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Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhoea Virus Spike Protein | Since 2010, newly identified variants of porcine epidemic diarrhoea virus (PEDV) have caused high mortality in neonatal piglets which has devastated the swine industry. The spike (S) glycoprotein of PEDV contains multiple neutralizing epitopes and is a major target for PEDV neutralization and vaccine development. To un... |
Pandemic risk: how large are the expected losses? | There is an unmet need for greater investment in preparedness against major epidemics and pandemics. The arguments in favour of such investment have been largely based on estimates of the losses in national incomes that might occur as the result of a major epidemic or pandemic. Recently, we extended the estimate to inc... |
Development of price models for architectural and environmental quality for residential developments in Hong Kong | Factors affecting a residential unit's price are always of interest to homebuyers and building developers, especially in a city like Hong Kong which is known for expensive housing. Literature review indicates that the governing factors can be categorized into architectural and environmental attributes. Among different ... |
Evaluation of rapid antigen test for detection of SARS-CoV-2 virus | BACKGROUND: The rapid diagnosis of COVID-19 patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests. OBJECTIVE: To evaluate the performance of BIOCREDIT COVID-19 Ag test and compared it with real-time RT-PCR for... |
Hyperpyrexia and metabolic alkalosis in a COVID‐19 patient | Hyperpyrexia can be a challenging and serious complication of SARS‐CoV‐2 infection. This article is protected by copyright. All rights reserved. |
Summarizing US Wildlife Trade with an Eye Toward Assessing the Risk of Infectious Disease Introduction | The aim of this study was to characterize the role of the USA in the global exchange of wildlife and describe high volume trade with an eye toward prioritizing health risk assessment questions for further analysis. Here we summarize nearly 14 years (2000–2013) of the most comprehensive data available (USFWS LEMIS syste... |
Pediatrics in 21(st) Century and Beyond | Pediatrics is a dynamic discipline and there is awareness and hope for actualizing outstanding achievements in the field of child health in 21(st) century and beyond. Improved lifestyle and quality of children’s health is likely to reduce the burden of adult diseases and enhance longevity because seeds of most adult di... |
Isolation and characterization of dengue virus serotype 2 from the large dengue outbreak in Guangdong, China in 2014 | Dengue has been well recognized as a global public health threat, but only sporadic epidemics and imported cases were reported in recent decades in China. Since July 2014, an unexpected large dengue outbreak has occurred in Guangdong province, China, resulting in more than 40000 patients including six deaths. To clarif... |
Public health human resources: a comparative analysis of policy documents in two Canadian provinces | BACKGROUND: Amidst concerns regarding the capacity of the public health system to respond rapidly and appropriately to threats such as pandemics and terrorism, along with changing population health needs, governments have focused on strengthening public health systems. A key factor in a robust public health system is i... |
Expanding the use of alternative models to investigate novel aspects of immunity to microbial pathogens | |
Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 | BACKGROUND: Coronavirus disease 2019 (Covid-19) may disproportionately affect people with cardiovascular disease. Concern has been aroused regarding a potential harmful effect of angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) in this clinical context. METHODS: Using an observati... |
Sensitive and specific detection of strains of Japanese encephalitis virus using a one‐step TaqMan RT‐PCR technique | A rapid, sensitive, and accurate laboratory diagnostic test is needed for distinguishing Japanese encephalitis virus (JEV) from other diseases featuring similar clinical symptoms and also for preventing potential outbreaks. In this study, a TaqMan reverse transcription (RT)‐polymerase chain reaction (PCR) assay was dev... |
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs | SARS-CoV-2 encodes three putative ion channels: E, 8a, and 3a. In related SARS-CoV-1, 3a is implicated in viral release, inflammasome activation, and cell death and its deletion reduces viral titer and morbidity in animal models, suggesting 3a-targeted therapeutics could treat SARS and COVID-19. However, the structural... |
Complicated coronavirus disease 2019 (COVID‐19) in a psoriatic patient treated with ixekizumab | |
