title stringlengths 0 221 | text stringlengths 0 375k |
|---|---|
L’après Covid-19: vers une dermatologie nouvelle? | |
AEP: Engine of the specialist's recognition and guarantor of the paediatric model. Generating health also in pandemic situations() | |
Effects of 1,2,4,6-tetra-O-galloyl-β-D-glucose from P. emblica on HBsAg and HBeAg secretion in HepG2.2.15 cell culture | A polyphenolic compound, 1,2,4,6-tetra-O-galloyl-β-D-glucose (1246TGG), was isolated from the traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae) and assayed for its potential as an anti-hepatitis B virus (HBV) agent. The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells was determined by obs... |
Structural analysis of the putative SARS-CoV-2 primase complex | We report the crystal structure of the SARS-CoV-2 putative primase composed of the nsp7 and nsp8 proteins. We observed a dimer of dimers (2:2 nsp7-nsp8) in the crystallographic asymmetric unit. The structure revealed a fold with a helical core of the heterotetramer formed by both nsp7 and nsp8 that is flanked with two ... |
Impact of COVID-19 outbreak measures of lockdown on the Italian Carbon Footprint | Abstract Stringent lockdown measures implemented in Italy to mitigate the spread of COVID-19 are generating unprecedented economic impacts. However, the environmental consequences associated with the temporary shutdown and recovery of industrial and commercial activities are still not fully understood. Using the well-k... |
DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial | BACKGROUND: DNA vaccine immunogenicity has been limited by inefficient delivery. Needle-free delivery of DNA using a CO(2)-powered Biojector® device was compared to delivery by needle and syringe and evaluated for safety and immunogenicity. METHODS: Forty adults, 18–50 years, were randomly assigned to intramuscular (IM... |
Editorial: COVID-19 and what it means for end-of-life care in ICU: Balancing the priorities | |
A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2 | Abstract The exact residues within severe acute respiratory syndrome coronavirus (SARS-CoV) S1 protein and its receptor, human ACE2, involved in their interaction still remain largely undetermined. Identification of exact amino acid residues that are crucial for the interaction of S1 with ACE2 could provide working hyp... |
Respiratory viral coinfection among hospitalized patients with H1N1 2009 during the first pandemic wave in Brazil | Abstract Influenza A coinfections with other respiratory viruses were investigated in 25.8% (41/159) of the samples from patients hospitalized in 2009 at our University Hospital. Out of the 41 influenza A cases, nine cases (21.9%) were coinfected with other viruses, with a similar frequency among children and adults (p... |
Biocatalytic properties of a novel crude glycyrrhizin hydrolase from the liver of the domestic duck | A novel crude glycyrrhizin (GL) hydrolase preparation from the liver of domestic duck was used to produce glycyrrhetic acid monoglucuronide. To characterize the biocatalytic profiles of the crude enzyme, some effect factors were investigated. It had an apparent optimal pH of 6.0 and an optimal temperature at 55 °C. Mos... |
Explosion in mortality in the Amazonian epicenter of the COVID-19 epidemic 19 | Manaus, the capital of the Brazilian State of Amazonas, is the current epicenter of the COVID-19 epidemic in Amazonia The sharp increase in deaths is a huge concern for health system administrators and society The study aimed to analyze excess overall mortality according to Epidemiological Week (EW) in order to identif... |
Establishment of a COVID‐19 Recovery Unit in a Veteran Affairs (VA) Post‐Acute Facility | Coronavirus disease 19 (COVID‐19) is now an epidemic of global proportion with major adverse impacts on older adults, persons with chronic diseases, and especially residents of long‐term care facilities. This health catastrophe has challenged healthcare facilities’ capacity to deliver care to not only COVID‐19 patients... |
Concurrent detection of other respiratory viruses in children shedding viable human respiratory syncytial virus | Human respiratory syncytial virus (HRSV) is an important cause of respiratory disease. The majority of studies addressing the importance of virus co‐infections to the HRSV‐disease have been based on the detection of HRSV by RT‐PCR, which may not distinguish current replication from prolonged shedding of remnant RNA fro... |
SARS‐CoV‐2 coinfections: Could influenza and the common cold be beneficial? | The novel coronavirus SARS‐CoV‐2 has rapidly spread around the world, causing serious illness and death and creating a heavy burden on the health care systems of many countries. Since the virus first emerged in late November 2019, its spread has coincided with peak circulation of several seasonal respiratory viruses, y... |
A simple and effective protective shield for the ophthalmoscope to prevent COVID‐19 | |
