question_id stringlengths 1 4 | question stringlengths 26 249 | pos_item_ids listlengths 1 5 | pos_item_contents listlengths 1 5 |
|---|---|---|---|
205 | CDK6 shows improved binding to loss-of-function variants of p18 INK4C. | [
"7898952",
"470625"
] | [
"Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development. We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional rec... |
209 | CHOP is a general endoplasmic reticulum stress marker. | [
"32587939"
] | [
"Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an imp... |
21 | 70% of burn patients are admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics. | [
"41493639"
] | [
"ABC of burns. Introduction.. Burns are one of the most devastating conditions encountered in medicine. The injury represents an assault on all aspects of the patient, from the physical to the psychological. It affects all ages, from babies to elderly people, and is a problem in both the developed and developing wo... |
210 | COPI coatmer is involved in lipid homeostasis. | [
"13794374"
] | [
"COPI Complex Is a Regulator of Lipid Homeostasis. Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte... |
211 | COPI coatmer is involved in viral replication. | [
"13794374"
] | [
"COPI Complex Is a Regulator of Lipid Homeostasis. Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte... |
214 | CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. | [
"13625993"
] | [
"Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery. OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of pat... |
22 | 76-85% of people with severe mental disorder receive no treatment in low and middle income countries. | [
"6490571"
] | [
"Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys.. CONTEXT Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries. OBJECTIVE To estimate prevalence, severity, and treatment... |
220 | Ca2+ cycling controls whole-body energy homeostasis in beige fat. | [
"19205437"
] | [
"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-indepen... |
221 | Ca2+ cycling is a UCP1-dependent thermogenic mechanism. | [
"19205437"
] | [
"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-indepen... |
222 | Ca2+ cycling is a UCP1-independent thermogenic mechanism. | [
"19205437"
] | [
"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-indepen... |
223 | Cancer cells can stimulate the accumulation of intra-tumoural myeloid-derived suppressor cells by promoting granulocyte colony stimulating factor production. | [
"2014909"
] | [
"Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanism... |
224 | Cancer-associated fibroblasts (CAFs) are constituents of tumor microenvironments | [
"6944800"
] | [
"Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attracti... |
225 | Cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs. | [
"6944800"
] | [
"Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attracti... |
226 | Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs. | [
"6944800"
] | [
"Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attracti... |
227 | Cancers that initially benefit from epidermal growth factor receptor targeted therapies later become refractory through several mechanisms. | [
"26973393"
] | [
"The quest to overcome resistance to EGFR-targeted therapies in cancer. All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually develop resistance. An increasing understanding of the number an... |
228 | Cardiac tissue-resident macrophages directly contribute to electrical activity. | [
"4928057"
] | [
"Macrophages Facilitate Electrical Conduction in the Heart. Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with... |
229 | Carriers of HNF4A mutations are at reduced risk for diabetes. | [
"56893404"
] | [
"Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant wome... |
235 | Cell autonomous sex determination in somatic cells occurs in Galliformes. | [
"4388470"
] | [
"Somatic sex identity is cell-autonomous in the chicken. In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to ... |
24 | 90% of patients with melanoma and an objective response to PD-1 blockade will experience a progression in their melanoma. | [
"3471191"
] | [
"Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma.. IMPORTANCE The programmed death 1 (PD-1) pathway limits immune responses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab. OBJECTIVE To characterize the association of ... |
241 | Cellular clocks are associated with mitosis timing in NIH 3T3 cells. | [
"2212067",
"10608822"
] | [
"Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells. Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual intera... |
242 | Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells. | [
"2212067",
"10608822"
] | [
"Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells. Circadian cycles and cell cycles are two fundamental periodic processes with a period in the range of 1 day. Consequently, coupling between such cycles can lead to synchronization. Here, we estimated the mutual intera... |
243 | Cellular differentiation of embryonic stem cells is accompanied by changes in replication timing, transcription and nuclear localization. | [
"8148122"
] | [
"Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation. DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these \"replicon clus... |
244 | Certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides are recognized by toll-like receptors (TLRs) on macrophages and dendritic cells. | [
"21498497"
] | [
"TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited. ... |
245 | Charcoal is an effective treatment for acute paraquat poisoning. | [
"8447873",
"3430789"
] | [
"Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.. BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best th... |
246 | Charcoal shows no benefit for acute paraquat poisoning. | [
"8447873",
"3430789"
] | [
"Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.. BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best th... |
