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Utility of flexible bronchoscopy with polymerase chain reaction in the diagnosis and management of pulmonary infiltrates in allogeneic HSCT patients | OBJECTIVES: Pulmonary infiltrates in allogeneic hematopoietic stem cell transplant (allo‐HSCT) patients are potentially life‐threatening and require early diagnosis and treatment. We aimed to retrospectively explore the clinical efficacy of polymerase chain reaction (PCR) in conjunction with flexible bronchoscopy (FB) ... |
pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin | We previously reported the expression of soluble A/Victoria/3/75 (H3N2) hemagglutinin in insect cells and the molecular and immunological structure of an aggregated fraction, only observed in cell supernatant when expression was performed at low pH [23]. Here we report that besides this aggregated a monomeric and possi... |
Clinical trials for the prevention and treatment of COVID‐19: current state of play | Since coronavirus disease 2019 (COVID‐19) emerged in Wuhan, China in December 2019 and spread around the world, over 1100 clinical studies have been registered globally on clinical trials registries, including over 500 randomised controlled trials. Such rapid development and launch of clinical trials is impressive but ... |
Enfermement carcéral, confinement socio-sanitaire et moyens d’évasion.Danser sa peine et au-delà… | Abstract Jail incarceration and social confinement due to a sanitary stay-at-home law against the ongoing covid-19 pandemic are compared through the introduction of dance workshops for imprisoned women charged with long sentences, then followed by an outside performance Soul Kitchen. The whole experience, organized by ... |
Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes | Human cathepsin W (CtsW) is a cysteine protease, which was identified in a genome-wide RNA interference (RNAi) screen to be required for influenza A virus (IAV) replication. In this study, we show that reducing the levels of expression of CtsW reduces viral titers for different subtypes of IAV, and we map the target st... |
Nitric oxide inhibits the replication cycle of porcine parvovirus in vitro | This study investigated the inhibitory effect and mechanism of nitric oxide (NO) on porcine parvovirus (PPV) replication in PK-15 cells. The results showed that two NO-generating compounds, S-nitroso-l-acetylpenicillamine (SNAP) and l-arginine (LA), at a noncytotoxic concentration could reduce PPV replication in a dose... |
Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses | Abstract Severe Acute Respiratory Syndrome (SARS) is a respiratory disease caused by a zoonotic coronavirus (CoV) named SARS-CoV (SCoV), which rapidly swept the globe after its emergence in rural China during late 2002. The origins of SCoV have been mysterious and controversial, until the recent discovery of SARS-like ... |
Zoonoses: Infectious Diseases Transmissible From Animals to Humans, Fourth Edition | |
Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes | Many host cellular signaling pathways were activated and exploited by virus infection for more efficient replication. The PI3K/Akt pathway has recently attracted considerable interest due to its role in regulating virus replication. This study demonstrated for the first time that the mammalian reovirus strains Masked P... |
Preparation for and organization during a major incident | Major incidents during the past 30 years have caused the NHS and other agencies to respond in a coordinated fashion and create the comprehensive Emergency Preparedness, Resilience and Response framework 2013. This along with supporting documents gives a detailed structure of the role of the NHS in any type of major inc... |
Extension Horses, Inc. experts act fast to create online resources to assist the horse industry during COVID-19 | The COVID-19 pandemic and resulting stay-at-home directives, adopted out of necessity to protect human health, introduced significant challenges for horse owners and small equine businesses. Restricted access, and in many cases closure of barns, resulted in a multitude of questions and concerns within the equine commun... |
Respiratory Picornaviruses and Respiratory Syncytial Virus as Causative Agents of Acute Expiratory Wheezing in Children | We studied the viral etiology of acute expiratory wheezing (bronchiolitis, acute asthma) in 293 hospitalized children in a 2-year prospective study in Finland. A potential causative viral agent was detected in 88% of the cases. Eleven different viruses were represented. Respiratory syncytial virus (RSV) (27%), enterovi... |
Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance | Aging poses an increased risk of severe infection by respiratory syncytial virus (RSV). The many different biological pathways comprising the response to infection in lungs that are influenced by aging are complex and remain to be defined more thoroughly. Towards finding new directions in research on aging, we aimed to... |
Responding to Emerging Diseases Requires Multi-disciplinary and One Health Training, Egypt | BACKGROUND: In Egypt, several infectious diseases of zoonotic origin have emerged in recent years like H1N1, MERSCoV and H5N1, the latter now endemic. Responding to these diseases requires a workforce trained in multi-disciplinary approaches to zoonotic disease research and control. It is difficult to deliver multidisc... |
A Transgenic Flock House Virus Replicon Reveals an RNAi Independent Antiviral Mechanism Acting in Drosophila Follicular Somatic Cells | The small interfering RNA (siRNA) pathway is the main and best studied invertebrate antiviral response. Other poorly characterized protein based antiviral mechanisms also contribute to the control of viral replication in insects. In addition, it remains unclear whether tissue specific factors contribute to RNA and prot... |
COVID (Co-Operative Vascular Intervention Disease) Team of Greater Philadelphia | We established the COVID (Co-OperativeVascularInterventionDisease) Team of Greater Philadelphia because national guidelines may not apply to different geographic areas of the United States due to varying penetrance of the virus. On April 10, 2020, a ten-question survey regarding issues and strategies dealing with COVID... |
Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent | Research efforts of the ongoing SARS-CoV-2 pandemic have focused on viral genome sequence analysis to understand how the virus spread across the globe. Here, we assess three recently identified SARS-CoV-2 genomes in Beijing from June 2020 and attempt to determine the origin of these genomes, made available in the GISAI... |
Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition | Schistosomiasis is a major human parasitic disease with a global impact. Schistosoma japonicum, the most difficult to control, can survive within host veins for decades. Mechanisms of immune evasion by the parasite, including antigenic variation and surface masking, have been implicated but not well defined. In this st... |
Smell and taste alterations in Covid‐19: a cross‐sectional analysis of different cohorts | BACKGROUND: : Olfactory (OD) and gustatory (GD) dysfunction have been proven to be a typical symptom of SARS‐CoV‐2 infection. However, their prevalence in different patient populations still needs to be clarified. METHODS: : A cross‐sectional study was performed from March 27 to April 1 2020 in Northern Italy. Physicia... |
Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study | BACKGROUND: Identification of effective treatments in severe cases of COVID-19 requiring mechanical ventilation represents an unmet medical need. Our aim was to determine whether the administration of adipose-tissue derived mesenchymal stromal cells (AT-MSC) is safe and potentially useful in these patients. METHODS: Th... |
Cystatin D, a natural salivary cysteine protease inhibitor, inhibits coronavirus replication at its physiologic concentration | This study was conducted to examine the effect of cystatin D, a newly discovered salivary cysteine protease inhibitor, on human coronavirus replication. When MRC‐5, human diploid lung cells, were incubated with dilutions of recombinant human cystatin D from 0.65–10 μM for 1 h prior to, during and after infection with c... |
Chapter 21 Gnotobiotics and the Microbiome | Abstract This chapter provides an overview of germfree (GF), gnotobiotic (GN), and defined flora (DF) laboratory rats, relating their history, traditional and modern derivation procedures, the anatomy and physiology, and their use in the study of mammalian host–microbiome relationships. Extensive literature on the nutr... |
COVID and CopMich: comparing and contrasting COVID-19 experiences in the USA and Scandinavia | On 11 March 2020, the World Health Organization declared SARS-CoV-2 and its associated disease, COVID-19, a global pandemic. Across the world, governments took action to slow the spread and hospitals rushed to accommodate an influx of patients with this highly infectious and lethal disease. The urology departments in A... |
Detection of Clostridium perfringens alpha toxin gene in lambs by loop mediated isothermal amplification | AIM: The loop mediated isothermal amplification (LAMP) was standardized for rapid detection of Clostridium perfringens. MATERIALS AND METHODS: A total of 120 fecal samples were collected from enterotoxemia suspected lambs were used for screening of C. perfringens cpa gene by LAMP. The specificity of the LAMP amplified ... |
