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(+)-Catechin inhibition of transmissible gastroenteritis coronavirus in swine testicular cells is involved its antioxidation | ABSTRACT Transmissible gastroenteritis virus (TGEV) causes transmissible gastroenteritis (TGE), especially in newborn piglets, which severely threatens the worldwide pig industry. In this study, (+)-catechin was evaluated for its antiviral effect against TGEV in vitro. Viability assays revealed that (+)-catechin treatm... |
Can routine laboratory tests discriminate SARS‐CoV‐2‐infected pneumonia from other causes of community‐acquired pneumonia? | BACKGROUND: The clinical presentation of SARS‐CoV‐2‐infected pneumonia (COVID‐19) resembles that of other etiologies of community‐acquired pneumonia (CAP). We aimed to identify clinical laboratory features to distinguish COVID‐19 from CAP. METHODS: We compared the hematological and biochemical features of 84 patients w... |
A 55‐year‐old COVID‐19‐positive man managed with self‐regulation of high‐flow oxygen by high‐velocity nasal insufflation therapy | Management of critically ill coronavirus disease 2019 (COVID‐19) patients remains both risky and technically challenging. A 55‐year‐old male COVID‐19‐positive patient with obstructive sleep apnoea (OSA), diabetes, and obesity presented with cough and shortness of breath, escalating to requiring high‐flow oxygen therapy... |
Artrópodos vectores en España y sus enfermedades transmisibles | Resumen Diferentes aspectos relacionados con la globalización junto a la gran capacidad de los artrópodos vectores para adaptarse a un mundo cambiante propician la emergencia y reemergencia de numerosos procesos infecciosos transmitidos por los mismos. Dípteros (culícidos y flebótomos), garrapatas, pulgas y piojos, ent... |
Response letter to COIVD-19 Disease: Tackling a pandemic in 21(st) Century | |
Hospital wastewater treatment scenario around the globe | Wastewaters generated from hospitals contain pharmaceuticals residues, pathogens, chemical reagents, radionuclide, and other harmful matter. The wastewater characteristics, quantity, and handling methods have not only variations among countries but also within a country. Some hazardous substances of hospital wastewater... |
Zoonotic Disease Programs for Enhancing Global Health Security | Most infectious diseases that recently emerged in humans originated in animals. Besides close contact between animals and humans, other factors probably contribute to the cross-species transmission of infectious diseases. It is critical to establish effective mechanisms for coordination and collaboration between the an... |
Avascular osteonecrosis after treatment of SARS: a 3‐year longitudinal study | Objective To investigate the relationship between avascular osteonecrosis (AVN) and corticosteroid treatment given to patients with severe acute respiratory syndrome (SARS). Methods Longitudinal study of 71 former SARS patients (mainly health care workers) who had been treated with corticosteroids, with an observation ... |
Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung | The swine-origin pandemic (p) H1N1 influenza A virus causes mild upper-respiratory tract disease in most human patients. However, some patients developed severe lower-respiratory tract infections with fatal consequences, and the cause of these infections remain unknown. Recently, it has been suggested that different po... |
Overview of Infectious Disease Surveillance System in Japan, 1999-2005 | BACKGROUND: In 1999 the Communicable Disease Prevention Law of Japan was completely revised into the "New" Infectious Disease Control Law, which reiterated the importance of surveillance and information dissemination and re-organized the surveillance system. This paper is an attempt to illustrate the potential impact o... |
Proteomic analyser with applications to diagnostics and vaccines | Abstract This paper describes a method for proteomic analysis with applications to diagnostics and vaccines. A panel of N (⪢1) reagents called X(j), with j=1 to N, is used. The binding strength of each of the X(j) reagents to each other is measured, for example by an ELISA assay, giving an N×N matrix K . The matrix K i... |
Bovine adenovirus-3 as a vaccine delivery vehicle | Abstract The use of vaccines is an effective and relatively inexpensive means of controlling infectious diseases, which cause heavy economic losses to the livestock industry through animal loss, decreased productivity, treatment expenses and decreased carcass quality. However, some vaccines produced by conventional mea... |
Gene regulation: translational initiation by internal ribosome binding | Abstract During the past year, several examples of cellular mRNAs have been described in which translational initiation occurs by internal ribosome binding, a mechanism hitherto thought to be restricted to picornaviral RNAs. New insights into the molecular mechanism of internal ribosome entry have been provided by the ... |
Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response | Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED). PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine industry. Interferons (IFN... |
Chapter 3 Measuring, Monitoring, and Evaluating the Health of a Population | Abstract Public health depends on information derived from monitoring population health status to identify community health problems, and to diagnose and investigate health problems and hazards in the community. These depend on vital statistics and disease reporting systems, including for non-communicable diseases, inj... |
Ventilating multiple patients on a single ventilator: Statement from the French Society of Anaesthesia and Intensive Care Medicine (SFAR) | |
Complete Genome Characterization of Korean Porcine Deltacoronavirus Strain KOR/KNU14-04/2014 | In April 2014, porcine deltacoronavirus (PDCoV) was first identified in feces from diarrheic piglets in South Korea and found to be closely related to other PDCoV strains. The complete genome of the Korean PDCoV strain, KOR/KNU14-04/2014, was sequenced and analyzed to characterize PDCoV circulating in South Korea. |
Recent patent applications in antiviral vaccines | |
Competitive Fitness in Coronaviruses Is Not Correlated with Size or Number of Double-Membrane Vesicles under Reduced-Temperature Growth Conditions | Positive-stranded viruses synthesize their RNA in membrane-bound organelles, but it is not clear how this benefits the virus or the host. For coronaviruses, these organelles take the form of double-membrane vesicles (DMVs) interconnected by a convoluted membrane network. We used electron microscopy to identify murine c... |
Dangerous state of denial | Despite the warning shots of SARS and last year's Asian outbreak of avian flu, governments are still not doing enough to monitor and prepare for the next viral pandemic. This inaction is scandalous. |
Viral Genomics and Bioinformatics | |
Detection of Coronaviruses in Bats of Various Species in Italy | Bats are natural reservoirs for many mammalian coronaviruses, which have received renewed interest after the discovery of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) CoV in humans. This study describes the identification and molecular characterization of alphacoronavirus... |
The Impact of COVID-19 related Measures on the Solar Resource in Areas with High Levels of Air Pollution | Abstract: Restrictions enacted to reduce the spreading of COVID-19 have resulted in notably clearer skies around the world. In this study, we confirm that reduced levels of air pollution correlate with unusually high levels of clear sky insolation in Delhi, India. Restrictions here were announced on March 19th, with th... |
Ocular abnormalities associated with hypovitaminosis A in Hanwoo calves: a report of two cases | This study reports on two Hanwoo (a native Korean breed of cattle) calves, a 3- and 6-month-old presenting with diarrhea, anorexia and blindness. Ophthalmoscopic examination revealed bilateral papilledema in both calves. Reverse-transcription polymerase chain reaction tests for bovine viral diarrhea virus, rotavirus an... |
Molecular Pathogenesis of Secondary Bacterial Infection Associated to Viral Infections Including SARS-CoV-2 | Secondary bacterial infections are commonly associated with prior or concomitant respiratory viral infections. Viral infections damage respiratory airways and simultaneously defects both innate and acquired immune response that provides a favorable environment for bacterial growth, adherence, and facilitates invasion i... |
Genomic and antigenic characterization of bovine parainfluenza-3 viruses in the United States including modified live virus vaccine (MLV) strains and field strains from cattle | Abstract This study investigated the genetic and antigenic characterization of parainfluenza-3 virus (PI3V) of cattle. Using molecular tests including real time PCR and viral genome sequencing, PI3V strains could be separated into PI3V types, including PI3V A, PI3V B, and PI3V C. Isolates from cattle with bovine respir... |
WHO led the digital transformation of your company? A reflection of IT related challenges during the pandemic | In this paper we reflect on a number of IT related challenges during the COVID19 pandemic, primarily from a CIO and IT professionals perspective. We consider three time periods, namely the period before the pandemic, the response to the pandemic and the period after it. For each period we discuss the key challenges tha... |
A Methodology for Determining Which Diseases Warrant Care in a High-Level Containment Care Unit † | Although the concept of high-level containment care (HLCC or ‘biocontainment’), dates back to 1969, the 2014–2016 outbreak of Ebola virus disease (EVD) brought with it a renewed emphasis on the use of specialized HLCC units in the care of patients with EVD. Employment of these units in the United States and Western Eur... |
