title stringlengths 0 221 | text stringlengths 0 375k |
|---|---|
Rabies-Related Knowledge and Practices Among Persons At Risk of Bat Exposures in Thailand | BACKGROUND: Rabies is a fatal encephalitis caused by lyssaviruses. Evidence of lyssavirus circulation has recently emerged in Southeast Asian bats. A cross-sectional study was conducted in Thailand to assess rabies-related knowledge and practices among persons regularly exposed to bats and bat habitats. The objectives ... |
A logistic growth model for COVID-19 proliferation: experiences from China and international implications in infectious diseases | Abstract Objective As the COVID-19 global pandemic continues its proliferation globally, this paper shares the findings and experiences of modelling the outbreak in China and its provinces and proposes implications for the study of infectious diseases and the COVID-19 pandemic in other nations. Methods An NLS (non-line... |
Amelioration of oxidative stress using N‐acetylcysteine in canine parvoviral enteritis | Previously, antioxidants have not been evaluated for treatment of parvoviral diarrhea in dogs. In this study, antioxidant potential of N‐acetylcysteine (NAC) in dogs infected with canine parvovirus with a nonblinded randomized clinical trial has been carried out. A total 18 parvo‐infected dogs were randomly divided int... |
Single- and multiple viral respiratory infections in children: disease and management cannot be related to a specific pathogen | BACKGROUND: The number of viral pathogens associated with pediatric acute respiratory tract infection (ARI) has grown since the introduction of reverse transcription real-time polymerase chain reaction (RT-PCR) assays. Multiple viruses are detected during a single ARI episode in approximately a quarter of all cases. Th... |
Methods to infer transmission risk factors in complex outbreak data | Data collected during outbreaks are essential to better understand infectious disease transmission and design effective control strategies. But analysis of such data is challenging owing to the dependency between observations that is typically observed in an outbreak and to missing data. In this paper, we discuss strat... |
Coronavirus disease 2019: International public health considerations | On December 31, 2019, the Chinese government announced an outbreak of a novel coronavirus, recently named COVID‐19. During the following weeks the international medical community has witnessed with unprecedented coverage the public health response both domestically by the Chinese government, and on an international sca... |
Tracking the viruses that cause the Hajj cough | The first study to track viral infection over an entire pilgrimage to Mecca sheds light on the Hajj cough – and how the deadly MERS virus might spread |
Salivary gland disease in the era of COVID‐19 pandemic | Coronavirus disease 2019 (COVID‐19) pandemic forced significant changes in current approach to outpatient evaluation of common otolaryngology complaints as hospitals around the world are trying to limit the spread of the virus and to preserve health care resources. These changes raise a lot of questions regarding patie... |
9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate | Sialic acids, terminal sugars of glycoproteins and glycolipids, play important roles in development, cellular recognition processes and host–pathogen interactions. A common modification of sialic acids is 9-O-acetylation, which has been implicated in sialoglycan recognition, ganglioside biology, and the survival and dr... |
Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19 | Abstract The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused global public health and economic crises necessitating rapid development of vaccines and therapeutic countermeasures. The world-wide response to the COVID-19 pandemic has been unprecedented with government, academic and private partne... |
Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model | Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic (PBPK) model for predicting tissue distribution of CQ and apply it to optimize dosage regimens, a PBPK model, with parameterization of drug... |
Global measles elimination | Measles remains a leading vaccine-preventable cause of child mortality worldwide, particularly in sub-Saharan Africa where almost half of the estimated 454,000 measles deaths in 2004 occurred. However, great progress in measles control has been made in resource-poor countries through accelerated measles-control efforts... |
