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Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS | In vivo two-photon imaging is a valuable technique for studies of viral pathogenesis and host responses to infection in vivo. In this protocol, we describe a methodology for analyzing influenza virus–infected lung in vivo by two-photon imaging microscopy. We describe the surgical procedure, how to stabilize the lung, a... |
CoronaVirus Disease 2019: Withdrawing Mechanical Ventilation to Reallocate Life Support Under Crisis Standards of Care—Nonequivalence of the Equivalence Thesis | |
The prospects for the SARS‐CoV‐2 pandemic in Africa | On December 31, 2019, the Chinese government officially announced the identification of a new type of coronavirus (SARS‐CoV‐2) as the etiological cause of a severe acute respiratory syndrome in Wuhan city, Hubei Province. Over the next weeks, SARS‐CoV‐2 caused a global pandemic as officially declared by the WHO on Marc... |
Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis | BACKGROUND: Multiple sclerosis (MS) is a disease of central nervous system that causes the removal of fatty myelin sheath from axons of the brain and spinal cord. Autoimmunity plays an important role in this pathology outcome and body's own immune system attacks on the myelin sheath causing the damage. The etiology of ... |
Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity | Abstract The prompt and tightly controlled induction of type I interferon is a central event of the immune response against viral infection. This response relies on the recognition of incoming pathogens by cellular pattern recognition receptors (PRRs), which then trigger various signaling cascades that result in proinf... |
COVID‐19 first stage in Japan – how we treat ‘Diamond Princess Cruise Ship’ with 3700 passengers? | |
Les zoonoses (tableaux synthétiques: animaux réservoirs de pathogènes et modes de transmission) | The knowledge of animals which act as reservoirs for human pathogenic agents is essential for the understanding of the epidemiology of zoonotic diseases and for the application of relevant methods of control. In the present article, synthetic tables present the main zoonoses due to viruses, bacteria, protozoa, helminth... |
Effects of feeding polyclonal antibody preparations on ruminal bacterial populations and ruminal pH of steers fed high-grain diets | Three experiments with factorial arrangements of treatments were designed to test the efficacy of avian-derived polyclonal antibody preparations (PAP) against Streptococcus bovis (PAP-Sb) or Fusobacterium necrophorum (PAP-Fn) in reducing ruminal counts of target bacteria in beef steers supplemented or not with feed add... |
Chapter 28 Lectin-like interactions in virus–cell recognition Human immunodeficiency virus and C-type lectin interactions | Publisher Summary The calcium-dependent lectin dendritic cell-specific ICAM-grabbing nonintegrin (DC-SIGN) is involved in human immunodeficiency virus (HIV) interactions with dendritic cells. Attachment of HIV to dendritic cells can potentiate viral infectivity for adjacent T-cells and it has been postulated that this ... |
Aspects spécifiques de la production dans le domaine des vaccins | Résumé La production de vaccin à l’échelle industrielle connaît son essor au cours de la seconde moitié du xx e siècle. Le vaccin est un médicament qui a la particularité de s’adresser à des sujets bien portants. Les principes actifs qui le composent sont issus d’organismes vivants et se différencient de ceux de la chi... |
Dairy calf rearing unit and infectious diseases: diarrhea outbreak by bovine coronavirus as a model for the dispersion of pathogenic microorganisms | Dairy calf rearing unit is a management system that is only recently being implemented by some milk producer’s cooperatives in southern Brazil. However, aspects related to the health profile of the heifer calves that arrive in the rearing unit as well as about biosecurity practices and microbiological challenges have n... |
Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an insight from a meta‐analysis | Elevation of high‐sensitivity cardiac troponin (hs‐cTn) is a surrogate of myocardial injury, which appears to be a common complication of coronavirus disease 2019 (COVID‐19). In this study, a meta‐analysis was performed to clarify the association between myocardial injury assessed by hs‐cTn levels and in‐hospital morta... |
The role of organisational interdependencies and asset orchestration in business integration: A case study of M.com | Business integration is an important determinant of business value and firm performance which enables a firm to respond to pressing competitive forces. Given its significant role, business integration in general has been an enduring research topic over the years. However, due to its complex nature, the ways to achieve ... |
