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Temporal and spatial evolution of online public sentiment on emergencies | Abstract The transmission of online emergency information has become an active means of expressing public opinion and has vitally affected societal emergency response techniques. This paper analyzes interactions between three groups in time and space using a classic SIR (susceptible, infected, and recovered) epidemic m... |
epicontacts: Handling, visualisation and analysis of epidemiological contacts | Epidemiological outbreak data is often captured in line list and contact format to facilitate contact tracing for outbreak control. epicontacts is an R package that provides a unique data structure for combining these data into a single object in order to facilitate more efficient visualisation and analysis. The packag... |
Impact of coronavirus outbreak on NO(2) pollution assessed using TROPOMI and OMI observations | Spaceborne NO(2) column observations from two high‐resolution instruments, TROPOMI onboard Sentinel‐5 Precursor and OMI on Aura, reveal unprecedented NO(2) decreases over China, South Korea, Western Europe and the U.S. as a result of public health measures enforced to contain the coronavirus disease outbreak (Covid‐19)... |
Robots, pipelines, polyproteins: Enabling multiprotein expression in prokaryotic and eukaryotic cells | Abstract Multiprotein complexes catalyze vital biological functions in the cell. A paramount objective of the SPINE2 project was to address the structural molecular biology of these multiprotein complexes, by enlisting and developing enabling technologies for their study. An emerging key prerequisite for studying compl... |
Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored | Abstract Objective To describe the clinical features of coronavirus disease 2019 (COVID-19). Methods We recruited 73 patients with COVID-19 [49 men and 24 women; average age: 58.36 years (SD: 14.31)] admitted to the intensive care unit of Wuhan Jinyintan Hospital from December 30, 2019 to February 16, 2020. Demographic... |
Digital Health Management During and Beyond the COVID-19 Pandemic: Opportunities, Barriers, and Recommendations | During the coronavirus disease (COVID-19) crisis, digital technologies have become a major route for accessing remote care. Therefore, the need to ensure that these tools are safe and effective has never been greater. We raise five calls to action to ensure the safety, availability, and long-term sustainability of thes... |
13 Ebola virus: where does it come from and where is it going? | Publisher Summary This chapter discusses the emergence and natural history of Ebola viruses. The fact that the Ebola virus subtypes, which have caused human disease episodes, have been different from one another makes it clear that a common source human-to-human transmission chain extending across sub-Saharan Africa is... |
Fibrinolysis Shutdown and Thrombosis in Severe SARS-CoV-2 (COVID-19) | |
Protocol for teledentistry during COVID-19 in Armed Forces dental establishments | |
Impact of drug price adjustments on utilization of and expenditures on angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in Taiwan | BACKGROUND: A previous study has suggested that drug price adjustments allow physicians in Taiwan to gain greater profit by prescribing generic drugs. To better understand the effect of price adjustments on physician choice, this study used renin-angiotensin drugs (including angiotensin-converting enzyme inhibitors [AC... |
Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity | Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. Here we identify the promyelocytic leukemia zinc finger (PLZF) protein as a previously unrecognized component of the IFN ... |
The Impact of Middle East Respiratory Syndrome Outbreak on Trends in Emergency Department Utilization Patterns | Changes occurred in the patterns of utilization of emergency medical services during the Middle East respiratory syndrome (MERS) outbreak. The purpose of this study was to analyze the patterns of adult and pediatric patients who visited the emergency department (ED) during the outbreak. This retrospective study was con... |
Systemic endothelial dysfunction: a common pathway for COVID-19, cardiovascular and metabolic diseases | Some of the mechanisms and conditions underlying endothelial dysfunction.A-human skin capillaries, visualized with high-resolution intravital color microscopy in the finger of a patient with obesity, metabolic syndrome and coronary artery disease.B- healthy control. The reduced number of capillaries can be noticed in A... |
Recombinase‐Based Isothermal Amplification of Nucleic Acids with Self‐Avoiding Molecular Recognition Systems (SAMRS) | Recombinase polymerase amplification (RPA) is an isothermal method to amplify nucleic acid sequences without the temperature cycling that classical PCR uses. Instead of using heat to denature the DNA duplex, RPA uses recombination enzymes to swap single‐stranded primers into the duplex DNA product; these are then exten... |
