instruction stringlengths 226 748 | input stringlengths 159 2.15k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Using a radiation hybrid panel the identified human gene named TM4SF5 (transmembrane 4 superfamily member 5) was localized to chromosome 17 in the region 17p13.3.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5; transmembrane 4 superfamily member 5]
<Options>: A: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
B: transmembrane 4 superfamily member 5 (mus musculus) (aka transmembrane 4 superfamily member 5)
C: tm4-a (homo sapiens) (aka tetraspanin 3)
D: tm4sf (homo sapiens) (aka tetraspanin 1)
E: tm4sf8 (homo sapiens) (aka tetraspanin 3)
F: tetraspanin 5 (homo sapiens) (aka tetraspanin 5)
G: transmembrane 4 l six family member 4 (homo sapiens) (aka transmembrane 4 l six family member 4)
H: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
I: tm4sf10 (homo sapiens) (aka transmembrane protein 47)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'The cloned TM4SF5 cDNA has a 32bp 5'-untranslated region (UTR), a 591bp open reading frame (ORF) and a 85bp 3'UTR.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily member 5)
B: tm4sf4 (homo sapiens) (aka transmembrane 4 l six family member 4)
C: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
D: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
E: tm4sf8 (homo sapiens) (aka tetraspanin 3)
F: None of the above. | [C] |
<Instruct>: Given the context 'The predicted TM4SF5 protein with 197 amino acids contains three NH2-terminal hydrophobic transmembrane regions, followed by an extracellular hydrophilic domain containing two potential N-linked glycosylation sites and a COOH-terminal hydrophobic transmembrane region.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf (homo sapiens) (aka tetraspanin 1)
B: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily member 5)
C: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
D: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
E: tm4sf3 (homo sapiens) (aka tetraspanin 8)
F: None of the above. | [D] |
<Instruct>: Given the context 'These structural features are shared by the L6 antigen and a number of related cell surface proteins associated with cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l6 antigen]
<Options>: A: l7rn6 (homo sapiens) (aka heat shock protein nuclear import factor hikeshi)
B: l6 (homo sapiens) (transmembrane 4 l six family member 1 (homo sapiens)) (aka transmembrane 4 l six family member 1)
C: lethal (1) l6 (drosophila melanogaster) (aka lethal (1) l6)
D: ribosomal protein l6 pseudogene 6 (homo sapiens) (aka ribosomal protein l6 pseudogene 6)
E: l6 (mus musculus) (transmembrane 4 superfamily member 1 (mus musculus)) (aka transmembrane 4 superfamily member 1)
F: None of the above. | [B] |
<Instruct>: Given the context 'These structural features are shared by the L6 antigen and a number of related cell surface proteins associated with cell growth.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l6 antigen]
<Options>: A: l7rn6 (homo sapiens) (aka heat shock protein nuclear import factor hikeshi)
B: ribosomal protein l6 pseudogene 6 (homo sapiens) (aka ribosomal protein l6 pseudogene 6)
C: lethal (1) l6 (drosophila melanogaster) (aka lethal (1) l6)
D: l6 (mus musculus) (transmembrane 4 superfamily member 1 (mus musculus)) (aka transmembrane 4 superfamily member 1)
E: None of the above. | [E] |
<Instruct>: Given the context 'TM4SF5 was overexpressed in pancreatic cancer tissues as compared to both normal pancreas and chronic pancreatitis tissues, and was detected at high levels in other tumour tissues.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf5 (sus scrofa) (aka transmembrane 4 l six family member 5)
B: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
C: tm4sf5 (mus musculus) (aka transmembrane 4 superfamily member 5)
D: tm4sf3 (homo sapiens) (aka tetraspanin 8)
E: tm4sf4 (homo sapiens) (aka transmembrane 4 l six family member 4)
F: None of the above. | [B] |
<Instruct>: Given the context 'Although the precise function of TM4SF5 remains to be elucidated it may be useful in a clinical setting for tumour diagnosis and/or therapy.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [tm4sf5]
<Options>: A: tm4sf10 (homo sapiens) (aka transmembrane protein 47)
B: tm4sf6 (homo sapiens) (aka tetraspanin 6)
C: tm4sf5 (xenopus tropicalis) (aka transmembrane 4 l six family member 5)
D: tm4sf5 (homo sapiens) (aka transmembrane 4 l six family member 5)
E: tm4sf (homo sapiens) (aka tetraspanin 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'This hypothesis is supported by the strong homology to the L6 antigen, which has proved promising in immunological, therapeutic and diagnostic approaches.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [l6 antigen]
<Options>: A: lethal (1) l6 (drosophila melanogaster) (aka lethal (1) l6)
B: l6 (homo sapiens) (transmembrane 4 l six family member 1 (homo sapiens)) (aka transmembrane 4 l six family member 1)
C: l6 (mus musculus) (transmembrane 4 superfamily member 1 (mus musculus)) (aka transmembrane 4 superfamily member 1)
D: l6 (homo sapiens) (ribosomal protein l6 (homo sapiens)) (aka ribosomal protein l6)
E: ribosomal protein l6 pseudogene 6 (homo sapiens) (aka ribosomal protein l6 pseudogene 6)
F: None of the above. | [B] |
<Instruct>: Given the context 'Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4).
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal protein l14]
<Options>: A: ribosomal protein l14 pseudogene (homo sapiens) (aka ribosomal protein l14 pseudogene)
B: ribosomal protein l14 (homo sapiens) (aka ribosomal protein l14)
C: l14 (drosophila melanogaster) (ribosomal protein l14 (drosophila melanogaster)) (aka ribosomal protein l14)
D: 60s ribosomal protein l14-like (homo sapiens) (aka 60s ribosomal protein l14-like)
E: ribosomal protein l14 (mus musculus) (aka ribosomal protein l14)
F: None of the above. | [B] |
<Instruct>: Given the context 'A cDNA encoding human 60S ribosomal subunit protein L14 (hRL14) was isolated from a human immortal endothelial cell line, t-HUE4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal subunit protein l14; hrl14]
<Options>: A: ribosomal protein l14 (mus musculus) (aka ribosomal protein l14)
B: ribosomal protein l14 pseudogene (homo sapiens) (aka ribosomal protein l14 pseudogene)
C: rpl14 (homo sapiens) (aka ribosomal protein l14)
D: mitochondrial ribosomal protein l14 (homo sapiens) (aka mitochondrial ribosomal protein l14)
E: arl14 (homo sapiens) (aka arf like gtpase 14)
F: rpml14 (homo sapiens) (aka mitochondrial ribosomal protein l2)
G: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
H: hmettl14 (homo sapiens) (aka methyltransferase 14, n6-adenosine-methyltransferase non-catalytic subunit)
I: 60s ribosomal protein l14-like (homo sapiens) (aka 60s ribosomal protein l14-like)
J: None of the above. | [C; C] |
<Instruct>: Given the context 'A cDNA encoding human 60S ribosomal subunit protein L14 (hRL14) was isolated from a human immortal endothelial cell line, t-HUE4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ribosomal subunit protein l14; hrl14]
<Options>: A: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
B: rpml14 (homo sapiens) (aka mitochondrial ribosomal protein l2)
C: 60s ribosomal protein l14-like (homo sapiens) (aka 60s ribosomal protein l14-like)
D: l14 (homo sapiens) (ribosomal protein l14 (homo sapiens)) (aka ribosomal protein l14)
E: mitochondrial ribosomal protein l14 (homo sapiens) (aka mitochondrial ribosomal protein l14)
F: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
G: bcl2l14 (homo sapiens) (aka bcl2 like 14)
H: l14 (drosophila melanogaster) (ribosomal protein l14 (drosophila melanogaster)) (aka ribosomal protein l14)
I: ribosomal protein l14 pseudogene (homo sapiens) (aka ribosomal protein l14 pseudogene)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'A significant identity for hRL14 was observed with rat RL14 (85% identity), with exception of COOH-terminal region, but not with any eukaryote amino acid sequences so far deposited to database.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrl14; rl14]
<Options>: A: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
B: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
C: rab14, member ras oncogene family l homeolog (xenopus laevis) (aka rab14, member ras oncogene family l homeolog)
D: protein lurp-one-related 14 (glycine max) (aka protein lurp-one-related 14)
E: hmettl14 (homo sapiens) (aka methyltransferase 14, n6-adenosine-methyltransferase non-catalytic subunit)
F: ribosomal rna-processing protein 14-c-like (glycine max) (aka ribosomal rna-processing protein 14-c-like)
G: ribosomal protein l24-like (drosophila melanogaster) (aka ribosomal protein l24-like)
H: cluster homolog of immunoglobin like receptor like 14 (gallus gallus) (aka cluster homolog of immunoglobin like receptor like 14)
I: rpml14 (homo sapiens) (aka mitochondrial ribosomal protein l2)
J: rl14 (homo sapiens) (aka ribosomal protein l14)
K: None of the above. | [J; K] |
<Instruct>: Given the context 'A significant identity for hRL14 was observed with rat RL14 (85% identity), with exception of COOH-terminal region, but not with any eukaryote amino acid sequences so far deposited to database.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrl14; rl14]