Bat and virus | Bat, the only flying mammal and count more than 20% of the extant mammals on earth, were recently identified as a natural reservoir of emerging and reemerging infectious pathogens. Astonishing amount (more than 70) and genetic diversity of viruses isolated from the bat have been identified in different populations thro... |
A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide | Hundreds of million people worldwide have been infected with severe acute respiratory syndrome (SARS), and the rate of global death from SARS has remarkably increased. Hence, the development of efficient drug treatments for the biological effects of SARS is highly needed. We have previously shown that quantum dots (QDs... |
Glutamyl Endopeptidases: The Puzzle of Substrate Specificity | Glutamyl endopeptidases (GEPases) are chymotrypsin-like enzymes that preferentially cleave the peptide bonds of the α-carboxyl groups of glutamic acid. Despite the many years of research, the structural determinants underlying the strong substrate specificity of GEPases still remain unclear. In this review, data concer... |
Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT(1) receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis | Recent studies have established a new regulatory axis in the renin–angiotensin system (RAS). In this axis, angiotensin (Ang)-(1–7) is finally produced from Ang I or Ang II by the catalytic activity of angiotensin-converting enzyme 2 (ACE2). Ang-(1–7) shows actions different from those of AT(1) receptor stimulation, suc... |
Characteristics and Injury Patterns in Electric-Scooter Related Accidents—A Prospective Two-Center Report from Germany | Since the introduction of rental E-scooters in Germany in mid-June 2019, the safety of this new means of transport has been the subject of extensive public debate. However, valid data on injuries and usage habits are not yet available. This retrospective two-center study included a total of 76 patients who presented to... |
Surveillance of Infectious Diseases | Surveillance is the ongoing, systematic collection, analysis, and interpretation of data essential to public health practice for public health action, closely integrated with the timely dissemination of these data to those who need to know. Modern surveillance systems must meet the challenges of a dynamic emergence of ... |
Selection of reference genes for gene expression analysis by real-time qPCR in avian cells infected with infectious bronchitis virus. | Infectious bronchitis virus (IBV) causes infectious bronchitis in poultry, a respiratory disease that is a source of major economic loss to the poultry industry. Detection and the study of the molecular pathogenesis of the virus often involve the use of real-time quantitative PCR assays (qPCR). To account for error wit... |
“Does having diabetes increase chances of contracting COVID-19 infection?” | |
Common Respiratory Tract Infections as Psychological Entities: A Review of the Mood and Performance Effects of Being Ill | The clinical manifestations associated with colds and influenza overshadow the equally important mood and performance impairments. While decreased alertness and increased anxiety can be considered side effects of symptomatology, symptoms alone may not be responsible for the psychomotor and attention deficits of colds a... |
Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? | Respiratory viruses infect the human upper respiratory tract, mostly causing mild diseases. However, in vulnerable populations, such as newborns, infants, the elderly and immune-compromised individuals, these opportunistic pathogens can also affect the lower respiratory tract, causing a more severe disease (e.g., pneum... |
Covid-19: Major US medical organisations urge people to wear masks. | |
Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus | Feline infectious peritonitis (FIP), caused by a mutated feline coronavirus, is one of the most serious and fatal viral diseases in cats. The disease remains incurable, and there is no effective vaccine available. In light of the pathogenic mechanism of feline coronavirus that relies on endosomal acidification for cyto... |
Selected TLR7/8 agonist and type I interferon (IFN-α) cooperatively redefine the microglia transcriptome | BACKGROUND: Microglia, the primary immune cells of the central nervous system, exerts multiple functions to mediate many neurological diseases. Upon any detection of invading pathogen products (e.g., TLR agonists) or host-released signaling factors (e.g., interferon/IFN), these cells undergo an activation process to re... |
Single particle assay of coronavirus membrane fusion with proteinaceous receptor-embedded supported bilayers | Abstract Total internal reflection microscopy combined with microfluidics and supported bilayers is a powerful, single particle tracking (SPT) platform for host-pathogen membrane fusion studies. But one major inadequacy of this platform has been capturing the complexity of the cell membrane, including membrane proteins... |
