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PMID:21683 | Isoelectric focus analysis of rat anti-phosphocholine antibodies. | Anti-phosphocholine (PC) antibodies in sera from four strains of rats were examined before and afterimmunization with either Streptococcus pneumoniae R36A, which contains PC as a cell wall component, or with PC-coupled keyhole limpet hemocyanin (PC-KLH). PC-specific protein was purified from pooled immune sera and show... | Isoelectric focus analysis of rat anti-phosphocholine antibodies. Anti-phosphocholine (PC) antibodies in sera from four strains of rats were examined before and afterimmunization with either Streptococcus pneumoniae R36A, which contains PC as a cell wall component, or with PC-coupled keyhole limpet hemocyanin (PC-KLH).... | [
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PMID:21684 | Interaction of oligoribocytidylates with T7 DNA in neutral and acid media. | Oligoribocytidylates of chain length 4 to 12 were found to interact with native T7 DNA at neutral and slightly acid pH. The results suggest that binding occurred at deoxycytosine clusters which may be displaced by the oligomers at neutral pH, while a local triple-stranded structure would be formed at acid pH. Transcrip... | Interaction of oligoribocytidylates with T7 DNA in neutral and acid media. Oligoribocytidylates of chain length 4 to 12 were found to interact with native T7 DNA at neutral and slightly acid pH. The results suggest that binding occurred at deoxycytosine clusters which may be displaced by the oligomers at neutral pH, wh... | [
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PMID:21685 | Rabbit liver transglutaminase: physical, chemical, and catalytic properties. | Transglutaminase (R-glutaminyl-peptide:amine alpha-glutamyl-yltransferase [EC 2.3.2.13]) has been purified to apparent homogeneity from extracts of rabbit liver. The enzyme is a single polypeptide chain of approximately 80 000 molecular weight containing one catalytic site per molecule. That the isolated enzyme is the ... | Rabbit liver transglutaminase: physical, chemical, and catalytic properties. Transglutaminase (R-glutaminyl-peptide:amine alpha-glutamyl-yltransferase [EC 2.3.2.13]) has been purified to apparent homogeneity from extracts of rabbit liver. The enzyme is a single polypeptide chain of approximately 80 000 molecular weight... | [
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PMID:21687 | Classification and localization of hemoglobin binding sites on the red blood cell membrane. | The binding of hemoglobin to the red cell membrane was characterized over a wide range of free hemoglobin concentrations by measurement of membrane bound and supernatant hemoglobin. Scatchard analysis of the binding data revealed two classes of sites: high affinity sites with a binding constant of 1 X 10(8) M-1 and 1.2... | Classification and localization of hemoglobin binding sites on the red blood cell membrane. The binding of hemoglobin to the red cell membrane was characterized over a wide range of free hemoglobin concentrations by measurement of membrane bound and supernatant hemoglobin. Scatchard analysis of the binding data reveale... | [
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PMID:21689 | A change in the internal affinity of LK goat red-cell sodium pumps induced by high pH. | The K inhibition of ouabain-sensitive ATPase activity of LK goat red cell membranes is greatly reduced at high pH. This effect is reversible, and specific, since the apparent affinities for ATP, ouabain or external K do not alter. Anti-L-treated membranes show a similar alkali-induced affinity change, but have a lower ... | A change in the internal affinity of LK goat red-cell sodium pumps induced by high pH. The K inhibition of ouabain-sensitive ATPase activity of LK goat red cell membranes is greatly reduced at high pH. This effect is reversible, and specific, since the apparent affinities for ATP, ouabain or external K do not alter. An... | [
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PMID:21690 | Counter-transport mediated by the lactose permease of Escherichia coli. | When the two main energy yielding pathways, respiration and the membrane ATPase of Escherichia coli are poisoned, the lactose permease is unable to accomplish accumulative transport of thiogalactosides, but the efflux of preloaded substrate can be coupled to a transiently uphill transport of exogenous substrate. This t... | Counter-transport mediated by the lactose permease of Escherichia coli. When the two main energy yielding pathways, respiration and the membrane ATPase of Escherichia coli are poisoned, the lactose permease is unable to accomplish accumulative transport of thiogalactosides, but the efflux of preloaded substrate can be ... | [
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PMID:21691 | Fractionation of membrane vesicles. II. A method for separation of membrane vesicles bearing different enzymes by free-flow electrophoresis. | Free-flow electrophoresis was used to subfractionate membrane vesicles from calf thymocyte plasma membranes. The fractionation resulted in a separation of vesicle populations bearing four different enzymes: alkaline nitrophenyl-phosphatase (orthophosphoric-monoester phosphohydrolase (alkalin optimum) EC 3.1.3.1), gamma... | Fractionation of membrane vesicles. II. A method for separation of membrane vesicles bearing different enzymes by free-flow electrophoresis. Free-flow electrophoresis was used to subfractionate membrane vesicles from calf thymocyte plasma membranes. The fractionation resulted in a separation of vesicle populations bear... | [
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PMID:21692 | Permeability of amino acids into liposomes. | 1. A simple and rapid assay for the measurement of permeability of amino acids into liposome membrane was carried out by using the liposomes trapping D-amino acid oxidase (D-amino acid: O2 oxidoreductase (deaminating), EC 1.4.3.3) inside the membrane. 2. Permeability of amino acids into liposomes depended on the lipid ... | Permeability of amino acids into liposomes. 1. A simple and rapid assay for the measurement of permeability of amino acids into liposome membrane was carried out by using the liposomes trapping D-amino acid oxidase (D-amino acid: O2 oxidoreductase (deaminating), EC 1.4.3.3) inside the membrane. 2. Permeability of amino... | [
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PMID:21694 | Effects of pH on the properties of normal and 5-fluorouracil-containing tRNAs. | Transfer RNAs isolated from Escherichia coli B grown in the presence of 5-fluorouracil (FIUra) show variations in their aminoacylation levels when compared with normal samples. Some of these variations result from the more stringent aminoacylation reaction conditions required for FIUra-tRNAs. Increasing the reaction pH... | Effects of pH on the properties of normal and 5-fluorouracil-containing tRNAs. Transfer RNAs isolated from Escherichia coli B grown in the presence of 5-fluorouracil (FIUra) show variations in their aminoacylation levels when compared with normal samples. Some of these variations result from the more stringent aminoacy... | [
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PMID:21695 | Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue. | D(+)-Lysopine dehydrogenase of an octopine-type Crown Gall tumour has been partially purified and a number of kinetic parameters have been determined. D(+)-Lysopine dehydrogenase catalyzes the reductive condensation of pyruvate and one of at least six different L-amino acids, as well as the reverse reactions, with pref... | Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue. D(+)-Lysopine dehydrogenase of an octopine-type Crown Gall tumour has been partially purified and a number of kinetic parameters have been determined. D(+)-Lysopine dehydrogenase catalyzes the reductive condensation of pyruvate and one of at least... | [
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PMID:21696 | Coordinate and non-coordinate accululation of aspartate transcarbamylase and dihydroorotase in synchronous Chlorella cells growing on different nitrogen sources. | Regulation of the levels of aspartate transcarbamylase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2) and dihydroorotase (L-5,6-dihydro-orotate amidohydrolase, EC 3.5.2.3) was studied in synchronous cultures of the eucaryotic microorganism Chlorella. Analytical polyacrylamide gel electrophoresis and ... | Coordinate and non-coordinate accululation of aspartate transcarbamylase and dihydroorotase in synchronous Chlorella cells growing on different nitrogen sources. Regulation of the levels of aspartate transcarbamylase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2) and dihydroorotase (L-5,6-dihydro-oro... | [
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PMID:21697 | Characterization of the aspartate carbamoyltransferase fragment generated by protease action on the pyrimidine-3 gene product of Neurospora crassa. | The molecular weight of the fragment of aspartate carbamoyltransferase (carbamoylphosphate: L-aspartate carbamoyltransferase, EC 2.1.3.2) of Neurospora crassa following proteolysis was found to be 1.0-10(5) (aspartate carbamoyltransferase-L). It differs from the native form of the enzyme (aspartate carbamoyltransferase... | Characterization of the aspartate carbamoyltransferase fragment generated by protease action on the pyrimidine-3 gene product of Neurospora crassa. The molecular weight of the fragment of aspartate carbamoyltransferase (carbamoylphosphate: L-aspartate carbamoyltransferase, EC 2.1.3.2) of Neurospora crassa following pro... | [