Houttuynia cordata Targets the Beginning Stage of Herpes Simplex Virus Infection | Herpes simplex virus (HSV), a common latent virus in humans, causes certain severe diseases. Extensive use of acyclovir (ACV) results in the development of drug-resistant HSV strains, hence, there is an urgent need to develop new drugs to treat HSV infection. Houttuynia cordata (H. cordata), a natural herbal medicine, ... |
Exploring global food system shocks, scenarios and outcomes | Globalised food supply chains are increasingly susceptible to systemic risks, with natural, social and economic shocks in one region potentially leading to price spikes and supply changes experienced at the global scale. When projections extrapolate from recent histories and adopt a ‘business as usual’ approach they ri... |
How to make predictions about future infectious disease risks | Formal, quantitative approaches are now widely used to make predictions about the likelihood of an infectious disease outbreak, how the disease will spread, and how to control it. Several well-established methodologies are available, including risk factor analysis, risk modelling and dynamic modelling. Even so, predict... |
Epidemiology and Immune Pathogenesis of Viral Sepsis | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can be caused by a broad range of pathogens; however, bacterial infections represent the majority of sepsis cases. Up to 42% of sepsis presentations are culture negative, suggesting a non-bacterial cause. Despite ... |
Chapter 8 The peritoneum | |
Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19) | The severe acute respiratory coronavirus 2 (SARS-CoV-2), which emerged in December 2019 in Wuhan, China, has spread rapidly to over a dozen countries. Especially, the spike of case numbers in South Korea sparks pandemic worries. This virus is reported to spread mainly through person-to-person contact via respiratory dr... |
IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation | As the only flying mammal, bats harbor a number of emerging and re-emerging viruses, many of which cause severe diseases in humans and other mammals yet result in no clinical symptoms in bats. As the master regulator of the interferon (IFN)-dependent immune response, IFN regulatory factor 7 (IRF7) plays a central role ... |
Toward a resolution of the cost of equity conundrum in the lodging industry: a conceptual framework | The firm value estimate is derived from accounting and finance practices that focus on physical assets as opposed to intangible assets (Arthur Andersen Hospitality Leisure Executive Rep. 5 (1998) 2). The cost of equity estimation models used in firm valuation and capital investment decisions fall short of tapping impor... |
Public health interventions for epidemics: implications for multiple infection waves | BACKGROUND: Epidemics with multiple infection waves have been documented for some human diseases, most notably during past influenza pandemics. While pathogen evolution, co-infection, and behavioural changes have been proposed as possible mechanisms for the occurrence of subsequent outbreaks, the effect of public healt... |
Human picornavirus and coronavirus RNA in nasopharynx of children without concurrent respiratory symptoms | The prevalence of human rhino‐, entero‐, and coronaviruses was investigated by RT‐PCR in nasopharyngeal aspirates from 107 children without concurrent respiratory symptoms. The children were admitted to the hospital for elective surgery. The parents filled a questionnaire about the occurrence of respiratory symptoms fo... |
Is the brain a reservoir organ for SARS2‐CoV2? | Paniz-Mondolfi et al have published an interesting necropsy case of a patient with Parkinson's disease and SARS2-CoV infection in which the virus is found in neurons of the frontal lobe. The authors analyze these findings about the possibility that the brain is a reservoir of the virus as has been observed with other C... |
Addendum to: Eruption as a clinical manifestation of COVID-19: Photographs of a patient | |
Mental Health Status of the General Population in Japan during the COVID‐19 Pandemic | |
China and SARS: could do better | Has the world's most populous nation learnt the lessons of last year's SARS outbreak? Only partially, it seems. |
Analysis of SARS-CoV-2 Screening Clinic (Including Drive-Through System) Data at a Single University Hospital in South Korea from 27 January 2020 to 31 March 2020 during the COVID-19 Outbreak. | In this study, we evaluated the efficiency of a drive-through (DT) screening system for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by comparing it with a conventional screening system. We reviewed and analyzed the SARS-CoV-2 screening data obtained at our university hospital. We compared the number of... |
Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2 | KEY MESSAGE: Laboratory characteristics of SARS-CoV-2 infection did not differ between pregnant and non-pregnant women. A trend of lower lymphocyte count was observed in the pregnant women group PURPOSE: Laboratory abnormalities, which characterize SARS-CoV-2 infection have been identified, nevertheless, data concernin... |
The virulence of mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage and cell-to-cell fusion | The cleavage and fusion properties of recombinant murine hepatitis viruses (MHV) were examined to assess the role of the cleavage signal in determining the extent of S protein cleavage, and the correlation between cleavage and induction of cell-to-cell fusion. Targeted recombination was used to introduce amino acid sub... |
EWI‐2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry | CD81 is a major receptor for Hepatitis C Virus (HCV). It belongs to the tetraspanin family whose members form dynamic clusters with numerous partner proteins and with one another, forming tetraspanin‐enriched areas in the plasma membrane. In our study, we combined single‐molecule microscopy and biochemistry experiments... |
Prioritizing elective cardiovascular procedures during the COVID‐19 pandemic: The cardiovascular medically necessary, time‐sensitive procedure scorecard | BACKGROUND: Following the surge of the coronavirus disease 2019 (COVID‐19) pandemic, government regulations, and recommendations from professional societies have conditioned the resumption of elective surgical and cardiovascular (CV) procedures on having strategies to prioritize cases because of concerns regarding the ... |
Self-quarantine and Weight Gain Related Risk Factors During the COVID-19 Pandemic | OBJECTIVE: The purpose of this study was to quantify the impact that self-quarantine has on behaviors associated with weight gain. METHODS: This was a quantitative descriptive/correlational research design. Research announcement was sent out via Facebook to 1200 possible participants. Six surveys were condensed into a ... |
Global service‐learning and COVID‐19—What the future might look like? | The novel coronavirus disease (COVID-19) pandemic has disrupted travel and caused marked death and disability globally. The economic impact of this change has forced universities to operate differently in how they conduct their operations and deliver education to students (Jackson et al. 2020). Leveraging digital modal... |
Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibits Extra Villous Trophoblast Migration: The Impact of Bacterial and Viral Infection | Extravillous trophoblasts (EVT) migration into the decidua is critical for establishing placental perfusion and when dysregulated, may lead to pre-eclampsia (PE) and intrauterine growth restriction (IUGR). The breast cancer resistance protein (BCRP; encoded by ABCG2) regulates the fusion of cytotrophoblasts into syncyt... |
Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of COVID-19 | Abstract There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well established as a re... |
Relationship-Oriented Cultures, Corruption, and International Marketing Success | This study explores the general problems associated with marketing across international markets and focuses specifically on the role of corruption in deterring international marketing success. The authors do this by introducing a broader conceptualization of corruption. The dimensions of corruption and their importance... |
Development of a Chimeric DNA-RNA Hammerhead Ribozyme Targeting SARS Virus | OBJECTIVE: Severe acute respiratory syndrome (SARS) is a severe pulmonary infectious disease caused by a novel coronavirus. To develop an effective and specific medicine targeting the SARS-coronavirus (CoV), a chimeric DNA-RNA hammerhead ribozyme was designed and synthesized using a sequence homologous with the mouse h... |
Personal protective equipment (PPE) for anesthesiologists: the need for national guidelines | |
Using the diagnostic model based on routine laboratory tests to distinguish patients infected with SARS-CoV-2 from those infected with influenza virus | Abstract Background The differential diagnosis between novel coronavirus pneumonia patients (NCPP) and influenza patients (IP) remains a challenge in clinical practice. Methods Between January 2018 and March 2020, 1027 NCPP and 1140 IP were recruited from Tongji hospital. Blood routine examination, biochemical indicato... |
Different location, same results? | http://onlinelibrary.wiley.com/doi/10.1111/resp.13049/abstract |
