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Robot assisted surgery during the COVID-19 pandemic, especially for gynecological cancer: a statement of the Society of European Robotic Gynaecological Surgery (SERGS) | All surgery performed in an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, irrespective of the known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status of the patient, should be regarded as high risk and protection of the surgical team at the bedside should be at the highes... |
Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A global pandemic and treatments strategies | The emergence and rapid spread of novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a potentially fatal disease is swiftly evolving public health crises worldwide. The origin of SARS-CoV-2 infection was first reported in people exposed to wet animal market in... |
Analysis of Public Perception of the Israeli Government’s Early Emergency Instructions Regarding COVID-19: Online Survey Study | BACKGROUND: On March 11, 2020, the World Health Organization (WHO) officially declared coronavirus disease (COVID-19) to be a pandemic. This posed challenges to many countries, prominent among which is communication with the public to gain their cooperation. Israel faces different challenges from other countries in its... |
Assessment of ambulance dispatch data for surveillance of influenza-like illness in Melbourne, Australia | Summary Objectives Ambulance dispatch data are collated electronically in many jurisdictions and have a wide reach into the community. They may therefore be useful for syndromic surveillance and early recognition of emerging infectious diseases. This study assessed whether ambulance dispatch data are suitable for influ... |
Safe surgery during the coronavirus disease 2019 crisis | BACKGROUND: Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has created a global pandemic. Surgical care has been impacted, with concerns raised around surgical safety, especially in terms of laparoscopic versus open surgery. Due to potential aerosol transmis... |
A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure | Abstract Recent studies suggest that some RNA-binding proteins facilitate the folding of non-cognate RNAs. Here, we report that bacteriophage MS2 coat protein (MS2 CP) bound and promoted the catalytic activity of Candida group I ribozyme. Cloning of the MS2-bound RNA segments showed that this protein primarily interact... |
13 General Mechanisms of Antiviral Resistance | This review explores the broad mechanisms of virus resistance. This will go beyond the generally accepted concept of antiviral resistance by summarizing those evolutionary outcomes that have enabled human viruses to resist mankind’s best efforts at control. The review then focuses on how viruses acquire resistance to c... |
Facing two deadly viruses | As covid-19 begins to take hold, the Democratic Republic of the Congo has detected its first new Ebola cases in months, reports Peter Yeung |
Testing Asymptomatic Emergency Department Patients for Coronavirus of 2019 (COVID‐19) in a Low Prevalence Region | The first cases of Coronavirus of 2019 (COVID‐19) were reported in Wuhan, China in December 2019(1). The literature demonstrates geographical variation with regards to estimates of infection incidence, suggesting that COVID‐19 has been underdiagnosed in certain regions(2,3). The rate of asymptomatic infection has been ... |
Management of Aerosol during Noninvasive Ventilation for Patients with Sleep-Disordered Breathing: Important Messages during the COVID-19 Pandemic | With the advent of COVID-19 infection and its rapid spread, preventive strategies are being developed worldwide, besides following the universal infection control guidelines. Prevention of spread through aerosol generation is one of the essential strategies in this regard, particularly for patients with sleep-disordere... |
COVID-19 energy sector responses in Africa: A review of preliminary government interventions | The COVID-19 pandemic has unleashed unprecedented shocks across all facets of society, from strained healthcare systems to the closure of schools and economies. The energy sector is of no exception, with several concerns being raised about the ramifications that will arise for the clean energy transition. The goal of o... |
Assessment of Hospital Emergency Department Response to Potentially Infectious Diseases Using Unannounced Mystery Patient Drills—New York City, 2016 | |
Clinical Performance of Two SARS-CoV-2 Serologic Assays | BACKGROUND: The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a rapid proliferation of serologic assays. However, little is known about their clinical performance. Here, we compared two commercial SARS-CoV-2 IgG assays. METHODS: 103 specimens from 48 patients with PCR ... |