Thromboprophylaxis for medical inpatients with COVID-19 | |
Le diagnostic virologique d'une infection respiratoire | Le diagnostic virologique d'une infection respiratoire exige théoriquement, comme celui de toute infection virale, la réunion de trois critères: o 1o l'isolement du virus, 2o une séroconversion vis-à-vis de ce virus, 3o des arguments épidémiologiques. Les deux premiers critères permettent d'affirmer l'association à l'i... |
Global hotspots and correlates of emerging zoonotic diseases | Zoonoses originating from wildlife represent a significant threat to global health, security and economic growth, and combatting their emergence is a public health priority. However, our understanding of the mechanisms underlying their emergence remains rudimentary. Here we update a global database of emerging infectio... |
Changes in Clinical Presentation and Epidemiology of Respiratory Pathogens Associated With Acute Respiratory Illness in Military Trainees After Reintroduction of Adenovirus Vaccine | Background. Adenovirus (Ad) has long been the predominant cause of acute respiratory illness (ARI) in military trainees. In 2011, live oral Ad vaccines for serotypes 4 and 7 were reintroduced into US basic military training populations. This study evaluated the impact on clinical presentations and other respiratory pat... |
Middle East Respiratory Syndrome Coronavirus Antibodies in Bactrian and Hybrid Camels from Dubai | So far, dromedary camels are the only known animal reservoir for Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV). Previous published serological studies showed that sera of Bactrian camels were all negative for MERS-CoV antibodies. However, a recent study revealed that direct inoculation of Bactrian came... |
Economic Assessment of Zoonotic Diseases: An Illustrative Study of Rift Valley Fever in the United States | This study evaluates the economic consequences of a Rift Valley Fever outbreak, a virus that spreads from livestock to humans, often through mosquitoes. Developing a ‘one health’ economic framework, economic impacts on agricultural producers and consumers, government costs of response, costs and disruptions to non‐agri... |
Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential | An overview on the diversity of 39 lectins from the phylum Porifera is presented, including 38 lectins, which were identified from the class of demosponges, and one lectin from the class of hexactinellida. Their purification from crude extracts was mainly performed by using affinity chromatography and gel filtration te... |
Procalcitonin levels and bacterial aetiology among COPD patients admitted to the ICU with severe pneumonia: a prospective cohort study | BACKGROUND: Serum procalcitonin (PCT) is considered useful in predicting the likeliness of developing bacterial infections in emergency setting. In this study, we describe PCT levels overtime and their relationship with bacterial infection in chronic obstructive pulmonary disease (COPD) critically ill patients with pne... |
Airborne Microorganisms From Livestock Production Systems and Their Relation to Dust | Large amounts of airborne microorganisms are emitted from livestock production. These emitted microorganisms may associate with dust, and are suspected to pose a risk of airborne infection to humans in vicinity and to animals on other farms. However, the extent to which airborne transmission may play a role in the epid... |
Effective Teaching and Examination Strategies for Undergraduate Learning During COVID-19 School Restrictions | On Friday, March 13, 2020, all school teaching in the Republic of Trinidad and Tobago, West Indies was suspended until further notice because of the novel coronavirus COVID-19 pandemic. This immediately jeopardized the completion of course content at the University of the West Indies, St. Augustine campus. This article... |
Exclusion of Pregnant Women from Clinical Trials during the Coronavirus Disease 2019 Pandemic: A Review of International Registries | Objective Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Study Design We conducted a search... |
A CRISPR toolbox to study virus–host interactions | Viruses depend on their hosts to complete their replication cycles; they exploit cellular receptors for entry and hijack cellular functions to replicate their genome, assemble progeny virions and spread. Recently, genome-scale CRISPR–Cas screens have been used to identify host factors that are required for virus replic... |
Traditional Chinese medicine played a crucial role in battling COVID-19 | |
Telemedicine Coding and Reimbursement - Current and Future Trends | Innovation in technology is redefining the world, including health care. Patients want convenient and quality interactions with their providers. The addition of telemedicine technologies and asynchronous provider-to-patient communications is creating a more connected model of health care that will improve access and th... |
