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PMID:21473 | Partial characterization of epididymal 5 alpha reductase in the rat. | Epididymal 5alpha reductase activity was found distitributed in the crude nuclear fraction (44 percent) and microsomal fraction (41 percent). Spermatozoa contaminating the nuclear preparation accounted for only 3 percent of its activity. There were no regional differences in the distribution of total 5alpha reductase a... | Partial characterization of epididymal 5 alpha reductase in the rat. Epididymal 5alpha reductase activity was found distitributed in the crude nuclear fraction (44 percent) and microsomal fraction (41 percent). Spermatozoa contaminating the nuclear preparation accounted for only 3 percent of its activity. There were no... | [
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PMID:21474 | Oxidative metabolism and de-ethynylation of 17alpha-ethynylestradiol by baboon liver microsomes. | Incubations of tritiated 17alpha-ethynylestradiol (EE2) with liver explants of baboon and mouse showed the primate species to be more efficient in the removal of the ethynyl group. Liver microsomes from sexually immature male and female baboons were then incubated with tritiated EE2 and estradiol (E2). Each hormone bou... | Oxidative metabolism and de-ethynylation of 17alpha-ethynylestradiol by baboon liver microsomes. Incubations of tritiated 17alpha-ethynylestradiol (EE2) with liver explants of baboon and mouse showed the primate species to be more efficient in the removal of the ethynyl group. Liver microsomes from sexually immature ma... | [
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PMID:21478 | [Triggering and regulatory mechanisms of ciliary motion in the ctenophore Bolinopsis. III. Electric excitability and inherent contractility of ciliated cells]. | Rhythmical electrostimulation is able to produce in a tissue strip of Bolinopsis series of beats of combs-plates. However, the beat frequency, within one series, is only poorly controlled by electrical stimuli. Isolated comb-plate cells with a cilium cut off maintain rhythmical contractions stimulated both mechanically... | [Triggering and regulatory mechanisms of ciliary motion in the ctenophore Bolinopsis. III. Electric excitability and inherent contractility of ciliated cells]. Rhythmical electrostimulation is able to produce in a tissue strip of Bolinopsis series of beats of combs-plates. However, the beat frequency, within one series... | [
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PMID:21481 | Splenic-gonadal fusion and adrenal cortical rest associated with bilateral cryptorchism. | A patient with bilateral cryptorchism had ectopic splenic tissue adherent to his left testicle and an adrenal cortical rest adherent to his right testicle. The embrylogic basis for these disorders is discussed and the literature reviewed. | Splenic-gonadal fusion and adrenal cortical rest associated with bilateral cryptorchism. A patient with bilateral cryptorchism had ectopic splenic tissue adherent to his left testicle and an adrenal cortical rest adherent to his right testicle. The embrylogic basis for these disorders is discussed and the literature re... | [
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PMID:21482 | Uropharmacology: part VI. Parasympathetic depressants. | A discussion of the various parasympathetic depressants is presented. Belladonna alkaloids include atropine, the prototype, and scopolamine. Synthetic drugs include quaternary ammonium compounds with antimuscarinic activity such as methantheline, propantheline, and other drugs such as isopropamide, pipenzolate methylbr... | Uropharmacology: part VI. Parasympathetic depressants. A discussion of the various parasympathetic depressants is presented. Belladonna alkaloids include atropine, the prototype, and scopolamine. Synthetic drugs include quaternary ammonium compounds with antimuscarinic activity such as methantheline, propantheline, and... | [
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PMID:21483 | [Method of stabilizing ketamine anesthesia]. | The authors eliminated the disavantages of intravenous ketamine anesthesia, interfering with its wide use (hypertension, tachicardia, hypersalivation, diplopia etc.) by means of preliminary ganglionic blockade. Clinical studies of ketamine anesthesis with ganglionic blockade and without the latter illustrated the advan... | [Method of stabilizing ketamine anesthesia]. The authors eliminated the disavantages of intravenous ketamine anesthesia, interfering with its wide use (hypertension, tachicardia, hypersalivation, diplopia etc.) by means of preliminary ganglionic blockade. Clinical studies of ketamine anesthesis with ganglionic blockade... | [
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PMID:21480 | [Effect of carbonic acid concentration in blood on content of keto-acids and redox state of nicotinamide coenzymes in rabbit tissues]. | A rise in the level of carbonic acid in animal blood at practically unchanged pH causes an increase in the value of free [NAD+]/[NADH] and [NADP+]/[NADPH] ratios in the liver cells cytoplasm. The increase in the oxidizing power of the liver cells cytoplasm is observed against a background of a rise in both the total le... | [Effect of carbonic acid concentration in blood on content of keto-acids and redox state of nicotinamide coenzymes in rabbit tissues]. A rise in the level of carbonic acid in animal blood at practically unchanged pH causes an increase in the value of free [NAD+]/[NADH] and [NADP+]/[NADPH] ratios in the liver cells cyto... | [
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PMID:21486 | Acid elution of blood group antibodies from intact erythrocytes. | Human IgM and IgG antibodies against blood group antigens (A, B, D, C, c, E, e, Fya, K), autoantibodies and mouse IgM and IgG antibodies against sheep erythrocytes have been eluted from intact human and sheep red cells by glycine-HCl buffer, pH 3.0. The yield of human antibodies was higher with acid than with heat and ... | Acid elution of blood group antibodies from intact erythrocytes. Human IgM and IgG antibodies against blood group antigens (A, B, D, C, c, E, e, Fya, K), autoantibodies and mouse IgM and IgG antibodies against sheep erythrocytes have been eluted from intact human and sheep red cells by glycine-HCl buffer, pH 3.0. The y... | [
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PMID:21484 | [Relationship between glycolysis and pentose cycle intensity and thrombocyte aggregation induced by ADP in man]. | Aggregation of thrombocytes, caused by ADP, affected the rate of anaerobic breakdown of carbohydrates due to inhibition of the glucose degradation, while the rate of lactate formation was not distinctly altered. Content of NAD was decreased simultaneously with an increase in content of NADP; the activity of glucose-6-p... | [Relationship between glycolysis and pentose cycle intensity and thrombocyte aggregation induced by ADP in man]. Aggregation of thrombocytes, caused by ADP, affected the rate of anaerobic breakdown of carbohydrates due to inhibition of the glucose degradation, while the rate of lactate formation was not distinctly alte... | [
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PMID:21489 | [Pathophysiology of lipolysis in human adipose tissue (author's transl)]. | Lipolysis in human adipose tissue was measured as glycerol release in isolated fat cells and in adipose tissue homogenates. In isolated fat cells lipolysis proceeded optimally at pH 7.4, was stimulated 3.5 fold by noradrenaline and was not influenced by serum or protamine. In adipose tissue homogenates lipolysis was st... | [Pathophysiology of lipolysis in human adipose tissue (author's transl)]. Lipolysis in human adipose tissue was measured as glycerol release in isolated fat cells and in adipose tissue homogenates. In isolated fat cells lipolysis proceeded optimally at pH 7.4, was stimulated 3.5 fold by noradrenaline and was not influe... | [
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PMID:21485 | [Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]. | Content of free glutamine and the activity of glutamine synthetase and glutamine transaminase were studied in practically healthy persons and in patients with chronic atrophic gastritis, ulcerous disease, polyposis and with gastric carcinoma. The enzymatic activity was estimated in the areas of ulcerous impairment, of ... | [Specificity of glutamine metabolism in pre-tumorous diseases and cancer of the human stomach]. Content of free glutamine and the activity of glutamine synthetase and glutamine transaminase were studied in practically healthy persons and in patients with chronic atrophic gastritis, ulcerous disease, polyposis and with ... | [
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PMID:21494 | [On characterization of lipoxygenase from barley (author's transl)]. | Lipoxygenase from brewing barley of Nordbaden has optimum activity at alkaline pH and predominantly forms 9-hydroperoxy-10-trans, 12-cis-octadecadienoic acid (9-LHPO) from linoleic acid. While at pH 7 90% 9-LHPO is produced, its proportions drops during incubation at more alkaline pH (pH 7,75) to 70%. This positional s... | [On characterization of lipoxygenase from barley (author's transl)]. Lipoxygenase from brewing barley of Nordbaden has optimum activity at alkaline pH and predominantly forms 9-hydroperoxy-10-trans, 12-cis-octadecadienoic acid (9-LHPO) from linoleic acid. While at pH 7 90% 9-LHPO is produced, its proportions drops duri... | [