‘Age and Ageism in COVID-19’: Elderly Mental Health-care Vulnerabilities and Needs | |
Bréve : AIDS2020/Conférence internationale du sida | |
A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike | Continuously emerging highly pathogenic human coronaviruses (HCoVs) remain a major threat to human health, as illustrated in past SARS-CoV and MERS-CoV outbreaks. The development of a drug with broad-spectrum HCoV inhibitory activity would address this urgent unmet medical need. Although previous studies have suggested... |
Global health is more than just ‘Public Health Somewhere Else’ | |
QT Interval and Arrhythmic Safety of Hydroxychloroquine Monotherapy in Coronavirus Disease 2019 | BACKGROUND: Observational studies have suggested increased arrhythmic and cardiovascular risk with the combination use of hydroxychloroquine (HCQ) and azithromycin in patients with coronavirus disease 2019 (COVID-19). OBJECTIVE: The arrhythmic safety profile of HCQ monotherapy, which remains under investigation as a th... |
Tackling Corona Virus Disease 2019 (COVID 19) in Workplaces | Coronaviruses are zoonotic viruses and six species of Coronaviruses are known to cause human disease such as cause common cold, severe acute respiratory syndrome and the Middle East Respiratory Syndrome. In January 2020, scientists in Wuhan, China isolated a novel coronavirus (SARS-CoV-2), responsible for an outbreak o... |
Management of Venous Thromboembolism During the COVID-19 Pandemic | |
On-farm biosecurity as perceived by professionals visiting Swedish farms | BACKGROUND: On-farm biosecurity is an important part of disease prevention and control, this applies to live animal contacts as well as indirect contacts e.g. via professionals visiting farms in their work. The objectives of this study were to investigate how professionals visiting animal farms in Sweden in their daily... |
Total phenolic content and biological activities of enzymatic extracts from Sargassum muticum (Yendo) Fensholt | Seaweeds are potentially excellent sources of bioactive metabolites that could represent useful leads in the development of new functional ingredients in pharmaceutical and cosmetic industries. In the last decade, new marine bioprocess technologies have allowed the isolation of substances with biological properties. Th... |
A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka | OBJECTIVES: The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyn... |
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome | SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory tract disease (COVID-19). In some patients the infection results in moderate to severe acute respiratory distress syndrome (ARDS), requiring invasive mechanical ventilation. High serum levels of IL-6, IL-10 and an immune hyperresp... |
Detection of SARS Coronavirus RNA in the Cerebrospinal Fluid of a Patient with Severe Acute Respiratory Syndrome | |
FAQ relatives à la responsabilité du médecin du travail face au Covid-19 | |
Molecular evidence of tissue renin-angiotensin systems: A focus on the brain | Hypertension remains one of the largest human health problems, because hypertensive patients carry increased risk for ischemic heart disease, stroke, atherosclerosis, and renal failure. The renin-angiotensin system (RAS) has been intensively investigated for more than 100 years because it is a powerful regulator of blo... |
The association between self-perceived proficiency of personal protective equipment and objective performance: An observational study during a bioterrorism simulation drill | BACKGROUND: The recent Ebola virus disease outbreak emphasized the potential misuse of personal protective equipment (PPE) by health care workers (HCWs) during such an event. We aimed to compare self-perceived proficiency of PPE use and objective performance, and identify predictors of low compliance and PPE misuse. ME... |
Manipulation of human history by microbes | The convergence of the microbial and human worlds provides us with everyday essentials for the survival of our species, and in turn, this interaction brings painful and tragic consequences from pathogens. Looking back, it can be seen that microbes have also changed our history. Were it not for a pathogen that halted an... |
Vitamin D supplementation in the COVID-19 pandemic | |
Maternal mental health in the time of the COVID‐19 pandemic | With the pandemic of Coronavirus disease‐19 (COVID‐19) spiraling out of control, the world is desperately frazzled at the moment. A few empirical studies related to this pandemic have reported higher prevalence of mental health problems among women compared to men.(1) In this context, pregnant women and new mothers cou... |