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PMID:21698 | Differential stabilities of soil enzymes. Assay and properties of phosphatase and arylsulphatase. | Methods have been refined for the assay of phosphatase and arylsulphatase activities in soil, based on the chromogenic p-nitrophenyl ester substrates. Basic assay conditions have been defined, and pH optima and kinetic parameters have been determined. The enzymes follow Michaelis-Menten kinetics; this conclusion is bas... | Differential stabilities of soil enzymes. Assay and properties of phosphatase and arylsulphatase. Methods have been refined for the assay of phosphatase and arylsulphatase activities in soil, based on the chromogenic p-nitrophenyl ester substrates. Basic assay conditions have been defined, and pH optima and kinetic par... | [
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PMID:21699 | Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity. | The specificity and mode of action of an acid proteinase (EC 3.4.23.6) from Aspergillus saitoi were investigated with oxidized B-chain of insulin, angiotensin II and bradykinin. Further purification of acid proteinase was performed with N,O-dibenzyloxycarbonyl-tyrosine hexamethylene-diamino-Sepharose 4B affinity chroma... | Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity. The specificity and mode of action of an acid proteinase (EC 3.4.23.6) from Aspergillus saitoi were investigated with oxidized B-chain of insulin, angiotensin II and bradykinin. Further purification of acid protein... | [
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PMID:21700 | Purification of the tyrosine inhibitable 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Schizosaccharomyces pombe. | A method is described for the purification of the tyrosine inhibitable isoenzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate-lyase(pyruvate phosphorylating), EC 4.1.2.15) to homogeneity as judged by polyacrylamide gel electrophoresis. | Purification of the tyrosine inhibitable 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Schizosaccharomyces pombe. A method is described for the purification of the tyrosine inhibitable isoenzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-... | [
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PMID:21701 | The effect of an NADPH-regenerating system on biphenyl metabolism in isolated rat hepatocytes. | Biphenyl 4-hydroxylation was studied in isolated rat hepatocytes. It was found that there was in inter-relationship between 4-hydroxylase activity and glucuronidase activity, removal of 4-hydroxybiphenyl by conjugation being necessary to stimulate a second phase of hydroxylation. Addition of an NADPH-regenerating syste... | The effect of an NADPH-regenerating system on biphenyl metabolism in isolated rat hepatocytes. Biphenyl 4-hydroxylation was studied in isolated rat hepatocytes. It was found that there was in inter-relationship between 4-hydroxylase activity and glucuronidase activity, removal of 4-hydroxybiphenyl by conjugation being ... | [
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PMID:21702 | Relationship between intramitochondrial citrate and the activity of carbamoyl-phosphate synthase (ammonia). | The possibility of control of the activity of carbamoyl-phosphate synthase (ammonia) (EC 2.7.2.5) in rat-liver mitochondria by variation in the intramitochondrial free Mg2+ concentration has been investigated. Carbamoyl-phosphate synthase activity was measured by coupling the formation of carbamoylphosphate to the synt... | Relationship between intramitochondrial citrate and the activity of carbamoyl-phosphate synthase (ammonia). The possibility of control of the activity of carbamoyl-phosphate synthase (ammonia) (EC 2.7.2.5) in rat-liver mitochondria by variation in the intramitochondrial free Mg2+ concentration has been investigated. Ca... | [
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PMID:21704 | Lectins in the hemolymph of Japanese horseshoe crab, tachypleus tridentatus. | The hemolymph of the Japanese horseshoe crab, Tachypleus tridentatus contains lectins which agglutinate mammalian erythrocytes. Affinity chromatographic purification of the lectins using bovine submaxillary gland mucin-conjugated Sepharose resulted in the separation of the lectins into four fractions; one major and thr... | Lectins in the hemolymph of Japanese horseshoe crab, tachypleus tridentatus. The hemolymph of the Japanese horseshoe crab, Tachypleus tridentatus contains lectins which agglutinate mammalian erythrocytes. Affinity chromatographic purification of the lectins using bovine submaxillary gland mucin-conjugated Sepharose res... | [
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PMID:21705 | Coordination-chemistry study of polypeptides. III. protonation-deprotonation equilibrium study of synthetic alphaH -corticotropin1-32. Data on the pH-dependent conformation of corticotropin. | By potentiometric equilibrium measurements and the computer evaluation of experimental data, the protonation equilibrium constants of four fragments of corticotropin (ACTH), ACTH1-32. ACTH1-28, ACTH1-14 and ACTH1-4, were determined and assigned to the corresponding functional groups. From the dependence of the protonat... | Coordination-chemistry study of polypeptides. III. protonation-deprotonation equilibrium study of synthetic alphaH -corticotropin1-32. Data on the pH-dependent conformation of corticotropin. By potentiometric equilibrium measurements and the computer evaluation of experimental data, the protonation equilibrium constant... | [
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PMID:21706 | [Studies of basic proteins of 60S- and 40S-subunits of pea seed ribosomes by two-dimensional polyacrylamide gel electrophoresis]. | Basic proteins of 60S- and 40S-subunits of pea seed ribosomes were studied by two-dimensional electrophoresis in polyacrylamide gel (PAAG) with subsequent electrophoresis of separated proteins in the gels containing sodium dodecyl sulfate. The proteins under study were found to be electrophoretically heterogenous and s... | [Studies of basic proteins of 60S- and 40S-subunits of pea seed ribosomes by two-dimensional polyacrylamide gel electrophoresis]. Basic proteins of 60S- and 40S-subunits of pea seed ribosomes were studied by two-dimensional electrophoresis in polyacrylamide gel (PAAG) with subsequent electrophoresis of separated protei... | [
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PMID:21709 | Recent developments in the biochemistry of globoid and metachromatic leucodystrophies. | Galactosylceramides and their sulphates are the main constituents of myelin sheath of the nerve cell. Two genetically determined disorders are the results of an inability to enzymatically hydrolyse these glycolipids. Thus the deficiency of galactosylceramide beta-galactosidase results in globoid cell leucodystrophy and... | Recent developments in the biochemistry of globoid and metachromatic leucodystrophies. Galactosylceramides and their sulphates are the main constituents of myelin sheath of the nerve cell. Two genetically determined disorders are the results of an inability to enzymatically hydrolyse these glycolipids. Thus the deficie... | [
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PMID:21710 | In-vitro and in-vivo properties of canine blood mononuclear leukocytes separated by discontinuous albumin density gradient centrifugation. | Dogs were given 1 200 R whole body x-irradiation and transfused with frozen and thawed mononuclear leukocytes from a DLA identical, MLC negative donor dog. These leukocytes had been obtained from the peripheral blood by means of leukapheresis, using the IBM experimental cell separator after injection of 15 mg/kg body w... | In-vitro and in-vivo properties of canine blood mononuclear leukocytes separated by discontinuous albumin density gradient centrifugation. Dogs were given 1 200 R whole body x-irradiation and transfused with frozen and thawed mononuclear leukocytes from a DLA identical, MLC negative donor dog. These leukocytes had been... | [
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PMID:21711 | Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle. | Sodium currents were studied under voltage clamp in the presence of neutral, amine, and quaternary local anesthetic compounds. Use-dependent block was observed as a cumulative depression of INa seen with repetitive depolarizing test pulses applied at frequencies of 2-10s-1. With quaternary QX-314, the time constant of ... | Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle. Sodium currents were studied under voltage clamp in the presence of neutral, amine, and quaternary local anesthetic compounds. Use-dependent block was observed as a cumulative depression of INa seen with repetitive depolarizing te... | [
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PMID:21713 | The effect of acid pH on the growth kinetics of Trichoderma viride. | Batch cultures of Trichoderma viride have been carried out in a 10 liter stirred fermenter a controlled pH values of 2.5, 2.7, 3.0, and 4.0 and without pH control at a temperature of 28 degrees C. Cell and glucose concentrations and dissolved oxygen values are reported. The yield coefficient was found to be constant at... | The effect of acid pH on the growth kinetics of Trichoderma viride. Batch cultures of Trichoderma viride have been carried out in a 10 liter stirred fermenter a controlled pH values of 2.5, 2.7, 3.0, and 4.0 and without pH control at a temperature of 28 degrees C. Cell and glucose concentrations and dissolved oxygen va... | [
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PMID:21714 | Preparation and properties of immobilized papain and lipase. | Papain and lipase were immobilized on derivatized Sepharose 4-B. The activated agarose had a binding capacity of 1.2 micronmol amino groups/ml packed agarose or 17 mg proteins/g dry agarose. The immobilized enzyme preparations were tested for the effects of pH of assay, temperature of assay, and substrate concentration... | Preparation and properties of immobilized papain and lipase. Papain and lipase were immobilized on derivatized Sepharose 4-B. The activated agarose had a binding capacity of 1.2 micronmol amino groups/ml packed agarose or 17 mg proteins/g dry agarose. The immobilized enzyme preparations were tested for the effects of p... | [
