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MY COVID‐19 DIARY | Written in weekly instalments, Michelle Munyikwa's Covid‐19 diary reflects upon the experience of an unfolding pandemic from her dual role as a medical trainee and anthropologist living in the United States. Her observations centre on everyday encounters with scenes or objects that reflect the growing crisis, from the ... |
Epigenetic mechanisms in human adenovirus type 12 oncogenesis | Abstract For the past 30 years, my laboratory has concentrated its work on demonstrating that the epigenetic consequences of foreign DNA insertion into established mammalian genomes – de novo DNA methylation of the integrate and alterations of methylation patterns across the recipient genome – are essential elements in... |
Strain specific antibodies revealed by immunoabsorption studies with avian infectious bronchitis virus | Rabbit antisera prepared against the Massachusetts 41 (M41) strain of avian infectious bronchitis virus (IBV) and absorbed with chick embryo immunoabsorbent produced multiple precipitin lines in immunodouble-diffusion (IDD) tests with homologous or heterologous strains of virus. These precipitin lines were all removed ... |
Biological risk and pollution history of polycyclic aromatic hydrocarbons (PAHs) in Nansha mangrove, South China | Abstract Chinese government has taken various measures to alleviate pollution caused by polycyclic aromatic hydrocarbons (PAHs) in the region of Pearl River Delta since the economic reform in 1978, but the effectiveness of these measures remains largely unknown. This study aimed to elucidate the biological risk and pol... |
Comment je fais: Prise en charge des patients en Radiologie Interventionnelle Oncologique en période de pandémie au SARS-CoV-2 | Résumé Introduction: L’activité d’oncologie en radiologie interventionnelle (RI) doit rester une priorité parmi l’activité de RI en période de pandémie au SARS-CoV-2. Elle doit s’adapter aux ressources anesthésiques et capacité d’hospitalisation des patients. Elle doit assurer la sécurité et la protection des patients ... |
Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic Origins | Identifying molecular targets for eliciting broadly virus-neutralizing antibodies is one of the key steps toward development of vaccines against emerging viral pathogens. Owing to genomic and somatic diversities among viral species, identifying protein targets for broad-spectrum virus neutralization is highly challengi... |
Repurposing current therapeutics for treating COVID‐19: A vital role of prescription records data mining | Since its outbreak in late 2019, the SARS‐Cov‐2 pandemic already infected over 3.7 million people and claimed more than 250,000 lives globally. At least 1 year may take for an approved vaccine to be in place, and meanwhile millions more could be infected, some with fatal outcome. Over thousand clinical trials with COVI... |
Scribes, EHRs, and Workflow Efficiencies in Allergy Practices | PURPOSE OF REVIEW: In the ever-changing healthcare system, along with new advancements in the field of allergy, the workflow for the allergist continues to evolve requiring more time spent doing non-clinical duties such as documentation and reviewing reimbursement challenges in the midst of busy clinics. The use of ele... |
Dynamics of a Cytokine Storm | Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response. Soon after the trial began, each volunteer experienced a “cytokine storm”, a dramatic increase in cytokine concentrations. The monoclonal antibo... |
Special issues raised by evolving areas of clinical research | Each study presents its own set of ethical considerations. Certain kinds of ethical issues are inherent in particular areas of clinical research, regardless of specific ethical questions associated with a specific study. In this chapter, some of the most common special areas of clinical research are presented, highligh... |
COVID-19 Pandemic: Greater Protection for Health Care Providers in the Hospital “Hot Zones”? | |
The basic reproduction number of SARS‐CoV‐2 in Wuhan is about to die out, how about the rest of the World? | The virologically confirmed cases of a new coronavirus disease (COVID‐19) in the world are rapidly increasing, leading epidemiologists and mathematicians to construct transmission models that aim to predict the future course of the current pandemic. The transmissibility of a virus is measured by the basic reproduction ... |
COMPARISON BETWEEN THORACIC RADIOGRAPHIC FINDINGS AND POSTMORTEM DIAGNOSIS OF THORACIC DISEASES IN DYSPNEIC COMPANION RATS (RATTUS NORVEGICUS) | Companion rats are often presented to veterinarians for respiratory difficulties. Dyspnea in rats is most commonly due to infectious pneumonia, and thoracic neoplasia can go undiagnosed ante mortem due to a mistaken interpretation of pneumonia. In domestic carnivores, pulmonary nodular patterns have been shown to corre... |