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PMID:21495 | [The idiopathic respiratory distress syndrome from the obstetrical point of view]. | Frequency of idiopathic respiratory distress syndrome (IRDS) of low birth weight children was examined over 15 years (1960 to 1975) in the Frauenklinik of the Ernst-Moritz-Arndt-University of Greifswald. Possible pathogenetic risk factors were proofed. The validity of the Apgar-score and blood gas analyses for the deve... | [The idiopathic respiratory distress syndrome from the obstetrical point of view]. Frequency of idiopathic respiratory distress syndrome (IRDS) of low birth weight children was examined over 15 years (1960 to 1975) in the Frauenklinik of the Ernst-Moritz-Arndt-University of Greifswald. Possible pathogenetic risk factor... | [
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PMID:21496 | [Induction of labor with prostaglandin F 2 alpha (a comparative study using oxytocin and prostaglandin)]. | The authors investigated the effectiveness of prostaglandin F2alpha administered by intravenous drop infusion to induce labour. They compared their results with those obtained in oxytocin-induced labour. They determined that prostaglandin F2alpha can without any danger be administered in the induction of labour. The pr... | [Induction of labor with prostaglandin F 2 alpha (a comparative study using oxytocin and prostaglandin)]. The authors investigated the effectiveness of prostaglandin F2alpha administered by intravenous drop infusion to induce labour. They compared their results with those obtained in oxytocin-induced labour. They deter... | [
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PMID:21497 | [Behavior of various serum and urinary peptidases in pregnancy]. | The investigations were carried out on activities of leucinearylamidase (LAP) and (GGTP) gammaglutamyltranspeptidase in serum and urine of women with physiological and prolonged pregnancy. The results shown on pathological increase of LAP-activity in serum and increase excretion of both enzymes in to the urine during p... | [Behavior of various serum and urinary peptidases in pregnancy]. The investigations were carried out on activities of leucinearylamidase (LAP) and (GGTP) gammaglutamyltranspeptidase in serum and urine of women with physiological and prolonged pregnancy. The results shown on pathological increase of LAP-activity in seru... | [
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PMID:21499 | [Relationship between the incidence of neurologic complications following smallpox vaccination and the generation and infectious activity of vaccine from strain L-IVP]. | A strictly controlled epidemiological trial was applied to the study of the incidence of neurological complications in children inoculated with vaccine from the L-IVP strain of the 2nd, 3rd, and 5th passages (generations). To ascertain a possible connection between the neuropathogenicity with the infectious activity th... | [Relationship between the incidence of neurologic complications following smallpox vaccination and the generation and infectious activity of vaccine from strain L-IVP]. A strictly controlled epidemiological trial was applied to the study of the incidence of neurological complications in children inoculated with vaccine... | [
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PMID:21500 | [Role of autoimmune processes in the pathogenesis of post-vaccinal lesions of the nervous system]. | Subcutaneous sensitization of guinea pigs with -vaccine, and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies, whereas subcutaneous or intradermal immunization of the animals with liver viral vaccines was not accompanied by the formation of autoantibodies and deve... | [Role of autoimmune processes in the pathogenesis of post-vaccinal lesions of the nervous system]. Subcutaneous sensitization of guinea pigs with -vaccine, and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies, whereas subcutaneous or intradermal immunization of th... | [
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PMID:21501 | Pseudomonas cytochrome c peroxidase. XIII. pH-denaturation of the enzyme. | The effect of pH on the oxidized Pseudomonas cytochrome c peroxidase molecule was studied by measuring the peroxidatic activity, the sedimentation velocity, the circular dichroic spectra in the far UV and Soret regions, and the optical absorption spectra of the enzyme in the pH range 2.5-13.0 at a constant ionic streng... | Pseudomonas cytochrome c peroxidase. XIII. pH-denaturation of the enzyme. The effect of pH on the oxidized Pseudomonas cytochrome c peroxidase molecule was studied by measuring the peroxidatic activity, the sedimentation velocity, the circular dichroic spectra in the far UV and Soret regions, and the optical absorption... | [
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PMID:21498 | [Interneuronal synapses with electrical and chemical mechanisms of transmission and the evolution of the central nervous system]. | It becomes increasingly evident that not only chemical but also electrotonic synapses are characteristic feature of the vertebrate brain. Experiments carried out on the isolated perfused central nervous system of lampreys and frogs have shown that in cyclostomes spinal motoneurons receive at least 4 different electroto... | [Interneuronal synapses with electrical and chemical mechanisms of transmission and the evolution of the central nervous system]. It becomes increasingly evident that not only chemical but also electrotonic synapses are characteristic feature of the vertebrate brain. Experiments carried out on the isolated perfused cen... | [
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PMID:21503 | Correlation of pituitary and testicular responses to stimulation tests in cryptorchid children. | LH-RH test and HCG stimulation test were performed in 154 cryptorchid boys aged 1 month to 15 years (64 unilateral and 90 bilateral). Basal plasma LH levels and LH response to LH-RH were significantly lower from infancy to early puberty in cryptorchids compared with controls. Basal FSH levels and FSH response to LH-RH ... | Correlation of pituitary and testicular responses to stimulation tests in cryptorchid children. LH-RH test and HCG stimulation test were performed in 154 cryptorchid boys aged 1 month to 15 years (64 unilateral and 90 bilateral). Basal plasma LH levels and LH response to LH-RH were significantly lower from infancy to e... | [
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PMID:21504 | Comparison of a new antihistamine HC 20-511 with cyproheptadine (Periactin) in chronic urticaria. | The effect and tolerance of a new antihistamine, HC 20-511, in daily doses of 2 and 4 mg was compared with cyproheptadine (Periactin) 8 mg daily in 50 cases of chronic urticaria. HC 20-511 4 mg daily proved to be the most effective, rapid and long-lasting. HC 20-511 had less sedative effect than cyproheptadine, but bot... | Comparison of a new antihistamine HC 20-511 with cyproheptadine (Periactin) in chronic urticaria. The effect and tolerance of a new antihistamine, HC 20-511, in daily doses of 2 and 4 mg was compared with cyproheptadine (Periactin) 8 mg daily in 50 cases of chronic urticaria. HC 20-511 4 mg daily proved to be the most ... | [
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PMID:21505 | Action of enflurane (Ethrane) on the neuromusclar block induced by AH 8165 D. | The neuromuscular block induced by AH 8165 D, a new non-depolarizing muscle relaxant, has been studied in two series of anesthetised patients. All the anesthetics were induced by Althesin, and intubations performed under local anesthesia. The first series of 15 patients received only 75% nitrous oxide and 25% oxygen ... | Action of enflurane (Ethrane) on the neuromusclar block induced by AH 8165 D. The neuromuscular block induced by AH 8165 D, a new non-depolarizing muscle relaxant, has been studied in two series of anesthetised patients. All the anesthetics were induced by Althesin, and intubations performed under local anesthesia. T... | [
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PMID:21506 | Duration of action of analgesic supplements to anesthesia. A double-blind comparison between morphine, fentanyl and sulfentanil. | In a double-blind trial, in a total of 45 patients, sulfentanil was compared with fentanyl and morphine in equipotent doses, as a narcotic supplement to anesthesia. Initially, morphine was shown to have a significantly longer duration of effect than fentanyl and sulfentanil, which for the first 3 doses had similar dur... | Duration of action of analgesic supplements to anesthesia. A double-blind comparison between morphine, fentanyl and sulfentanil. In a double-blind trial, in a total of 45 patients, sulfentanil was compared with fentanyl and morphine in equipotent doses, as a narcotic supplement to anesthesia. Initially, morphine was s... | [
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PMID:21507 | Possible pathogenesis of Huntington's chorea and a new approach to treatment. | Recent identification of glutamate as a transmitter in neocortical efferents and discovery of toxic effects of excessive amounts of extra-cellular glutamate or its analogues on some brain neurons offer an explanation of the pathogenesis of Huntington's chorea. Cell death as well as consequent biochemical changes and cl... | Possible pathogenesis of Huntington's chorea and a new approach to treatment. Recent identification of glutamate as a transmitter in neocortical efferents and discovery of toxic effects of excessive amounts of extra-cellular glutamate or its analogues on some brain neurons offer an explanation of the pathogenesis of Hu... | [
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PMID:21508 | Acid production from Lycasin, maltitol, sorbitol and xylitol by oral streptococci and lactobacilli. | The acid production from maltitol was compared with the acid production from hydrogenated starch hydrolysate (Lycasin), sorbitol and xylitol by a number of oral strains and reference strains of Streptococcus mutans, S. sanguis, S. salivarius, S. mitior, S. milleri, S. faecalis, S. faecium, S. avium, Lactobacillus casei... | Acid production from Lycasin, maltitol, sorbitol and xylitol by oral streptococci and lactobacilli. The acid production from maltitol was compared with the acid production from hydrogenated starch hydrolysate (Lycasin), sorbitol and xylitol by a number of oral strains and reference strains of Streptococcus mutans, S. s... | [