Responding to the Pandemic of Falsified Medicines | Over the past decade, the number of countries reporting falsified (fake, spurious/falsely labeled/counterfeit) medicines and the types and quantities of fraudulent drugs being distributed have increased greatly. The obstacles in combating falsified pharmaceuticals include 1) lack of consensus on definitions, 2) paucity... |
Developing vaccines against epidemic-prone emerging infectious diseases | Today’s world is characterized by increasing population density, human mobility, urbanization, and climate and ecological change. This global dynamic has various effects, including the increased appearance of emerging infectious diseases (EIDs), which pose a growing threat to global health security. Outbreaks of EIDs, ... |
Evaluation of the synergetic effect of Yupingfeng san and Flos Sophorae Immaturus based on free radical scavenging capacity | OBJECTIVE: This study aimed to determine the optimal extraction process and examine whether the combination ofFlos Sophorae Immaturus (FSI) and Yupingfeng san (YPS) has a synergistic effect on free radical scavenging capacity. DESIGN AND METHODS: The time of immersion and extraction and the ratios (material/solvent) of... |
Regulation of Stress Responses and Translational Control by Coronavirus | Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechani... |
A proposed treatment for pathogenic enveloped viruses having high rates of mutation or replication | Several enveloped viruses, particularly some RNA viruses, have high rates of mutation or replication, which can make them virulent pathogens in humans and other mammals. A proposed treatment could use synthesized proteins to mask pathogenic viral surface proteins to quickly induce an immune attack on specific enveloped... |
Stepwise prediction and statistical screening: B-cell epitopes on neuraminidase of human avian H(5)N(1) virus | The B-cell epitopes of virus are associated with the antiviral drug and the vaccine screening. As the nucleotide sequences of neuraminidase (NA) of stain GD-01-06 were sequenced, we predicted the α-helix and β-fold structure and the indexes of the flexible regions of secondary structure of NA with methods of the Hydrop... |
The Structure of a Rigorously Conserved RNA Element within the SARS Virus Genome | We have solved the three-dimensional crystal structure of the stem-loop II motif (s2m) RNA element of the SARS virus genome to 2.7-Å resolution. SARS and related coronaviruses and astroviruses all possess a motif at the 3′ end of their RNA genomes, called the s2m, whose pathogenic importance is inferred from its rigoro... |
The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis | Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a... |
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus | Passive serotherapy can confer immediate protection against microbial infection, but methods to rapidly generate human neutralizing monoclonal antibodies are not yet available. We have developed an improved method for Epstein-Barr virus transformation of human B cells. We used this method to analyze the memory repertoi... |
Visualizing the invisible: class excursions to ignite children’s enthusiasm for microbes | We have recently argued that, because microbes have pervasive – often vital – influences on our lives, and that therefore their roles must be taken into account in many of the decisions we face, society must become microbiology‐literate, through the introduction of relevant microbiology topics in school curricula (Timm... |
Blood-Borne Pathogens: A Canadian Blood Services Centre for Innovation Symposium | Abstract Testing donations for pathogens and deferring selected blood donors have reduced the risk of transmission of known pathogens by transfusion to extremely low levels in most developed countries. Protecting the blood supply from emerging infectious threats remains a serious concern in the transfusion medicine com... |
Chapter 27 Practical Considerations in Virtual Screening and Molecular Docking | Abstract Molecular docking has become an important common component of the drug discovery toolbox, and its relative low-cost implications and perceived simplicity of use has stimulated an everincreasing popularity within academic communities. The inherent “garbage-in-garbage-out” defect of molecular docking, however, l... |
Reflecting upon vulnerable and dependent bodies during the COVID‐19 crisis | This paper is a short narrative on how feminism helped me find a balance in my life and how this balance has been disrupted with the Covid‐19 crisis. I reflect on how this crisis is showing our vulnerabilities as human beings. This crisis reflects how our bodies depend on each other, moving away from the dominant patri... |