Aligning Student‐Led Initiatives and Incident Command System Resources in a Pandemic | Removed from classrooms and clinics amid the COVID‐19 pandemic, health professions students have answered the call to serve alternate roles by rapidly mobilizing to address health system and community‐identified needs in innovative ways. Many institutions, including the University of Nebraska Medical Center (UNMC), hav... |
A nation-wide epidemiological study of acute bovine respiratory disease in France | Abstract Acute bovine respiratory disease (ABRD) is a respiratory syndrome caused by various infectious agents, and represents a major economic and health problem in cattle herds worldwide. The aim of the study was to present how we can describe the epidemiological characteristics of ABRD in France, including risk fact... |
The epidemiological characteristics of 2019 novel coronavirus diseases (COVID-19) in Jingmen, Hubei, China | There is currently a global outbreak of coronavirus disease 2019 (COVID-19), and its epidemic characteristics in the areas where the outbreak has been successfully controlled are rarely reported. Describe the epidemic characteristics of COVID-19 in Jingmen, Hubei, introduce the local prevention and control experience, ... |
How to deal with COVID-19 epidemic-related lockdown physical inactivity and sedentary increase in youth? Adaptation of Anses’ benchmarks | Faced with the spread of the SARS-CoV-2 virus, regulatory measures aiming to prevent interpersonal contaminations have been undertaken and among these, lockdown. Due to strong restrictions out-of-home movements, we hypothesize that overall physical activity will decrease and sedentary behavior increase. This could resu... |
Is there a Role for Cyclophilin Inhibitors in the Management of Primary Biliary Cirrhosis? | Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly understood autoimmune liver diseases. Immunosuppression is used to treat AIH and ursodeoxycholic acid is used to slow the progression of PBC. Nevertheless, a proportion of patients with both disorders progress to liver failure. Following liver tr... |
New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection | |
COVID‐19: Face masks and human‐to‐human transmission | In December 2019, transmission of the novel coronavirus (SARS-CoV-2) that causes coronavirus disease 2019(COVID-19) occurred in Wuhan, China1 .And later the virus began to be transmitted from person to person2 .Face masks are a type of personal protective equipment used to prevent the spread of respiratory infections，i... |
GeneOne Life Science | |
Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers | BACKGROUND: We retrospectively analysed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. METHODS: Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 RNA testing were obtained. RESULTS: Twenty-two patients... |
XI SOLANEP International Congress / XV Cystic Fibrosis Latinamerican Congress / XV Brazilian Congress of Pediatric Pulmonology | |
Experiences from the 2014 outbreak of bluetongue in Greece | Abstract Objective of this paper was to review relevant work and to present a general account of the bluetongue outbreak, which occurred in Greece in 2014. In total, 2895 outbreaks of the disease have been reported by the veterinary authorities of Greece; sheep, goats and cattle were affected with officially reported m... |
Two X‐linked agammaglobulinemia patients develop pneumonia as COVID‐19 manifestation but recover | BACKGROUND: The recent SARS‐CoV‐2 pandemic, which has recently affected Italy since February 21, constitutes a threat to normal subjects, as the coronavirus disease‐19 (COVID‐19) can manifest with a broad spectrum of clinical phenotypes ranging from asymptomatic cases to pneumonia or even death. There is evidence that ... |
Influenza vaccination in patients with asthma: effect on peak expiratory flow, asthma symptoms and use of medication | Abstract This pilot study was undertaken to examine whether killed influenza vaccine causes exacerbations in asthmatic adults. Thirty-three stable asthmatics recorded peak expiratory flow (PEF), asthma symptoms, and use of asthma medication for 2 weeks, and then received killed influenza vaccine. Thereafter they record... |
A DEDICATED PATH TO EMERGENT THORACIC SURGERY IN COVID-19 PATIENTS: AN ITALIAN INSTITUTION PROTOCOL | Abstract The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic pointed out that the need to ensure emergent surgery in positive for infection patients is no longer hypothetical. Among emergency procedures, thoracic surgical operations are frequent. A standardized surgical pathway is mand... |
Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015–2016: a hospital-based test-negative case–control study in Lithuania | OBJECTIVE: A case–control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015–2016 influenza season. METHODS: A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vac... |