<Options>: A: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
B: hmettl14 (homo sapiens) (aka methyltransferase 14, n6-adenosine-methyltransferase non-catalytic subunit)
C: ribosomal protein l24-like (drosophila melanogaster) (aka ribosomal protein l24-like)
D: ribosomal rna-processing protein 14-c-like (glycine max) (aka ribosomal rna-processing protein 14-c-like)
E: cluster homolog of immunoglobin like receptor like 14 (gallus gallus) (aka cluster homolog of immunoglobin like receptor like 14)
F: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
G: rab14, member ras oncogene family l homeolog (xenopus laevis) (aka rab14, member ras oncogene family l homeolog)
H: rpml14 (homo sapiens) (aka mitochondrial ribosomal protein l2)
I: protein lurp-one-related 14 (glycine max) (aka protein lurp-one-related 14)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'A significant identity for hRL14 was observed with rat RL14 (85% identity), with exception of COOH-terminal region, but not with any eukaryote amino acid sequences so far deposited to database.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrl14; rl14]
<Options>: A: bcl2l14 (homo sapiens) (aka bcl2 like 14)
B: rl14 (homo sapiens) (aka ribosomal protein l14)
C: hrl14 (homo sapiens) (aka ribosomal protein l14)
D: hmettl14 (homo sapiens) (aka methyltransferase 14, n6-adenosine-methyltransferase non-catalytic subunit)
E: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
F: rpl14 (drosophila melanogaster) (aka ribosomal protein l14)
G: arl14 (homo sapiens) (aka arf like gtpase 14)
H: cluster homolog of immunoglobin like receptor like 14 (gallus gallus) (aka cluster homolog of immunoglobin like receptor like 14)
I: ribosomal rna-processing protein 14-c-like (glycine max) (aka ribosomal rna-processing protein 14-c-like)
J: protein lurp-one-related 14 (glycine max) (aka protein lurp-one-related 14)
K: None of the above. | [C; K] |
<Instruct>: Given the context 'The typical features of ribosomal proteins were observed in hRL14, as seen in nuclear targeting sequences necessary for the transport from cytoplasm to nucleolus, a bZIP like (basic region-leucine zipper) element for the binding to rRNA, and the internal repeat sequences; the pentapeptide QKA(A/S)X.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hrl14]
<Options>: A: ribosomal protein l24-like (drosophila melanogaster) (aka ribosomal protein l24-like)
B: hrl14 (homo sapiens) (aka ribosomal protein l14)
C: arl14 (homo sapiens) (aka arf like gtpase 14)
D: hmgb1l14 (homo sapiens) (aka high mobility group box 1 pseudogene 14)
E: bcl2l14 (homo sapiens) (aka bcl2 like 14)
F: None of the above. | [B] |
<Instruct>: Given the context 'The COOH-terminal region of the transcripts contained fifteen triplet repeats (GCT; alanine) at nucleotide 465 to 509, which is significantly expanded compared to the rat RL14.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [rl14]
<Options>: A: protein lurp-one-related 14 (glycine max) (aka protein lurp-one-related 14)
B: rab14, member ras oncogene family l homeolog (xenopus laevis) (aka rab14, member ras oncogene family l homeolog)
C: rpl14l (homo sapiens) (aka ribosomal protein l14 pseudogene 1)
D: cluster homolog of immunoglobin like receptor like 14 (gallus gallus) (aka cluster homolog of immunoglobin like receptor like 14)
E: rpl14 (homo sapiens) (aka ribosomal protein l14)
F: None of the above. | [F] |
<Instruct>: Given the context 'Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
D-Dopachrome tautomerase converts 2-carboxy-2,3-dihydroindole-5,6-quinone (D-dopachrome) into 5,6-dihydroxyindole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
B: d-dopachrome tautomerase-like (homo sapiens) (aka d-dopachrome tautomerase-like)
C: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
D: d-dopachrome tautomerase like (homo sapiens) (aka d-dopachrome tautomerase like)
E: d-dopachrome tautomerase (mus musculus) (aka d-dopachrome tautomerase)
F: None of the above. | [A] |
<Instruct>: Given the context 'This protein has an amino acid sequence that is highly homologous with that of macrophage migration inhibitory factor (MIF), which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage migration inhibitory factor; mif]
<Options>: A: mif1 (homo sapiens) (aka homocysteine inducible er protein with ubiquitin like domain 1)
B: macrophage migration inhibitory factor (xenopus tropicalis) (aka macrophage migration inhibitory factor)
C: migration and invasion inhibitory protein (mus musculus) (aka migration and invasion inhibitory protein)
D: macrophage migration inhibitory factor (glycosylation-inhibiting factor) (mus musculus) (aka macrophage migration inhibitory factor (glycosylation-inhibiting factor))
E: macrophage migration inhibitory factor (caenorhabditis elegans) (aka macrophage migration inhibitory factor)
F: macrophage migration inhibitory factor (homo sapiens) (aka macrophage migration inhibitory factor)
G: migration and invasion inhibitory protein (homo sapiens) (aka migration and invasion inhibitory protein)
H: macrophage migration inhibitory factor (bos taurus) (aka macrophage migration inhibitory factor)
I: None of the above. | [F; F] |
<Instruct>: Given the context 'This protein has an amino acid sequence that is highly homologous with that of macrophage migration inhibitory factor (MIF), which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [macrophage migration inhibitory factor; mif]
<Options>: A: macrophage migration inhibitory factor (xenopus tropicalis) (aka macrophage migration inhibitory factor)
B: migration and invasion inhibitory protein (mus musculus) (aka migration and invasion inhibitory protein)
C: mif (mus musculus) (aka macrophage migration inhibitory factor (glycosylation-inhibiting factor))
D: migration and invasion inhibitory protein (homo sapiens) (aka migration and invasion inhibitory protein)
E: macrophage migration inhibitory factor (bos taurus) (aka macrophage migration inhibitory factor)
F: macrophage migration inhibitory factor (caenorhabditis elegans) (aka macrophage migration inhibitory factor)
G: mif-2 (homo sapiens) (aka d-dopachrome tautomerase)
H: gif (homo sapiens) (macrophage migration inhibitory factor (homo sapiens)) (aka macrophage migration inhibitory factor)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'We isolated and sequenced a 566 bp-long cDNA encoding human D-dopachrome tautomerase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
B: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
C: d-dopachrome tautomerase (bos taurus) (aka d-dopachrome tautomerase)
D: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
E: d-dopachrome tautomerase like (homo sapiens) (aka d-dopachrome tautomerase like)
F: None of the above. | [D] |
<Instruct>: Given the context 'We isolated and sequenced a 566 bp-long cDNA encoding human D-dopachrome tautomerase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
B: d-dopachrome tautomerase (bos taurus) (aka d-dopachrome tautomerase)
C: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
D: d-dopachrome tautomerase like (homo sapiens) (aka d-dopachrome tautomerase like)
E: None of the above. | [E] |
<Instruct>: Given the context 'Northern blot analysis demonstrated that mRNA of D-dopachrome tautomerase is expressed in a large amount in the liver, and to lesser extent in other organs, including the heart, lung and pancreas.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: dopachrome tautomerase (bos taurus) (aka dopachrome tautomerase)
B: d-dopachrome tautomerase like (homo sapiens) (aka d-dopachrome tautomerase like)
C: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
D: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
E: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
F: None of the above. | [E] |
<Instruct>: Given the context 'After purification of D-dopachrome tautomerase expressed in E. coli, we confirmed that the recombinant protein catalyzes the conversion of D-dopachrome to 5,6-dihydroxyindole.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: dopachrome tautomerase (xenopus tropicalis) (aka dopachrome tautomerase)
B: dopachrome tautomerase (homo sapiens) (aka dopachrome tautomerase)
C: d-dopachrome tautomerase like (homo sapiens) (aka d-dopachrome tautomerase like)
D: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
E: d-dopachrome tautomerase (mus musculus) (aka d-dopachrome tautomerase)
F: None of the above. | [D] |
<Instruct>: Given the context 'Although the precise pathophysiological function of D-dopachrome tautomerase remains to be elucidated, the present results could contribute to further understanding of isomerase activity in relation to the immune response.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [d-dopachrome tautomerase]
<Options>: A: d-dopachrome tautomerase (bos taurus) (aka d-dopachrome tautomerase)
B: d-dopachrome tautomerase (homo sapiens) (aka d-dopachrome tautomerase)
C: d-dopachrome tautomerase (xenopus tropicalis) (aka d-dopachrome tautomerase)
D: dopachrome tautomerase (bos taurus) (aka dopachrome tautomerase)
E: d-dopachrome tautomerase (mus musculus) (aka d-dopachrome tautomerase)
F: None of the above. | [B] |
<Instruct>: Given the context 'Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
B: pax-4 (xenopus tropicalis) (aka paired box 4)
C: pax4 (mus musculus) (aka paired box 4)