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PMID:21511 | [Cogan's syndrome]. | Since Cogan described his first case in 1945, about 50 cases have been published in the world literature, A 23 year old patient who suffered from this disease led us to make a detailed study of previous publications. The cochleo-vestibular, the etiological and the ophtalmical aspects of the case were studied, and, also... | [Cogan's syndrome]. Since Cogan described his first case in 1945, about 50 cases have been published in the world literature, A 23 year old patient who suffered from this disease led us to make a detailed study of previous publications. The cochleo-vestibular, the etiological and the ophtalmical aspects of the case wer... | [
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PMID:21512 | Relapsing polychondritis. A clinical, pathologic-anatomic and histochemical study of 2 cases. | A 57-year-old man and a 70-year-old woman with relapsing polychondritis are reported. The man, suffering from arthralgias, respiratory obstruction, external ear and sanddle-nose deformities, conjunctivitis and irido-cyclitis, died after 4 years from airway obstruction because of tracheal and bronchial collapse. The wom... | Relapsing polychondritis. A clinical, pathologic-anatomic and histochemical study of 2 cases. A 57-year-old man and a 70-year-old woman with relapsing polychondritis are reported. The man, suffering from arthralgias, respiratory obstruction, external ear and sanddle-nose deformities, conjunctivitis and irido-cyclitis, ... | [
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PMID:21509 | A dental splint for use during peroral endoscopy. | Damage to teeth is a well known complication of peroral endoscopy. A case is described in which potentially fatal complications of such damage occurred. This spurred on the development of a dental splint as an aid in the prevention of such damage. This splint is described, and evidence for the beneficial results of its... | A dental splint for use during peroral endoscopy. Damage to teeth is a well known complication of peroral endoscopy. A case is described in which potentially fatal complications of such damage occurred. This spurred on the development of a dental splint as an aid in the prevention of such damage. This splint is describ... | [
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PMID:21513 | Differetial staining of glycosaminoglycans, utilizing bacterial chondroitinase and chondrosulphatase. | A histochemical method for the differentiation of glucosaminoglycans, utilizing bacterial chondroitinase ABC and chondro-4- and -6 sulphatases, and staining with Alcian blue, is presented. The method is applied on human tissues with known glucosaminoglycan content (ganglion cyst, umbilical cord, foetal cartilage, adult... | Differetial staining of glycosaminoglycans, utilizing bacterial chondroitinase and chondrosulphatase. A histochemical method for the differentiation of glucosaminoglycans, utilizing bacterial chondroitinase ABC and chondro-4- and -6 sulphatases, and staining with Alcian blue, is presented. The method is applied on huma... | [
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PMID:21517 | Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. | The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactiv... | Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in fo... | [
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PMID:21518 | Serum inorganic phosphate in middle-aged men. I. Inverse relation to body weight. | Serum inorganic phosphate was determined in 752 men born in 1926. An inverse correlation was found between serum inorganic phosphate levels and body weight. Other parameters of possible relevance to this finding, such as serum calcium, serum albumin, serum lambda-glutamyltransferase, and the occurrence of upper gastroi... | Serum inorganic phosphate in middle-aged men. I. Inverse relation to body weight. Serum inorganic phosphate was determined in 752 men born in 1926. An inverse correlation was found between serum inorganic phosphate levels and body weight. Other parameters of possible relevance to this finding, such as serum calcium, se... | [
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PMID:21534 | Introduction of artificial crosslinks into proteins. | In this chapter, we present a brief overview of the current status of protein crosslinking technology. An attempt is made to compare the natural crosslinks and natural crosslinking agents to the artificial ones, and a brief section is devoted to the potential use of enzymes (transglutaminase and peroxidase) as crosslin... | Introduction of artificial crosslinks into proteins. In this chapter, we present a brief overview of the current status of protein crosslinking technology. An attempt is made to compare the natural crosslinks and natural crosslinking agents to the artificial ones, and a brief section is devoted to the potential use of ... | [
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PMID:21535 | Comparison of hydrophobic and strongly hydrophilic cleavable crosslinking reagents in intermolecular bond formation in aggregates of proteins or protein-RNA. | Most of the bifunctional reagents in protein chemistry possess a strongly hydrophobic backbone, derived from aliphatic or aromatic hydrocarbons. Even bifunctionals of more than 30 A in length of this sort form intramolecular bridges preferentially. In recent years, the intermolecular crosslinking of physiological prote... | Comparison of hydrophobic and strongly hydrophilic cleavable crosslinking reagents in intermolecular bond formation in aggregates of proteins or protein-RNA. Most of the bifunctional reagents in protein chemistry possess a strongly hydrophobic backbone, derived from aliphatic or aromatic hydrocarbons. Even bifunctional... | [
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PMID:21536 | Comparison of wool reactions with selected mono and bifunctional reagents. | The molecular structure of wool is discussed in relation to chemical reactivity and the role of disulfide crosslinks. Ideal characteristics of an effective medium (e.g. dimethylformamide) for modifying wool include the ability to penetrate and swell wool without interfering with reagents used. The extent of reaction ... | Comparison of wool reactions with selected mono and bifunctional reagents. The molecular structure of wool is discussed in relation to chemical reactivity and the role of disulfide crosslinks. Ideal characteristics of an effective medium (e.g. dimethylformamide) for modifying wool include the ability to penetrate and... | [
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PMID:21537 | Kinetic studies of immobilized alpha-chymotrypsin in apolar solvents. | The mechanism of alpha-chymotrypsin action has been probed by extending studies of native chymotrypsin to immobilized chymotrypsin, where the organic content of the solution can be raised to much higher levels and thus one can explicitly look at the role of water. When one does this, one finds that water only appears i... | Kinetic studies of immobilized alpha-chymotrypsin in apolar solvents. The mechanism of alpha-chymotrypsin action has been probed by extending studies of native chymotrypsin to immobilized chymotrypsin, where the organic content of the solution can be raised to much higher levels and thus one can explicitly look at the ... | [
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PMID:21538 | Factors affecting cyanoborohydride reduction of aromatic Schiff's bases in proteins. | Reductive alkylation of bovine serum albumin (BSA) and wool by a aromatic aldehydes and sodium cyanoborohydride has been investigated. The aldehydes used were chosen to allow convenient quantitative measurement of binding by ultraviolet spectroscopy. Alkylation of BSA occurred primarily at two highly reactive sites. Va... | Factors affecting cyanoborohydride reduction of aromatic Schiff's bases in proteins. Reductive alkylation of bovine serum albumin (BSA) and wool by a aromatic aldehydes and sodium cyanoborohydride has been investigated. The aldehydes used were chosen to allow convenient quantitative measurement of binding by ultraviole... | [
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PMID:21540 | Electron microscopy of an oligomeric protein stabilized by polyfunctional cross-linking. | Oligomeric proteins can be intramolecularly cross-linked with polylysine in a reaction in which a water soluble carbodiimide mediates an amide linkage between the protein carboxyl groups and the epsilon-amino groups of polylysine. Studies carried out with a cytochrome p-450 indicate that a small number of molecules in ... | Electron microscopy of an oligomeric protein stabilized by polyfunctional cross-linking. Oligomeric proteins can be intramolecularly cross-linked with polylysine in a reaction in which a water soluble carbodiimide mediates an amide linkage between the protein carboxyl groups and the epsilon-amino groups of polylysine. ... | [
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PMID:21546 | Cell transfer studies with the DK/or inbred chicken lines. | The histoincompatibility in the DK-OR-1 (B13B13) and DK/OR-3 (B19B19) inbred White Leghorn chicken lines was assessed with the Simonsen's spleen assay, GVHR mortality counts and antibody production by transferred cells in embryonic in vivo hosts. The two lines appear to be sufficiently histocompatible for use in cell t... | Cell transfer studies with the DK/or inbred chicken lines. The histoincompatibility in the DK-OR-1 (B13B13) and DK/OR-3 (B19B19) inbred White Leghorn chicken lines was assessed with the Simonsen's spleen assay, GVHR mortality counts and antibody production by transferred cells in embryonic in vivo hosts. The two lines ... | [