High Viral Load of Human Bocavirus Correlates with Duration of Wheezing in Children with Severe Lower Respiratory Tract Infection | BACKGROUND: Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study is to assess the impact of HBoV viral load on clinical characteristics in children who were HBoV p... |
Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections | Viruses are the major cause of pediatric acute respiratory tract infection (ARTI) and yet many suspected cases of infection remain uncharacterized. We employed 17 PCR assays and retrospectively screened 315 specimens selected by season from a predominantly pediatric hospital‐based population. Before the Brisbane respir... |
Rheum australe, an endangered high-value medicinal herb of North Western Himalayas: a review of its botany, ethnomedical uses, phytochemistry and pharmacology | Rheum australe (Himalayan Rhubarb) is a multipurpose, endemic and endangered medicinal herb of North Western Himalayas. It finds extensive use as a medicinal herb since antiquity in different traditional systems of medicine to cure a wide range of ailments related to the circulatory, digestive, endocrine, respiratory a... |
Anaesthetic Considerations for Rationalizing Drug Use in the Operating Theatre: Strategies in a Singapore Hospital During COVID-19 | COVID-19 patients in the critical care unit tend to have prolonged hospital stay requiring high doses of sedation and paralysis to treat acute respiratory distress syndrome, resulting in a shortage of these drugs. In our hospital, we have instituted strategies to rationalise drug and oxygen usage. This includes priorit... |
On the Treatment of Airline Travelers in Mathematical Models | The global spread of infectious diseases is facilitated by the ability of infected humans to travel thousands of miles in short time spans, rapidly transporting pathogens to distant locations. Mathematical models of the actual and potential spread of specific pathogens can assist public health planning in the case of s... |
Why Italian ENT physicians should be aware of SARS-CoV-2 | Perchè gli specialisti ORL italiani devono stare in guardia contro SARS-CoV-2. |
ELISA for human serum leucine-rich alpha-2-glycoprotein-1 employing cytochrome c as the capturing ligand | Abstract Leucine-rich alpha-2-glycoprotein-1 (LRG) is a serum glycoprotein of unknown function that has shown promise based on qualitative assessments as a biomarker for certain diseases including microbial infections and cancer. However, the lack of a quantitative assay for LRG has limited its application. Here an ind... |
Carbohydrate Antigen Microarrays | This chapter describes one of my laboratory’s working protocols for carbohydrate-based microarrays. Using a standard microarray spotter, we print carbohydrate antigens directly on the nitrocellulose-coated bioarray substrates. Because these substrates support noncovalent immobilization of many spotted antigens, in gene... |
Prevalence and risk factors of feline leukaemia virus and feline immunodeficiency virus in peninsular Malaysia | BACKGROUND: Feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) are major causes of morbidity and mortality in domestic and wild felids. Despite the clinical importance of feline retroviruses and the growing interest in cats as pets, information about FeLV and FIV in Malaysia is presently insufficient... |
Nucleic acid-based diagnostics for infectious diseases in public health affairs | Infectious diseases, mostly caused by bacteria and viruses but also a result of fungal and parasitic infection, have been one of the most important public health concerns throughout human history. The first step in combating these pathogens is to get a timely and accurate diagnosis at an affordable cost. Many kinds of ... |
The effect of Severe Acute Respiratory Syndrome on a hospital obstetrics and gynaecology service | |
Numerical investigation of airborne contaminant transport under different vortex structures in the aircraft cabin | Abstract Airborne contaminants such as pathogens, odors and CO2 released from an individual passenger could spread via air flow in an aircraft cabin and make other passengers unhealthy and uncomfortable. In this study, we introduced the airflow vortex structure to analyze how airflow patterns affected contaminant trans... |
The murine coronavirus as a model of trafficking and assembly of viral proteins in neural tissue | Abstract The replication of JHM, a murine coronavirus, provides a useful model of the assembly and dissemination of viral components in neuronal cells. Involvement of microtubules in virus trafficking is an important feature which may explain dissemination of the infection from primary cell targets at olfactory, hippoc... |