D: paired box 4 (bos taurus) (aka paired box 4)
E: paired box 4 (gallus gallus) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Recent genetic studies have suggested that PAX4, a member of the paired box (PAX) gene family, is involved in the mechanism regulating the fate of pancreatic islet endocrine progenitor cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: pax4 (homo sapiens) (aka paired box 4)
B: paired box 4 (gallus gallus) (aka paired box 4)
C: pax-4 (xenopus tropicalis) (aka paired box 4)
D: pax4 (mus musculus) (aka paired box 4)
E: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
F: None of the above. | [D] |
<Instruct>: Given the context 'Murine PAX4 was originally identified by genomic screening and, to date, only a partial sequence of PAX4 has been reported.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
B: paired box 4 (xenopus tropicalis) (aka paired box 4)
C: paired box 4 (homo sapiens) (aka paired box 4)
D: paired box 4 (bos taurus) (aka paired box 4)
E: pax4 (mus musculus) (aka paired box 4)
F: None of the above. | [E] |
<Instruct>: Given the context 'In this study, we cloned the full-length cDNA of mouse PAX4 by RACE (rapid amplification of cDNA ends) using RNA from MIN6 cells, a mouse insulinoma cell line.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box 4 (bos taurus) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: pax4 (mus musculus) (aka paired box 4)
D: paired box 4 (xenopus tropicalis) (aka paired box 4)
E: pax4 (homo sapiens) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'The deduced mouse PAX4 protein was 349 amino acids and had the predicted molecular weight of 38 kDa.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: pax4 (mus musculus) (aka paired box 4)
B: pax4 (xenopus tropicalis) (aka paired box 4)
C: paired box 4 (gallus gallus) (aka paired box 4)
D: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
E: paired box 4 (bos taurus) (aka paired box 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'Two DNA binding motifs, a 128-amino acid paired domain and a 61-amino acid paired-type homeodomain exhibit the highest amino acid homology with PAX6 (71.2%, 65.0%, respectively), another member of the PAX gene family.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax6]
<Options>: A: pax6 (xenopus laevis) (paired box 6 s homeolog (xenopus laevis)) (aka paired box 6 s homeolog)
B: pax6.2 (xenopus laevis) (paired box 6 like s homeolog (xenopus laevis)) (aka paired box 6 like s homeolog)
C: paired box 6 (homo sapiens) (aka paired box 6)
D: pax6/eye (drosophila melanogaster) (aka eyeless)
E: paired box protein 6 homolog (gallus gallus) (aka paired box protein 6 homolog)
F: None of the above. | [C] |
<Instruct>: Given the context 'However, the sequence of the C-terminal segment of PAX4 diverged and showed no significant homology with any other known PAX genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: pax4 (mus musculus) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: paired box 4 (bos taurus) (aka paired box 4)
D: paired box 4 (gallus gallus) (aka paired box 4)
E: pax4 (homo sapiens) (aka paired box 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'However, the sequence of the C-terminal segment of PAX4 diverged and showed no significant homology with any other known PAX genes.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: pax4 (homo sapiens) (aka paired box 4)
B: paired box 4 (gallus gallus) (aka paired box 4)
C: paired box 4 (bos taurus) (aka paired box 4)
D: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
E: None of the above. | [E] |
<Instruct>: Given the context 'As to the genomic DNA, the coding region of the mouse PAX4 gene spanned approximately 5.5 kb and was composed of 10 exons.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box 4 (xenopus tropicalis) (aka paired box 4)
B: paired box 4 (bos taurus) (aka paired box 4)
C: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
D: pax4 (mus musculus) (aka paired box 4)
E: paired box 4 (homo sapiens) (aka paired box 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'In the public DNA database, a human cosmid (g1572c264), which was localized on human chromosome 7q31.3, was found to contain a gene homologous to PAX4.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: pax4 (xenopus tropicalis) (aka paired box 4)
B: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
C: pax-4 (mus musculus) (aka paired box 4)
D: paired box 4 (gallus gallus) (aka paired box 4)
E: pax4 (homo sapiens) (aka paired box 4)
F: None of the above. | [E] |
<Instruct>: Given the context 'The nucleotide and protein sequence homologies between mouse PAX4 and its human homologue were 83.1% and 80.0%, respectively.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box 4 (bos taurus) (aka paired box 4)
B: paired box 4 (xenopus tropicalis) (aka paired box 4)
C: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
D: pax-4 (mus musculus) (aka paired box 4)
E: paired box 4 (gallus gallus) (aka paired box 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
B: actin related protein 5 (homo sapiens) (aka actin related protein 5)
C: actin-related protein arp5 (saccharomyces cerevisiae s288c) (aka actin-related protein arp5)
D: actin-related protein 2/3 complex, subunit 5 (drosophila melanogaster) (aka actin-related protein 2/3 complex, subunit 5)
E: adp-ribosylation factor-like 5 (drosophila melanogaster) (aka adp-ribosylation factor-like 5)
F: paired box 4 (homo sapiens) (aka paired box 4)
G: pax-4 (mus musculus) (aka paired box 4)
H: arf gtpase 5 (homo sapiens) (aka arf gtpase 5)
I: arp5 actin-related protein 5 (mus musculus) (aka arp5 actin-related protein 5)
J: arf-5 (caenorhabditis elegans) (aka adp-ribosylation factor)
K: pax-4 (xenopus tropicalis) (aka paired box 4)
L: paired box 4 (bos taurus) (aka paired box 4)
M: arp5 actin related protein 5 homolog s homeolog (xenopus laevis) (aka arp5 actin related protein 5 homolog s homeolog)
N: arflp5 (homo sapiens) (aka arf like gtpase 5a)
O: adp-ribosyltransferase 5 (homo sapiens) (aka adp-ribosyltransferase 5)
P: None of the above. | [H; H; F] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: arp5 actin related protein 5 homolog s homeolog (xenopus laevis) (aka arp5 actin related protein 5 homolog s homeolog)
B: pax4 (homo sapiens) (aka paired box 4)
C: arl5ap5 (homo sapiens) (aka arl5a pseudogene 5)
D: arf-5 (caenorhabditis elegans) (aka adp-ribosylation factor)
E: actin-related protein 2/3 complex, subunit 5 (drosophila melanogaster) (aka actin-related protein 2/3 complex, subunit 5)
F: adp ribosylation factor 5 (sus scrofa) (aka adp ribosylation factor 5)
G: pax-4 (xenopus tropicalis) (aka paired box 4)
H: actin-related protein arp5 (saccharomyces cerevisiae s288c) (aka actin-related protein arp5)
I: paired box 4 (bos taurus) (aka paired box 4)
J: adp-ribosyltransferase 5 (homo sapiens) (aka adp-ribosyltransferase 5)
K: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
L: paired box 4 (gallus gallus) (aka paired box 4)
M: arp5 actin-related protein 5 (mus musculus) (aka arp5 actin-related protein 5)
N: arf5 (homo sapiens) (aka arf gtpase 5)
O: arflp5 (homo sapiens) (aka arf like gtpase 5a)
P: None of the above. | [N; N; B] |
<Instruct>: Given the context 'Interestingly, the ARP5 (ADP-ribosylation factor 5) gene was also found in the same cosmid g1572c264, suggesting the ARP5 gene to be adjacent to the human PAX4 homologue.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [arp5; adp-ribosylation factor 5; pax4]
<Options>: A: arp5 actin-related protein 5 (mus musculus) (aka arp5 actin-related protein 5)
B: pax4 (mus musculus) (aka paired box 4)
C: paired box 4 (gallus gallus) (aka paired box 4)
D: adp-ribosylation factor-like 5 (drosophila melanogaster) (aka adp-ribosylation factor-like 5)
E: arf5 (homo sapiens) (aka arf gtpase 5)
F: arp5 actin-related protein 5 homolog (gallus gallus) (aka arp5 actin-related protein 5 homolog)
G: arflp5 (homo sapiens) (aka arf like gtpase 5a)
H: pax-4 (xenopus tropicalis) (aka paired box 4)
I: pax4 (homo sapiens) (aka paired box 4)
J: arp5 actin related protein 5 homolog s homeolog (xenopus laevis) (aka arp5 actin related protein 5 homolog s homeolog)
K: adp ribosylation factor 5 (sus scrofa) (aka adp ribosylation factor 5)
L: adp-ribosyltransferase 5 (homo sapiens) (aka adp-ribosyltransferase 5)
M: arp5 (homo sapiens) (actin related protein 5 (homo sapiens)) (aka actin related protein 5)
N: actin-related protein 2/3 complex, subunit 5 (drosophila melanogaster) (aka actin-related protein 2/3 complex, subunit 5)
O: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
P: None of the above. | [E; E; I] |
<Instruct>: Given the context 'The results of this study, i.e. isolation of the full-length cDNA sequence of PAX4 and identification of the homologous human gene, will facilitate further functional and genetic studies of the PAX4 gene.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [pax4]
<Options>: A: paired box 4 (gallus gallus) (aka paired box 4)
B: pax4 (xenopus tropicalis) (aka paired box 4)
C: pax4 (mus musculus) (aka paired box 4)
D: paired box protein pax-4 (xenopus laevis) (aka paired box protein pax-4)
E: paired box 4 (homo sapiens) (aka paired box 4)
F: None of the above. | [C] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