The impact of PD-L1 N-linked glycosylation on cancer therapy and clinical diagnosis | N-linked glycosylation is one of the most abundant posttranslational modifications of membrane-bound proteins in eukaryotes and affects a number of biological activities, including protein biosynthesis, protein stability, intracellular trafficking, subcellular localization, and ligand-receptor interaction. Accumulating... |
Applying the Lessons of SARS to Pandemic Influenza: An Evidence-based Approach to Mitigating the Stress Experienced by Healthcare Workers | We describe an evidence-based approach to enhancing the resilience of healthcare workers in preparation for an influenza pandemic, based on evidence about the stress associated with working in healthcare during the SARS outbreak. SARS was associated with significant long-term stress in healthcare workers, but not with ... |
Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers | |
Paramyxoviruses of Animals | Paramyxoviruses (some of which are also called parainfluenza viruses) cause a wide variety of diseases in animals. Many paramyxoviruses cause primarily respiratory disease, while others cause serious systemic disease. Many diseases caused by animal paramyxoviruses also have a neurological component or a reproductive di... |
Use of Transgenic Animals to Improve Human Health and Animal Production | Transgenic animals are more widely used for various purposes. Applications of animal transgenesis may be divided into three major categories: (i) to obtain information on gene function and regulation as well as on human diseases, (ii) to obtain high value products (recombinant pharmaceutical proteins and xeno‐organs fo... |
Are trans‐complementation systems suitable for hepatitis C virus life cycle studies? | Complementation is a naturally occurring genetic mechanism that has been studied for a number of plus‐strand RNA viruses. Although trans‐complementation is well documented for Flaviviridae family viruses, the first such system for hepatitis C virus (HCV) was only described in 2005. Since then, the development of a numb... |
Table des matieres | |
Frequency of human bocavirus (HBoV) infection among children with febrile respiratory symptoms in Argentina, Nicaragua and Peru | Please cite this paper as: Salmón‐Mulanovich et al. (2010) Frequency of human bocavirus (HBoV) infection among children with febrile respiratory symptoms in Argentina, Nicaragua and Peru. Influenza and Other Respiratory Viruses 5(1), 1–5. Background Globally, respiratory infections are the primary cause of illness in d... |
Babesia vesperuginis in insectivorous bats from China | BACKGROUND: To increase understanding of human bacterial and parasitic pathogens in bats, we investigated the prevalence of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii in bats from China. METHODS: Bats were captured from Mengyin County, Shandong Province of China using nets. DNA was extracted fr... |
Do Newton’s rules of reasoning guarantee truth … must they? | Abstract Newton’s Principia introduces four rules of reasoning for natural philosophy. Although useful, there is a concern about whether Newton’s rules guarantee truth. After redirecting the discussion from truth to validity, I show that these rules are valid insofar as they fulfill Goodman’s criteria for inductive rul... |
Chapter 4 Replication | This chapter provides an overview of the key stages in virus replication, including the historic experiments which resulted in our present understanding. It describes, step by step, how replication unfolds, starting with the initial interaction between the virus and a host cell and finishing with the release of infecti... |
Obstetric Anesthesia During the Coronavirus Disease 2019 Pandemic | With increasing numbers of Coronavirus Disease 2019 (COVID19) cases due to efficient human-to-human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States, preparation for the unpredictable setting of labor and delivery is paramount. The priorities are 2-fold in the management... |
Recommandations de la Société Française de Médecine du Travail (SFMT): le formol 4% est-il virucide sur le COVID-19? Au bout de combien de temps de fixation? 27 mars 2020 | |
Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model | BACKGROUND: Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs). In several animal models of human diseases, MSC-EVs mimic the beneficial effects of MSCs. Influenza viruses cause annual outbreaks of acu... |
Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway | The management of acute neurological conditions, particularly acute ischemic stroke, in the context of Coronavirus disease 2019 (COVID-19), is of importance, considering the risk of infection to the healthcare workers and patients and emerging evidence of the neuroinvasive potential of the virus. There are variations i... |
