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Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong | Many new infectious diseases in humans have been derived from animal sources in the past 20 years. Some are highly contagious and fatal. Vaccination may not be available and antiviral drugs are not effective enough. Infectious control is important in clinical medicine and in Ophthalmology. Severe acute respiratory synd... |
Retrospective analysis assessing the spatial and temporal distribution of paediatric acute respiratory tract infections in Ho Chi Minh City, Vietnam | BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution, temporal trends and climatic risk factors of paediatric ARIs in Vietnam. METHODS: Data from ... |
Respiratory protection policies and practices among the health care workforce exposed to influenza in New York State: Evaluating emergency preparedness for the next pandemic | BACKGROUND: New York State hospitals are required to implement a respiratory protection program (RPP) consistent with the Occupational Safety and Health Administration respirator standard. Guidance provided during the 2009 novel H1N1 pandemic expanded on earlier recommendations, emphasizing the need to keep staff in al... |
Lesiones musculoesqueléticas secundarias al ejercicio durante el confinamiento por la pandemia covid-19 | |
Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors | Enveloped viruses gain entry into host cells by fusing with cellular membranes, a step required for virus replication. Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and infectious bronchitis virus (IBV), fuse at the plasma... |
Nuclear cardiology in the COVID-19 pandemic era | Summary The current coronavirus disease 2019 (COVID-19) pandemic has important implications for the cardiovascular care of patients. Implementation of a robust plan in nuclear cardiology units is required to prevent further nosocomial spread of the outbreak. This editorial covers the practical advice on how to protect ... |
Taking the bull by the horns: Ethical considerations in the design and implementation of an Ebola virus therapy trial | Abstract Ebola virus is categorized as one of the most dangerous pathogens in the world. Although there is no known cure for Ebola virus, there is some evidence that the severity of the disease can be curtailed using plasma from survivors. Although there is a general consensus on the importance of research, methodologi... |
China coronavirus: Hong Kong health staff strike to demand border closure as city records first death. | |
Endemic infection can shape exposure to novel pathogens: Pathogen co‐occurrence networks in the Serengeti lions | Pathogens are embedded in a complex network of microparasites that can collectively or individually alter disease dynamics and outcomes. Endemic pathogens that infect an individual in the first years of life, for example, can either facilitate or compete with subsequent pathogens thereby exacerbating or ameliorating mo... |
Update: Severe Respiratory Illness Associated With a Novel Coronavirus—Worldwide, 2012-2013 | |
Publishing in face of the COVID-19 pandemic | |
Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors | The envelope glycoproteins GP1 and GP2 of Lassa virus (LASV) bind to the host cell receptors to mediate viral infection. So far, no approved vaccines and specific treatment options against LASV exist. To develop specific fusion inhibitors against LASV, we solved the crystal structure of the post-fusion 6 helix bundle (... |
Amantadine resistance among influenza A isolates in Sweden 2001–2006 | |
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein | The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response. We show he... |
EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication | Abstract Transmissible gastroenteritis coronavirus (TGEV) is an enteropathogenic coronavirus that causes diarrhea in pigs, which is correlated with high morbidity and mortality in suckling piglets. Using the method of GST pull-down with the nucleocapsid (N), N protein was found to interact with swine testes (ST) cells ... |
The YXXΦ motif within the severe acute respiratory syndrome coronavirus (SARS-CoV) 3a protein is crucial for its intracellular transport | BACKGROUND: The SARS coronavirus (SARS-CoV) 3a protein functions as an ion channel, induces apoptosis and is important for viral pathogenesis. It is expressed on the cell surface and contains a tyrosine-based sorting motif and a di-acidic motif, which may be crucial for its intracellular trafficking. However the role o... |
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors | The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine proteases. The isolated compounds were broussochalcone B (1), broussochalcone A (2), 4-hydroxyisolonchocarpin (3), papyriflavonol A (4), 3′-(3-... |