247 | Chemical injury represses transglutaminase 2 activity. | [
"13578199"
] | [
"Transglutaminase 2 Undergoes a Large Conformational Change upon Activation . Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of ... |
25 | 90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months. | [
"2613775"
] | [
"Sudden infant death syndrome.. Despite declines in prevalence during the past two decades, sudden infant death syndrome (SIDS) continues to be the leading cause of death for infants aged between 1 month and 1 year in developed countries. Behavioural risk factors identified in epidemiological studies include prone ... |
250 | Chenodeoxycholic acid treatment decreases brown adipose tissue activity. | [
"1568684"
] | [
"The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.. The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodo... |
251 | Chenodeoxycholic acid treatment increases brown adipose tissue activity. | [
"1568684"
] | [
"The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.. The interest in brown adipose tissue (BAT) as a target to combat metabolic disease has recently been renewed with the discovery of functional BAT in humans. In rodents, BAT can be activated by bile acids, which activate type 2 iodo... |
253 | Chinese individuals with TT homozygosity in the MTHFR gene are less vulnerable to strokes caused by low levels of folate intake. | [
"37424881"
] | [
"The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.. OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate ... |
254 | Chinese individuals with TT homozygosity in the MTHFR gene are more vulnerable to strokes caused by low levels of folate intake. | [
"37424881"
] | [
"The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis.. OBJECTIVE Folate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate ... |
255 | Chlamydia trachomatis is most prevalent in the UK among individuals in their 50s and 60s. | [
"5850219"
] | [
"Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). BACKGROUND Population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes... |
256 | Chlamydia trachomatis is most prevalent in the UK among sexually-experienced individuals aged 16 to 24. | [
"5850219"
] | [
"Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal). BACKGROUND Population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes... |
258 | Cholesterol loading induces KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines. | [
"22080671"
] | [
"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atherosclerosis have provided controversial results owing to the use of unreliable methods ... |
259 | Chronic HIV stimulation of B cells leads to the premature exhaustion of B cells. | [
"8883846"
] | [
"Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions. The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses. The... |
26 | A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 1 year of weekly intake. | [
"32390525"
] | [
"Prevention of malaria in long-term travelers.. CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria prevention primarily address prevention of Plasmodium falciparum infections in short... |
262 | Cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites. | [
"14610165"
] | [
"Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription. Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding antisense transcripts, collectively called COOLAIR, pr... |
263 | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle. | [
"11328820",
"30041340",
"14853989"
] | [
"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neu... |
264 | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to perpetuate the inflammatory cycle via induction of autoantibodies. | [
"11328820"
] | [
"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neu... |
265 | Clathrin stabilizes the spindle fiber apparatus during mitosis. | [
"2033917"
] | [
"Clathrin is required for the function of the mitotic spindle. Clathrin has an established function in the generation of vesicles that transfer membrane and proteins around the cell. The formation of clathrin-coated vesicles occurs continuously in non-dividing cells, but is shut down during mitosis, when clathrin c... |
266 | Cnn1 recruitment varies with cell cycle timing. | [
"22405338"
] | [
"Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segregation are mediated by the multi-copy KNL1Spc105, MIS12M... |
267 | Cognitive behavioral therapy is an ineffective treatment for insomnia | [
"5912283",
"31554917"
] | [
"Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.. CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested ben... |
27 | A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake. | [
"32390525"
] | [
"Prevention of malaria in long-term travelers.. CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria prevention primarily address prevention of Plasmodium falciparum infections in short... |
272 | Combination nicotine replacement therapies with varenicline or bupropion are more effective after 12 weeks of reatment compared to varenicline monotherapy. | [
"11614737"
] | [
"Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.. IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR... |
277 | Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD. | [
"14376683"
] | [
"Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.. The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized t... |
278 | Commelina yellow mottle virus' (ComYMV) genome consists of 2140 baise pairs. | [
"14376683"
] | [
"Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.. The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized t... |
28 | A T helper 2 cell (Th2) environment impedes disease development in patients with systemic lupus erythematosus (SLE). | [
"12670680"
] | [
"BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS. In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes t... |
280 | Comparative transcriptome analysis identified new platelet proteins with structural features suggesting a role in platelet function. | [
"25001628"
