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A 2-year follow-up study of patients with pharyngotonsillitis | BACKGROUND: Longtime follow-up studies on patients with pharyngotonsillitis are rare. We aimed to describe the patterns of new visits for a sore throat, complications and tonsillectomy during 2 years in a cohort of patients with pharyngotonsillitis and non-infected controls. METHODS: A retrospective chart review was pe... |
Chilblain y lesiones purpúricas acrales en COVID-19 | |
Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems | To reveal the putative cellular factors involved in SARS coronavirus replication, the helicase (Hel, nsp13) of SARS coronavirus was used to screen the cDNA library of rat pulmonary epithelial cells using the yeast two-hybrid system. Positively interacting proteins were further tested using a mammalian cell hybrid syste... |
Choroid plexus and the blood–cerebrospinal fluid barrier in disease | The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lini... |
LIPS method for the detection of SARS‐CoV‐2 antibodies to spike and nucleocapsid proteins | Profiling antibodies to SARS‐CoV‐2 can help to assess potential immune response after COVID‐19 disease. Luciferase IP system (LIPS) assay is a sensitive method for quantitative detection of antibodies to antigens in their native conformation. We here describe LIPS to detect antibody responses to SARS‐CoV‐2 spike (S) an... |
Hospitalization due to human parainfluenza virus–associated lower respiratory tract illness in rural Thailand | Background Human parainfluenza viruses (HPIVs) are an important cause of acute respiratory illness in young children but little is known about their epidemiology in the tropics. Methods From 2003–2007, we conducted surveillance for hospitalized respiratory illness in rural Thailand. We performed reverse‐transcriptase p... |
Distinct infection process of SARS‐CoV‐2 in human bronchial epithelial cells line | COVID‐19, caused by SARS‐CoV‐2, leads to a series of clinical symptoms of respiratory and pulmonary inflammatory reactions via unknown pathologic mechanisms related to the viral infection process in tracheal or bronchial epithelial cells. Investigation of this viral infection in the human bronchial epithelial cell line... |
Tissue Distribution of the MERS-Coronavirus Receptor in Bats | Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor. The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism. Apart from dromedary camels, insectivorous bats... |
Sequence of the 3′ end of the simian hemorrhagic fever virus genome | SHFV is a member of a new virus family which includes the genus arterivirus. We have cloned and sequenced 6,314 nt from the 3′ end of the SHFV genome. This sequence encompasses nine complete ORFs which is three additional ORFs as compared to the other arteriviruses. We have numbered these ORFs 2a, 2b, 3, 4, 5, 6, 7, 8 ... |
Food safety risk during the pandemic | |
Correlation analysis of the severity and clinical prognosis of 32 cases of patients with COVID-19 | • Fibrosis indicators were early warning markers for critical COVID-19 patients. • Dynamic changes of lymphocyte count and CRP levels were related to the prognosis. • Rapid pulmonary consolidation was the major feature for died COVID-19 patients. • Pathological changes included inflammatory exudation and formation of g... |
Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19 | |
Review and analysis of current responses to COVID-19 in Indonesia: Period of January to March 2020 | Abstract The world is under pressure from the novel COVID-19 pandemic. Indonesia is the fourth most populous country in the world and predicted to be affected significantly over a longer time period. Our paper aims to provide detailed reporting and analyses of the present rapid responses to COVID-19, between January an... |
BSPD issues plea to parents during lockdown | |
Infección por SARS-CoV-2: implicaciones para la salud sexual y reproductiva. Una declaración de posición de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA) | OBJECTIVE: The main objective of this revision is to summarize the current existing evidence of the potential adverse effects of SARS-CoV-2 on the male reproductive system and provide the recommendations of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA) concerning the implications of COVI... |
Carry forward advantages of traditional medicines in prevention and control of outbreak of COVID-19 pandemic | Members of the China-ASEAN Joint Laboratory for International Cooperation in Traditional Medicine Research used the video conference platform to exchange and discuss the advantages of traditional medicine through the form of score exchange and report, and research and develop the amount and issues of the therapeutic CO... |
Occurrence of Acute Pulmonary Embolism in COVID-19 – A Case Series | |