Histologic features of long lasting chilblain‐like lesions in a pediatric COVID‐19 patient | Since the beginning of the pandemic of Coronavirus disease (COVID‐19) an increasing number of skin manifestations have been reported.(1,2) Most reports concern adult patients and describe various patterns of skin eruptions, in most of cases with low specificity and no univocal temporal association with the onset of sys... |
Can India develop herd immunity against COVID-19? | World Health Organization declared the novel coronavirus disease 2019 (COVID-19) outbreak to be a public health crisis of international concern. Further, it provided advice to the global community that countries should place strong measures to detect disease early, isolate and treat cases, trace contacts and promote “s... |
Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration | |
An antibody derivative expressed from viral vectors passively immunizes pigs against transmissible gastroenteritis virus infection when supplied orally in crude plant extracts | To investigate the potential of antibody derivatives to provide passive protection against enteric infections when supplied orally in crude plant extracts, we have expressed a small immune protein (SIP) in plants using two different plant virus vectors based on potato virus X (PVX) and cowpea mosaic virus (CPMV). The ɛ... |
Addressing Challenges in Obtaining Emergency Medicine Away Rotations and Standardized Letters of Evaluation Due to COVID-19 Pandemic | |
Experimental inoculation of late term pregnant sows with a field isolate of porcine reproductive and respiratory syndrome vaccine-derived virus | Abstract The use of a live attenuated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in piglets has been associated with reproductive disorders in non-vaccinated sows. Vaccine-derived virus (VDV) has been isolated from foetuses, stillborn pigs, and dead piglets, indicating that the live vaccine spr... |
Synthesis and in vitro cytostatic activity of new β-d-arabino furan[1′,2′:4,5]oxazolo- and arabino-pyrimidinone derivatives | A series of nucleoside derivatives was obtained via heteroatom annulation of the amino oxazoline of d-(−)-arabinose. Unequivocal proofs for the stereostructure of some new arabinosyl pyrimidinone derivatives were obtained by X-ray structure analysis. These newly synthesized compounds were then evaluated for their cytos... |
Genetic Variation of SARS Coronavirus in Beijing Hospital | To characterize genetic variation of severe acute respiratory syndrome–associated coronavirus (SARS-CoV) transmitted in the Beijing area during the epidemic outbreak of 2003, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients on our unit, the Beijing 302 Hospital. Viral RNA templates for... |
Correlation between the variables collected at admission and progression to severe cases during hospitalization among patients with COVID‐19 in Chongqing | Mortality is high among severe patients with 2019 novel coronavirus‐infected disease (COVID‐19). Early prediction of progression to severe cases is needed. We retrospectively collected patients with COVID‐19 in two hospital of Chongqing from 1st January to 29th February 2020. At admission, we collected the demographics... |
Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes | Human Parainfluenza viruses (HPIV) type 1 and 3 are important causes of respiratory tract infections in young children globally. HPIV infections do not confer complete protective immunity so reinfections occur throughout life. Since no effective vaccine is available for the two virus subtypes, comprehensive understandi... |
Lesions pernióticas y acrales en España durante el confinamiento por COVID: análisis retrospectivo de 12 casos | |
Public Health Emergency Response in Taiwan | In recent years, growth of international travel and trade, as well as climate change, has resulted in the frequent emergence and reemergence of infectious diseases such as Ebola, Zika, and MERS. In 2016, Taiwan used the Joint External Evaluation (JEE) tool to evaluate its public health emergency response capacities and... |
An analysis of COVID-19 spread based on fractal interpolation and fractal dimension | The present paper proposes a reconstruction of the epidemic curves from the fractal interpolation point of view. Looking at the epidemic curves as fractal structures might be an efficient way to retrieve missing pieces of information due to insufficient testing and predict the evolution of the disease. A fractal approa... |
Social costs of tourism during the COVID-19 pandemic | The severe acute respiratory syndrome coronavirus 2 is currently spreading across the world at an alarming rate, resulting in the coronavirus disease 2019 pandemic. Amidst this crisis, tourism scholars are directing their attention to communities at tourist destinations, looking at their safety and well-being and the c... |
Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus | Abstract Many highly effective vaccines have been produced against viruses whose virulent infection elicits strong and durable protective immunity. In these cases, characterization of immune effector mechanisms and identification of protective epitopes/immunogens has been informative for the development of successful v... |
Anticoagulation Practice Patterns in COVID‐19: A Global Survey | BACKGROUND: Best practice for prevention, diagnosis, and management of venous thromboembolism (VTE) in patients with SARS‐CoV‐2 disease 2019 (COVID‐19) is unknown due to limited published data in this population. OBJECTIVES: We aimed to assess current global practice and experience in management of COVID‐19 associated ... |
Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age – a systematic review and meta-analysis | AIM: To estimate the proportional contribution of influenza viruses (IV), parainfluenza viruses (PIV), adenoviruses (AV), and coronaviruses (CV) to the burden of severe acute lower respiratory infections (ALRI). METHODS: The review of the literature followed PRISMA guidelines. We included studies of hospitalized childr... |
Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains | A large number of accidental virus infections occur in medical and non-medical workers exposed to infectious individuals and materials. We evaluated whether postmortem blood and bloodstains containing hepatitis B virus (HBV) are infectious. HBV-infected blood and bloodstains were stored for up to 60 days at room temper... |
New Virus, New Challenge | The ongoing COVID-19 pandemic has made us to consider the emergence of potential viral diseases in the future. Animals can carry vast and diverse virus species, most of which we do not understand yet, and the spillover events of the viruses from the unknown pool in animals to human population always occurred in the pas... |
Senior Medical Students in the COVID‐19 Response: An Opportunity to Be Proactive | On March 13th, the United States (US) declared the novel coronavirus (COVID-19) pandemic a national emergency. By March 18th , according to the Centers for Disease Control and Prevention, COVID-19 had spread to all 50 US states, with 7,038 cases and 97 deaths.1 The trajectory of cases mirrors that of Italy, where docto... |
Public Transport Operations After Lockdown: How to Make It Happen? | Lockdown in cities across the globe has imposed severe travel restrictions to limit the spread of Coronavirus disease. The travel behavior and operations will not be the same as before due to requirements such as physical (social) distancing. This study analyzes the resulting shortage in supply of public transport (bus... |
Trombosis y covid-19: atención primaria clave en el abordaje interdisciplinar | |
The psycho-social effects of COVID-19 on Italian adolescents’ attitudes and behaviors | BACKGROUND: COVID-19 is an emerging issue that has significant consequences on psycho-social well-being. METHODS: In this regard, a survey was conducted on a large group of adolescents in Italy. The survey investigated four items: concerns and fears, information on the pandemic, provisions of public authorities (e.g., ... |
Enhancement of SARS-CoV Infection by Proteases | |
The psychosocial effects of being quarantined following exposure to COVID-19: A qualitative study of Lebanese health care workers | BACKGROUND: Since the outbreak of the novel Coronavirus (COVID-19), health care professionals in Lebanon have been diligently serving as the frontline of defense. In the light of challenging economic and political circumstances, putting their community wellbeing as a priority, and abiding by quarantine and strict infec... |
Isolation, purification and immunobiological activity of a new water-soluble bee pollen polysaccharide from Crataegus pinnatifida Bge. | Abstract A novel water-soluble polysaccharide was obtained from bee pollen of Crataegus pinnatifida Bge. Two fractions of this polysaccharide, CPP-1 and CPP-2, were first extracted by hot-water and purified. The average molecular weight of CPP-1 and CPP-2 were approximately 3.7×105 Da and 7.8×104 Da, and their chemical... |
Convalescent plasma transfusion for the treatment of COVID‐19: Systematic review | The recent emergence of coronavirus disease 2019 (COVID‐19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID‐19 patients based on the publications reported till date. To our knowledge, this is the fi... |
Coronavirus Pandemic Hits Chinese Coatings Market | |
