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The Urgency of Care during the Covid-19 Pandemic — Learning as We Go | |
Blockchain and Artificial Intelligence Technology for Novel Coronavirus Disease 2019 Self-Testing | The novel coronavirus disease 2019 (COVID-19) is rapidly spreading with a rising death toll and transmission rate reported in high income countries rather than in low income countries. The overburdened healthcare systems and poor disease surveillance systems in resource-limited settings may struggle to cope with this C... |
Cryptosporidium parvum and Giardia intestinalis in Calf Diarrhoea in Sweden | The objective of this study conducted in 75 herds was to investigate the presence and significance of Cryptosporidium parvum and Giardia intestinalis in Swedish dairy calves in comparison with rotavirus, coronavirus and Escherichia coli K99+. The farmers were asked to collect faecal samples from each heifer calf that h... |
Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation | The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the pulmonary myocardium gains pacemaker function is not clearly defined, a... |
The Supramap project: linking pathogen genomes with geography to fight emergent infectious diseases | Novel pathogens have the potential to become critical issues of national security, public health and economic welfare. As demonstrated by the response to Severe Acute Respiratory Syndrome (SARS) and influenza, genomic sequencing has become an important method for diagnosing agents of infectious disease. Despite the val... |
Using Clinicians’ Search Query Data to Monitor Influenza Epidemics | Search query information from a clinician's database, UpToDate, is shown to predict influenza epidemics in the United States in a timely manner. Our results show that digital disease surveillance tools based on experts' databases may be able to provide an alternative, reliable, and stable signal for accurate prediction... |
A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention | PURPOSE OF REVIEW: An unexpected and sudden outbreak of a novel infection known as a coronavirus (COVID-19) has imposed important problems to global well-being and economy. Based upon current researches, this virus is spreading from one human to another through respiratory droplets, i.e. cough and sneeze. Till now, the... |
Anti-SARS drug screening by molecular docking | Starting from a collection of 1386 druggable compounds obtained from the 3D pharmacophore search, we performed a similarity search to narrow down the scope of docking studies. The template molecule is KZ7088 (Chou et al., 2003, Biochem Biophys Res Commun 308: 148–151). The MDL MACCS keys were used to fingerprint the mo... |
Rapid Synthesis of Iminosugar Derivatives for Cell‐Based In Situ Screening: Discovery of “Hit” Compounds with Anticancer Activity | Effective and efficacious drug screening methods are imperative in the drug discovery process. A library has been constructed efficiently and followed by in situ cell‐based screening without product purification. This method led to discovery of several iminosugar derivatives with anticancer activity.[Image: see text] |
Hot topics en infecciones respiratorias | Resumen Revisión crítica de los artículos sobre infecciones respiratorias publicados en el último trimestre de 2008 y el presente año. En los pacientes con bronquiectasias destacan artículos que estudian su calidad de vida, así como los que analizan la disminución del número de exacerbaciones por el efecto inmunomodula... |
Pandemic brings accessible mental health care to rural Texas | The COVID‐19 pandemic has created widespread fear and economic anxiety across Texas, and mental health experts and advocates say rural areas — which already had fewer providers and higher rates of suicide and drug overdoses — could see more severe mental health impacts than the state's urban areas. They are predicting ... |
Intervention Protocol of the Orthopedics and Traumatology Department of a High-Complexity University Hospital to Cope with the COVID-19 Pandemic | Objective To describe the protocols implemented to adapt the orthopedic team to the COVID-19 pandemic; a secondary objective is to assess the behavior of hospital and departmental variables when implementing such measures. Methods The present is a retrospective study describing three protocols: 1) reduction in the risk... |
Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain | The key enzyme in coronavirus polyprotein processing is the viral main proteinase, M(pro), a protein with extremely low sequence similarity to other viral and cellular proteinases. Here, the crystal structure of the 33.1 kDa transmissible gastroenteritis (corona)virus M(pro) is reported. The structure was refined to 1.... |
Detection, sequence analysis, and antibody prevalence of porcine deltacoronavirus in Taiwan | Porcine deltacoronavirus (PDCoV) was initially documented in Hong Kong and later in the United States, South Korea, and Thailand. To investigate if PDCoV is also present in Taiwan, three swine coronaviruses—PDCoV, porcine epidemic diarrhea virus (PEDV), and transmissible gastroenteritis coronavirus (TGEV)—were tested u... |
Nitazoxanide May Modify the Course of Progressive Multifocal Leukoencephalopathy | |
