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U.S. Medical Examiner/Coroner capability to handle highly infectious decedents | In the United States of America, Medical Examiners and Coroners (ME/Cs) investigate approximately 20% of all deaths. Unexpected deaths, such as those occurring due to a deceased person under investigation for a highly infectious disease, are likely to fall under ME/C jurisdiction, thereby placing the ME/C and other mor... |
Expression and purification of SARS coronavirus membrane protein | To construct a recombinant plasmid Pet23a-M, the gene encoding severe acute respiratory syndrome (SARS) coronavirus membrane protein was amplified by RT-PCR and cloned into the expression plasmid Pet23a. Results of restriction endonuclease analysis, PCR detection and DNA sequencing analysis revealed that the cloned DNA... |
Brexit and health security: why we need to protect our global networks | As the United Kingdom (UK) negotiates its separation from the European Union (EU), it is important to remember the public health mechanisms that are directly facilitated via our relationship with the EU. One such mechanism is the UK’s role within the European Centre for Disease Prevention and Control (ECDC). Global hea... |
Global threat of COVID 19 and evacuation of the citizens of different countries | Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected ... |
Neurosurgical management of brain and spine tumors in the COVID-19 era: an institutional experience from the epicenter of the pandemic | The challenges of neurosurgical patient management and surgical decision-making during the 2019–2020 COVID-19 worldwide pandemic are immense and never-before-seen in our generation of neurosurgeons. In this case-based formatted report, we present the Mount Sinai Hospital (New York, NY) Department of Neurosurgery instit... |
Epidemic and genetic characterization of porcine epidemic diarrhea virus strains circulating in the regions around Hunan, China, during 2017-2018 | Outbreaks of porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) infection have caused high mortality of piglets and significant economic losses to the Chinese swine industry. In the current study, 184 specimens from pigs with or without signs of diarrhea were collected from 39 farms across... |
Clinical evaluation of AusDiagnostics SARS-CoV-2 multiplex tandem PCR assay | BACKGROUND: In the context of the pandemic, the rapid emergency use authorisation of diagnostic assays for SARS-CoV-2 has meant there are few peer-reviewed published studies of clinical performance of commercial assays. AIMS: To evaluate the clinical performance of AusDiagnostics respiratory multiplex tandem PCR assay ... |
An Overview of Practical Applications of Protein Disorder Prediction and Drive for Faster, More Accurate Predictions | Protein disordered regions are segments of a protein chain that do not adopt a stable structure. Thus far, a variety of protein disorder prediction methods have been developed and have been widely used, not only in traditional bioinformatics domains, including protein structure prediction, protein structure determinati... |
Genomic and Proteomic Analysis of Schizaphis graminum Reveals Cyclophilin Proteins Are Involved in the Transmission of Cereal Yellow Dwarf Virus | Yellow dwarf viruses cause the most economically important virus diseases of cereal crops worldwide and are transmitted by aphid vectors. The identification of aphid genes and proteins mediating virus transmission is critical to develop agriculturally sustainable virus management practices and to understand viral strat... |
Preventing airborne infection | Good ventilation is essential in indoor spaces including planes |
Assessing the severity of COVID-19. | |
Epidemiology of infections following haploidentical peripheral blood hematopoietic cell transplantation | BACKGROUND: The use of T‐cell replete haploidentical hematopoietic cell transplant (haplo‐HCT) has increased substantially since the introduction of post‐transplant cyclophosphamide (PTCy) regimens. Limited data exist concerning infectious complications of haplo‐HCT utilizing mobilized peripheral blood (PB) hematopoiet... |
Role of sialic acids in rotavirus infection | Rotaviruses are the leading cause of childhood diarrhea. The entry of rotaviruses into the host cell is a complex process that includes several interactions of the outer layer proteins of the virus with different cell surface molecules. The fact that neuraminidase treatment of the cells, or preincubation of the virus w... |
Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection | In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the source of MERS-CoV zoonotic transmission and evidence of MERS-CoV circulation has b... |
Resolution of Acute Disseminated Encephalomyelitis Following Termination of Pregnancy | |
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1 | Venezuelan equine encephalitis virus (VEEV) is a previously weaponized arthropod-borne virus responsible for causing acute and fatal encephalitis in animal and human hosts. The increased circulation and spread in the Americas of VEEV and other encephalitic arboviruses, such as eastern equine encephalitis virus and West... |