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PMID:21715 | Development of hematopoietic spleen colonies in nonirradiated genetically normal mice. | The question as to whether prior irradiation or injection of cytotoxic drugs is essential for the development of spleen colonies was examined in genetically normal mice. Mixtures of lymph node and bone marrow cells from C57BL mice were injected into (C57BL X CBA-T6T6) F1 hybrid mice without pretreatment. Hematopoietic ... | Development of hematopoietic spleen colonies in nonirradiated genetically normal mice. The question as to whether prior irradiation or injection of cytotoxic drugs is essential for the development of spleen colonies was examined in genetically normal mice. Mixtures of lymph node and bone marrow cells from C57BL mice we... | [
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PMID:21720 | Further studies of sulphasalazine metabolism in the treatment of ulcerative colitis. | Sixty-four outpatients with ulcerative colitis receiving maintenance treatment with sulphasalazine were studied to relate disease activity to serum concentrations of sulphapyridine. Of 43 patients in remission, 32 had serum sulphapyridine levels over 20 microgram/ml. Ten of the 21 patients with active disease were for ... | Further studies of sulphasalazine metabolism in the treatment of ulcerative colitis. Sixty-four outpatients with ulcerative colitis receiving maintenance treatment with sulphasalazine were studied to relate disease activity to serum concentrations of sulphapyridine. Of 43 patients in remission, 32 had serum sulphapyrid... | [
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PMID:21726 | Quinonoid dihydropterin reductase from beef liver. | Quinonoid dihydropterin reductase has been purified from beef liver. This enzyme has been shown to be indistinguishable from the reductase of sheep liver in molecular weight, subunit composition, and terminal residues. Both beef and sheep liver reductases possess acyl isoleucine as the N-terminal residue. Use of improv... | Quinonoid dihydropterin reductase from beef liver. Quinonoid dihydropterin reductase has been purified from beef liver. This enzyme has been shown to be indistinguishable from the reductase of sheep liver in molecular weight, subunit composition, and terminal residues. Both beef and sheep liver reductases possess acyl ... | [
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PMID:21727 | Isolation and properties of a glycerophosphate acylating fraction in the fat body of Schistocerca gregaria (Forskäl). | An acyl-CoA-L-alpha-glycerophosphate acyltransferase system has been found in the fat body of the locust Schistocerca gregaria (Forskäl). After homogenization and differential centrifugation the enzyme system has been localized in two distinct particulate fractions. In both fractions phosphatidic acid was the main reac... | Isolation and properties of a glycerophosphate acylating fraction in the fat body of Schistocerca gregaria (Forskäl). An acyl-CoA-L-alpha-glycerophosphate acyltransferase system has been found in the fat body of the locust Schistocerca gregaria (Forskäl). After homogenization and differential centrifugation the enzyme ... | [
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PMID:21728 | Heterogeneity of alkaline ribonuclease in the mouse and Ehrlich ascites cells. | The specific activity of alkaline RNase II was l00 to 1800 times higher in mouse pancreas than in mouse liver, serum, ascites fluid, and Ehrlich ascites cell grown intraperitoneally. Ehrlich ascites cells grown in cell culture medium had a much lower alkaline RNase II activity than cells grown intraperitoneally. Chroma... | Heterogeneity of alkaline ribonuclease in the mouse and Ehrlich ascites cells. The specific activity of alkaline RNase II was l00 to 1800 times higher in mouse pancreas than in mouse liver, serum, ascites fluid, and Ehrlich ascites cell grown intraperitoneally. Ehrlich ascites cells grown in cell culture medium had a m... | [
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PMID:21730 | An analysis of the action of lanthanum on aortic tissue from normotensive and spontaneously hypertensive rats. | Significant tension development resulting from the administration of lanthanum salts (La3+) to isolated aorta tissues was observed in preparations from the spontaneously hypertensive rat (SHR) but not in preparation from age-matched normotensive Wistar rats (NWR). The response to La3+ was significantly greater in tissu... | An analysis of the action of lanthanum on aortic tissue from normotensive and spontaneously hypertensive rats. Significant tension development resulting from the administration of lanthanum salts (La3+) to isolated aorta tissues was observed in preparations from the spontaneously hypertensive rat (SHR) but not in prepa... | [
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PMID:21732 | Role of transmitters in mediating hypothalamic control of electrolyte excretion. | Changes in urinary volume and electrolyte excretion were monitored after the injection of cholinergic and monoaminergic drugs into the third cerebral ventricle of conscious male rats made diuretic by an intravenous infusion of 5% dextrose. A natriuretic and kaliuretic response was induced by the intraventricular inject... | Role of transmitters in mediating hypothalamic control of electrolyte excretion. Changes in urinary volume and electrolyte excretion were monitored after the injection of cholinergic and monoaminergic drugs into the third cerebral ventricle of conscious male rats made diuretic by an intravenous infusion of 5% dextrose.... | [
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PMID:21733 | Bile-salt-dependent and independent choleresis induced by bucolome in the rat. | Choleresis induced by bucolome (BC) (1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine) was studied in male Wistar rats. [14C]Erythritol and mannitol clearance studies indicated this choleresis to be of canalicular origin. In 1-h continuous bile collection studies, immediately after the interruption of enterohepati... | Bile-salt-dependent and independent choleresis induced by bucolome in the rat. Choleresis induced by bucolome (BC) (1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydropyrimidine) was studied in male Wistar rats. [14C]Erythritol and mannitol clearance studies indicated this choleresis to be of canalicular origin. In 1-h continu... | [
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PMID:21735 | Regulation of pyruvate kinases from Fusarium oxysporum. | Two types of pyruvate kinases were found in Fusarium oxysporum. One type (inducible) was present mainly during the early stages of growth on glucose or sucrose and displayed Michaelis-Menten kinetics with respect to phosphoenolpyruvate and adenosine diphosphate. The major type (constitutive) was present under all condi... | Regulation of pyruvate kinases from Fusarium oxysporum. Two types of pyruvate kinases were found in Fusarium oxysporum. One type (inducible) was present mainly during the early stages of growth on glucose or sucrose and displayed Michaelis-Menten kinetics with respect to phosphoenolpyruvate and adenosine diphosphate. T... | [
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PMID:21736 | The effect of different nitrogen sources on pigment production and sporulation of Monascus species in submerged, shaken culture. | Thirty-nine strains from the genus Monascus were cultivated aerobically to study the relation between nitrogen nutrition and sporulation and pigment production. The effects of yeast extract, nitrate, ammonium, and ammonium nitrate have been compared. During cultivation the pHs of the different media are not the same, r... | The effect of different nitrogen sources on pigment production and sporulation of Monascus species in submerged, shaken culture. Thirty-nine strains from the genus Monascus were cultivated aerobically to study the relation between nitrogen nutrition and sporulation and pigment production. The effects of yeast extract, ... | [
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PMID:21737 | Physiological and biochemical studies on senescing tap root nodules of soybeans. | Senescence of soybean (Glycine max L. Merr.) tap root nodules was investigated by comparing changes in various physiological and biochemical activities with changes in capacity to fix nitrogen. Field-grown Beeson and Calland varieties of soybeans of various ages were sources of tap root nodules. With both varieties, t... | Physiological and biochemical studies on senescing tap root nodules of soybeans. Senescence of soybean (Glycine max L. Merr.) tap root nodules was investigated by comparing changes in various physiological and biochemical activities with changes in capacity to fix nitrogen. Field-grown Beeson and Calland varieties of ... | [
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PMID:21738 | Influence of acetohydroxamic acid on experimental Corynebacterium renale pyelonephritis. | The role of Corynebacterium renale urease in the establishment of pyelonephritis was studied by the oral administration of acetohydroxamic acid (AHA), a urease inhibitor, to experimentally infected rats. The bacteria were introduced by surgical insertion of a zinc disc containing 1 X 10(6) colony-forming units of C-ren... | Influence of acetohydroxamic acid on experimental Corynebacterium renale pyelonephritis. The role of Corynebacterium renale urease in the establishment of pyelonephritis was studied by the oral administration of acetohydroxamic acid (AHA), a urease inhibitor, to experimentally infected rats. The bacteria were introduce... | [