Etiologie des gastroentérites du nouveau-né au centre hospitalier d'Amiens | Summary An epidemiological study has been carried on at the Amiens' Gynecology-Obstetrical center with the aim to determinate the aetiology of acute gastrointestinal disorders who affected part of the newborns over a two months period. Rotavirus was found in 16 babies (33 %) by electronmicroscopy and Enzyme-linked-Immu... |
It’s F**ing Chaos: COVID-19’s Impact on Juvenile Delinquency and Juvenile Justice | An early examination of the impact of COVID-19 on juvenile delinquency and juvenile justice in America, this review provides initial scholarship to rapidly evolving areas of research. Our appraisals of these topics are made after nearly 2 months of national COVID-19 mitigation measures, like social distancing and limit... |
Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike | Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes angiotensin-converting enzyme 2 (ACE2) as a host protein receptor and mediates fusion of the viral and host membranes, making S essential to vira... |
Interferon Status in Children during Acute Respiratory Infections. Therapy with Interferon | We studied interferon status in children during acute respiratory infections and found that it depends on etiology, course of the disease, and individual features of the organism. The efficiency of IFN inductor anaferon (pediatric formulation) and the possibility of its application in the therapy of children with acute... |
Delivering Benefits at Speed Through Real-World Repurposing of Off-Patent Drugs: The COVID-19 Pandemic as a Case in Point | Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address urgent clinical needs—is a widely overlooked opportunity. Off-label prescribing (ie, for a nonapproved indication) is legal in most countries and tends to shift the burden of liability and cost to physicians and patients, respectively... |
Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children | Acute viral wheeze in children is a major cause of hospitalisation and a major risk factor for the development of asthma. However, the role of the respiratory tract microbiome in the development of acute wheeze is unclear. To investigate whether severe wheezing episodes in children are associated with bacterial dysbios... |
COVID-19: Wissensstand, Risikowahrnehmung und Umgang mit der Pandemie | Zusammenfassung Hintergrund Für den Erfolg der Bemühungen zur Eindämmung einer Epidemie sind die großflächige Umsetzung der Maßnahmen und ihre Akzeptanz in der Bevölkerung wichtig. Diese Studie untersucht daher den Wissensstand und die Risikowahrnehmung in der frühen Phase der COVID-19-Pandemie und analysiert, wie empf... |
Comparative study on the antiviral activity of selected monoterpenes derived from essential oils | Essential oils are complex natural mixtures, their main constituents, e.g. terpenes and phenylpropanoids, being responsible for their biological properties. Essential oils from eucalyptus, tea tree and thyme and their major monoterpene compounds α‐terpinene, γ‐terpinene, α‐pinene, p‐cymene, terpinen‐4‐ol, α‐terpineol, ... |
Re: Testing recommendation for COVID-19 (SARS-CoV-2) in patients planned for surgery - continuing the service and ‘suppressing’ the pandemic | |
Impact of the Interactive e-Learning Instructions on Effectiveness of a Programming Course | The COVID-19 pandemic is forcing schools, universities and learning and development professionals to shift rapidly from in-person to online learning. It made providing of an effective e-learning contents more important. Consequently, the development of e-learning products and provision of e-learning opportunities is on... |
Las revistas científicas ante la pandemia por Covid-19 | |
Comparison of the AnyplexTM II RV16 and Seeplex® RV12 ACE assays for the detection of respiratory viruses | Abstract The AnyplexTM II RV16 detection kit (RV16; Seegene, Seoul, South Korea) is a multiplex real-time PCR assay based on tagging oligonucleotide cleavage extension. In this prospective study, we evaluated the RV16 assay by comparing with the Seeplex® RV12 ACE detection kit (RV12; Seegene), a multiplex end-point PCR... |
Viral infection of the lung: Host response and sequelae | Because of its essential role in gas exchange and oxygen delivery, the lung has evolved a variety of strategies to control inflammation and maintain homeostasis. Invasion of the lung by pathogens (and in some instances exposure to certain noninfectious particulates) disrupts this equilibrium and triggers a cascade of e... |
2019 Novel Coronavirus Disease (COVID‐19) in patients with Inflammatory Bowel Diseases | BACKGROUND: Data on patients with inflammatory bowel diseases (IBD) who have had 2019 novel coronavirus (SARS‐CoV‐2) disease (COVID‐19) are lacking. AIM: To report the clinical characteristics, including gastrointestinal symptoms, of COVID‐19 in IBD patients, and to assess the risk of COVID‐19 in IBD. METHODS: This cas... |