Rapid one-step construction of a Middle East Respiratory Syndrome (MERS-CoV) infectious clone system by homologous recombination | Abstract Background Viral Infectious clone systems serve as robust platforms to study viral gene or replicative function by reverse genetics, formulate vaccines and adapt a wild type-virus to an animal host. Since the development of the first viral infectious clone system for the poliovirus, novel strategies of viral g... |
The personality types of key catalytic individuals shape colonies' collective behaviour and success | Behavioural ecologists often note that one or a few group members appear to shape the collective behaviour of social groups differentially. Our understanding of these keystone individuals is largely taken from meticulous field observations and semi-scientific anecdotes. In this study we experimentally test whether the ... |
Chapter 6 Defensins and Other Antimicrobial Peptides and Proteins | |
On the basic reproduction number and the topological properties of the contact network: An epidemiological study in mainly locally connected cellular automata | Abstract We study the spreading of contagious diseases in a population of constant size using susceptible-infective-recovered (SIR) models described in terms of ordinary differential equations (ODEs) and probabilistic cellular automata (PCA). In the PCA model, each individual (represented by a cell in the lattice) is m... |
Infection Prevention in Transplantation | The number of patients undergoing hematopoietic cell and solid organ transplantation are increasing every year, as are the number of centers both transplanting and caring for these patients. Improvements in transplant procedures, immunosuppressive regimens, and prevention of transplant-associated complications have led... |
Emergency department triage: an ethical analysis | BACKGROUND: Emergency departments across the globe follow a triage system in order to cope with overcrowding. The intention behind triage is to improve the emergency care and to prioritize cases in terms of clinical urgency. DISCUSSION: In emergency department triage, medical care might lead to adverse consequences lik... |
MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis | Infection of the CNS (central nervous system) with a sublethal neurotropic coronavirus (JHMV) induces a vigorous inflammatory response. CD4(+) and CD8(+) T cells are essential to control infectious virus but at the cost of tissue damage. An enigma in understanding the contribution of T cell subsets in pathogenesis resi... |
Migratory Pulmonary Infiltrates in a Patient with COVID-19 Infection and the Role of Corticosteroids | |
First retrospective studies with etiological confirmation of porcine transmissible gastroenteritis virus infection in Argentina | BACKGROUND: In 2014, a notification of porcine transmissible gastroenteritis virus (TGEV) was made by the National Services of Animal Health of Argentina (SENASA) to the World Organization of Animal Health (OIE). The notification was based on a serological diagnosis in a small farm with a morbidity rate of 2.3% without... |
COVID-19 in Rheumatic Disease Patients on Immunosuppressive Agents | OBJECTIVE: To analyze clinical characteristics and outcome of COVID-19 patients with underlying rheumatic diseases (RD) on immunosuppressive agents. METHOD: A case series of COVID-19 patients with RD on disease modifying anti-rheumatic drugs (DMARDs) were studied by a retrospective chart review. A literature search ide... |
Legionnaires' disease mimicking swine influenza (H1N1) pneumonia during the “herald wave” of the pandemic | Background New York area hospitals were hit hard by the swine influenza (H1N1) pandemic in spring and summer 2009. During a pandemic, the initial cases may be difficult to recognize, but subsequent clinical diagnoses were relatively straightforward, given the high volume of cases and their typical clinical presentation... |
Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease | Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta (SNPC) and the striatum. Nuclear receptor-related 1 protein (Nurr1) is a nuclear hormone receptor implicated in limiting mitochondrial dysfunction, apoptosis, and inflammation in the central nervous system and ... |
World Health Organization | The World Health Organization is the global authority on health issues. Since its inception in 1948, it has made large strides in advancing its goal of the highest attainable level of health for all people. Through the years, the organization has faced many setbacks, but it has also marked numerous achievements. The gl... |
Air quality changes during the COVID-19 lockdown over the Yangtze River Delta Region: An insight into the impact of human activity pattern changes on air pollution variation | Abstract The outbreak of COVID-19 has spreaded rapidly across the world. To control the rapid dispersion of the virus, China has imposed national lockdown policies to practise social distancing. This has led to reduced human activities and hence primary air pollutant emissions, which caused improvement of air quality a... |
