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Parallel pathogens in the upper and lower respiratory tracts in children with a respiratory tract infection, as revealed by the Filmarray assay | Abstract Background Respiratory tract infection (RTI) is a common disease among children of all ages that causes high hospitalization and mortality rates. Infection with more than one pathogen has been reported in RTI; however, the association of the pathogen spectrum in upper and lower respiratory tract infections rem... |
From the American Epicenter: Coronavirus Disease 2019 in Patients with Inflammatory Bowel Disease in the New York City Metropolitan Area | BACKGROUND: We aimed to characterize patients with inflammatory bowel disease (IBD) and novel coronavirus disease 2019 (COVID-19). METHODS: We performed a case series of patients with IBD and confirmed or highly suspected COVID-19 to assess rates of severe outcomes. RESULTS: We identified 83 patients with IBD with conf... |
Impact of the COVID-19 Pandemic on Mental Health and Social Support among Adult Egyptians | The psychological impact of outbreaks on individuals includes an intense and wide range of psychiatric morbidities. People are likely to experience feelings as; worry about being infected or getting sick, increased self-blame, and helplessness. This study aimed to assess the impact of COVID-19 on mental health and soci... |
Potential role of IL‐17 blocking agents in the treatment of severe COVID‐19? | |
SARS-related Virus Predating SARS Outbreak, Hong Kong | Using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome–associated coronavirus (SARS-CoV) and/or animal SARS-CoV–like virus in 17 (1.8%) of 938 adults recruited in 2001. This finding suggests that a small proportion of healthy persons in Hong Kong had been e... |
The Diagnosis of Pandemic Coronavirus Pneumonia: A Review of Radiology Examination and Laboratory Test | Abstract Since the outbreak of novel coronavirus disease 2019 (COVID-19), epidemic prevention strategies have been implemented worldwide. For the sake of controlling the infectious coronavirus pneumonia, early diagnosis and quarantine play an imperative role. Currently, the mainstream diagnostic methods are imaging and... |
Against Ebola: type I interferon guard risk and mesenchymal stromal cell combat sepsis | The 2014 Ebola outbreak in West Africa triggered a global crisis. Nine countries have reported more than 20 000 infection cases in total and nearly 8000 lives have been lost. The actual death toll is likely much higher than this figure; the death rate is as high as 70%, considering confirmed cases. The Ebola virus laun... |
Natural protection of ocular surface from viral infections – a hypothesis | A pandemic outbreak of a viral respiratory infection (COVID-19) caused by a coronavirus (SARS-CoV-2) prompted a multitude of research focused on various aspects of this disease. One of the interesting aspects of the clinical manifestation of the infection is an accompanying ocular surface viral infection, viral conjunc... |
A Hospital Partnership with a Nursing Home Experiencing a COVID‐19 Outbreak: Description of a Multi‐Phase Emergency Response in Toronto, Canada | Nursing homes have become “ground zero” for the coronavirus disease 2019 (COVID‐19) epidemic in North America, with homes experiencing widespread outbreaks resulting in severe morbidity and mortality among its residents. This manuscript describes a 371‐bed acute care hospital's emergency response to a 126‐bed nursing h... |
Comparative efficacy of the front-line anti-HBV drugs in nucleos(t)ide analogue-naive chronic hepatitis B: A protocol for systematic review and network meta-analysis | BACKGROUND: During the COVID-19 period, there was a huge gap in the understanding of masks between east and west. At the same time, the mechanism of the mask and the effect after use, also appeared differences. The Objective of this Meta-analysis is to systematically evaluate the efficacy of masks for influenza in the ... |
The response of the mental health network of the Salamanca area to the COVID-19 pandemic: The role of the telemedicine. | The COVID-19 pandemic reached world-wide causing a great impact on healthcare services. The aim of this work is to describe the response of the Mental Health Network of the Salamanca´ Area (Spain) to this crisis and the reorganization of its resources within the first 8 weeks after the state of alarm was declared. The ... |