COVID-19 Suspection: A case report regarding a male emergency medical service pilot with newly diagnosed sarcoidosis | Abstract A 38-yr-old Emergency Medical Service Bell 214 male pilot with dry cough, fever, anorexia, fatigue and sweating for the past 3d, oral temperature 38°C, blood pressure 105/65 mm Hg, heart rate 94, respiratory rate 21, and pulse oximetry 93% on room air was suspicious for COVID-19. Surprisingly, RT-PCR was negat... |
Preparing for Pandemic Vaccination: An International Policy Agenda for Vaccine Development | The international use of influenza vaccine is growing, especially in developing countries. Since 1997, avian H5N1 influenza in Southeast Asia has caused several human infections and high mortality. Experts warn that the next influenza pandemic is imminent and could be severe. Prevention and control will depend on the r... |
Radiology Residency Program Management in the COVID Era – Strategy and Reality | |
Molar absorptivity and A(1cm)(1%) values for proteins at selected wavelengths of the ultraviolet and visible regions—XVIII | A table of molar absorptivity and A(1cm)(1%) values for more than 180 proteins is given. The conditions used to obtain these values and references to the original literature are also'given. |
The problems with contact-tracing apps | As countries look to ease restrictions and manage second waves of cases, apps are appealing but fraught with issues, reports Adam Vaughan |
Nasopharyngeal bacterial load as a marker for rapid and easy diagnosis of invasive pneumococcal disease in children from Mozambique | BACKGROUND: Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience. This study aimed to determine the performance of pneumococcal load quantified with a real-time polymerase-chain rea... |
Vaccines for the Elderly: The Quest for the Ideal Animal Model | Summary A decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and there is a ... |
A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients | BACKGROUND: Respiratory virus infections (RVIs) pose a threat to children undergoing hematopoietic stem cell transplantation (HSCT). In this era of sensitive molecular diagnostics, the incidence and outcome of HSCT recipients who are hospitalized with RVI (H-RVI) are not well described. METHODS: A retrospective observa... |
Rapid and efficient detection methods of pathogenic swine enteric coronaviruses | ABSTRACT: Porcine enteric coronaviruses (CoVs) cause highly contagious enteric diarrhea in suckling piglets. These COV infections are characterized by clinical signs of vomiting, watery diarrhea, dehydration, and high morbidity and mortality, resulting in significant economic losses and tremendous threats to the pig fa... |
Características, evolución clínica y factores asociados a la mortalidad en UCI de los pacientes críticos infectados por SARS-CoV-2 en España: estudio prospectivo, de cohorte y multi-céntrico | RESUMEN Antecedentes: No se ha reportado plenamente la evolución clínica de los pacientes críticos de COVID-19 durante su ingreso en la unidad de cuidados intensivos (UCI), incluyendo las complicaciones médicas e infecciosas y terapias de soporte, así como su asociación con la mortalidad en ICU. Objetivo: El objetivo d... |
Humanity tested | The world needs mass at-home serological testing for antibodies elicited by SARS-CoV-2, and rapid and frequent point-of-care testing for the presence of the virus’ RNA in selected populations. |
The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens | Abstract To examine the relationship of impairments of the liver and kidney with viral load after nephropathogenic infectious bronchitis virus (NIBV) infection in embryonic chickens, 120 specific-pathogen-free Leghorn embryonated chicken eggs were randomly divided into two groups (infected and control), with three repl... |
A review on HCV inhibitors: Significance of non-structural polyproteins | Hepatitis C virus (HCV) mortality and morbidity is a world health misery with an approximate 130–150 million chronically HCV tainted and suffering individuals and it initiate critical liver malfunction like cirrhosis, hepatocellular carcinoma or liver HCV cancer. HCV NS5B protein one of the best studied therapeutic tar... |
Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection | The spike glycoprotein of the Middle East respiratory coronavirus (MERS‐CoV) facilitates receptor binding and cell entry. During investigation of a multi‐facility outbreak of MERS‐CoV in Taif, Saudi Arabia, we identified a mixed population of wild‐type and variant sequences with a large 530 nucleotide deletion in the s... |
Assessment of samples pooling for SARS-CoV-2 molecular testing for screening of asymptomatic persons in Tunisia | Abstract The aim of this study is to test a pooling approach for the RT-PCR test to detect low viral loads of SARS-CoV-2. We found that a single positive specimen can still be detected in pools of up to 10. Each laboratory should conduct its own evaluation and validation of pooling protocols according to its specific c... |