Cardiomyopathies—past, present, future | |
Convolutional CapsNet: A novel artificial neural network approach to detect COVID-19 disease from X-ray images using capsule networks | Coronavirus is an epidemic that spreads very quickly. For this reason, it has very devastating effects in many areas worldwide. It is vital to detect COVID-19 diseases as quickly as possible to restrain the spread of the disease. The similarity of COVID-19 disease with other lung infections makes the diagnosis difficul... |
Use Mascara: The Trajectory of COVID‐19 in the Favela Rocinha | |
COVID-19 Testing, Epidemic Features, Hospital Outcomes, and Household Prevalence, New York State—March 2020 | BACKGROUND: The United States’ COVID-19 epidemic has grown extensively since February 2020, with substantial associated hospitalizations and mortality; New York State (NYS) has emerged as the national epicenter. We report on the extent of testing and test results during the month of March in NYS, along with risk factor... |
Evaluation of the auxiliary diagnostic value of antibody assays for the detection of novel coronavirus (SARS‐CoV‐2) | The spread of SARS‐CoV‐2 has taken on pandemic proportions, affecting over 100 countries in a matter of weeks. The goal of this study was to assess the diagnostic values of different methods of detecting and estimating the SARS‐CoV‐2 infection, and the auxiliary diagnostic potential of antibody assays. By retrospective... |
Endocrine Disruption and Obesity: A current review on Environmental Obesogens | Abstract Obesity represents an important public health concern because it substantially increases the risk of multiple chronic diseases and thereby contributing to a decline in both quality of life and life expectancy. Besides unhealthy diet, physical inactivity and genetic susceptibility, environmental pollutants also... |
Is there a link between viruses and necrotising enterocolitis? | |
Evaluation of fluid responsiveness during COVID-19 pandemic: what are the remaining choices? | Non-protocolized fluid administration in critically ill patients, especially those with acute respiratory distress syndrome (ARDS), is associated with poor outcomes. Therefore, fluid administration in patients with Coronavirus disease (COVID-19) should be properly guided. Choice of an index to guide fluid management du... |
Viral etiology of community-acquired infection in Vietnam: unraveling the unknown by next-generation sequencing analysis | |
Genetic Predisposition Models to COVID-19 Infection | |
Environmental Impact, Concept and Measurement of | Abstract Environments on Earth are always changing, and living systems evolve within them. For most of their history, human beings did the same. But in the last two centuries, humans have become the planet's dominant species, changing and impoverishing the environment for all life on Earth and even decimating humans' o... |
MANAGEMENT OF COMMON MINOR DISCOMFORTS IN PREGNANCY: Part I: Managing Upper Respiratory Infections in Pregnancy | The minor discomforts of pregnancy present difficulties for the health care provider as well as for the pregnant woman herself. Management of the various symptoms requires astute observations and the ability to individualize therapy. Knowledge of a variety of treatment options, therefore, allows practitioners to collab... |
Chronic Cough Due to Chronic Bronchitis ACCP Evidence-Based Clinical Practice Guidelines | Background: Chronic bronchitis is a disease of the bronchi that is manifested by cough and sputum expectoration occurring on most days for at least 3 months of the year and for at least 2 consecutive years when other respiratory or cardiac causes for the chronic productive cough are excluded. The disease is caused by a... |
Advances on Antiviral Activity of Morus spp. Plant Extracts: Human Coronavirus and Virus-Related Respiratory Tract Infections in the Spotlight | (1) Background: Viral respiratory infections cause life-threatening diseases in millions of people worldwide every year. Human coronavirus and several picornaviruses are responsible for worldwide epidemic outbreaks, thus representing a heavy burden to their hosts. In the absence of specific treatments for human viral i... |
Evaluation of the influenza-like illness surveillance system in Tunisia, 2012–2015 | BACKGROUND: This study was initiated to evaluate, for the first time, the performance and quality of the influenza-like illness (ILI) surveillance system in Tunisia. METHODS: The evaluation covered the period of 2012–2015 and used different data sources to measure indicators related to data quality and completeness, re... |