Point prevalence of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma according to the number of cycles of R-CHOP chemotherapy | R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma. We estimated the point prevalence of Pneumocystis pneumonia in non-Hodgkin lymphoma patients according to the number of R-... |
Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis | A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized COVID‐19 patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 20 peer‐reviewed studies meeting criteria for re... |
OL-044 HAV seroprevalence among children with 10 24 month ages in Ulaanbaatar | |
Delivering dialysis during the COVID-19 outbreak: Strategies and outcomes | BACKGROUND: Haemodialysis (HD) patients are at increased risk of COVID-19 infection. Although all dialysis patients meet government criteria for shielding, only those on home treatment can comply. Patients attending incentre HD units represent a large and vulnerable group, who are unable to rigorously adhere to this ad... |
Evaluation of the implementation of occupational health, safety, and environment management systems in higher education laboratories | Laboratory researchers and students may expose to hazardous and toxic chemicals. Implementation of the Occupational Health, Safety, and Environment Management System (OHSEMS) has become a critical aspect in higher education. This study presents an overview of the evaluation of the implementation of the OHSEMS in higher... |
Covid-19 and Optimal Portfolio Selection for Investment in Sustainable Development Goals | The Covid-19 pandemic and global economic recession has shrunk global energy demand and collapsed fossil fuel prices. Therefore, renewable energy projects are losing their competitiveness. This endangers the achievement of several Sustainable Development Goals (SDGs) and the Paris Agreement on Climate Change. Various c... |
Patient pathways of tuberculosis care-seeking and treatment: an individual-level analysis of National Health Insurance data in Taiwan | INTRODUCTION: Patients with tuberculosis (TB) often experience difficulties in accessing diagnosis and treatment. Patient pathway analysis identifies mismatches between TB patient care-seeking patterns and service coverage, but to date, studies have only employed cross-sectional aggregate data. METHODS: We developed an... |
A Survey of COVID-19 Preparedness Among Hospitals in Idaho | BACKGROUND: SARS-CoV-2 has been implicated in the largest recorded coronavirus outbreak to date. Initially, most COVID-19 cases were in China, but the virus has spread to more than 184 countries worldwide, and the United States currently has more cases than any other country. OBJECTIVE: With person-to-person spread exp... |
The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol | BACKGROUND: There is a worldwide outbreak of covid-19, and as the number of patients increases, more and more patients are recovering. Massage is used as an alternative therapy. Currently, there are no relevant articles for systematic review. METHODS: We will search the randomized controlled trials related to acupunctu... |
Rotavirus typing methods and algorithms | Vaccination is the current strategy for control and prevention of severe rotavirus infections, a major cause of acute, dehydrating diarrhoea in young children worldwide. Public health interventions aimed at improving water, food and sanitation are unlikely adequately to control the disease. The development of vaccines ... |
Electronic Personal Protective Equipment: A Strategy to Protect Emergency Department Providers in the Age of COVID-19 | Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. W... |
The Timing and Nature of Behavioural Responses Affect the Course of an Epidemic | During an epidemic, the interplay of disease and opinion dynamics can lead to outcomes that are different from those predicted based on disease dynamics alone. Opinions and the behaviours they elicit are complex, so modelling them requires a measure of abstraction and simplification. Here, we develop a differential equ... |
The ‘Black Death’ and the physician at the time of COVID-19 | |
Clinical characteristics and factors predicting respiratory failure in adenovirus pneumonia | BACKGROUND AND OBJECTIVE: Limited data exist regarding factors predicting respiratory failure (RF) in non‐immunocompromised patients with adenovirus (AdV) pneumonia. METHODS: We described characteristics of AdV pneumonia (n = 91) versus non‐AdV pneumonia (n = 55) and compared clinico‐laboratory and radiological charact... |
Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach | As the COVID-19 pandemic progressed across the world, governments, international agencies, policymakers, and public health officials began recommending widespread use of nonmedical cloth masks to reduce the transmission of SARS-CoV-2. The authors of this article suggest that there is convincing evidence to support this... |