Par rapport à la vancomycine, le linézolide améliore la guérison et la survie des patients atteints de pneumonias nosocomiales à Staphylococcus aureus méthicilline-résistant (SAMR) R.G. Wunderin | Unknown |
Worrying decrease in hospital admissions for myocardial infarction during the COVID-19 pandemic | Summary Background: How coronavirus 2019 (COVID-19) is affecting management of myocardial infarction is a matter of concern, as medical resources have been massively reorientated and the population has been in lockdown since 17 March 2020 in France. Aims: To describe how lockdown has affected the evolution of the weekl... |
Balancing infection control and frailty prevention during and after the COVID‐19 pandemic: Introduction of the NCGG Home Exercise Program for Older People 2020 | |
Guiding airway management and PPE for COVID-19 intubating teams | |
A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells | The respiratory syndrome caused by a new type of coronavirus has been emerging from China and caused more than 1000 death globally since December 2019. This new virus, called 2019 novel coronavirus (2019-nCoV) uses the same receptor called Angiotensinconverting enzyme 2 (ACE2) to attack humans as the coronavirus that c... |
The COVID-19 Pandemic: A Month of Bioethics in Finland | Finland’s first COVID-19 infection was recorded in late January 2020. The person infected was a tourist from China in Lapland. Authorities recommended regular handwashing, coughing in one’s sleeve, not touching your face, physical distancing, and home lockdown for those at risk. The pandemic spread at different paces i... |
A Mouse Model for MERS Coronavirus Induced Acute Respiratory Distress Syndrome | Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that emerged in 2012, causing acute respiratory distress syndrome (ARDS), severe pneumonia-like symptoms, and multi-organ failure, with a case fatality rate of ~36%. Limited clinical studies indicate that humans infected with MERS-CoV exhibited pa... |
Gulf War Servicemen and Servicewomen: The Long Road Home and the Role of Health Care Professionals to Enhance the Troops' Health and Healing | |
21 New developments in safety testing of soft fruits | Abstract: The chapter begins by establishing the definition of soft fruit, then discusses microbial and chemical hazards that might be found in soft fruit. Methods developed for virus detection in soft fruit are reviewed and, finally, the factors that mainly affect virus detection are detailed as these pathogens are cu... |
In Silico Analysis of ORF1ab in Coronavirus HKU1 Genome Reveals a Unique Putative Cleavage Site of Coronavirus HKU1 3C‐Like Protease | Recently we have described the discovery and complete genome sequence of a novel coronavirus associated with pneumonia, coronavirus HKU1 (CoV‐HKU1). In this study, a detailed in silico analysis of the ORF1ab, encoding the 7,182‐amino acid replicase polyprotein in the CoV‐HKU1 genome showed that the replicase polyprotei... |
A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019‐nCoV) | During an outbreak of respiratory diseases including atypical pneumonia in Wuhan, a previously unknown β‐coronavirus was detected in patients. The newly discovered coronavirus is similar to some β‐coronaviruses found in bats but different from previously known SARS‐CoV and MERS‐CoV. High sequence identities and similar... |
Microbiological control in stem cell banks: approaches to standardisation | The transplant of cells of human origin is an increasingly complex sector of medicine which entails great opportunities for the treatment of a range of diseases. Stem cell banks should assure the quality, traceability and safety of cultures for transplantation and must implement an effective programme to prevent contam... |
Lessons learnt from implementation of the International Health Regulations: a systematic review | OBJECTIVE: To respond to the World Health Assembly call for dissemination of lessons learnt from countries that have begun implementing the International Health Regulations, 2005 revision; IHR (2005). METHODS: In November 2015, we conducted a systematic search of the following online databases and sources: PubMed®, Emb... |
Development of Lectin-Linked Immunomagnetic Separation for the Detection of Hepatitis A Virus | The accuracy and sensitivity of PCR-based methods for detection of hepatitis A virus (HAV) are dependent on the methods used to separate and concentrate the HAV from the infected cells. The pH and ionic strength affect the binding affinity of the virus to cells. In this study, we initially investigated the effects of p... |