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PMID:21547 | Role of the major histocompatibility complex in resistance to Marek's disease: restriction of the growth of JMV-MD tumor cells in genetically resistant birds. | B21 is associated with resistance to Marek's disease (MD). Forty populations of chickens from all over the world were examined for the presence of the B21 allele. B21 was found in twelve of these populations and it's presence was confirmed by GVH testing in all ten populations which were tested. The populations in whic... | Role of the major histocompatibility complex in resistance to Marek's disease: restriction of the growth of JMV-MD tumor cells in genetically resistant birds. B21 is associated with resistance to Marek's disease (MD). Forty populations of chickens from all over the world were examined for the presence of the B21 allele... | [
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PMID:21552 | [Development cooperation in the development of a basic medical service]. | Team work in building up a basic medical service. - This article reports on a project of Swiss aid to the developing country of the Peruvian Andes, whose organization is completely integrated into the national Peruvian ministry of health. After having stated the social and medical problems the article explains, how a t... | [Development cooperation in the development of a basic medical service]. Team work in building up a basic medical service. - This article reports on a project of Swiss aid to the developing country of the Peruvian Andes, whose organization is completely integrated into the national Peruvian ministry of health. After ha... | [
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PMID:21553 | [Rural health center in Bali]. | The rural Health Centre of Mengwi, on the island of Bali, was built and equipped for US $ 15,000 by Project Concern, a non-sectarian, medical relief organization. It has been run so successfully by them since it opened in 1974, that not only has the Centre gained the trust of the local community into which it is now fu... | [Rural health center in Bali]. The rural Health Centre of Mengwi, on the island of Bali, was built and equipped for US $ 15,000 by Project Concern, a non-sectarian, medical relief organization. It has been run so successfully by them since it opened in 1974, that not only has the Centre gained the trust of the local co... | [
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PMID:21554 | Development aid through information. Trying a new concept in Columbia. | The origin, execution, and preliminary results of a development project in Cali (Colombia) are presented. This project, which involves a special concept, aims at breaking new ground in the field of development aid. The aim of the Vivamos Mejor foundation, established in Colombia, is to provide practical help for poor f... | Development aid through information. Trying a new concept in Columbia. The origin, execution, and preliminary results of a development project in Cali (Colombia) are presented. This project, which involves a special concept, aims at breaking new ground in the field of development aid. The aim of the Vivamos Mejor found... | [
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PMID:21555 | [Water resources and health problems in developing countries]. | The rapidly increasing use of water for agricultural and hydroelectric development in developing countries is causing serious health problems. These can be divided into two categories; the diseases whose transmission depends on water; and the changes in the life style of the population. We review briefly the principal ... | [Water resources and health problems in developing countries]. The rapidly increasing use of water for agricultural and hydroelectric development in developing countries is causing serious health problems. These can be divided into two categories; the diseases whose transmission depends on water; and the changes in the... | [
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PMID:21556 | [Community health aide. Critical estimation of his task within the nutrition program]. | Community Health Aides (CHA), locally recruited and trained, visit households and identify malnourished children by means of weighing them in monthly intervals, recording the results on "Gomez" weight-for-age charts. The CHA acts as the people's nearest adviser. In order to become a useful if not the most important mem... | [Community health aide. Critical estimation of his task within the nutrition program]. Community Health Aides (CHA), locally recruited and trained, visit households and identify malnourished children by means of weighing them in monthly intervals, recording the results on "Gomez" weight-for-age charts. The CHA acts as ... | [
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PMID:21557 | Smallpox eradication in Rajasthan, India. | In 1962, when the smallpox eradication programme was launched in India, there were 3909 reported cases in Rajasthan. Mass vaccination was introduced but had little impact on the incidence of the disease; in 1970, 4074 cases were reported and in 1971, the reported incidence (4821 cases) was the highest in India. Changes... | Smallpox eradication in Rajasthan, India. In 1962, when the smallpox eradication programme was launched in India, there were 3909 reported cases in Rajasthan. Mass vaccination was introduced but had little impact on the incidence of the disease; in 1970, 4074 cases were reported and in 1971, the reported incidence (482... | [
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PMID:21558 | Malaria in the Republic of the Philippines. A review. | Malaria in the Republic of the Philippines is caused principally by P. falciparum and P. vivax, with the former as predominant species. P. malariae is occasionally reported, while P. ovale is very rare and has been reported only in the island of Palawan. Malaria is widespread in distribution with prevalence varying fro... | Malaria in the Republic of the Philippines. A review. Malaria in the Republic of the Philippines is caused principally by P. falciparum and P. vivax, with the former as predominant species. P. malariae is occasionally reported, while P. ovale is very rare and has been reported only in the island of Palawan. Malaria is ... | [
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PMID:21559 | Microfilarial polyarthritis in a massive Loa loa infestation. A case report. | A Cameroonian affected with massive Loa loa infection developed febrile arthritis with involvement of both knees and the left ankle. Although the patient was first seen by us after one month of treatment with Indomethacin, at this time the joints were still inflamed and microfilariae of Loa loa were found in the synovi... | Microfilarial polyarthritis in a massive Loa loa infestation. A case report. A Cameroonian affected with massive Loa loa infection developed febrile arthritis with involvement of both knees and the left ankle. Although the patient was first seen by us after one month of treatment with Indomethacin, at this time the joi... | [
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PMID:21561 | Ambulatory management in alcoholism. | In the acute phase, management begins with ruling out conditions that would require hospitalization. Moderate withdrawal symptoms in susceptible patients require substitution medication which can be monitored on an outpatient basis. In the subacute phase, after withdrawal, frequent visits, family education and judiciou... | Ambulatory management in alcoholism. In the acute phase, management begins with ruling out conditions that would require hospitalization. Moderate withdrawal symptoms in susceptible patients require substitution medication which can be monitored on an outpatient basis. In the subacute phase, after withdrawal, frequent ... | [
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PMID:21563 | Lower-esophageal sphincter function does not determine resting upper-esophageal sphincter pressure. | Records of 269 esophageal motility studies were reviewed to determine the relationship between lower-esophageal sphincter (LES) function and upper-esophageal sphincter (UES) pressure. Average and greatest UES pressures were similar in patients with LES pressures less than 10 mm Hg or greater than 20 mm Hg, and in pati... | Lower-esophageal sphincter function does not determine resting upper-esophageal sphincter pressure. Records of 269 esophageal motility studies were reviewed to determine the relationship between lower-esophageal sphincter (LES) function and upper-esophageal sphincter (UES) pressure. Average and greatest UES pressures w... | [
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PMID:21564 | Effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics. | By arranging a series of psychological contingencies (unpredictability, uncontrollability, conflict), coupled with delivery of a physical stimulus (electric shock), we produced gastroduodenal mucosal lesions in 7 of 8 rhesus monkeys. The most severe conflict paradigm most consistently produced lesions across subjects. ... | Effect of multiple-stress procedures on monkey gastroduodenal mucosa, serum gastrin, and hydrogen ion kinetics. By arranging a series of psychological contingencies (unpredictability, uncontrollability, conflict), coupled with delivery of a physical stimulus (electric shock), we produced gastroduodenal mucosal lesions ... | [
