Subset (2)

scifact_data · 1.11k rows

Split (2)

train · 809 rows

question_id stringlengths 1 4	question stringlengths 26 249	pos_item_ids listlengths 1 5	pos_item_contents listlengths 1 5
1324	Treatment with a protein named FN restores regenerative abilities of aged muscles.	[ "19912367" ]	[ "Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle contains substantially reduce...
1325	Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility.	[ "40476126" ]	[ "Functional role of high-affinity anandamide transport, as revealed by selective inhibition.. Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport in...
1327	Tuberculosis incidence occurs at higher rates in more sparsely populated areas in the UK.	[ "24241932", "22194407" ]	[ "Ecological analysis of ethnic differences in relation between tuberculosis and poverty.. OBJECTIVE To examine the effect of ethnicity on the relation between tuberculosis and deprivation. DESIGN Retrospective ecological study comparing incidence of tuberculosis in white and south Asian residents of the 39 electora...
1328	Tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue.	[ "3475317" ]	[ "Inflammatory signaling in human Tuberculosis granulomas is spatially organized. Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subje...
1330	Tumor development occurs in conjunction with suppression of pro-inflammatory cytokines.	[ "14075252" ]	[ "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interaction...
1331	Tumor development occurs in conjunction with upregulation of pro-inflammatory cytokines.	[ "14075252" ]	[ "Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interaction...
1333	Two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients.	[ "1649738" ]	[ "Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Survivors of pediatric Hodgkin's lymphoma are at risk for radiation therapy–induced second malignant neoplasms (SMNs). We identified two variants at chromosome 6q21 associated with SMNs in survivors of...
1334	Type 1 Diabetes is associated with subtle perturbations in T reg development.	[ "13923140", "13940200", "11899391" ]	[ "Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with diff...
134	Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes.	[ "4695046" ]	[ "Anxiety. OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controlled Trials Register, and hand searches of key journals. MET...
1340	Ultrasound guidance significantly reduces the number of needle insertion attempts necessary for a given procedure.	[ "15482274" ]	[ "Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.. OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging c...
1341	Ultrasound guidance significantly reduces the number of traumatic procedures when attempting needle insertion.	[ "15482274" ]	[ "Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis.. OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging c...
1342	Understanding epigenetic regulation of replication is essential for the reational design of episomally replicating vectors.	[ "8148122" ]	[ "Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation. DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these \"replicon clus...
1345	Up-regulation of the p53 pathway and related molecular events speeds cancer progression.	[ "9559146" ]	[ "Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors. Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This resp...
1346	Upon developing tyrosine-kinase inhibitor resistance, new mutations in epidermal growth factor receptors emerge and cause treatment failure.	[ "9505402" ]	[ "Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M. Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibit...
1347	Upon viral challenge, influenza-specific memory CD4+ T cells greatly diminish the early production of inflammatory chemokines in the lung.	[ "19005293" ]	[ "Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory respons...
1348	Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung.	[ "19005293" ]	[ "Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory respons...
1349	Upregulation of PD1 causes the downmodulation of Satb1.	[ "5377642" ]	[ "SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells. &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐bind...
1350	Upregulation of PD1 causes the upregulation of Satb1.	[ "5377642" ]	[ "SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells. &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐bind...
1351	Upregulation of dynein in Drosophila neurons increases the number of microtubule plus-ends growing toward the cell body of each neuron.	[ "28369117" ]	[ "Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling...
1353	Urbanization is an important risk factor related to the transmission of dengue fever.	[ "18816720" ]	[ "Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages. BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and...
1355	V-9302 inhibits antitumor responses by decreasing cell death and oxidative stress.	[ "5256564" ]	[ "Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models. The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has...
1356	Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa.	[ "13764090" ]	[ "Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection. Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in ani...
1360	Varenicline monotherapy is more effective after 26 weeks of treatment compared to combination nicotine replacement therapies with varenicline or bupropion.	[ "11614737" ]	[ "Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.. IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR...
1361	Varying expression levels of EBI2 affect the positioning and migration of B cells.	[ "15488881", "15058155" ]	[ "Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.. Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal cente...