Porcine epidemic diarrhea: a review of current epidemiology and available vaccines | Porcine epidemic diarrhea virus (PEDV), an Alphacoronavirus in the family Coronaviridae, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. PEDV can also cause diarrhea, agalactia, and abnormal reproductive cycles in pregnant sows. Although PEDV was first identified in Europe, i... |
It’s True Even in a Pandemic: Children are Not Merely Little Adults | |
Estimation of the Probability of Reinfection With COVID-19 by the Susceptible-Exposed-Infectious-Removed-Undetectable-Susceptible Model | BACKGROUND: With the sensitivity of the polymerase chain reaction test used to detect the presence of the virus in the human host, the worldwide health community has been able to record a large number of the recovered population. OBJECTIVE: The aim of this study was to evaluate the probability of reinfection in the rec... |
Effect of lockdown amid COVID-19 pandemic on air quality of the megacity Delhi, India | Abstract Amid the COVID-19 pandemic, a nationwide lockdown is imposed in India initially for three weeks from 24th March to 14th April 2020 and extended up to 3rd May 2020. Due to the forced restrictions, pollution level in cities across the country drastically slowed down just within few days which magnetize discussio... |
Negotiating Inequality: Disruption and COVID‐19 in the United States | |
Chapter 14 The use of host factors in microbial forensics | Abstract Advances have been made in the forensic analysis of microbes and toxins. An underdeveloped and underutilized area in microbial forensics is how the host interacts with microorganisms in a way that provides unique signatures for forensic use. For forensic purposes, an immediate goal is to distinguish a potentia... |
Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine: a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial | BACKGROUND: Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection continue to rise in the Arabian Peninsula 7 years after it was first described in Saudi Arabia. MERS-CoV poses a significant risk to public health security because of an absence of currently available effective countermeasures. We ai... |
Questions raised by COVID‐19 case descriptions | |
Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis | Graphene-based materials are intriguing nanomaterials with applications ranging from nanotechnology-related devices to drug delivery systems and biosensing. Multifunctional graphene platforms were proposed for the detection of several typical biomarkers (i.e., circulating tumor cells, exosomes, circulating nucleic acid... |
Chapter 11 Systems Virology Why everybody wants to measure everything | Abstract Virologists have long known that viral pathogenesis must be studied from the standpoint of both the virus and the host. Nevertheless, given its relative simplicity, studying the virus has always been more tractable. As outlined in the previous chapters, virus-centric approaches have yielded a tremendous amount... |
The Sexual and Reproductive Health of Adolescents and Young Adults During the COVID‐19 Pandemic | |
A Case Report of a Middle East Respiratory Syndrome Survivor with Kidney Biopsy Results | A 68-year old man diagnosed with Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) presented with multiple pneumonic infiltrations on his chest X-ray, and the patient was placed on a mechanical ventilator because of progressive respiratory failure. Urinary protein excretion steadily increased for a microalbumin t... |
Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens | The devastating Ebola virus (EBOV) outbreak in West Africa in 2013–2016 has flagged the need for the timely development of vaccines for high-threat pathogens. To be better prepared for new epidemics, the WHO has compiled a list of priority pathogens that are likely to cause future outbreaks and for which R&D efforts ar... |
An original design of remote robot-assisted intubation system | The success rate of pre-hospital endotracheal intubation (ETI) by paramedics is lower than physicians. We aimed to establish a remote robot-assisted intubation system (RRAIS) and expected it to improve success rate of pre-hospital ETI. To test the robot’s feasibility, 20 pigs were intubated by direct laryngoscope or th... |
Computational Sequence Analysis of Mammalian Reovirus Proteins | In the present study, computer-assisted searches for sequence similarities were performed with amino acid sequences from mammalian reovirus proteins. These analysis revealed that many proteins of reovirus are partially similar to known viral or cellular proteins. Consensus sequences have been identified that are in acc... |
Analytic solution of the SEIR epidemic model via asymptotic approximant | An analytic solution is obtained to the SEIR Epidemic Model. The solution is created by constructing a single second-order nonlinear differential equation in [Formula: see text] and analytically continuing its divergent power series solution such that it matches the correct long-time exponential damping of the epidemic... |