An update on antiviral antibody-based biopharmaceuticals | Due to the vastness of the science virology, it is no longer an offshoot solely of the microbiology. Viruses have become as the causative agents of major epidemics throughout history. Many therapeutic strategies have been used for these microorganisms, and in this way the recognizing of potential targets of viruses is ... |
Confinée mais mobilisée, l’Académie nationale de médecine au temps de la Covid-19 | |
Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response | Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the pro-mitotic effect of physical activity. Here, we examine precursor cells in the adult brain of mice lacking angiotensin-converting enzyme (ACE) 2, and explore the e... |
Mobilization practices in critically ill children: a European point prevalence study (EU PARK-PICU) | BACKGROUND: Early mobilization of adults receiving intensive care improves health outcomes, yet little is known about mobilization practices in paediatric intensive care units (PICUs). We aimed to determine the prevalence of and factors associated with physical rehabilitation in PICUs across Europe. METHODS: A 2-day, c... |
Chapter 23 Lung, Pleura, and Mediastinum | Abstract The lung is constantly exposed to a large volume of inhaled air that may contain toxicant xenobiotics. With the possibility of exposure to a variety of respiratory toxicants from airborne pollutants in our environment during the course of daily activities, in occupational settings, the use of aerosol sprays fo... |
Decent Work, ILO’s Response to the Globalization of Working Life: Basic Concepts and Global Implementation with Special Reference to Occupational Health | Twenty years ago, the International Labour Organization (ILO) launched a new strategy, the Decent Work Agenda, to ensure human-oriented development in the globalization of working life and to provide an effective response to the challenges of globalization. We searched for and analysed the origin of the Decent Work con... |
Hybrid Coordination for Coping with the Medical Surge from the COVID‐19 Pandemic: Paired‐Assistance Programs in China | The COVID‐19 pandemic poses unprecedented challenges to public healthcare systems and demands intergovernmental coordination to cope with the resulting medical surge. This article analyzes the operation of Paired Assistance Programs (PAPs) in China, offering a timely comparative case for researchers and practitioners t... |
Clinical features of three avian influenza H7N9 virus‐infected patients in Shanghai | INTRODUCTION: Since February 2013, a novel reassortant H7N9 virus associated with human deaths, but no apparent outbreaks in poultry and wild birds has emerged in eastern China. OBJECTIVES: The potential reemergence of H7N9 during next year's influenza season demand a further understanding of this important disease. ME... |
Is susceptibility to severe COVID‐19 disease an inborn error of metabolism? | |
Severity of cardiovascular diseases during the COVID-19 pandemic: A letter in response to the article entitled “One train may hide another: Acute cardiovascular diseases could be neglected because of the COVID-19 pandemic.” by Huet et al | |
Non-autophagic roles of autophagy-related proteins | Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the u... |
2009 H1N1 influenza infection in Korean healthcare personnel | Healthcare personnel (HCP) can acquire influenza and transmit it to patients and other hospital staff. The aim of this study was to evaluate the attack rate of HCP by the 2009 H1N1 influenza virus during the 2009 pandemic influenza season in Korea. HCP infected with H1N1 virus were asked to fill out a questionnaire, wh... |
The impact of asymptomatic individuals on the strength of public health interventions to prevent the second outbreak of COVID-19 | The pandemic of coronavirus disease 2019 (COVID-19) has threatened the social and economic structure all around the world. Generally, COVID-19 has three possible transmission routes, including pre-symptomatic, symptomatic and asymptomatic transmission, among which the last one has brought a severe challenge for the con... |
Biomedical Research in Times of Emergency: Lessons From History | Coronavirus disease 2019 has disrupted the lives of billions of persons worldwide. Emergencies can stimulate substantial investment of resources that catalyze impressive scientific accomplishments but can also lead to false promises and ethical breaches. The authors discuss how history shows the importance of treating ... |
