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Genetic Characterization of Cryptosporidium parvum Isolates from Cattle in Portugal: Animal and Human Implications | |
Switching to teleconsultation for rheumatology in the wake of the COVID-19 pandemic: feasibility and patient response in India | The emergent COVID-19 pandemic dictates an urgent switch to teleconsultation. India has high patient to rheumatologist ratio, and patients have limited concepts about telemedicine. Thus, we attempted to find the feasibility and acceptance of patients in switching to teleconsultation. The CARE rheumatology clinic at Ker... |
First detection, clinical presentation and phylogenetic characterization of Porcine epidemic diarrhea virus in Austria | BACKGROUND: Porcine epidemic diarrhea (PED) is a syndrome that is characterized by rapidly spreading watery diarrhea affecting pigs of all ages, but with major effects on suckling piglets. The disease, as well as the causative Alphacoronavirus, the Porcine epidemic diarrhea virus (PEDV), was first described in Europe i... |
Challenges and Responses: A Tertiary Hospital in 2019-nCoV Epidemic | The recent outbreak of coronavirus in Wuhan, China, has imposed challenges on the Chinese medical system. Not only the dramatically increasing number of infected cases and insufficient medical resources, but also the peoples’ panic throughout the whole country have made medical services extremely difficult. To respond ... |
Early diagnosis of dengue disease severity in a resource-limited Asian country | BACKGROUND: Dengue is endemic throughout Cambodia, a country faced with significant health and economic challenges. We undertook a clinical study at the National Paediatric Hospital in Phnom Penh to evaluate clinical diagnostic parameters for dengue and predictors of disease outcome. METHODS: Between September 2011 and... |
Power and politics: the case for linking resilience to health system governance | |
Acute Hemorrhagic Edema of Infancy after Coronavirus Infection with Recurrent Rash | Purpura, particularly when accompanied by fever, is a worrisome finding in children. Acute hemorrhagic edema of infancy (AHEI) is a benign type of small-vessel leukocytoclastic vasculitis that presents with progressive purpura and has an excellent prognosis. Patients with AHEI present with large, target-like purpuric p... |
Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and their potential as vaccine vectors | Abstract Full-length infectious cDNA clones have recently become available for both European and North American genotypes of porcine reproductive and respiratory syndrome virus (PRRSV), and it is now possible to alter the PRRSV genome and create genetically defined mutant viruses. Among many possible applications of th... |
Bocavirus Viremia and Hepatitis in an Immunocompetent Child | BACKGROUND: So far, many studies have shown that Human Bocavirus ( HBoV) is the main pathogen of the respiratory tract. Until now, there is no study that proves the association between HBoV and hepatitis. HBoV viremia/DNAemia has been associated closely with acute primary infection and moderate-to-severe illness but, m... |
Disease X ver1.0: COVID-19 | The SARS-Cov2 has presented the world with a novel pandemic challenge requiring a rapid response. This article provides a May 2020 snapshot from Professor Paul Young, who is part of a group working with urgency on Australia’s leading COVID-19 candidate vaccine. |
Genetic Loci That Influence Cause of Death in a Heterogeneous Mouse Stock | A genome scan was conducted to seek evidence for polymorphic genes that influence cause of death in mice produced by a cross between CB6F1 females and C3D2F1 males. Loci on chromosomes 1 and 4 were found to modulate risk of lymphoma. A locus on chromosome 4 influenced risk of mammary adenocarcinoma among multiparous fe... |
Syndrome respiratoire aigu sévère | Résumé Le syndrome respiratoire aigu sévère (severe acute respiratory syndrome, SARS) est apparu à l’automne 2002 dans la province de Guangdong en Chine. L’épidémie s’est rapidement propagée à travers le monde pour toucher, courant avril, plus de 26 pays avec un total de cas à cette même date proche de 3500 cas. La sym... |
Keynote Lectures (KL) | |
The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series | Poly(ADP-ribosyl)ation is a post-translational modification of proteins that is mediated by poly(ADP-ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid-like molecule poly(ADP-ribose) (PAR) has been known for 40 years, understanding its biological functions—originally thought to be only t... |