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis | Abstract Background & Aims Infection with SARS-CoV-2 causes COVID-19, which has been characterized by fever, respiratory, and gastrointestinal symptoms as well as shedding of virus RNA into feces. We performed a systematic review and meta-analysis of published gastrointestinal symptoms and detection of virus in stool, ... |
Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs | Ribonuclease L (RNase L) is a metal-ion–independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the biological significance of RNase L, the RNAs cleaved by this enzyme are poorly defined. In this study, we used deep sequencing methods to reveal the frequency and lo... |
COVID‐19 During the Opioid Epidemic – Exacerbation of Stigma and Vulnerabilities | |
Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis | BACKGROUND: Flavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern. Preexisting chronic conditions such as cardiovascular diseases, diabetes, obesity, and asthma were thought to predict risk of progression to severe infections. ... |
Novel viral translation strategies | Viral genomes are compact and encode a limited number of proteins. Because they do not encode components of the translational machinery, viruses exhibit an absolute dependence on the host ribosome and factors for viral messenger RNA (mRNA) translation. In order to recruit the host ribosome, viruses have evolved unique ... |
Respiratory protection for health care workers: A 2020 COVID‐19 perspective | As the US health care system began to respond to the coronavirus disease‐2019 pandemic, demand for respiratory personal protective equipment (PPE) increased precipitously, as did the number of users. This commentary discusses ensuing deviations from accepted respiratory PPE program practices, which potentially increase... |
Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial | BACKGROUND: Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The Clinical utilisation of respiratory elastance (CURE) trial is a two-arm, randomised controlled tri... |
The impact of oil and gold price fluctuations on the South African equity market: Volatility spillovers and financial policy implications | Abstract This paper assesses the impact of gold and oil price fluctuations on the volatility of the South African stock market and its component indices or sectors – namely, the financial, industrial and resource sectors – to infer the link between the commodity and stock markets in South Africa. Use is made of the vec... |
Propagation of the Kakegawa strain of bovine coronavirus in suckling mice, rats and hamsters | The Kakegawa strain of bovine coronavirus was easily propagated in suckling mice. Infected animals died with nervous symptoms, and serial passage was readily accomplished by intracerebral inoculation with brain emulsions. The 3rd passage viral material from infected mice evoked the same disease in suckling mice, rats a... |
Serology of Severe Acute Respiratory Syndrome: Implications for Surveillance and Outcome | Background. Severe acute respiratory syndrome (SARS) is a novel infectious disease. No information is currently available on host-specific immunity against the SARS coronavirus (CoV), and detailed characteristics of the epidemiology of SARS CoV infection have not been identified. Methods. ELISA was used to detect antib... |
Viral Diversity, Prey Preference, and Bartonella Prevalence in Desmodus rotundus in Guatemala | Certain bat species serve as natural reservoirs for pathogens in several key viral families including henipa-, lyssa-, corona-, and filoviruses, which may pose serious threats to human health. The Common Vampire Bat (Desmodus rotundus), due to its abundance, sanguivorous feeding habit involving humans and domestic anim... |
Is Hydroxychloroquine a Possible Postexposure Prophylaxis Drug to Limit the Transmission to Healthcare Workers Exposed to Coronavirus Disease 2019? | |
The Zebrafish Disease and Drug Screening Model: A Strong Ally Against Covid-19 | |
Genomic and antigenic variations of the HE glycoprotein of bovine coronaviruses associated with neonatal calf diarrhea and winter dysentery | In this study, we attempted to define differences in the hemagglutinin-esterase (HE) glycoprotein between 11 bovine coronaviruses (BCV) recent (post-1991) and past (pre-1991) isolates from neonatal calf diarrhoea (NCD) and winter dysentery (WD) syndromes as a basis for strain differentiation related to the clinical sou... |
Geranium and Lemon Essential Oils and Their Active Compounds Downregulate Angiotensin-Converting Enzyme 2 (ACE2), a SARS-CoV-2 Spike Receptor-Binding Domain, in Epithelial Cells. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease-2019 (COVID-19), is a pandemic disease that has been declared as modern history's gravest health emergency worldwide. Until now, no precise treatment modality has been developed. The angiotensin-converting enzyme 2 (ACE2) re... |