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PMID:21565 | The natural history of neoplasia. Newer insights into an old problem. | The stages of initiation and promotion in the natural history of epidermal carcinogenesis have been known for many years. Recently, experimental systems other than skin have been shown to exhibit similar, if not completely analogous, stages in the natural history of neoplasia. In particular, the demonstration by Perain... | The natural history of neoplasia. Newer insights into an old problem. The stages of initiation and promotion in the natural history of epidermal carcinogenesis have been known for many years. Recently, experimental systems other than skin have been shown to exhibit similar, if not completely analogous, stages in the na... | [
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PMID:21566 | Kinetic differences between uterine and renal renins in the dog. | It has previously been reported that in the dog the Michaelis constant (Km) of renal renin with respect to homologous plasma substrate is the same as that for the angiotensin-generating enzyme extractable from the myometrium during pregnancy. We have reexamined the kinetics with a different methodology. Enzyme preparat... | Kinetic differences between uterine and renal renins in the dog. It has previously been reported that in the dog the Michaelis constant (Km) of renal renin with respect to homologous plasma substrate is the same as that for the angiotensin-generating enzyme extractable from the myometrium during pregnancy. We have reex... | [
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PMID:21567 | pH-temperature dependence of organic acid transport in rat kidney slices. | Uptake of p-aminohippurate (PAH) by rat kidney slices was optimal at a pH of around 7.3 when incubation temperature was 37 degrees C. At 25 degrees C, however, optimal pH was increased to about 7.5. When the uptake was evaluated as a function of the OH/H ratio of the medium, it was found that optimal uptake is at a con... | pH-temperature dependence of organic acid transport in rat kidney slices. Uptake of p-aminohippurate (PAH) by rat kidney slices was optimal at a pH of around 7.3 when incubation temperature was 37 degrees C. At 25 degrees C, however, optimal pH was increased to about 7.5. When the uptake was evaluated as a function of ... | [
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PMID:21568 | Ionic composition of arterial and mixed venous plasma in the unanesthetized dog. | The use of permanent catheters in the aorta and pulmonary artery permitted the establishment of normal values for hemoglobin concentration in blood and -or pH, PCO2, osmolality, and protein and electrolyte concentrations in the plasma of arterial and venous samples from unanesthetized, undisturbed dogs, and the compari... | Ionic composition of arterial and mixed venous plasma in the unanesthetized dog. The use of permanent catheters in the aorta and pulmonary artery permitted the establishment of normal values for hemoglobin concentration in blood and -or pH, PCO2, osmolality, and protein and electrolyte concentrations in the plasma of a... | [
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PMID:21569 | Mechanism of active chloride transport by urinary bladder of the Colombian toad. | In order to investigate the mechanism of active chloride transport, experiments were performed to verify the previous report that removal of potassium from the solutions bathing the urinary bladders of Colombian toads induced a reversal of short-circuit current (RSCC) and active chloride transport. The present experime... | Mechanism of active chloride transport by urinary bladder of the Colombian toad. In order to investigate the mechanism of active chloride transport, experiments were performed to verify the previous report that removal of potassium from the solutions bathing the urinary bladders of Colombian toads induced a reversal of... | [
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PMID:21570 | The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. | Recent research in the neurobiology of dreaming sleep provides new evidence for possible structural and functional substrates of formal aspects of the dream process. The data suggest that dreaming sleep is physiologically determined and shaped by a brain stem neuronal mechanism that can be modeled physiologically and m... | The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. Recent research in the neurobiology of dreaming sleep provides new evidence for possible structural and functional substrates of formal aspects of the dream process. The data suggest that dreaming sleep is physiologically det... | [
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PMID:21571 | An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels. | Sulpiride is a new and chemically different neuroleptic. In a study of 16 severely ill schizophrenic patients, this compound displayed definite evidence of antipsychotic activity while producing few adverse reactions. The relative absence of extrapyramidal side effects may indicate that sulpride has a low potential for... | An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels. Sulpiride is a new and chemically different neuroleptic. In a study of 16 severely ill schizophrenic patients, this compound displayed definite evidence of antipsychotic activity while producing few adver... | [
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PMID:21572 | [Long-term study on the influence of running exercise, food restriction, running exercise + food restriction and of parenterally applicated testis cells on age-parameters of the rat (author's transl)]. | Preliminary results of a long-term study on 1100 male Sprague-Dawley rats are presented, showing the influence of running exercise, of restricted diet, of both of these together and of the s.c. application of lypholized testis cells. Up to now animals aged 9, 15 and 24 mths were investigated. The test-animals were expo... | [Long-term study on the influence of running exercise, food restriction, running exercise + food restriction and of parenterally applicated testis cells on age-parameters of the rat (author's transl)]. Preliminary results of a long-term study on 1100 male Sprague-Dawley rats are presented, showing the influence of runn... | [
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PMID:21573 | Effect of aminoglutethimide on calcitonin sensitivity. | Studying the influence of aminoglutethimide treatment on calcitonin sensitivity, serum calcium levels were measured in normal rats, aminoglutethimide treated rats, adrenalectomized and castrated rats, following i.v. injection of porcine calcitonin. The aminoglutethimide administration caused a more distinct calcitonin ... | Effect of aminoglutethimide on calcitonin sensitivity. Studying the influence of aminoglutethimide treatment on calcitonin sensitivity, serum calcium levels were measured in normal rats, aminoglutethimide treated rats, adrenalectomized and castrated rats, following i.v. injection of porcine calcitonin. The aminogluteth... | [
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PMID:21574 | [General directions for the care of the dying patient by the Swiss Academy of Medical Sciences (author's transl)]. | The medical ethical and legal principles for the care of the dying are given, different for the patient with judgement and for the inconscieous patient. Contrary to the patient in danger of death (Moriturus) where the doctor has the duty to save the live, in the case of the dying (Moribundus), where the disease is irre... | [General directions for the care of the dying patient by the Swiss Academy of Medical Sciences (author's transl)]. The medical ethical and legal principles for the care of the dying are given, different for the patient with judgement and for the inconscieous patient. Contrary to the patient in danger of death (Morituru... | [
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PMID:21575 | [Somatical performance and environment in the elderly (author's transl)]. | The arrangement with the envirement requires somatical performance of men. We developed a mathematical model by recording data of performance. This model shows a decreasing capacity of performance correlated with age. The real meassured data are vastly different to theoretical conception. In difference to the assumptio... | [Somatical performance and environment in the elderly (author's transl)]. The arrangement with the envirement requires somatical performance of men. We developed a mathematical model by recording data of performance. This model shows a decreasing capacity of performance correlated with age. The real meassured data are ... | [
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PMID:21576 | Thermal contraction-relaxation and dissolution of rat tail tendon collagen in different ages. | Here thermal contraction-relaxation and dissolution of collagen from rat tail tendon fibers were studied simultaneously. It is concluded that both processes change their character in the same manner with increasing age and that the relaxation phase probably is a result of the dissolution of collagen from the fibers. | Thermal contraction-relaxation and dissolution of rat tail tendon collagen in different ages. Here thermal contraction-relaxation and dissolution of collagen from rat tail tendon fibers were studied simultaneously. It is concluded that both processes change their character in the same manner with increasing age and tha... | [
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PMID:21577 | [Acute confusional states in the elderly (author's transl)]. | It is described that the acute confusional state in elderly people can be regarded as the combination of a catastrophe-reaction, superimposed on the primary symptoms of an underlying physical disorder. The catastrophe-reaction, the secondary symptoms, are described as the manifestation of the failure of the hypothalamo... | [Acute confusional states in the elderly (author's transl)]. It is described that the acute confusional state in elderly people can be regarded as the combination of a catastrophe-reaction, superimposed on the primary symptoms of an underlying physical disorder. The catastrophe-reaction, the secondary symptoms, are des... | [