Improving Preparedness for and Response to Coronavirus Disease 19 (COVID-19) in Long-Term Care Hospitals in Korea | Clusters of coronavirus disease 2019 (COVID-19) in long-term care facilities (LTCFs) have been widely reported in Korea and around the world. COVID-19 has a high mortality rate, and older patients and those with underlying diseases are at particularly high risk of being infected. Outbreaks in LTCFs, where many high-ris... |
Combined Antiviral-Antimediator Treatment for the Common Cold | A randomized, controlled, double-masked clinical trial was conducted with a combination antiviral-antimediator treatment for experimental rhinovirus colds. In all, 150 healthy men and women (aged 18–51 years) were randomly assigned to 1 of 3 groups: intranasal interferon (IFN)–α2b (6×10(6) U every 12 h × 3) plus oral c... |
Towards Stronger EU Governance of Health Threats after the COVID-19 Pandemic | |
The Role of Extracellular Vesicles as Allies of HIV, HCV and SARS Viruses | Extracellular vesicles (EVs) are lipid bilayer-enclosed entities containing proteins and nucleic acids that mediate intercellular communication, in both physiological and pathological conditions. EVs resemble enveloped viruses in both structural and functional aspects. In full analogy with viral biogenesis, some of the... |
A Probiotic-Based Sanitation System for the Reduction of Healthcare Associated Infections and Antimicrobial Resistances: A Budget Impact Analysis | Healthcare associated infections (HAIs) and antibiotic resistance have high social and economic burdens. Healthcare environments play an important role in the transmission of HAIs. The Probiotic Cleaning Hygiene System (PCHS) has been shown to decrease hospital surface pathogens up to 90% vs. conventional chemical clea... |
MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic | |
Functional Interplay between RNA Viruses and Non-Coding RNA in Mammals | Exploring virus–host interactions is key to understand mechanisms regulating the viral replicative cycle and any pathological outcomes associated with infection. Whereas interactions at the protein level are well explored, RNA interactions are less so. Novel sequencing methodologies have helped uncover the importance o... |
Development and verification of real-time PCR assay for identification of viral agents causing acute respiratory infections in human beings | A multiplex polymerase chain reaction (PCR) for identification of four viruses causing acute respiratory diseases in human beings was developed. The analytical sensitivity of developed RT-PCR for identification of adenovirus, respiratory-syncytial virus, flu viruses types A and B, and actual subtypes of type A flu viru... |
Online health information – what the newspapers tell their readers: a systematic content analysis | BACKGROUND: This study investigated the nature of newspaper reporting about online health information in the UK and US. Internet users frequently search for health information online, although the accuracy of the information retrieved varies greatly and can be misleading. Newspapers have the potential to influence publ... |
Re-Engineering Academic Departments of Obstetrics and Gynecology to Operate in a Pandemic World and Beyond – A Joint AGOS/CUCOG Statement | Abstract The COVID-19 pandemic has significantly disrupted operations in academic Departments of Obstetrics and Gynecology throughout the U.S. and will continue to impact them for the foreseeable future. It has also created an environment conducive to innovation and the accelerated implementation of new ideas. These de... |
Current smoking, former smoking, and adverse outcome among hospitalized COVID-19 patients: a systematic review and meta-analysis | BACKGROUND: The purpose of this study was to examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients. METHODS: A systematic review of the literature (PubMed) identified 18 (from a total of 1398) relevant studies. Pooled current smoking prevalence was compared with ... |
PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis | Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1(hi), tissue-resident memory popula... |
Monarch butterfly migration and parasite transmission in eastern North America | Seasonal migration occurs in many animal systems and is likely to influence interactions between animals and their parasites. Here, we focus on monarch butterflies (Danaus plexippus) and a protozoan parasite (Ophryocystis elektroscirrha) to investigate how host migration affects infectious disease processes. Previous w... |
Laboratory Tests for Diagnosis of Gastrointestinal and Pancreatic Diseases | The panel of laboratory tests available for diagnosis of gastrointestinal (GI) diseases in dogs and cats is wide, and, recently, several new tests have been developed. This article will focus on advances in laboratory tests that are available for the general practitioner for diagnosis of GI diseases. Laboratory tests f... |