Emerging transfusion transmitted infections: species barriers and the risks for transfusion medicine | |
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease | Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules that activate the innate immune response. Here we examine the structural... |
Head and Neck Cancer Care in the COVID-19 Pandemic: A Brief Update | |
Organ cultures of human Fallopian tubes for the propagation of viruses | Attempts were made to grow certain viruses in organ cultures of Fallopian tube. Influenza A(2) and B, parainfluenza type 2, rhinovirus type 2, ECHO virus type 11 and adenovirus type 7 were observed to multiply, but poliovirus type 1, a human “coronavirus” and rhinovirus type 3 did not. |
Embeddedness in cross-agency collaboration and emergency management capability: Evidence from Shanghai's urban contingency plans | Abstract Governments are increasingly emphasizing emergency management in response to public emergencies that cause extensive consequences and involve multiple government agencies. One of the influential measures adopted by governments is the establishment of cross-agency networks. Scholars have validated the importanc... |
Full-genome sequences of the first two SARS-CoV-2 viruses from India | BACKGROUND & OBJECTIVES: Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally affected 195 countries. In India, suspected cases were screened for SARS-CoV-2 as per the advisory of the Ministry of Health and Family Welfare. The objective of this study was to characterize SARS-Co... |
Chapter 3 Blood Vital but Potentially Dangerous | Abstract This chapter describes the role of blood in the transmission of viruses and recounts early efforts to ensure the safety of the US blood supply. A person of average weight has approximately 5quarts of blood containing more than 20 trillion individual cells. The discovery of blood groups by Karl Landsteiner in 1... |
COVID‐19Clinical trials: quality matters more than quantity | Despite the ferment aroused in the scientific community by the COVID‐19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of registered... |
Effect of Pandemic on Union Organizing | |
Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort | BACKGROUND: The interferon-inducible transmembrane protein-3 (IFITM3) is a protein that restricts multiple pathogenic viruses such as influenza virus. The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher h... |
Assessment of flavaglines as potential chikungunya virus entry inhibitors | Chikungunya virus (CHIKV) is a re‐emerging mosquito‐borne alphavirus that recently caused large epidemics in islands in, and countries around, the Indian Ocean. There is currently no specific drug for therapeutic treatment or for use as a prophylactic agent against infection and no commercially available vaccine. Prohi... |
The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization | 7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from Taxus × media cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activities of DMGF on the metastatic processes of melanoma c... |
SARS in Canada: Lessons Learned for the Blood Operator | |
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators | Interferon-stimulated gene 15 (ISG15) encodes an ubiquitin-like protein that covalently conjugates protein. Protein modification by ISG15 (ISGylation) is known to inhibit the replication of many viruses. However, studies on the viral targets and viral strategies to regulate ISGylation-mediated antiviral responses are l... |
CD8(+) T-Cells as Immune Regulators of Multiple Sclerosis | The vast majority of studies regarding the immune basis of MS (and its animal model, EAE) have largely focused on CD4(+) T-cells as mediators and regulators of disease. Interestingly, CD8(+) T-cells represent the predominant T-cell population in human MS lesions and are oligoclonally expanded at the site of pathology. ... |
Psycho-Emotional Approach to the Psychological Distress Related to the COVID-19 Pandemic in Spain: A Cross-Sectional Observational Study | Anxiety, depression, and stress are common and expected reactions to the coronavirus disease (COVID-19) pandemic The objective of this study is to analyze psychological distress in a sample of Spanish population, identifying the predictive nature of the information received, the preventive measures taken, level of conc... |