Rapid guide to the management of cardiac patients during the COVID-19 pandemic in Egypt: “a position statement of the Egyptian Society of Cardiology” | COVID-19 pandemic poses an enormous challenge to healthcare system in Egypt. This document is a position statement from the Egyptian Society of Cardiology. It aims to provide information to cardiovascular healthcare providers in Egypt to guarantee delivery of quality patient care and ensure adequate levels of protectio... |
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas | Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving g... |
Frequency of respiratory virus infections and next-generation analysis of influenza A/H1N1pdm09 dynamics in the lower respiratory tract of patients admitted to the ICU | Recent molecular diagnostic methods have significantly improved the diagnosis of viral pneumonia in intensive care units (ICUs). It has been observed that 222G/N changes in the HA gene of H1N1pdm09 are associated with increased lower respiratory tract (LRT) replication and worse clinical outcome. In the present study, ... |
Preliminary study on the tick population of Benin wildlife at the moment of its invasion by the Rhipicephalus microplus tick (Canestrini, 1888) | BACKGROUND AND AIM: Rhipicephalus microplus (Rm) is one of the most problematic livestock tick species in the world. Its rapid propagation and resistance to acaricides make it control difficult in the sub-region and Benin particularly. The aim of this work was to check its presence in wildlife and to confirm the possib... |
Providing nutritional care to cancer patients during the COVID-19 pandemic: an Italian perspective | The COVID-19 outbreak has drastically changed practices inside hospitals, which include oncology routines. In oncology, malnutrition was and certainly still is a frequent problem associated with an increase in treatment-related toxicity, a reduced response to cancer treatment, an impaired quality of life, and a worse o... |
Heparin‐binding protein, lysozyme, and inflammatory cytokines in bronchoalveolar lavage fluid as diagnostic tools for pulmonary infection in lung transplanted patients | Pulmonary infection is a common complication after lung transplantation, and early detection is crucial for outcome. However, the condition can be clinically difficult to diagnose and to distinguish from rejection. The aim of this prospective study was to evaluate heparin‐binding protein (HBP), lysozyme, and the cytoki... |
Airflow Decline after Myeloablative Allogeneic Hematopoietic Cell Transplantation: The Role of Community Respiratory Viruses | We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with... |
COVID-19: immunopathology and its implications for therapy | Severe coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 pr... |
Saturation Mutagenesis reveals that GLU54 of Norovirus 3C-like Protease is not Essential for the Proteolytic Activity | The norovirus 3C-like protease is a member of the chymotrypsin-like serine protease superfamily. Previous characterization of its crystal structure has implicated the Glu54–His30–Cys139 triad in the catalysis. In the present study, the Glu54 residue of the protease was subjected to site-saturation mutagenesis, with the... |
Covid-19 | Besmetting met het coronavirus kan leiden tot de ziekte covid-19. In dit artikel een overzicht van symptomen, behandeling en verpleegkundige aandachtspunten.(*) De toets bij dit artikel levert 2 accreditatiepunten op. |
Respiratory Tract Samples, Viral Load, and Genome Fraction Yield in Patients With Middle East Respiratory Syndrome | Background. Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samples from 112 patients infected with the recently discovered... |
Chapter 9 Pregnancy and Neonatal Care of SCNT Animals | Since the birth of the first somatic cell nuclear transfer (SCNT) animal in 1996, SCNT has been successfully applied to produce live animals in many species, but its successful application in animal production has been hampered by heavy fetal and postnatal losses and widespread public concern. So far, cattle remain the... |
Ode à nos Vieux en temps de Covid-19 | |
Structural Basis of the Potential Binding Mechanism of Remdesivir to SARS-CoV-2 RNA-Dependent RNA Polymerase | [Image: see text] Starting from late 2019, the coronavirus disease 2019 (COVID-19) has emerged as a once-in-a-century pandemic with deadly consequences, which urgently calls for new treatments, cures, and supporting apparatuses. Recently, because of its positive results in clinical trials, remdesivir was approved by th... |
The pervasive issue of racism and its impact on infertility patients: what can we do as reproductive endocrinologists? | Following the horrific events surrounding the death of George Floyd, we aim to shed some light on our perceptions of the pervasive issue of racism in America and how it impacts the work we do as reproductive endocrinologists. This issue is deeply rooted, and tackling it will involve a multifaceted approach. Ultimately,... |