Dealing with bio- and ecological complexity: Challenges and opportunities | Abstract The complexities of the dynamic processes and their control associated with biological and ecological systems offer many challenges for the control engineer. Over the past decades the application of dynamic modelling and control has aided understanding of their complexities. At the same time using such complex... |
Physics in a time of COVID-19 | As the number of COVID-19 cases continues to grow around the world, physicists — many of whom rely on international travel and collaborations — are adapting. |
“Optimization of Surgical Resident Safety and Education During the COVID-19 Pandemic - Lessons Learned“ | The COVID-19 pandemic has engendered rapid and significant changes in clinical patient care. Within the realm of surgical training, the resultant reduction in clinical exposure and case volume jeopardizes the quality of surgical training. Thus, our general surgery residency program proceeded to develop a tailored appro... |
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection | Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK ce... |
Antiviral activity of a Bacillus sp. P34 peptide against pathogenic viruses of domestic animals | P34 is an antimicrobial peptide produced by a Bacillus sp. strain isolated from the intestinal contents of a fish in the Brazilian Amazon basin with reported antibacterial activity. The aim of this work was to evaluate the peptide P34 for its in vitro antiviral properties against canine adenovirus type 2 (CAV-2), canin... |
Guidelines for vaccination of dogs and cats in Korea | This guideline contains the recommended vaccination schedules of dogs and cats from World Small Animal Veterinary Association (WSAVA) and American Animal Hospital Association (AAHA). In 2010, WSAVA published guidelines for the vaccination of dogs and cats. And, in 2011, AAHA also published guidelines for vaccination of... |
Transmission and evolutionary dynamics of human coronavirus OC43 strains in coastal Kenya investigated by partial spike sequence analysis, 2015–16 | Human coronavirus OC43 (HCoV-OC43) is a major contributor to seasonal outbreaks of acute respiratory illness (ARI). The origins of locally circulating HCoV-OC43 strains and characteristics of their genetic diversity are unknown for most settings despite significance to effective HCoV control strategies. Between Decembe... |
A review of modern technologies for tackling COVID-19 pandemic | Abstract Objective Science and technology sector constituting of data science, machine learning and artificial intelligence are contributing towards COVID-19. The aim of the present study is to discuss the various aspects of modern technology used to fight against COVID-19 crisis at different scales, including medical ... |
Student placement adaptability during COVID‐19: Lessons learnt in 2020 | |
Acute Liver Injury in COVID‐19: Prevalence and Association with Clinical Outcomes in a Large US Cohort | BACKGROUND & AIMS: Coronavirus disease 2019 (COVID‐19) has been associated with acute liver injury manifested by increased liver enzymes in reports worldwide. Prevalence of liver injury and associated clinical characteristics are not well‐defined. We aim to identify the prevalence of and risk factors for development of... |
Ebola: A Hyperinflated Emergency | As with the Ebola outbreak, global under-5 mortality and morbidity should be considered a public health emergency of international concern. |
The impact of the International Atomic Energy Agency (IAEA) program on radiation and tissue banking in Indonesia | In 1986, the National Nuclear Energy Agency (Batan) in Jakarta started the research and development for the setting up of a tissue bank (Batan Research Tissue Bank/BRTB) by preserving fresh amnion or fetal membranes by lyophilisation and then sterilising by gamma irradiation. During the period of 1990 and 2000, three m... |
Pathogenic viruses: Molecular detection and characterization | Abstract Pathogenic viruses are viruses that can infect and replicate within human cells and cause diseases. The continuous emergence and re-emergence of pathogenic viruses has become a major threat to public health. Whenever pathogenic viruses emerge, their rapid detection is critical to enable implementation of speci... |
Inhibitory effect of sodium houttuyfonate on synovial proliferation in vitro in cells from a patient with rheumatoid arthritis | The aim of the present study was to investigate the inhibitory effect of sodium houttuyfonate (SH) on synovial cell proliferation in vitro. Primary cells were obtained from the synovial tissue of a patient with rheumatoid arthritis (RA). The cells were divided into five treatment groups as follows: the control group (g... |
Genomic characterization and pathogenicity of a porcine hemagglutinating encephalomyelitis virus strain isolated in China | Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the genus betacoronavirus within the family coronaviridae, which invades the central nervous system (CNS) via peripheral nervous system and causes encephalomyelitis or vomiting and wasting disease (VWD) in sucking piglets. Up to now, although few co... |
Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification | |
Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases | Health can be defined as a harmony, or homeostasis, of the activities of thousands of different proteins, whereas aging and diseases result from their disharmony manifested at the levels of cells and tissues. Such disharmony is caused primarily by dysfunction and toxicity of misfolded proteins damaged by oxidation. Thi... |