Pandemic Influenza and Hospital Resources | Using estimates from the Centers for Disease Control and Prevention, the World Health Organization, and published models of the expected evolution of pandemic influenza, we modeled the surge capacity of healthcare facility and intensive care unit (ICU) requirements over time in northern Netherlands (≈1.7 million popula... |
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol | Abstract Cholesterol 25-hydroxylase (CH25H) has been shown lately to be a host restriction factor that encodes an enzyme, which catalyzes the oxidized form of cholesterol to 25-hydroxycholesterol (25HC). A series of studies have shown that 25HC activity in hosts plays a vital role in inhibiting viral infection. In this... |
Development of duplex real-time PCR for detection of two DNA respiratory viruses | Abstract A method was developed for the detection and quantitation of HAdV (human adenovirus) and HBoV (human bocavirus) based on a duplex real-time PCR, the AB PCR, using a Smartcycler instrument. A control real-time PCR was carried out on albumin DNA to standardise the non-homogenous respiratory samples. No cross-rea... |
Acute phase response to Mycoplasma haemofelis and ‘Candidatus Mycoplasma haemominutum’ infection in FIV-infected and non-FIV-infected cats | The pathogenicity of Haemoplasma spp. in cats varies with ‘Candidatus Mycoplasma haemominutum’ (CMhm) causing subclinical infection while Mycoplasma haemofelis (Mhf) often induces haemolytic anaemia. The aims of this study were to characterise the acute phase response (APR) of the cat to experimental infection with Mhf... |
8 Sanitary and environmental aspects of sewage sludge management | Abstract Currently, sewage sludge management is a huge challenge in the field of environmental engineering. New effective solutions for the treatment of wastewater led to an improvement of the quality of the final effluent but considerably increased the volume of produced sewage sludge, which increases each year. Two p... |
Clinical Characteristics of Asthmatic Patients With Influenza-Like Illness and Risk for Severe Exacerbations in Mexico | Abstract Background Patients with chronic inflammatory lung diseases, such as asthma, are at higher risk for influenza-like illness (ILI) complications. Viral infections are known to trigger asthma exacerbations, but a thorough description of the clinical characteristics of ILI-associated asthma exacerbations and the r... |
Les effets épigénétiques du cannabis / tétrahydrocannabinol | Résumé La diffusion, sur un mode quasi pandémique, du cannabis chez les adolescents et adultes jeunes, spécialement en France, justifie l’attention portée aux conséquences, non seulement aiguës, mais également différées de cette intoxication. Dans cette dernière éventualité interviennent des mécanismes épigénétiques. O... |
A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS‐CoV) in a Hospital Setting Through Bioaerosols | Middle Eastern respiratory syndrome, an emerging viral infection with a global case fatality rate of 35.5%, caused major outbreaks first in 2012 and 2015, though new cases are continuously reported around the world. Transmission is believed to mainly occur in healthcare settings through aerosolized particles. This stud... |
Assessing restoration benefit of grassland ecosystem incorporating preference heterogeneity empirical data from Inner Mongolia Autonomous Region | The evaluation of grassland ecosystem restoration benefit considering herdsmen's preference is an important reference for the formulation of grassland protection policy. This study aims to evaluate the marginal benefits of grassland ecosystem services by using choice experiment and mixed logit (ML) model, and a latent ... |
The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses | Although effective antibody-based vaccines have been developed against multiple viruses, such approaches have so far failed for the human immunodeficiency virus type 1 (HIV-1). Despite the success of anti-retroviral therapy (ART) that has turned HIV-1 infection into a chronic disease and has reduced the number of new i... |
Evolution and variation of 2019-novel coronavirus | Background The current outbreak caused by novel coronavirus (2019-nCoV) in China has become a worldwide concern. As of 28 January 2020, there were 4631 confirmed cases and 106 deaths, and 11 countries or regions were affected. Methods We downloaded the genomes of 2019-nCoVs and similar isolates from the Global Initiati... |