Emerging viral diseases of livestock in the developing world | Emerging and reemerging viral diseases of livestock and human beings are in sharp rise in recent years. Importantly, many of these viruses, including influenza, Hendra, Nipah and corona are of zoonotic importance. Several viral diseases of livestock such as bluetongue, peste des petits ruminants, camel pox, equine infe... |
COVID-19 presenting as stroke | Abstract Objective Acute stroke remains a medical emergency even during the COVID-19 pandemic. Most patients with COVID-19 present with constitutional and respiratory symptoms, some patients present with atypical symptoms including gastrointestinal, cardiovascular, or neurological symptoms. Here we present a series of ... |
Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2) | Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2). Our observa... |
Etiology of Community-Acquired Pneumonia: Increased Microbiological Yield with New Diagnostic Methods | BACKGROUND: The microbial etiology of community-acquired pneumonia (CAP) is still not well characterized. During the past few years, polymerase chain reaction (PCR)-based methods have been developed for many pathogens causing respiratory tract infections. The aim of this study was to determine the etiology of CAP among... |
Characterization of Rv0888, a Novel Extracellular Nuclease from Mycobacterium tuberculosis | Bacterial extracellular nucleases play important roles in virulence, biofilm formation, utilization of extracellular DNA as a nutrient, and degradation of neutrophil DNA extracellular traps. However, there is no current data available for extracellular nucleases derived from M. tuberculosis. Herein, we have identified ... |
Validation of a SARS-CoV-2 spike protein ELISA for use in contact investigations and sero-surveillance | Since emergence of SARS-CoV-2 in late 2019, there has been a critical need to understand prevalence, transmission patterns, to calculate the burden of disease and case fatality rates. Molecular diagnostics, the gold standard for identifying viremic cases, are not ideal for determining true case counts and rates of asym... |
A Novel Enediynyl Peptide Inhibitor of Furin That Blocks Processing of proPDGF-A, B and proVEGF-C | BACKGROUND: Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis. As a result it is considered a major target for intervention of these... |
Roles of the antioxidant properties of icariin and its phosphorylated derivative in the protection against duck virus hepatitis | BACKGROUND: Duck viral hepatitis (DVH) is an acute disease of young ducklings with few convenient and effective veterinary drugs to treat. In pathology, present study mainly focused on the immune mechanism, but very few studies have concerned with the role of oxidative stress in the pathogenesis of DVH. To study the an... |
Urban disaster preparedness of Hong Kong residents: A territory-wide survey | Abstract Objective To assess the state of community disaster preparedness of Hong Kong residents and to identify factors associated with adequate preparedness behaviors. Design A cross-sectional survey using random Global Positioning System (GPS) spatial sampling conducted from the 8 August 2015 to 6 September 2015. Pa... |
Telemedicine for parkinsonism: A two-step model based on the COVID-19 experience in Milan, Italy | • Lifting lockdown restrictions (‘Phase Two’) may be more dangerous than ‘Phase One’ of COVID-19 for patients with parkinsonism traveling to in-person care sites. • During the crisis, a telemedicine program for patients with parkinsonism was boosted in Milan, Italy. • We propose a two-step model integrating a telenursi... |
Immunosuppressive agents for dermatological indications in the ongoing COVID 19 pandemic: rationalizing use and clinical applicability | The ongoing COVID 19 epidemic has brought to the fore many concerns related to use of immunosuppressive agents (ISAs) in dermatology. While it is unclear whether the patients on ISAs for skin conditions are more prone to develop COVID 19, and what impact the ISA may have on the clinical outcome if a patient does get in... |
The role of children in the transmission of mild SARS‐CoV‐2 infection | We thank dr. Ludvigsson (1) on his effort to improve knowledge on SARS-CoV-2 infection in children. In trying to understand the spread of the disease, one of the most notable features is that only a small number of severe SARS-CoV-2 infections have involved children. The huge age disparity in disease severity might be ... |
Clinical implications of the COVID‐19 pandemic on dental education | |
Serum protein electrophoretic profile in diarrheic neonatal calves | The electrophoretic profile of clinically healthy newborn calves and calves with neonatal diarrhea was compared. Blood samples were collected at 3 and 10 days of age from 11 calves that remained clinically healthy throughout the study period and 14 calves with diarrhea. A significant reduction in the gamma globulins wa... |