Could SARS‐CoV‐2 affect male fertility? | We performed this systematic review to evaluate the possibility of an impact of SARS‐CoV‐2 infection on male fertility. SARS‐CoV‐2 enters the cells with the help of ACE2; therefore, testicular expression of ACE2 was analysed from transcriptome sequencing studies and our unpublished data. Literature suggested that SARS‐... |
Haematological manifestations, mechanisms of thrombosis and anti-coagulation in COVID-19 disease: A review | Coronavirus-19 disease (COVID-19), a zoonosis, was first reported in the city of Wuhan, province of Hubei, China in December 2019. The disease is caused by the Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2). As of 12(th) of May 2020, 4,256,022 confirmed cases affecting 212 countries with 287,332 deaths ha... |
Peptide inhibitors of dengue virus and West Nile virus infectivity | Viral fusion proteins mediate cell entry by undergoing a series of conformational changes that result in virion-target cell membrane fusion. Class I viral fusion proteins, such as those encoded by influenza virus and human immunodeficiency virus (HIV), contain two prominent alpha helices. Peptides that mimic portions o... |
Prophylaxis using paromomycin of natural cryptosporidial infection in neonatal kids | Abstract The chemoprophylactic effects of paromomycin sulfate against natural cryptosporidiosis in young kids were investigated. Two studies were carried out using two groups of 18 and 12 animals in two pens. In each pen, kids were allocated to treated or control groups. The treatment consisted of oral paromomycin give... |
Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 | |
Survival study of hospitalised patients with concurrent COVID‐19 and haematological malignancies | The prevalence of cancer in patients with the novel coronavirus disease 2019 (Covid-19), caused by the SARS-CoV-2 infection, is uncertain. In a pooled meta-analysis including 11 retrospective studies, the prevalence of cancer was 2% (Desai et al, 2020). Patients with cancer and Covid-19 have been described to have a hi... |
Investigating carbon tax pilot in YRD urban agglomerations—Analysis of a novel ESER system with carbon tax constraints and its application | Abstract This paper attempts to explore carbon tax pilot in Yangtze River Delta (YRD) urban agglomerations based on a novel energy-saving and emission-reduction (ESER) system with carbon tax constraints, which has not yet been discussed in present literature. A novel carbon tax attractor is achieved through the discuss... |
Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future | The respiratory system consists of an integrated network of organs and structures that primarily function for gas exchange. In mammals, oxygen and carbon dioxide are transmitted through a complex respiratory tract, consisting of the nasal passages, pharynx, larynx, and lung. Exposure to ambient air throughout the lifes... |
Enhancing safety of laparoscopic surgery in COVID-19 era: clinical experience with low-cost filtration devices | BACKGROUND: Surgery in the era of the current COVID-19 pandemic has been curtailed and restricted to emergency and certain oncological indications, and requires special attention concerning the safety of patients and health care personnel. Desufflation during or after laparoscopic surgery has been reported to entail a ... |
Readaptation of surgical practice during COVID‐19 outbreak: what has been done, what is missing and what to expect | |
Favorable Outcome After COVID-19 Infection in a Multiple Sclerosis Patient Initiated on Ocrelizumab During the Pandemic | |
Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study | AIMS: It remains unknown whether the treatment of hypertension influences the mortality of patients diagnosed with coronavirus disease 2019 (COVID-19). METHODS AND RESULTS: This is a retrospective observational study of all patients admitted with COVID-19 to Huo Shen Shan Hospital. The hospital was dedicated solely to ... |
Selection and validation of suitable reference genes for qPCR gene expression analysis in goats and sheep under Peste des petits ruminants virus (PPRV), lineage IV infection | Identification of suitable candidate reference genes is an important prerequisite for validating the gene expression data obtained from downstream analysis of RNA sequencing using quantitative real time PCR (qRT-PCR). Though existence of a universal reference gene is myth, commonly used reference genes can be assessed ... |