A Novel Antiviral Strategy against MERS-CoV and HCoV-229E Using Binase to Target Viral Genome Replication | RNA viruses cause most of the dangerous communicable diseases. Due to their high mutation rates, RNA viruses quickly evade selective pressures and can adapt to a new host. Therefore, new antiviral approaches are urgently needed, which target more than one specific virus variant and which would optimally prevent develop... |
The science commons in health research: structure, function, and value | The “science commons,” knowledge that is widely accessible at low or no cost, is a uniquely important input to scientific advance and cumulative technological innovation. It is primarily, although not exclusively, funded by government and nonprofit sources. Much of it is produced at academic research centers, although ... |
Department of Homeland Security national planning scenarios: a spectrum of imaging findings to educate the radiologists | Following the events of the September 11th attack, there has been an increasing concern about the possibility of a future attack on our homeland. In response, the United States Department of Homeland Defense has planned for a future attack by formulating multiple scenarios which may occur in the event of such a disaste... |
Prioritization of Zoonotic Diseases in Kenya, 2015 | INTRODUCTION: Zoonotic diseases have varying public health burden and socio-economic impact across time and geographical settings making their prioritization for prevention and control important at the national level. We conducted systematic prioritization of zoonotic diseases and developed a ranked list of these disea... |
Therapy for probable COVID‐19 associated erythema pernio‐like lesions in pediatric age. Case report | |
VI, 1. Epidemiology of toroviruses | Publisher Summary The discovery of the toroviruses, which comprise a genus of the family Coronaviridae, began with the serendipitous isolation of the morphologically unique Berne virus (ETV) in feces of a horse. This chapter discusses the epidemiology of toroviruses. ETV was first detected by the isolation of the virus... |
Dwindling blood reserves: An ominous downside of COVID-19 pandemic | • Transfusion therapy is vital to ensure a healthy community. Thus, a safe and reliable reserve of blood is necessary, even in the face of widespread illness. • Since the outbreak of the novel coronavirus, a decline in blood supply has been noticed as hospitals and communities have switched to more pandemic-oriented op... |
Computer Vision Toolkit for Non-invasive Monitoring of Factory Floor Artifacts | Abstract Digitization has led to smart, connected technologies be an integral part of businesses, governments and communities. For manufacturing digitization, there has been active research and development with a focus on Cloud Manufacturing (CM) and the Industrial Internet of Things (IIoT). This work presents a comput... |
Repeat Auditing of Primary Health-care Facilities Against Standards for Occupational Health and Infection Control: A Study of Compliance and Reliability | BACKGROUND: The elevated risk of occupational infection such as tuberculosis among health workers in many countries raises the question of whether the quality of occupational health and safety (OHS) and infection prevention and control (IPC) can be improved by auditing. The objectives of this study were to measure (1) ... |
Preparing for a COVID-19 surge | |
Personalized Nutrition and -Omics | With change in global concern toward food quality over food quantity, consumer concern and choice of healthy food has become a matter of prime importance. It gave rise to concept of “personalized or precision nutrition”. The theory behind personalization of nutrition is supported by multiple factors including advances ... |
Suspension of ulipristal acetate for uterine fibroids during ongoing EMA’s review of liver injury risk: Unfortunate timing during the Covid-19 pandemic! | OBJECTIVE: EMA decided that with ulipristal acetate (UPA) treatment for uterine fibroids, should be discontinued due to the associated risk of hepatic failure, We analyzed whether the risk of recurrent symptoms due to fibroids may lead to an increased risk of Covid -19 infection and death, that would exceed the former ... |
System pharmacogenomics application in infectious diseases | The new era in systems pharmacology has revolutionized the human biology. Its applicability, precise treatment, adequate response and safety measures fit into all the paradigm of medical/clinical practice. The importance of mathematical models in understanding the disease pathology and epideomology is now being realize... |
Psychosis spectrum disorders during and after the COVID-19 pandemic: Warning signs of “stress incubation” | |
A herbal formula for prevention of influenza-like syndrome: A double-blind randomized clinical trial | OBJECTIVE: To investigate the efficacy of a herbal formula in the prevention of influenza or influenza-like syndrome among elderies residing in old-people’s home in Hong Kong. The secondary objectives are to investigate the quality of life (QOL) and symptomology changes among the herbal users and to evaluate the safety... |