Religious Nationalism and the Coronavirus Pandemic: Soul-Sucking Evangelicals and Branch Covidians Make America Sick Again | This article investigates the response to the coronavirus crisis by Evangelical Christian nationalists in the USA. The article outlines the curious mediaverse of religious nationalism—its post-truth and fake news aspects in particular—links religious nationalism to American exceptionalism, and analyzes conflicts betwee... |
Biophysical Reviews—Quantitative analysis of biological phenomenon | This Editorial first describes the articles constituting the current Issue (Volume 12 Issue 3). It then goes on to outline the formal invitation procedure for those interested in submitting a review article to the journal. The Editorial concludes by describing the nomination process for the 2021 Michèle Auger Award for... |
The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory | |
Inter‐country Distancing, Globalization and the Coronavirus Pandemic | Originating in China, the Coronavirus has reached the world at different speeds and levels of strength. This paper provides an initial understanding of some driving factors and their consequences. Since transmission requires people, the human factor behind globalization is essential. Globalization, a major force behind... |
Poxvirus Bioinformatics Resource Center: a comprehensive Poxviridae informational and analytical resource | The Poxvirus Bioinformatics Resource Center (PBRC) has been established to provide informational and analytical resources to the scientific community to aid research directed at providing a better understanding of the Poxviridae family of viruses. The PBRC was specifically established as the result of the concern that ... |
Excess Out-Of-Hospital Mortality and Declining Oxygen Saturation: The Sentinel Role of EMS Data in the COVID-19 Crisis in Tijuana, Mexico | OBJECTIVE: Emergency medical services (EMS) may serve as a key source of real-time data about the evolving health of COVID-19 affected populations, especially in low-and-middle-income countries (LMICs) with less rapid and reliable vital statistic registration systems. Although official COVID-19 statistics in Mexico rep... |
Knowledge mapping of tourism demand forecasting research | Utilizing a scientometric review of global trends and structure from 388 bibliographic records over two decades (1999–2018), this study seeks to advance the building of comprehensive knowledge maps that draw upon global travel demand studies. The study, using the techniques of co-citation analysis, collaboration networ... |
Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century | Air pollution is a severe threat to public health globally, affecting everyone in developed and developing countries alike. Among different air pollutants, particulate matter (PM), particularly combustion-produced fine PM (PM(2.5)) has been shown to play a major role in inducing various adverse health effects. Strong a... |
Genome Sequence of Canine Polyomavirus in Respiratory Secretions of Dogs with Pneumonia of Unknown Etiology | We report here the first canine polyomavirus genome, identified by metagenomics in respiratory secretions of two dogs with severe pneumonia, which tested negative for all canine respiratory pathogens except Mycoplasma cynos. The isolate, Canis familiaris polyomavirus 1 (DogPyV-1), is a beta polyomavirus whose closest k... |
Fatal Severe Acute Respiratory Syndrome Is Associated with Multiorgan Involvement by Coronavirus | Severe acute respiratory syndrome (SARS) is characterized by pulmonary compromise; however, patients often have evidence of other organ dysfunction that may reflect extrapulmonary dissemination of SARS coronavirus (SARS-CoV). We report on the distribution and viral load of SARS-CoV in multiple organ samples from patien... |
Emergence of deadly severe acute respiratory syndrome coronavirus-2 during 2019–2020 | Wuhan, the city in Hubei province in China is in the focus of global community due to the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), formerly known as 2019-nCoV. The virus emerged in humans from Wuhan seafood market probably via zoonotic trans... |
Arterial hypertension and the risk of severity and mortality of COVID-19 | We have read with great interest the recently published study from Guan et al. [1] entitled Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis. To the best of our knowledge this is the first large scale study that focuses on independent clinical risk factors associated with a comp... |
COVID-19: What are the challenges for NHS surgery? | |