Genotyping and phylogenetic analysis of canine parvovirus circulating in Egypt | AIM: This study aimed to detect and characterize current genotypes of canine parvovirus (CPV) in Egypt during 2018. MATERIALS AND METHODS: A total of 50 fecal swabs were collected from clinically infected domestic dogs of 2-5 months of age, suspected to suffer from CPV infection, from Cairo and Giza Governorates. The s... |
Resolution of obstructive sleep apnea after mandibular distraction osteogenesis in setting of delayed tongue–lip adhesion takedown: A case report | RATIONALE: There is a high prevalence of obstructive sleep apnea (OSA) in patients with Pierre Robin sequence (PRS), and treatment approaches are highly variable. One approach is a temporary tongue-lip adhesion (TLA) that acts as a temporizing measure while the mandible continues to grow and is usually taken down at 1 ... |
Comprehensive overview of COVID‐19 based on current evidence | In December 2019, twenty‐seven pneumonia patients with unknown causes originated in South China seafood market in Wuhan. The virus infection spread rapidly and swept through China in less than a month. Subsequently, the virus was proven a novel coronavirus and named SARS‐CoV‐2. The outbreak of novel coronavirus has bee... |
Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of Neonates | Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control c... |
Investigation of interunit dispersion in 2D street canyons: A scaled outdoor experiment | Abstract Interunit dispersion problems have been studied previously mainly through on-site measurements, wind tunnel tests, and CFD simulations. In this study, a scaled outdoor experiment was conducted to examine the interunit dispersion characteristics in consecutive two-dimensional street canyons. Tracer gas ( C O 2 ... |
Perforación intestinal en paciente covid-19 en tratamiento con tocilizumab y corticoides. A propósito de un caso | |
Novel IL-12 family members shed light on the orchestration of Th1 responses | Abstract Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess... |
Experimental measurements and large eddy simulation of expiratory droplet dispersion in a mechanically ventilated enclosure with thermal effects | Abstract Understanding of droplet transport in indoor environments with thermal effects is very important to comprehend the airborne pathogen infection through expiratory droplets. In this work, a well-resolved Large Eddy Simulation (LES) was performed to compute the concentration profiles of monodisperse aerosols in n... |
Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea) | Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad ... |
Airborne pathogen projection during ophthalmic examination | PURPOSE: Microscale droplets act as coronaviruses (CoV) carriers in the air when released from an infected person and may infect others during close contact such as ophthalmic examination. The main objective of the present work is to demonstrate how CoV deposited droplets are projected during biomicroscopy and to discu... |
Seroprevalence of porcine torovirus (PToV) in Spanish farms | BACKGROUND: Torovirus infections have been associated with gastroenteritis and diarrhea in horses, cows, pigs and humans, especially in young animals and in children. Although asymptomatic in a large percentage of cases, however toroviruses may pose a potential threat to worsen disease outcome in concurrent infections ... |
COVID -19 – Journal de Bord – Les étudiants en médecine et la pandémie | |
Emergency endoscopic variceal band ligation in a COVID‐19 patient presented with hematemesis while on mechanical ventilation | COVID‐19, caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2), is now a global pandemic with serious health consequences. Currently, many strict control measures are applied in health care settings, including endoscopy units, in order to limit virus spread. Several recommendations called to limit endos... |
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | BACKGROUND: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed. METHODS: We formed a pan... |
Chapter 71 Passive Immunization Toward Magic Bullets | Abstract Whereas active immunity refers to the process of exposing the individual to an antigen to generate an adaptive immune response, passive immunity refers to the transfer of antibodies from one individual to another. Passive immunity provides immediate but short-lived protection, lasting several weeks up to 3 or ... |
Global perspectives on primary immune deficiency diseases | Poverty, mass migration, live vaccines, inbred marriage, exotic dishes, contaminated water, natural disasters and the next pandemic, they may all affect your patient with a congenital immune defect. In this chapter, we discuss some interesting aspects and regional differences in the field of Primary immune deficiencies... |