MAp19, the alternative splice product of the MASP2 gene | Abstract The lectin pathway of complement is a central part of innate immunity, but as a powerful inducer of inflammation it needs to be tightly controlled. The MASP2 gene encodes two proteins, MASP-2 and MAp19. MASP-2 is the serine protease responsible for lectin pathway activation. The smaller alternative splice prod... |
Family‐centred care during a pandemic: The hidden impact of restricting family visits | |
Developing and testing a measure of COVID-19 Organizational Support of Healthcare Workers – Results from Peru, Ecuador, and Bolivia | During the COVID-19 pandemic, healthcare workers are facing high workloads with resource constraints and risk of virus exposure, and healthcare organizations need to support their healthcare workers to reduce their anxiety. Based on a recent 8-point framework of COVID-19 specific organization support, we devised a meas... |
Comparison of the Panther Fusion and Allplex assays for the detection of respiratory viruses in clinical samples | Respiratory viral infections are the most frequent clinical syndrome affecting both children and adults, and early detection is fundamental to avoid infection-related risks and reduce the healthcare costs incurred by unnecessary antibiotic treatments. In this study, performance characteristics of two commercial methods... |
MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract | |
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway | BACKGROUND: Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. We have previously shown that papain-like protease domain 2 (PLP2), a cata... |
Prediction of numbers of the accumulative confirmed patients (NACP) and the plateau phase of 2019-nCoV in China | In the present study, I propose a novel fitting method to describe the outbreak of 2019-nCoV in China. The fitted data were selected carefully from the non-Hubei part and Hubei Province of China respectively. For the non-Hubei part, the time period of data collection corresponds from the beginning of the policy of isol... |
Incidence of Deep Vein Thrombosis among non‐ICU Patients Hospitalized for COVID‐19 Despite Pharmacological Thromboprophylaxis | BACKGROUND: A remarkably high incidence of VTE has been reported among critically ill patients with COVID‐19 assisted in the Intensive Care Unit (ICU). However, VTE burden among non‐ICU patients hospitalized for COVID‐19 that receive guideline‐recommended thromboprophylaxis is unknown. OBJECTIVES: To determine the inci... |
A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal | A wide range of RNA viruses use programmed −1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a programmed −1 ribosomal frameshift could be used by the virus to produce a fu... |
Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus | The origin of severe acute respiratory syndrome-associated corona-virus (SARS-CoV) is still a matter of speculation, although more than one year has passed since the onset of the SARS outbreak. In this study, we implemented a 3-step strategy to test the intriguing hypothesis that SARS-CoV might have been derived from a... |
First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA | BACKGROUND: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA. METHODS: Patients w... |
Caution about early intubation and mechanical ventilation in COVID-19 | |
Quality control assessment for the PCR diagnosis of TBEV infections | |
The Sentinel System as the Main Influenza Surveillance Tool | Poland has implemented the influenza surveillance system called Sentinel as of 2004. The system consists of both epidemiological and virological surveillance. It is an important tool for monitoring the situation in the entire country, coordinated by the National Influenza Center situated at the National Institute of Pu... |
Treatment with Imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination | BACKGROUND: There is an urgent need to develop new innovative therapies for the control of advanced cancer. The combination of antigen-specific immunotherapy with the employment of immunomodulatory agents has emerged as a potentially plausible approach for the control of advanced cancer. METHODS: In the current study, ... |
Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation | AIMS: Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts. Here, we explore the nature, the time course, and the role of the complement system in this damage. METHODS: The... |
Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection | BACKGROUND: Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia. AIM: We investigated the human leukocyte antigen (HLA... |
Chloroquine cardiac effects and toxicity.A short update. | There is currently an increased interest in using the antimalarials chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as COVID-19. However, risks of cardiotoxic effects tend to limit their use. The effects of these drugs on the electrical and mechanical a... |