Nutritional management of the foal with diarrhoea | Diarrhoea is a common problem in the neonatal and suckling foal. In certain circumstances supplemental nutrition is necessary depending on the age of foal, severity of diarrhoea and presence of other systemic manifestations. Nutritional supplementation can be provided either enterally or parenterally. Enteral nutrition... |
Human seroprevalence indicating hantavirus infections in tropical rainforests of Côte d’Ivoire and Democratic Republic of Congo | Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety of hemorrhagic fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, and bats since 2006. To i... |
Oral vitamin A supplementation of porcine epidemic diarrhea virus infected gilts enhances IgA and lactogenic immune protection of nursing piglets | Vitamin A (VA) has pleiotropic effects on the immune system and is critical for mucosal immune function and intestinal lymphocyte trafficking. We hypothesized that oral VA supplementation of porcine epidemic diarrhea virus (PEDV)-infected pregnant gilts would enhance the gut-mammary gland-secretory IgA axis to boost la... |
The practical need to challenge the status quo: New directions in bioethics | Abstract Those of us working in bioethics field take it for granted that the rest of the world reads our work and uses it as part of their scholarship and reasoning processes. Having widespread national and international influence is true for some of the biggest name bioethicists, but interactions at new international ... |
Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates | BACKGROUND: Although there is evidence of person-to-person transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in household and healthcare settings, more data are needed to describe and better understand the risk factors and transmission routes in both settings, as well as the extent to which diseas... |
Organisation de la ventilation artificielle dans les unités de réanimation en France | Résumé Objectifs Dans le domaine de la ventilation en réanimation, préciser le matériel, la formation des équipes, la maintenance et les référentiels disponibles. Type d’étude Enquête déclarative. Méthodes Entre septembre et décembre 2010, ont été recueillis : répartition et type des ventilateurs (ventilateurs lourds, ... |
Videogames and guns in adolescents: T ests of a bipartite theory | Abstract The possible role of video gaming in imprinting aggressive and specifically gun-related behaviors has been elusive, and findings regarding these associations have been inconsistent. I address this gap by proposing and testing a bipartite theory that can explain inconsistent results regarding the previously ass... |
Sepsis biomarkers: an omics perspective | Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. Th... |
Market report: Air Filters | Abstract Sales of air filters will rise at a rate of 8% per year over the next four years to US$6.2 billion in 2007, according to the continuously updated on-line report Air Filtration and Purification World Market, published by the McIlvaine Company. This is a short news story only. Visit www.filtsep.com for the lates... |
Emerging infectious diseases and biological invasions: a call for a One Health collaboration in science and management | The study and management of emerging infectious diseases (EIDs) and of biological invasions both address the ecology of human-associated biological phenomena in a rapidly changing world. However, the two fields work mostly in parallel rather than in concert. This review explores how the general phenomenon of an organis... |
Single Particle Tracking Assay to Study Coronavirus Membrane Fusion | Single particle tracking (SPT) of individual virion fusion with host cell membranes using total internal reflection microscopy (TIRFM) is a powerful technique for quantitatively characterizing virus–host interactions. One significant limitation of this assay to its wider use across many types of enveloped viruses, such... |
Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)? | Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic proportions. Caused by SARS-CoV-2, which stands for severe acute respiratory syndrome (SARS) coronavirus 2, the symptoms most commonly reported include cough, fever, and shortness of breath, but also extra-pulmonary symptoms, such as neur... |
Targeting the interleukin‐17 pathway to prevent acute respiratory distress syndrome associated with SARS‐CoV‐2 infection | |
Free market versus state or something else?: civic sector and competition law’s roles during the COVID-19 pandemic in Japan | COVID-19 is a highly transmittable disease. Until a vaccine is found, social distancing is the only way to prevent the virus from killing millions. Lockdown may also be necessary. Such measures inevitably cause an economic recession, so supplementing individuals’ incomes prove vital. Without income support, employees m... |