The U.S. Health Care System on the Eve of the Covid-19 Epidemic: A Summary of Recent Evidence on Its Impaired Performance | Four decades of neoliberal health policies have left the United States with a health care system that prioritizes the profits of large corporate actors, denies needed care to tens of millions, is extraordinarily fragmented and inefficient, and was ill prepared to address the COVID-19 pandemic. The payment system has lo... |
Longitudinal analyses of the relationship between development density and the COVID-19 morbidity and mortality rates: Early evidence from 1,165 metropolitan counties in the United States | This longitudinal study aimed to investigative the impacts of development density on the spread and mortality rates of COVID-19 in metropolitan counties in the United States. Multilevel Linear Modeling (MLM) were employed to model the infection rate and the mortality rate of COVID-19, accounting for the hierarchical (t... |
Utilización adecuada del lenguaje médico: principales problemas y soluciones | Resumen El lenguaje médico debe caracterizarse por su precisión, neutralidad emocional y estabilidad. La comunicación efectiva de los resultados de los trabajos científicos depende del cumplimiento de las normas vigentes de redacción y estilo, de manera que en un texto con defectos formales puede quedar mermado el inte... |
Enterohaemorrhagic Escherichia coli: A new problem, an old group of organisms Inter faeces et urinam nascimur | All mammals are colonised by Escherichia coli generally at birth and these organisms become part of their intestinal flora for the rest of their lives. New types are acquired generally by an oral route. Some E coli are pathogenic and some may have a far more enhanced ability to colonise the human intestine than most ot... |
Neuropsychiatric aspects of COVID-19 Pandemic: A Selective Review | Corona virus disease (COVID-19) has been declared as a controllable pandemic by the World Health Organization (WHO). COVID-19 though is a predominantly respiratory illness; it can also affect brain and other organs like kidneys, heart and liver. Neuropsychiatric manifestations are common during viral pandemics but are ... |
Suitability evaluation on material specifications and edible methods of Dendrobii Officinalis Caulis based on holistic polysaccharide marker | Background: Dendrobii Officinalis Caulis (DC) is a well-known tonic herbal medicine worldwide and has favorable immunomodulatory activity. Various material specifications of DC are available in herbal markets, and DC is ingested by different edible methods. However, whether these specifications and edible methods are s... |
Update on bacterial pathogens: virulence and resistance | The present article is an update of the literature on bacterial pathogens. Recognizing the interest and scientific and public health importance of infections produced by bacterial pathogens with new virulence mechanisms and/or new mechanisms of resistance to antimicrobial agents, a multidisciplinary group of Spanish ph... |
The Nucleocapsid Protein of Human Coronavirus NL63 | Human coronavirus (HCoV) NL63 was first described in 2004 and is associated with respiratory tract disease of varying severity. At the genetic and structural level, HCoV-NL63 is similar to other members of the Coronavirinae subfamily, especially human coronavirus 229E (HCoV-229E). Detailed analysis, however, reveals se... |
Role of viral coinfections in asthma development | BACKGROUND: Viral respiratory infections, especially acute bronchiolitis, play a key role in the development of asthma in childhood. However, most studies have focused on respiratory syncytial virus or rhinovirus infections and none of them have compared the long-term evolution of single versus double or multiple viral... |
Obesity and COVID‐19: an Italian snapshot | OBJECTIVE: The clinical manifestations of COVID‐19 run from asymptomatic disease to severe acute respiratory syndrome. Older age and comorbidities are associated to more severe disease. A role of obesity is suspected. METHODS: We enrolled patients hospitalized in the medical COVID‐19 ward with SARS‐CoV‐2 related pneumo... |
Synthetic Biology and Personalized Medicine | Synthetic biology, application of synthetic chemistry to biology, is a broad term that covers the engineering of biological systems with structures and functions not found in nature to process information, manipulate chemicals, produce energy, maintain cell environment and enhance human health. Synthetic biology device... |
The Role of Medical Students During the COVID-19 Pandemic | In this commentary, the authors discuss multiple potential clinical roles for medical students during the coronavirus disease 2019 pandemic. |
The early immune response to infection of chickens with Infectious Bronchitis Virus (IBV) in susceptible and resistant birds | BACKGROUND: Infectious Bronchitis is a highly contagious respiratory disease which causes tracheal lesions and also affects the reproductive tract and is responsible for large economic losses to the poultry industry every year. This is due to both mortality (either directly provoked by IBV itself or due to subsequent b... |