Prediction of conserved long-range RNA-RNA interactions in full viral genomes | Motivation: Long-range RNA-RNA interactions (LRIs) play an important role in viral replication, however, only a few of these interactions are known and only for a small number of viral species. Up to now, it has been impossible to screen a full viral genome for LRIs experimentally or in silico. Most known LRIs are cros... |
Chapter 17 Paramyxoviridae | Publisher Summary Members of the family Paramyxoviridae cause most devastating diseases of animals and humans. In particular, the viruses causing rinderpest, canine distemper, Newcastle disease, measles, and mumps have arguably caused more morbidity and mortality than any other single group of related viruses in histor... |
Mayo Clinic Strategies for COVID-19 Community Engagement With Vulnerable Populations | |
Neutrophil-to-Lymphocyte Ratio and Outcomes in Louisiana Covid-19 Patients | BACKGROUND: Due to the rapidly escalating number of cases and the low baseline of overall health in Louisiana, we sought to determine the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in hospitalized COVID patients in 2 major metropolitan areas with the highest prevalence of cases and exceedingly high ra... |
Anakinra for patients with COVID-19 – Authors' reply | |
Will the COVID-19 Epidemic Reshape Cardiology? | The emergence of the novel coronavirus infection (COVID-19) began a series of unparalleled changes in health care systems worldwide. In the United States, the rapid evolution of the epidemic poses unprecedented challenges to hospitals, medical staff, training programs, policy makers, and professional societies(1). For ... |
‘All In’: a pragmatic framework for COVID‐19 testing and action on a global scale | Current demand for SARS‐CoV‐2 testing is straining material resource and labor capacity around the globe. As a result, the public health and clinical community are hindered in their ability to monitor and contain the spread of COVID‐19. Despite broad consensus that more testing is needed, pragmatic guidance toward real... |
Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4 | Abstract Coronaviruses replicate their genomes in association with rearranged cellular membranes. The coronavirus nonstructural integral membrane proteins (nsps) 3, 4 and 6, are key players in the formation of the rearranged membranes. Previously, we demonstrated that nsp3 and nsp4 interact and that their co-expression... |
Challenges in the diagnosis of paediatric pneumonia in intervention field trials: recommendations from a pneumonia field trial working group | Summary Pneumonia is a leading killer of children younger than 5 years despite high vaccination coverage, improved nutrition, and widespread implementation of the Integrated Management of Childhood Illnesses algorithm. Assessing the effect of interventions on childhood pneumonia is challenging because the choice of cas... |
Genomic characterization and phylogenetic analysis of SARS‐COV‐2 in Italy | This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) isolated from three patients involved in the first outbreak of COVID‐19 in Lombardy, Italy. Early molecular epidemiological traci... |
Pseudotyping exosomes for enhanced protein delivery in mammalian cells | Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins and to facilitate their uptake by target cells. Here, we demonstra... |
A proposed role for the SARS‐CoV‐2 nucleocapsid protein in the formation and regulation of biomolecular condensates | To date, the recently discovered SARS‐CoV‐2 virus has afflicted >6.9 million people worldwide and disrupted the global economy. Development of effective vaccines or treatments for SARS‐CoV‐2 infection will be aided by a molecular‐level understanding of SARS‐CoV‐2 proteins and their interactions with host cell proteins.... |
Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) infection | Abstract The emergence of viral respiratory pathogens with pandemic potential, such as severe acute respiratory syndrome coronavirus (SARS-CoV), the pathogenic agent of Covid-19, represent a serious health problem worldwide. Respiratory viral infections are, in general, associated with cytokine production, inflammation... |
Development of a Conventional RT-PCR Assay for Rapid Detection of Porcine Deltacoronavirus with the Same Detection Limit as a SYBR Green-Based Real-Time RT-PCR Assay | Porcine deltacoronavirus (PDCoV) is a newly discovered coronavirus, which belongs to the family Coronaviridae. It causes watery diarrhea, vomiting, and dehydration in newborn piglets. A sensitive RT-PCR method is urgently required to detect PDCoV infection. In this study, we developed and evaluated a conventional RT-PC... |
In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus | Abstract Objective In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia. Methods There wer... |