1364	Venules have less significant tunica adventitia than arterioles.	[ "8290953" ]	[ "Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.. BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the dama...
1366	VgrG (Tssl) protein punctures membranes by forming a spike at the tip of the tube apparatus.	[ "4406819" ]	[ "PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike. The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of t...
1367	Vitamin D deficiency effects birth weight.	[ "2425364" ]	[ "Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies.. OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. DESIGN Systematic review and meta-analysi...
1371	Vitamin D is an important factor in the relationship between calcium and parathyroid hormone.	[ "16256507" ]	[ "Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.. CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of v...
1372	Walking in traffic areas in London did not improve lung function in elderly adults.	[ "21003930" ]	[ "Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. BACKGROUND Long-term exposure to pollution can le...
1373	Walking in traffic areas in London improves lung function in elderly adults.	[ "21003930" ]	[ "Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. BACKGROUND Long-term exposure to pollution can le...
1374	Weighed food records (WFR) result in high completion since they're cheap to run and impose low participant burden.	[ "21993510" ]	[ "Accuracy of weighed dietary records in studies of diet and health.. OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. DESI...
1375	Weighed food records (WFR) result in poor completion since they're costly to run and impose high participant burden.	[ "21993510" ]	[ "Accuracy of weighed dietary records in studies of diet and health.. OBJECTIVE To provide an independent evaluation of seven day weighed dietary records, which are currently accepted as the most accurate technique for assessing habitual dietary intake in studies investigating the links between diet and health. DESI...
1376	Whole brain radiotherapy increases the occurrence of new brain metastases.	[ "3944632" ]	[ "Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.. CONTEXT In patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS)...
1378	Women are more susceptible to death due to pneumonia when compared to men.	[ "2488880" ]	[ "Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.. CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. OBJECTIVE To investigate the role of gender among ...
138	Asymptomatic visual impairment screening in elderly populations leads to improved vision.	[ "26016929" ]	[ "Effectiveness of screening older people for impaired vision in community setting: systematic review of evidence from randomised controlled trials.. OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of r...
1380	Women with a lower birth weight are more likely to develop breast cancer later in life.	[ "16322674", "23557241", "17450673" ]	[ "Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies. BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual particip...
1381	YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis.	[ "13481880" ]	[ "YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage. Here we...
1383	aPKCz causes tumour suppression by affecting glutamine metabolism.	[ "17755060" ]	[ "Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis. Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity nece...
1386	cSMAC formation represses weak ligand signalling.	[ "306006" ]	[ "The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.. T cell activation is predicated on the interaction between the T cell receptor and peptide-major histocompatibility (pMHC) ligands. The factors that determine the stimulatory potency of a pMHC molecule remain u...
1387	eRNAs influence is linked to senescence, aging, and carcinogenesis.	[ "9669099" ]	[ "eRNAs are required for p53-dependent enhancer activity and gene transcription.. Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we descri...
139	At least 85% of patients exposed to radiation have activated markers of myofibroblasts.	[ "22080671" ]	[ "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods ...
1390	mcm 5 s 2 U is required for proper decoding of NNR codons in eukaryotes.	[ "2890952" ]	[ "Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. The wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group confers conformational r...
1391	miR-142-5P is a known regulator of raised body temperature.	[ "6766459" ]	[ "RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever. Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poor...
1392	miR-142-5P is a temperature-sensitive microRNA (miRNA).	[ "6766459" ]	[ "RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever. Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poor...
1393	miRNAs enforce homeostasis by suppressing low-level ''leaky'' transcription.	[ "2000038", "12440953" ]	[ "MicroRNAs can generate thresholds in target gene expression. MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target ge...
1394	miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells.	[ "2251426" ]	[ "microRNAs: A Safeguard against Turmoil?. Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression duri...
1397	p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs).	[ "17717391" ]	[ "Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model. Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a), a tumor suppressor and aging biomarker. Lifelong asse...
1398	p16INK4A degradation is encoded by CDKN2A.	[ "17717391" ]	[ "Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model. Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a), a tumor suppressor and aging biomarker. Lifelong asse...
