title stringlengths 0 221 | text stringlengths 0 375k |
|---|---|
Impedimetric cell-based biosensor for real-time monitoring of cytopathic effects induced by dengue viruses | Abstract We describe an impedimetric cell-based biosensor constructed from poly-l-lysine (PLL)-modified screen-printed carbon electrode for real-time monitoring of dengue virus (DENV) infection of surface-immobilized baby hamster kidney (BHK-21) fibroblast cells. Cytopathic effects (CPE) induced by DENV-2 New Guinea C ... |
Quercetin, Inflammation and Immunity | In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet aggregation and capillary permeability. This review focuses on ... |
SEROEPIDEMIOLOGIC SURVEY OF CORONAVIRUS (STRAIN OC 43) RELATED INFECTIONS IN A CHILDREN'S POPULATION | Kaye, H. S. (CDC, Atlanta, Ga. 30333), H. B. Marsh and W. R. Dowdle. Sero-epidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Amer J Epid 94: 43–49, 1971.—Acute and convalescent serum pairs and control sera collected from subjects living in a children's home over a 7-year p... |
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection | Enhancing the response to interferon could offer an immunological advantage to the host. In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human ce... |
Determination of Ferret Enteric Coronavirus Genome in Laboratory Ferrets | Ferret enteric coronavirus (FRECV) RNA was detected in laboratory ferrets. Analysis of the complete genome sequence of 2 strains, FRCoV4370 and FRCoV063, revealed that FRECV shared 49.9%–68.9% nucleotide sequence identity with known coronaviruses. These results suggest that FRECV might be classified as a new species in... |
Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents | Abstract The tylophorine analog rac-cryptopleurine exhibited potent anti-hepatitis C virus (HCV) activity through allosteric regulation of ATPase activity of heat shock cognate protein 70 (Hsc70). We evaluated the impact of modifications on the E-ring of rac-cryptopleurine to the inhibitory activity against HCV replica... |
Heterogeneity of the L2 gene of field isolates of bluetongue virus serotype 17 from the San Joaquin Valley of California | Abstract Genome segment 2 (L2) from six field isolates of bluetongue virus (BTV) serotype 17 was sequenced by cycling sequencing after the amplification of the viral cDNA by the polymerase chain reaction. The viruses were isolated from sheep, cattle and a goat in the San Joaquin Valley of California during the years 19... |
What can we do for part‐time nursing students during the COVID‐19 pandemic? | In our Bachelor of Nursing programme (part-time), students are registered nurses working within various clinical and primary care settings. In light of the COVID-19 pandemic, all face-to-face teaching has been suspended since early February and our epidemiology course has moved entirely to online teaching. We needed to... |
Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department | As of March 30(th), 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise. Other than supportive care, there are no SARS-CoV-2 specific treatments available for patients discharged from the emergency department (ED) or those admitted to ... |
Evolving status of the 2019 novel coronavirus infection: Proposal of conventional serologic assays for disease diagnosis and infection monitoring | The novel coronavirus (nCoV-2019) outbreak in Wuhan, China has spread rapidly nationwide, with some cases occurring in other parts of the world. Although most patients present with mild febrile illness with patchy pulmonary inflammation, a significant portion develop severe acute respiratory distress syndrome (ARDS), w... |
Synthesis, characterization and biological activity of a niobium-substituted-heteropolytungstate on hepatitis B virus | Abstract To synthesise and characterize the polyoxometalate Cs2K4Na[SiW9Nb3O40]·H2O 1 for its anti-hepatitis B virus (HBV) properties by using the HepG2.2.15 cell. The methylthiazol tetrazolium assay was used to evaluate the growth inhibitory effect of Compound 1 on HepG2.2.15 cell. By using ELISA and real-time PCR, re... |
Severe Acute Respiratory Syndrome Beyond Amoy Gardens: Completing the Incomplete Legacy | The temporal and spatial distributions of the 2003 severe acute respiratory syndrome (SARS) outbreak in Amoy Gardens of Hong Kong was reexamined using all confirmed cases. The outbreak actually extended to nearby residential complexes. Airborne spread was the most likely explanation, and the SARS coronavirus could have... |
Thrombocytopenia is independently associated with poor outcome in patients hospitalized for COVID‐19 | Thrombocytopenia (defined by platelet count <150 x 10(9)/L) has been observed in up to 36% of patients with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for Coronavirus disease 2019 (COVID‐19; Guan et al, 2020). In this setting, thrombocytopenia is usually mild, caused by plat... |
SARS-CoV-2 Infection Leads to Neurological Dysfunction | A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demonstrate headache, nausea and vomiting, up to 40% present also experience dizziness, confusion, cerebrovascular ... |