Identification of common and severe COVID-19: the value of CT texture analysis and correlation with clinical characteristics | OBJECTIVE: To explore the value of CT texture analysis (CTTA) for determining coronavirus disease 2019 (COVID-19) severity. METHODS: The clinical and CT data of 81 patients with COVID-19 were retrospectively analyzed. The texture features were extracted using LK2.1. The two-sample t test or Mann–Whitney U test was used... |
Cortex phellodendri Extract Relaxes Airway Smooth Muscle | Cortex phellodendri is used to reduce fever and remove dampness and toxin. Berberine is an active ingredient of C. phellodendri. Berberine from Argemone ochroleuca can relax airway smooth muscle (ASM); however, whether the nonberberine component of C. phellodendri has similar relaxant action was unclear. An n-butyl alc... |
Digital technology can revolutionize mental health services delivery: The COVID‐19 crisis as a catalyst for change | The unprecedented COVID‐19 crisis presents an imperative for mental health care systems to make digital mental health interventions a routine part of care. Already because of COVID‐19, many therapists have rapidly moved to using telehealth in place of in‐person contact. In response to this shift, Waller and colleagues ... |
SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways | The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression of the coronavirus receptor, ACE2, as well as the viral S protein priming protease TMPRSS2 thought to govern viral entry in single-cell RNA... |
Emerging and reemerging respiratory viral infections up to Covid-19 | Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA vir... |
First Things First: Parent Psychological Flexibility and Self-Compassion During COVID-19 | The COVID-19 pandemic has brought about significant stress and anxiety for many parents around the world. Psychological flexibility and self-care are fundamental aspects of psychological health. For parents, shaping these processes may help promote family nurturance, support children’s prosocial behavior, and provide e... |
Seasonal evaluation of bioaerosols from indoor air of residential apartments within the metropolitan area in South Korea | The aims of the present study were to determine the levels of bioaerosols including airborne culturable bacteria (total suspended bacteria, Gram-positive bacteria, Staphylococcus, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria), fungi, endotoxin, and viruses (influenza A, infl... |
Conferencia de Consenso sobre bronquiolitis aguda (II): epidemiología de la bronquiolitis aguda. Revisión de la evidencia científica | Resumen Presentamos una revisión de la evidencia sobre epidemiología, factores de riesgo, etiología y perfil clínico-etiológico de la bronquiolitis aguda. Las estimaciones de frecuencia son muy heterogéneas; para población menor de 2 años la frecuencia de ingreso por bronquiolitis se sitúa entre 1 y 3,5%, la de consult... |
A systematic review of neurological manifestations of SARS‐CoV‐2 infection: the devil is hidden in the details | BACKGROUND: We systematically reviewed available evidence for reports of neurological signs and symptoms in Coronavirus disease (COVID)‐19 patients to identify cases with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection or immune‐mediated reaction in the nervous system. METHODS: We followed PRISMA... |
Chloroquine and COVID-19: A Western Medical and Scientific Drift? | |
Potential changes to the hikikimori phenomenon in the wake of the Covid-19 pandemic | |
COVID-19 and surface water quality: Improved lake water quality during the lockdown | Abstract Human life comes to a standstill as many countries shut themselves off from the work due to the novel coronavirus disease pandemic (COVID-19) that hit the world severely in the first quarter of 2020. All types of industries, vehicle movement, and people's activity suddenly halted, perhaps for the first time in... |
COVID-19: The forgotten priorities of the pandemic | Abstract The zoonotic virus now named SARS-CoV-2 first infected humans in China, and COVID-19 has rapidly become pandemic. To mitigate its impact on societies, health systems and economies, countries have adopted non-pharmacological preventive practices such as ‘spatial’ or ‘social’ distancing, the use of protective ma... |
Persistent Seoul virus infection in Lewis rats | Mechanistic studies of hantavirus persistence in rodent reservoirs have been limited by the lack of a versatile animal model. This report describes findings from experimental infection of inbred Lewis rats with Seoul virus strain 80–39. Rats inoculated with virus intraperitoneally at 6 days of age became persistently i... |
Interferons at age 50: past, current and future impact on biomedicine | The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical effectiveness against both RNA and DNA viruses, but are also the prototypic biological response modifiers for oncology, and show effective... |