14	5'-nucleotidase metabolizes 6MP.	[ "641786" ]	[ "Relapse specific mutations in NT5C2 in childhood acute lymphoblastic leukemia. Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report the transcri...
1400	p75 NTR - associated cell death executor (NADE) interacts with the p75 NTR death domain	[ "14706752" ]	[ "Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor. The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show t...
1401	qSOFA scores are associated with length of stay in emergency department patients.	[ "5185871" ]	[ "Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. Importance The Sepsis-3 Criteria emphasized the value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessmen...
1402	r-protein chaperones are found in complexes with their r-protein binding partners.	[ "8126244" ]	[ "Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics. Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartme...
1403	siRNA knockdown of A20 accelerates tumor progression in an in vivo murine xenograft model.	[ "33370", "38355793" ]	[ "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets....
1404	siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model.	[ "33370", "38355793" ]	[ "Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets....
1405	taa1 tar1 tar2 triple mutants in Arabidopsis do not make root meristem during embryogenesis.	[ "10504681" ]	[ "TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development. Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental signals is a critical mechanism in the generation of t...
1406	β-sheet opening occurs during pleurotolysin pore formation.	[ "2617858" ]	[ "Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores ...
1407	β1/Ketel is able to bind microtubules.	[ "8087082", "29863668" ]	[ "A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-asso...
144	Autologous transplantation of mesenchymal stem cells has better graft function than induction therapy with anti-interleukin-2 receptor antibodies.	[ "10582939" ]	[ "Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial.. CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remai...
149	Autophagy deficiency in the liver increases vulnerability to insulin resistance.	[ "6227220" ]	[ "Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-...
15	50% of patients exposed to radiation have activated markers of mesenchymal stem cells.	[ "22080671" ]	[ "KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods ...
152	B cells go though plasmablast differentiation and antibody production by continuous expression of EBI2.	[ "15488881" ]	[ "Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.. Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal cente...
153	B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.	[ "4702639" ]	[ "An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition. Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that ar...
154	B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR.	[ "4702639" ]	[ "An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition. Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that ar...
155	BCL-2 activation antagonizes the apoptotic effects of c-Myc.	[ "37549932" ]	[ "Antiapoptotic BCL-2 is required for maintenance of a model leukemia.. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To tes...
156	BCL-2 promotes the apoptotic effects of c-Myc.	[ "37549932" ]	[ "Antiapoptotic BCL-2 is required for maintenance of a model leukemia.. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it remains uncertain whether apoptotic defects are essential for tumor maintenance. To tes...
157	BLM gene encodes RecQ-class DNA helicase.	[ "13439128" ]	[ "The Bloom's syndrome gene product is homologous to RecQ helicases. The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had bee...
159	BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located.	[ "9394119" ]	[ "Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.. IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE To identify mutation-specific cancer risks for carriers of BRCA1/2. D...
160	Bacterial meningitis can be diagnosed on the basis of positive cerebrospinal fluid (CSF) cultures.	[ "52874170" ]	[ "How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?. CONTEXT Diagnostic lumbar punctures (LPs), commonly used to rule out meningitis, are associated with adverse events. OBJECTIVE To systematically review the evidence about diagnostic LP techniques that may decrease the ris...
161	Bacteriophagaes MS2 and Qβ are members of the Leviviridae.	[ "6903077" ]	[ "Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ. In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determined the asymmetric virion structure of bact...
164	Bariatric surgery increases rates of colorectal cancer.	[ "5824985" ]	[ "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ...
165	Bariatric surgery increases rates of postmenopausal breast cancer.	[ "5824985" ]	[ "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ...
166	Bariatric surgery leads to negative outcomes in mental health.	[ "18872233" ]	[ "Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surge...
167	Bariatric surgery leads to positive outcomes in mental health.	[ "18872233" ]	[ "Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surge...
168	Bariatric surgery reduces colorectal cancer.	[ "5824985" ]	[ "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ...
169	Bariatric surgery reduces postmenopausal breast cancer.	[ "5824985" ]	[ "Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ...