Effectiveness of N95 respirators versus surgical masks against influenza: A systematic review and meta‐analysis | OBJECTIVE: Previous meta‐analyses concluded that there was insufficient evidence to determine the effect of N95 respirators. We aimed to assess the effectiveness of N95 respirators versus surgical masks for prevention of influenza by collecting randomized controlled trials (RCTs). METHODS: We searched PubMed, EMbase an... |
Everything old is new again: COVID-19 and public health | |
Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces | Abstract Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens. The antibodies were characterized by neutralization test, hemagglutination inhibition test, enzyme-linked immunosorben... |
A high-throughput approach to profile RNA structure | Here we introduce the Computational Recognition of Secondary Structure (CROSS) method to calculate the structural profile of an RNA sequence (single- or double-stranded state) at single-nucleotide resolution and without sequence length restrictions. We trained CROSS using data from high-throughput experiments such as S... |
Personal Protective Equipment (PPE) and Its Use in COVID-19: Important Facts | |
Iranian healthcare system against COVID-19 | |
Anticoagulation, Immortality, and Observations of COVID‐19 | The current coronavirus disease 2019 (COVID‐19) pandemic has produced an understandable sense of urgency among clinicians and researchers to develop, deploy, and report novel treatment strategies. Many centers are therefore using off‐label therapies and reporting early observational results of their experiences.(1‐3) A... |
Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein | Middle East respiratory syndrome (MERS) coronavirus (Co-V) contains a single spike (S) protein, which binds to a receptor molecule, dipeptidyl peptidase 4 (DPP4; also known as CD26), and serves as a neutralizing antigen. Pseudotyped viruses are useful for measuring neutralization titers against highly infectious viruse... |
Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae | Since the end of 2019, the global COVID-19 outbreak has once again made coronaviruses a hot topic. Vaccines are hoped to be an effective way to stop the spread of the virus. However, there are no clinically approved vaccines available for coronavirus infections. Reverse genetics technology can realize the operation of ... |
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases | The study of antiviral pathways to reveal methods for the effective response and clearance of virus is closely related to understanding interferon (IFN) signaling and its downstream target genes, IFN-stimulated genes. One of the key antiviral factors induced by IFNs, 2′-5′ oligoadenylate synthase (OAS), is a well-known... |
Respiratory Syncytial Virus Outbreak in a Long‐Term Care Facility Detected Using Reverse Transcriptase Polymerase Chain Reaction: An Argument for Real‐Time Detection Methods | OBJECTIVES: To report an outbreak of respiratory synctyial virus (RSV) in a long‐term care facility (LTCF) during ongoing routine respiratory illness surveillance. DESIGN: Rapid antigen testing, viral culture, direct fluorescent antibody (DFA) testing, and reverse transcriptase polymerase chain reaction (RT‐PCR) testin... |
Night Sky Brightness Monitoring Network in Wuxi, China | The rapid development of cities has brought tremendous pressure to astronomical observation, energy security, and the ecosystem. Automatic monitoring of night sky brightness (NSB) can help us to understand its regional differences and time variations of NSB effectively and to investigate the human and natural factors w... |
Risk of COVID-19 in patients treated for cancer: an immune response-based hypothesis | |
Numerical investigation of gaseous pollutant cross-transmission for single-sided natural ventilation driven by buoyancy and wind | Abstract Single-sided natural ventilation was numerically investigated to determine the impact of buoyancy and wind on the cross-transmission of pollution by considering six window types commonly found in multistory buildings. The goal of this study was to predict the gaseous pollutant transmission using computational ... |
Emergence of COVID-19 Infection: What Is Known and What Is to Be Expected-Narrative Review Article | BACKGROUND: The discovery of the coronavirus disease 2019 (COVID-19) during a pneumonia outbreak in Wuhan city (China) has raised a global public health concern, as the city consists of around 11 million people and is considered a major transport and logistics hub. This deadly virus caused the world to be in high alert... |
Thin-section Computed Tomography Detects Long-term Pulmonary Sequelae 3 Years after Novel Influenza A Virus-associated Pneumonia | BACKGROUND: The aim of this research was to evaluate long-term pulmonary sequelae on paired inspiration-expiration thin-section computed tomography (CT) scans 3 years after influenza A (H1N1) virus-associated pneumonia, and to analyze the affecting factors on pulmonary fibrosis. METHODS: Twenty-four patients hospitaliz... |