Dynamic changes of serum SARS-Coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge | OBJECTIVE: The intent of this study was to examine the recovery of individuals who had been hospitalized for severe acute respiratory syndrome (SARS) in the year following their discharge from the hospital. Parameters studied included serum levels of SARS coronavirus (SARS-CoV) IgG antibody, tests of lung function, and... |
Détection pré et postopératoire de l’infection virale en cas de chirurgie carcinologique ne pouvant être retardée, pendant la pandémie de COVID-19 | |
Predicting contaminant dispersion using modified turbulent Schmidt numbers from different vortex structures | Abstract Air pollutant transmission has significant influences on indoor air quality (IAQ). It is crucial to study mechanisms involved with airborne contaminant dispersion indoors. However, relationship between pollutant diffusion coefficient and viscosity in enclosed spaces has not been fully understood. In this study... |
Diagnosis of human coronavirus infection by immunofluorescence: Method and application to respiratory disease in hospitalized children | Rabbit antisera were prepared against coronavirus strains 229E and OC43 and used successfully to detect viral antigen in epithelial cells shed from the nasopharynx of symptomatic volunteers who had received coronavirus inocula three to four days before. The same serologic reagents were applied to nasopharyngeal secreti... |
Chapter 10 Emerging viral infections | Abstract The emergence of viral infections is driven by multiple factors including changes in human behavior, population growth, reservoir host distribution, viral diversity and environmental changes. Effective surveillance methods, diagnostic assays and containment measures are pivotal to preventing widespread outbrea... |
Comment on “Psoriasis, COVID‐19 and acute respiratory distress syndrome: focusing on the risk of concomitant biological treatment” | |
COVID‐19– Are telehealth and tele‐education the answers to keep the ball rolling in Dentistry? | Larry David, the co-creator and producer of Seinfeld, when asked by a reporter from the New York Times about what he fears the most while quarantining during the COVID 19 Epidemic, responded "Anarchy and a potential dental emergency - and not necessarily in that order"(Dowd, 2020).The pandemic introduced a new layer of... |
A One Health Perspective on the Human–Companion Animal Relationship with Emphasis on Zoonotic Aspects | Over time the human–animal bond has been changed. For instance, the role of pets has changed from work animals (protecting houses, catching mice) to animals with a social function, giving companionship. Pets can be important for the physical and mental health of their owners but may also transmit zoonotic infections. T... |
Rhinovirus frequently detected in elderly adults attending an emergency department | The general aim was to investigate the burden of respiratory virus illness in a hospital emergency department, during two different epidemic seasons. Consecutive patients attending an emergency department during two study periods (February/March 2009 and 2010) were enrolled using broad inclusion criteria (fever/precedi... |
Quantification of the severity of an outbreak in human infection control | Summary Background The severity of an outbreak is a priority in decision-making for human infection control. However, there have been no reports on how to quantify the severity of an outbreak. Methods We propose a simple method to measure the severity of an infectious disease outbreak. It involves scoring the severity ... |
High-titer preparation of Bombyx mori nucleopolyhedrovirus (BmNPV) displaying recombinant protein in silkworm larvae by size exclusion chromatography and its characterization | BACKGROUND: Budded baculoviruses are utilized for vaccine, the production of antibody and functional analysis of transmembrane proteins. In this study, we tried to produce and purify the recombinant Bombyx mori nucleopolyhedrovirus (rBmNPV-hPRR) that displayed human (pro)renin receptor (hPRR) connected with FLAG peptid... |
Bayesian modelling of an epidemic of severe acute respiratory syndrome | This paper analyses data arising from a SARS epidemic in Shanxi province of China involving a total of 354 people infected with SARS-CoV between late February and late May 2003. Using Bayesian inference, we have estimated critical epidemiological determinants. The estimated mean incubation period was 5.3 days (95% CI 4... |
Using Grounded Theory to Inform the Human-Centered Design of Digital Health in Geriatric Palliative Care | CONTEXT: Digital health offers innovative mechanisms to engage in palliative care, yet digital systems are typically designed for individual users, rather than integrating the patient’s caregiving “social convoy” (i.e. family members, friends, neighbors, formal caregiving supports) to maximize benefit. As older adults ... |