17	53% of perinatal mortality is due to low birth weight.	[ "1606628" ]	[ "Estimates of global prevalence of childhood underweight in 1990 and 2015.. CONTEXT One key target of the United Nations Millennium Development goals is to reduce the prevalence of underweight among children younger than 5 years by half between 1990 and 2015. OBJECTIVE To estimate trends in childhood underweight by...
172	Basophils promote disease development in patients with systemic lupus erythematosus (SLE).	[ "12670680" ]	[ "BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS. In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes t...
173	Bcp1 is a chaperone for Rpl23.	[ "8126244" ]	[ "Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics. Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartme...
174	Beta-band coherence is diminished for visible stimuli over invisible stimuli.	[ "1710116" ]	[ "Converging Intracranial Markers of Conscious Access. We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas,...
175	Beta-band coherence is enhanced for visible stimuli over invisible stimuli.	[ "1710116" ]	[ "Converging Intracranial Markers of Conscious Access. We compared conscious and nonconscious processing of briefly flashed words using a visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten patients. Nonconscious processing of masked words was observed in multiple cortical areas,...
176	BiP is a general endoplasmic reticulum stress marker.	[ "32587939" ]	[ "Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an imp...
177	Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs.	[ "9669099" ]	[ "eRNAs are required for p53-dependent enhancer activity and gene transcription.. Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we descri...
178	Birth-weight is negatively associated with breast cancer.	[ "16322674", "27123743", "23557241", "17450673" ]	[ "Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies. BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual particip...
18	61% of colorectal cancer patients are diagnosed with regional or distant metastases.	[ "22942787" ]	[ "Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer.. CONTEXT Medicare's reimbursement policy was changed in 1998 to provide coverage for screening colonoscopies for patients with increased colon cancer risk, and expanded further in 2001 to cover screening ...
181	Blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevents TDP-43-induced neuronal loss.	[ "16966326" ]	[ "The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity. Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological...
182	Bone Marrow (BM) transplantation is used to treat acute myeloid leukemia (AML)	[ "11369420" ]	[ "Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.. Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward develop...
184	Bone marrow cells don't contribute to adult macrophage compartments.	[ "12827098" ]	[ "Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.. Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis...
186	British female students are bullied more than British male students.	[ "16855829" ]	[ "Bullying in school: are short pupils at risk? Questionnaire study in a cohort.. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker th...
187	British male students are bullied more than British female students.	[ "16855829" ]	[ "Bullying in school: are short pupils at risk? Questionnaire study in a cohort.. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker th...
189	Broadly HIV-1 Neutralizing Antibodies (bnAb) 10EB have no affinity for phospholipids.	[ "4421578" ]	[ "Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neu...
19	7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults.	[ "3202143" ]	[ "Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age. Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning an...
196	C2 works synergistically with A-769662 to activate dephosphorylated AMPK.	[ "19313533" ]	[ "Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.. The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the tre...
197	CCL19 is a ligand for CCR7.	[ "2177022" ]	[ "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.. Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migrat...
199	CCL19 is predominantly present within dLNs.	[ "2177022" ]	[ "Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells.. Chemokines orchestrate immune cell trafficking by eliciting either directed or random migration and by activating integrins in order to induce cell adhesion. Analyzing dendritic cell (DC) migrat...
2	1 in 5 million in UK have abnormal PrP positivity.	[ "13734012" ]	[ "Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions aft...
20	7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults.	[ "3202143" ]	[ "Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age. Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning an...
200	CD28 initiates tonic signaling in conventional T cells, which causes an exhaustion phenotype and limited efficiency.	[ "18231807" ]	[ "4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors. Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remai...
201	CD28 signals regulate trafficking of murine auto-reactive T cells into target tissues.	[ "2462673" ]	[ "CD28 and ITK signals regulate autoreactive T cell trafficking. Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic...
203	CD44v6 is not associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis.	[ "9558539" ]	[ "CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.. Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is requi...
204	CDK6 shows impaired binding to loss-of-function variants of p18 INK4C.	[ "7898952" ]	[ "Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development. We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional rec...

Subsets and Splits

No community queries yet

The top public SQL queries from the community will appear here once available.