Evolutionary relationship analysis of Middle East respiratory syndrome coronavirus 4a and 4b protein coding sequences | The 4a and 4b proteins of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been described for their antagonism on host innate immunity. However, unlike clustering patterns of the complete gene sequences of human and camel MERS-CoVs, the 4a and 4b protein coding regions did not constitute species-specifi... |
First Isolation and Rapid Identification of Newcastle Disease Virus from Aborted Fetus of Dromedary Camel Using Next-Generation Sequencing | Newcastle disease virus (NDV) causes morbidities and mortalities in wild and domestic birds globally. For humans, exposure to infected birds can cause conjunctivitis and influenza-like symptoms. NDV infections in mammals are rarely reported. In this study, using next-generation sequencing, an NDV was identified and iso... |
Impact of Preexisting Adenovirus Vector Immunity on Immunogenicity and Protection Conferred with an Adenovirus-Based H5N1 Influenza Vaccine | The prevalence of preexisting immunity to adenoviruses in the majority of the human population might adversely impact the development of adaptive immune responses against adenovirus vector-based vaccines. To address this issue, we primed BALB/c mice either intranasally (i.n.) or intramuscularly (i.m.) with varying dose... |
Mechanistic Study of the Reaction of Thiol‐Containing Enzymes with α,β‐Unsaturated Carbonyl Substrates by Computation and Chemoassays | We investigated the reactions between substituted α,β‐unsaturated carbonyl compounds (Michael systems) and thiols by computations as well as chemoassays. The results give insight into variations in the underlying mechanisms as a function of the substitution pattern. This is of interest for the mechanisms of inhibition ... |
#pandemicpedagogy: using twitter for knowledge exchange | The COVID‐19 crisis has resulted in homeworking becoming the norm internationally. As a result, international, national and institutional medical education conferences, workshops and seminars have been cancelled or postponed indefinitely. Consequently, the opportunity for knowledge exchange and networking has been redu... |
Complete Genome Sequences of Four Bovine Coronavirus Isolates from Pennsylvania | We report four full-genome sequences of bovine coronavirus (BCoV) isolates from dairy calves in Pennsylvania obtained in 2016 and 2017. BCoV is a pathogen of great importance to cattle health, and this is the first report of full-genome sequences of BCoV from PA cattle. |
Analysis of the parameters of respiration patterns extracted from thermal image sequences | Abstract Remote estimation of vital signs is an important and active area of research. The goal of this work was to analyze the feasibility of estimating respiration parameters from video sequences of faces recorded using a mobile thermal camera. Different estimators were analyzed and experimentally verified. It was de... |
Axalta to Apply Antimicrobial Technology in Chicago Hospital for COVID-19 Patients | |
Are you prepared? Defining occupational health resource needs to prevent infectious disease transmission in the health care sector | Abstract This article discusses the extent of resource allocation to Occupational Health (OH) to prevent infectious disease exposure and transmission in British Columbia (B.C.). It also characterizes the delineation of roles and responsibilities within OH services in B.C. health care settings and highlights areas where... |
Body surface infrared thermometry in patients with central venous cateter-related infections | OBJECTIVE: To evaluate if body surface temperature close to the central venous catheter insertion area is different when patients develop catheter-related bloodstream infections. METHODS: Observational cross-sectional study. Using a non-contact infrared thermometer, 3 consecutive measurements of body surface temperatur... |
DEA, SAMHSA relax OTP/OBOT regulations due to COVID‐19 | Opioid treatment programs (OTPs) that dispense methadone got a fast and clear reprieve from federal authorities last week in the face of COVID‐19. The Drug Enforcement Administration (DEA) and the Substance Abuse and Mental Health Services Administration (SAMHSA) issued policies that give OTPs flexibility in take‐homes... |
Can we perform like SUPER-CRIPPLES during these crazy times of coronavirus pandemic? | |
Respiratory Viruses in Adults With Community-Acquired Pneumonia | Background Use of nucleic acid amplification techniques has increased the identification of respiratory viruses (RVs) in adult patients with community-acquired pneumonia (CAP). The objectives of the present study were to identify RV in patients with CAP using three different sampling methods and to compare CAP virus pr... |
What to expect from COVID-19 serology in a period of deconfinement? | |