Role of vaccine efficacy in the vaccination behavior under myopic update rule on complex networks | Abstract How to effectively prevent the diffusion of infectious disease has become an intriguing topic in the field of public hygienics. To be noted that, for the non-periodic infectious diseases, many people hope to obtain the vaccine of epidemics in time to be inoculated, rather than at the end of the epidemic. Howev... |
The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies | A new Severe Acute Respiratory Syndrome Coronavirus variant (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus present with clinically inapparent, mild or severe disease. Currently, the presence of the virus in indi... |
Universal virus detection by degenerate-oligonucleotide primed polymerase chain reaction of purified viral nucleic acids | Summary This study describes a novel non-specific universal virus detection method that permits molecular detection of viruses in biological materials containing mixtures of cells and viruses. Samples are subjected to nuclease digestion and ultracentrifugation to separate encapsidated viral nucleic acids from cellular ... |
Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2 | Summary The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target. Here, we describe the near-atomic resolution structure of t... |
Psychosocial impact of COVID-19-related quarantine: reflections after the first case of suicide in Colombia/ Impacto psicosocial de la cuarentena debido a la COVID-19: reflexiones tras el primer caso de suicidio en Colombia/ Impacto psicossocial da quarentena pela COVID-19: reflexões sobre o primeiro caso de suicídio n... | |
Assessing the potential impact on health of the UK's future relationship agreement with the EU: analysis of the negotiating positions | While policy attention is understandably diverted to COVID-19, the end of the UK's post-Brexit ‘transition period’ remains 31 December 2020. All forms of future EU−UK relationship are worse for health than EU membership, but analysis of the negotiating texts shows some forms are better than others. The likely outcomes ... |
COVID‐19: are neutralizing antibodies neutralizing enough? | |
Mitigating the risk of Zika virus contamination of raw materials and cell lines in the manufacture of biologicals | Ensuring the virological safety of biologicals is challenging due to the risk of viral contamination of raw materials and cell banks, and exposure during in-process handling to known and/or emerging viral pathogens. Viruses may contaminate raw materials and biologicals intended for human or veterinary use and remain un... |
Risk and Outbreak Communication: Lessons from Taiwan's Experiences in the Post-SARS Era | In addition to the impact of a disease itself, public reaction could be considered another outbreak to be controlled during an epidemic. Taiwan's experience with SARS in 2003 highlighted the critical role played by the media during crisis communication. After the SARS outbreak, Taiwan's Centers for Disease Control (Tai... |
Financial portfolio approach to optimal tourist market mixes | This study applied a financial portfolio theory to estimate optimal market mixes to minimize the instability of inbound tourist market demand. An empirical analysis was applied to inbound tourists to Taiwan. The results shed light on diversification in tourism market and offer tourism authorities and policy-makers expl... |
Tocilizumab for severe COVID-19: a promising intervention affecting inflammation and coagulation | |
Preparedness of Kidney Replacement Therapy in the Critically Ill During COVID-19 Surge | |
Coronavirus ‐ African Situation Report as at March 31st | |
Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: a retrospective study | The Middle East respiratory syndrome coronavirus (MERS-CoV) is a life-threatening respiratory disease with a high case fatality rate; however, its risk factors remain unclear. We aimed to explore the influence of demographic factors, clinical manifestations and underlying comorbidities on mortality in MERS-CoV patients... |
Prise en charge des cancers du sein pendant la pandémie de COVID 19: le CNGOF se mobilise | |
A potential treatment of COVID-19 with TGF-β blockade | |
Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis | We conducted this systemic review and meta‐analysis in an attempt to evaluate the efficacy and safety of umifenovir in coronavirus disease 2019 (COVID‐19). We searched PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and medRxiv database. We included both retrospective and pros... |