Hemagglutination by Murine Hepatitis Viruses | Erythrocytes from twelve mammalian and avian sources in ten different buffers at three incubation temperatures could not be hemagglutinated with murine hepatitis virus (MHV) strains 3, A59, or S grown on DBT cells. Viral antigen preparation in the absence of fetal calf serum, partial virus purification, or various conc... |
When a global pandemic complicates cancer care: Although oncologists and their patients are accustomed to fighting tough battles against a lethal disease, Coronavirus Disease 2019 (COVID‐19) has posed an unprecedented challenge | |
The 2019-nCoV pandemic in the global south: A Tsunami ahead | |
Retroauricular dermatitis with vehement use of ear loop face masks during COVID19 pandemic | The COVID‐19 pandemic forged theexponential use of masks of various kinds, not just by health workers but also by general population as a personal protective equipment (PPE). Although contact dermatitis due to PPE is well reported, mask induced dermatitis is a relatively unexplored phenomenon. In this article, we repor... |
Characterization of a novel coronavirus responsible for severe acute respiratory syndrome | Abstract In February, a new avian H5N1/03 virus took two persons' lives in Hong Kong. After this incidence, a newly emerged disease has been identified, associated with pneumonia in infected patients. Here we report that a newly discovered coronoavirus (Cov) is responsible for this disease. In addition, the basic featu... |
Pneumopathies dites atypiques à coronavirus | Résumé La nouvelle pneumopathie, appelée pneumonie atypique, revêt dans 20 % de cas l’aspect d’une forme grave (severe acute respiratory syndrome, SARS). C’est parmi ces cas que l’on trouve surtout les 5 % de mortalité. C’est le diagnostic et le traitement tardif qui entraînent ces formes sévères. Il faut donc traiter ... |
Some simple rules for estimating reproduction numbers in the presence of reservoir exposure or imported cases | Abstract For many diseases, the basic reproduction number ( R 0 ) is a threshold parameter for disease extinction or survival in isolated populations. However no human population is fully isolated from other human or animal populations. We use compartmental models to derive simple rules for the basic reproduction numbe... |
The European Commission’s Task Force on Bioterrorism | In response to the increased threat of bioterrorism, a task force on health security was established in the European Commission. Task force members address a broad range of issues related to preparedness for and response to bioterrorist events and seek to bring about a greater collaboration between the European Union m... |
Actin- and clathrin-dependent mechanisms regulate interferon gamma release after stimulation of human immune cells with respiratory syncytial virus | BACKGROUND: Respiratory syncytial virus (RSV) can cause recurrent and severe respiratory tract infections. Cytoskeletal proteins are often involved during viral infections, either for cell entry or the initiation of the immune response. The importance of actin and clathrin dynamics for cell entry and the initiation of ... |
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein | Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesi... |
MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS | Abstract Several studies have been published describing the clinical and radiographic findings on the novel coronavirus (COVID-19) pneumonia. Therefore, there is currently a lack of pathologic data about its effects in intubated patients. Pneumothorax may occur rarely and results from a combination of fibrotic parenchy... |
Chest X-ray in new Coronavirus Disease 2019 (COVID-19) infection: findings and correlation with clinical outcome | AIM: The purpose of this study is to describe the main chest radiological features (CXR) of COVID-19 and correlate them with clinical outcome. MATERIALS AND METHODS: This is a retrospective study involving patients with clinical-epidemiological suspect of COVID-19 infection, who performed CXRs at the emergency departme... |
Fecal virome analysis of three carnivores reveals a novel nodavirus and multiple gemycircularviruses | BACKGROUND: More knowledge about viral populations in wild animals is needed in order to better understand and assess the risk of zoonotic diseases. In this study we performed viral metagenomic analysis of fecal samples from three healthy carnivores: a badger (Meles meles), a mongoose (Herpestes ichneumon) and an otter... |
Assessing Immune Response to SARS-CoV-2 Infection | |
Surgeons' response to COVID‐19 – Preparing from the sideline | |
Multisystem Inflammatory Syndrome in Children (MIS‐C) Related to COVID‐19: A New York City Experience | In December 2019, the 2019 novel coronavirus disease (COVID‐19) caused by Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as low risk for severe COVID‐19... |