Antibacterial activity of Artemisia asiatica essential oil against some common respiratory infection causing bacterial strains and its mechanism of action in Haemophilus influenzae | Abstract The main objective of the current study was to investigate the chemical composition of the essential oil of Artemisia asiatica together with investigating the antibacterial effects it exerts on several common respiratory infection causing bacteria including Haemophilus influenzae. Its mechanism of action was s... |
A New Decade of Veterinary Research: Societal Relevance, Global Collaboration, and Translational Medicine | |
Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19 | The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease 2019 (COVID-19), researchers from around the world are swiftly working on designing and identifying inhibitors against all possible viral key protei... |
Toward a conceptualization of supplier-switching processes in business relationships | Abstract This paper employs a practice perspective to study and conceptualize supplier-switching processes in business relationships. It is based on case study research of a company in the international marine industry, which intended to switch one of its key suppliers for a new one as a result of cost-cutting strategi... |
Unusually High Rates of Acute Rejection During the COVID-19 Pandemic: Cause for Concern? | |
Prospective Trial of Sacroiliac Joint Fusion Using 3D-Printed Triangular Titanium Implants | BACKGROUND: Prior trials provide strong evidence supporting minimally invasive sacroiliac joint (SIJ) fusion using triangular titanium implants (TTI) for chronic SIJ dysfunction. OBJECTIVE: To assess the safety and effectiveness of SIJF using a 3D-printed TTI. METHODS: Fifty-one subjects with carefully diagnosed SIJ dy... |
Safety management of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019 | Abstract This article introduces safety management strategies of nasopharyngeal specimen collection from suspected cases of coronavirus disease 2019 in a tertiary designated hospital. The key points includes establishing a special sampling room, strict sterilization of the entire environment, training of professional n... |
Laparoscopic Pneumoperitoneum Escape and Contamination during Surgery using the Airseal Insufflation System: Video Vignette | Unanticipated behaviours of the Airseal Insufflation and Access System (Conmed, NY, USA), in the public domain since 2017, have been recently restated by the manufacturer in light of the COVID19 pandemic and widespread concerns regarding aerosolization hazards during surgery. The associated video illustrates this devic... |
Foreword: Neonatal Intensive Care Unit Preparedness for the Novel Coronavirus Disease-2019 Pandemic: A New York City Hospital Perspective | |
Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic | |
Reality check for stem cell cures | Summary Four decades after the first preparation of embryonic stem cells, early hopes for regenerative medicine have failed to convert to real world applications. While rogue clinics try to cash in on unproven treatments, the real cures are still in medical trials and new avenues like the use of animals as intermediate... |
Public Response to Community Mitigation Measures for Pandemic Influenza | We report the results of a national survey conducted to help public health officials understand the public’s response to community mitigation interventions for a severe outbreak of pandemic influenza. Survey results suggest that if community mitigation measures are instituted, most respondents would comply with recomme... |
Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses | Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still represent a major medical need. Previously we developed a large variety of benzimidazole derivatives able to inhibit these viruses. Herein, two series of (thio)semicarbazone- and hydrazone-based benzimidazoles have been explore... |
Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen recognition and signal transduction | Pneumonia, a common disease caused by a great diversity of infectious agents is responsible for enormous morbidity and mortality worldwide. The bronchial and lung epithelium comprises a large surface between host and environment and is attacked as a primary target during lung infection. Besides acting as a mechanical b... |
Tetraspanin Assemblies in Virus Infection | Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins. If multiple microdomains associate with each other, larger platforms can f... |
Antibodies anti-Shiga toxin 2 B subunit from chicken egg yolk: Isolation, purification and neutralization efficacy | Abstract Shiga toxins (Stx1 and Stx2) are the main virulence factors of enterohemorrhagic Escherichia coli (EHEC), a foodborne pathogen associated with diarrhea, hemorrhagic colitis and hemolytic uremic syndrome. The aim of this study was to evaluate the antibodies against Stx2 obtained from egg yolks of laying hens im... |