Bovine Rhinitis Viruses Are Common in U.S. Cattle with Bovine Respiratory Disease | Bovine rhinitis viruses (BRV) are established etiological agents of bovine respiratory disease complex however little research into their epidemiology and ecology has been published for several decades. In the U.S., only bovine rhinitis A virus 1 (BRAV1) has been identified while bovine rhinitis A virus 2 (BRAV2) and b... |
Detection and analysis of clinical features of patients with different COVID‐19 types | OBJECTIVE: This study was designed to investigate the change of various indexes in patients with different types of coronavirus disease 2019 (COVID‐19). METHODS: 75 COVID‐19 patients were collected from the First Affiliated Hospital, Zhejiang University School of Medicine, and they were classified into moderate, severe... |
Elective surgeries during the COVID‐19 outbreak | |
An astrovirus frameshift signal induces ribosomal frameshifting in vitro | Expression of the astrovirus RNA-dependent RNA polymerase has been hypothesized to be regulated by (− 1) ribosomal frameshifting. Sequence analysis of the 70 nucleotide region between open reading frames 1a and 1b indicates the presence of a shifty heptamer consensus sequence and downstream sequences that may be needed... |
Jumping species—a mechanism for coronavirus persistence and survival | Zoonotic transmission of novel viruses represents a significant threat to global public health and is fueled by globalization, the loss of natural habitats, and exposure to new hosts. For coronaviruses (CoVs), broad diversity exists within bat populations and uniquely positions them to seed future emergence events. In ... |
Appropriate arrangement of cancer treatment after COVID-19 epidemic peaks in China | PURPOSE: COVID-19 is causing a lot of problems in health services around the world, especially in medical institutions receiving cancer patients. On March 12, China’s National Health Commission announced that the peak of the COVID-19 epidemic has passed in China. Thus, a proper arrangement of medication, surgery and ra... |
The evolving structure of the Southeast Asian air transport network through the lens of complex networks, 1979–2012 | Abstract This paper presents a novel approach to investigating and understanding the evolving structure of the Southeast Asian air transport network (SAAN) over the period 1979–2012. Our approach captures the main topological and spatial changes from a complex network perspective. We find that the SAAN combines a relat... |
The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker | The efficient synthesis of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker is described starting from diethyl azidomethyl-, 2-azidoethyl-, 3-azidopropyl-, 4-azidobutyl-, 2-azido-1-hydroxyethyl-, 3-azido-2-hydroxypropyl- and 3-azido-1-hydroxypropylphosphonates and selected alkynes under microwave... |
Electoral incentives to combat mosquito-borne illnesses: Experimental evidence from Brazil() | Mosquito-borne illnesses present significant health challenges to the developing world. If citizens are informed about their government’s efforts to combat these diseases, will they reward incumbents who have performed well and punish those who have done poorly at this task? Electoral sanctioning requires that combatti... |
Bartonella-associated inflammatory cardiomyopathy in a dog | Abstract A 6-year-old, male, mongrel dog was presented for acute onset of dyspnea and cough. At admission, the dog was cachectic and severely depressed. The electrocardiogram showed a sinus rhythm conducted with left bundle truncular branch block and interrupted by frequent multiform ventricular ectopic beats organized... |
Developing and Using Therapeutics for Emerging Infections | This issue of Clinical Pharmacology & Therapeutics focuses on emerging infections. The outbreaks of the vaccine‐preventable diseases (e.g., measles) and the emerging pathogens (e.g., Ebola) show us how small the world has become. These outbreaks also show the pressing need for effective public education and development... |
Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus | A multiplex polymerase chain reaction (mPCR) assay was developed to detect and distinguish feline panleukopenia virus (FPV), feline bocavirus (FBoV) and feline astrovirus (FeAstV). Three pairs of primers were designed based on conserved regions in the genomic sequences of the three viruses and were used to specifically... |
Gel-Filtration Chromatography | Gel-filtration chromatography is a versatile method that permits the effective separation of biological molecules in high yield. This article describes the basis of the method, the selection of suitable operating conditions, and contrasts typical matrix types. Applications of the technique are described, with reference... |