The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins | The ability of a protein to fold into unique functional state or to stay intrinsically disordered is encoded in its amino acid sequence. Both ordered and intrinsically disordered proteins (IDPs) are natural polypeptides that use the same arsenal of 20 proteinogenic amino acid residues as their major building blocks. Th... |
Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling | Increasing research has demonstrated that expression of brain and muscle ARNT-like 1 (BMAL1) and other circadian clock genes can be regulated by drugs and toxicants. We previously demonstrated that icariin, extracted from Herba Epimedii, sromotes osteogenic differentiation. However, the mechanism underlying the associa... |
Independent validation of experimental results requires timely and unrestricted access to animal models and reagents | |
Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo | To investigate the potential of adeno-associated viruses serotype 2 (AAV2)-mediated RNA interference (RNAi) as an antiviral agent against rabies, recombinant AAV2 vectors expressing siRNA targeting the nucleoprotein (N) gene of rabies virus (RABV) (rAAV-N796) were constructed and evaluated. When NA cells pretreated wit... |
Diagnóstico microbiológico de las infecciones virales respiratorias | Acute respiratory infection is the most common disease occurring over a person's lifetime, with etiological variations determined mainly by age, environmental circumstances, the healthcare setting, and the underlying pathology. More than 200 different viruses distributed in six viral families have been implicated in th... |
Exposure to disease agents in the endangered Iberian lynx (Lynx pardinus) | The Iberian lynx (Lynx pardinus) is the most endangered felid species in the world. Lynx populations have decreased dramatically in size and distribution in the last four decades, thus becoming increasingly vulnerable to catastrophic events such as epizooties. From 1989 to 2000, serum samples were obtained from 48 free... |
Corona Virus Disease-19 (COVID-19) Presenting as Conjunctivitis: Atypically High-risk During a Pandemic | |
The viral etiology of an influenza‐like illness during the 2009 pandemic | Many viruses are known to cause influenza‐like illness (ILI); however, in nearly 50% of patients, the etiologic agent remains unknown. The distribution of viruses in patients with ILI was investigated during the 2009 A/H1N1 influenza pandemic (A/H1N1p). From June 2009 to January 2010, 660 patients with suspected influe... |
The impact of protein characterization in structural proteomics | Protein characterization plays a role in two key aspects of structural proteomics. The first is the quality assessment of the produced protein preparations. Obtaining well diffracting crystals is one of the major bottlenecks in the structure‐determination pipeline. Often, this is caused by the poor quality of the prote... |
Update on Bronchiolitis Obliterans Syndrome in Lung Transplantation | Lung transplantation has become an important therapeutic option for patients with end-stage organ dysfunction; however, its clinical usefulness has been limited by the relatively early onset of chronic allograft dysfunction and progressive clinical decline. Obliterative bronchiolitis is characterized histologically by ... |
BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment | Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected ... |
Glycan-Protein Interactions in Viral Pathogenesis | The surfaces of host cells and viruses are decorated by complex glycans, which play multifaceted roles in the dynamic interplay between the virus and the host including viral entry into host cell, modulation of proteolytic cleavage of viral proteins, recognition and neutralization of virus by host immune system. These ... |
COVID‐19: psychological issues for people with diabetes and health care staff | COVID‐19 has frightened us all. Not only are we at risk of a potentially fatal infection, but our governments’ efforts to protect us have separated us from our families and disrupted our lives. People with diabetes are especially vulnerable. Dr Rowan Hillson looks at lessons from past disasters and pandemics to highlig... |
The effect of latitude and PM(2.5) on spreading of SARS-CoV-2 in tropical and temperate zone countries() | The present work describes spreading of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) at the tropical and temperate zones which are explained based on insolation energy, Particulate Matter (PM(2.5)), latitude, temperature, humidity, Population Density (PD), Human Development Index (HDI) and Global Health... |