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PMID:21739 | Metabolism of mandelic acid by Neurospora crassa. | Preliminary studies on the metabolism of manelic acid by Neurospora crassa reveal the operation of a pathway for its degradation which involves benzoyl formic acid, benzaldehyde, benzoic acid, 4-hydroxybenzoic acid, and protocatechuic acid as the intermediates. This pathway is different from the followed by bacterial s... | Metabolism of mandelic acid by Neurospora crassa. Preliminary studies on the metabolism of manelic acid by Neurospora crassa reveal the operation of a pathway for its degradation which involves benzoyl formic acid, benzaldehyde, benzoic acid, 4-hydroxybenzoic acid, and protocatechuic acid as the intermediates. This pat... | [
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PMID:21742 | The identification of individuals at high risk for large bowel cancer: an overview. | Attempts to identify individuals with increased susceptibility to colon cancer before clinical manifestations of disease, have recently been made. Early stages of abnormal growth of colonic epithelial cells, and related factors that may contribute to the development of colonic neoplasia have been shown. Based on the id... | The identification of individuals at high risk for large bowel cancer: an overview. Attempts to identify individuals with increased susceptibility to colon cancer before clinical manifestations of disease, have recently been made. Early stages of abnormal growth of colonic epithelial cells, and related factors that may... | [
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PMID:21743 | Activation of the guanylate cyclase-guanosine 3'5' monophosphate system of colonic mucosa by n-methyl-n'-nitro-n-nitrosoguanidine. | The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 +/- 0.2 to 22.5 +/- 2.7 pmol/mg protein in 5 minutes. Increases in response to MNNG occurred in the ... | Activation of the guanylate cyclase-guanosine 3'5' monophosphate system of colonic mucosa by n-methyl-n'-nitro-n-nitrosoguanidine. The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased... | [
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PMID:21744 | Phospholipases A1 and A2 in subcellular fractions and plasma membranes of Krebs II ascites cells. | A method is described for the localization and characterization of phospholipases A1 and A2 (EC3.1.1.4) in Krebs II ascites cells, particularly in the plasma membranes. Cells were lysed with a Dounce homogenizer in an isotonic sucrose medium. Plasma membranes sediment with mitochondria and lysosomes during subcellular ... | Phospholipases A1 and A2 in subcellular fractions and plasma membranes of Krebs II ascites cells. A method is described for the localization and characterization of phospholipases A1 and A2 (EC3.1.1.4) in Krebs II ascites cells, particularly in the plasma membranes. Cells were lysed with a Dounce homogenizer in an isot... | [
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PMID:21745 | Selective tumor DNA synthesis inhibition: in vivo prodrug activation by an exogenous enzyme. | Using the combination of alpha-L-arabinofuranosidase from Aspergillus niger with beta-peltatin A-alpha-L-arabinofuranoside, the selective effect of a new cancer of chemotherapy method based on a pH-dependent activation of cancerostatic prodrugs by exogenous enzymes was studied. In comparative experiments the selectivit... | Selective tumor DNA synthesis inhibition: in vivo prodrug activation by an exogenous enzyme. Using the combination of alpha-L-arabinofuranosidase from Aspergillus niger with beta-peltatin A-alpha-L-arabinofuranoside, the selective effect of a new cancer of chemotherapy method based on a pH-dependent activation of cance... | [
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PMID:21746 | Evidence for new catecholamines or related amino acids in some invertebrate sensory neurons. | In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Artemia salina, fluorophores are formed during the course of the fluorescent histochemical technique of Falck-Hillarp. The presumed catecholamine nature of the neuronal fl... | Evidence for new catecholamines or related amino acids in some invertebrate sensory neurons. In certain sensory neurons of many different invertebrate species, including the sea anemones. Metridium senile and Tealia felina and the crustacean Artemia salina, fluorophores are formed during the course of the fluorescent h... | [
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PMID:21748 | The induction of sister chromatid exchanges by cyclophosphamide in the presence of differently induced microsomal fractions of rat liver. | The induction of sister chromatid exchanges can be monitored by a test that incorporates the factor of metabolic activation in a simple manner. The results with cyclophosphamide show that in this test the induction of the metabolizing enzymes of the rat liver homogenates used is very important. 3-Methylcholanthrene ind... | The induction of sister chromatid exchanges by cyclophosphamide in the presence of differently induced microsomal fractions of rat liver. The induction of sister chromatid exchanges can be monitored by a test that incorporates the factor of metabolic activation in a simple manner. The results with cyclophosphamide show... | [
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... |
PMID:21754 | [A gas chromatographic study of the composition of neutral and amino sugars in two neuraminidases, of bacterial and viral origin]. | The neutral and aminosugar composition has been determined by gas-liquid chromatography for two neuraminidases, either bacterial, from Streptococcus pneumoniae, or viral, from Myxovirus influenzae A/Hong Kong/1/68. | [A gas chromatographic study of the composition of neutral and amino sugars in two neuraminidases, of bacterial and viral origin]. The neutral and aminosugar composition has been determined by gas-liquid chromatography for two neuraminidases, either bacterial, from Streptococcus pneumoniae, or viral, from Myxovirus inf... | [
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PMID:21755 | [Action of toxins isolated from scorpion and sea anemone venoms on ileum isolated from reserpine-treated guinea pigs]. | We have shown that the ileum isolated from a reserpinized guinea Pig does respond to toxin II obtained from Scorpion venom but does not react to Anemonia sulcata toxin. We conclude that if Acetylcholine is the neurotransmitter inducing pharmacological activity of Scorpion toxin it is serotonin which triggers activity o... | [Action of toxins isolated from scorpion and sea anemone venoms on ileum isolated from reserpine-treated guinea pigs]. We have shown that the ileum isolated from a reserpinized guinea Pig does respond to toxin II obtained from Scorpion venom but does not react to Anemonia sulcata toxin. We conclude that if Acetylcholin... | [
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PMID:21756 | Lysosomal and ATP changes after renal-stalk clamping in rats. I. Protective action of Trasylol. | The action of Trasylol on the lysosomal and ATP changes after renal-stalk clamping in rats was examined. It was found that, in the presence of an effective Trasylol concentration, a distinct stabilization of the lysosomal membrane can be detected after 30 min of renal-stalk clamping. It was also found that there is onl... | Lysosomal and ATP changes after renal-stalk clamping in rats. I. Protective action of Trasylol. The action of Trasylol on the lysosomal and ATP changes after renal-stalk clamping in rats was examined. It was found that, in the presence of an effective Trasylol concentration, a distinct stabilization of the lysosomal me... | [
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PMID:21757 | Humoral factors in shock causing bradycardia and myocardial depression. | Hypovolemic shock was maintained for 6 hours in dogs in which the heart was hemodynamically protected by a biological model described earlier. Blood of these dogs was exchanged with that of healthy dogs in which myocardial tension and heart rate were continuously monitored. It was found that rate and force of decline i... | Humoral factors in shock causing bradycardia and myocardial depression. Hypovolemic shock was maintained for 6 hours in dogs in which the heart was hemodynamically protected by a biological model described earlier. Blood of these dogs was exchanged with that of healthy dogs in which myocardial tension and heart rate we... | [
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PMID:21758 | A possible change in the rate-limiting step for cardiac norepinephrine synthesis in the cardiomyopathic Syrian hamster. | The development of heart failure in the cardiomyopathic hamster is associated with a decrease in norepinephrine stores and parallel increases in cardiac sympathetic tone and tyrosine hydroxylase activity. Despite the increase in tyrosine hydroxylase, cardiac norepinephrine synthesis does not increase in heart failure. ... | A possible change in the rate-limiting step for cardiac norepinephrine synthesis in the cardiomyopathic Syrian hamster. The development of heart failure in the cardiomyopathic hamster is associated with a decrease in norepinephrine stores and parallel increases in cardiac sympathetic tone and tyrosine hydroxylase activ... | [
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PMID:21760 | Natural history and classification of occlusive thromboaortopathy (Takayasu's disease). | Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compli... | Natural history and classification of occlusive thromboaortopathy (Takayasu's disease). Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplic... | [