Comparative proteomic analysis reveals different responses in porcine lymph nodes to virulent and attenuated homologous African swine fever virus strains | African swine fever (ASF) is a pathology of pigs against which there is no treatment or vaccine. Understanding the equilibrium between innate and adaptive protective responses and immune pathology might contribute to the development of strategies against ASFV. Here we compare, using a proteomic approach, the course of ... |
Envelope glycoprotein interactions in coronavirus assembly | Coronaviruses are assembled by budding into smooth membranes of the intermediate ER-to-Golgi compartment. We have studied the association of the viral membrane glycoproteins M and S in the formation of the virion envelope. Using coimmunoprecipitation analysis we demonstrated that the M and S proteins of mouse hepatitis... |
Cloning, expression, and antiviral activity of interferon β from the Chinese microbat, Myotis davidii | Bats are natural reservoir hosts for many viruses that produce no clinical symptoms in bats. Therefore, bats may have evolved effective mechanisms to control viral replication. However, little information is available on bat immune responses to viral infection. Type I interferon (IFN) plays a key role in controlling vi... |
Chapter 4 Social Media and Health Crisis Communication During Epidemics | Abstract Reacting to public health threats as early as possible is crucial in preventing harm from large population groups. Surveillance systems support the management and early detection of disease activity. Besides traditional systems that rely on reported diagnoses from laboratories, electronic media and discussion ... |
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with disease severity in COVID-19 | A major unanswered question in the current global COVID-19 outbreak is why a small minority of infected individuals develop severe disease. Here we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age depend... |
Internal quality assurance in diagnostic microbiology: A simple approach for insightful data | Given the importance of microbiology results on patient care, high quality standards are expected. Internal quality assurance (IQA) could mitigate the limitations of internal quality control, competency assessment and external quality assurance, adding a longitudinal insight, including pre- and post-analytical steps. H... |
The nucleolus – a gateway to viral infection? | A number of viruses and viral proteins interact with a dynamic sub-nuclear structure called the nucleolus. The nucleolus is present during interphase in mammalian cells and is the site of ribosome biogenesis, and has been implicated in controlling regulatory processes such as the cell cycle. Viruses interact with the n... |
Bats in urban areas of Brazil: roosts, food resources and parasites in disturbed environments | Urbanization is a widespread intense land use that generally results in biodiversity decline. Among the taxa capable to adapt to urban landscapes, bats are particularly ubiquitous. Brazil has one of the world’s largest diversity of bat species and one of the highest urbanization rates of the world. Yet, few studies hav... |
4 General Systemic States | |
Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in Escherichia coli | BACKGROUND: Porcine epidemic diarrhea virus (PEDV) is a highly contagious enteric pathogen of swine. The spike glycoprotein (S) of PEDV is the major immunogenic determinant that plays a pivotal role in the induction of neutralizing antibodies against PEDV, which therefore is an ideal target for the development of subun... |
Cryptic transmission of SARS-CoV-2 in Washington State | Following its emergence in Wuhan, China, in late November or early December 2019, the SARS-CoV-2 virus has rapidly spread throughout the world. On March 11, 2020, the World Health Organization declared Coronavirus Disease 2019 (COVID-19) a pandemic. Genome sequencing of SARS-CoV-2 strains allows for the reconstruction ... |
Hepatic sinusoidal-obstruction syndrome and busulfan-induced lung injury in a post-autologous stem cell transplant recipient | Veno-occlusive disease of the liver is mostly encountered as a complication of hematopoietic stem cell transplantation with myeloablative regimens with an incidence estimated to be 13.7%. It is clinically characterized by tender hepatomegaly, jaundice, weight gain and ascites. Strong clinical suspicion and an early rec... |
A multi-faceted approach of a nursing led education in response to MERS-CoV infection | Abstract Background The emergence of the Middle East respiratory syndrome-coronavirus (MERS-CoV) resulted in multiple healthcare associated outbreaks. In response, we developed a nurse-led program to screen and triage patients with MERS-CoV infection. Methods A formal educational program was implemented to ensure a sta... |