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PMID:21596 | Estimation of plasma lorazepam by gas-liquid chromatography and a benzene extraction. | Plasma lorazepam can be easily and reliably estimated using a simple single stage benzene extraction and gas-lizuid chromatography with flunitrazepam as the internal standard. Reproducible results within the clinical range of plasma levels were obtained. This method permits the extraction and chromatographing of 40 sam... | Estimation of plasma lorazepam by gas-liquid chromatography and a benzene extraction. Plasma lorazepam can be easily and reliably estimated using a simple single stage benzene extraction and gas-lizuid chromatography with flunitrazepam as the internal standard. Reproducible results within the clinical range of plasma l... | [
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PMID:21603 | Determinants of lung bacterial clearance in mice after acute hypoxia. | Net lung bacterial clearance in normal mice is determined by the balance of in vivo bacterial multiplication on the one hand, and the defense mechanisms of mucociliary clearance and phagocytosis and killing by the oxygen-dependent alveolar macrophage on the other. The bactericidal function of the macrophage is the majo... | Determinants of lung bacterial clearance in mice after acute hypoxia. Net lung bacterial clearance in normal mice is determined by the balance of in vivo bacterial multiplication on the one hand, and the defense mechanisms of mucociliary clearance and phagocytosis and killing by the oxygen-dependent alveolar macrophage... | [
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PMID:21604 | Detection of penumococcal antigens in the sputum in pneumococcal pneumonia. | Forty-seven patients with bacterial pneumonia were grouped by use of clinical criteria according to the relative certainty of a diagnosis of pneumococcal pneumonia. Sputums were tested for pneumococcal antigens by counterimmunoelectrophoresis with polyvalent pneumococcal antiserum. Antigens were detected in the sputum ... | Detection of penumococcal antigens in the sputum in pneumococcal pneumonia. Forty-seven patients with bacterial pneumonia were grouped by use of clinical criteria according to the relative certainty of a diagnosis of pneumococcal pneumonia. Sputums were tested for pneumococcal antigens by counterimmunoelectrophoresis w... | [
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PMID:21606 | Regional quality control survey of blood-gas analysis. | We undertook an external quality control survey of blood-gas analysis in 16 laboratories at 13 hospitals. All samples were prepared in the laboratories under investigation by equilibration of blood or serum with gas mixtures of known composition. pH of serum was measured with no significant bias but with an SD of rando... | Regional quality control survey of blood-gas analysis. We undertook an external quality control survey of blood-gas analysis in 16 laboratories at 13 hospitals. All samples were prepared in the laboratories under investigation by equilibration of blood or serum with gas mixtures of known composition. pH of serum was me... | [
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PMID:21607 | A long-term evaluation of the CentrifiChem centrifugal microanalyser during routine use in the clinical biochemistry laboratory. | The CentrifiChem centrifugal microanalyser (model 300) has been used routinely in this laboratory for two years. Its reliability for performing total bilirubin, aspartate aminotransferase alkaline phosphatase and gamma-glutamyl transferase analyses during this time is reported, using methods modified in a preliminary s... | A long-term evaluation of the CentrifiChem centrifugal microanalyser during routine use in the clinical biochemistry laboratory. The CentrifiChem centrifugal microanalyser (model 300) has been used routinely in this laboratory for two years. Its reliability for performing total bilirubin, aspartate aminotransferase alk... | [
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PMID:21608 | The genetic and biochemical properties of the D-amino acid oxidases in human tissues. | 1. Two distinct forms of oxidases catalysing the oxidative deamidation of D-alpha-amino acids have been identified in human tissues: D-amino acid oxidase (DAMOX) and D-aspartate oxidase (DASOX). 2. The enzymes differ in their electrophoretic properties, tissue distribution, binding with flavine adenine denucleotide, he... | The genetic and biochemical properties of the D-amino acid oxidases in human tissues. 1. Two distinct forms of oxidases catalysing the oxidative deamidation of D-alpha-amino acids have been identified in human tissues: D-amino acid oxidase (DAMOX) and D-aspartate oxidase (DASOX). 2. The enzymes differ in their electrop... | [
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PMID:21605 | [Anhidrotic activity of anticholinergics in mice. Influence of mode of administration]. | Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities according to the mode of administration of the different anticholinergics showed definite differ... | [Anhidrotic activity of anticholinergics in mice. Influence of mode of administration]. Anhidrotic concentrations 50 of four anticholinergics were determined in mice using an original skin palmar conductance method. Intra-peritoneal, intra-palmar and topical routes were compared. Relative anhidrotic activities accordin... | [
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PMID:21610 | Hepatotoxicity of erythromycin estolate during pregnancy. | Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo for 6 weeks. Levels of serum glutamic oxalacetic transamin... | Hepatotoxicity of erythromycin estolate during pregnancy. Women in the second half of pregnancy, who were infected with genital mycoplasmas and who gave written informed consent, were randomly assigned to receive capsules of identical appearance containing erythromycin estolate, clindamycin hydrochloride, or a placebo ... | [
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PMID:21611 | Mutation of an inosine-producing strain of Bacillus subtilis to DL-methionine sulfoxide resistance for guanosine production. | An inosine-producing strain of Bacillus subtilis was mutated to resistance against the antagonist of glutamine, DL-methionine sulfoxide. Among the mutants derived, guanosine producers were observed frequently. The best strain, 14119, produced 9.6 g of guanosine per liter at a weight yield of 12% from consumed sugar. In... | Mutation of an inosine-producing strain of Bacillus subtilis to DL-methionine sulfoxide resistance for guanosine production. An inosine-producing strain of Bacillus subtilis was mutated to resistance against the antagonist of glutamine, DL-methionine sulfoxide. Among the mutants derived, guanosine producers were observ... | [
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PMID:21612 | Production, purification, and characterization of alpha-amylase from Thermomonospora curvata. | Thermomonospora curvata produces an extracellular alpha-amylase. Maximal amylase production by cultures in a starch-mineral salts medium occurred at pH 7.5 and 53 degrees C. The crude enzyme was unstable to heating (65 degrees C) at pH 4 to 6, and was activated when heated at pH 8. The enzyme was purified 66-fold with ... | Production, purification, and characterization of alpha-amylase from Thermomonospora curvata. Thermomonospora curvata produces an extracellular alpha-amylase. Maximal amylase production by cultures in a starch-mineral salts medium occurred at pH 7.5 and 53 degrees C. The crude enzyme was unstable to heating (65 degrees... | [
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PMID:21613 | Bacterial lipopolysaccharides as inducers of disease resistance in tobacco. | The cell wall component of Pseudomonas solanacearum that induces disease resistance in tobacco was highly heat stable at neutral or alkaline pH but highly labile at acid pH. Activity was unaffected by nucleases and proteases but destroyed by a mixture of beta-glycosidases. Washing of bacterial cell walls released a lip... | Bacterial lipopolysaccharides as inducers of disease resistance in tobacco. The cell wall component of Pseudomonas solanacearum that induces disease resistance in tobacco was highly heat stable at neutral or alkaline pH but highly labile at acid pH. Activity was unaffected by nucleases and proteases but destroyed by a ... | [
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PMID:21634 | Effect of blood transfusion in low birthweight infants. | 143 fresh blood transfusions were given to 32 low birthweight babies, 28 of whom had hyaline membrane disease. The arterial or central venous pressure was raised by a blood transfusion if before transfusion the mean arterial pressure was less than 35 mmHg or if the diastolic central venous pressure was less than -- 0-5... | Effect of blood transfusion in low birthweight infants. 143 fresh blood transfusions were given to 32 low birthweight babies, 28 of whom had hyaline membrane disease. The arterial or central venous pressure was raised by a blood transfusion if before transfusion the mean arterial pressure was less than 35 mmHg or if th... | [
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PMID:21637 | Effect of glucocorticoids on the hexose monophosphate pathway in human rheumatoid synovial lining cells in vitro and in vivo. | Human rheumatoid synovial lining cells have up to four times the capacity to oxidize glucose 6-phosphate, the first step of the hexose monophosphate pathway, as do the nonrheumatoid cells. The reducing equivalents produced by this system have many significant metabolic effects. Exposure of these cells by 10(-5) M predn... | Effect of glucocorticoids on the hexose monophosphate pathway in human rheumatoid synovial lining cells in vitro and in vivo. Human rheumatoid synovial lining cells have up to four times the capacity to oxidize glucose 6-phosphate, the first step of the hexose monophosphate pathway, as do the nonrheumatoid cells. The r... | [