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PMID:21761 | Effectiveness of an outpatient urine screening program. | We evaluated the effectiveness of a routine outpatient urinalysis screening program on a sample population of 2600 patients. The 189 abnormal urine results found in 182 patients were followed up by study of any new clinical and laboratory investigations or therapeutic modifications initiated on the basis of any abnorma... | Effectiveness of an outpatient urine screening program. We evaluated the effectiveness of a routine outpatient urinalysis screening program on a sample population of 2600 patients. The 189 abnormal urine results found in 182 patients were followed up by study of any new clinical and laboratory investigations or therape... | [
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PMID:21762 | Criteria for establishing a standardized method for determining alkaline phosphatase activity in human serum. | We investigated factors influencing alkaline phosphatase activity in the course of developing criteria for the establishment of a standardized method for its determination in human serum at 30 degrees C. The effects of pH, phosphorylatable acceptor (2-amino-2-methyl-1-propanol and diethanolamine), 4-nitrophenyl phospha... | Criteria for establishing a standardized method for determining alkaline phosphatase activity in human serum. We investigated factors influencing alkaline phosphatase activity in the course of developing criteria for the establishment of a standardized method for its determination in human serum at 30 degrees C. The ef... | [
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PMID:21763 | Improved hydrolysis of urinary 17-hydroxycorticosteroid glucuronides with beta-glucuronidase from Helix pomatia, on adding sodium sulfate. | Sodium sulfate increases the hydrolysis of urinary 17-hydroxycorticosteroid glucuronides with beta-glucuronidase preparations derived from Helix pomatia because it removes the inhibitory activity of urinary high-molecular-weight substances. For maximum hydrolysis of urinary 17-hydroxycorticosteroid glucuronides, the hy... | Improved hydrolysis of urinary 17-hydroxycorticosteroid glucuronides with beta-glucuronidase from Helix pomatia, on adding sodium sulfate. Sodium sulfate increases the hydrolysis of urinary 17-hydroxycorticosteroid glucuronides with beta-glucuronidase preparations derived from Helix pomatia because it removes the inhib... | [
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PMID:21764 | Use of an enzymatic kit method for cholesterol, designed for continuous-flow instrumentation, with discrete bichromatic and centrifugal analyzers. | I examined a cholesterol-assay kit ("Autoflo", Biodynamics/bmc) designed for use with continuous-flow instrumentation for its use with some discrete analyzers. At pH 7.2, color develops within 3 min upon exposure to cholesterol, then begins to fade. At pH 8, the color develops more slowly but remains stable for at leas... | Use of an enzymatic kit method for cholesterol, designed for continuous-flow instrumentation, with discrete bichromatic and centrifugal analyzers. I examined a cholesterol-assay kit ("Autoflo", Biodynamics/bmc) designed for use with continuous-flow instrumentation for its use with some discrete analyzers. At pH 7.2, co... | [
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PMID:21765 | Oxidation of alpha-hydroxybutyrate by human serum. | 2-Hydroxybutyrate is enzymically oxidized by the LDH of human serum. Optimal concentrations of hydrogen ion, substrate and coenzyme for this oxidation by sera from patients with disease of the heart or liver have been determined at 37 degrees C. The linearity of this reaction is limited to a point at which an assay pro... | Oxidation of alpha-hydroxybutyrate by human serum. 2-Hydroxybutyrate is enzymically oxidized by the LDH of human serum. Optimal concentrations of hydrogen ion, substrate and coenzyme for this oxidation by sera from patients with disease of the heart or liver have been determined at 37 degrees C. The linearity of this r... | [
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PMID:21768 | Salivary excretion and pharmacokinetics of sulfapyridine after sulfasalazine. | The concentrations of sulfapyridine (SP) and N4-acetylsulfapyridine (AcSP) in the plasma and saliva of 5 healthy male adults (3 slow and 2 rapid acetylators) were determined as a function of time after a single 2.0-gm oral dose of sulfasalazine (salicylazosulfapyridine). SP absorption commenced 3.5 to 6 hr after sulfas... | Salivary excretion and pharmacokinetics of sulfapyridine after sulfasalazine. The concentrations of sulfapyridine (SP) and N4-acetylsulfapyridine (AcSP) in the plasma and saliva of 5 healthy male adults (3 slow and 2 rapid acetylators) were determined as a function of time after a single 2.0-gm oral dose of sulfasalazi... | [
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PMID:21770 | Enzymes of Penicillium roqueforti involved in the biosynthesis of cheese flavor. | The ripening of blue and Roquefort cheeses is accomplished by the concerted and controlled actions of enzymes of the mold Penicillium roqueforti. The properties and effects of the enzymes involved in flavor development (i.e., proteases, lipase and beta-ketoacid decarboxylase) are reviewed. The metabolic activities of b... | Enzymes of Penicillium roqueforti involved in the biosynthesis of cheese flavor. The ripening of blue and Roquefort cheeses is accomplished by the concerted and controlled actions of enzymes of the mold Penicillium roqueforti. The properties and effects of the enzymes involved in flavor development (i.e., proteases, li... | [
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PMID:21771 | Carfecillin: antibacterial activity in vitro and in vivo. | Carfecillin, the alpha-phenyl ester of carbenicillin, hydrolyses rapidly in the presence of serum or body tissues to liberate carbenicillin but hydrolysis is less rapid in aqueous solution. The activity of carfecillin in antibacterial tests in vitro depends upon the extent of hydrolysis to carbenicillin, and in convent... | Carfecillin: antibacterial activity in vitro and in vivo. Carfecillin, the alpha-phenyl ester of carbenicillin, hydrolyses rapidly in the presence of serum or body tissues to liberate carbenicillin but hydrolysis is less rapid in aqueous solution. The activity of carfecillin in antibacterial tests in vitro depends upon... | [
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PMID:21773 | Urinary excretion pattern of methaqualone metabolites in man. | A method based on selected ion monitoring for determination of five monohydroxy metabolites of methaqualone in urine has been worked out. By means of this method the time course of metabolite excretion was studied in three healthy volunteers receiving an oral therapeutic dose of methaqualone. In all subjects the main m... | Urinary excretion pattern of methaqualone metabolites in man. A method based on selected ion monitoring for determination of five monohydroxy metabolites of methaqualone in urine has been worked out. By means of this method the time course of metabolite excretion was studied in three healthy volunteers receiving an ora... | [
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PMID:21775 | Metabolism of sulfadimidine, sulfanilamide, p-aminobenzoic acid, and isoniazid in suspensions of parenchymal and nonparenchymal rat liver cells. | Suspensions of isolated liver cells were prepared from rat livers perfused with Ca++-free buffer and 0.05% collagenase. Primary cell suspensions (containing both parenchymal and nonparenchymal liver cells) metabolized sulfadimidine, sulfanilamide, p-aminobenzoic acid, and isoniazid approximately at first order kinetics... | Metabolism of sulfadimidine, sulfanilamide, p-aminobenzoic acid, and isoniazid in suspensions of parenchymal and nonparenchymal rat liver cells. Suspensions of isolated liver cells were prepared from rat livers perfused with Ca++-free buffer and 0.05% collagenase. Primary cell suspensions (containing both parenchymal a... | [
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PMID:21776 | The metabolism of drugs in isolated rat hepatocytes. A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions. | The metabolism of drugs in isolated rat hepatocytes has been investigated. Drugs which are metabolized by aromatic hydrolation, aliphatic hydroylation, N-demethylation, or glucuronidation have been used as substrates. With some substrates the rate of metabolism in isolated hepatocytes compares with that in hepatic 900g... | The metabolism of drugs in isolated rat hepatocytes. A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions. The metabolism of drugs in isolated rat hepatocytes has been investigated. Drugs which are metabolized by aromatic hydrolation, aliphatic hydroylation, N-demethylation, or g... | [
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PMID:21777 | Comparative metabolism of four allylic barbiturates and hexobarbital by the rat and guinea pig. | A method for the extraction and identification of urinary metabolites of allylic barbiturates by gas chromatography and mass spectrometry is described. The metabolites from rat and guinea pig urine were extracted and separated into two fractions (an acidic and a nonacidic fraction) by chromatography on DEAE-Sephadex be... | Comparative metabolism of four allylic barbiturates and hexobarbital by the rat and guinea pig. A method for the extraction and identification of urinary metabolites of allylic barbiturates by gas chromatography and mass spectrometry is described. The metabolites from rat and guinea pig urine were extracted and separat... | [
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PMID:21778 | Disposition of triazolam, 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a]benzodiazepine, in the dog. | Disposition of triazolam (T), a new, potent, hypnotic agent, was studied in the dog. A single 0.5-mg/kg oral or iv dose of 14C-labeled T was rapidly absorbed, and although 88% was bound to serum proteins, T levels decreased with a half-life of 0.85 hr. Metabolism of T was rapid, with a first-pass effect observed after ... | Disposition of triazolam, 8-chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a]benzodiazepine, in the dog. Disposition of triazolam (T), a new, potent, hypnotic agent, was studied in the dog. A single 0.5-mg/kg oral or iv dose of 14C-labeled T was rapidly absorbed, and although 88% was bound to serum proteins, T le... | [