Feline coronavirus-associated myocarditis in a domestic longhair cat | CASE SUMMARY: A 9-month-old entire male domestic longhair indoor cat presented with a 3-week history of fluctuating fever, weight loss and small intestine diarrhoea, which was unresponsive to antibiotics and supportive treatment. Abdominal ultrasound revealed severe jejunal and ileocolic junction intestinal wall thicke... |
Characteristics and Outcomes of COVID-19 Patients in New York City's Public Hospital System | Background New York City (NYC) has borne the greatest burden of COVID-19 in the United States, but information about characteristics and outcomes of racially/ethnically diverse individuals tested and hospitalized for COVID-19 remains limited. In this case series, we describe characteristics and outcomes of patients tes... |
Moderate to severe hidradenitis suppurativa under systemic therapy during the COVID‐19 outbreak | |
Death by food | Although death from food is not an uncommon finding in forensic facilities worldwide, the range of underlying lethal mechanisms and associated conditions that should be sought at the time of autopsy is quite disparate. Deaths may occur from i) infectious agents including bacteria, viruses, protozoa, cestodes, nematodes... |
Chapter 5 Viral Contamination of Food | Abstract A review of the relevant foodborne viruses is presented. Published data from scientific journals as well as the data presented in official reports and published on the Internet were used for this review. In the review, information is given for the main foodborne viruses, implicated virus species, and food matr... |
The effects of a prebiotic supplement (Prebio Support) on fecal and salivary IgA in neonatal dairy calves | Abstract The newborn calf's gastrointestinal tract is sterile at birth, but by 3days of age coliforms, Lactobacilli, and Bifidobacteria are the predominant flora in the feces. During the preweaning period, calves are susceptible to diarrhea that can lead to high levels of morbidity and mortality. Diarrhea has been rela... |
2019 novel coronavirus disease (COVID-19) in hemodialysis patients: a report of two cases | Abstract Objective To analyze the diagnosis and treatment of patients with chronic renal failure complicated with novel coronavirus pneumonia, and to evaluate the effect of blood purification technology on the treatment and prognosis of such patients Methods Two COVID-19 cases undergoing hemodialysis with chronic renal... |
Recommendations for the organization of electrophysiology and cardiac pacing services during the COVID-19 pandemic: Latin American Heart Rhythm Society (LAHRS) in collaboration with: Colombian College Of Electrophysiology, Argentinian Society of Cardiac Electrophysiology (SADEC), Brazilian Society Of Cardiac Arrhythmia... | COVID-19 is a rapidly evolving public health emergency that has largely impacted the provision of healthcare services around the world. The challenge for electrophysiology teams is double; on one side preventing disease spread by limiting all nonessential face-to-face interactions, but at the same time ensuring continu... |
Advances in antiviral nucleoside analogues and their prodrugs | |
Short-term outcome of critically ill patients with severe acute respiratory syndrome | OBJECTIVE: To document the outcome and determine prognostic factors for patients with severe acute respiratory syndrome who require admission to an intensive care unit. DESIGN: Observational cohort study involving retrospective analysis of demographic, clinical, laboratory and radiological data. SETTING: Adult intensiv... |
COVID‐19 rise in Younger adults with Obesity: Visceral Adiposity can predict the Risk | A concerning rise in coronavirus disease 2019 (COVID‐19) cases has been recently reported, particularly in the USA. The causes of this increase are likely multifactorial and the object of an ongoing health and socio‐economic debate. However, preliminary data indicate that the new COVID‐19 cases are increasing among you... |
Mechanisms of rhinovirus-induced asthma | Abstract Several epidemiological studies using sensitive detection methodologies have confirmed that the majority of acute asthma exacerbations follow upper respiratory tract infections – common colds. Most of these colds are due to human rhinoviruses (RVs). RVs are able to reach and replicate in epithelial cells of th... |
Emerging Infectious Diseases in Free-Ranging Wildlife–Australian Zoo Based Wildlife Hospitals Contribute to National Surveillance | Emerging infectious diseases are increasingly originating from wildlife. Many of these diseases have significant impacts on human health, domestic animal health, and biodiversity. Surveillance is the key to early detection of emerging diseases. A zoo based wildlife disease surveillance program developed in Australia in... |
Tracing environmental markers of autoimmunity: introducing the infectome | We recently introduced the concept of the infectome as a means of studying all infectious factors which contribute to the development of autoimmune disease. It forms the infectious part of the exposome, which collates all environmental factors contributing to the development of disease and studies the sum total of burd... |