Smooth or Risky Revisit of an Old Malaria Drug for COVID-19? | Hydroxychloroquine (HCQ) is an old medication for malaria. In addition to handling this parasitic disease, HCQ is also used to treat a number of autoimmune disorders including rheumatoid arthritis and systemic lupus erythematosus when other medications are not effective. Recently a new viral infection (COVID-19) is roc... |
Detecting Differential Transmissibilities That Affect the Size of Self-Limited Outbreaks | Our ability to respond appropriately to infectious diseases is enhanced by identifying differences in the potential for transmitting infection between individuals. Here, we identify epidemiological traits of self-limited infections (i.e. infections with an effective reproduction number satisfying [Image: see text]) tha... |
Management of septic shock and severe infections in migrants and returning travelers requiring critical care | During the past decade, global human movement created a virtually “borderless world”. Consequently, the developed world is facing “forgotten” and now imported infectious diseases. Many infections are observed upon travel and migration, and the clinical spectrum is diverse, ranging from asymptomatic infection to severe ... |
Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic | Abstract The coronavirus disease-2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 that has significant implications for the cardiovascular care of patients. First, those with COVID-19 and preexisting cardiovascular disease (CVD) have an increased risk of severe disease ... |
Making sense of mutation: what D614G means for the COVID-19 pandemic remains unclear | Abstract Korber et al. (2020) found that a SARS-CoV-2 variant in the spike protein, D614G, rapidly became dominant around the world. While clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely u... |
The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response | The interferon (IFN)-regulated endoribonuclease RNase-L is involved in multiple aspects of the antimicrobial innate immune response. It is the terminal component of an RNA cleavage pathway in which dsRNA induces the production of RNase-L-activating 2-5A by the 2′-5′-oligoadenylate synthetase. The active nuclease then c... |
Investigating public health emergency response information system initiatives in China | Abstract Infectious diseases pose a great danger to public health internationally. The outbreak of SARS has exposed China’s fragile public health system and its limited ability to detect and respond to emergencies in a timely and effective manner. In order to strengthen its capability of responding to future public hea... |
Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study | BACKGROUND: Spain is one of the European countries most affected by the COVID-19 pandemic. Serological surveys are a valuable tool to assess the extent of the epidemic, given the existence of asymptomatic cases and little access to diagnostic tests. This nationwide population-based study aims to estimate the seropreval... |
A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19) | The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global “pandemic”. At present, the efforts of various countries focus on the rapid dia... |
Primary structure of the glycoprotein E2 of coronavirus MHV-A59 and identification of the trypsin cleavage site | Abstract The nucleotide sequence of the peplomer (E2) gene of MHV-A59 was determined from a set of overlapping cDNA clones. The E2 gene encodes a protein of 1324 amino acids including a hydrophobic signal peptide. A second large hydrophobic domain is found near the COOH terminus and probably represents the membrane anc... |
Responsible Prescribing for Upper Respiratory Tract Infections | Upper respiratory tract infections (URTIs) are responsible for a large amount of community antibacterial use worldwide. Recent systematic reviews have demonstrated that most URTIs resolve naturally, even when bacteria are the cause. The high consumer expectation for antibacterials in URTIs requires intervention by the ... |
Choosing the Right Antibiotic in Ambulatory Care | Abstract The goal of this article is to be a quick guide for the nurse practitioner practicing in an ambulatory setting for making the right antibiotic choice for the right infection. With the use of a system-based approach, this article defines the most common infections seen in ambulatory care and their most common c... |
Estimating the burden of influenza‐associated hospitalization and deaths in Oman (2012‐2015) | BACKGROUND: Influenza is a serious vaccine‐preventable disease with high incidence, hospitalization, and mortality in high‐risk groups. The epidemiology, seasonality, and risk factors for influenza are well defined in most of the temperate countries, but estimating influenza burden in the World Health Organization (WHO... |