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PMID:21783 | [Maridi haemorrhgic fever: a new viral disease (author's transl)]. | A new viral disease (Maridi haemorrhagic fever) occurred in the South Sudan in 1976. It was obviously identical with an epidemic which occurred at the same time in Zaire. The virus is morpologically closely similar to the Marburg virus. During the Maridi epemic 124 of 238 patients died (52%). Characteristic symptoms we... | [Maridi haemorrhgic fever: a new viral disease (author's transl)]. A new viral disease (Maridi haemorrhagic fever) occurred in the South Sudan in 1976. It was obviously identical with an epidemic which occurred at the same time in Zaire. The virus is morpologically closely similar to the Marburg virus. During the Marid... | [
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PMID:21780 | Studies on isometheptene metabolism. Identification and stereochemistry of a major metabolite isolated from rat urine. | By gas chromatography-mass spectrometry of both underivatized samples and N-acetates, the major urinary metabolite of the antispasmodic drug (+/-)-isometheptene in the rat was identified as trans-2-methyl-6-methylamino-2-hepten-1-ol. The structure and stereochemistry of the metabolites was confirmed by comparing the pr... | Studies on isometheptene metabolism. Identification and stereochemistry of a major metabolite isolated from rat urine. By gas chromatography-mass spectrometry of both underivatized samples and N-acetates, the major urinary metabolite of the antispasmodic drug (+/-)-isometheptene in the rat was identified as trans-2-met... | [
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PMID:21785 | [Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists (author's transl)]. | Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four patients after treatment lasting from six weeks to four-and-a-half-months. Two patients developed recurrent ulcer after the ... | [Treatment of peptic ulcer in the Zollinger-Ellison syndrome with histamine H2-receptor antagonists (author's transl)]. Histamine H2-receptor antagonists metiamide and cimetidine were used in the treatment of severe peptic ulceration in Zollinger-Ellison syndrome. The ulcerations were completely healed in all four pati... | [
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PMID:21786 | [Minoxidil in the treatment of malignant hypertension (author's transl)]. | In 21 of 23 patients with hypertension unresponsive to other treatment minoxidil, a new antihypertensive drug acting via peripheral vasodilatation, lowered their blood pressure from 191 +/- 19/117 +/- 12 MM Hg to 147 +/- 13/117 +/- 12 mm Hg. The drug causes a reflex tachycardia and must therefore be combined with beta-... | [Minoxidil in the treatment of malignant hypertension (author's transl)]. In 21 of 23 patients with hypertension unresponsive to other treatment minoxidil, a new antihypertensive drug acting via peripheral vasodilatation, lowered their blood pressure from 191 +/- 19/117 +/- 12 MM Hg to 147 +/- 13/117 +/- 12 mm Hg. The ... | [
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PMID:21782 | The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide in mice and rats. | The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA; NSC-141549), a new antitumor agent presently under consideration for phase I evaluation in man, was studied in mice and rats with 14C-AMSA labeled in the 9-carbon of the acridine ring. Radioactivity was selectively localized in the l... | The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide in mice and rats. The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide (AMSA; NSC-141549), a new antitumor agent presently under consideration for phase I evaluation in man, was studied in mice and rats with 14C-A... | [
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PMID:21787 | [Defluoridation of household water]. | Fluorine enriched drinking water (1 ppm F-) is partially defluoridated with the aid of a simple (laboratory) apparatus. The material employed is tricalcium phosphate. The pH-values and electrical conductivity due to fluoridation are significantly changed by defluoridation. The duration of the defluoridation process app... | [Defluoridation of household water]. Fluorine enriched drinking water (1 ppm F-) is partially defluoridated with the aid of a simple (laboratory) apparatus. The material employed is tricalcium phosphate. The pH-values and electrical conductivity due to fluoridation are significantly changed by defluoridation. The durat... | [
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PMID:21788 | [Local anesthesia and beta receptor blockers in dentistry. (Study on an injectable combination of lidocaine and betadrenol)]. | A double blind trial was undertaken to determine whether the addition of the beta-receptor blocker Betadrenol in two different doses to a lidocaine solution containing adrenaline could influence the exogenous and endogenous beta-adrenergic effects in the field of dental interventions under local anesthesia. It could be... | [Local anesthesia and beta receptor blockers in dentistry. (Study on an injectable combination of lidocaine and betadrenol)]. A double blind trial was undertaken to determine whether the addition of the beta-receptor blocker Betadrenol in two different doses to a lidocaine solution containing adrenaline could influence... | [
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PMID:21789 | [Effects of clonazepam taken per os by children with rebellious epileptic encephalopathies]. | The effect of clonazepam, taken per-os and in very progressive doses, has been studied by the authors on fourteen children afflicted with evolutive epileptic encephalopathies and still presenting, in spite of heavy anti-epileptic polychemio-therapies, alarming clinical and electrical manifestations. Clonazepam proved t... | [Effects of clonazepam taken per os by children with rebellious epileptic encephalopathies]. The effect of clonazepam, taken per-os and in very progressive doses, has been studied by the authors on fourteen children afflicted with evolutive epileptic encephalopathies and still presenting, in spite of heavy anti-epilept... | [
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PMID:21790 | Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH-dependent glutamate synthase from lupin nodules. | An NADH-dependent glutamate synthase has been purified 500-fold from the plant cytoplasm fraction of Lupinus angustifolius nodules. It consists of a single polypeptide chain, Mr 235000. The optimum pH is 8.5, at which Km values for 2-oxoglutarate, glutamine and NADH are 39 micrometer, 400 micrometer and 1.3 micrometer... | Enzymes of nitrogen metabolism in legume nodules. Purification and properties of NADH-dependent glutamate synthase from lupin nodules. An NADH-dependent glutamate synthase has been purified 500-fold from the plant cytoplasm fraction of Lupinus angustifolius nodules. It consists of a single polypeptide chain, Mr 235000.... | [
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PMID:21791 | Immobilization of yeast microbodies by inclusion with photo-crosslinkable resins. | Yeast microbodies containing FAD-dependent alcohol oxidase, catalase and D-amino acid oxidase were isolated from methanol-grown cells of Kloeckera sp. 2201 and immobilized intact in matrices formed by a short-time illumination of photo-crosslinkable resin oligomers. The relative activities of catalase, alcohol oxidase ... | Immobilization of yeast microbodies by inclusion with photo-crosslinkable resins. Yeast microbodies containing FAD-dependent alcohol oxidase, catalase and D-amino acid oxidase were isolated from methanol-grown cells of Kloeckera sp. 2201 and immobilized intact in matrices formed by a short-time illumination of photo-cr... | [
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PMID:21792 | Energy requirements for maltose transport in yeast. | Maltose transport in yeast (Saccharomyces cerevisiae) is inhibited by uncouplers under conditions where the intracellular concentration of the sugar is lower than in the medium. The uncouplers did not deplete the ATP content of the yeast cells and a 50--100-fold reduction in ATP caused by antimycin and 2-deoxyglucose h... | Energy requirements for maltose transport in yeast. Maltose transport in yeast (Saccharomyces cerevisiae) is inhibited by uncouplers under conditions where the intracellular concentration of the sugar is lower than in the medium. The uncouplers did not deplete the ATP content of the yeast cells and a 50--100-fold reduc... | [
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PMID:21794 | Early biochemical and hemodynamic changes after operation in a bloodless field. | Biochemical and hemodynamic changes during and after operation in a bloodless field have been investigated in 13 patients. The patients were athletes between the age of 21 and 38 years who were healthy except for an inveterate ligament injury of the knee joint. Capillary blood flow in the tibialis anterior muscle was m... | Early biochemical and hemodynamic changes after operation in a bloodless field. Biochemical and hemodynamic changes during and after operation in a bloodless field have been investigated in 13 patients. The patients were athletes between the age of 21 and 38 years who were healthy except for an inveterate ligament inju... | [