Planning for a pandemic: Mitigating risk to radiation therapy service delivery in the COVID‐19 era | The novel coronavirus (COVID‐19) has rapidly impacted all of our lives following its escalation to pandemic status on 11 March 2020. Government guidelines and restrictions implemented to mitigate the risk of COVID‐19 community transmission have forced radiation therapy departments to promptly adjust to the significant ... |
Partial RdRp sequences offer a robust method for Coronavirus subgenus classification | The recent reclassification of the Riboviria, and the introduction of multiple new taxonomic categories including both subfamilies and subgenera for coronaviruses (family Coronaviridae, subfamily Orthocoronavirinae) represents a major shift in how official classifications are used to designate specific viral lineages. ... |
Status presens of antiviral drugs and strategies: Part II: RNA VIRUSES (EXCEPT RETROVIRUSES) | More than 40 compounds have been formally licensed for clinical use as antiviral drugs, and half of these are used for the treatment of HIV infections. The others have been approved for the therapy of herpesvirus (HSV, VZV, CMV), hepadnavirus (HBV), hepacivirus (HCV) and myxovirus (influenza, RSV) infections. New compo... |
How the coronavirus pandemic has affected the clinical management of Philadelphia-negative chronic myeloproliferative neoplasms in Italy—a GIMEMA MPN WP survey | |
RadioGraphics Update: Radiographic and CT Features of Viral Pneumonia | Editor’s Note.—Articles in the RadioGraphics Update section provide current knowledge to supplement or update information found in full-length articles previously published in RadioGraphics. Authors of the previously published article provide a brief synopsis that emphasizes important new information such as technologi... |
Concealed SARS-CoV-2 interstitial pneumonia unmasked by infarct-like acute myocarditis | |
Surveillance of respiratory viruses in the outpatient setting in rural coastal Kenya: baseline epidemiological observations | Background: Endemic and seasonally recurring respiratory viruses are a major cause of disease and death globally. The burden is particularly severe in developing countries. Improved understanding of the source of infection, pathways of spread and persistence in communities would be of benefit in devising intervention s... |
Ready or Not, Patients Will Present: Improving Urban Pandemic Preparedness | Over the past century, society has achieved great gains in medicine, public health, and health-care infrastructure, particularly in the areas of vaccines, antibiotics, sanitation, intensive care and medical technology. Still, despite these developments, infectious diseases are emerging at unprecedented rates around the... |
Medical and microbiological problems arising from airborne infection in hospitals | Abstract The practical importance and frequency of airborne nosocomial infections has been a matter of dispute for many years. This is because most of the pathogens acquired in hospitals are able to use various different routes of infecting the patient's body so that it may be difficult or even impossible to prove an i... |
15 Cleaning and decontamination of the healthcare environment | Abstract: Evidence is accumulating for the role of cleaning in controlling hospital infections. Hospital pathogens such as meticillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), norovirus, multi-resistant Gram-negative bacilli and Clostridium difficile persist in the healthcare envir... |
Chemo-enzymatic synthesis of C-9 acetylated sialosides | Abstract A chemo-enzymatic synthesis of [(5-acetamido-9-O-acetyl-3,5-dideoxy-d-glycero-α-d-galacto-2-nonulopyranosylonic acid)-(2→3)-O-(β-d-galactopyranosyl)-(1→3)-O-(2-acetamido-2-deoxy-α-d-galactopyranosyl)]-l-serine acetate (1) has been accomplished by a regioselective chemical acetylation of Neu5Ac (2) to give 9-O-... |
Chapter 9 Nutraceuticals in Alternative and Underutilized Fruits as Functional Food Ingredients: Ancient Species for New Health Needs | Abstract A diet containing high levels of fruit has been associated with a lowered risk of chronic diseases as, in addition to their vitamin and mineral content, they also contain various compounds with health-protective effects, in particular antioxidant and antiinflammatory compounds. Wild plant species are of intere... |
Atypical skin manifestations during immune checkpoint blockage in COVID19-infected lung cancer patients | Abstract A new coronavirus, named SARS-CoV-2 by the World Health Organization (WHO), has rapidly spread around the world since its first reported case in late December of 2019 from Wuhan, China. As of mid-April 2020, this virus has affected more than 180 countries and territories, infecting more than 1,650,000 individu... |