Functional recombinant human anti-HAV antibody expressed in milk of transgenic mice | Hepatitis A virus (HAV) is a wide spread pathogenic agent and is the common cause of acute Hepatitis A worldwide. Passive immunization of HAV plays an extremely important role in post-exposure prophylaxis with clinical applications often requiring large amounts of antibody. As an alternative to the in vitro production ... |
Efficacy of Listerine(®) Antiseptic in reducing viral contamination of saliva | Aim: The anti‐viral efficacy of oral antimicrobial rinses has not been adequately studied in terms of potential clinical significance. As a follow‐up to an in vitro study on the effect of oral antiseptics on Herpes simplex virus, Type 1, this study was undertaken to evaluate the in vivo effect of an essential oil conta... |
VirOligo: a database of virus-specific oligonucleotides | VirOligo is a database of virus-specific oligonucleotides. The VirOligo database consists of two tables, Common data and Oligo data. The Oligo data table contains PCR primers and hybridization probes used for detection of viral nucleic acids and the Common data table contains the experimental conditions used in their d... |
Changes in the Prevalence of HBsAg and HBeAg: a Study of 8696 Parturients in a Well Vaccinated Area | To elucidate the impact of a hepatitis B (HB) vaccination program on the prevalence of HB surface antigen (HBsAg) and HB envelope antigen (HBeAg) as well as the success rate of HBeAg clearance among parturients, we collected data on parturients who gave birth between 2000 and 2010, and recorded the HB status postpartum... |
Coronovirus infection as a novel delusional topic | Abstract Delusional topics tend to rapidly incorporate popular hot topical issues. Thus, the current coronavirus COVID-19 pandemic has rapidly reached delusional themes in patients with psychiatric disorders. Here we present the clinical case of a Spanish woman with bipolar disorder that included coronavirus infection ... |
3 vragen over De Covid-19 Verhalenbank | Wie: Hugo Schalkwijk (28), adviseur Historisch College Florence Nightingale Instituut (FNI) |
iSNO-AAPair: incorporating amino acid pairwise coupling into PseAAC for predicting cysteine S-nitrosylation sites in proteins | As one of the most important and universal posttranslational modifications (PTMs) of proteins, S-nitrosylation (SNO) plays crucial roles in a variety of biological processes, including the regulation of cellular dynamics and many signaling events. Knowledge of SNO sites in proteins is very useful for drug development a... |
Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes | The severe acute respiratory syndrome coronavirus (SARS-CoV) envelope spike (S) glycoprotein is responsible for the fusion between the membranes of the virus and the target cell. In the case of the S2 domain of protein S, it has been found a highly hydrophobic and interfacial domain flanked by the heptad repeat 1 and 2... |
Real-time assessment of COVID-19 prevalence among multiple sclerosis patients: a multicenter European study | We assessed the prevalence and impact of COVID-19 among multiple sclerosis (MS) patients across Europe by leveraging participant data collected as part of the ongoing EU IMI2 RADAR-CNS major programme aimed at finding new ways of monitoring neurological disorders using wearable devices and smartphone technology. In the... |
Responsible Return to Essential and Non-Essential Surgery During the COVID-19 Pandemic | Non-essential surgery had largely been suspended during the COVID-19 Pandemic. Enormous amounts of resources were utilized to shift surgical practices to a “disaster footing” with most elective surgeons assuming new roles to offset the anticipated burden from surgical and medical personnel delivering acute care. As the... |
COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period | Little is known about surgical practice in the initial phase of coronavirus disease 2019 (COVID-19) global crisis. This is a retrospective case series of 4 surgical patients (cholecystectomy, hernia repair, gastric bypass, and hysterectomy) who developed perioperative complications in the first few weeks of COVID-19 ou... |
The phosphorylation of the N protein could affect PRRSV virulence in vivo | Abstract The porcine respiratory and reproductive syndrome virus (PRRSV) nucleocapsid (N) protein is a multiphosphorylated protein.It has been proved that the phosphorylation of N protein could regulate the growth ability of PRRSV in Marc-145 cells. However, further investigation is needed to determine whether phosphor... |
The Covid-19 Pandemic and People with Disability | |
Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD? | BACKGROUND: The SARS-CoV-2 virus continues to spread rapidly across the globe afflicting many with Coronavirus Disease 2019 (COVID-19). As the infection rates rise, a growing number of SARS-CoV-2 positive individuals have been reported to complain of olfactory disturbances at an alarming rate. Postviral olfactory dysfu... |
Disidratazione acuta nel lattante | Il lattante al di sotto di un anno, e soprattutto al di sotto di sei mesi, è ad alto rischio di disidratazione, di cui la prima causa è la diarrea. Questa è principalmente di origine virale. La gestione di una disidratazione comporta la correzione di questa e il soddisfacimento delle richieste idriche e nutrizionali. L... |
Deoxynivalenol Promotes Porcine Epidemic Diarrhea Virus Infection and Aggravates Gut Barrier Injury | Porcine epidemic diarrhea virus (PEDV) is a highly contagious pathogenic virus that causes severe diarrhea and dehydration in pigs of all ages. Deoxynivalenol (DON), the most abundant trichothecene in food and feed, causes vomit and diarrhea in animals and human. However, whether DON exposure could affect PEDV infectio... |
Automated degenerate PCR primer design for high-throughput sequencing improves efficiency of viral sequencing | BACKGROUND: In a high-throughput environment, to PCR amplify and sequence a large set of viral isolates from populations that are potentially heterogeneous and continuously evolving, the use of degenerate PCR primers is an important strategy. Degenerate primers allow for the PCR amplification of a wider range of viral ... |
The incidence and management of persistent cystoid macular oedema following uncomplicated cataract surgery—a Scottish Ophthalmological Surveillance Unit study | PURPOSE: Post-operative cystoid macular oedema (CMO) can cause deterioration of vision following routine cataract surgery. The incidence of persistent CMO (pCMO; defined as CMO present after 3 months) following uncomplicated surgery is uncertain. We wished to identify the incidence, management and visual outcomes of su... |
Prevalence and Pathogenicity of WU and KI Polyomaviruses in Children, the Netherlands | A longitudinal study in 2004 and 2005 detected polyomaviruses WU and KI in 44% and 17% of children with and without respiratory symptoms, respectively, in the Netherlands. In some children both viruses were detected for long periods. In several symptomatic children no other respiratory pathogen was detected. |
Web-based forecasting system for the airborne spread of livestock infectious disease using computational fluid dynamics | Livestock infectious diseases, such as foot-and-mouth disease (FMD), cause substantial economic damage to livestock farms and their related industries. Among various causes of disease spread, airborne dispersion has previously been considered to be an important factor that could not be controlled by preventive measures... |
Emerging Issues for the Public Health Laboratory | |
Living donor liver transplants for sick recipients during COVID‐19 pandemic‐ An experience from a tertiary center in India | The recent outbreak of COVID‐19 has brought elective surgeries including liver transplantation to a standstill. The concerns in Living Donor Liver Transplant (LDLT) were that immunosuppressed recipients and healthy donors would be exposed to nosocomial SARS‐ CoV‐2 infection.(1) However, as patients began to suffer and ... |
COVID-19 in solid organ transplantation patients: A systematic review | Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients. We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-... |
Efficacy of an automated multi-emitter whole room UV-C disinfection system against Coronaviruses MHV and MERS-CoV | The virus responsible for Middle Eastern respiratory syndrome, MERS-CoV is a lineage C betacoronavirus similar to the mouse hepatitis virus type A59 (MHV-A59). The first reported case of MERS occurred in Saudi Arabia in 2012 and resulted in 76 deaths(1). Outbreaks of MERS have since occurred not only in the Middle East... |
Rapid discrimination of oseltamivir‐resistant 275Y and ‐susceptible 275H substitutions in the neuraminidase gene of pandemic influenza A/H1N1 2009 virus by duplex one‐step RT‐PCR assay | Pandemic influenza A/H1N1 2009 (A/H1N1pdm) virus caused significant outbreaks worldwide last year (2009). A number of oseltamivir‐resistant A/H1N1pdm viruses possessing an H275Y substitution in the neuraminidase (NA) protein were reported sporadically in several countries, including Japan, but they were sensitive to za... |
Sentiment analysis of Social Media Response on the Covid19 outbreak | |
Early evolution and the origin of eukaryotes | |
Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein function | Abstract Severe acute respiratory syndrome virus (SARS-CoV) was the causative agent of the SARS outbreaks in 2002–2003. A safer in vitro system is desirable for conducting research on SARS-CoV and to screen for antiviral drugs against the virus. Based on the infectious cDNA clone of rSARS-CoV-ΔE, in which the E gene ha... |