Development of ultrahigh‐performance liquid chromatography‐ mass spectrometry and ultrahigh‐performance supercritical fluid chromatography‐mass spectrometry assays to determine the concentration of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions | RATIONALE: Fast and easily transferable chromatography‐mass spectrometry assays were required to detect and quantify the amount of Bitrex™ and sodium saccharin in homemade facemask fit testing solutions. METHODS: Bitrex™ solutions were analysed using reversed phase ultrahigh‐performance liquid chromatography coupled wi... |
The pandemic characteristics of 2019-nCoV: case-control study for severity and geographic locations for 2019-nCoV epidemics worldwide | Using available official data we found 248 epidemics curves caused worldwide by the 2019-nCoV in the period December 2019–March 31st 2020. The analysis of this material allowed two main observations: 1) it is possible to describe the main geographical pathway of the diffusion of the virus in different directions. This ... |
Hyperammonemic encephalopathy in a pediatric patient with Salmonella enteritis and after Roux‐en‐Y surgery | |
Temporal rise in the proportion of younger adults and older adolescents among coronavirus disease (COVID-19) cases following the introduction of physical distancing measures, Germany, March to April 2020 | Using data on coronavirus disease (COVID-19) cases in Germany from the Robert Koch Institute, we found a relative increase with time in the prevalence in 15–34 year-olds (particularly 20–24-year-olds) compared with 35–49- and 10–14-year-olds (we excluded older and younger ages because of different healthcare seeking be... |
Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses | Abstract A novel biopolymeric material in the form of nano/microspheres was developed which was capable of adsorbing coronaviruses. The biopolymer was obtained by crosslinking of chitosan (CHIT) with genipin, a nontoxic compound of plant origin, in inverted emulsion and reacting the chitosan nano/microspheres obtained ... |
A Quick “Can I Donate Blood” Self-assessment Tool amid the COVID-19 Outbreak | Abstract When presenting with flu-like illnesses, the existing eligibility criteria set within the guidelines, bar such individuals from donating blood. All the same, when healthy-looking ‘asymptomatic’ rather 'innocent blood donors' [IBDs] come forward to donate blood, they’ll pose a serious threat to the health of th... |
Genetics-Based Classification of Filoviruses Calls for Expanded Sampling of Genomic Sequences | We have recently developed a computational approach for hierarchical, genome-based classification of viruses of a family (DEmARC). In DEmARC, virus clusters are delimited objectively by devising a universal family-wide threshold on intra-cluster genetic divergence of viruses that is specific for each level of the class... |
Child and adolescent mental health service provision and research during the Covid-19 pandemic: challenges, opportunities, and a call for submissions | |
A COVID-19 case report from asymptomatic contact: implication for contact isolation and incubation management | BACKGROUND: As of 2 March, 2020, at least 80 151 coronavirus disease 2019 (COVID-19) cases were reported in China. Most of the patients had a history of visiting Hubei Province or contacting with people who had ever stayed in or passed by Hubei Province or were exposed to symptoms. Some patients got infected through on... |
Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19 | The new Coronavirus (SARS-CoV-2) is the cause of a serious infection in the respiratory tract called COVID-19. Structures of the main protease of SARS-CoV-2 (M(pro)), responsible for the replication of the virus, have been solved and quickly made available, thus allowing the design of compounds that could interact with... |
Using the contact network model and Metropolis-Hastings sampling to reconstruct the COVID-19 spread on the “Diamond Princess” | Abstract Traditional compartmental models such as SIR (susceptible, infected, recovered) assume that the epidemic transmits in a homogeneous population, but the real contact patterns in epidemics are heterogeneous. Employing a more realistic model that considers heterogeneous contact is consequently necessary. Here, we... |
Diffuse Alveolar Damage: A Common Phenomenon in Progressive Interstitial Lung Disorders | It has become obvious that several interstitial lung diseases, and even viral lung infections, can progress rapidly, and exhibit similar features in their lung morphology. The final histopathological feature, common in these lung disorders, is diffuse alveolar damage (DAD). The histopathology of DAD is considered to re... |
Covid-19 spreads in US | Multiple outbreaks worldwide have led to countries stepping up their responses. By Debora MacKenzie and Press Association |