The use of masks and respirators to prevent transmission of influenza: a systematic review of the scientific evidence | Please cite this paper as: bin‐Reza et al. (2012) The use of masks and respirators to prevent transmission of influenza: a systematic review of the scientific evidence. Influenza and Other Respiratory Viruses 6(4), 257–267. There are limited data on the use of masks and respirators to reduce transmission of influenza. ... |
DIC in COVID‐19: Implications for Prognosis and Treatment? | The ongoing COVID‐19 pandemic is an exceptional challenge for the health systems throughout the world. So far, no causative therapy nor protective vaccines are available. In several countries, the capacities for intensive care and for support in case of acute respiratory distress syndrome (ARDS) are overstretched, and ... |
Chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19): A single-center case study in Ningbo, China | OBJECTIVE: The purpose of this study was to investigate the chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19) in Ningbo, China. METHODS: In this retrospective study, twenty-eight confirmed and seven highly suspected cases of COVID-19 were enrolled in Ningbo first hospital from Januar... |
Carbohydrate arrays as tools for the glycomics revolution | Abstract Determining the roles of carbohydrates in cell biology is hindered by the tremendous efforts that must be taken either to synthesize carbohydrates chemically or to isolate them from natural sources. Several platforms have been developed to study glycobiology. These platforms include the covalent and non-covale... |
World Health Organization Methodology to Prioritize Emerging Infectious Diseases in Need of Research and Development | The World Health Organization R&D Blueprint aims to accelerate the availability of medical technologies during epidemics by focusing on a list of prioritized emerging diseases for which medical countermeasures are insufficient or nonexistent. The prioritization process has 3 components: a Delphi process to narrow down ... |
Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus(,)(2) | Mannan-containing products are capable of modulating immune responses in animals. However, different products may have diverse immunomodulation. The experiment was conducted to examine effects of mannan oligosaccharide (Actigen; ACT) on growth performance and serum concentrations of antibodies and inflammatory mediator... |
Systems biology approach: Panacea for unravelling host-virus interactions and dynamics of vaccine induced immune response | Abstract Systems biology is an interdisciplinary research field in life sciences, which involves a comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. For the past 50years the discipline of virology has overly focused on the pathogen itself. However... |
Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? | PURPOSE OF REVIEW: The highly infectious transmissible disease, the novel SARS-CoV-2, causing the coronavirus disease (COVID-19), has a median incubation time of 5 to 15 days. The symptoms vary from person to person and many are “hidden carriers.” Few people experience immediate reaction and even death within 48 h of i... |
Discovery of a divergent HPIV4 from respiratory secretions using second and third generation metagenomic sequencing | Molecular detection of viruses has been aided by high-throughput sequencing, permitting the genomic characterization of emerging strains. In this study, we comprehensively screened 500 respiratory secretions from children with upper and/or lower respiratory tract infections for viral pathogens. The viruses detected are... |
Chapter 53 Eye | Abstract The Eye chapter of the 3rd edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology brings a comprehensive description of pathological processes affecting the ocular tissues in the most commonly used laboratory animals and their correlations with human diseases of interest in toxicology. Also prese... |
Persistent viral RNA positivity during recovery period of a patient with SARS‐CoV‐2 infection | As an emerging infectious disease, the clinical course and virological course of SARS‐CoV‐2 infection remain to be further investigated. In this case report, we described a case of SARS‐CoV‐2 infection with clinical course more than two months. This patient had recovered from the pneumonia after treatment. The viral RN... |
Intracranial Hemorrhage in COVID-19 Patients on ECMO: Challenges and Future Directions | |
Biospecimen Repositories and Integrated Databases as Critical Infrastructure for Pathogen Discovery and Pathobiology Research | |
Papular cutaneous lesions in a cat associated with feline infectious peritonitis | A 7‐month‐old‐intact male domestic shorthair cat was presented with fever, anterior uveitis in the right eye and respiratory distress when handled. These signs along with mild changes in serum protein levels and the exclusion of other potential causes were suggestive of feline infectious peritonitis (FIP). As the disea... |
