class 5, transcription factor 1, related sequence 11)
H: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
I: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
J: None of the above. | [J; H] |
<Instruct>: Given the context 'Compared to the previously identified hMRE11, hMRE11B contains an additional 84bp sequence that results in a 28 amino-acid insertion close to the C-terminus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11; hmre11b]
<Options>: A: msrg-11 (homo sapiens) (aka spermatogenesis associated 17)
B: olfactory receptor family 2 subfamily r member 11 (mus musculus) (aka olfactory receptor family 2 subfamily r member 11)
C: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
D: hmnr11 (homo sapiens) (aka reticulon 2)
E: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
F: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
G: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
H: hbre1 (homo sapiens) (aka ring finger protein 20)
I: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
J: None of the above. | [J; F] |
<Instruct>: Given the context 'The expression pattern of hMRE11B in different tissues shows the presence of two mRNA species of approx.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
C: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
D: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
E: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
F: None of the above. | [A] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
C: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
D: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
E: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
F: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
G: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
H: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
I: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
J: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
K: None of the above. | [F; K] |
<Instruct>: Given the context 'Overexpression of hMRE11B does not complement the alkylation sensitivity of the mre11 null and temperature-sensitive mutant strains.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
D: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
E: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
F: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
G: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
H: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
I: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
J: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
K: None of the above. | [H; K] |
<Instruct>: Given the context 'First, both Northern and Western analyses rule out the lack of hMRE11B transcription and/or translation in yeast.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b]
<Options>: A: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
B: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
C: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
D: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
E: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
F: None of the above. | [A] |
<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
B: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
C: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
D: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
E: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h member 12b)
F: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
G: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
H: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
I: olfactory receptor family 11 subfamily h member 4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
J: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
K: None of the above. | [D; K] |
<Instruct>: Given the context 'Second, we demonstrate that hMre11B, like the yeast Mre11 protein, dimerizes in vivo in a yeast two-hybrid system.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11]
<Options>: A: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
B: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
C: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
D: mre11 double strand break repair nuclease (homo sapiens) (aka mre11 double strand break repair nuclease)
E: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
F: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
G: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
H: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
I: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
J: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
K: None of the above. | [F; K] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; hmre11]
<Options>: A: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
B: hbre1 (homo sapiens) (aka ring finger protein 20)
C: creme9 (homo sapiens) (aka cytokine receptor like factor 3)
D: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
E: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h member 12b)
F: hmnr11 (homo sapiens) (aka reticulon 2)
G: msrg-11 (homo sapiens) (aka spermatogenesis associated 17)
H: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
I: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
J: None of the above. | [H; J] |
<Instruct>: Given the context 'This dimerization requires the C-terminal one-third of hMre11B protein, which includes the 28 amino acids absent in hMre11.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; hmre11]
<Options>: A: msrg-11 (homo sapiens) (aka spermatogenesis associated 17)