RANTES, Macrophage-Inhibitory Protein 1α, and the Eosinophil Product Major Basic Protein Are Released into Upper Respiratory Secretions during Virus-Induced Asthma Exacerbations in Children | The presence of cytokines and the toxic eosinophil granule product major basic protein (MBP) was investigated in nasal aspirates from children with naturally occurring virus-induced asthma exacerbations and compared with levels in nasal aspirates taken from the same children when asymptomatic. Increased levels of MBP a... |
Infecciones virales de vías respiratorias en los primeros seis meses de vida | Resumen Antecedentes El virus respiratorio sincitial (VRS) y otros virus son causas conocidas de hospitalización en lactantes. Menos conocido es el patrón de virus en infecciones extrahospitalarias en menores de 6 meses. Objetivo El objetivo de este estudio es describir las características clínicas y los factores epide... |
New targets for treatment against HCV infection | Owing to the tremendous effort from both academia and industry, drug development for hepatitis C virus (HCV) infection has been flourishing, with a range of pipeline compounds at various stages of development. Although combination of the recently launched serine protease inhibitors will further improve the response rat... |
SENEGAL: Force‐Covid‐19 | |
Sequence Comparison of Avian Infectious Bronchitis Virus S1 Glycoproteins of the Florida Serotype and Five Variant Isolates from Georgia and California | The infectious bronchitis virus (IBV) spike glycoprotein S1 subunit is required to initiate infection and contains virus-neutralizing and serotype-specific epitope(s). Reported are the S1 gene nucleotide and predicted amino acid sequences for the Florida 18288 strain and isolates GA-92, CV-56b, CV-9437, CV-1686, and 10... |
An approximation-based approach for periodic estimation of effective reproduction number: a tool for decision-making in the context of Covid-19 outbreak | Abstract Objectives The effective reproduction number (R) is a more practical epidemiological parameter than basic reproduction number (R 0 ) for characterization of infectious disease epidemics as it takes into account presence of immune individuals in the population which R 0 does not. Periodic assessment of R can in... |
Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide | Abstract We report a coronavirus disease 2019 (COVID-19) case with rheumatoid arthritis taking iguratimod. The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-... |
Recurrent positive nucleic acid detection in a recovered COVID-19 patient: a case report and literature review | OBJECTIVE: To describe a case of recurrent positive nucleic acid detection in a recovered coronavirus disease 2019 (COVID-19) patient and to provide clinical data for the further study of COVID-19. METHODS: A case of COVID-19 was retrospectively analyzed, and the relevant literature was reviewed. RESULTS: Based on the ... |
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation | The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a ... |
Reassortant Group A Rotavirus from Straw-colored Fruit Bat (Eidolon helvum) | Bats are known reservoirs of viral zoonoses. We report genetic characterization of a bat rotavirus (Bat/KE4852/07) detected in the feces of a straw-colored fruit bat (Eidolon helvum). Six bat rotavirus genes (viral protein [VP] 2, VP6, VP7, nonstructural protein [NSP] 2, NSP3, and NSP5) shared ancestry with other mamma... |
Demographic and Socioeconomic Disparities Among Cancer Survivors in Clinical Trials Participation, USA, 2016–2018 | The established findings of lower representation of minority population in clinical trials are skewed by the national representation of the US population by race where they account only for 30%, making it difficult to compare the participation rate by race. We report the direct age-adjusted demographic and socioeconomi... |
Spontaneous breathing, transpulmonary pressure and mathematical trickery | |
Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis | Coronavirus disease 2019 (COVID-19) has resulted in considerable morbidity and mortality worldwide since December 2019. In order to explore the effects of comorbid chronic diseases on clinical outcomes of COVID-19, a search was conducted in PubMed, Ovid MEDLINE, EMBASE, CDC, and NIH databases to April 25, 2020. A total... |
Interactions of Pathogens with the Host | Abstract Infection occurs when a microbe enters a normally nonsterile tissue and may cause an infectious disease with signs and symptoms or a subclinical infection. Infections that are not cleared by the host are characterized as persistent. The agent in nonreplicating or latent infection may begin to grow again or to ... |