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites | The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during t... |
Triaging Total Hip Arthroplasty During the COVID-19 Pandemic | PURPOSE OF REVIEW: The purpose of this review was to evaluate the available literature to determine what may be considered urgent indications for total hip arthroplasty, in the unprecedented setting of the worldwide COVID-19 pandemic. RECENT FINDINGS: SARS-CoV-2 is a novel coronavirus currently presenting in the form o... |
Natural antiviral compound silvestrol modulates human monocyte‐derived macrophages and dendritic cells | Outbreaks of infections with viruses like Sars‐CoV‐2, Ebola virus and Zika virus lead to major global health and economic problems because of limited treatment options. Therefore, new antiviral drug candidates are urgently needed. The promising new antiviral drug candidate silvestrol effectively inhibited replication o... |
Changing worlds of revenue management | Vinod sets out how the airline industries' cashflow has been effected by COVID-19 pandemic, setting out new rules for APTCo rule categories Whereas Oance discusses how airlines presently optimize fare structure based upon expertise and market awareness of its pricing professionals Whereas in the future, a new world of ... |
Index to volume 42, July–December 2003 | |
A missing link between SARS‐CoV‐2 and the eye?: ACE2 expression on the ocular surface | We applaud Lange et al.1 for their extensive efforts to analyse entry factors for severe acute respiratory syndrome coronavirus (SARS-CoV-2) into conjunctival epithelial cells covering the ocular surface, which is an important albeit controversially discussed issue1,2 . This article is protected by copyright. All right... |
Covid-19: Selected NHS patients will be treated with remdesivir | |
Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease | Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Di... |
Elevated transmission of upper respiratory illness among new recruits in military barracks in Thailand | BACKGROUND: New recruits within military barracks present conditions favorable for the spread of respiratory pathogens. However, respiratory pathogen transmission in such confined settings in the tropics has not been well studied. METHODS: Recruits in four successive Royal Thai Army basic training classes living in mil... |
Transboundary spread of pig diseases: the role of international trade and travel | As globalization increases the interconnectedness between nations, economies, and industries, the introduction of diseases will continue to remain a prominent threat to the livestock sector and the trade of animals and animal products, as well as the livelihoods of farmers, food security and public health. The global p... |
IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice | Abstract T helper 1-driven immune responses have been implicated in protective immunity against viral infections. Interleukin (IL)-12 is a heterodimeric proinflammatory cytokine formed by a p35 and a p40 subunit that can induce differentiation of naïve T cells towards a T helper 1-response. To determine the role of IL-... |
Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives | ABSTRACT: A series of indole-based spirothiazolidinones have been designed, synthesized and evaluated, in vitro, for their antitubercular, antiviral, antibacterial, and antifungal activities. The structures of the new compounds were established by IR, (1)H NMR, (13)C NMR (proton decoupled, APT, and DEPT), electrospray ... |
MicroR‐9‐5p suppresses EV71 replication through targeting NFκB of the RIG‐I‐mediated innate immune response | Accumulating evidence demonstrates that there is a causative link between hsa‐microRNA‐9‐5p (miR‐9) and pathophysiological processes. Enterovirus 71 (EV71) has been found to contribute to numerous severe clinical symptoms which result in death. The exact mechanism by which EV71 influences miR‐9 expression is unknown, a... |
VIRUSES OF THE LUNG | Respiratory viruses include rhinoviruses and enteroviruses (Picornaviridae), influenza viruses (Orthomyxoviridae), parainfluenza, metapneumoviruses and respiratory syncytial viruses (Paramyxoviridae), coronaviruses (Coronaviridae), and several adenoviruses. With the exception of adenoviruses, all possess an RNA genome.... |
European Union training programme for tuberculosis laboratory experts: design, contribution and future direction | BACKGROUND: Tuberculosis (TB) control programmes rely heavily on laboratories to support both clinical care and public health. Qualified personnel with adequate technical and managerial skills comprise an integral component of any quality assured laboratory. Training a new generation of TB laboratory specialists was id... |
Let’s talk about sex in the context of COVID-19 | In recent months, the coronavirus disease 2019 (COVID-19) pandemic has sent many countries into crisis. Studies have shown that this virus causes worse outcomes and a higher mortality in men than in women. It has been recognized that sex can affect the immune response to a pathogenic agent, as well as the susceptibilit... |