A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance | BACKGROUND: Chickens are susceptible to infection with a limited number of Influenza A viruses and are a potential source of a human influenza pandemic. In particular, H5 and H7 haemagglutinin subtypes can evolve from low to highly pathogenic strains in gallinaceous poultry. Ducks on the other hand are a natural reserv... |
Tanzania – Coronavirus Concerns | |
Engineering Infectious cDNAs of Coronavirus as Bacterial Artificial Chromosomes | The construction of coronavirus (CoV) infectious clones had been hampered by the large size of the viral genome (around 30 kb) and the instability of plasmids carrying CoV replicase sequences in Escherichia coli. Several approaches have been developed to overcome these problems. Here we describe the engineering of CoV ... |
Chances and challenges in China | |
36 Group A Streptococcus | |
Chest CT in COVID-19 pneumonia: a review of current knowledge | Abstract The current COVID-19 pandemic has highlighted the essential role of chest computed tomography (CT) examination in patient triage in the emergency departments, allowing them to be referred to "COVID" or "non-COVID" wards. Initial chest CT examination must be performed without intravenous administration of iodin... |
Calf Clinical Model of Cryptosporidiosis for Efficacy Evaluation of Therapeutics | Cryptosporidiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a moderate-to-severe diarrheal disease now recognized as one of the leading causes of morbidity and mortality in livestock globally, and in humans living in resource-limited parts of the world, particularly those with AIDS or malnourished... |
Patient Characteristics of VA Telehealth Users During Hurricane Harvey | Introduction: Research on patient characteristics of telehealth users is relatively new. More studies are needed to understand the characteristics of telehealth users during disasters. This study attempts to bridge this gap and examines patient characteristics of telehealth users compared with nontelehealth users at th... |
Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017 | BACKGROUND: The Respiratory Syncytial Virus (RSV) A genotype ON1, which was first detected in Ontario (Canada) in 2010/11, appeared in Germany in 2011/12. Preliminary observations suggested a higher clinical severity in children infected with this new genotype. We investigated spread and disease severity of RSV-A ON1 i... |
Wissenschaft Aktuell | Bei manchen Patienten äußert sich eine SARS-CoV-2-Infektion zunächst durch kardiovaskuläre Symptome Erste Studien zeigen auch: Die Erkrankung ist nicht nur mit respiratorischen Schädigungen, sondern auch mit Herzschäden assoziiert Forscher um Dr Ying-Ying Zheng, Zhengzhou/China, vermuten, dass die durch SARS-CoV-2 veru... |
Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 | We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carnival season, distinct v... |
SARS-CoV-2 and Prostatitis: dangerous relationship for male sexual and reproductive health | |
COVID-19: air pollution remains low as people stay at home | Coronavirus diseases 2019 (COVID-19) is transmitted worldwide in over a very short time, as it was originated in late 2019 from Wuhan city, China. To reduce the possible effects due to COVID-19, some sort of lockdown activities have been applied in many countries. In this regard, the outcomes reported bonus benefits to... |
The new oil? The geopolitics and international governance of hydrogen | While most hydrogen research focuses on the technical and cost hurdles to a full-scale hydrogen economy, little consideration has been given to the geopolitical drivers and consequences of hydrogen developments. The technologies and infrastructures underpinning a hydrogen economy can take markedly different forms, and ... |
Orthopoxvirus DNA in Eurasian Lynx, Sweden | Cowpox virus, which has been used to protect humans against smallpox but may cause severe disease in immunocompromised persons, has reemerged in humans, domestic cats, and other animal species in Europe. Orthopoxvirus (OPV) DNA was detected in tissues (lung, kidney, spleen) in 24 (9%) of 263 free-ranging Eurasian lynx ... |
Covid‐19: Ethical Challenges for Nurses | The Covid‐19 pandemic has highlighted many of the difficult ethical issues that health care professionals confront in caring for patients and families. The decisions such workers face on the front lines are fraught with uncertainty for all stakeholders. Our focus is on the implications for nurses, who are the largest g... |