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host | Bats are special in their ability to host emerging viruses. As the only flying mammal, bats endure high metabolic rates yet exhibit elongated lifespans. It is currently unclear whether these unique features are interlinked. The important inflammasome sensor, NLR family pyrin domain containing 3 (NLRP3), has been linked... |
Community-based programs to tackle environmental education and COVID-19: A case study from Millburn, New Jersey | Contextual and social realities must be built into any educational program for activism to take place. This case study examines an education and environment program which has adapted to the social distancing measures of COVID-19, resulting in an even more community-reliant and community-driven program than the program ... |
A Deep Learning System to Screen Novel Coronavirus Disease 2019 Pneumonia | The real-time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab had a relatively low positive rate in the early stage of coronavirus disease 2019 (COVID-19). Meanwhile, the manifestations of COVID-19 as seen through computed tomography (CT) imaging show i... |
Vaccine Development for Nipah Virus Infection in Pigs | Nipah virus (NiV) causes a severe and often fatal neurological disease in humans. Whilst fruit bats are considered the natural reservoir, NiV also infects pigs and may cause an unapparent or mild disease. Direct pig-to-human transmission was responsible for the first and still most devastating NiV outbreaks in Malaysia... |
Microbiota and probiotics in canine and feline welfare | Abstract Dogs and cats have been cohabiting with us for thousands of years. They are the major human companions. Today, dogs and cats live in urban areas. Cats and most dogs are on high carbohydrate diets and face similar life-style challenges as the human beings. The health and well-being of companion animals, just as... |
An Opportunistic Pathogen Afforded Ample Opportunities: Middle East Respiratory Syndrome Coronavirus | The human coronaviruses (CoV) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, some of which have been known for decades. The severe acute respiratory syndrome (SARS) CoV briefly emerged into the human population but was controlled. In 2012, another novel severely human pathogenic CoV—the Middle East Respiratory... |
The COVID‐19 epidemic | The current outbreak of the novel coronavirus Covid-19 (coronavirus disease 2019; previously 2019-nCoV), epi-centered in Hubei Province of the People's Republic of China, has spread to many other countries. On January 30, 2020, the WHO Emergency Committee declared a global health emergency based on growing case notific... |
Development of a degenerated TaqMan real‐time Q‐PCR for detection of bacteria‐free DNA in dialysis fluid | Bacterial‐derived DNA fragments (BDNAs) have been shown to be present in a dialysis fluid, to pass through dialyzer membranes, and to induce interleukin 6 (IL‐6) in mononuclear cells. DNA fragments are thought to be derived from microorganisms inhabiting hemodialysis water and fluid. The primary aim of the present stud... |
DDESC: Dragon database for exploration of sodium channels in human | BACKGROUND: Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT s... |
Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing | The newly emergent human virus SARS-CoV-2 is resulting in high fatality rates and incapacitated health systems. Preventing further transmission is a priority. We analyzed key parameters of epidemic spread to estimate the contribution of different transmission routes and determine requirements for case isolation and con... |
COVID‐19: Nasal and oropharyngeal swab | Performing a proper nasal and oropharyngeal swab procedure is essential in the screening of COVID‐19 infection. The video illustration of nasal and oropharyngeal swab is presented (Video S1). To correctly perform the nasopharyngeal swab, the patient must be seated comfortably with the back of their head against the hea... |
A Survey Exploring Personalized Medicine among of Radiography Academics within the United Kingdom | INTRODUCTION: This article explores the application of personalized medicine (PM) within the academic environment in the United Kingdom. There is a growing acceptance of the utility of PM in health care and the role medical imaging can play. In response, this article explored the views and opinions of diagnostic and th... |
Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts | [Image: see text] A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed excellent aqueous solubility at pH 7.4 (61 mg/mL) compared to the natural product (17 μg/mL). The estimated shelf life (t(90)) for hydrolysis of the pr... |