Investigation of the performance of TiO2 photocatalytic coatings | Abstract TiO2 photocatalysts were prepared and coated on surfaces. Ultrathin TiO2 coatings were obtained by wash-coating and screen-printing techniques. The latter provides films of excellent adhesion that could tolerate washing under water jet. The scratch-proof coatings were characterized, and X-ray diffraction (XRD)... |
Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection | Summary The COVID-19 pandemic is an unprecedented global challenge and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high throughput serum and plasma proteomics that builds on ISO13485 standardisation and high-flow liquid chromatography to facilitate implementation in... |
Spatiotemporal distribution of a non-haematophagous bat community and rabies virus circulation: a proposal for urban rabies surveillance in Brazil | In Brazil, rabies surveillance is based on monitoring domestic and wild animals, although the most prevalent lineage of the rabies virus (RABV) currently diagnosed in Brazil is associated with bats, particularly non-haematophagous bats. Disease control is based on the mass vaccination of dogs and cats. We used data col... |
Granulomatous peritonitis and pleuritis in interferon‐γ gene knockout mice naturally infected with mouse hepatitis virus | Objective To investigate a disease outbreak in a colony of laboratory mice with targeted disruption of the gene for interferon‐γ FORMAT: A case report based on necropsy, histopathology, serology and immunohistochemistry. RESULTS: Affected mice exhibited depression and variable ascites. Necropsy revealed a granulomatous... |
Bat super immunity to lethal disease could help protect people | |
The psychology behind the masks: Psychological responses to the severe acute respiratory syndrome outbreak in different regions | Severe acute respiratory syndrome (SARS) was first reported in China, and spread to 29 regions, affecting over 8000 people worldwide. For the general public, the psychological impact of SARS may have been greater than the physical health danger of the disease. The present paper proposes the influence of psychological f... |
A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection | BACKGROUND: Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animals and humans. There are no approved vaccines or treatments for use in humans; however, therapeutic treatment of both NiV and HeV infection in ferrets and nonhuman primates with a cross-reactive, neu... |
561. Recombinant Adenovirus Carrying Spike Gene Induces Effective Humoral and Cellular Immunity Against SARS-CoV in Rats | |
Identification and Characterization of a Human Coronavirus 229E Nonstructural Protein 8-Associated RNA 3′-Terminal Adenylyltransferase Activity | Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and found that the protein has metal ion-dependent RNA 3′-terminal adenylylt... |
Prevention and control measures in radiology department for COVID-19 | ABSTRACT: Since a novel coronavirus was discovered from a cluster of patients with emerging pneumonia of unknown etiology in Wuhan, China, it has spread rapidly through droplet and contact transmission. Recently, the novel coronavirus pneumonia which was named COVID-19 by the World Health Organization (WHO) has been ra... |
Viral Pneumonia Requiring Differentiation from Acute and Progressive Diffuse Interstitial Lung Diseases | OBJECTIVE: The clinical characteristics and chest imaging findings of viral pneumonia and several interstitial lung diseases (ILDs) overlap, and viral pneumonia may be underrecognized and misdiagnosed as certain ILDs. To clarify the frequency of viral pneumonia among patients with acute progressive clinical courses tha... |
Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam | In January 2020, we identified two SARS‐CoV‐2 infections in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS‐CoV‐2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human‐to‐human t... |
The Third and Fatal Shock: How Pandemic Killed the Millennial Paradigm | This millennium began with widespread acceptance of a governing paradigm emphasizing small government, free markets and open borders. Three crises – the 9/11 attacks, the 2008 financial crisis, and the 2020 COVID‐19 pandemic – forced American policymakers to diverge from this paradigm. At the time, these divergences we... |
Hepatitis Relapse after Yellow Fever Infection: Is There Another Wave? | During the yellow fever (YF) outbreak in Brazil, many cases of fulminant hepatitis were seen, although mild to moderate hepatitis was mostly observed with complete recovery. This report presents a case of late-onset hepatitis due to YF relapse. The patient sought medical attention after jaundice recurrence 40 days afte... |
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