Epidemic strain YC2014 of porcine epidemic diarrhea virus could provide piglets against homologous challenge | BACKGROUND: Porcine epidemic diarrhea virus (PEDV) is the main causative agent of porcine epidemic diarrhea (PED). Since December 2010, a large-scale outbreak of diarrhea has been observed in swine farms in China. Accumulated evidence indicates that this large-scale outbreak of diarrhea were caused by highly virulent P... |
The Anesthesia Management of the First Lung Transplant Case for Patient with COVID-19 Respiratory Failure | |
Role of respirators in controlling the spread of novel coronavirus (COVID‐19) amongst dental healthcare providers: a review | During the ongoing COVID‐19 pandemic, healthcare professionals are at the forefront of managing the highly infectious coronavirus. As the most common route of transmission is via aerosols and droplet inhalation, it is critical for healthcare workers to have the correct personal protective equipment (PPE) including gown... |
MH coalition asks government for needed protective gear | A mental health coalition on April 1 in urged the federal government to provide personal protection equipment (PPE) to all behavioral health care professionals on the frontlines of the COVID‐19 pandemic. The letter, signed by the National Council for Behavioral Health, the National Alliance on Mental Illness, Mental He... |
A Simple and Multiplex Loop-Mediated Isothermal Amplification (LAMP) Assay for Rapid Detection of SARS-CoV | The current diagnosis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) relies on laboratory-based tests since its clinical features are nonspecific, unlike other respiratory pathogens. Therefore, the development of a rapid and simple method for on-site detection of SARS-CoV is crucial for the iden... |
Inverse folding of RNA pseudoknot structures | BACKGROUND: RNA exhibits a variety of structural configurations. Here we consider a structure to be tantamount to the noncrossing Watson-Crick and G-U-base pairings (secondary structure) and additional cross-serial base pairs. These interactions are called pseudoknots and are observed across the whole spectrum of RNA f... |
Integrated biological–behavioural surveillance in pandemic-threat warning systems | Economically and politically disruptive disease outbreaks are a hallmark of the 21st century. Although pandemics are driven by human behaviours, current surveillance systems for identifying pandemic threats are largely reliant on the monitoring of disease outcomes in clinical settings. Standardized integrated biologica... |
Morele stress in tijden van corona | Wat is goede zorg als deze overspoeld wordt door covid-patiënten? Zorgverleners raken soms gefrustreerd als zij niet kunnen voldoen aan hun eigen ethische normen. ‘Praat erover, en accepteer dat je soms niet meer kunt doen dan je hebt gedaan.’ |
All Known Human Rhinovirus Species Are Present in Sputum Specimens of Military Recruits During Respiratory Infection | Human rhinoviruses (HRV) are known to cause common cold as well as more complicated respiratory infections. HRV species -A, -B and -C have all been associated with lower respiratory infections and exacerbations of asthma. However, the type distribution of strains connected to different kinds of lower respiratory condit... |
Deadly combination of Vaping-lnduced lung injury and Influenza: case report | BACKGROUND: E-cigarette and vaping use-associated acute lung injury (EVALI) has been recently recognized as a complication in individuals who use vaping devices. Another consideration is that EVALI may have an adverse influence on the outcome of intercurrent respiratory infections. We document this deadly combination i... |
Respiratory viruses in children attending Kindergarten | |
Complicated Grief: What to Expect After the Coronavirus Pandemic | The COVID-19 pandemic is one of the worst public health crises in a century, with an expected amount of deaths of several million worldwide and an even bigger number of bereaved people left behind. Although the consequences of this crisis are still unknown, a significant number of bereaved people will arguably develop ... |
Management of bilateral uveitis in a Toxoplasma gondii‐seropositive cat with histopathologic evidence of fungal panuveitis | A 5‐year‐old, neutered male Domestic Short‐haired cat was referred with a 5‐month history of anterior uveitis and cataract in the right eye. Clinical examination confirmed anterior uveitis and immature cataract in the right eye and chorioretinitis in the left eye. Ocular ultrasound showed a retinal detachment in the ri... |