Disease features of equine coronavirus and enteric salmonellosis are similar in horses | BACKGROUND: Equine coronavirus (ECoV) is an emerging pathogen associated with fever and enteric disease in adult horses. Clinical features of ECoV infection have been described, but no study has compared these features to those of Salmonella infections. OBJECTIVES: Compare the clinical features of ECoV infection with e... |
Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus | Abstract Feline coronavirus infection can progress to a fatal infectious peritonitis, which is a widespread feline disease without an effective vaccine. Generating feline cells with reduced ability to respond to interferon (IFN) is an essential step facilitating isolation of new candidate vaccine strains. Here, we desc... |
The RNA shapes studio | Motivation: Abstract shape analysis, first proposed in 2004, allows one to extract several relevant structures from the folding space of an RNA sequence, preferable to focusing in a single structure of minimal free energy. We report recent extensions to this approach. Results: We have rebuilt the original RNAshapes as ... |
From SARS to pandemic influenza: the framing of high-risk populations | The 2003 global outbreak of severe acute respiratory syndrome (SARS) was a wake-up call for health systems in Canada, with realization of occupational health risks faced by health care workers and first responders in public health emergency response. The need for investment in critical social infrastructure—including e... |
Discovery of a missing disease spreader | This study presents a method to discover an outbreak of an infectious disease in a region for which data are missing, but which is at work as a disease spreader. Node discovery for the spread of an infectious disease is defined as discriminating between the nodes which are neighboring to a missing disease spreader node... |
Cytochemical identification of callose deposits around plasmodesmaia of virus-infected phloem cells | |
Covid-19 health crisis management in Europe: decisive assessment is needed now | |
Awake Prone Positioning for Non-intubated Oxygen Dependent COVID-19 Pneumonia Patients | Oxygenation failure recalcitrant to increasing positive end-expiratory pressure is a feature of severe coronavirus disease 2019 (COVID-19) pneumonia [1]. A Chinese group [2] used prone positioning to improve oxygenation for intubated patients with severe COVID-19 pneumonia. However, prone positioning in unconscious pat... |
Structural proteins of bovine coronavirus strain L9: effects of the host cell and trypsin treatment | The polypeptide profile of the cell-adapted strain of bovine coronavirus (Mebus BCV-L9) is remarkably affected by the host cell and trypsin. We compared the structural proteins of virus purified from different cell lines and found cell-dependent differences in the virus structure. BCV was purified from four clones of h... |
COVID-19: implications for immunosuppression in kidney disease and transplantation | The coronavirus disease 2019 (COVID-19) pandemic poses important challenges to the care of patients with immune-mediated kidney diseases and to kidney transplant recipients. Here, we discuss the management of immunosuppression for these patients during the pandemic and suggest potential approaches that could be conside... |
Chinese Public's Attention to the COVID-19 Epidemic on Social Media: Observational Descriptive Study | BACKGROUND: Since the coronavirus disease (COVID-19) epidemic in China in December 2019, information and discussions about COVID-19 have spread rapidly on the internet and have quickly become the focus of worldwide attention, especially on social media. OBJECTIVE: This study aims to investigate and analyze the public’s... |
The Era of Human-Induced Diseases | |
Rapid diagnostic test for respiratory infections | Abstract Acute respiratory infections are the second cause of morbidity and mortality in children and adults worldwide, being viruses, bacteria and fungi involved in their aetiology. The rapid diagnosis allows for a better clinical management of the patient, for adopting public health measures and for controlling possi... |
Severe Acute Respiratory Syndrome – a New Coronavirus from the Chinese Dragon's Lair | The recent identification of a novel clinical entity, the severe acute respiratory syndrome (SARS), the rapid subsequent spread and case fatality rates of 14–15% have prompted a massive international collaborative investigation facilitated by a network of laboratories established by the World Health Organization (WHO).... |