The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo | Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading enzyme, contains two forms and it can exert various physiological functions particular in controlling blood glucose through the action of GLP-1. In diabetic use, the DPP-4 inhibitor can block the DDP-4 to attenuate GLP-1 degradation ... |
Opportunities, Challenges and Directions in Science and Technology for Tackling COVID-19 | The ongoing global crisis due to Coronavirus disease-2019 (COVID-19) pandemic has caused an enormous socioeconomic burden. A novel coronavirus causing severe acute respiratory syndrome (SARS-CoV-2) that evolved from a virus infecting bats is responsible for COVID-19, first reported in the Chinese city of Wuhan. In the ... |
Occupational Health Response to SARS | |
Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus | |
Factors associated with increased all-cause mortality during the COVID-19 pandemic in Italy | Abstract Background The number of excess deaths in February-March 2020 in Italy, in comparison to the previous years, was considerably higher than recorded COVID19-related deaths. The present study is aimed at exploring the associations of excess mortality with some indices related to the epidemic and its management. M... |
TRAF3 signaling: Competitive binding and evolvability of adaptive viral molecular mimicry | Abstract Background: The tumor necrosis factor receptor (TNFR) associated factor 3 (TRAF3) is a key node in innate and adaptive immune signaling pathways. TRAF3 negatively regulates the activation of the canonical and non-canonical NF-κB pathways and is one of the key proteins in antiviral immunity. Scope of Review: He... |
Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death | BACKGROUND: WNV-associated encephalitis (WNVE) is characterized by increased production of pro-inflammatory mediators, glial cells activation and eventual loss of neurons. WNV infection of neurons is rapidly progressive and destructive whereas infection of non-neuronal brain cells is limited. However, the role of neuro... |
Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1 | Abstract Type I interferons (IFN-α/β) are the major components of the innate immune response of hosts, and in turn many viruses have evolved to modulate the host response during infection. We found that the IFN-β production was significantly suppressed during PEDV infection in cells. To identify viral IFN antagonists a... |
Analysis of codon usage patterns and influencing factors in Nipah virus | Abstract Codon usage bias (CUB) is the unequal usage of synonymous codons of an amino acid in which some codons are used more often than others and is widely used in understanding molecular biology, genetics, and functional regulation of gene expression. Nipah virus (NiV) is an emerging zoonotic paramyxovirus that caus... |
A Snapshot of SARS-CoV-2 Genome Availability up to April 2020 and its Implications: Data Analysis | BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been growing exponentially, affecting over 4 million people and causing enormous distress to economies and societies worldwide. A plethora of analyses based on viral sequences has already been published both in scientific journals... |
Cardiac Magnetic Resonance characterization of myocarditis-like acute cardiac syndrome in COVID-19 | |
Outbreak Trends of Coronavirus Disease–2019 in India: A Prediction | OBJECTIVE: The objective of this paper is to prepare the government and citizens of India to take or implement the control measures proactively to reduce the impact of coronavirus disease 2019 (COVID-19). METHOD: In this work, the COVID-19 outbreak in India has been predicted based on the pattern of China using a machi... |
Feline leucocyte antigen class II polymorphism and susceptibility to feline infectious peritonitis | Abstract There are four outcomes to feline coronavirus (FCoV) infection: the development of feline infectious peritonitis (FIP, which is immune-mediated), subclinical infection, development of healthy lifelong carriers and a small minority of cats who resist infection (Addie and Jarrett, Veterinary Record 148 (2001) 64... |
Post-translational modifications of coronavirus proteins: roles and function | Post-translational modifications (PTMs) refer to the covalent modifications of polypeptides after they are synthesized, adding temporal and spatial regulation to modulate protein functions. Being obligate intracellular parasites, viruses rely on the protein synthesis machinery of host cells to support replication, and ... |
Identification of functional, endogenous programmed −1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae | In viruses, programmed −1 ribosomal frameshifting (−1 PRF) signals direct the translation of alternative proteins from a single mRNA. Given that many basic regulatory mechanisms were first discovered in viral systems, the current study endeavored to: (i) identify −1 PRF signals in genomic databases, (ii) apply the prot... |