Epidemiological and genetic analysis of severe acute respiratory syndrome | Summary The severe acute respiratory syndrome (SARS) epidemics in 2002–2003 showed how quickly a novel infectious disease can spread both within communities and internationally. We have reviewed the epidemiological and genetic analyses that have been published both during and since these epidemics, and show how quickly... |
Resistance to synthetic blood penetration of National Institute for Occupational Safety and Health-approved N95 filtering facepiece respirators and surgical N95 respirators | BACKGROUND: Surgical N95 filtering facepiece respirators (FFRs), certified by the National Institute for Occupational Safety and Health (NIOSH) as a respirator and cleared by the Food and Drug Administration (FDA) as a surgical mask, are often used to protect from the inhalation of infectious aerosols and from splashes... |
Recommandations de la Société Française de Médecine du Travail (SFMT) : Avis relatif à l’affectation, dans le contexte de l’épidémie SARS-CoV-2 (Covid-19), des professionnels exerçant en milieu de soins et travailleurs assimilés, présentant un asthme. 7 avril 2020 | |
Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects | Thrombomodulin (TM) is a 557-amino acid protein with a broad cell and tissue distribution consistent with its wide-ranging physiological roles. When expressed on the lumenal surface of vascular endothelial cells in both large vessels and capillaries, its primary function is to mediate endothelial thromboresistance. The... |
Global Coronavirus Pandemic (SARS CoV‐2): Past, Present, And Future Of Pediatric Dermatology | Two months have passed since the World Health Organization (WHO) declared the pandemic of the Coronavirus Disease 19 (COVID‐19), caused by the SARS CoV‐2 virus, on March 11, 2020. Medical and healthcare workers have continued to be on the frontline to defeat this disease, however, continual changes are being made to th... |
Molecular Imaging of Influenza and Other Emerging Respiratory Viral Infections | Research on the pathogenesis and therapy of influenza and other emerging respiratory viral infections would be aided by methods that directly visualize pathophysiologic processes in patients and laboratory animals. At present, imaging of diseases, such as swine-origin H1N1 influenza, is largely restricted to chest radi... |
Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years | BACKGROUND: It is extremely important to objectively take a view of population health to provide useful information to decision makers, health-sector leaders, researchers, and informed citizens. This study aims to examine the burden of disease in Korea as of 2015, and to study how the burden of disease changes with the... |
Avril 2020 au GHR de Mulhouse entre SMUR et Réanimation: Au cœur de la pandémie COVID-19 | |
The rise of molecular simulations in fragment-based drug design (FBDD): an overview | Fragment-based drug discovery (FBDD) is an innovative approach, progressively more applied in the academic and industrial context, to enhance hit identification for previously considered undruggable biological targets. In particular, FBDD discovers low-molecular-weight (LMW) ligands (<300 Da) able to bind to therapeuti... |
Detection of pathogens in water: from phylochips to qPCR to pyrosequencing | Waterborne pathogens pose a significant threat to human health and a proper assessment of microbial water quality is important for decision making regarding water infrastructure and treatment investments and eventually to provide early warning of disease, particularly given increasing global disasters associated with s... |
Clinical signs, reproduction of attaching/effacing lesions, and enterocyte invasion after oral inoculation of an O118 enterohaemorrhagic Escherichia coli in neonatal calves | Abstract Attaching and effacing (AE) lesions are produced among others by enteropathogenic Escherichia coli and enterohaemorrhagic E. coli (EHEC), which differs from the former by the production of cytotoxins active on various cell cultures, the verocytotoxins, or shigacytotoxins. EHEC are associated with diarrhoea and... |
The COVID-19 pandemic: implications for the head and neck anesthesiologist | As the COVID-19 pandemic has unfolded, there has been growing recognition of risks to the anesthesia and surgical teams that require careful consideration to ensure optimal patient care. Airway management and other head and neck procedures risk exposure to mucosal surfaces, secretions, droplets, and aerosols that may h... |
Selective Inhibition of USP7 | The deubiquitinating enzyme USP7 is an emerging oncology and antiviral target. Reverdy et al., in this issue of Chemistry & Biology, disclose the first small-molecule inhibitor selective for USP7, which recapitulates its knockdown in cancer cells and hence demonstrates the therapeutic feasibility of USP7 inhibitors. |
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