Pulmonary Histoplasma Infection After Allogeneic Hematopoietic Stem Cell Transplantation: Case Report and Review of the Literature | Histoplasmosis causes a wide spectrum of clinical illness, including disseminated infection in the immunocompromised. We report a case of pulmonary histoplasmosis in an allogeneic stem cell transplant recipient and review the literature on this topic. Histoplasmosis in this patient population is uncommon, but it is ass... |
Coronavirus Spike Protein Inhibits Host Cell Translation by Interaction with eIF3f | In response to viral infection, the expression of numerous host genes, including predominantly a number of proinflammatory cytokines and chemokines, is usually up-regulated at both transcriptional and translational levels. It was noted that in cells infected with coronavirus, transcription and translation of some of th... |
COVID-19—immunity from prosecution for physicians forced to allocate scarce resources: the Italian perspective | |
Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances | Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV researc... |
Growth Performance and Health of Dairy Calves Bedded with Different Types of Materials | Abstract Granite fines, sand, rice hulls, long wheat straw, and wood shavings were compared as bedding for 60 female dairy calves. Growth, health, stress indices, and behavior of newly born calves, along with physical characteristics and bacterial counts of bedding, were evaluated for 42 d during August to October, 200... |
A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019 | Coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus 2 has become an important public health issue in the world. More than 118 000 cases were confirmed around the world. The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms. Howeve... |
Letter to the Editor: A Response to the Comments of Borderas et al. (2007) | |
The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor | The virus family Flaviviridae encompasses several viruses, including (re)emerging viruses which cause widespread morbidity and mortality throughout the world. Members of this virus family are positive-strand RNA viruses and replicate their genome in close association with reorganized intracellular host cell membrane co... |
Réplica: Ivermectina en COVID-19. ¿Argumentum ad ignorantiam? | |
Diversity in the Enteric Viruses Detected in Outbreaks of Gastroenteritis from Mumbai, Western India | Faecal specimens collected from two outbreaks of acute gastroenteritis that occurred in southern Mumbai, India in March and October, 2006 were tested for seven different enteric viruses. Among the 218 specimens tested, 95 (43.6%) were positive, 73 (76.8%) for a single virus and 22 (23.2%) for multiple viruses. Single v... |
Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients | |
Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander | BACKGROUND: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. METHODS: From September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecula... |
Development of a semi-structured, multifaceted, computer-aided questionnaire for outbreak investigation: e-Outbreak Platform | BACKGROUND: Aggressive tracing of contacts of confirmed cases is crucial to Taiwan’s successful control of the early spread of COVID-19. As the pandemic lingers, an epidemiological investigation that can be conducted efficiently in a timely manner can help decrease the burden on the health personnel and increase the us... |
Glass fragment injury to the craniocervical junction with inter-atlanto-occipital penetration to the subarachnoid space: Not-to-be-missed important aspects of craniocervical trauma even in the middle of the COVID-19 pandemic: a case report with a review of the literature | Abstract Background Non-missile penetrating injuries to the craniocervical junction caused by a glass fragment are rare, and a standard management strategy has not been established. Case Description A 75-year-old Japanese man was brought into our emergency department after receiving a left retroauricular stab wound by ... |
Toux chronique de l’enfant | Résumé Introduction La toux chronique de l’enfant bien que moins fréquente que les toux répétées liées aux infections virales reste un problème diagnostique parfois difficile à résoudre. États des connaissances La majorité des auteurs estiment que sa durée doit être supérieure à trois semaines. Peu d’études ont été con... |
Emergency ophthalmic surgeries during COVID-19—a Hong Kong perspective | |
Serum Procalcitonin Measurement and Viral Testing to Guide Antibiotic Use for Respiratory Infections in Hospitalized Adults: A Randomized Controlled Trial | Background. Viral lower respiratory tract illness (LRTI) frequently causes adult hospitalization and is linked to antibiotic overuse. European studies suggest that the serum procalcitonin (PCT) level may be used to guide antibiotic therapy. We conducted a trial assessing the feasibility of using PCT algorithms with vir... |
Induction of labor and risk of third- and fourth-degree perineal tears | Objectives The rate of induction of labor (IOL) at term has been increasing over the years. Our objective was to evaluate the risk of third- and fourth-degree perineal tears associated with term induction of labor. This section of the Journal of Obstetrics and Gynaecology Canada contains the oral, poster, and video abs... |