Der erste COVID-19-Hotspot in einer Hamburger Senioreneinrichtung: Präventionskonzept, Letalität und Obduktionsbefunde | BACKGROUND: Coronavirus disease 2019 (COVID-19), a disease caused by the new coronavirus (SARS-CoV-2), is a particular threat to old people. At the end of March 2020, the first and so far largest outbreak of the disease occurred in a retirement home in Hamburg. METHODS: Analysis of procedures in dealing with a resident... |
Luminescence literature | |
The ProTide Prodrug Technology: From the Concept to the Clinic: Miniperspective | [Image: see text] The ProTide technology is a prodrug approach developed for the efficient intracellular delivery of nucleoside analogue monophosphates and monophosphonates. In this approach, the hydroxyls of the monophosphate or monophosphonate groups are masked by an aromatic group and an amino acid ester moiety, whi... |
A Taxonomy Proposal for the Assessment of the Changes in Soundscape Resulting from the COVID-19 Lockdown | Many countries around the world have chosen lockdown and restrictions on people’s mobility as the main strategies to combat the COVID-19 pandemic. These actions have significantly affected environmental noise and modified urban soundscapes, opening up an unprecedented opportunity for research in the field. In order to ... |
Recommendations from the CSO-HNS taskforce on performance of tracheotomy during the COVID-19 pandemic | INTRODUCTION: The performance of tracheotomy is a common procedural request by critical care departments to the surgical services of general surgery, thoracic surgery and otolaryngology - head & neck surgery. A Canadian Society of Otolaryngology – Head & Neck Surgery (CSO-HNS) task force was convened with multi-special... |
Rates of symptomatic SARS-CoV-2 infection in patients with autoimmune liver diseases in Northern Italy: a telemedicine study | |
Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists | In this article, we describe the design, synthesis and activity evaluation of glycomimetic DC-SIGN antagonists, that use a mannose residue to anchor to the protein carbohydrate recognition domain (CRD). The molecules were designed from the structure of the known pseudo-mannobioside antagonist 1, by including additional... |
Regulation of influenza virus replication by Wnt/β-catenin signaling | Wnt/β-catenin signaling is an essential pathway in cell cycle control. Dysregulation of the Wnt/β-catenin signaling pathway during viral infection has been reported. In this study, we examined the effect of modulating Wnt/β-catenin signaling during influenza virus infection. The activation of the Wnt/β-catenin pathway ... |
The “crisis after the crisis”: the time is now to prepare your radiology department | |
Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study | BACKGROUND: Host genetic factors are important determinants in tuberculosis (TB). The SLC11A1 (or NRAMP1) gene has been studied extensively for genetic association with TB, but with inconsistent findings. In addition, no study has yet looked into the effect of sex and age on the relationship between SLC11A1 polymorphis... |
In silico approach to screen compounds active against parasitic nematodes of major socio-economic importance | BACKGROUND: Infections due to parasitic nematodes are common causes of morbidity and fatality around the world especially in developing nations. At present however, there are only three major classes of drugs for treating human nematode infections. Additionally the scientific knowledge on the mechanism of action and th... |
Stewardship opportunities in viral pneumonia: Why not the immunocompromised? | Antimicrobial management of viral pneumonia has proven to be a challenge in hospitalized immunocompromised patients. A host of factors contribute to the dilemma, such as diagnostic uncertainty, lack of organism identification, and clinical status of the patient. Respiratory virus panel (RVP) use was compared between 13... |
Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities | [Image: see text] Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2 has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological agent of “coronavirus disease 2019”, abbreviated to COVID-19, which despite only being identified at the very end of 2019, h... |
Anxiety and public responses to covid-19: Early data from Thailand | Any new pandemic has the potential to arouse considerable anxiety, with this anxiety associated in previous work with economic disruption and societal disruption. We examined anxiety, symptom awareness, trust and associated behavioural responses in the first three weeks of the SARS-CoV-2 (covid-19) outbreak in Thailand... |
COVID-19, Ethics and Equity—What Is Our Role as Surgeons? | |
Standardization of enzyme-linked immunosorbent assays for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling | The extent of SARS-CoV-2 infection throughout the United States population is currently unknown. High quality serology is a key tool to understanding the spread of infection, immunity against the virus, and correlates of protection. Limited validation and testing of serology assays used for serosurveys can lead to unre... |