Considerations for Management of Longitudinal Melanonychia During the COVID-19 Pandemic: An International Perspective | |
Strategies for the prevention and management of coronavirus disease 2019 | Early protection, early identification, early diagnosis, and early isolation are crucial to combat with Covid-19 outbreaks |
Multiplex semi-nested RT-PCR with exogenous internal control for simultaneous detection of bovine coronavirus and group A rotavirus | Abstract Neonatal calf diarrhea is a multi-etiology syndrome of cattle and direct detection of the two major agents of the syndrome, group A rotavirus and Bovine coronavirus (BCoV) is hampered by their fastidious growth in cell culture. This study aimed at developing a multiplex semi-nested RT-PCR for simultaneous dete... |
The rubella virus E2 and E1 spike glycoproteins are targeted to the Golgi complex | Rubella virus (RV) has been reported to bud from intracellular membranes in certain cell types. In this study the intracellular site of targeting of RV envelope E2 and E1 glycoproteins has been investigated in three different cell types (CHO, BHK-21 and Vero cells) transfected with a cDNA encoding the two glycoproteins... |
Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes | The inaugural workshop “Deep Sequencing in Infectious Diseases: Immune and Pathogen Repertoires for the Improvement of Patient Outcomes” was held in Singapore on 13–14 October 2016. The aim of the workshop was to discuss the latest trends in using high-throughput sequencing, bioinformatics, and allied technologies to a... |
Comparison of Different Tests to Diagnose Feline Infectious Peritonitis | Clinical data from 488 cats (1979–2000) with histopathologically confirmed feline infectious peritonitis (FIP) and 620 comparable controls were evaluated retrospectively to assess the value of several diagnostic tests frequently used in the evaluation of cats with suspected FIP. Diagnostic utility of serum albumin to g... |
Sometimes Sperm Whales (Physeter macrocephalus) Cannot Find Their Way Back to the High Seas: A Multidisciplinary Study on a Mass Stranding | BACKGROUND: Mass strandings of sperm whales (Physeter macrocephalus) remain peculiar and rather unexplained events, which rarely occur in the Mediterranean Sea. Solar cycles and related changes in the geomagnetic field, variations in water temperature and weather conditions, coast geographical features and human activi... |
Resident viruses and their interactions with the immune system | The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human ‘virobiota’ and its associated genes (the ‘virome’), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we ex... |
An inflammatory cytokine signature helps predict COVID-19 severity and death | The COVID-19 pandemic caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to more than 100,000 deaths in the United States. Several studies have revealed that the hyper-inflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patien... |
Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens | Probiotics are live micro‐organisms with beneficial effects on human health, which have the ability to counteract infections at different locations of the body. Clinical trials have shown that probiotics can be used as preventive and therapeutic agents in upper respiratory tract infections (URTIs) and otitis. Their mec... |
Effect of COVID-19 Epidemic on Delay of Diagnosis and Treatment Path for Patients with Nasopharyngeal Carcinoma | INTRODUCTION: 2019 novel coronavirus disease (COVID-19) outbreaks have been occurring in China and other countries in the world. To prevent further spread of the disease, restrictions of population flow from the government and measures to reduce virus transmission from hospitals may lead to the delay of diagnosis and t... |
The effects of governmental and individual predictors on COVID‐19 protective behaviors in China: a path analysis model | The outbreak of the COVID‐19 pandemic has plunged the world into a crisis. To contain the crisis, it is essential to build full cooperation between the government and the public. However, it is unclear which governmental and individual factors are the determinants and how they interact on protective behaviors against C... |
Managing thromboembolic risk with menopausal hormone therapy and hormonal contraception in the COVID-19 pandemic: Recommendations from the Spanish Menopause Society, Sociedad Española de Ginecología y Obstetricia and Sociedad Española de Trombosis y Hemostasia | Abstract COVID-19 is associated with a systemic inflammatory response with activation of coagulation in symptomatic patients. The possibility of coagulopathies in peri- and postmenopausal women taking estrogen therapies makes it necessary to consider antithrombotic strategies, such as the use of low molecular weight he... |