Marketization vs. market chase: Insights from implicit government guarantees | Abstract Local Government Financing Vehicles (LGFVs) and state-owned enterprises (SOEs) provide implicit guarantee during the issuing of bonds, thereby reducing their funding cost. The credit spreads are lower when issued by a LGFV with a higher administrative level. This means that implicit guarantee is also strengthe... |
Filoviruses in Bats: Current Knowledge and Future Directions | Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and ecology remained elusive until recent studies linked them through... |
Cardiology Practice and Training Post-COVID-19: Achieving “Normalcy” After Disruption | |
Chapter 7 Detection and Diagnosis of Viral Infections | Abstract Diagnostic tests are paramount in determining the etiology of viral infections. Direct diagnostic methods assay for the presence of the virus, while indirect methods test for effects of the virus. Cell culture is the process of growing cells or tissues in the laboratory. Cell lines can be infected with patient... |
Ocular symptoms among non-hospitalized patients who underwent COVID-19 testing | |
The Importance of Understanding the Human–Animal Interface: From Early Hominins to Global Citizens | The complex relationships between the human and animal species have never ceased to evolve since the emergence of the human species and have resulted in a human–animal interface that has promoted the cross-species transmission, emergence and eventual evolution of a plethora of infectious pathogens. Remarkably, most of ... |
Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse | SUMMARY The French public health institute is responsible for promoting and coordinating threats the detection and assessment of health risks, and for suggesting possible responses. Transmissible diseases affecting both human and animal health are the focus of surveillance networks. Early detection of potential infecti... |
Covido‐pedago‐phobia | Breathlessness, aches and pains, abdominal discomfort and hoarse voice! These may sound like the clinical presentation of COVID‐19, but Nay! These are the symptoms experienced by the countless health professions education (HPE) teachers who have suddenly been thrust into the online world to engage learners. |
SARS-CoV-2 Detection in Different Respiratory Sites: A Systematic Review and Meta-Analysis | Background: The accurate detection of SARS-CoV-2 through respiratory sampling is critical for the prevention of further transmission and the timely initiation of treatment for COVID-19. There is a diverse range of SARS-CoV-2 detection rates in reported studies, with uncertainty as to the optimal sampling strategy for C... |
Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19 | Severe respiratory consequences of the COVID-19 pandemic have prompted urgent need for novel therapies. Cell-based approaches, primarily using mesenchymal stem (stromal) cells (MSCs), have demonstrated safety and possible efficacy in patients with the acute respiratory distress syndrome (ARDS), although not as yet well... |
The next protein transition | Abstract Background Meeting the UN Sustainable Development Goals requires a relatively rapid transition towards a circular economy. Therefore, a multidisciplinary perspective is required to sketch why a transition from diets based primarily on animal proteins towards diets based primarily on plant proteins products is ... |
Chapter 29 Design of Genomic Signatures for Pathogen Identification and Characterization | Publisher Summary This chapter addresses issues associated with the identification of signatures based on genomic DNA/RNA, which can be used to identify and characterize pathogens for biodefense and microbial forensic goals. Genomic signature-based identification techniques have the advantage of being precise, highly s... |
Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure | Evolution of H1N1 influenza A outbreaks of the past 100 years is interesting and significantly complex and details of H1N1 genetic drift remains unknown. Here we investigated the clinical characteristics and immune cross-reactivity of significant historical H1N1 strains. We infected ferrets with H1N1 strains from 1943,... |
Chapter 11 Response at the State and Local Level | Abstract Chapter 11 covers the convergence of agencies from all levels of government to the scene of a biological event. In fact, many agencies from the federal level will respond to a chemical, biological, radiological/nuclear, and explosive incident, providing necessary resources. Planners within local jurisdictions ... |
COVID-19 outbreak in France: Setup and activities of a mobile Extra Corporeal Membrane Oxygenation (ECMO) team during the first 3 weeks | |
Clinical Decision Support Tool and Rapid Point-of-Care Platform for Determining Disease Severity in Patients with COVID-19 | SARS-CoV-2 is the virus that causes coronavirus disease (COVID-19) which has reached pandemic levels resulting in significant morbidity and mortality affecting every inhabited continent. The large number of patients requiring intensive care threatens to overwhelm healthcare systems globally. Likewise, there is a compel... |
Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena | Porcine reproductive and respiratory syndrome virus (PRRSV) plays a key role in porcine respiratory disease complex modulating the host immune response and favouring secondary bacterial infections. Pulmonary alveolar macrophages (PAMs) are the main cells supporting PRRSV replication, with CD163 as the essential recepto... |
Chapter 48 Mucosal Vaccine Development for Veterinary and Aquatic Diseases | Abstract Because most pathogens and food antigens enter the host via the mucosal surfaces, effective mucosal immunity is critical for maintaining homeostasis through immune regulation, tolerance, and induction of effective immune responses when needed. Thus the mucosa-associated lymphoid tissues represent an important ... |
The Views of Medical Faculty Students in Turkey Concerning the COVID-19 Pandemic | The aim of this study was to elicit the views of medical faculty students regarding the COVID-19 pandemic. This descriptive study was performed with Ondokuz Mayıs University Medical Faculty students on 24–27 March, 2020. The Medical Faculty currently has 2051 students. A questionnaire was used as a data collection tool... |
Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health | Human milk oligosaccharides (HMO) are complex sugars which are found in breast milk at significant concentrations and with unique structural diversity. These sugars are the fourth most abundant component of human milk after water, lipids, and lactose and yet provide no direct nutritional value to the infant. Recent res... |
Le silence des questions sur la mort des aînés liée au Covid19 | |
Is investing in religious institutions a viable pathway to reduce mortality in the population? | There is established and consistent findings from epidemiologic studies, among individuals, that religion— broadly assessed through frequency of attending worship services—is associated with lower all-cause and cause-specific mortality attributed to suicide, alcohol, cardiovascular disease and cancer. Religious norms, ... |
Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic | |
Adenovirus and Herpesvirus Diversity in Free-Ranging Great Apes in the Sangha Region of the Republic of Congo | Infectious diseases have caused die-offs in both free-ranging gorillas and chimpanzees. Understanding pathogen diversity and disease ecology is therefore critical for conserving these endangered animals. To determine viral diversity in free-ranging, non-habituated gorillas and chimpanzees in the Republic of Congo, gene... |
Viral tricks to grid-lock the type I interferon system | Type I interferons (IFN) play a critical role in the innate immune avant-garde against viral infections. Virtually all viruses have developed means to counteract the induction, signaling or antiviral actions of the IFN circuit. Over 170 different virus-encoded IFN-antagonists from 93 distinct viruses have been describe... |
Infections virales émergentes | SUMMARY Emerging and re-emerging infectious diseases have again entered the public arena in recent years. This is due to factors such as evolving lifestyles, ecological and socio-political upheavals, and recent diagnostic advances. Numerous pathogens, including viruses like West Nile, Chikungunya and Japanese encephali... |
Akute Bronchitis und Influenza | |
Electroencephalogram (EEG) in COVID-19: a systematic retrospective study | Abstract Objectives: Although rare, neurological manifestations in SARS-CoV-2 infection are increasingly being reported. We conducted a retrospective systematic study to describe the electroencephalography (EEG) characteristics in this disease, looking for specific patterns. Methods: EEGs performed in patients with pos... |
Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus (SFTSV), which is a novel bunyavirus. SFTSV was first isolated from patients who presented with fever, thrombocytopenia, leukocytopenia, and multiorgan dysfunction in China. Subsequently, it was found to... |
Detection and complete genome characterization of human enterovirus 118 from children with acute respiratory disease in China | Enterovirus 118 (EV-118) within species HEV-C was detected in two 5-month-old boys with pneumonia in China. The EV-118 from both cases was genetically closer to ISR10 strain from Israel than to PER161 strain from Peru based on VP1 gene sequences. The complete genome of the detected EV-118 consists of 7,360 nucleotides,... |
Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells | Abstract The herpes simplex virus type I (HSV-1) US11 protein is an RNA-binding multifunctional regulator that specifically and stably associates with nucleoli. Although the C-terminal part of US11 was responsible for its nucleolar localization, the precise nucleolar localization signal (NoLS) and nuclear export signal... |
Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike Protein | Porcine epidemic diarrhea virus (PEDV) causes high mortality in neonatal piglets; however, effective and safe vaccines are still not available. We hypothesized that inactivation of the 2′-O-methyltransferase (2′-O-MTase) activity of nsp16 and the endocytosis signal of the spike protein attenuates PEDV yet retains its i... |