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity | COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity or as a therapeutic has yet been developed to SARS-CoV-2. In this study we discover and characterize a cross-reac... |
Dynamics of avian coronavirus circulation in commercial and non-commercial birds in Asia – a review | It is essential to understand the latest situation regarding avian coronaviruses (ACoVs), commonly referred to as the well-known avian infectious bronchitis virus (IBV), given that new and diverse types of IBV are continually being identified worldwide, particularly ones that are isolated from commercial poultry and as... |
H5N1 avian influenza in cats. ABCD guidelines on prevention and management | Overview Avian influenza is a disease of birds, caused by a type A influenza virus. The subtype H5N1 avian influenza occurs primarily in birds and infection varies from mild disease with little or no mortality to a highly fatal, rapidly spreading epidemic (highly pathogenic avian influenza). It is extremely rare for ca... |
Viral mimicry of the complement system | The complement system is a potent innate immune mechanism consisting of cascades of proteins which are designed to fight against and annul intrusion of all the foreign pathogens. Although viruses are smaller in size and have relatively simple structure, they are not immune to complement attack. Thus, activation of the ... |
Studying the global distribution of infectious diseases using GIS and RS | West Nile virus, severe acute respiratory syndrome and monkeypox are infectious diseases that have recently been introduced into areas far from their region of origin. The greatest risk of new diseases comes from zoonoses — pathogens that circulate among wild animals and are occasionally transferred to humans by interm... |
T-Cell Response to Viral Hemorrhagic Fevers | Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symp... |
COVID-19: Antikoagulation könnte Überlebenschancen erhöhen | |
Duck gut viral metagenome analysis captures snapshot of viral diversity | BACKGROUND: Ducks (Anas platyrhynchos) an economically important waterfowl for meat, eggs and feathers; is also a natural reservoir for influenza A viruses. The emergence of novel viruses is attributed to the status of co-existence of multiple types and subtypes of viruses in the reservoir hosts. For effective predicti... |
Hopefulness predicts resilience after hereditary colorectal cancer genetic testing: a prospective outcome trajectories study | BACKGROUND -: Genetic testing for hereditary colorectal cancer (HCRC) had significant psychological consequences for test recipients. This prospective longitudinal study investigated the factors that predict psychological resilience in adults undergoing genetic testing for HCRC. METHODS -: A longitudinal study was carr... |
“SARS-CoV-2: una presentación peculiar” | |
Covid 19. The paradox of social distancing. | Before 2020 the term ‘social distancing’ while not new, was barely known. The concept was promoted by the World Health Organisation in 2008 as a public health measure to prevent transmission of influenza, and in various forms it can be identified in reference to epidemics going back hundreds of years. However, in commo... |
Essais cliniques au cours de la pandémie COVID-19 : cibles thérapeutiques, exigences méthodologiques, impératifs éthiques | |
SARS-CoV-2: Camazotz's Curse | The world is currently face to face with a pandemic which is spreading rapidly across the globe caused by SARS-CoV-2, a strain of Coronaviruses (CoVs) belonging to subgenus Sarbecovirus of genus Betacoronavirus. World Health Organisation (WHO) on 11 Feb 20 named this disease caused by SARS-CoV-2 as Covid-19. This pande... |
Evaluation of Nucleocapsid and Spike Protein-Based Enzyme-Linked Immunosorbent Assays for Detecting Antibodies against SARS-CoV-2 | At present, PCR-based nucleic acid detection cannot meet the demands for coronavirus infectious disease (COVID-19) diagnosis. Two hundred fourteen confirmed COVID-19 patients who were hospitalized in the General Hospital of Central Theater Command of the People’s Liberation Army between 18 January and 26 February 2020 ... |
Alterations of growth hormone, cortisol, luteinizing hormone, and insulin concentrations in early-postnatal calves affected with diarrhea | Abstract The aim of the study was to investigate the influence of diarrheic infections during the early postnatal phase of calves on the concentrations of hormones controlling reproduction and metabolism. Blood samples were collected from 20 male and female calves via jugular vein catheters every 15 min for 6 hr at Day... |