Infection par le SARS-CoV-2 chez les femmes enceintes. État des connaissances et proposition de prise en charge. CNGOF | Résumé Un nouveau coronavirus (SARS-CoV-2) mis en évidence en fin d’année 2019 en Chine se diffuse à travers tous les continents. Le plus souvent à l’origine d’un syndrome infectieux sans gravité, associant à différents degrés des symptômes bénins (fièvre, toux, myalgies, céphalées et éventuels troubles digestifs) le S... |
Essential oil of Artemisia vestita exhibits potent in vitro and in vivo antibacterial activity: Investigation of the effect of oil on biofilm formation, leakage of potassium ions and survival curve measurement | The aim of the present study was to investigate the chemical composition of the essential oil of Artemisia vestita and to determine the antibacterial activity of the essential oil and its two major components, grandisol and 1,8-cineole, against certain respiratory infection-causing bacterial strains, in vitro and in vi... |
COVID-19: POSTMORTEM DIAGNOSTIC AND BIOSAFETY CONSIDERATIONS | As a result of the 2019 novel human coronavirus (COVID-19) global spread, medical examiner/coroner offices will inevitably encounter increased numbers of COVID-19-infected decedents at autopsy. While in some cases a history of fever and/or respiratory distress (e.g. cough or shortness of breath) may suggest the diagnos... |
Chapter 101 Middle Ear and Eustachian Tube Mucosal Immunology | Abstract Mucosal immune responses within the middle ear and eustachian tube generally provide an effective and efficient response to the presence of microbial pathogens, with approximately 80% of clinically recognizable middle ear infections resolved within 7days. Particularly for young children aged less than 3years o... |
Chest CT imaging signature of COVID-19 infection: in pursuit of the scientific evidence | Abstract Background Chest computed tomography (CT) may be used for the diagnosis of Corona virus disease 2019 (COVID-19), but clear scientific evidence is lacking. Therefore, we systematically reviewed and meta-analyzed the chest CT imaging signature of COVID-19. Methods A systematic literature search was performed for... |
Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans | RNA viruses are proficient at switching to novel host species due to their fast mutation rates. Implicit in this assumption is the need to evolve adaptations in the new host species to exploit their cells efficiently. However, SARS-CoV-2 has required no significant adaptation to humans since the pandemic began, with no... |
Regulation of cell volume and water transport – An old fundamental role of the renin angiotensin aldosterone system components at the cellular level | The expression and the role of renin angiotensin aldosterone system (RAAS) components on regulation of cell volume and water transport on vertebrates and invertebrates were reviewed. The presence of these components even in simple organisms like leeches and their relevance for the control of cellular volume and water t... |
Public Attitudes, Behaviors, and Beliefs Related to COVID-19, Stay-at-Home Orders, Nonessential Business Closures, and Public Health Guidance — United States, New York City, and Los Angeles, May 5–12, 2020 | SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is thought to be transmitted mainly by person-to-person contact (1). Implementation of nationwide public health orders to limit person-to-person interaction and of guidance on personal protective practices can slow transmission (2,3). Such strategie... |
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway | SARS coronavirus (SARS-CoV) papain-like protease (PLpro) has been identified in TGF-β1 up-regulation in human promonocytes (Proteomics 2012, 12: 3193-205). This study investigates the mechanisms of SARS-CoV PLpro-induced TGF-β1 promoter activation in human lung epithelial cells and mouse models. SARS-CoV PLpro dose- an... |
T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves | The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA(+)CD62L(+)), central memory (CM, CD45RA(−)CD6... |
COVID-19 and surgical activities | |
What’s Important: What Is Our Role in the COVID-19 Pandemic? | |
“Cell Phone Acne” Epidemic during COVID‐19 Pandemic | As the world plunges into the longest and the biggest lockdown in world’s history, most of us are turning towards an increased use of mobile phones as the most convenient way to stay connected. However, this convenience is also taking a toll on the overall skin health, particularly in the patients of acne. |
Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 | A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China. Information on reported cases strongly indicates human-to-human spread, and the most recent information is increasingly indicative of sustained human-to-human transmission. While the overall severity profile among... |