B: gstap3 (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
C: gstm4 (homo sapiens) (aka glutathione s-transferase mu 4)
D: gst-3 (homo sapiens) (aka microsomal glutathione s-transferase 3)
E: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
F: gsta3-3 (homo sapiens) (aka glutathione s-transferase alpha 3)
G: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
H: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
I: gsta4 (sus scrofa) (aka glutathione s-transferase alpha 4)
J: gsta4 (gallus gallus) (aka glutathione s-transferase alpha 4)
K: gstm3p (homo sapiens) (aka glutathione s-transferase mu 3 pseudogene 1)
L: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
M: None of the above. | [F; E; E] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
B: gstap4 (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
C: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
D: gsta4 (sus scrofa) (aka glutathione s-transferase alpha 4)
E: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
F: gsta3l (gallus gallus) (aka glutathione s-transferase alpha 4)
G: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
H: gsta3-3 (homo sapiens) (aka glutathione s-transferase alpha 3)
I: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
J: gsta3 (gallus gallus) (aka glutathione s-transferase alpha 3)
K: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
L: gsta4 (homo sapiens) (aka glutathione s-transferase alpha 4)
M: gst-iii (homo sapiens) (aka microsomal glutathione s-transferase 3)
N: None of the above. | [H; L; L] |
<Instruct>: Given the context 'Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3; gsta4; gsta4-4]
<Options>: A: gsta4 (gallus gallus) (aka glutathione s-transferase alpha 4)
B: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
C: glutathione s-transferase alpha 3 (homo sapiens) (aka glutathione s-transferase alpha 3)
D: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
E: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
F: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
G: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
H: gsta4 (sus scrofa) (aka glutathione s-transferase alpha 4)
I: gstm4 (homo sapiens) (aka glutathione s-transferase mu 4)
J: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
K: gstap3 (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
L: gsta3 (gallus gallus) (aka glutathione s-transferase alpha 3)
M: gst-iii (homo sapiens) (aka microsomal glutathione s-transferase 3)
N: gstm4-4 (homo sapiens) (aka glutathione s-transferase mu 4)
O: None of the above. | [C; E; E] |
<Instruct>: Given the context 'An incomplete transcript of the previously described GSTA3 gene was identified in a cDNA library derived from 8-9 week placenta.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3]
<Options>: A: gstm3p (homo sapiens) (aka glutathione s-transferase mu 3 pseudogene 1)
B: gstap3 (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
C: gsta3 (gallus gallus) (aka glutathione s-transferase alpha 3)
D: gsta3 (homo sapiens) (aka glutathione s-transferase alpha 3)
E: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'This indicates that the GSTA3 gene is functional and is possibly under specific developmental regulation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta3]
<Options>: A: gst-3 (homo sapiens) (aka microsomal glutathione s-transferase 3)
B: gsta3 (gallus gallus) (aka glutathione s-transferase alpha 3)
C: gsta3 (homo sapiens) (aka glutathione s-transferase alpha 3)
D: gstm3 (homo sapiens) (aka glutathione s-transferase mu 3)
E: gstap3 (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
F: None of the above. | [C] |
<Instruct>: Given the context 'A second cDNA, termed GSTA4, was identified in a brain cDNA library.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4]
<Options>: A: gstap4 (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
B: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
C: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
D: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
E: gstm4-4 (homo sapiens) (aka glutathione s-transferase mu 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'The encoded GSTA4-4 enzyme was expressed in Escherichia coli and was found to be immunologically distinct from GSTA1-1 and to have high activity with alk-2-enals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4-4; gsta1-1]
<Options>: A: gsta1-1 (sus scrofa) (aka glutathione s-transferase alpha 1)
B: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
C: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
D: gstap1 (homo sapiens) (aka glutathione s-transferase alpha 6, pseudogene)
E: gst1-1 (homo sapiens) (aka glutathione s-transferase mu 1)
F: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
G: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
H: gst-1 (homo sapiens) (aka carbohydrate sulfotransferase 1)
I: gsta1 (homo sapiens) (aka glutathione s-transferase alpha 1)
J: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
K: None of the above. | [G; I] |
<Instruct>: Given the context 'The encoded GSTA4-4 enzyme was expressed in Escherichia coli and was found to be immunologically distinct from GSTA1-1 and to have high activity with alk-2-enals.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4-4; gsta1-1]
<Options>: A: gst-1 (homo sapiens) (aka carbohydrate sulfotransferase 1)
B: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
C: gsta11p (homo sapiens) (aka glutathione s-transferase alpha 11, pseudogene)
D: gst1-1 (homo sapiens) (aka glutathione s-transferase mu 1)
E: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
F: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
G: gsta1 (homo sapiens) (aka glutathione s-transferase alpha 1)
H: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
I: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
J: gstap1 (homo sapiens) (aka glutathione s-transferase alpha 6, pseudogene)
K: None of the above. | [B; G] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: glutathione s-transferase gst 8 (glycine max) (aka glutathione s-transferase gst 8)
B: gsta8p (homo sapiens) (aka glutathione s-transferase alpha 8, pseudogene)
C: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
D: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
E: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
F: gstu8 (glycine max) (aka glutathione s-transferase u17-like)
G: gsta5 (homo sapiens) (aka glutathione s-transferase alpha 5)
H: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
I: gsta7p (homo sapiens) (aka glutathione s-transferase alpha 7, pseudogene)
J: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
K: gst-5 (homo sapiens) (aka carbohydrate sulfotransferase 7)
L: gsta4-4 (xenopus laevis) (aka glutathione s-transferase alpha 4 s homeolog)
M: gst5 (homo sapiens) (aka glutathione s-transferase mu 3)
N: gst5.7 (mus musculus) (aka glutathione s-transferase, alpha 4)
O: None of the above. | [J; N; O] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: gst-5 (homo sapiens) (aka carbohydrate sulfotransferase 7)
B: gsta7p (homo sapiens) (aka glutathione s-transferase alpha 7, pseudogene)
C: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
D: gst5.7 (mus musculus) (aka glutathione s-transferase, alpha 4)
E: glutathione s-transferase gst 8 (glycine max) (aka glutathione s-transferase gst 8)
F: gstu8 (glycine max) (aka glutathione s-transferase u17-like)
G: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
H: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
I: gsta4 (homo sapiens) (aka glutathione s-transferase alpha 4)
J: gst5 (homo sapiens) (aka glutathione s-transferase mu 3)
K: gstap5 (homo sapiens) (aka glutathione s-transferase alpha 12, pseudogene)
L: gstf8 (glycine max) (aka glutathione s-transferase f11-like)
M: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
N: None of the above. | [I; D; N] |
<Instruct>: Given the context 'Although GSTA4-4 appears to be functionally similar to the mouse GST5.7 and rat GST8-8 Alpha class enzymes, sequence comparisons and phylogenetic analysis suggest that GSTA4-4 may be a member of a distinct Alpha class subgroup.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [gsta4-4; gst5.7; gst8-8 alpha]
<Options>: A: gsta4-4 (xenopus tropicalis) (aka glutathione s-transferase alpha 4)
B: gstm5-5 (homo sapiens) (aka glutathione s-transferase mu 5)
C: gst4 (homo sapiens) (aka glutathione s-transferase mu 2)
D: gsta4-4 (homo sapiens) (aka glutathione s-transferase alpha 4)
E: gsta4-ps4 (rattus norvegicus) (aka glutathione s-transferase alpha 4, pseudogene 4)
F: gst-5 (homo sapiens) (aka carbohydrate sulfotransferase 7)
G: gstf8 (glycine max) (aka glutathione s-transferase f11-like)
H: gsta8p (homo sapiens) (aka glutathione s-transferase alpha 8, pseudogene)
I: gsta4p (homo sapiens) (aka glutathione s-transferase alpha 9, pseudogene)
J: gstt4 (homo sapiens) (aka glutathione s-transferase theta 4)
K: glutathione s-transferase gst 8 (glycine max) (aka glutathione s-transferase gst 8)
L: gst5.7 (mus musculus) (aka glutathione s-transferase, alpha 4)
M: gsta5 (homo sapiens) (aka glutathione s-transferase alpha 5)
N: gstm5p1 (homo sapiens) (aka glutathione s-transferase mu 5 pseudogene 1)
O: None of the above. | [D; L; O] |
<Instruct>: Given the context 'Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.
', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4]
<Options>: A: actinin-4 (homo sapiens) (aka actinin alpha 4)
B: actn4 (mus musculus) (aka actinin alpha 4)
C: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
D: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
E: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4; actinin-1]
<Options>: A: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
B: actn4 (homo sapiens) (aka actinin alpha 4)
C: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
D: actinin (xenopus laevis) (actinin alpha 1 s homeolog (xenopus laevis)) (aka actinin alpha 1 s homeolog)
E: actn4 (mus musculus) (aka actinin alpha 4)
F: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
G: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
H: actn1 (homo sapiens) (aka actinin alpha 1)
I: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
J: actin-1 (caenorhabditis elegans) (aka actin-1)
K: None of the above. | [B; H] |
<Instruct>: Given the context 'This isoform (designated actinin-4) was concentrated in the cytoplasm where cells were sharply extended and in cells migrating and located at the edge of cell clusters, but was absent from focal adhesion plaques or adherens junctions, where the classic isoform (actinin-1) was concentrated.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4; actinin-1]
<Options>: A: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
B: actinin alpha 3 (homo sapiens) (aka actinin alpha 3)
C: alpha-actinin, sarcomeric (caenorhabditis elegans) (aka alpha-actinin, sarcomeric)
D: actinin (xenopus laevis) (actinin alpha 1 l homeolog (xenopus laevis)) (aka actinin alpha 1 l homeolog)
E: actinin alpha 2 (homo sapiens) (aka actinin alpha 2)
F: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
G: actinin alpha 1 (homo sapiens) (aka actinin alpha 1)
H: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
I: actn4 (mus musculus) (aka actinin alpha 4)
J: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
K: None of the above. | [J; G] |
<Instruct>: Given the context 'Actinin-4 shifted steadily from the cytoplasm to the nucleus upon inhibition of phosphatidylinositol 3 kinase or actin depolymerization.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4]
<Options>: A: actn4 (homo sapiens) (aka actinin alpha 4)
B: actinin alpha 4 (mus musculus) (aka actinin alpha 4)
C: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
D: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
E: actinin alpha 4 (bos taurus) (aka actinin alpha 4)
F: None of the above. | [A] |
<Instruct>: Given the context 'The cytoplasmic localization of actinin-4 was closely associated with an infiltrative histological phenotype and correlated significantly with a poorer prognosis in 61 cases of breast cancer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4]
<Options>: A: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
B: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
C: actinin alpha 4 (xenopus tropicalis) (aka actinin alpha 4)
D: actinin-4 (homo sapiens) (aka actinin alpha 4)
E: actinin alpha 4 (mus musculus) (aka actinin alpha 4)
F: None of the above. | [D] |
<Instruct>: Given the context 'These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [actinin-4]
<Options>: A: actn4.l (xenopus laevis) (actinin alpha 4 s homeolog (xenopus laevis)) (aka actinin alpha 4 s homeolog)
B: actn4 (mus musculus) (aka actinin alpha 4)
C: actinin alpha 4 (homo sapiens) (aka actinin alpha 4)
D: actin;actin-4 (caenorhabditis elegans) (aka actin;actin-4)
E: actn4.l (xenopus laevis) (actinin alpha 4 l homeolog (xenopus laevis)) (aka actinin alpha 4 l homeolog)
F: None of the above. | [C] |
<Instruct>: Given the context 'Considering the well established role of nonclassical HLA-G class I molecules in inhibiting natural killer (NK) cell function, the consequence of abnormal HLA-G expression in malignant cells should be the escape of tumors from immunosurveillance.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hla-g class i]
<Options>: A: major histocompatibility complex, class i, a (homo sapiens) (aka major histocompatibility complex, class i, a)
B: major histocompatibility complex, class i, f (homo sapiens) (aka major histocompatibility complex, class i, f)
C: major histocompatibility complex, class i, c (homo sapiens) (aka major histocompatibility complex, class i, c)
D: mhc-g (homo sapiens) (aka major histocompatibility complex, class i, g)
E: major histocompatibility complex, class i, e (homo sapiens) (aka major histocompatibility complex, class i, e)
F: None of the above. | [D] |
<Instruct>: Given the context 'Our analysis of three melanoma cell lines and ex vivo biopsy demonstrated that (i) IGR and M74 human melanoma cell lines exhibit a high level of HLA-G transcription with differential HLA-G isoform transcription and protein expression patterns, (ii) a higher level of HLA-G transcription ex vivo is detected in a skin melanoma metastasis biopsy compared with a healthy skin fragment from the same individual, and (iii) HLA-G protein isoforms other than membrane-bound HLA-G1 protect IGR from NK lysis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hla-g1]
<Options>: A: hla-z1 (homo sapiens) (aka major histocompatibility complex, class i, z (pseudogene))
B: major histocompatibility complex, class i, c (homo sapiens) (aka major histocompatibility complex, class i, c)
C: major histocompatibility complex, class i, e (homo sapiens) (aka major histocompatibility complex, class i, e)
D: major histocompatibility complex, class i, g (homo sapiens) (aka major histocompatibility complex, class i, g)
E: major histocompatibility complex, class i, a (homo sapiens) (aka major histocompatibility complex, class i, a)
F: None of the above. | [D] |
<Instruct>: Given the context 'We have now cloned and characterized a third member of the synapsin gene family, synapsin III, from human DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii]
<Options>: A: synapsin i (xenopus tropicalis) (aka synapsin i)
B: synapsin i (homo sapiens) (aka synapsin i)
C: synapsin iii (xenopus tropicalis) (aka synapsin iii)
D: synapsin iii (homo sapiens) (aka synapsin iii)
E: sytiii (homo sapiens) (aka synaptotagmin 3)
F: None of the above. | [D] |
<Instruct>: Given the context 'Synapsin III gives rise to at least one protein isoform, designated synapsin IIIa, in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii; synapsin iiia]
<Options>: A: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
B: syn1 (xenopus tropicalis) (synapsin i (xenopus tropicalis)) (aka synapsin i)
C: synapsin iii (homo sapiens) (aka synapsin iii)
D: syniia (xenopus laevis) (synapsin ii s homeolog (xenopus laevis)) (aka synapsin ii s homeolog)
E: synapsin ii (homo sapiens) (aka synapsin ii)
F: synapsin ii (xenopus tropicalis) (aka synapsin ii)
G: synapsin i (homo sapiens) (aka synapsin i)
H: synapsin i (xenopus tropicalis) (aka synapsin i)
I: None of the above. | [C; C] |
<Instruct>: Given the context 'Synapsin III gives rise to at least one protein isoform, designated synapsin IIIa, in several mammalian species.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii; synapsin iiia]
<Options>: A: synapsin ii (xenopus tropicalis) (aka synapsin ii)
B: synapsin iii (homo sapiens) (aka synapsin iii)
C: synapsin i (homo sapiens) (aka synapsin i)
D: synapsin iii (sus scrofa) (aka synapsin iii)
E: synapsin iii (xenopus tropicalis) (aka synapsin iii)
F: synapsin-1 (homo sapiens) (aka synapsin-1)
G: synii (xenopus laevis) (synapsin ii s homeolog (xenopus laevis)) (aka synapsin ii s homeolog)
H: None of the above. | [B; B] |
<Instruct>: Given the context 'Synapsin IIIa is associated with synaptic vesicles, and its expression appears to be neuron-specific.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iiia]
<Options>: A: synapsin ii (xenopus tropicalis) (aka synapsin ii)
B: synapsin i (xenopus tropicalis) (aka synapsin i)
C: synapsin iii (sus scrofa) (aka synapsin iii)
D: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
E: synapsin iii (homo sapiens) (aka synapsin iii)
F: None of the above. | [E] |
<Instruct>: Given the context 'The primary structure of synapsin IIIa conforms to the domain model previously described for the synapsin family, with domains A, C, and E exhibiting the highest degree of conservation.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iiia]
<Options>: A: syniia (xenopus laevis) (synapsin ii s homeolog (xenopus laevis)) (aka synapsin ii s homeolog)
B: synapsin iii (homo sapiens) (aka synapsin iii)
C: synapsin iii (sus scrofa) (aka synapsin iii)
D: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
E: synapsin ii (xenopus tropicalis) (aka synapsin ii)
F: None of the above. | [B] |
<Instruct>: Given the context 'Synapsin IIIa contains a novel domain, termed domain J, located between domains C and E. The similarities among synapsins I, II, and III in domain organization, neuron-specific expression, and subcellular localization suggest a possible role for synapsin III in the regulation of neurotransmitter release and synaptogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iiia; synapsin iii]
<Options>: A: synapsin-1 (homo sapiens) (aka synapsin-1)
B: synapsin i (homo sapiens) (aka synapsin i)
C: sytiii (homo sapiens) (aka synaptotagmin 3)
D: synapsin iii (homo sapiens) (aka synapsin iii)
E: synapsin ii (xenopus tropicalis) (aka synapsin ii)