Population- and Variant-Based Genome Analyses of Viruses from Vaccine-Derived Rabies Cases Demonstrate Product Specific Clusters and Unique Patterns | Rabies in wildlife has been successfully controlled in parts of Europe and North America using oral rabies vaccination, i.e., the distribution of baits containing live-attenuated virus strains. Occasionally, these vaccines caused vaccine virus-induced rabies cases. To elucidate the mechanisms of genetic selection and t... |
Detection of Influenza and Other Respiratory Viruses Carried Out in the Influenza Project – Monitoring Vaccine Effectiveness (I-MOVE) | The project Influenza Vaccine Effectiveness-Monitoring (I-MOVE) is part of the European research carried out by the ECDC (European Center for Disease Prevention and Control), aimed at monitoring the effectiveness of vaccination in Europe during the growing incidence of flu and influenza-like illnesses in the coming epi... |
Investigating ICT using problem-based learning in face-to-face and online learning environments | Abstract This article reports on the design, implementation and evaluation of a module in the MEd (Business) in the Faculty of Education at the University of Hong Kong in which an explicit problem-based learning (PBL) approach was used to investigate the challenges associated with the adoption and use of information an... |
Translational research in infectious disease: current paradigms and challenges ahead | In recent years, the biomedical community has witnessed a rapid scientific and technological evolution following the development and refinement of high-throughput methodologies. Concurrently and consequentially, the scientific perspective has changed from the reductionist approach of meticulously analyzing the fine det... |
Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases | |
The “Big Five” Lung Diseases in CoViD-19 Pandemic – a Google Trends analysis | |
DO HUMAN T‐LYMPHOTROPHIC VIRUSES (HTLVs) AND OTHER ENVELOPED VIRUSES INDUCE AUTOIMMUNITY IN MULTIPLE SCLEROSIS? | A virally induced autoimmune reaction may be important in the pathogenesis of multiple sclerosis. The role that glycolipids and myelin basic protein presented to the virus may play in this process is considered. The most likely cells to be the source of autoantigens are neurons, myelin and oligodendrocytes. Viral infec... |
Freedom and Stock Market Performance during Covid-19 Outbreak | • The number of Covid-19 pandemic cases per million has significant negative effects on global financial markets. • The adverse effects of the coronavirus on the stock markets are less in freer countries. In other words, the stock markets of less-free countries are affected more by the same size of increase in the numb... |
Molecular characterization of a canine coronavirus NA/09 strain detected in a dog’s organs | In the present study, the detection of a pantropic canine coronavirus (CCoV) strain in a dog with lethal diarrhoea is reported. RT-PCR and real-time RT-PCR assays were used for the detection, characterization and quantitation of CCoV. Sequence and phylogenetic analysis of the CCoV NA/09 revealed a high degree of sequen... |
Psychometric Properties of a Spanish Version of the Fear of COVID-19 Scale in General Population of Lima, Peru | The current pandemic of the novel coronavirus COVID-19 has increased the anxiety and fear experienced by many. The main objective of this study was to analyze the psychometric properties of the Spanish-translated version of the Fear of COVID-19 Scale (FCV-19S) using a sample of population in Peru. This is a cross-secti... |
Respiratory Virus Infection During Pregnancy: Does It Matter? | |
Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade | Here, we review the most recent findings on the effects of SARS-CoV-2 infection on kidney diseases, including acute kidney injury, and examine the potential effects of ARBs on the outcomes of patients with COVID-19. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, p... |
Imagining what education can be post-COVID-19 | This Viewpoint argues that the COVID-19 crisis offers a unique chance to imagine more equitable societies and education systems. It is also a call to action, to take meaningful action to bring about that desired future. |
Assessing climate-induced agricultural vulnerable coastal communities of Bangladesh using machine learning techniques | Abstract The agricultural arena in the coastal regions of South-East Asian countries is experiencing the mounting pressures of the adverse effects of climate change. Controlling and predicting climatic factors are difficult and require expensive solutions. The study focuses on identifying issues other than climatic fac... |