The molecular structure of 4-methylpyridine-N-oxide: Gas-phase electron diffraction and quantum chemical calculations | Abstract The molecular structure of 4-methylpiridine-N-oxide, 4-MePyO, has been studied by gas-phase electron diffraction monitored by mass spectrometry (GED/MS) and quantum chemical (DFT) calculations. Both, quantum chemistry and GED analyses resulted in C S molecular symmetry with the planar pyridine ring. Obtained m... |
Sequencing B cell receptors from ferrets (Mustela putorius furo) | The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunological insights are restricted due to a lack of ferret-specific reagents and limited genetic information about ferret B and T cell receptors. Here, variable, diversity and joining genes withi... |
Rapid review protocol: zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections | Abstract Background . The global COVID-19 pandemic has prompted an urgent search for effective interventions. SARS-CoV-2 mortality/morbidity risk increases with age and for those chronic disease co-morbidities, both of which are associated with lower zinc status, as is the risk of infection. Methods Rapid review method... |
Risks of Death and Severe Disease in Patients With Middle East Respiratory Syndrome Coronavirus, 2012–2015 | Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen, first recognized in 2012, with a high case fatality risk, no vaccine, and no treatment beyond supportive care. We estimated the relative risks of death and severe disease among MERS-CoV patients in the Middle East between 2012 and 2015 for... |
The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species | The HIV-1 accessory protein Vpu enhances virus release by counteracting the host restriction factor tetherin. To further understand the role of host cell proteins in Vpu function, we carried out yeast two-hybrid screening and identified a previously reported Vpu-interacting host factor, small glutamine-rich tetratricop... |
Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness | RATIONALE: Medical masks are commonly used by sick individuals with influenza-like illness (ILI) to prevent spread of infections to others, but clinical efficacy data are absent. OBJECTIVE: Determine whether medical mask use by sick individuals with ILI protects well contacts from related respiratory infections. SETTIN... |
Magnetic Beads‐Based Electrochemical Sensors Applied to the Detection and Quantification of Bioterrorism/Biohazard Agents | Nowadays, detecting the presence of bioterrorism and biohazard agents in environmental and food samples is of great concern, due to their toxicity, and because many of them are prone to be used in terrorism attacks. The use of functionalized magnetic beads (MBs) in the development of electrochemical immuno‐ and genosen... |
Bioinformatics studies on a function of the SARS-CoV-2 spike glycoprotein as the binding of host sialic acid glycans | SARS-CoV and SARS-CoV-2 do not appear to have functions of a hemagglutinin and neuraminidase. This is a mystery, because sugar binding activities appear essential to many other viruses including influenza and even most other coronaviruses in order to bind to and escape from the glycans (sugars, oligosaccharides or poly... |
Practical Guide for Pediatric Pulmonologists on Imaging Management of Pediatric Patients with COVID‐19 | Understanding of coronavirus disease 2019 is rapidly evolving with new articles on the subject daily. This flood of articles can be overwhelming for busy practicing clinicians looking for key pieces of information that can be applied in daily practice. This review article synthesizes the reported imaging findings in pe... |
Discovery of novel astrovirus and calicivirus identified in ruddy turnstones in Brazil | Birds are the natural reservoir of viruses with zoonotic potential, as well as contributing to the evolution, emergence, and dissemination of novel viruses. In this study, we applied a high-throughput screening approach to identify the diversity of viruses in 118 samples of birds captured between October 2006 to Octobe... |
The COVID-19 & Cancer Consortium (CCC19): a collaborative effort to understand the effects of COVID-19 on patients with cancer | Summary National and international consortia will play a key role in understanding the effects of the coronavirus disease 2019 (COVID-19) pandemic on cancer patients. The COVID-19 & Cancer Consortium (CCC19) aims to collect and analyze observational data at scale to inform clinical practice in real-time. |
Impact of reduction in contact time activity of infected individuals on the dynamics and control of directly transmitted respiratory infections in SIR models | This paper aims to study the impact of using an educational strategy on reducing the efforts needed to control respiratory transmitted infections represented by SIR models, taking into account heterogeneity in contacts between infected and non-infected individuals. Therefore, a new incidence function, in which the diff... |