The Effects of an Online Mind-Body Training Program on Stress, Coping Strategies, Emotional Intelligence, Resilience and Psychological State | The goal of this study was to evaluate the effects of an online mind-body training (MBT) program on participants’ stress, anger, coping strategies, emotional intelligence, resilience, and positive and negative affect. Forty-two healthy women participated in an online MBT program for approximately 8–10 minutes a day for... |
Pharmacists Roles and Responsibilities During Epidemics and Pandemics in Saudi Arabia: An Opinion Paper from the Saudi Society of Clinical Pharmacy | Abstract On the 2nd of March 2020, Kingdom of Saudi Arabia confirmed its first case of the coronavirus's newly emerging strain, causing coronavirus disease 2019 (COVID-19). Soon after, the number of confirmed cases started to increase nationally. In light of the emerging outbreak, all healthcare professionals, includin... |
Pathophysiology of diarrhoea induced by a combined infection with transmissible gastroenteritis virus and enterotoxigenic Escherichia coli in newly-weaned piglets and the effect of flurbiprofen treatment | In newly-weaned 3–4 week old piglets (n=29) diarrhoea (100%) and vomiting (65%) were induced by inoculation with transmissible gastroenteritis virus and enterotoxigenic E. coli strains (0(149):K(91):K(88ac); LT, STa and STb enterotoxin positive). This combined infection resulted in pronounced mortality within 7 days. D... |
The characteristics and outcomes of 681 severe cases with COVID-19 in China | PURPOSE: To clarify the epidemiological, clinical, and therapeutic features of patients with severe COVID-19. METHODS: In this study, we enrolled 681 patients with confirmed cases of severe COVID-19. The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected. RESULTS: The median ... |
Response to the challenges of pandemic H1N1 in a small island state: the Barbadian experience | BACKGROUND: Having been overwhelmed by the complexity of the response needed for the severe acute respiratory syndrome (SARS) epidemic, public health professionals in the small island state of Barbados put various measures in place to improve its response in the event of a pandemic METHODS: Data for this study was coll... |
The City Under COVID‐19: Podcasting As Digital Methodology | This critical commentary reflects on a rapidly mobilised international podcast project, in which 25 urban scholars from around the world provided audio recordings about their cities during COVID‐19. New digital tools are increasing the speeds, formats and breadth of the research and communication mediums available to r... |
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs | Drug repositioning is the only feasible option to immediately address the COVID-19 global challenge. We screened a panel of 48 FDA-approved drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were preselected by an assay of SARS-CoV. We identified 24 potential antiviral drug candidates agai... |
Severe Pertussis Infections in the United States, 2011–2015 | BACKGROUND: The incidence of pertussis in the United States has increased in recent years. While characteristics of severe pertussis infection have been described in infants, fewer data are available in older children and adults. In this analysis, we characterize pertussis infections in hospitalized patients of all age... |
Admission fasting blood glucose predicts 30‐day poor outcome in patients hospitalized for COVID‐19 pneumonia | |
Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID‐19 pandemic | Nasopharyngeal carcinoma is endemic in southern parts of China including Hong Kong. Primary treatment entails radiotherapy ± chemotherapy depending on disease stage at presentation. Surgery is offered as a means of salvage for persistent and recurrent disease. Comprehensive preoperative work‐up, careful patient selecti... |
On the Alert for Cytokine Storm: Immunopathology in COVID‐19 | Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical ... |
Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats | Bats have been identified as a natural reservoir of a variety of coronaviruses (CoVs). Several of them have caused diseases in humans and domestic animals by interspecies transmission. Considering the diversity of bat coronaviruses, bat species and populations, we expect to discover more bat CoVs through virus surveill... |
Low-Dose Abiraterone, a Rare European Commodity | |
AID in Antibody Diversification: There and Back again | Abstract Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation and class switch recombination. AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary ... |
Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies | BACKGROUND: During febrile neutropenia in only 30 to 60 percent an infectious agent is identified. This diagnostic gap could hypothetically be reduced with the broad implementation of molecular detection techniques like PCR, which has revolutionized the detection of infectious diseases during the last two decades. FIND... |
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