Topology Engineering of Proteins in Vivo Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stability | [Image: see text] Recombinant proteins are traditionally limited to linear configuration. Herein, we report in vivo protein topology engineering using highly efficient, mechanically interlocking SpyX modules named AXB and BXA. SpyX modules are protein domains composed of p53dim (X), SpyTag (A), and SpyCatcher (B). The ... |
Retrospective study, full‐length genome characterization and evaluation of viral infectivity and pathogenicity of chimeric porcine deltacoronavirus detected in Vietnam | Increased evidence of porcine deltacoronavirus (PDCoV) causing diarrhoea in pigs has been reported in several countries worldwide. The virus has currently evolved into three separated groups including US, China and Southeast Asia (SEA) groups. In Vietnam, PDCoV was first reported in 2015. Based on phylogenetic analyses... |
ELDER ABUSE IN THE COVID‐19 ERA | |
Vaso‐occlusive crisis and acute chest syndrome in sickle cell disease due to 2019 novel coronavirus disease (COVID‐19) | |
Novel smacoviruses identified in the faeces of two wild felids: North American bobcat and African lion | Smacoviruses are small circular single-stranded DNA viruses that appear to be prevalent in faeces of a range of animals and have also been found in a few insect species. In this study, we report the first viral genomes from faeces of free-roaming wild felids on two continents. Two smacoviruses were recovered from the f... |
Loss of Paramedic Availability in an Urban Emergency Medical Services System during a Severe Acute Respiratory Syndrome Outbreak | Objectives: To describe the loss of paramedic availability to Toronto Emergency Medical Services during a biphasic (SARS‐1 and SARS‐2) outbreak of severe acute respiratory syndrome (SARS). Methods:During the SARS outbreak, a dedicated paramedic surveillance and quarantine program was developed. The authors determined t... |
Challenges in Tuberculosis Clinical Trials in the Face of the COVID-19 Pandemic: A Sponsor’s Perspective | The COVID-19 pandemic has caused unforeseen and extreme changes in societal and health system functioning not previously experienced in most countries in a lifetime. The impact of the pandemic on clinical trials can be especially profound given their complexities and operational requirements. The STREAM Clinical Trial ... |
Impact of the implementation of a respiratory TaqMan® Array Card syndromic based diagnostic approach on clinical management of pediatric inpatients | |
Opciones Terapéuticas En El Manejo De Covid-19 Grave: Una Perspectiva De Reumatología | Resumen El inicio del nuevo coronavirus humano del síndrome respiratorio agudo grave (SARS-Cov-2) en Wuhan, China, ha desencadenado un brote respiratorio mundial (COVID-19). El síndrome de insuficiencia respiratoria agua (SIRA), el fallo multiorgánico y eventos trombóticos están entre las causas que llevan a la muerte ... |
Asymptomatic Shedding of Respiratory Virus among an Ambulatory Population across Seasons | Most observation of human respiratory virus carriage is derived from medical surveillance; however, the infections documented by this surveillance represent only a symptomatic fraction of the total infected population. As the role of asymptomatic infection in respiratory virus transmission is still largely unknown and ... |
Emerging from the COVID-19 outbreak: For a methodology of deconfinement that respects the human being | |
COVID-19 and diabetes mellitus: A need for prudence in elderly patients from a pooled analysis | OBJECTIVE: The objective of this study was to evaluate the pooled estimate of diabetes prevalence in young (<50 years) versus elderly (>50 years) COVID-19 cohorts. METHODS: Studies published between December-2019 and March-2020 reporting demographic and clinical characteristics of COVID-19 cases were identified. A tota... |
Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19 | Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus disease 2019 (COVID-19) also tested positive for SARS-CoV-2 (Rivett et al., 2020). Here, we... |
Evolving towards professionalism in emergency nursing in Hong Kong | This paper aims to share with the readers about the experience of emergency nursing development and related roles in Hong Kong. The roles of emergency nurses are evolving and triggered by three major historical milestones. The three milestones consist of: (1) Transition of nursing education from hospital training to nu... |
Circular Economy as a COVID-19 Cure? |
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