Milk-derived antimicrobial peptides to protect against Neonatal Diarrheal Disease: An alternative to antibiotics | Abstract Neonatal Diarrheal Disease is responsible for significant economic losses to the livestock industries in Canada and around the world. Microbes responsible are diverse and include Escherichia coli, Salmonella, Rotavirus, Coronavirus and Cryptosporidia. While the use of antibiotics as a treatment for bacterial i... |
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS‐CoV) and its putative receptor, angiotensin‐converting enzyme 2 (ACE2) | Severe acute respiratory syndrome (SARS) is an emerging infectious disease associated with a new coronavirus, SARS‐CoV. Pulmonary involvement is the dominant clinical feature but extra‐pulmonary manifestations are also common. Factors that account for the wide spectrum of organ system involvement and disease severity a... |
5 An Analysis of Demographic and Behavior Trends Using Social Media: Facebook, Twitter, and Instagram | Abstract Personality and character have major effects on certain behavioral outcomes. As advancements in technology occur, more people these days are using social media such as Facebook, Twitter, and Instagram. Due to the increase in social media's popularity, the types of behaviors are now easier to group and study as... |
Protest tegen protest | DENVER, VS - Deze verpleegkundige probeert samen met collega-zorgverleners demonstrerende automobilisten tegen te houden. De demonstranten togen eind april naar de regeringsgebouwen in Denver, Colorado, omdat ze het niet eens waren met de lockdown die de staat had opgelegd. Fotograaf Alyson McClaran vertelt dat deze ve... |
Daycaritis | Healthy infants and toddlers who attend day care centers are at increased risk for contracting common childhood illnesses such as viral upper and lower respiratory illnesses, viral gastrointestinal infections, and acute and chronic otitis media. The author proposes that this high frequency of common infections be terme... |
Responding to COVID‐19: How to Navigate a Public Health Emergency Legally and Ethically | Few novel or emerging infectious diseases have posed such vital ethical challenges so quickly and dramatically as the novel coronavirus SARS‐CoV‐2. The World Health Organization declared a public health emergency of international concern and recently classified COVID‐19 as a worldwide pandemic. As of this writing, the ... |
Membrane and Phospholipid Binding by Murine Coronaviral Nucleocapsid N Protein | Abstract Evidence is presented which indicates that membrane binding of the murine coronavirus, mouse hepatitis virus (MHV) nucleocapsid (N) protein is mediated by certain lipids. Binding of N protein to membranes of mouse fibroblast L-2 cells is very specific and occurs under conditions in which no other viral or cell... |
Epidemiological, clinical and genotypic features of human Metapneumovirus in patients with influenza-like illness in Senegal, 2012 to 2016 | BACKGROUND: Human metapneumovirus (HMPV) is a causal agent of acute respiratory infection, especially in primarily children. At the clinical level, HMPV is associated to several diseases including bronchitis, croup, pneumonia, bronchiolitis, reactive airway disease, chronic obstructive pulmonary disease and asthma exac... |
Priming with SARS CoV S DNA and boosting with SARS CoV S epitopes specific for CD4(+) and CD8(+) T cells promote cellular immune responses | Cellular immune response plays an important role in antiviral immunity. In our previous study, immunization of mice with severe acute respiratory syndrome coronavirus (SARS CoV) spike (S) DNA vaccine could induce both humoral and cellular immunity in response to a pool of entire overlapping S peptides. Identification o... |
WHO informal consultation on the guidelines for evaluation of the quality, safety, and efficacy of DNA vaccines, Geneva, Switzerland, December 2019 | Consultations have been held to promote the revision of the WHO guidelines for assuring the quality and nonclinical safety evaluation of DNA vaccines adopted by the Expert Committee on Biological Standardization (ECBS) in 2005. The drivers for this revision are described, including the need for regulatory convergence h... |
The role of a Coronavirus disease 2019 pharmacist: an Australian perspective | The coronavirus disease 2019 (COVID-19) pandemic has greatly impacted healthcare services around the world. Pharmacists are front-line healthcare professionals and integral members of the healthcare team. The deployment of a specialized ‘COVID pharmacist’ within our institution has demonstrated that the skills of the p... |