Risk estimation of infectious diseases determines the effectiveness of the control strategy | Abstract Usually, whether to take vaccination or not is a voluntary decision, which is determined by many factors, from societal factors (such as religious belief and human rights) to individual preferences (including psychology and altruism). Facing the outbreaks of infectious diseases, different people often have dif... |
Antimalarial Activity of 4-Metoxychalcones: Docking Studies as Falcipain/Plasmepsin Inhibitors, ADMET and Lipophilic Efficiency Analysis to Identify a Putative Oral Lead Candidate | Herein, we report the antimalarial activity of nine 4-methoxychalcone derivatives 1a–i and an initial analysis of their ADMET properties. All compounds showed potent activity against the P. falciparum chloroquine-resistant clone W2, with IC(50) values ranging from 1.96 µM to 10.99 µM, with moderate or low cytotoxicity ... |
C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map | The group of pattern recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like receptors. They are key sensors for a number of infectious agents, some of which are oncogenic, and they launch an immune response against them, normally promoting their eradi... |
Why are vaccines against many human viral diseases still unavailable; an historic perspective? | The number of new and improved human viral vaccines licensed in recent years contrasts sharply with what could be termed the golden era (1955‐1990) when vaccines against polio‐, measles, mumps, rubella, and hepatitis B viruses first became available. Here, we attempt to explain why vaccines, mainly against viruses othe... |
Efficacy of slit lamp breath shields | PURPOSE: To evaluate the efficacy of slit lamp breath shields to prevent droplet spray from a simulated sneeze. DESIGN: Experimental study to test effectiveness of personal protective equipment. METHODS: The nozzle of a spray gun was adjusted to angularly disperse a mist of colored dye that approximated a patient sneez... |
Should we expect neurological symptoms in the SARS-CoV-2 epidemic? | Abstract Introduction There is growing evidence that SARS-CoV-2 can gain access to the central nervous system (CNS). We revise the literature on coronavirus infection of the CNS associated with neurological diseases. Development Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although... |
High incidence of rhinovirus infection in children with community‐acquired pneumonia from a city in the Brazilian pre‐Amazon region | Community‐acquired pneumonia (CAP) is the leading cause of child death worldwide. Viruses are the most common pathogens associated with CAP in children, but their incidence varies greatly. This study investigated the presence of respiratory syncytial virus (RSV), adenovirus, human rhinovirus (HRV), human metapneumoviru... |
Biochip sensors for the rapid and sensitive detection of viral disease | Recent advances in DNA and protein microarray methodology and the emerging technology of cell-based sensors have massively increased the speed and sensitivity with which we can detect viral infections. The advantages of the multi-parameter microarray technologies could be combined with the speed and sensitivity of cell... |
Recommandations de la SOFFCO-MM en vue de la reprise de l’activité de chirurgie bariatrique et métabolique pendant et après la pandémie covid-19 | Resumen Face à l’émergence de la pandémie à COVID 19, l’activité de chirurgie bariatrique/métabolique a été arrêtée. Le confinement et l’arrêt de cette chirurgie ont eu un impact sous-estimé sur la population obèse avec prise de poids, et aggravation des comorbidités. Un certain nombre de candidats à cette chirurgie so... |
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2 | BACKGROUND: The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2, also called 2019-nCoV) recently break out in Wuhan, China, and was named as COVID-19. With the spread of the disease, similar cases have also been confirmed in other regions of China. We aimed to report the imaging and clinical characteristics ... |
Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus | BACKGROUND: Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy... |
Starting a Biologic Therapy in IBD Patients Amid COVID-19: Hold, Careful Monitoring, or Testing? | |
Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory | Introduction. Middle East respiratory syndrome coronavirus was first recognized in September 2012 in Saudi Arabia. The clinical presentations of MERS and non-MERS SARI are often similar. Therefore, the identification of suspected cases that may have higher chances of being diagnosed as cases of MERS-CoV is essential. H... |
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