Low-tech solutions for the COVID-19 supply chain crisis | A global effort is ongoing in the scientific community and in the maker movement, which focuses on creating devices and tinkering with them, to reverse-engineer commercial medical equipment and get it to healthcare workers. For these ‘low-tech’ solutions to have a real impact, it is important for them to coalesce aroun... |
ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN | Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is a binding receptor for hepatitis C virus (HCV). Binding of HCV envelope protein E2 to target cells is a prerequisite to DC-SIGN-mediated signaling. Using cell lines with stable or transient expression of DC-SIGN, we investigated... |
Big-game hunting in the history of epidemics Frank Snowden | Unknown |
Systematic Review and Meta-Analysis of the Persistence and Disinfection of Human Coronaviruses and Their Viral Surrogates in Water and Wastewater | [Image: see text] A systematic review and meta-analysis was conducted to identify decay rate constants (k) of human coronaviruses and their viral surrogates (i.e., animal coronaviruses and the enveloped bacteriophage Phi6) in water and wastewater and disinfection rates with exposure to free chlorine and germicidal ultr... |
DRESS syndrome in a patient with SARS-CoV-2 disease | |
Atypical SARS in Geriatric Patient | We describe an atypical presentation of severe acute respiratory syndrome (SARS) in a geriatric patient with multiple coexisting conditions. Interpretation of radiographic changes was confounded by cardiac failure, with resolution of fever causing delayed diagnosis and a cluster of cases. SARS should be considered even... |
Synthetic viruses: a new opportunity to understand and prevent viral disease | Rapid progress in DNA synthesis and sequencing is spearheading the deliberate, large-scale genetic alteration of organisms. These new advances in DNA manipulation have been extended to the level of whole-genome synthesis, as evident from the synthesis of poliovirus, from the resurrection of the extinct 1918 strain of i... |
Rich at risk: socio-economic drivers of COVID-19 pandemic spread | COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and the health systems at large. While proper treatments are being developed, in-depth studies concerning its way o... |
A novel hierarchical clustering algorithm for gene sequences | BACKGROUND: Clustering DNA sequences into functional groups is an important problem in bioinformatics. We propose a new alignment-free algorithm, mBKM, based on a new distance measure, DMk, for clustering gene sequences. This method transforms DNA sequences into the feature vectors which contain the occurrence, locatio... |
Features of enteric disease from human coronaviruses: Implications for COVID‐19 | Coronaviruses have long been studied in both human and veterinary fields. Whereas the initial detection of endemic human respiratory coronaviruses was problematic, detection of these and newly discovered human coronaviruses has been greatly facilitated with major advances in the laboratory. Nevertheless, technological ... |
Interplay of global multi-scale human mobility, social distancing, government interventions, and COVID-19 dynamics | This work quantifies the impact of interventions to curtail mobility and social interactions in order to control the COVID-19 pandemic. We analyze the change in world-wide mobility at multiple spatio-temporal resolutions -- county, state, country -- using an anonymized aggregate mobility map that captures population fl... |
Detection of Adeno-Associated Virus Viremia in Hematopoietic Cell Transplant Recipients | Adeno-associated virus (AAV) is widely considered to be nonpathogenic, but the clinical epidemiology of this virus is limited. By use of polymerase chain reaction assays, we investigated the incidence and clinical significance of AAV viremia in a population of consecutive recipients of a hematopoietic cell transplant (... |
The Discomfort of Death Counts: Mourning through the distorted lens of reported COVID-19 death data | Summary In data science, there's long been an acknowledgment of the way data can flatten and dehumanize the people it represents - this limitation becomes most obvious when considering the pure inability of such numbers and figures to truly capture the reality of lives lost. |
Movement Disorders in the World of COVID-19. | |
Health and Economy in COVID-19 Era: A Plan for Reconstituting Long-Term Economic Security | COVID-19 is a rapidly evolving pandemic, which represents a multifaceted global threat. Given the economic consequences, most researchers agree that social distancing measures are an effective strategy relative to the cost. Previous studies indicate that community size as well as viral population risk groups should be ... |