Thermostable DNA Polymerase from a Viral Metagenome Is a Potent RT-PCR Enzyme | Viral metagenomic libraries are a promising but previously untapped source of new reagent enzymes. Deep sequencing and functional screening of viral metagenomic DNA from a near-boiling thermal pool identified clones expressing thermostable DNA polymerase (Pol) activity. Among these, 3173 Pol demonstrated both high ther... |
The critical bedside role in identifying and treating lung injury during the COVID‐19 pandemic | |
How to avoid nosocomial spread during tracheostomy for COVID‐19 patients | As the novel coronavirus (Covid-19) globally spreads, the Covid-19 pandemic is straining healthcare workers worldwide. In hospitalized patients with severe Covid-19, endotracheal intubation is one of the most common and indispensable life-saving interventions. For patients in need of long-term endotracheal intubation, ... |
Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton | Abstract A water-soluble extract of fermented Polygonum tinctorium Aiton (Polygonaceae) called Sukumo, exhibited a potent inhibitory activity against HIV type 1 in vitro. The extract potently suppressed acute HIV-1 (IIIB) infection in MT-4 cells with EC50 values of 0.5μg/ml but exhibited low cytotoxicity to MT-4 cells ... |
LIST OF CONTENTS, AUTHOR AND SUBJECT INDEX FOR VOLUME 43, 2006 | |
Aspects médico-psychologiques relatifs à l’épidémie de coronavirus (Covid-19) : l’apport de la théorie de la détection du signal et du concept de lieu de contrôle | |
Covid‐19‐related pancreatic injury | |
Governing Under Pressure: German Policy Making During the Coronavirus Crisis | The global threat of the coronavirus pandemic has forced policy makers to react quickly with totally new policy‐making approaches under conditions of uncertainty. This article focuses on such crisis‐driven policy learning, examining how the experiences of China and South Korea as early responder states influenced the s... |
Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1 | RNA helicases of the DEAD-box protein family form the largest group of helicases. The human DEAD-box protein 1 (DDX1) plays an important role in tRNA and mRNA processing, is involved in tumor progression and is also hijacked by several virus families such as HIV-1 for replication and nuclear export. Although important ... |
Renal hypouricemia is an ominous sign in patients with severe acute respiratory syndrome | Background: The purpose of this study is to determine the incidence and significance of hypouricemia in patients with severe acute respiratory syndrome (SARS). Pulmonary lesions in patients with SARS are thought to result from proinflammatory cytokine dysregulation. Acute renal failure has been reported in patients wit... |
Public health education for parents during the outbreak of COVID-19: A rapid review | Background: It is well-known that public health education plays a crucial role in the prevention and control of emerging infectious diseases, but how health providers should advise families and parents to obtain health education information is a challenging question. With coronavirus disease 2019 (COVID-19) spreading a... |
Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV): Revision of screening strategies urgently needed | Abstract Objectives Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause frequent hospital outbreaks in Saudi Arabia, with emergency departments as the initial site of the spread of this virus. Methods The risk of transmission of MERS-CoV infection to healthcare workers (HCWs) was assessed in an o... |
Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards | Background. The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) outside the Middle East occurred in South Korea in 2015 and resulted in 186 laboratory-confirmed infections, including 36 (19%) deaths. Some hospitals were considered epicenters of infection and voluntarily shut down most of the... |
Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants | The use of plants for medicinal purposes dates back thousands of years but genetic engineering of plants to produce desired biopharmaceuticals is much more recent. As the demand for biopharmaceuticals is expected to increase, it would be wise to ensure that they will be available in significantly larger amounts, on a c... |
Viral respiratory infections in a nursing home: a six-month prospective study | BACKGROUND: The knowledge on viral respiratory infections in nursing home (NH) residents and their caregivers is limited. The purpose of the present study was to assess and compare the incidence of acute respiratory infections (ARI) in nursing home (NH) residents and staff, to identify viruses involved in ARI and to co... |
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