] | [
"Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.. To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblast... |
281 | Concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines are distinct from their founding cells. | [
"4632921"
] | [
"Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells.. In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants assoc... |
283 | Consumption of whole fruits increases the risk of type 2 diabetes. | [
"1974176"
] | [
"Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. OBJECTIVE To determine whether individual fruits are differentially associated with risk of type 2 diabetes. DESIGN Prospective longitudinal cohort study. SETTING Health professionals in the United States. PA... |
285 | Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact. | [
"5548081"
] | [
"Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic.. CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human... |
286 | Converting apoE4 to apoE3 by gene editing prevents the pathology associated with apoE4 in human iPSCderived neurons. | [
"4709641"
] | [
"Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Usin... |
287 | Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons. | [
"4709641"
] | [
"Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Usin... |
290 | Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice. | [
"15048300"
] | [
"A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example. BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of th... |
292 | Cost effectiveness evaluations based on cRCT data lack external validity. | [
"15048300"
] | [
"A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example. BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of th... |
293 | Crossover hot spots are found within gene promoters in Saccharomyces cerevisiae. | [
"10874408"
] | [
"Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae. DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break pro... |
296 | Cyclin A2 destruction is necessary to switch from unstable to stable kt-mt attachments in mitosis. | [
"4398832"
] | [
"Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation. The most conspicuous event in the cell cycle is the alignment of chromosomes in metaphase. Chromosome alignment fosters faithful segregation through the formation of bi-oriented attachments of kinetochores to spindle microtubul... |
299 | Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis. | [
"39381118"
] | [
"At the gates of death.. Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential step is controlled and mediated by proteins of the Bcl... |
30 | A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome. | [
"24341590"
] | [
"Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.. CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. ... |
301 | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1. | [
"3553087"
] | [
"Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice. Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptib... |
304 | DMS3 protein enables Pol V transcription in vivo. | [
"14797520"
] | [
"Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes. Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding tra... |
305 | DRD1 proteins enable Pol V transcription in vivo. | [
"14797520"
] | [
"Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes. Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding tra... |
306 | DUSP4 decreases apoptosis. | [
"7821634"
] | [
"Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, wh... |
308 | DUSP4 downregulation deactivates the Ras-ERK pathway | [
"7821634"
] | [
"Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, wh... |
309 | DUSP4 increases apoptosis. | [
"7821634"
] | [
"Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, wh... |
310 | De novo assembly of sequence data has fewer specific contigs than unassembled sequence data. | [
"6173523"
] | [
"A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.. IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particula... |
313 | De novo assembly of sequence data has shorter contigs than unassembled sequence data. | [
"6173523"
] | [
"A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.. IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particula... |
315 | Decrease of p62 in prostate tumor stroma results in defective autophagy. | [
"3701541"
] | [
"p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.. Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis. We found th... |
316 | Decreased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE. | [
"712078"
] | [
"Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice. Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport. ... |
317 | Decreased diastolic blood pressure (DBP) is associated with abdominal aortic aneurysm. | [
"4506414"
] | [
"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not bee... |
32 | A country's Vaccine Alliance (GAVI) eligibility is not indictivate of accelerated adoption of the Hub vaccine. | [
"12428497"
] | [
"Accelerating Policy Decisions to Adopt Haemophilus influenzae Type b Vaccine: A Global, Multivariable Analysis. BACKGROUND Adoption of new and underutilized vaccines by national immunization programs is an essential step towards reducing child mortality. Policy decisions to adopt new vaccines in high mortality cou... |
323 | Deleting Raptor increases G-CSF levels. | [
"2014909"
] | [
"Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanism... |
325 | Deletion of ATM and Rad3 related protein is not predictive of acute tissue loss. | [
"40349336"
] | [
"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in ... |
326 | Deletion of ATM and Rad3 related protein leads to acute tissue loss. | [
"40349336"
] | [
"Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in ... |
330 | Deltex has no known interactions with eIF3f. | [
"9505448"
] | [
"The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation. Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-s... |