What’s Important: COVID-19—Helpers, Not Heroes | |
Anesthesiology, the Tragedy of the Commons, and Coronavirus Disease 2019 | |
Chinese immigrant parents’ vaccination decision making for children: a qualitative analysis | BACKGROUND: While immunization coverage rates for childhood routine vaccines in Hong Kong are almost 100%, the uptake rates of optional vaccines remain suboptimal. Understanding parental decision-making for children’s vaccination is important, particularly among minority groups who are most vulnerable and underserved. ... |
A “Syndromic” Approach for Diagnosing and Managing Travel-Related Infectious Diseases in Children | |
Vaccination antivirale et immunité muqueuse respiratoire Un concept séduisant pour des résultats encore décevants | Points essentiels • Les surfaces muqueuses de l’arbre respiratoire constituent une porte d’entrée très importante et un site critique pour la réponse immune. Les principaux anticorps sécrétés localement appar-tiennent à l’isotype IgA (S-Ig A). Les cellules effectrices qui dominent au niveau de la muqueuse ne sont pas d... |
Evolution and resolution of brain involvement associated with SARS- CoV2 infection: A close Clinical – Paraclinical follow up study of a case | The new severe acute respiratory syndrome- coronavirus 2 is reported to affect the nervous system. Among the reports of the various neurological manifestations, there are a few documented specific processes to explain the neurological signs. We report a para-infectious encephalitis patient with clinical, laboratory, an... |
Neutrophil extracellular traps and thrombosis in COVID-19 | Here, we report on four patients whose hospitalizations for COVID-19 were complicated by venous thromboembolism (VTE). All demonstrated high levels of D-dimer as well as high neutrophil-to-lymphocyte ratios. For three patients, we were able to test sera for neutrophil extracellular trap (NET) remnants and found signifi... |
Towards a ‘virtual’ world: Social isolation and struggles during the COVID‐19 pandemic as single women living alone | This article is a personal reflection of how the current COVID‐19 pandemic affects our working lives and wellbeing, as single female academics who live alone in the UK. We offer a dialogue of our daily lives of being confined at home with lockdown measures extended. In particular, we focus on the experience of, and cop... |
Outcome of trauma and orthopaedic surgery at a UK District General Hospital during the Covid-19 pandemic | INTRODUCTION: There are suggestions that elective surgery performed during the incubation period of COVID-19 infection may cause an immediate impairment of cell-mediated immunity, leading to high morbidity and mortality. However is contrasting data about the associated mortality. Since the outbreak, our unit has mainta... |
A discussion of irrational stockpiling behaviour during crisis | Abstract One of the ubiquitous human behaviours observed in natural disasters and humanitarian crisis is irrational stockpiling (also known as hoarding or panic buying). Limited, distorted and exaggerated information during crisis disturbs people's judgement and results in aberrant actions which can be explained with e... |
Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations | Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) can be associated with various disorders. Recent investigation has involved clinical studies in collaboration with clinical investigators and pathologists on the pathogenetic mechanisms of ALI or ARDS caused by various disorders. This literature revi... |
Paediatric airway infections | |
Made-to-measure Microbes | |
Detection and characterization of diverse alpha- and betacoronaviruses from bats in China | Bats have been implicated as important reservoir hosts of alpha- and betacoronaviruses. In this study, diverse coronaviruses (CoVs) were detected in 50 of 951 (positive rate 5.3%) intestinal specimens of eight bat species collected in four provinces and the Tibet Autonomous Region of China by pan-coronavirus RT-PCR scr... |
The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates | |
Letter from the United States: A New York experience with COVID‐19 | |
Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs | RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA), and results in the silencing of homologous gene expression through the specific degradation of an mRNA containing the same sequence. dsRNA-mediated RNAi can be used in a wide variety of eucaryotes to induce the sequence-specific inhi... |
Overall synthesis and conclusions | Abstract This chapter first systematically summarizes the most important findings and policy implications of each of the chapters “Factors affecting traffic flow efficiency implications of connected and autonomous vehicles: A review and policy recommendations” by Narayanan et al.; “Automated bus systems in Europe: A sy... |
Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2 | To face SARS-CoV-2 pandemic various attempts are made to identify potential effective treatments by repurposing available drugs. Among them, indomethacin, an anti-inflammatory drug, was shown to have potent in-vitro antiviral properties on human SARS-CoV-1, canine CCoV, and more recently on human SARS-CoV-2 at low micr... |
Global stability for an epidemic model with applications to feline infectious peritonitis and tuberculosis | Abstract A general compartmental model of disease transmission is studied. The generality comes from the fact that new infections may enter any of the infectious classes and that there is an ordering of the infectious classes so that individuals can be permitted (or not) to pass from one class to the next. The model in... |
COVID‐19 and its implications for Dermatology and Venereology | |
CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation | PURPOSE: To introduce the COVID-19 Reporting and Data System (CO-RADS) for standardized assessment of pulmonary involvement of COVID-19 on non-enhanced chest CT and report its initial interobserver agreement and performance. METHODS: The Dutch Radiological Society (NVvR) developed CO-RADS based on other efforts for sta... |
Attenuation of antibody response to SARS-CoV-2 in a patient on ocrelizumab with hypogammaglobulinemia. | |
Development and Prospective Validation of a Transparent Deep Learning Algorithm for Predicting Need for Mechanical Ventilation | IMPORTANCE: Objective and early identification of hospitalized patients, and particularly those with novel coronavirus disease 2019 (COVID-19), who may require mechanical ventilation is of great importance and may aid in delivering timely treatment. OBJECTIVE: To develop, externally validate and prospectively test a tr... |
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells | Coronavirus tropism is predominantly determined by the interaction between coronavirus spikes and the host receptors. In this regard, coronaviruses have evolved a complicated receptor-recognition system through their spike proteins. Spikes from highly related coronaviruses can recognize distinct receptors, whereas spik... |
The synthetic futures of vesicular stomatitis virus | |
Evidence for mutations in SARS‐CoV‐2 Italian isolates potentially affecting virus transmission | Italy is the first western country suffering heavy SARS‐CoV‐2 transmission and disease impact after Covid‐19 pandemia started in China. Even though the presence of mutations on spike glycoprotein and nucleocapsid in Italian isolates has been reported, the potential impact of these mutations on viral transmission has no... |
Anti HSV-1 Activity of Halistanol Sulfate and Halistanol Sulfate C Isolated from Brazilian Marine Sponge Petromica citrina (Demospongiae) | The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus ... |
Human Sialome and Coronavirus Disease-2019 (COVID-19) Pandemic: An Understated Correlation? | |
Proteome and phosphoproteome analysis of honeybee (Apis mellifera) venom collected from electrical stimulation and manual extraction of the venom gland | BACKGROUND: Honeybee venom is a complicated defensive toxin that has a wide range of pharmacologically active compounds. Some of these compounds are useful for human therapeutics. There are two major forms of honeybee venom used in pharmacological applications: manually (or reservoir disrupting) extracted glandular ven... |
Lycorine: A prospective natural lead for anticancer drug discovery | Abstract Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid with immense therapeutic potential. Lycorine is active in a very low concentration and with high specificity against a number of cancers both in vivo and in vitro and against various drug-resistant cancer cells. This re... |
Initial performance evaluation of a spotted array Mobile Analysis Platform (MAP) for the detection of influenza A/B, RSV, and MERS coronavirus | Abstract Clinical samples were evaluated with the Mobile Analysis Platform (MAP) to determine platform performance for detecting respiratory viruses in samples previously characterized using clinical reverse transcriptase polymerase chain reaction assays. The percent agreement between MAP and clinical results was 97% f... |
Effects of metals on sperm quality, fertilization and hatching rates, and embryo and larval survival of pejerrey fish (Odontesthes bonariensis) | Some species of fish have been used as bioindicators of aquatic environmental pollution all over the world. Pejerrey (Odontesthes bonariensis) was selected for the current study due to its sensitivity to pollutants and because is one of the emblematic fish species that inhabits shallow lakes of the Pampa region (Argent... |
Training Nurses to Better Deal With Ethical Dilemmas During Pandemics | |
"Strategic cardiac catheterization lab staffing in the era of COVID-19" | |
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes | Biotin-labeled molecular probes, comprising specific regions of the SARS-CoV-2 spike, would be helpful in the isolation and characterization of antibodies targeting this recently emerged pathogen. To develop such probes, we designed constructs incorporating an N-terminal purification tag, a site-specific protease-cleav... |