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PMID:21638 | Release of antral and duodenal gastrin in response to an intestinal meal. | In dogs prepared with isolated, innervated antral pouches, intraduodenal perfusion with liver extract at pH 7, with the atrum buffered at pH 7, resulted in a significant release of gastrin selectively from the antrum and from the duodenum. Acidification of the meal to pH 1 abolished both antral and duodenal gastrin rel... | Release of antral and duodenal gastrin in response to an intestinal meal. In dogs prepared with isolated, innervated antral pouches, intraduodenal perfusion with liver extract at pH 7, with the atrum buffered at pH 7, resulted in a significant release of gastrin selectively from the antrum and from the duodenum. Acidif... | [
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PMID:21639 | Hydroxylation of 5,5-diphenylhydantoin (phenytoin) by dog liver microsomes. | Chang and Glazko in 1972 had reported failure to demonstrate any production from 5-5-diphenylhydantoin (phenytoin, DPH) by dog liver microsomes of either 5-(m-hydroxyphenyl-5-phenylhydantoin (m-HPPH) or 5-(P-hydroxyphenyl-5-phenylhydantoin (p-HPPH), metabolites of DPH produced by the dog in vivo. We have incubated DPH... | Hydroxylation of 5,5-diphenylhydantoin (phenytoin) by dog liver microsomes. Chang and Glazko in 1972 had reported failure to demonstrate any production from 5-5-diphenylhydantoin (phenytoin, DPH) by dog liver microsomes of either 5-(m-hydroxyphenyl-5-phenylhydantoin (m-HPPH) or 5-(P-hydroxyphenyl-5-phenylhydantoin (p-H... | [
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PMID:21641 | [pH and lactic acid values in the cerebrospinal fluid as a diagnostic aid for differentiating viral and purulent meningoencephalitis]. | Concentrations of lactate and pH were determined in the CSF of 20 normal children, 36 with viral meningitis, 16 with purulent meningitis and six with tuberculous meningitis. No differences were found between normal cases and those with viral meningitis. In patients with purulent meningitis concentration of lactate was ... | [pH and lactic acid values in the cerebrospinal fluid as a diagnostic aid for differentiating viral and purulent meningoencephalitis]. Concentrations of lactate and pH were determined in the CSF of 20 normal children, 36 with viral meningitis, 16 with purulent meningitis and six with tuberculous meningitis. No differen... | [
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PMID:21642 | [Acid-base status in the blood of domestic pigs during exhausting locomotor stress of small and medium intensity]. | Twenty-two fattening pigs were stressed until their rectal temperatures had reached 42 degrees C. The means of stress included walking on moving conveyor belt at ambient temperatures between 22 degrees C and 27 degrees C and relative humidities between 69 and 98%, belt speeds of 0.7 m/s, 1.3 m/s or 0.7 m/s, and stimula... | [Acid-base status in the blood of domestic pigs during exhausting locomotor stress of small and medium intensity]. Twenty-two fattening pigs were stressed until their rectal temperatures had reached 42 degrees C. The means of stress included walking on moving conveyor belt at ambient temperatures between 22 degrees C a... | [
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PMID:21644 | Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene. | Psychotic women with schizophrenic symptoms were treated with melperone 100 mg X 3 (n = 29) or thiothixene 10 mg X 3 (N = 34) USING A DOUBLE-BLIND PROCEDURE. Before and during treatment, levels of HVA, MOPEG, and 5-HIAA, the major metabolites of DA, NE, and 5-HT, were determined in lumbar cerebrospinal fluid by a mass ... | Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene. Psychotic women with schizophrenic symptoms were treated with melperone 100 mg X 3 (n = 29) or thiothixene 10 mg X 3 (N = 34) USING A DOUBLE-BLIND PROCEDURE. Before and during treatment, levels of HVA, MOPEG, an... | [
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PMID:21645 | Adult cryptorchids: Sexual development and activity. | Plasma testosterone in 72 unilateral and 83 bilateral cryptorchids, 11-45 years of age, revealed that, from 13 years on , values of male hormone were lower than in the control group of 69 normal boys and 85 fertile and potent men. Analysis of heterosexual development by means of the HTDM questionnaire in 49 unilateral ... | Adult cryptorchids: Sexual development and activity. Plasma testosterone in 72 unilateral and 83 bilateral cryptorchids, 11-45 years of age, revealed that, from 13 years on , values of male hormone were lower than in the control group of 69 normal boys and 85 fertile and potent men. Analysis of heterosexual development... | [
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PMID:21646 | [Ultrastructure of B-cell tumors of the pancreas (insulinomas - insular carcinoid tumors)]. | The subcellular organization of 6 B-cell tumours of the human pancreas was studied. The tumour parenchyma consisted of processed light, dark, and moderately electron dense cells containing insulin granules. The presence of villi in the cytoplasm of tumour cells and intranuclear fibrills was demonstrated. The participat... | [Ultrastructure of B-cell tumors of the pancreas (insulinomas - insular carcinoid tumors)]. The subcellular organization of 6 B-cell tumours of the human pancreas was studied. The tumour parenchyma consisted of processed light, dark, and moderately electron dense cells containing insulin granules. The presence of villi... | [
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PMID:21648 | Polyarteritis nodosa and deafness. A human temporal bone study. | Temporal bone changes were described in a 66 year old woman with polyarteritis nodosa who became deaf 7 months before death. Polyarteritis nodosa of the left internal auditory artery was demonstrated with fibrosis and bone formation involving the cochlea and vestibular system. Endolymphatic hydrops of the basal turn of... | Polyarteritis nodosa and deafness. A human temporal bone study. Temporal bone changes were described in a 66 year old woman with polyarteritis nodosa who became deaf 7 months before death. Polyarteritis nodosa of the left internal auditory artery was demonstrated with fibrosis and bone formation involving the cochlea a... | [
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PMID:21652 | Biochemical and genetic factors in the heat inactivation of murine beta-glucuronidase. | The enzymes coded for by two alleles at the glucuronidase structural locus (Gus) were compared in their response to pH, buffering anion, buffer molarity, ionic strength, and temperature. The heat-labile Gush gene product responded in a qualitatively similar but quantitatively reduced manner compared to the relatively h... | Biochemical and genetic factors in the heat inactivation of murine beta-glucuronidase. The enzymes coded for by two alleles at the glucuronidase structural locus (Gus) were compared in their response to pH, buffering anion, buffer molarity, ionic strength, and temperature. The heat-labile Gush gene product responded in... | [
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PMID:21653 | Studies on the female sterile mutant rudimentary of Drosophila melanogaster. II. An analysis of aspartate transcarbamylase and dihydroorotase activities in wild-type and rudimentary strains. | The activities of the enzymes aspartate transcarbamylase (ATCase) and dihydroorotase (DHOase) were determined in adult females from a wild-type strain and from eight different alleles of the X-linked mutation rudimentary (r) of Drosophila melanogaster. The alleles chosen span the genetic map of the r locus. The charact... | Studies on the female sterile mutant rudimentary of Drosophila melanogaster. II. An analysis of aspartate transcarbamylase and dihydroorotase activities in wild-type and rudimentary strains. The activities of the enzymes aspartate transcarbamylase (ATCase) and dihydroorotase (DHOase) were determined in adult females fr... | [
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PMID:21654 | Properties of soluble somatostatin-binding protein. | A soluble somatostatin-binding protein was detected in the cytosol fractions of various rat, human and bovine tissues. Maximum binding occurred at pH8.0-8.5 and was Ca(2+)-dependent. The specific binding of somatostatin per 10mug of cytosol protein from 12 rat tissues ranged between 36 and 15%, and 3% for peripheral bl... | Properties of soluble somatostatin-binding protein. A soluble somatostatin-binding protein was detected in the cytosol fractions of various rat, human and bovine tissues. Maximum binding occurred at pH8.0-8.5 and was Ca(2+)-dependent. The specific binding of somatostatin per 10mug of cytosol protein from 12 rat tissues... | [
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PMID:21655 | Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (Rhodochrous group) N.C.I.B. 11216. | 1. An organism utilizing benzonitrile as sole carbon and nitrogen source was isolated by the enrichment-culture technique and identified as a Nocardia sp. of the rhodochrous group. 2. Respiration studies indicate that nitrile degradation proceeds through benzoic acid and catechol. 3. Cell-free extracts of benzonitrile-... | Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (Rhodochrous group) N.C.I.B. 11216. 1. An organism utilizing benzonitrile as sole carbon and nitrogen source was isolated by the enrichment-culture technique and identified as a Nocardia sp. of the rhodochrous group. 2. Respiration st... | [