Impact of SARS on Avian Influenza Preparedness in Healthcare Workers | BACKGROUND: SARS was an unprecedented outbreak which brought about 1,755 infections and 302 deaths in Hong Kong. The similarity of SARS and avian influenza prompted us to examine the relationship between SARS experience and preparedness on a potential avian influenza outbreak. METHODS: A self-administered questionnaire... |
Evaluation of COVID-19 epidemic outbreak caused by temporal contact-increase in South Korea | OBJECTIVES: On March 15, 2020, 61.3% of the confirmed cases of COVID-19 infection are associated with the worship service that was organized on February 9 in the Shincheonji Church of Jesus in Daegu, South Korea. In this study, we aim to evaluate the effects of mass infection in South Korea and assess the preventive co... |
Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design | The causative agent of severe acute respiratory syndrome (SARS) is a previously unidentified coronavirus, SARS-CoV. The RNA-dependent RNA polymerase (RdRp) of SARS-CoV plays a pivotal role in viral replication and is a potential target for anti-SARS therapy. There is a lack of structural or biochemical data on any coro... |
Reduced likelihood of bovine coronavirus and bovine respiratory syncytial virus infection on organic compared to conventional dairy farms | Abstract The prevalence of antibodies to bovine coronavirus (BCV) and bovine respiratory syncytial virus (BRSV) infections was studied in 20 conventional and 20 organic dairy herds. The organic farms had produced ‘certified’ milk for at least 2 years. On two occasions, with a 1-year interval, 699 serum samples from 624... |
Cohort Profile: The Flu Watch Study | |
Time-calibrated phylogenomics of the porcine epidemic diarrhea virus: genome-wide insights into the spatio-temporal dynamics | Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea (PED), has led to tremendous economic losses in the global swine industry. Although the phylogeny of PEDV has been investigated extensively at the molecular level, there was no time-calibrated phylogenomic study on the virus. To im... |
Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity | The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infection... |
Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox | Vaccination is highly effective in preventing various infectious diseases, whereas the constant threat of new emerging pathogens necessitates the development of innovative vaccination principles that also confer rapid protection in a case of emergency. Although increasing evidence points to T cell immunity playing a cr... |
Epidemiological Profile and Clinical Associations of Human Bocavirus and Other Human Parvoviruses | BackgroundHuman bocavirus (HBoV) and PARV4 are newly discovered human parvoviruses. HBoV, which was first detected in respiratory samples, has a potential role in the development of human respiratory disease. The present study compared the frequencies, epidemiological profiles, and clinical backgrounds of HBoV and PARV... |
Preventing airborne infection with an intranasal cellulose powder formulation (Nasaleze Travel®) | A total of 52 volunteers were recruited to take part in a dual-centered, randomized, blinded study so investigators could determine whether the level of airborne infection could be significantly reduced in patients randomly assigned to treatment with either Nasaleze® cellulose extract alone or a combination of Nasaleze... |
Preparation of a radiology department in an Italian hospital dedicated to COVID-19 patients | Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in Italy called for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers, uninfected patients, and the community. In our country, in a short time span, the demand for ... |
Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families | Domestic cats are commonly affected by viral pathogens that induce lengthy infections with fatal outcomes. Prevention of viral propagation is of primordial importance in shelters and catteries, where cats from different backgrounds have narrow contacts. Oligonucleotides (ODN) containing cytosine-phosphate-guanosine mot... |
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen | As with many other viruses, the initial cell attachment of rotaviruses, major causative agent of infantile gastroenteritis, is mediated by interactions with specific cellular glycans(1–4). The distally located VP8* domain of the rotavirus spike protein VP4(5) mediates such interactions. The existing paradigm is that ‘s... |