Plasma medicine: Opportunities for nanotechnology in a digital age | Advances in digital technologies have opened new opportunities for creating more reliable, time‐ and cost‐effective, safer and mobile methods of diagnosing, managing and treating diseases. A few examples of advanced nano‐ and digital technologies are already FDA‐approved for diagnosing and treating diseases. Plasma tre... |
Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions | The key to better understanding complex virus-host interactions is the utilization of robust three-dimensional (3D) human cell cultures that effectively recapitulate native tissue architecture and model the microenvironment. A lack of physiologically-relevant animal models for many viruses has limited the elucidation o... |
Contact Tracing to Manage COVID19 Spread – Balancing Personal Privacy and Public Health | |
Health seeking behaviors of patients with acute respiratory infections during the outbreak of novel coronavirus disease 2019 in Wuhan, China | We conducted two surveys to evaluate the health-seeking behaviors of individuals with acute respiratory infections (ARI) during the COVID-19 outbreak in Wuhan, China. Among 351 participants reporting ARI (10.3%, 351/3,411), 36.5% sought medical assistance. Children were more likely to seek medical assistance than other... |
Could influenza transmission be reduced by restricting mass gatherings? Towards an evidence-based policy framework | Abstract Introduction Mass gatherings (MG) may provide ideal conditions for influenza transmission. The evidence for an association between MG and influenza transmission is reviewed to assess whether restricting MG may reduce transmission. Methods Major databases were searched (Pubmed, EMBASE, Scopus, CINAHL), producin... |
The genetic code as expressed through relationships between mRNA structure and protein function | Structured RNA elements within messenger RNA often direct or modulate the cellular production of active proteins. As reviewed here, RNA structures have been discovered that govern nearly every step in protein production: mRNA production and stability; translation initiation, elongation, and termination; protein folding... |
Life Trajectories, Biomedical Evidence, and Lessons for Policies | Here I compare two types of evidence that have recently emerged from the literature. This Commentary is a contribution to the Frontiers Research Topic on social disparities in aging, and aims to draw attention to the novel connections that link social disparities, the biological capital of individuals, and policy strat... |
A digital embrace to blunt the curve of COVID19 pandemic | Digital health, virtual care, telehealth, and telemedicine are all terms often used interchangeably to refer to the practice of care delivered from a distance. Because virtual care collapses the barriers of time and distance, it is ideal for providing care that is patient-centered, lower cost, more convenient and at gr... |
Institutional Preparedness to Prevent Future Middle East Respiratory Syndrome Coronavirus-Like Outbreaks in Republic of Korea | A year has passed since the Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea. This 2015 outbreak led to a better understanding of healthcare infection control. The first Korean patient infected by Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was diagnosed on May 20, 2015, after he re... |
Illicit drug use and harms in Australia in the context of COVID‐19 and associated restrictions: Anticipated consequences and initial responses | |
Cardiac Surgery and the COVID-19 Pandemic: What We Know, What We Don’t Know, and What We Need to Do | |
Interhospital Transfer of Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2: Preliminary Considerations From the Emilia-Romagna Experience | |
Reply to “Liver tests abnormalities in COVID-19: trick or treat?” | |
Igniting Change: Supporting the Well-Being of Academicians Who Practice and Teach Critical Care | Academicians who maintain a critical care clinical practice encounter numerous stressors, especially during the COVID-19 pandemic, which can influence well-being. This article provides historical perspectives on the stressors inherent in working in the critical care environment as well as the stressors of working in th... |
Review of Health Systems of the Middle East and North Africa Region | This article is an updated version of the previous edition article by Francisca Ayodeji Akala, volume 4, pp. 542–553, © 2008, Elsevier Inc. |
Chikungunya resurgence in the Maldives and risk for importation via tourists to Europe in 2019–2020: A GeoSentinel case series | BACKGROUND: Chikungunya virus (CHIKV) is an arthropod-borne virus mainly transmitted in tropical areas by Aedes spp. mosquitoes. It has been responsible for small-to-large outbreaks in temperate areas including southern Europe and North America. Past outbreaks in 2006 on the islands of Maldives, as well as on other isl... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.