The first report of Hepatozoon canis infection of a dog in Iran | An 11-year-old male dog was presented with a 1-week history of inappetence, weight loss and hind limb paralysis. Physical examination revealed weakness, depression, incoordination of the posterior limbs, peripheral lymphadenopathy and pale mucous membranes. Laboratory analysis of blood samples revealed anaemia, thrombo... |
Evidence of a Novel Human Coronavirus That Is Associated with Respiratory Tract Disease in Infants and Young Children | Background. The etiological agents responsible for a substantial proportion of respiratory tract diseases have not been identified. We sought to determine whether novel human coronaviruses (HCoVs) are circulating in New Haven, Connecticut, and, if so, whether they are associated with respiratory tract disease in infant... |
Further Studies on Aminopeptidase-M in Blood in Children with Cholestatic Liver Diseases and Viral Hepatitis | Aim of this study was to determine and furthercharacterize the serum aminopeptidase-M in children withliver diseases. Based on our new assay, we have showntwo fractions of the enzyme. Activity of the first fraction is expressed in undiluted serumat pH adjusted from 8.5 (pH of storaged serum) to 7.4.Activity of the seco... |
Imaging and clinical features of patients with 2019 novel coronavirus SARS‐CoV‐2: A systematic review and meta‐analysis | BACKGROUND: Currently, the epidemic of coronavirus disease 2019 (COVID‐19) has begun to spread worldwide. We aim to explore reliable evidence for the diagnosis and treatment of the COVID‐19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia cau... |
Letter to the Editor: Are severe COVID‐19 patients more susceptible to conjunctivitis? | We read with interest the article by Lorenzo et al On Conjunctivitis and COVID-19: a meta analysis. We appreciate the article's suggestions on protection in ophthalmic diagnosis and treatment, but believe that the data and conclusions in meta-analysis need further study. This article is protected by copyright. All righ... |
Chapter 12. Antiviral Agents | Publisher Summary This chapter discusses the agents with activity primarily against RNA viruses. The communicable diseases of the respiratory tract are probably the most common cause of symptomatic human infections. The viruses that are causative agents for human respiratory disease comprise the five taxonomically dist... |
Elevated levels of plasma cytokines in COVID-19 reflect viral load and lung injury | This article was published early due to publisher error and has been temporarily removed. The publisher apologizes for the error. |
COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures | BACKGROUND: Cruise ships carry a large number of people in confined spaces with relative homogeneous mixing. On 3 February, 2020, an outbreak of COVID-19 on cruise ship Diamond Princess was reported with 10 initial cases, following an index case on board around 21-25(th) January. By 4(th) February, public health measur... |
Adipogenesis in ducks interfered by small interfering ribonucleic acids of peroxisome proliferator-activated receptor γ gene | ABSTRACT Peroxisome proliferator-activated receptor γ (PPARγ) participates in adipocyte differentiation and maintenance, including the promotion of lipid storage in mammals. In the present study, 3 duck PPARγ small interfering RNA (siRNA) expression plasmids were constructed to investigate the effect of downregulating ... |
Using Artificial Intelligence in Infection Prevention | PURPOSE OF REVIEW: Artificial intelligence (AI) offers huge potential in infection prevention and control (IPC). We explore its potential IPC benefits in epidemiology, laboratory infection diagnosis, and hand hygiene. RECENT FINDINGS: AI has the potential to detect transmission events during outbreaks or predict high-r... |
SARS-Cov-2 outbreak-imposed medical isolation increased sleep problems | |
IL‐1 blockade with anakinra in acute leukaemia patients with severe COVID‐19 pneumonia appears safe and may result in clinical improvement | As of 17th May, 2020 the number of patients infected by coronavirus disease 2019 (COVID‐19) worldwide has exceeded 4.5 million (WHO 2020). A subgroup of patients with COVID‐19 pneumonia develop a hyperinflammatory syndrome which has a similar cytokine release profile to secondary haemophagocytic lymphohistiocytosis (HL... |
Constructing and transient expression of a gene cassette containing edible vaccine elements and shigellosis, anthrax and cholera recombinant antigens in tomato | Shigella dysenteriae causing shigellosis is one of the diseases that threaten the health of human society in the developing countries. In Shigella, IpaD gene is one of the key pathogenic genes causing strong mucosal immune system reactions. Anthrax disease is caused by Bacillus anthracis. PA protective antigen is one o... |
Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site | An important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for druggin... |
Duty of care and health worker protections in the age of Ebola: lessons from Médecins Sans Frontières | |
Sequence analysis of the nucleoprotein genes of three enterotropic strains of murine coronavirus | The nucleotide sequences of the nucleoprotein genes of three enterotropic strains of the murine coronavirus mouse hepatitis virus (MHV-Y, MHV-RI and DVIM) were determined and compared with previously reported sequences of three polytropic (respiratory) strains (MHV-A59, MHV-JHM and MHV-S). Greater than 92% homology was... |
A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease | Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal with no approved vaccine available. In the present study, the attenuated poxvirus vector, Modified Vaccinia virus Ankara, was u... |
Community‐acquired respiratory viruses and co‐infection among patients of Ontario sentinel practices, April 2009 to February 2010 | Please cite this paper as: Peci et al. (2012) Community‐acquired respiratory viruses and co‐infection among patients of Ontario Sentinel practices, April 2009 to February 2010. Influenza and Other Respiratory Viruses 7(4), 559–566. Background Respiratory viruses are known to cocirculate but this has not been described ... |
Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm | BACKGROUND: Prematurity in itself and exposure to neonatal intensive care triggers inflammatory processes and oxidative stress, leading to risk for disease later in life. The effects on cellular aging processes are incompletely understood. METHODS: Relative telomere length (RTL) was measured by qPCR in this longitudina... |
Education as the path to a sustainable recovery from COVID-19 | COVID-19 has disrupted education for millions of children across the globe. The education community is re-imagining and re-designing to build back better. This Viewpoint takes the principles behind UNESCO’s Futures of Education initiative to highlight their importance in post-COVID-19 recovery. The pandemic has shown h... |
One Health concept for strengthening public health surveillance and response through Field Epidemiology and Laboratory Training in Ghana | The lack of highly trained field epidemiologists in the public health system in Ghana has been known since the 1970s when the Planning Unit was established in the Ghana Ministry of Health. When the Public Health School was started in 1994, the decision was taken to develop a 1 academic-year general MPH course. The pers... |
Knocking Out Angiotensin II in the Heart | Despite ongoing medical advances, cardiovascular disease continues to be a leading health concern. The renin-angiotensin system (RAS) plays an important role in regulating cardiovascular function, and is, therefore, the subject of extensive study. Several drugs currently used to treat hypertension and heart failure are... |
Middle East respiratory syndrome: pathogenesis and therapeutic developments | The first case of Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in the year 2012, which spread rapidly and increased to more than 2200 in 2018. This highly pathogenic virus with high mortality rate is among one of the major public health concerns. Saudi Arabia remains to be the most affected re... |
Gut Brain Axis and Its Microbiota Regulation in Mammals and Birds | This article provides a brief overview of the advances made in microbiota research in parrots and pet birds. It describes this complex ecosystem and the contribution of the intestinal microbiota to host health and disease, including the nervous system. |
Inpatient Dermatology Consultations during Covid 19 Pandemic in a Tertiary Referral Center | Since the COVID‐19 infection first appeared in December 2019, patient profile of outpatient and inpatient clinics have changed. Various cutaneous findings associated with COVID‐19 have been reported in the literature. The main objective of this study was to describe and analyze the profile of the consultations requeste... |
AKT1 polymorphisms are associated with tuberculosis in the Chinese population | AKT1, a serine/threonine kinase, plays a critical role in the controlling of intracellular growth of Mycobacterium tuberculosis. In this study, we investigated whether polymorphisms in AKT1 affect susceptibility to tuberculosis (TB). Two single nucleotide polymorphisms of AKT1, IVS3+18C>T and +726G>A were genotyped in ... |
Schistosomiasis control and the health system in P.R. China | Over the last sixty years advances have been made in the control of schistosomiasis in P.R. China. There are, however, difficult challenges still to be met. This paper looks at the extent to which the health system offers a positive environment for the control of the disease. It starts by tracing three phases in schist... |