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PMID:21797 | Acute acetylsalicylic acid poisoning: treatment with forced alkaline diuresis and diuretics. | 101 patients were treated for acute acetylsalicylic acid (ASA) poisoning in the Nephrological Unit Trondheim between 1971-1975. On admission 33 of them had a serum salicylic acid (SA) concentration greater than 400 microgram/ml (mean 588 +/- 40 microgram/ml). This group was compared with a group of 11 children less tha... | Acute acetylsalicylic acid poisoning: treatment with forced alkaline diuresis and diuretics. 101 patients were treated for acute acetylsalicylic acid (ASA) poisoning in the Nephrological Unit Trondheim between 1971-1975. On admission 33 of them had a serum salicylic acid (SA) concentration greater than 400 microgram/ml... | [
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PMID:21798 | Autacoid and anaphylactic reactivity of pulmonary and hepatic smooth musculature of the cat. | Histamine, 2-methylhistamine (2-MeH: a relatively specific H1 receptor agonist), 5-HT, carbachol, bradykinin (BK) and PGF2alpha contract isolated cat pulmonary vein, artery and hepatic vein. PGE1, PGF2alpha and 4-methylhistamine (4-MeH: a relatively specific H2-receptor agonist) contract pulmonary arterial strips but f... | Autacoid and anaphylactic reactivity of pulmonary and hepatic smooth musculature of the cat. Histamine, 2-methylhistamine (2-MeH: a relatively specific H1 receptor agonist), 5-HT, carbachol, bradykinin (BK) and PGF2alpha contract isolated cat pulmonary vein, artery and hepatic vein. PGE1, PGF2alpha and 4-methylhistamin... | [
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PMID:21799 | Effects of histamine on the human penis muscle in vitro. | Histamine produced three types of effects on corpus cavernosa muscle of the human penis: contraction, relaxation or a contraction followed by a relaxation. 2-Methylhistamine, which acts mainly on histamine H1-receptors, stimulated all the penile strips tested. 4-Methylhistamine, which acts predominantly on H2-receptors... | Effects of histamine on the human penis muscle in vitro. Histamine produced three types of effects on corpus cavernosa muscle of the human penis: contraction, relaxation or a contraction followed by a relaxation. 2-Methylhistamine, which acts mainly on histamine H1-receptors, stimulated all the penile strips tested. 4-... | [
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PMID:21800 | Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium. | The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three agents shifted calcium dose-force relationships parallel and to the right. D600 acted as a competitive antagonist of calcium, as a plot of log ... | Effect of diazoxide, verapamil and compound D600 on isoproterenol and calcium-mediated dose-response relationships in isolated rabbit atrium. The effect of diazoxide, verapamil and compound D600 on calcium and isoproterenol dose-response relationships was investigated in isolated rabbit atrial preparations. All three a... | [
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PMID:21801 | Haemodynamic and baroreceptor responses to beta-adrenoceptor blocking agents in rabbits with cardiopulmonary bypass. | Blood pressure and peripheral resistance were reduced, baroreceptor activity was enhanced after i.v. infusion of beta-adrenoceptor blocking agents in rabbits with intact circulation or with total cardiopulmonary bypass. The latter preparation allowed cardiac effects of the drugs to be excluded. In rabbits with an intac... | Haemodynamic and baroreceptor responses to beta-adrenoceptor blocking agents in rabbits with cardiopulmonary bypass. Blood pressure and peripheral resistance were reduced, baroreceptor activity was enhanced after i.v. infusion of beta-adrenoceptor blocking agents in rabbits with intact circulation or with total cardiop... | [
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PMID:21802 | Release of spasmogens from rat isolated lungs by tryptamines. | Tryptamine and 5-hydroxytryptamine (5-HT) infused through the pulmonary circulation of rat isolated lungs released a spasmogen resembling slow reacting substance of anaphylaxis which we have denoted SRS-T and a PGE-like activity. SRS-T was not extractable from Krebs solution by several organic solvents at neutral or ac... | Release of spasmogens from rat isolated lungs by tryptamines. Tryptamine and 5-hydroxytryptamine (5-HT) infused through the pulmonary circulation of rat isolated lungs released a spasmogen resembling slow reacting substance of anaphylaxis which we have denoted SRS-T and a PGE-like activity. SRS-T was not extractable fr... | [
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PMID:21803 | The mode of contractile action of palytoxin on vascular smooth muscle. | Experiments were designed to assess the mode of action of palytoxin (PTX), isolated from Palythoa tuberculosa, on mechanically denervated rabbit aortic strips. PTX induced a sustained contraction in the muscle dose dependently. The contraction was irreversible. In the depolarized aorta, PTX did not induce a contraction... | The mode of contractile action of palytoxin on vascular smooth muscle. Experiments were designed to assess the mode of action of palytoxin (PTX), isolated from Palythoa tuberculosa, on mechanically denervated rabbit aortic strips. PTX induced a sustained contraction in the muscle dose dependently. The contraction was i... | [
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PMID:21804 | Effects of palytoxin on the electrical activity of dog and rabbit heart. | Reversible effects of palytoxin, extracted from colonies of the soft coral Palythoa caribaeorum, are described. There is a decrease of both membrane resting potential and overshoot during activity. Rise time of the action potential is prolonged, while repolarization is shortened. The electrical events resemble those se... | Effects of palytoxin on the electrical activity of dog and rabbit heart. Reversible effects of palytoxin, extracted from colonies of the soft coral Palythoa caribaeorum, are described. There is a decrease of both membrane resting potential and overshoot during activity. Rise time of the action potential is prolonged, w... | [
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PMID:21805 | Peptido-aminobenzophenones--novel latentiated benzo-1,4-diazepines. | It has been shown that cleavage of the N-terminal L-amino acids of a novel series of dipeptide derivatives of 2-aminobenzophenones occurs readily in vivo to give benzo-1,4-diazepines. Such compounds may serve as useful pro-drug forms of minor tranquilizers such as Valium. | Peptido-aminobenzophenones--novel latentiated benzo-1,4-diazepines. It has been shown that cleavage of the N-terminal L-amino acids of a novel series of dipeptide derivatives of 2-aminobenzophenones occurs readily in vivo to give benzo-1,4-diazepines. Such compounds may serve as useful pro-drug forms of minor tranquili... | [
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PMID:21809 | [Pharmacologic peculiarities of natural and synthetic alpha-adrenomimetics]. | The mechanical response of the isolated rat vas deferens to four alpha-adrenomimetic substances has been studied. The four test substances were noradrenaline, octopamine, 2-phenylethylamine and 2-(1-naphthylmethyl)imidazoline (Privin). Examination of the cumulative dose/response curves showed both qualitative and quant... | [Pharmacologic peculiarities of natural and synthetic alpha-adrenomimetics]. The mechanical response of the isolated rat vas deferens to four alpha-adrenomimetic substances has been studied. The four test substances were noradrenaline, octopamine, 2-phenylethylamine and 2-(1-naphthylmethyl)imidazoline (Privin). Examina... | [
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PMID:21806 | [Comparison of an aceclidine tremor with arecoline and nicotine ones in rats of different ages]. | A comparative characterization of a tremor produced by aceclidine (0.5--200 mg/kg), arecoline (1--30 mg/kg) and nicotine (0.1--8 mg/kg) in rats of different age is given and the influence on the tremor of atropine sulphate (1--100 mg/kg) and scopolamine hydrobromide hydrobromide (2.5 mg/kg) described. The common charac... | [Comparison of an aceclidine tremor with arecoline and nicotine ones in rats of different ages]. A comparative characterization of a tremor produced by aceclidine (0.5--200 mg/kg), arecoline (1--30 mg/kg) and nicotine (0.1--8 mg/kg) in rats of different age is given and the influence on the tremor of atropine sulphate ... | [
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PMID:21807 | [Mechanism of the cardiotoxic action of No-Spa]. | Tests set up in vivo on rats and with an isolated spontaneously contracting atrium of the cat brought evidence that nospanum produces an adverse chronotropic action, caused by a direct effect on the cardiac pacemaker. In the rat's myocardium the drug raised the pyruvate level, increased the lactate-dehydrogenase activi... | [Mechanism of the cardiotoxic action of No-Spa]. Tests set up in vivo on rats and with an isolated spontaneously contracting atrium of the cat brought evidence that nospanum produces an adverse chronotropic action, caused by a direct effect on the cardiac pacemaker. In the rat's myocardium the drug raised the pyruvate ... | [
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PMID:21808 | [Effect of pharmacological agents on the development of experimental brain edema]. | The effect of some neuroleptics, adreno-, sympatho- and cholinolytic substances on the development of "traumatic" and "mono-iodoacetate" brain edemas was studied in tests with rats. It was established that the neuroleptic chlorpromazine, the alpha-adreno-blocking agents phentolamine and dopegit and also the central M-c... | [Effect of pharmacological agents on the development of experimental brain edema]. The effect of some neuroleptics, adreno-, sympatho- and cholinolytic substances on the development of "traumatic" and "mono-iodoacetate" brain edemas was studied in tests with rats. It was established that the neuroleptic chlorpromazine,... | [