Vaccine Rationing and the Urgency of Social Justice in the Covid‐19 Response | The Covid‐19 pandemic needs to be considered from two perspectives simultaneously. First, there are questions about which policies are most effective and fair in the here and now, as the pandemic unfolds. These polices concern, for example, who should receive priority in being tested, how to implement contact tracing, ... |
More bricks in the wall against SARS-CoV-2 infection: involvement of γ9δ2 T cells | |
COVID-19: ICU delirium management during SARS-CoV-2 pandemic—pharmacological considerations | |
Autophagy and the Immune Response | Innate immunity and adaptive immunity play critical roles in maintaining normal physiological functions and the development of diseases. In innate immune responses, heterogeneous autophagy can directly remove intracellular pathogens while activating PRRs, including TLRs and NLRs, to trigger their signal transduction pa... |
Structure of the equine arteritis virus nucleocapsid protein reveals a dimer–dimer arrangement | Equine arteritis virus (EAV) is an enveloped positive‐sense RNA virus belonging to the Arteriviridae family, which also includes the porcine pathogen PRRSV and is genetically and structurally related to the coronaviruses. EAV is an important equine pathogen that has caused significant economic losses to the horse‐breed... |
Coronavirus Disease 2019 (COVID‐19) in autoimmune hepatitis: a lesson from immunosuppressed patients | BACKGROUND & AIMS: Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Our aim was to describe the clinical course of immunosuppressed... |
Informed Consent for Emergency Obstetric Care During COVID-19 Pandemic | Informed consent process has become a challenging issue before surgery for any emergency obstetric care during this COVID pandemic. There is an increased risk of morbidity if there is a need of intensive care unit postoperatively and a risk of high mortality if patient has symptoms of COVID-19. Admission to intensive c... |
Feed batch sequencing to decrease the risk of porcine epidemic diarrhea virus (PEDV) cross-contamination during feed manufacturing | Feed has been identified as a vector of transmission for porcine epidemic diarrhea virus (PEDV). The objective of this study was to determine if feed batch sequencing methods could minimize PEDV cross-contamination. Porcine epidemic diarrhea virus-free swine feed was manufactured to represent the negative control. A 50... |
Clinical Issues—January 2012 | This Month Venous thromboembolism prophylaxis in pediatric patients Key words: pediatric patients, venous thromboembolism, prophylaxis. The Centers for Disease Control and Prevention surgical wound classification system Key words: surgical wound, wound classification, clean wound, clean-contaminated wound, contaminated... |
The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre- Golgi compartment | Evidence is accumulating that a distinct compartment(s) exists in the secretory pathway interposed between the rough ER (RER) and the Golgi stack. In this study we have defined a novel post-RER, pre-Golgi compartment where unassembled subunits of rubella virus (RV) E1 glycoprotein accumulate. When RV E1 is expressed in... |
New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176 | Small, cysteine-rich and cationic proteins with antimicrobial activity are produced by diverse organisms of all kingdoms and represent promising molecules for drug development. The ancestor of all industrial penicillin producing strains, the ascomycete Penicillium chryosgenum Q176, secretes the extensively studied anti... |
Potential for elimination of SAR‐CoV‐2 through vaccination as inspired by elimination of multiple influenza viruses through natural pandemics or mass vaccination | The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by the novel virus SARS‐CoV‐2 has claimed many lives worldwide. To combat the pandemic, multiple types of vaccines are under development with unprecedented rapidity. Theoretically, the future vaccination against COVID‐19 may fall into long‐term costly g... |
De novo transcriptome assembly and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in chlorogenic acid, luteolosides, and secoiridoid biosynthesis pathways | Lonicera japonica is one of the most important medicinal plants with applications in traditional Chinese and Japanese medicine for thousands of years. Extensive studies on the constituents of L. japonica extracts have revealed an accumulation of pharmaceutically active metabolite classes, such as chlorogenic acid, lute... |
Abordaje del duelo y de la muerte en familiares de pacientes con covid-19: revisión narrativa | Resumen Objetivo: Realizar una síntesis de la evidencia disponible para establecer recomendaciones sobre el abordaje del duelo y la muerte en familiares de pacientes Covid19 así como ofrecer recursos sustitutivos de los rituales y procedimientos necesarios con el fin de favorecer duelos funcionales y prevenir duelos co... |
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