F: synapsin iii (xenopus tropicalis) (aka synapsin iii)
G: synii (xenopus laevis) (synapsin ii s homeolog (xenopus laevis)) (aka synapsin ii s homeolog)
H: None of the above. | [D; D] |
<Instruct>: Given the context 'Synapsin IIIa contains a novel domain, termed domain J, located between domains C and E. The similarities among synapsins I, II, and III in domain organization, neuron-specific expression, and subcellular localization suggest a possible role for synapsin III in the regulation of neurotransmitter release and synaptogenesis.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iiia; synapsin iii]
<Options>: A: synapsin iii (xenopus tropicalis) (aka synapsin iii)
B: synapsin i (homo sapiens) (aka synapsin i)
C: sytiii (homo sapiens) (aka synaptotagmin 3)
D: synapsin i (xenopus tropicalis) (aka synapsin i)
E: synapsin iii (mus musculus) (aka synapsin iii)
F: synapsin iii (sus scrofa) (aka synapsin iii)
G: synapsin (xenopus laevis) (synapsin i s homeolog (xenopus laevis)) (aka synapsin i s homeolog)
H: synapsin iii (homo sapiens) (aka synapsin iii)
I: synii (xenopus laevis) (synapsin ii s homeolog (xenopus laevis)) (aka synapsin ii s homeolog)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'The human synapsin III gene is located on chromosome 22q12-13, which has been identified as a possible schizophrenia susceptibility locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii]
<Options>: A: synapsin iii (homo sapiens) (aka synapsin iii)
B: synapsin iii (mus musculus) (aka synapsin iii)
C: synapsin i (homo sapiens) (aka synapsin i)
D: synapsin ii (xenopus tropicalis) (aka synapsin ii)
E: sytiii (homo sapiens) (aka synaptotagmin 3)
F: None of the above. | [A] |
<Instruct>: Given the context 'The human synapsin III gene is located on chromosome 22q12-13, which has been identified as a possible schizophrenia susceptibility locus.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii]
<Options>: A: synapsin ii (xenopus tropicalis) (aka synapsin ii)
B: synapsin i (homo sapiens) (aka synapsin i)
C: sytiii (homo sapiens) (aka synaptotagmin 3)
D: synapsin iii (mus musculus) (aka synapsin iii)
E: None of the above. | [E] |
<Instruct>: Given the context 'On the basis of this localization and the well established neurobiological roles of the synapsins, synapsin III represents a candidate gene for schizophrenia.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [synapsin iii]
<Options>: A: synapsin ii (homo sapiens) (aka synapsin ii)
B: synapsin-1 (homo sapiens) (aka synapsin-1)
C: synapsin i (xenopus tropicalis) (aka synapsin i)
D: synapsin iii (sus scrofa) (aka synapsin iii)
E: synapsin iii (homo sapiens) (aka synapsin iii)
F: None of the above. | [E] |
<Instruct>: Given the context 'In this study we investigated the effects of eight muscarinic ligands on the rate constants for endocytosis and recycling of m3 muscarinic acetylcholine receptors in human SH-SY5Y neuroblastoma cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [m3 muscarinic acetylcholine receptors]
<Options>: A: cholinergic receptor, muscarinic 3, cardiac (mus musculus) (aka cholinergic receptor, muscarinic 3, cardiac)
B: chrm3 (homo sapiens) (aka cholinergic receptor muscarinic 3)
C: m3 (mus musculus) (relaxin 3 (mus musculus)) (aka relaxin 3)
D: chrm3 (gallus gallus) (aka cholinergic receptor muscarinic 3)
E: cholinergic receptor, muscarinic 3 (xenopus tropicalis) (aka cholinergic receptor, muscarinic 3)
F: None of the above. | [B] |
<Instruct>: Given the context 'Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.
DNA ligase IV in a complex with XRCC4 is responsible for DNA end-joining in repair of DNA double-strand breaks (DSB) and V(D)J recombination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna ligase iv; xrcc4]
<Options>: A: xrcc4 (homo sapiens) (aka x-ray repair cross complementing 4)
B: ligase iv (drosophila melanogaster) (aka dna ligase 4)
C: xrcc7 (homo sapiens) (aka protein kinase, dna-activated, catalytic subunit)
D: dna ligase 4 (oryctolagus cuniculus) (aka dna ligase 4)
E: homolog of human dna ligase iv-binding protein xrcc4 (arabidopsis thaliana) (aka dna ligase iv-binding protein)
F: xrcc4.l (xenopus laevis) (aka x-ray repair complementing defective repair in chinese hamster cells 4 l homeolog)
G: dna ligase 4 (homo sapiens) (aka dna ligase 4)
H: ligase iv, dna, atp-dependent (danio rerio) (aka ligase iv, dna, atp-dependent)
I: dna ligase 4-like (xenopus laevis) (aka dna ligase 4-like)
J: xrcc6 (homo sapiens) (aka x-ray repair cross complementing 6)
K: None of the above. | [G; A] |
<Instruct>: Given the context 'Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.
DNA ligase IV in a complex with XRCC4 is responsible for DNA end-joining in repair of DNA double-strand breaks (DSB) and V(D)J recombination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna ligase iv; xrcc4]
<Options>: A: xrcc4 (homo sapiens) (aka x-ray repair cross complementing 4)
B: xrcc9 (homo sapiens) (aka fa complementation group g)
C: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
D: dna ligase 4 (homo sapiens) (aka dna ligase 4)
E: dna ligase 4-like (xenopus laevis) (aka dna ligase 4-like)
F: xrcc7 (homo sapiens) (aka protein kinase, dna-activated, catalytic subunit)
G: dna ligase iv (arabidopsis thaliana) (aka dna ligase iv)
H: xrcc3 (homo sapiens) (aka x-ray repair cross complementing 3)
I: xrcc4.l (xenopus laevis) (aka x-ray repair complementing defective repair in chinese hamster cells 4 l homeolog)
J: lig4 (saccharomyces cerevisiae s288c) (aka dna ligase (atp) dnl4)
K: None of the above. | [D; A] |
<Instruct>: Given the context 'We found that non-histone chromosomal high mobility group (HMG) proteins 1 and 2 enhanced the ligation of linearized pUC119 DNA with DNA ligase IV from rat liver nuclear extract.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna ligase iv]
<Options>: A: dna ligase 4 (homo sapiens) (aka dna ligase 4)
B: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
C: dna ligase iv (arabidopsis thaliana) (aka dna ligase iv)
D: ligase iv, dna, atp-dependent (mus musculus) (aka ligase iv, dna, atp-dependent)
E: ligase iv, dna, atp-dependent (danio rerio) (aka ligase iv, dna, atp-dependent)
F: None of the above. | [A] |
<Instruct>: Given the context 'Recombinant HMG2-domain A, B, and (A + B) polypeptides were similarly, but non-identically, effective for the stimulation of DSB ligation reaction.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [hmg2]
<Options>: A: hmgn2p (homo sapiens) (aka high mobility group nucleosomal binding domain 2 pseudogene 1)
B: hmgb2 (homo sapiens) (aka high mobility group box 2)
C: hmgn2 (homo sapiens) (aka high mobility group nucleosomal binding domain 2)
D: hmg2l1 (homo sapiens) (aka hmg-box containing 4)
E: hmga2 (homo sapiens) (aka high mobility group at-hook 2)
F: None of the above. | [B] |
<Instruct>: Given the context 'The DNA end-binding Ku protein singly or in combination with the catalytic component of DNA-dependent protein kinase (DNA-PK) as the DNA-PK holoenzyme was ineffective for the ligation of linearized pUC119 DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna-dependent protein kinase; dna-pk]
<Options>: A: protein kinase, dna activated, catalytic polypeptide (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
B: dna-pkcs (xenopus tropicalis) (aka protein kinase, dna-activated, catalytic subunit)
C: dna-pkcs (xenopus laevis) (aka protein kinase, dna-activated, catalytic subunit l homeolog)
D: chaperone protein dnak (escherichia coli str. k-12 substr. mg1655) (aka chaperone protein dnak)
E: dna-pkcs (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
F: protein kinase, dna-activated, catalytic subunit (homo sapiens) (aka protein kinase, dna-activated, catalytic subunit)
G: protein kinase, dna-activated, catalytic subunit (danio rerio) (aka protein kinase, dna-activated, catalytic subunit)
H: None of the above. | [F; F] |
<Instruct>: Given the context 'The DNA end-binding Ku protein singly or in combination with the catalytic component of DNA-dependent protein kinase (DNA-PK) as the DNA-PK holoenzyme was ineffective for the ligation of linearized pUC119 DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna-dependent protein kinase; dna-pk]
<Options>: A: protein kinase, dna activated, catalytic polypeptide (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
B: dna-pkcs (xenopus tropicalis) (aka protein kinase, dna-activated, catalytic subunit)
C: chaperone protein dnak (escherichia coli str. k-12 substr. mg1655) (aka chaperone protein dnak)
D: protein kinase, dna-activated, catalytic subunit (danio rerio) (aka protein kinase, dna-activated, catalytic subunit)
E: dna-pkcs (xenopus laevis) (aka protein kinase, dna-activated, catalytic subunit l homeolog)
F: dna-pkcs (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
G: None of the above. | [G; G] |
<Instruct>: Given the context 'The DNA end-binding Ku protein singly or in combination with the catalytic component of DNA-dependent protein kinase (DNA-PK) as the DNA-PK holoenzyme was ineffective for the ligation of linearized pUC119 DNA.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna-dependent protein kinase; dna-pk]
<Options>: A: protein kinase, dna-activated, catalytic subunit (rattus norvegicus) (aka protein kinase, dna-activated, catalytic subunit)