Comments on "Cross‐species transmission of the newly identified coronavirus 2019‐nCoV" | After reading the article speculating that novel coronavirus from Wuhan may be transmitted to humans through snakes, I think the most critical analysis method is synonymous codon usage analysis, which estimated the relative synonymous codon usage (RSCU) of the 2019‐nCoV and its potential hosts. This article is protecte... |
Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herds | Porcine epidemic diarrhea virus (PEDV) spread rapidly after being diagnosed in the USA in April 2013. In this study we assessed whether PEDV could become airborne and if so, whether the virus was infectious. Air samples were collected both from a room containing experimentally infected pigs and at various distances fro... |
Multiple Presentations of LRBA Deficiency: a Single-Center Experience | INTRODUCTION: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency categorized as common variable immunodeficiency associated with autoimmune manifestations and inflammatory bowel diseases; however, the clinical spectrum has been extended. Here, we present our cohort of Turkish LRBA-... |
Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights | Abstract Rheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destructio... |
A weapon the world needs | Both bottom-up and top-down planning is needed to prevent a global economic disaster. Michael T. Osterholm calls for action at all levels. |
Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must? | Diagnostic electron microscopy (DEM) was an essential component of viral diagnosis until the development of highly sensitive nucleic acid amplification techniques (NAT). The simple negative staining technique of DEM was applied widely to smallpox diagnosis until the world-wide eradication of the human-specific pathogen... |
Domestic Pig Unlikely Reservoir for MERS-CoV | We tested the suitability of the domestic pig as a model for Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Inoculation did not cause disease, but a low level of virus replication, shedding, and seroconversion were observed. Pigs do not recapitulate human MERS-CoV and are unlikely to constitute a re... |
An outbreak of cutaneous anthrax in Yunnan, China | |
Beyond interferon | Interferon (IFN)-α has reigned supreme for decades as biotech's blockbuster antiviral. That looks set to change with a raft of antibody and nucleic acid therapies progressing through the pipeline. |
Antigen-conjugated N-trimethylaminoethylmethacrylate Chitosan Nanoparticles Induce Strong Immune Responses After Nasal Administration | PURPOSE: Antigens were conjugated on the surface of N-trimethylaminoethylmethacrylate chitosan (TMC) nanoparticles to induce systemic and mucosal immune responses after nasal immunization. METHODS: TMC was synthesized by free radical polymerization and blank nanoparticles were prepared by ionic crosslinking of TMC and ... |
The COVID‐19 Airway Management Isolation Chamber (CAMIC) for Ears | |
Rapid and sensitive detection of canine distemper virus by one-tube reverse transcription-insulated isothermal polymerase chain reaction | BACKGROUND: Canine distemper virus (CDV) has been associated with outbreaks of canine infectious respiratory disease in shelters and boarding kennel environments. POCKIT(TM) Nucleic Acid Analyzer is a field-deployable device capable of generating automatically interpreted insulated isothermal polymerase chain reaction ... |
Use of the Smartphone and Self-Concept in University Students According to the Gender Variable | The university stage comprises a very important and vital period in the modification of students’ lifestyles, and these changes can affect their self-concept. The excessive use of technology today can also influence the formation of their identity. The aim of this study is to analyze the relationship between self-conce... |
Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP‐1 and NF‐κB | Infection with different picornaviruses can cause meningitis/encephalitis in humans and experimental animals. To investigate the mechanisms of such inflammatory diseases, potential chemokine gene activation in human astrocytes was investigated following infection with Theiler's murine encephalomyelitis virus (TMEV), co... |
Wenn Viren viral gehen | |
Causes of fever in Gabonese children: a cross-sectional hospital-based study | The causes of infections in pediatric populations differ between age groups and settings, particularly in the tropics. Such differences in epidemiology may lead to misdiagnosis and ineffective empirical treatment. Here, we investigated the current spectrum of pathogens causing febrile diseases leading to pediatric hosp... |
The network effect: studying COVID-19 pathology with the Human Cell Atlas | The SARS coronavirus 2 (SARS-CoV-2) pandemic is a global challenge, which the scientific community has tackled by mounting extensive global collaborations, combining expertise in diverse areas and applying cutting-edge techniques, to dissect mechanisms underlying coronavirus disease-19 (COVID-19) pathology. The Human C... |
Emerging challenges in urban waste management in Tehran, Iran during the COVID-19 pandemic | • New challenges in MSW management in Tehran after the COVID-19 pandemic was studied. • Over 5.5 millions of PPEs are being daily discarded in Tehran during COVID-19. • Hospital wastes are being disposed of without undergoing any treatment in Tehran. • Landfilling of MSW has increased by 34.7% after the outbreak of COV... |
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