Characterization of Human Coronavirus Etiology in Chinese Adults with Acute Upper Respiratory Tract Infection by Real-Time RT-PCR Assays | BACKGROUND: In addition to SARS associated coronaviruses, 4 non-SARS related human coronaviruses (HCoVs) are recognized as common respiratory pathogens. The etiology and clinical impact of HCoVs in Chinese adults with acute upper respiratory tract infection (URTI) needs to be characterized systematically by molecular d... |
A Comparative Process Mining Analysis of Road Trauma Patient Pathways | In this paper we report on key findings and lessons from a process mining case study conducted to analyse transport pathways discovered across the time-critical phase of pre-hospital care for persons involved in road traffic crashes in Queensland (Australia). In this study, a case is defined as being an individual pati... |
Nosocomial outbreak of COVID-19 pneumonia in Wuhan, China | BACKGROUND: The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infected over 3300 healthcare workers in early 2020 in China. Little information is known about nosocomial infections of healthcare workers in the initial period. We analysed data from healthcare workers with nosocomial inf... |
Phosphorylation and membrane association of the Rubella virus capsid protein is important for its anti‐apoptotic function | Rubella virus (RV), a member of Togaviridae, is an important human pathogen that can cause severe defects in the developing fetus. Compared to other togaviruses, RV replicates very slowly suggesting that it must employ effective mechanisms to delay the innate immune response. A recent study by our laboratory revealed t... |
“Runde“ virus, a coronavirus-like agent associated with seabirds and ticks | From 206I. uriae collected in the seabird colonies at Runde, Norway, two identical virus strains demonstrating no antigenic relationships to major arbovirus groups were isolated. The new strains demonstrated a corona-virus like morphology, haemagglutinated chicken red cells and were sensitive to sodium desoxycholate. M... |
Deep learning system to screen coronavirus disease 2019 pneumonia | Radiographic patterns on CT chest scans have shown higher sensitivity and specificity compared to RT-PCR detection of COVID-19 which, according to the WHO has a relatively low positive detection rate in the early stages. We technically review a study that compared multiple convolutional neural network (CNN) models to c... |
Healthcare Settings as Amplifiers of Infectious Disease | |
Hypolipidemia is associated with the severity of COVID-19 | Abstract Background Many patients with coronavirus disease 2019 (COVID-19) suffer multiple organ dysfunctions. However, whether patients develop dyslipidemia is unknown. Objective In this study, we aimed to investigate the pathological alterations of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein... |
The macrodomain family: Rethinking an ancient domain from evolutionary perspectives | The reasons why certain domains evolve much slower than others is unclear. The notion that functionally more important genes evolve more slowly than less important genes is one of the few commonly believed principles of molecular evolution. The macro-domain (also known as the X domain) is an ancient, slowly evolving an... |
Skin amidst COVID‐19 pandemic | |
Niclosamide Blocks Rice Leaf Blight by Inhibiting Biofilm Formation of Xanthomonas oryzae | Rice (Oryza sativa) is the leading source of nutrition for more than half of the world’s population, and by far it is the most important commercial food crop. But, its growth and production are significantly hampered by the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo) which causes leaf blight disease. Earlier... |
High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea | Summary Background Effective countermeasures against emerging infectious diseases require an understanding of transmission rate and basic reproduction number (R 0). R 0 for severe acute respiratory syndrome is generally considered to be >1, whereas that for Middle East respiratory syndrome (MERS) is considered to be <1... |
Diabetes and COVID-19: IDF perspective in the Western Pacific Region | Abstract The World Health Organization (WHO) declared a pandemic, the highest risk level in the infectious disease alert phase, on 11 March 2020. In the Western Pacific Region (WPR), 192,016 confirmed cases with 7,125 deaths had been reported as of 8 June 2020. In people with diabetes COVID-19 can be more difficult to ... |
Porcine reproductive and respiratory syndrome virus (PRRSV) up-regulates IL-8 expression through TAK-1/JNK/AP-1 pathways | Abstract The acute phase of respiratory distress caused by porcine reproductive and respiratory syndrome virus (PRRSV) is likely a consequence of the release of inflammatory cytokines in the lung. IL-8, the main chemokine and activator of neutrophils, might be related to the lung injury upon PRRSV infection. In this st... |
Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study | INTRODUCTION: The aetiology of acute exacerbations of chronic obstructive pulmonary disease (COPD) remains incompletely understood and strategies for treatment and prevention have not altered significantly for many years. Improved understanding of the role of respiratory pathogens in acute exacerbations of COPD (AECOPD... |
Chilblain‐like lesions on feet and hands during the COVID‐19 Pandemic | |
The history of monoclonal antibody development – Progress, remaining challenges and future innovations | As medicine progresses into a new era of personalised therapy, the use of monoclonal antibodies to treat a wide range of diseases lies at the heart of this new forefront. Since the licencing of the first monoclonal antibody for clinical use 30 years ago, the monoclonal antibody industry has expanded exponentially and i... |
Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects | Abstract Nucleic acids carry the building plans of living systems. As such, they can be exploited to make cells produce a desired protein, or to shut down the expression of endogenous genes or even to repair defective genes. Hence, nucleic acids are unique substances for research and therapy. To exploit their potential... |
Astroviruses☆ | Abstract Astroviruses are positive-sense, single-stranded RNA viruses. Their genomes contain three open reading frames, but the exact number of encoded proteins remains unknown. Astroviruses were originally identified in association with childhood diarrhea; subsequently, they have been identified as a common enteric vi... |
A dynamic model for the p53 stress response networks under ion radiation | P53 controls the cell cycle arrest and cell apoptosis through interaction with the downstream genes and their signal pathways. To stimulate the investigation into the complicated responses of p53 under the circumstance of ion radiation (IR) in the cellular level, a dynamic model for the p53 stress response networks is ... |
Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes | BACKGROUND: Cyrtomium fortumei (J.) Smith is an important Chinese herbal medicine because of its biological functions. However, systematic and comprehensive studies on the phytochemicals from Cyrtomium fortumei (J.) Smith and their bioactivity are limited. RESULTS: Using the bioassay-guided technique, the ethyl acetate... |
Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 | BACKGROUND: H7N9 continues to cause human infections and remains a pandemic concern. Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation, including infectious disease prevention and control investment. However, there are limited data on such impacts. ... |
Tracheotomy in COVID‐19 patients: preliminary experience and technical refinements | |
Fourth European Conference on Infections in Leukaemia (ECIL-4): Guidelines for Diagnosis and Treatment of Human Respiratory Syncytial Virus, Parainfluenza Virus, Metapneumovirus, Rhinovirus, and Coronavirus | Community-acquired respiratory virus (CARV) infections have been recognized as a significant cause of morbidity and mortality in patients with leukemia and those undergoing hematopoietic stem cell transplantation (HSCT). Progression to lower respiratory tract infection with clinical and radiological signs of pneumonia ... |
Chilblains‐like dermatologic manifestation of COVID‐19 diagnosed by serology via multidisciplinary virtual care | |
Chronique d’une kinésithérapeute à l’heure de la Covid-191 | Résumé Ce récit témoigne du vécu de l’épidémie à l’heure de la Covid-19, par l’auteur masseur-kinésithérapeute en service hospitalier et en libéral. Après un descriptif de son expérience dans les différentes dimensions de sa vie, professionnelle et personnelle, l’auteur éclaire son ressenti de notions psychologiques et... |
Antibiotic Discontinuation Rates Associated with Positive Respiratory Viral Panel and Low Procalcitonin Results in Proven or Suspected Respiratory Infections | INTRODUCTION: The differentiation of viral from bacterial pneumonia is important in determining whether antibiotics are appropriate for treatment of these infections. Advances in diagnostic technologies such as respiratory panels (RP) utilizing polymerase chain reactions to detect viruses and determination of procalcit... |
Accumulating evidence for a role of oxidized phospholipids in infectious diseases | Oxidized phospholipids (OxPL) were originally discovered as by-products and mediators of chronic inflammation such as in atherosclerosis. Over the last years, an increasing body of evidence led to the notion that OxPL not only contribute to the pathogenesis of chronic inflammatory processes but in addition play an inte... |