Analysis of Spatiotemporal Characteristics of Pandemic SARS Spread in Mainland China | Severe acute respiratory syndrome (SARS) is one of the most severe emerging infectious diseases of the 21st century so far. SARS caused a pandemic that spread throughout mainland China for 7 months, infecting 5318 persons in 194 administrative regions. Using detailed mainland China epidemiological data, we study spatio... |
High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation | OBJECTIVE: The Covid‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America, where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented. METHODS: In this retrospective cohort study we analyzed th... |
Infectious Disease Outbreak Response: Mind the Rights Gap | The international organization responsible for international coordinated response to disease outbreaks—the World Health Organization (WHO)—was given permission to receive reports from sources other than the state in revisions to the International Health Regulations (IHR) in 2005. However, the organization struggles to ... |
Hendra virus infection in a veterinarian | A veterinarian became infected with Hendra virus (HeV) after managing a terminally ill horse and performing a limited autopsy with inadequate precautions. Although she was initially only mildly ill, serological tests suggested latent HeV infection. Nevertheless, she remains well 2 years after her initial illness. Recen... |
Epidemiological and Virological Characteristics of Influenza Viruses Circulating in Cambodia from 2009 to 2011 | BACKGROUND: The Cambodian National Influenza Center (NIC) monitored and characterized circulating influenza strains from 2009 to 2011. METHODOLOGY/PRINCIPAL FINDINGS: Sentinel and study sites collected nasopharyngeal specimens for diagnostic detection, virus isolation, antigenic characterization, sequencing and antivir... |
Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates | A novel series of ribonucleosides of 1,2,3‐triazolylbenzyl‐aminophosphonates was synthesized through the Kabachnik–Fields reaction using I(2) as catalyst followed by copper‐catalyzed cycloaddition of the azide–alkyne reaction (CuAAC). All structures of the newly prepared compounds were characterized by (1)H NMR, (13)C ... |
An approach to and web-based tool for infectious disease outbreak intervention analysis | Infectious diseases are a leading cause of death globally. Decisions surrounding how to control an infectious disease outbreak currently rely on a subjective process involving surveillance and expert opinion. However, there are many situations where neither may be available. Modeling can fill gaps in the decision makin... |
Acral edema during the COVID‐19 pandemic | |
Ultrasensitive label-free electrochemiluminescence immunosensor based on N-(4-aminobutyl)-N-ethylisoluminol-functionalized graphene composite | The electrochemiluminescence (ECL) behavior of N-(4-aminobutyl)-N-ethylisoluminol (ABEI)-functionalized graphene composite (ABEI-GC) modified on an indium tin oxide (ITO) electrode was studied. ABEI-GC exhibited excellent ECL activity. On this basis, a label-free ECL immunosensor was developed for the sensitive detecti... |
Chapter 15 Application of Microbial Cleaning Technology for Removal of Surface Contamination | Abstract Microbial cleaning takes advantage of naturally-occurring microbes to remove a wide variety of contaminants from various surfaces. The method is based on the affinity of microbes for hydrocarbons that are digested, producing harmless carbon dioxide, water, and soluble fatty acids. The microbes are nonpathogeni... |
Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion | BACKGROUND: Donor lymphocyte infusion (DLI) is used for treatment of hematologic malignancy relapse or mixed chimerism after allogeneic hematopoietic stem cell transplantation. Although graft‐versus‐host disease is well recognized as one of the adverse effects of DLI, there are limited reports on noninfectious pulmonar... |
Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections | Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack of seroconversion among some PCR-confirmed cases has been reported.... |
Why lockdown of the elderly is not ageist and why levelling down equality is wrong | In order to prevent the rapid spread of COVID-19, governments have placed significant restrictions on liberty, including preventing all non-essential travel. These restrictions were justified on the basis the health system may be overwhelmed by COVID-19 cases and in order to prevent deaths. Governments are now consider... |
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