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PMID:21826 | Dissociation between cortisol-induced pycnosis and inhibition of [3H]uridine incorporation in rat thymocytes. | Treatment of rat thymocytes with cortisol induced an inhibition of [3H]uridine incorporation after 30-90 min, an accumulation of pycnotic cells after 90 min, and a decrease in cell viability after several hours. No cortisol-resistant cells could be distinguished, and dose-response curves for a number of glucocorticoids... | Dissociation between cortisol-induced pycnosis and inhibition of [3H]uridine incorporation in rat thymocytes. Treatment of rat thymocytes with cortisol induced an inhibition of [3H]uridine incorporation after 30-90 min, an accumulation of pycnotic cells after 90 min, and a decrease in cell viability after several hours... | [
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PMID:21829 | Estimation of serum acid proteases at pH 1.8 and pH 3.5 in patients with duodenal ulcer, gastric ulcer and gastric carcinoma. | Using a simple hemoglobin method on the basis of Anson-Mirsky's method, acid protease levels in serum were measured at pH 1.8 (pepsin) and pH 3.5 (gastricsin) in 18 healthy controls and 14 patients with duodenal ulcer, 19 patients with gastric ulcer and 18 patients with gastric cancer. Though acid protease activity in ... | Estimation of serum acid proteases at pH 1.8 and pH 3.5 in patients with duodenal ulcer, gastric ulcer and gastric carcinoma. Using a simple hemoglobin method on the basis of Anson-Mirsky's method, acid protease levels in serum were measured at pH 1.8 (pepsin) and pH 3.5 (gastricsin) in 18 healthy controls and 14 patie... | [
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PMID:21830 | Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage. | In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to relatively minor increases in hydrogen ion concentration. All studies became abnormal at pH 6.8. At pH 6.4, assays of the intrinsic and extr... | Effect of acid and pepsin on blood coagulation and platelet aggregation. A possible contributor prolonged gastroduodenal mucosal hemorrhage. In a series of in vitro studies, both the soluble (plasmatic) coagulation system and the cellular (platelet-mediated) aspect of coagulation were shown to be extremely sensitive to... | [
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PMID:21832 | A genetic and biochemical analysis of the temperature sensitive, normal-winged alleles of the rudimentary locus of Drosophila melanogaster. | The genetic and biochemical characteristics of a particular class of mutants at the rudimentary locus are described. The mutants are pyrimidine auxotrophs, like classical rudimentary alleles, but they are unique in that they do not alter the size or shape of the wing (Falk and Nash 1974b). Aspartate transcarbamylase an... | A genetic and biochemical analysis of the temperature sensitive, normal-winged alleles of the rudimentary locus of Drosophila melanogaster. The genetic and biochemical characteristics of a particular class of mutants at the rudimentary locus are described. The mutants are pyrimidine auxotrophs, like classical rudimenta... | [
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PMID:21834 | [Anti-inflammatory activity of benzo(c) phenanthridine derivatives and possible mechanisms of action (author's transl)]. | Of five newly synthesized benzo[c]phenanthridine derivatives tested, the two compounds, BPD-I and BPD-II were found to have potent anti-edematous activity with intraperitoneal administration to S.D. rats. BPD-I showed a marked inhibitory effect against acute inflammation such as induced rat paw edema and leucocyte emig... | [Anti-inflammatory activity of benzo(c) phenanthridine derivatives and possible mechanisms of action (author's transl)]. Of five newly synthesized benzo[c]phenanthridine derivatives tested, the two compounds, BPD-I and BPD-II were found to have potent anti-edematous activity with intraperitoneal administration to S.D. ... | [
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PMID:21835 | [Biochemical studies of acebutolol-the beta1 specificity of acebutolol (author's transl)]. | Effects of acebutolol on carbohydrate and lipid metabolism in rats and on adenylate cyclase of heart and liver in dogs were investigated to determine the beta receptor blocking properties of the compound. Acebutolol exhibited the beta blocking activity and inhibited the increase of serum lactate concentration induced b... | [Biochemical studies of acebutolol-the beta1 specificity of acebutolol (author's transl)]. Effects of acebutolol on carbohydrate and lipid metabolism in rats and on adenylate cyclase of heart and liver in dogs were investigated to determine the beta receptor blocking properties of the compound. Acebutolol exhibited the... | [
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PMID:21836 | [Effect of menstrual hygiene (tampons vs pads) and of the form of contraception on pH and bacterial infection of the vagina]. | In menstrual hygiene vaginal tampons are preferred. Supposedly intravaginal application causes discharge. Healthy women using pads as well as tampons were examined before, during, and after menstruation. During two menstrual cycles vaginal pH was measured, bacteriological and mycological cultures were set up. The resul... | [Effect of menstrual hygiene (tampons vs pads) and of the form of contraception on pH and bacterial infection of the vagina]. In menstrual hygiene vaginal tampons are preferred. Supposedly intravaginal application causes discharge. Healthy women using pads as well as tampons were examined before, during, and after mens... | [
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PMID:21837 | [Length of effectiveness of calcium-containing and calcium-free antacids. A double-blind study]. | The effect of a Ca-containing and Ca-free antacid on meal-stimulated acid secretion was examined by intragastric titration with pH being measured extragastrically. The Ca-containing antacid was more effective in neutralisation of the intragastric content (pH greater than 5,8) and increasing the pH (p less than 0,002). ... | [Length of effectiveness of calcium-containing and calcium-free antacids. A double-blind study]. The effect of a Ca-containing and Ca-free antacid on meal-stimulated acid secretion was examined by intragastric titration with pH being measured extragastrically. The Ca-containing antacid was more effective in neutralisat... | [
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PMID:21840 | Liver enzyme adaptation after lithium administration in handled and nonhandled rats. | We have examined the interaction of lithium administration and the infant stimulation procedure of handling on hormonally regulated enzymes of liver. Animals handled in infancy show an increased morning corticosterone level in response to lithium feeding and markedly elevated serum glucose during refeeding following a ... | Liver enzyme adaptation after lithium administration in handled and nonhandled rats. We have examined the interaction of lithium administration and the infant stimulation procedure of handling on hormonally regulated enzymes of liver. Animals handled in infancy show an increased morning corticosterone level in response... | [
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PMID:21842 | Conformational changes induced by ionic strength and pH in two bovine myelin basic proteins. | The structures of two biologically different myelin proteins, A1 from the central nervous system and P2 from the peripheral nervous system, were investigated. Both proteins were isolated from nerve tissues. Conformational changes in the homogeneous proteins were examined in aqueous solutions by means of circular dichro... | Conformational changes induced by ionic strength and pH in two bovine myelin basic proteins. The structures of two biologically different myelin proteins, A1 from the central nervous system and P2 from the peripheral nervous system, were investigated. Both proteins were isolated from nerve tissues. Conformational chang... | [
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PMID:21843 | Amino acid sequence of toxin III from Anemonia sulcata. | Toxin III, the smallest toxin component of the poison of the sea anemone Anemonia sulcata, is a polypeptide with 27 amino acids. Its structure is stabilized by three disulfide bridges. The amino acid sequence was determined by solid-phase Edman degradation of the aminoethylated derivative. The peptide was coupled to th... | Amino acid sequence of toxin III from Anemonia sulcata. Toxin III, the smallest toxin component of the poison of the sea anemone Anemonia sulcata, is a polypeptide with 27 amino acids. Its structure is stabilized by three disulfide bridges. The amino acid sequence was determined by solid-phase Edman degradation of the ... | [
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PMID:21844 | Hemocyanins in spiders, IV[1]. Subunit heterogeneity of Eurypelma (Dugesiella) hemocyanin, and separation of polypeptide chains. | The hemocyanin of the North American tarantula Eurypelma californicum (Dugesiella californica) is dissociated at pH 9.6 into monomers (Mr about 70 000) and dimers (Mr about 140 000), which were separated by gel filtration. The monomer peak was resolved by preparative polyacrylamide gel electrophoresis and yielded 4 pro... | Hemocyanins in spiders, IV[1]. Subunit heterogeneity of Eurypelma (Dugesiella) hemocyanin, and separation of polypeptide chains. The hemocyanin of the North American tarantula Eurypelma californicum (Dugesiella californica) is dissociated at pH 9.6 into monomers (Mr about 70 000) and dimers (Mr about 140 000), which we... | [
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0.0... |
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