One Health stakeholder and institutional analysis in Kenya | INTRODUCTION: One Health (OH) can be considered a complex emerging policy to resolve health issues at the animal–human and environmental interface. It is expected to drive system changes in terms of new formal and informal institutional and organisational arrangements. This study, using Rift Valley fever (RVF) as a zoo... |
Pathological consequences of the unfolded protein response and downstream protein disulphide isomerases in pulmonary viral infection and disease | Protein folding within the endoplasmic reticulum (ER) exists in a delicate balance; perturbations of this balance can overload the folding capacity of the ER and disruptions of ER homoeostasis is implicated in numerous diseases. The unfolded protein response (UPR), a complex adaptive stress response, attempts to restor... |
Single‐cell RNA analysis on ACE2 expression provides insights into SARS‐CoV‐2 potential entry into the bloodstream and heart injury | Coronavirus disease‐2019 (COVID‐19) is a global pandemic with high infectivity and pathogenicity, accounting for tens of thousands of deaths worldwide. Recent studies have found that the pathogen of COVID‐19, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), shares the same cell receptor angiotensin convert... |
Recomendaciones sobre el manejo de pacientes adultos con enfermedades reumáticas en el contexto de la infección por SARS-CoV-2 / COVID-19. Asociación Colombiana de Reumatología | Resumen Objetivo: generar las recomendaciones para la atención de pacientes con enfermedades reumáticas que reciben terapias inmunomoduladoras e inmunosupresoras (fármacos convencionales, biológicos y moléculas pequeñas) durante la pandemia por COVID-19. Materiales y métodos: las recomendaciones se realizaron utilizand... |
COVID-19-Related Information Sources and Psychological Well-being: An Online Survey Study in Taiwan | • For the public, receiving information sources from medical staff and the Internet was associated with better and poorer psychological well-being, respectively. • For health care workers, attending formal lessons was significantly associated with better psychological well-being in coping with COVID-19. • People used a... |
Acute Respiratory Infections in a Recently Arrived Traveler to Your Part of the World* | Many acute infectious pulmonary diseases have incubation periods that are long enough for travelers to have symptoms after returning home to a health-care system that is not familiar with “foreign” infections. Respiratory infections have a relatively limited repertoire of clinical manifestations, so that there is often... |
Effects of awareness diffusion and self-initiated awareness behavior on epidemic spreading - An approach based on multiplex networks | Abstract In this paper, we study the interplay between the epidemic spreading and the diffusion of awareness in multiplex networks. In the model, an infectious disease can spread in one network representing the paths of epidemic spreading (contact network), leading to the diffusion of awareness in the other network (in... |
Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold | Purpose: To present a critical evaluation of the current evidence concerning the therapeutic value of vitamin C for the prophylaxis and treatment of the common cold. Data sources: Cochrane, PubMed, Natural Standard, and the National Center for Complementary and Alternative Medicine databases were searched to identify a... |
Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays | Serological SARS-CoV-2 assays are urgently needed for diagnosis, contact tracing and for epidemiological studies. So far, there is limited data on how recently commercially available, high-throughput immunoassays, using different recombinant SARS-CoV-2 antigens, perform with clinical samples. Focusing on IgG and total ... |
Absolute and Relative Quantification of Multiplex DNA Assays Based on an Elemental Labeling Strategy | Elements and quantification: A nucleic acid assay has been developed, based on an elemental labeling strategy using magnetic microparticles (MMPs), which provides quantification of multiple DNA targets. Rare‐earth elements, indium, and stable isotopes could be labeled with oligonucleotides serving as DNA probes. Quanti... |
Modelling insights into the COVID-19 pandemic | Coronavirus disease 2019 (COVID-19) is a newly emerged infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was declared a pandemic by the World Health Organization on 11th March, 2020. Response to this pandemic has required extensive collaboration across the scientific com... |
Filovirus Entry | A number of advances in recent years have significantly furthered our understanding of filovirus attachment and cellular tropism. For example, several cell-surface molecules have been identified as attachment factors with the potential to facilitate the in vivo targeting of particular cell types such as macrophages and... |
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