On-farm biosecurity practices and causes of preweaning mortality in Canadian commercial mink kits | BACKGROUND: Mink are an important animal commodity group in Canada and excessive kit mortality represents a significant loss to production. National biosecurity standards have been developed for Canadian mink farms, but it is unclear how well these standards have been implemented as there are no studies correlating man... |
Molecular epidemiology of respiratory viruses in virus-induced asthma | Acute respiratory illness (ARI) due to various viruses is not only the most common cause of upper respiratory infection in humans but is also a major cause of morbidity and mortality, leading to diseases such as bronchiolitis and pneumonia. Previous studies have shown that respiratory syncytial virus (RSV), human rhino... |
The Use of Aspirated Consonants during Speech may Increase the Transmission of COVID-19 | |
SARS: clinical virology and pathogenesis | Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, called the SARS coronavirus (SARS‐CoV). Over 95% of well characterized cohorts of SARS have evidence of recent SARS‐CoV infection. The genome of SARS‐CoV has been sequenced and it is not related to any of the previously known human or animal cor... |
Preparedness for COVID-19 infection prevention in Korea: Single-center experience | |
Plant Viral Proteases: Beyond the Role of Peptide Cutters | Almost half of known plant viral species rely on proteolytic cleavages as key co- and post-translational modifications throughout their infection cycle. Most of these viruses encode their own endopeptidases, proteases with high substrate specificity that internally cleave large polyprotein precursors for the release of... |
Community‐acquired pneumonia: An Asia Pacific perspective | |
Safety for all: coronavirus disease 2019 pandemic and cardiac surgery: a roadmap to ‘phase’ 2 | |
Refined Estimate of the Incubation Period of Severe Acute Respiratory Syndrome and Related Influencing Factors | Many epidemiologists have agreed that a refined estimate of the incubation period of severe acute respiratory syndrome (SARS) would need a sample size of about 200 cases and appropriate statistical methods enabling the inclusion of cases with defined periods of exposure. However, no such studies have been reported so f... |
Globalization of Communicable Diseases | Abstract Fueled by globalization and human behavior, communicable diseases pose a serious threat to humankind despite unparalleled technological advances. New viruses and devastating communicable diseases such as Ebola and Zika are emerging; diseases previously considered eradicated such as measles are reemerging, whil... |
Survival of Severe Acute Respiratory Syndrome Coronavirus | Background. The primary modes of transmission of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) appear to be direct mucus membrane contact with infectious droplets and through exposure to formites. Knowledge of the survival characteristics of the virus is essential for formulating appropriate infection... |
Tratamiento farmacológico de las agudizaciones infecciosas de la EPOC | Las agudizaciones de la enfermedad pulmonar obstructiva crónica (EPOC) son episodios frecuentes y potencialmente graves, que dejan un impacto permanente en la calidad de vida y en la función pulmonar de los pacientes. Hasta un 75% de las agudizaciones tiene una etiología bacteriana, en ocasiones asociada a infección ví... |
Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection | OBJECTIVE: This study aimed to evaluated the diagnostic performance of the Abbott Architect SARS-CoV-2 IgG assay in COVID-19 patients. METHODS: Residual sera from 177 symptomatic COVID-19 positive patients, and 163 non-COVID-19 patients were tested for antibody with the Abbott SARS-CoV-2 IgG assay (Abbott Diagnostics, ... |
Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery | Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the... |
Influenza and Influenza-like Viruses in Children in the Epidemic Season 2015/2016 in Poland | Influenza is an infectious disease caused by influenza A and B viruses. Children are the group which is the most exposed to influenza and influenza-like infections. They are considered as carriers of influenza infections in the population. In the epidemic season 2015/2016 more than 8000 samples were tested, of which ov... |
PSGL-1 inhibits the virion incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins and impairs virus attachment and infectivity | P-selectin glycoprotein ligand-1 (PSGL-1) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 has been identified as an interferon-γ (INF-γ)-regulated factor that rest... |
Hydroxychloroquine and “off-label” utilization in the treatment of oral conditions | |
SARS, Xenotransplantation and Bioterrorism: Preventing the Next Epidemic | |