B: dna-pkcs (homo sapiens) (aka protein kinase, dna-activated, catalytic subunit)
C: protein kinase, dna-activated, catalytic subunit (danio rerio) (aka protein kinase, dna-activated, catalytic subunit)
D: dna-pkcs (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
E: chaperone protein dnak (escherichia coli str. k-12 substr. mg1655) (aka chaperone protein dnak)
F: dna-pkcs (xenopus laevis) (aka protein kinase, dna-activated, catalytic subunit l homeolog)
G: protein kinase, dna activated, catalytic polypeptide (mus musculus) (aka protein kinase, dna activated, catalytic polypeptide)
H: dna-pkcs (xenopus tropicalis) (aka protein kinase, dna-activated, catalytic subunit)
I: None of the above. | [B; B] |
<Instruct>: Given the context 'Although the stimulatory effect of HMG1 and 2 on ligation of DSB in vitro was not specific to DNA ligase IV, these results suggest that HMG1 and 2 are involved in the final ligation step in DNA end-joining processes of DSB repair and V(D)J recombination.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [dna ligase iv]
<Options>: A: ligase iv (drosophila melanogaster) (aka dna ligase 4)
B: lig4 (saccharomyces cerevisiae s288c) (aka dna ligase (atp) dnl4)
C: dna ligase 4 (homo sapiens) (aka dna ligase 4)
D: dna ligase 4 (oryctolagus cuniculus) (aka dna ligase 4)
E: dna ligase iv (caenorhabditis elegans) (aka dna ligase iv)
F: None of the above. | [C] |
<Instruct>: Given the context 'A search of the yeast data base for a protein homologous to Escherichia coli UDP-N-acetylglucosamine pyrophosphorylase yielded UAP1 (UDP-N-acetylglucosamine pyrophosphorylase), the Saccharomyces cerevisiae gene for UDP-N-acetylglucosamine pyrophosphorylase.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1]
<Options>: A: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
C: upp1 (homo sapiens) (aka uridine phosphorylase 1)
D: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
E: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; agx1]
<Options>: A: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
B: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
C: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
D: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
E: agx1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
F: agx1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog)
G: agmx1 (homo sapiens) (aka bruton tyrosine kinase)
H: upp1 (homo sapiens) (aka uridine phosphorylase 1)
I: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
J: None of the above. | [D; D] |
<Instruct>: Given the context 'Sequence analysis revealed that the human UAP1 cDNA was identical to previously reported AGX1.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; agx1]
<Options>: A: agx1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog)
B: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
C: ag1 (xenopus laevis) (anterior gradient 1 l homeolog (xenopus laevis)) (aka anterior gradient 1 l homeolog)
D: agx1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog)
E: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
F: uap (homo sapiens) (aka ubiquitin associated protein 1)
G: upp1 (homo sapiens) (aka uridine phosphorylase 1)
H: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
I: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
J: None of the above. | [H; H] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: cluap1 (sus scrofa) (aka clusterin associated protein 1)
B: cluap1 (xenopus laevis) (aka clusterin associated protein 1 l homeolog)
C: upp1 (homo sapiens) (aka uridine phosphorylase 1)
D: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
E: uca1 (homo sapiens) (aka urothelial cancer associated 1)
F: urp1 (homo sapiens) (aka ferm domain containing kindlin 1)
G: ura1 (homo sapiens) (aka dihydroorotate dehydrogenase (quinone))
H: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
I: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
J: uap (homo sapiens) (aka ubiquitin associated protein 1)
K: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
L: upla1 (homo sapiens) (aka gjd3 antisense rna 1)
M: uba5p1 (homo sapiens) (aka uba5 pseudogene 1)
N: None of the above. | [K; K; D] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: azu1p1 (homo sapiens) (aka azurocidin 1 pseudogene 1)
C: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
D: urp1 (homo sapiens) (aka ferm domain containing kindlin 1)
E: uap1l1 (xenopus laevis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1 l homeolog)
F: uba5p1 (homo sapiens) (aka uba5 pseudogene 1)
G: clusterin associated protein 1 (sus scrofa) (aka clusterin associated protein 1)
H: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
I: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
J: upp1 (homo sapiens) (aka uridine phosphorylase 1)
K: uca1 (homo sapiens) (aka urothelial cancer associated 1)
L: cluap1 (homo sapiens) (aka clusterin associated protein 1)
M: uap (homo sapiens) (aka ubiquitin associated protein 1)
N: cluap1 (xenopus laevis) (aka clusterin associated protein 1 l homeolog)
O: None of the above. | [C; C; A] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1; scuap1; hsuap1]
<Options>: A: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
B: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
C: up1a (xenopus laevis) (uroplakin 1a s homeolog (xenopus laevis)) (aka uroplakin 1a s homeolog)
D: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
E: upp1 (homo sapiens) (aka uridine phosphorylase 1)
F: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
G: cluap1 (homo sapiens) (aka clusterin associated protein 1)
H: uca1 (homo sapiens) (aka urothelial cancer associated 1)
I: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
J: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
K: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
L: cluap1 (xenopus tropicalis) (aka clusterin associated protein 1)
M: uba5p1 (homo sapiens) (aka uba5 pseudogene 1)
N: None of the above. | [F; F; D] |
<Instruct>: Given the context 'A null mutation of the S. cerevisiae UAP1 (ScUAP1) gene was lethal, and when expressed under the control of ScUAP1 promoter, both C. albicans and Homo sapiens UAP1 (CaUAP1 and HsUAP1) rescued the ScUAP1-deficient S. cerevisiae cells.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scuap1]
<Options>: A: uca1 (homo sapiens) (aka urothelial cancer associated 1)
B: cluap1 (xenopus tropicalis) (aka clusterin associated protein 1)
C: up1a (xenopus laevis) (uroplakin 1a s homeolog (xenopus laevis)) (aka uroplakin 1a s homeolog)
D: cluap1 (xenopus laevis) (aka clusterin associated protein 1 l homeolog)
E: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
F: None of the above. | [F] |
<Instruct>: Given the context 'All the recombinant ScUap1p, CaUap1p, and HsUap1p possessed UDP-N-acetylglucosamine pyrophosphorylase activities in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scuap1p; hsuap1p]
<Options>: A: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
B: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
C: cluap1 (homo sapiens) (aka clusterin associated protein 1)
D: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
E: upp1 (sus scrofa) (aka uridine phosphorylase 1)
F: uba5p1 (homo sapiens) (aka uba5 pseudogene 1)
G: upf3a pseudogene 1 (homo sapiens) (aka upf3a pseudogene 1)
H: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
I: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
J: serum serum amyloid a-1 pseudogene (sus scrofa) (aka serum serum amyloid a-1 pseudogene)
K: None of the above. | [K; B] |
<Instruct>: Given the context 'All the recombinant ScUap1p, CaUap1p, and HsUap1p possessed UDP-N-acetylglucosamine pyrophosphorylase activities in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scuap1p; hsuap1p]
<Options>: A: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
B: upf3a pseudogene 1 (homo sapiens) (aka upf3a pseudogene 1)
C: serum serum amyloid a-1 pseudogene (sus scrofa) (aka serum serum amyloid a-1 pseudogene)
D: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
E: cluap1 (homo sapiens) (aka clusterin associated protein 1)
F: uap1l1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
G: uba5p1 (homo sapiens) (aka uba5 pseudogene 1)
H: upp1 (sus scrofa) (aka uridine phosphorylase 1)
I: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
J: None of the above. | [J; J] |
<Instruct>: Given the context 'All the recombinant ScUap1p, CaUap1p, and HsUap1p possessed UDP-N-acetylglucosamine pyrophosphorylase activities in vitro.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scuap1p; hsuap1p]
<Options>: A: upf3a pseudogene 1 (homo sapiens) (aka upf3a pseudogene 1)
B: cluap1 (homo sapiens) (aka clusterin associated protein 1)
C: cluap1 (sus scrofa) (aka clusterin associated protein 1)
D: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
E: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
F: usp37 pseudogene 1 (homo sapiens) (aka usp37 pseudogene 1)
G: azu1p1 (homo sapiens) (aka azurocidin 1 pseudogene 1)
H: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
I: upp1 (sus scrofa) (aka uridine phosphorylase 1)
J: None of the above. | [J; E] |
<Instruct>: Given the context 'The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1p; agm1p]
<Options>: A: 1-agp (mus musculus) (aka 1-acylglycerol-3-phosphate o-acyltransferase 1)