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PMID:21656 | Kinetic properties of a magnesium ion- and calcium ion-stimulated adenosine triphosphatase from the outer-membrane fraction of rat spleen mitochondria. | 1. Isolated outer membranes from rat spleen mitochondria can be stored in liquid N(2) for several weeks without significant loss of ATPase (adenosine triphosphatase) activity. 2. The ATPase reaction has a broad pH optimum centering on neutral pH, with little significant activity above pH9.0 or below pH5.5. 3. A sigmoid... | Kinetic properties of a magnesium ion- and calcium ion-stimulated adenosine triphosphatase from the outer-membrane fraction of rat spleen mitochondria. 1. Isolated outer membranes from rat spleen mitochondria can be stored in liquid N(2) for several weeks without significant loss of ATPase (adenosine triphosphatase) ac... | [
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PMID:21657 | Evidence for two-step binding of reduced nicotinamide-adenine dinucleotide to aldehyde dehydrogenase. | The displacement of NADH from cytoplasmic aldehyde dehydrogenase (EC 1.2.1.3) from sheep liver was studied by using NAD+, 1,10-phenanthroline, ADP-ribose, deamino-NAD+ and pyridine-3-aldehyde-adenine dinucleotide as displacing agents, by following the decrease in fluorescence as a function of time. The data obtained co... | Evidence for two-step binding of reduced nicotinamide-adenine dinucleotide to aldehyde dehydrogenase. The displacement of NADH from cytoplasmic aldehyde dehydrogenase (EC 1.2.1.3) from sheep liver was studied by using NAD+, 1,10-phenanthroline, ADP-ribose, deamino-NAD+ and pyridine-3-aldehyde-adenine dinucleotide as di... | [
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PMID:21658 | Purification and some properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase from human liver. | Human liver 1-aspartamido-beta-N-acetylglucosamine amidohydrolase (aspartylglucosylaminase, EC 3.5.1.26) was purified 17 500-fold to apparent homogeneity as judged from polyacrylamide-gel disc electrophoresis. A pH optimum of 7.7-9.0 was found. The Km value was pH- and temperature-dependent. At 37 degrees C and pH 7.7,... | Purification and some properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase from human liver. Human liver 1-aspartamido-beta-N-acetylglucosamine amidohydrolase (aspartylglucosylaminase, EC 3.5.1.26) was purified 17 500-fold to apparent homogeneity as judged from polyacrylamide-gel disc electrophoresis. A ... | [
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PMID:21659 | Effect of substrates and effectors on the reversible inactivation of pig spleen phosphofructokinase by adenosine triphosphate. | 1. To investigate the mechanism of the reversible inactivation of pig spleen phosphofructokinase by ATP, the effect of order of addition of reactants (substrates, effectors and enzyme solution) was studied by preincubating the enzyme before assay with various combinations of its substrates and effectors. 2. Preincubati... | Effect of substrates and effectors on the reversible inactivation of pig spleen phosphofructokinase by adenosine triphosphate. 1. To investigate the mechanism of the reversible inactivation of pig spleen phosphofructokinase by ATP, the effect of order of addition of reactants (substrates, effectors and enzyme solution)... | [
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PMID:21667 | [Synthesis and physico-chemical properties of the antihypertensive agent urapidil (author's transl)]. | 6-(3-[4-(o-Methoxyphenyl)-1-piperazinyl]-propylamino)-1,3-dimethyluracil (Urapidil, Ebrantil) is a new antihypertensive agent whose synthesis and physico-chemical properties are described. The size of the permeation constant KD of the passive transport through collodion-lecithin membranes and the value of the partition... | [Synthesis and physico-chemical properties of the antihypertensive agent urapidil (author's transl)]. 6-(3-[4-(o-Methoxyphenyl)-1-piperazinyl]-propylamino)-1,3-dimethyluracil (Urapidil, Ebrantil) is a new antihypertensive agent whose synthesis and physico-chemical properties are described. The size of the permeation co... | [
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PMID:21668 | Effect of dihydroergotoxine on activities of beta-receptor stimulators. | The effect of dihydroergotoxine (DET), an alpha-receptor blocker, on the bronchodilating effect of various beta-receptor stimulators was examined using the isolated guinea-pig tracheal smooth muscle. Relaxation of isolated guinea-pig tracheal smooth muscle with isoproterenol hydrochloride, salbutamol hemisulfate and cl... | Effect of dihydroergotoxine on activities of beta-receptor stimulators. The effect of dihydroergotoxine (DET), an alpha-receptor blocker, on the bronchodilating effect of various beta-receptor stimulators was examined using the isolated guinea-pig tracheal smooth muscle. Relaxation of isolated guinea-pig tracheal smoot... | [
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PMID:21669 | A study of antidepressant activity of some indole alkylamines. | The antidepressant characteristics of three indole alkylamines were investigated and compared with phenelzine and imipramine by utilising specific pharmacological tools like reserpine, amphetamine, tryptamine and tetrabenazine for determining their possible mechanism of action. Amongst the three indole compounds invest... | A study of antidepressant activity of some indole alkylamines. The antidepressant characteristics of three indole alkylamines were investigated and compared with phenelzine and imipramine by utilising specific pharmacological tools like reserpine, amphetamine, tryptamine and tetrabenazine for determining their possible... | [
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PMID:21671 | Bioavailability of quinidine in slow-release form. A comparison between two preparations containing quinidine bisulphate as the active constituent. | Two different slow-release preparations of quinidine bisulphate (A and B) have been tested. The in vitro dissolution rate of preparation B was substantially lower in intestinal than in gastric juice, whereas the release rate of quinidine from preparation A was virtually unaffected by the pH of the dissolution medium. A... | Bioavailability of quinidine in slow-release form. A comparison between two preparations containing quinidine bisulphate as the active constituent. Two different slow-release preparations of quinidine bisulphate (A and B) have been tested. The in vitro dissolution rate of preparation B was substantially lower in intest... | [
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PMID:21677 | Flunitrazepam compared with althesin as an induction agent in balanced anaesthesia. | The effects of flunitrazepam and Althesin as anaesthetic induction agents were studied in a double-blind trial in 97 patients undergoing abdominal or gynaecological surgery. There was no difference between the two preparations in respect of the quality of induction. A marked difference in the quality of maintenance of ... | Flunitrazepam compared with althesin as an induction agent in balanced anaesthesia. The effects of flunitrazepam and Althesin as anaesthetic induction agents were studied in a double-blind trial in 97 patients undergoing abdominal or gynaecological surgery. There was no difference between the two preparations in respec... | [
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PMID:21678 | Studies of drugs given before anaesthesia XXVI: lorazepam. | Lorazepam has been studied as preanaesthetic medication given by mouth, i.m. and i.v. Sediation and side-effects and the incidence of anterograde amnesia in patients having a standard operation under methohexitone-nitrous oxide-oxygen anaesthesia were assessed. In a preliminary study of three i.m. (2-, 4- and 8-mg) and... | Studies of drugs given before anaesthesia XXVI: lorazepam. Lorazepam has been studied as preanaesthetic medication given by mouth, i.m. and i.v. Sediation and side-effects and the incidence of anterograde amnesia in patients having a standard operation under methohexitone-nitrous oxide-oxygen anaesthesia were assessed.... | [
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PMID:21679 | Substrate and substrate analogue binding properties of Renilla luciferase. | Luciferase from the anthozoan coelenterate Renilla reniformis catalyzes the oxidative decarboxylation of luciferin consuming 1 mol of O2 per mol of luciferin oxidized and producing 1 mol of CO2, 1 mol of oxyluciferin, and light (lambdaB, 480 nm) with a 5.5% quantum yield. In this work we have examined the binding chara... | Substrate and substrate analogue binding properties of Renilla luciferase. Luciferase from the anthozoan coelenterate Renilla reniformis catalyzes the oxidative decarboxylation of luciferin consuming 1 mol of O2 per mol of luciferin oxidized and producing 1 mol of CO2, 1 mol of oxyluciferin, and light (lambdaB, 480 nm)... | [
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PMID:21680 | Pyridoxamine-pyruvate transaminase. 1. Determination of the active site stoichiometry and the pH dependence of the dissociation constant for 5'-deoxypyridoxal. | Spectrophotometric titration of pyridoxamine-pyruvate transaminase (EC 2.6.1.30) with pyridoxal at pH 7.15 gives four equivalent binding sites per tetramer. The pH dependence of the equilibrium constant for the association of 5'-deoxypyridoxal with the active site lysine residue was determined spectrophotometrically. T... | Pyridoxamine-pyruvate transaminase. 1. Determination of the active site stoichiometry and the pH dependence of the dissociation constant for 5'-deoxypyridoxal. Spectrophotometric titration of pyridoxamine-pyruvate transaminase (EC 2.6.1.30) with pyridoxal at pH 7.15 gives four equivalent binding sites per tetramer. The... | [
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0.049818672239780426,
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0.05516693741083145,
0.06... |
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