Antiviral Chemotherapy | Over the past 20 years, antiviral therapy has undergone a revolution and is now making a significant impact on the treatment of major virus diseases, for example HIV and viral hepatitis B and C. Targets include viral reverse transcriptases and proteases. The use of interferon to boost host immunity has also proved effe... |
Point-of-Care Microdevices for Blood Plasma Analysis in Viral Infectious Diseases | Each year, outbreaks of viral infections cause illness, disability, death, and economic loss. As learned from past incidents, the detrimental impact grows exponentially without effective quarantine. Therefore, rapid on-site detection and analysis are highly desired. In addition, for high-risk areas of viral contaminati... |
Letter: Implementation of a Neurosurgery Telehealth Program Amid the COVID-19 Crisis—Challenges, Lessons Learned, and a Way Forward | |
Reply to “MRI evaluation of the olfactory clefts in patients with SARS-CoV-2 infection revealed an unexpected mechanism for olfactory function loss” | |
Shortlisting SARS‐CoV‐2 Peptides for Targeted Studies from Experimental Data‐Dependent Acquisition Tandem Mass Spectrometry Data | Detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a crucial tool for fighting the COVID‐19 pandemic. This dataset brief presents the exploration of a shotgun proteomics dataset acquired on SARS‐CoV‐2 infected Vero cells. Proteins from inactivated virus samples were extracted, digested with tr... |
Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection | BACKGROUND: The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern ... |
CD13/aminopeptidase N in collagen vascular diseases | To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due ... |
Visualisation of epidemiological map using an Internet of Things infectious disease surveillance platform | |
Early‐stage predictors of the acute phase duration in uncomplicated COVID‐19 pneumonia | OBJECTIVE: In this study, we aimed to highlight the common early‐stage clinical and laboratory variables independently related to the acute phase duration in patients with uncomplicated coronavirus disease (COVID‐19) pneumonia. METHODS: In hospitalized patients, the acute phase disease duration was followed using the B... |
What’s really ‘Happning’? A forensic analysis of Android and iOS Happn dating apps | With today’s world revolving around online interaction, dating applications (apps) are a prime example of how people are able to discover and converse with others that may share similar interests or lifestyles, including during the recent COVID-19 lockdowns. To connect the users, geolocation is often utilized. However,... |
Chapter 29 Role of Immune and Autoimmune Dysfunction in Schizophrenia | Abstract In this chapter, we review data in support of the concept that immune system dysregulation is the most plausible explanation that reconciles gene by environmental interactions in schizophrenia. Early investigations of this topic demonstrated aspects of aberrant activation of humoral immunity, including autoimm... |
A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection | Transmissible gastroenteritis coronavirus (TGEV) is a member of the genus Coronavirus, family Coronaviridae, order Nidovirales. TGEV is an enteropathogenic coronavirus that causes highly fatal acute diarrhoea in newborn pigs. An oral Lactobacillus casei (L. casei) vaccine against anti-transmissible gastroenteritis viru... |
Surveillance of Airborne Adenovirus and Mycoplasma pneumoniae in a Hospital Pediatric Department | This investigation evaluated the distributions of airborne adenovirus and Mycoplasma pneumoniae in public areas in the pediatric department of Children's Hospital in northern Taiwan. The airborne viral and bacterial concentrations were evaluated twice a week for a year using filter sampling with an airflow rate of 12 l... |
Evaluation of a potential reintroduction of nuclear energy in Italy to accelerate the energy transition | Abstract Nuclear energy was adopted in Italy in the past to deal with the insufficient fossil fuels on the national territory. After a public vote subsequent to the Chernobyl accident, Italy abandoned the use of nuclear energy and nowadays adopts a mix of fossil fuels and renewable energy sources for electricity produc... |
Prioritizing and Analyzing the Role of Climate and Urban Parameters in the Confirmed Cases of COVID-19 Based on Artificial Intelligence Applications | Nowadays, an infectious disease outbreak is considered one of the most destructive effects in the sustainable development process. The outbreak of new coronavirus (COVID-19) as an infectious disease showed that it has undesirable social, environmental, and economic impacts, and leads to serious challenges and threats. ... |
Factors Associated with Psychosis among Patients with Severe Acute Respiratory Syndrome: A Case-Control Study | We observed that a number of patients with severe acute respiratory syndrome (SARS) developed affective psychosis during the acute phase of their illness. We reviewed all SARS-related psychiatric consultations in Hong Kong and investigated the risk factors for psychosis among patients with SARS in a matched case-contro... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.