Level of colorectal cancer awareness: a cross sectional exploratory study among multi-ethnic rural population in Malaysia | BACKGROUND: This paper presents the level of colorectal cancer awareness among multi-ethnic rural population in Malaysia. METHODS: A rural-based cross sectional survey was carried out in Perak state in Peninsular Malaysia in March 2011. The survey recruited a population-representative sample using multistage sampling. ... |
Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children | Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-c... |
Sign‐on letter requests more flexibility in methadone treatment during COVID‐19 | A sign‐on letter spearheaded by the National Alliance for Medication Assisted Recovery (NAMA), and harm reduction groups, including the Urban Survivors Union (USU) and the Drug Policy Alliance (DPA) is calling for reducing restrictions on methadone and opioid treatment programs (OTPs), so that patients don't have to go... |
A multiplex quantitative real-time polymerase chain reaction panel for detecting neurologic pathogens in dogs with meningoencephalitis | Meningoencephalitis (ME) is a common inflammatory disorder of the central nervous system in dogs. Clinically, ME has both infectious and non-infectious causes. In the present study, a multiplex quantitative real-time polymerase chain reaction (mqPCR) panel was optimized for the detection of eight canine neurologic path... |
Social Network Analysis for Coronavirus (COVID‐19) in the United States | OBJECTIVES: This study explores how public key players play an important role in social networks for coronavirus (COVID‐19). METHODS: This study employs social network analyses based on 2,864 Twitter users and 2,775 communications of Twitter. RESULTS: This study finds that President Trump plays the most important role ... |
SARS-Cov-2 infection: response of human immune system and possible implications for the rapid test and treatment | Abstract The new coronavirus outbreak is an ongoing pandemic that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The new coronavirus SARS-Cov-2 belongs to the subfamily of β−coronaviruses and shares 79.5% of the genetic sequence of SARS-CoV, the causative agent of the epidemic that started i... |
Henipavirus RNA in African Bats | BACKGROUND: Henipaviruses (Hendra and Nipah virus) are highly pathogenic members of the family Paramyxoviridae. Fruit-eating bats of the Pteropus genus have been suggested as their natural reservoir. Human Henipavirus infections have been reported in a region extending from Australia via Malaysia into Bangladesh, compa... |
Interferon-Independent Innate Responses to Cytomegalovirus | The critical role of interferons (IFNs) in mediating the innate immune response to cytomegalovirus (CMV) infection is well established. However, in recent years the functional importance of the IFN-independent antiviral response has become clearer. IFN-independent, IFN regulatory factor 3 (IRF3)-dependent interferon-st... |
Waiting for COVID‐19 | I wrote this as a narrative piece for school, but it is a very honest description of how I'm feeling at this time. I just wanted to reassure people that I am ok. For anyone else who is feeling the same as I am, it's ok. I think it is good for us to be honest about how we are feeling, and it is perfectly reasonable for ... |
Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study | BACKGROUND: Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS: A multicenter nested case-control study was conducted in fou... |
Influenza and Influenza-Like Viruses: Frequent Infections in Children Under 14 Years of Age During the 2016/2017 Epidemic Season | Influenza is an infectious disease that is a common cause of infection among children. The main reason for it is the extremely low percentage of vaccinated people in Poland. In the 2016/2017 epidemic season more than 3,000 tests from children up to age 14 were examined. The dominance of subtype A/H3N2/ (40.9%) was conf... |
Challenges of global surveillance during an influenza pandemic | Summary Surveillance is an essential foundation for monitoring and evaluating any disease process, and is especially critical when new disease agents appear. The H1N1 influenza pandemic of 2009 tested the capacities of countries to detect, assess, notify and report events as required by the 2005 International Health Re... |
A Low-cost Solution for Retrofitment of HEPA Filter in Healthcare Facilities Providing Care to COVID-19 Patients | |
Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2 | The COVID-19 global pandemic is caused by SARS-CoV-2, and represents an urgent medical and social issue. Unfortunately, there is still not a single proven effective drug available, and therefore, current therapeutic guidelines recommend supportive care including oxygen administration and treatment with antibiotics. Rec... |
Aspartate aminotransferase: a prognostic marker rather than a specific liver injury marker in COVID-19 |
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