Contribution of technical guidance on nosocomial infection control to the containment of Severe Acute Respiratory Syndrome in Vietnam | Abstract When Severe Acute Respiratory Syndrome (SARS) spread in Vietnam in March 2003, Bach Mai Hospital (BMH) contributed greatly to putting SARS under control by conducting strict nosocomial infection control. At BMH, technical guidance on nosocomial infection control had been implemented by Japanese experts since 2... |
CHAPTER 9 Aspects of recent development of immunosensors | Publisher Summary This chapter focuses on the recent developments in the field of immunosensors. Immunosensors incorporate the specific immunochemical reaction with the modern transducers including electrochemical (potentiometric, conductometric, capacitative, impedance, amperometric), optical (fluorescence, luminescen... |
Modeling the structure of SARS 3a transmembrane protein using a minimum unfavorable contact approach | 3a is an accessory protein from SARS coronavirus that is known to play a significant role in the proliferation of the virus by forming tetrameric ion channels. Although the monomeric units are known to consist of three transmembrane (TM) domains, there are no solved structures available for the complete monomer. The pr... |
Dynamic relationship between D‐dimer and COVID‐19 severity | Since December 2019, the seriousness of coronavirus disease 2019 (COVID‐19) pandemic has been on escalation (Lu, et al 2020). Coagulopathy is common in critically ill patients with COVID‐19 (Tang, et al 2020b). Systemic microvascular thrombosismay occur in most deaths, which was further identified by a recent autopsy (... |
Health and Performance of Holstein Calves that Suckled or Were Hand-Fed Colostrum and Were Fed One of Three Physical Forms of Starter 1 | Abstract Intake of colostrum by neonatal calves and early transition to calf starter are two important factors in successful calf programs. Thirty-one Holstein calves were used to determine health and performance of calves that were 1) allowed to remain with their dams for 3 d and suckle (suckled calves) or were remove... |
Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins | Previous findings of Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses in bats, and the ability of Tylonycteris-BatCoV HKU4 spike protein to utilize MERS-CoV receptor, human dipeptidyl peptidase 4 hDPP4, suggest a bat ancestral origin of MERS-CoV. We developed 12 primary bat cell lines from seven ... |
The First Transmembrane Domain of Lipid Phosphatase SAC1 Promotes Golgi Localization | The lipid phosphatase Sac1 cycles between endoplasmic reticulum and cisternal Golgi compartments. In proliferating mammalian cells, a canonical dilysine motif at the C-terminus of Sac1 is required for coatomer complex-I (COP-I)-binding and continuous retrieval to the ER. Starvation triggers accumulation of Sac1 at the ... |
Pandemia de influenza A (H1N1) 2009, 6 meses de experiencia | |
Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target | Cancer cells tend to be more highly dependent on cap‐dependent translation than normal tissues. Thus, proteins involved in the initiation of cap‐dependent translation have emerged as potential anti‐cancer drug targets. Cap‐dependent translation is initiated by the binding of the factor eIF4E to the cap domain of mRNA. ... |
Infectious Diseases | Infectious diseases are caused by infectious organisms. Typically, these are bacteria, … |
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathway | BACKGROUND: The lack of optimal porcine cell lines has severely impeded the study and progress in elucidation of porcine epidemic diarrhea virus (PEDV) pathogenesis. Vero cell, an African green monkey kidney cell line, was often used to isolate and propagate PEDV. Nonetheless, the target cells of PEDV in vivo are intes... |
The Case ∣ Fever, rash, and positive Ehrlichia antibodies | |
Graphene Modified Multifunctional Personal Protective Clothing | Personal protective clothing is intended to protect the wearer from various hazards (mechanical, biological, chemical, thermal, radiological, etc.) and inhospitable environmental conditions that may cause harm or even death. There are various types of personal protective clothing, manufactured with different materials ... |
Commentary: “Preparedness in the Time of COVID”: Implications for Engagement of the Health Care Team with Acute Respiratory Failure | |
Incidence of thrombotic complications in critically ill ICU patients with COVID-19 | Abstract Introduction COVID-19 may predispose to both venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilisation and diffuse intravascular coagulation. Reports on the incidence of thrombotic complications are however not available. Methods We evaluated the incidence of the composite outc... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.