B: olfactory receptor family 11 subfamily h member 12b (bos taurus) (aka olfactory receptor family 11 subfamily h member 12b)
C: creme9 (homo sapiens) (aka cytokine receptor like factor 3)
D: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
E: hmnr11 (homo sapiens) (aka reticulon 2)
F: or2r11 (mus musculus) (aka olfactory receptor family 2 subfamily r member 11)
G: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
H: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
I: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
J: None of the above. | [I; J] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
B: rad50 (xenopus laevis) (aka rad50 homolog, double strand break repair protein l homeolog)
C: xrs2 (saccharomyces cerevisiae s288c) (aka xrs2p)
D: xrn2 (saccharomyces cerevisiae s288c) (aka ssrna exonuclease rat1)
E: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
F: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
G: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
H: x-ray repair cross complementing 2 (homo sapiens) (aka x-ray repair cross complementing 2)
I: rad50 double strand break repair protein (homo sapiens) (aka rad50 double strand break repair protein)
J: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
K: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
L: dna repair protein xrcc2-like (xenopus tropicalis) (aka dna repair protein xrcc2-like)
M: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
N: xrp2 (homo sapiens) (aka rp2 activator of arl3 gtpase)
O: rad-50 (drosophila melanogaster) (aka rad50)
P: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
Q: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
R: hsd11b (homo sapiens) (aka hydroxysteroid 11-beta dehydrogenase 1)
S: rad50 (xenopus tropicalis) (aka rad50 homolog, double strand break repair protein)
T: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
U: None of the above. | [J; U; T; C] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
B: mre11 (homo sapiens) (aka mre11 double strand break repair nuclease)
C: mre11 homolog, double strand break repair nuclease (gallus gallus) (aka mre11 homolog, double strand break repair nuclease)
D: rad50 double strand break repair protein (homo sapiens) (aka rad50 double strand break repair protein)
E: rad50 (xenopus tropicalis) (aka rad50 homolog, double strand break repair protein)
F: xrg2 (homo sapiens) (aka xk related x-linked)
G: xrs2p (saccharomyces cerevisiae s288c) (aka xrs2p)
H: rad50 (drosophila melanogaster) (aka rad50)
I: homolog of x-ray repair cross complementing 2 (arabidopsis thaliana) (aka homolog of x-ray repair cross complementing 2 (xrcc2))
J: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
K: or4c11b (mus musculus) (aka olfactory receptor family 4 subfamily c member 11b)
L: x-ray repair cross complementing 2 (homo sapiens) (aka x-ray repair cross complementing 2)
M: mre11 (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
N: mre11 homolog, double strand break repair nuclease (bos taurus) (aka mre11 homolog, double strand break repair nuclease)
O: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
P: rad50 (xenopus laevis) (aka rad50 homolog, double strand break repair protein l homeolog)
Q: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
R: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
S: xrn2 (homo sapiens) (aka 5'-3' exoribonuclease 2)
T: or2h1b (mus musculus) (aka olfactory receptor family 2 subfamily h member 1b)
U: None of the above. | [R; U; Q; G] |
<Instruct>: Given the context 'However, hMre11B does not interact with Mre11, Rad50 and Xrs2.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmre11b; mre11; rad50; xrs2]
<Options>: A: or11h4b (mus musculus) (aka olfactory receptor family 11 subfamily h member 4b)
B: xrn2 (saccharomyces cerevisiae s288c) (aka ssrna exonuclease rat1)
C: olfactory receptor family 52 subfamily e member 19b (mus musculus) (aka olfactory receptor family 52 subfamily e member 19b)
D: mre11 (drosophila melanogaster) (igf-ii mrna-binding protein (drosophila melanogaster)) (aka igf-ii mrna-binding protein)
E: xrs2 (saccharomyces cerevisiae s288c) (aka xrs2p)
F: olfactory receptor family 8 subfamily b member 12b (mus musculus) (aka olfactory receptor family 8 subfamily b member 12b)
G: or9m1b (mus musculus) (aka olfactory receptor family 9 subfamily m member 1b)
H: mre11 (drosophila melanogaster) (meiotic recombination 11 (drosophila melanogaster)) (aka meiotic recombination 11)
I: rad50 (saccharomyces cerevisiae s288c) (aka mrx complex dna-binding subunit)
J: rad50 (xenopus laevis) (aka rad50 homolog, double strand break repair protein l homeolog)
K: xrp2 (homo sapiens) (aka rp2 activator of arl3 gtpase)
L: rad-50 (drosophila melanogaster) (aka rad50)
M: rad50 (xenopus tropicalis) (aka rad50 homolog, double strand break repair protein)
N: mre11 homolog, double strand break repair nuclease (xenopus tropicalis) (aka mre11 homolog, double strand break repair nuclease)
O: mre11 homolog, double strand break repair nuclease (rattus norvegicus) (aka mre11 homolog, double strand break repair nuclease)
P: mre11a homolog a, double strand break repair nuclease (mus musculus) (aka mre11a homolog a, double strand break repair nuclease)
Q: dna repair protein rad50-like (xenopus tropicalis) (aka dna repair protein rad50-like)
R: hmre11b (homo sapiens) (aka mre11 homolog, double strand break repair nuclease pseudogene 1)
S: xrn2 (homo sapiens) (aka 5'-3' exoribonuclease 2)
T: x-ray repair cross complementing 2 (drosophila melanogaster) (aka x-ray repair cross complementing 2)
U: None of the above. | [R; U; I; E] |
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