Employing dermatologists on the frontline against COVID‐19: All hands on deck | |
Accommodation of large cargo within Golgi cisternae | In mammalian cells, the Golgi complex has an elaborate structure consisting of stacked, flattened cisternal membranes collected into a ribbon in the center of the cell. Amazingly, the flattened cisternae can rapidly dilate to accommodate large cargo as it traffics through the organelle. The mechanism by which this occu... |
Mitigating mental health consequences during the COVID‐19 outbreak: Lessons from China | |
Community-acquired pneumonia: An overview | Community-acquired pneumonia is still a significant cause of morbidity and mortality and is often misdiagnosed and inappropriately treated. Although it can be caused by a wide variety of micro-organisms, the pneumococcus, atypicals, such as Mycoplasma pneumoniae and Chlamydophila pneumoniae, Staphylococcus aureus and c... |
Comparison of multiplexed-tandem real-time PCR panel with reference real-time PCR molecular diagnostic assays for detection of Giardia intestinalis and Tritrichomonas foetus in cats | Abstract Giardia intestinalis and Tritrichomonas foetus are frequent enteric protozoan parasites of the gastrointestinal track of domestic cats. Because of different treatment options for the parasites, confirmation of presence of one or both pathogens is necessary. The PCR based assays are suitable for differential di... |
Molecular epidemiology of influenza B virus among hospitalized pediatric patients in Northern Italy during the 2015-16 season | BACKGROUND: The influenza B viruses belong to two lineages distinguished by their genetic and antigenic characteristics, which are referred to as the Yamagata and Victoria lineages, designated after their original isolates, B/Yamagata/16/88 and B/Victoria/2/87. The primary aim of this study was to evaluate the molecula... |
Effect of Human Coronavirus OC43 Structural and Accessory Proteins on the Transcriptional Activation of Antiviral Response Elements | OBJECTIVES: The molecular mechanisms underlying the pathogenesis of human coronavirus OC43 (HCoV-OC43) infection are poorly understood. In this study, we investigated the ability of HCoV-OC43 to antagonize the transcriptional activation of antiviral response elements. METHODS: HCoV-OC43 structural (membrane M and nucle... |
Why not to use colchicine in COVID-19? An old anti-inflammatory drug for a novel auto-inflammatory disease | |
Transcriptional slippage occurs during elongation at runs of adenine or thymine in Escherichia coli. | A run of 11 adenine or thymine residues at the 5' end of an out-of-frame lacZ gene causes a high level of beta-galactosidase expression in E. coli. This effect was not observed for a run of guanine residues. Reverse transcription of mRNA isolated from E. coli containing the run of 11 A's reveals heterogeneity of transc... |
Fibrinolytic components in nasal mucosa and nasal secretion | We evaluated a possible role for fibrinolytic components in nasal secretion by tissue localization with immunohistochemical techniques and by measuring their antigen concentrations in nasal discharge by means of ELISA and fibrin autography. Nasal mucosa was obtained surgically from the inferior turbinate. Urokinase-typ... |
Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections | BACKGROUND: Molecular techniques can often reveal a broader range of pathogens in respiratory infections. We aim to investigate the prevalence and age pattern of viral co-infection in children hospitalized with lower tract acute respiratory infection (LT-ARI), using molecular techniques. METHODS: A nested polymerase ch... |
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors | Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to (Coronavirus) CoV epidemics. Neither vaccines nor therapeutics are ava... |
Letter to the Editor: Three cases of re‐detectable positive SARS‐CoV‐2 RNA in recovered COVID‐19 patients with antibodies | The number of hospitalized cases has declined significantly in Wuhan. However, there have been reports that several cases of re‐detectable positive SARS‐CoV‐2 RNA in recovered COVID‐19 patients, the potential reasons of re‐detectable positive patients remained elusive. Here, we report three confirmed cases of COVID‐19 ... |
COVID-19 Fear in Eastern Europe: Validation of the Fear of COVID-19 Scale | COVID-19 is a major source of fear, stress, and anxiety as well as a major factor impacting the health and wellbeing of people worldwide. The present study builds on the recently developed “Fear of COVID-19 Scale” (Ahorsu et al., In International Journal of Mental Health and Addiction, 10.1007/s11469-020-00270-8, 2020)... |
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