B: alpha-2-macroglobulin like 1 pseudogene (mus musculus) (aka alpha-2-macroglobulin like 1 pseudogene)
C: uap1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
D: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
E: uap1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog)
F: apm1p (saccharomyces cerevisiae s288c) (aka apm1p)
G: agm1 (saccharomyces cerevisiae s288c) (aka phosphoacetylglucosamine mutase pcm1)
H: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
I: agm1 (homo sapiens) (phosphoglucomutase 3 (homo sapiens)) (aka phosphoglucomutase 3)
J: uap1.s (xenopus laevis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 s homeolog)
K: None of the above. | [D; G] |
<Instruct>: Given the context 'The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1p; agm1p]
<Options>: A: uap1 (saccharomyces cerevisiae s288c) (aka udp-n-acetylglucosamine diphosphorylase)
B: uap1l1 (xenopus laevis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1 l homeolog)
C: uap1 (xenopus laevis) (udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog (xenopus laevis)) (aka udp-n-acetylglucosamine pyrophosphorylase 1 l homeolog)
D: 1-agp (mus musculus) (aka 1-acylglycerol-3-phosphate o-acyltransferase 1)
E: agm1 (mus musculus) (aka phosphoglucomutase 3)
F: uap1l1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
G: agm1 (saccharomyces cerevisiae s288c) (aka phosphoacetylglucosamine mutase pcm1)
H: m1ap (oryctolagus cuniculus) (aka meiosis 1 associated protein)
I: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
J: ap3m1 (oryctolagus cuniculus) (aka adaptor related protein complex 3 subunit mu 1)
K: None of the above. | [A; G] |
<Instruct>: Given the context 'These results demonstrate that the UAP1 genes indeed specify eukaryotic UDP-GlcNAc pyrophosphorylase and that phosphomutase reaction precedes uridyltransfer.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [uap1]
<Options>: A: urp1 (homo sapiens) (aka ferm domain containing kindlin 1)
B: uap (homo sapiens) (aka ubiquitin associated protein 1)
C: uap1 (homo sapiens) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
D: upf1 regulator of nonsense transcripts homolog (xenopus tropicalis) (aka upf1 regulator of nonsense transcripts homolog)
E: uap1l1 (xenopus tropicalis) (aka udp-n-acetylglucosamine pyrophosphorylase 1 like 1)
F: None of the above. | [C] |
<Instruct>: Given the context 'Sequence comparison with other UDP-sugar pyrophosphorylases revealed that amino acid residues, Gly112, Gly114, Thr115, Arg116, Pro122, and Lys123 of ScUap1p are highly conserved in UDP-sugar pyrophosphorylases reported to date.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [scuap1p]
<Options>: A: high affinity copper uptake protein 1 pseudogene (sus scrofa) (aka high affinity copper uptake protein 1 pseudogene)
B: cluap1 (homo sapiens) (aka clusterin associated protein 1)
C: uap1 (sus scrofa) (aka udp-n-acetylglucosamine pyrophosphorylase 1)
D: azu1p1 (homo sapiens) (aka azurocidin 1 pseudogene 1)
E: aup1 (sus scrofa) (aka aup1 lipid droplet regulating vldl assembly factor)
F: None of the above. | [F] |
<Instruct>: Given the context 'Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1; myc]
<Options>: A: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
B: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
C: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
D: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
E: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
F: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
G: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
H: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
I: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
J: c-myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
K: None of the above. | [D; J] |
<Instruct>: Given the context 'Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1; myc]
<Options>: A: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
D: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
E: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
F: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
G: mycl (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
H: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
I: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
J: None of the above. | [F; J] |
<Instruct>: Given the context 'Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1; myc]
<Options>: A: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
B: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
C: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
D: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
E: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
F: myc-like oncogene, s-myc protein (mus musculus) (aka myc-like oncogene, s-myc protein)
G: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
H: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
I: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
J: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
K: None of the above. | [I; H] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc; max]
<Options>: A: max (homo sapiens) (aka myc associated factor x)
B: basic helix-loop-helix (bhlh) dna-binding protein (glycine max) (aka basic helix-loop-helix (bhlh) dna-binding protein)
C: homeodomain/homeobox transcription factor (glycine max) (aka homeodomain/homeobox transcription factor)
D: basic helix-loop-helix transcription factor (glycine max) (aka basic helix-loop-helix transcription factor)
E: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
F: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (mus musculus) (aka v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)
G: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
H: max homolog 1 (xenopus laevis) (aka max homolog 1)
I: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
J: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
K: None of the above. | [I; A] |
<Instruct>: Given the context 'This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [myc; max]
<Options>: A: c-myc-binding protein homolog (glycine max) (aka c-myc-binding protein homolog)
B: max (homo sapiens) (aka myc associated factor x)
C: protein max-like (homo sapiens) (aka protein max-like)
D: v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus) (aka v-myc avian myelocytomatosis viral oncogene homolog)
E: max homolog 1 (xenopus laevis) (aka max homolog 1)
F: homeodomain/homeobox transcription factor (glycine max) (aka homeodomain/homeobox transcription factor)
G: basic helix-loop-helix (bhlh) dna-binding protein (glycine max) (aka basic helix-loop-helix (bhlh) dna-binding protein)
H: myc (homo sapiens) (aka myc proto-oncogene, bhlh transcription factor)
I: myc (mus musculus) (myelocytomatosis oncogene (mus musculus)) (aka myelocytomatosis oncogene)
J: mycl proto-oncogene, bhlh transcription factor (homo sapiens) (aka mycl proto-oncogene, bhlh transcription factor)
K: None of the above. | [H; B] |
<Instruct>: Given the context 'Mad(Mxi1) proteins have been suggested to be essential in cellular growth control and/or in the induction and maintenance of the differentiated state.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
D: mx-1 (mus musculus) (aka mx dynamin-like gtpase 1)
E: mxi (homo sapiens) (aka max interactor 1, dimerization protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'Consistent with these roles, mxi1 may be the tumour-suppressor gene that resides at region 24-26 of the long arm of chromosome 10.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: mx-1 (mus musculus) (aka mx dynamin-like gtpase 1)
B: mxi1-rs1 (mus musculus) (aka max interacting protein 1, related sequence 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein l homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein l homeolog)
D: mxi1 (mus musculus) (aka max interactor 1, dimerization protein)
E: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
F: None of the above. | [E] |
<Instruct>: Given the context 'Here we show that mice lacking Mxi1 exhibit progressive, multisystem abnormalities.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [mxi1]
<Options>: A: mxi1 (homo sapiens) (aka max interactor 1, dimerization protein)
B: mx-1 (mus musculus) (aka mx dynamin-like gtpase 1)
C: mxi (xenopus laevis) (max interactor 1, dimerization protein s homeolog (xenopus laevis)) (aka max interactor 1, dimerization protein s homeolog)
D: max interactor 1, dimerization protein (mus musculus) (aka max interactor 1, dimerization protein)
E: mx1 (homo sapiens) (aka mx dynamin like gtpase 1)
F: None of the above. | [D] |
<Instruct>: Given the context 'These mice also show increased susceptibility to tumorigenesis either following carcinogen treatment or when also deficient in Ink4a.', select the correct biomedical concept for each mention using the provided options. Answer by listing the selected options, one for each mention, separated by semicolon. | <Mentions>: [ink4a]
<Options>: A: ink4b (homo sapiens) (aka cyclin dependent kinase inhibitor 2b)
B: p16ink4 (homo sapiens) (aka cyclin dependent kinase inhibitor 2a)
C: ink4d (homo sapiens) (aka cyclin dependent kinase inhibitor 2d)
D: ink4c (homo sapiens) (aka cyclin dependent kinase inhibitor 2c)
E: cdkn4 (homo sapiens) (aka cyclin dependent kinase inhibitor 1b)
F: None of the above. | [F] |
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