331 | Deltex interacts with eIF3. There is no known interaction between Deltex and elF3 | [
"9505448"
] | [
"The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation. Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-s... |
332 | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection decreases dissemination of Salmonella Typhimurium from the gut. | [
"29023309"
] | [
"Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immuno... |
333 | Depletion of T-helper 17 (Th17) cells during simian immunodeficiency virus (SIV) infection increases dissemination of Salmonella Typhimurium from the gut. | [
"29023309"
] | [
"Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immuno... |
334 | Depletion of nitric oxide is responsible for vasospasm. | [
"25079962"
] | [
"Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.. CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for ruptured intracranial aneurysm. Decreased bioavailabili... |
335 | Deregulation of HAND2 is a crucial step in endometrial carcinogenesis in mice. | [
"1780819"
] | [
"Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development. BACKGROUND Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Acc... |
336 | Destination container port throughput(CPT) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
"2097256"
] | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... |
337 | Destination container port throughput(CPT) is positively related to dengue virus (DENV-1) diffusion in air traffic shipments. | [
"2097256"
] | [
"Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We ... |
339 | Dexamethasone increases risk of postoperative bleeding. | [
"23349986"
] | [
"Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial.. CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric tonsillectomy. OBJECTIVE To assess whether dexamethasone dose-dependently reduces the ... |
34 | A deficiency of folate increases blood levels of homocysteine. | [
"11705328"
] | [
"Randomized trial of folic acid supplementation and serum homocysteine levels.. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (re... |
340 | Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | [
"7098463"
] | [
"Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.. CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJECTIVE To determine if surgically induced weight loss results in better glycemic con... |
341 | Diabetes remission occurs more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | [
"7098463"
] | [
"Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.. CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJECTIVE To determine if surgically induced weight loss results in better glycemic con... |
342 | Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | [
"7873737",
"5884524"
] | [
"Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.. BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this disease may be associated with increased platelet aggr... |
345 | Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis. | [
"4394817"
] | [
"E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells. In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariabl... |
346 | Differentiation of progenitor cells to myeloid cells is skewed upon activation of insulin signaling. | [
"11902109"
] | [
"Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila. The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocyte... |
347 | Differentiation of progenitor cells to myeloid cells is skewed when insulin signaling is suppressed. | [
"11902109"
] | [
"Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila. The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocyte... |
349 | Diminished ovarian reserve is a reliable indicator of infertility in a non-infertile population. | [
"13497630"
] | [
"Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age. Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective To determine the associations between biomarkers ... |
35 | A deficiency of vitamin B12 decreases blood levels of homocysteine. | [
"5152028",
"11705328"
] | [
"Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering.. BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the ... |
351 | Distant CREs are important for transcriptional regulation. | [
"14658685"
] | [
"Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian s... |
352 | Distant CREs are less conserved among species. | [
"14658685"
] | [
"Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian s... |
355 | Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs. | [
"12800122",
"38380061"
] | [
"Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary. Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between compartments can result in local expression of secreted... |
356 | Dscam1 acts as a hypervariable pattern-recognition receptor for the immune system. | [
"6144337"
] | [
"AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System . Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here... |
357 | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks. | [
"18111172"
] | [
"The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining. Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this ques... |
358 | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks. | [
"18111172"
] | [
"The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining. Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this ques... |
361 | During the primary early antibody response activated B cells migrate toward the inner-and outer follicular areas where oxysterol accumulation is generated by stromal cells. | [
"38587347"
] | [
"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.. Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high... |
363 | EG7 tumors can be killed by systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells. | [
"5386514"
] | [
"Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors. The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lympho... |
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