SARS-CoV Genome Polymorphism: A Bioinformatics Study | A dataset of 103 SARS-CoV isolates (101 human patients and 2 palm civets) was investigated on different aspects of genome polymorphism and isolate classification. The number and the distribution of single nucleotide variations (SNVs) and insertions and deletions, with respect to a “profile”, were determined and discuss... |
Disordered Residues and Patterns in the Protein Data Bank | We created a new library of disordered patterns and disordered residues in the Protein Data Bank (PDB). To obtain such datasets, we clustered the PDB and obtained the groups of chains with different identities and marked disordered residues. We elaborated a new procedure for finding disordered patterns and created a ne... |
Protective Effects of Long Pentraxin PTX3 on Lung Injury in a Severe Acute Respiratory Syndrome Model in Mice | The outbreak of severe acute respiratory syndrome (SARS) in 2003 reinforces the potential of lethal pandemics of respiratory viral infection s. The underlying mechanisms of SARS are still largely undefined. Long pentraxin PTX3, a humoral mediator of innate immunity, has been reported to have anti-viral effects. We exam... |
Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion | |
Optimising Lockdown Policies for Epidemic Control using Reinforcement Learning: An AI-Driven Control Approach Compatible with Existing Disease and Network Models | There has been intense debate about lockdown policies in the context of Covid-19 for limiting damage both to health and to the economy. We present an AI-driven approach for generating optimal lockdown policies that control the spread of the disease while balancing both health and economic costs. Furthermore, the propos... |
The cytokine storm of severe influenza and development of immunomodulatory therapy | Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are often associated with hyperinduction of proinflammatory cytokine production, which is also known as ‘cytokine storm'. For this disease, it has been proposed that immunomodulatory therapy may... |
Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs | Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental and sexual human-to-human transmission. Although the pathogenesis of ZIKV-associated neurological complications has been reported in recent studies, key questions on the pathogenesis of the o... |
Respiratory Infections during SARS Outbreak, Hong Kong, 2003 | The effect of community hygienic measures during the outbreak of severe acute respiratory syndrome in Hong Kong was studied by comparing the proportion of positive specimens of various respiratory viruses in 2003 with those from 1998 to 2002. Community hygienic measures significantly reduced the incidence of various re... |
Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors | The SARS-CoV-2 is the causative agent of COVID-19 pandemic that is causing a global health emergency. The lack of targeted therapeutics and limited treatment options have triggered the scientific community to develop new vaccines or small molecule therapeutics against various targets of SARS-CoV-2. The main protease (M... |
China’s Internationalized Higher Education During Covid-19: Collective Student Autoethnography | This article presents 15 autoethnographical texts detailing student experiences at Beijing Normal University in the midst of the Covid-19 pandemic. Contributions have been collected over 6 weeks between 15 February and 1 April 2020, edited by Hejia Wang (assisted by Moses Oladele Ogunniran and Yingying Huang), and supe... |
Mechanism of measles virus failure to activate NF-κB in neuronal cells | Lack of IFN-β and MHC class I expression in measles virus (MV) infected neurons could impair the host antiviral defense mechanism and result in virus escape from recognition by cytotoxic T-cells. Induction of IFN-β and MHC class I gene expression requires NF-κB activation which depends on degradation of IκBα, an inhibi... |
Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway | Programmed −1 ribosomal frameshift (−1 PRF) signals redirect translating ribosomes to slip back one base on messenger RNAs. Although well characterized in viruses, how these elements may regulate cellular gene expression is not understood. Here we describe a −1 PRF signal in the human mRNA encoding CCR5, the HIV-1 co-r... |
Development and Implementation of Multiplex TaqMan Array Cards for Specimen Testing at Child Health and Mortality Prevention Surveillance Site Laboratories | Child Health and Mortality Prevention Surveillance (CHAMPS) laboratories are employing a variety of laboratory methods to identify infectious agents contributing to deaths of children <5 years old and stillbirths in sub-Saharan Africa and South Asia. In support of this long-term objective, our team developed TaqMan Arr... |
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