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PMID:25417 | Sequence analysis of 5'[32P] labeled mRNA and tRNA using polyacrylamide gel electrophoresis. | Sequence analysis of 5'-[32P] labeled tRNA and eukaryotic mRNA using an adaptation of a method recently described by Donis-Keller, Maxam and Gilbert for mapping guanines, adenines and pyrimidines from the 5'-end of an RNA is described. In addition, a technique utilizing two-dimensional polyacrylamide gel electrophoresi... | Sequence analysis of 5'[32P] labeled mRNA and tRNA using polyacrylamide gel electrophoresis. Sequence analysis of 5'-[32P] labeled tRNA and eukaryotic mRNA using an adaptation of a method recently described by Donis-Keller, Maxam and Gilbert for mapping guanines, adenines and pyrimidines from the 5'-end of an RNA is de... | [
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PMID:25418 | Poly(dG).poly(dC) at neutral and alkaline pH: the formation of triple stranded poly(dG).poly(dG).poly(dC). | Alkaline titrations of different samples of poly(dG).poly(dC) and of the constituent homopolymers poly(dG) and poly(dC) have been performed in 0.15 M NaCl and their CD spectra followed. Sample I contained a slight excess of poly(dC) (52% C: 48% G) and showed a single reversible transition (pK = 11.9) due to the dissoci... | Poly(dG).poly(dC) at neutral and alkaline pH: the formation of triple stranded poly(dG).poly(dG).poly(dC). Alkaline titrations of different samples of poly(dG).poly(dC) and of the constituent homopolymers poly(dG) and poly(dC) have been performed in 0.15 M NaCl and their CD spectra followed. Sample I contained a slight... | [
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PMID:25419 | Base specific fractionation of double stranded DNA: affinity chromatography on a novel type of adsorbant. | A material suitable for base-pair-specific "affinity chromatography" of double stranded DNA is described. The synthesis of this material involves two successive polymerization reactions yielding solid particles of cross-linked bisacrylamide to which base-pair-specific dyes are covalently attached by spacers of polyacry... | Base specific fractionation of double stranded DNA: affinity chromatography on a novel type of adsorbant. A material suitable for base-pair-specific "affinity chromatography" of double stranded DNA is described. The synthesis of this material involves two successive polymerization reactions yielding solid particles of ... | [
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PMID:25420 | New observations concerning the chloroacetaldehyde reaction with some tRNA constituents. Stable intermediates, kinetics and selectivity of the reaction. | The stable intermediates formed in the reaction of cytosine, cytidine and adenosine with chloracetaldehyde were isolated. The -CH2CH/OH/- bridge between the exo and endo nitrogen atoms of the parent base was found in these compounds by means of PMR spectroscopy. Their acid-induced dehydration resulted in formation of a... | New observations concerning the chloroacetaldehyde reaction with some tRNA constituents. Stable intermediates, kinetics and selectivity of the reaction. The stable intermediates formed in the reaction of cytosine, cytidine and adenosine with chloracetaldehyde were isolated. The -CH2CH/OH/- bridge between the exo and en... | [
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PMID:25421 | Evidence that proteins S1, S11 and S21 directly participates in the binding of transfer RNA to the 30S ribosome. | In a previous publication1 we reported that the tyrosine selective reagent, tetraitromethane, causes complete inactivation of E. coli 30S ribosomes for poly U directed non-enzymatic phe-tRNA binding. This inactivation was demonstrated to be due to the chemical modification of the protein moiety of the ribosome. We have... | Evidence that proteins S1, S11 and S21 directly participates in the binding of transfer RNA to the 30S ribosome. In a previous publication1 we reported that the tyrosine selective reagent, tetraitromethane, causes complete inactivation of E. coli 30S ribosomes for poly U directed non-enzymatic phe-tRNA binding. This in... | [
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PMID:25424 | Physico-chemical investigation of AlPO4 for the manufacture of antacids. I. Effect of precipitation and processing conditions on physico-chemical properties of AlPO4. | Aluminium phosphate was precipitated from AlCl3-H3PO4 and NaOH, NH3H2O and NaHCO3--Na2CO3 mixture up to different pH values. The precipitates were dried at room temperature, 40 degrees and 105 degrees and their neutralizing properties (rate of neutralization and acid-consuming capacity) against 0.l N HCl were investiga... | Physico-chemical investigation of AlPO4 for the manufacture of antacids. I. Effect of precipitation and processing conditions on physico-chemical properties of AlPO4. Aluminium phosphate was precipitated from AlCl3-H3PO4 and NaOH, NH3H2O and NaHCO3--Na2CO3 mixture up to different pH values. The precipitates were dried ... | [
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PMID:25427 | [Mendelson's syndrome]. | Mendelson's syndrome is discussed with a review of the literature and presentation of 27 personal cases studies. Accidental aspiration of gastric fluid occurs primarily during anesthesia, in cranial trauma victims, and in toxic coma patients. Tissue damage is proportional to the acidity and the quantity of aspirated fl... | [Mendelson's syndrome]. Mendelson's syndrome is discussed with a review of the literature and presentation of 27 personal cases studies. Accidental aspiration of gastric fluid occurs primarily during anesthesia, in cranial trauma victims, and in toxic coma patients. Tissue damage is proportional to the acidity and the ... | [
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PMID:25425 | Choline acetyltransferase and acetylcholinesterase activities in mice brain during the antagonistic action of antidepressant drugs and Ro 4--1284. | Choline acetyltransferase (Ach-T) and acetylcholinesterase (Ach-E) activities in mice brain during the reverse action by imipramine, pheniprazine and pargyline to the syndrome elicited by intraperitoneal administration of Ro 4--1284 were investigated. A single dose of imipramine did not reverse reserpine-like syndrome ... | Choline acetyltransferase and acetylcholinesterase activities in mice brain during the antagonistic action of antidepressant drugs and Ro 4--1284. Choline acetyltransferase (Ach-T) and acetylcholinesterase (Ach-E) activities in mice brain during the reverse action by imipramine, pheniprazine and pargyline to the syndro... | [
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PMID:25426 | Central action of narcotic analgesics. II. Locomotor activity and narcotic analgesics. | The effect of morphine, codeine, fentanyl and pentazocine on locomotor activity of rats and mice and open-field performance of rats were tested. All the analgesics tested produced a depressive action in the rat. In mice a depressive action was produced by pentazocine and codeine. Fentanyl increased the exploratory and ... | Central action of narcotic analgesics. II. Locomotor activity and narcotic analgesics. The effect of morphine, codeine, fentanyl and pentazocine on locomotor activity of rats and mice and open-field performance of rats were tested. All the analgesics tested produced a depressive action in the rat. In mice a depressive ... | [
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PMID:25429 | [Preventive action of catecholamine and serotonin synthesis inhibitors and of adrenergic blockaders on the occurrence of the anovular syndrome in neonatally androgenized rats. I]. | Administration of catecholamine synthesis inhibitors (alpha-methl-p-tyrosine) or serotonin (parachlorphenylalanine) simultaneously with testosterone propionate prevented the anovular sterility in the majority of the neonatally androgenized rats. Preventive action of adrenoblockers (droperidol and propranolol) on the ef... | [Preventive action of catecholamine and serotonin synthesis inhibitors and of adrenergic blockaders on the occurrence of the anovular syndrome in neonatally androgenized rats. I]. Administration of catecholamine synthesis inhibitors (alpha-methl-p-tyrosine) or serotonin (parachlorphenylalanine) simultaneously with test... | [
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PMID:25436 | Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides. | Mitochondria from normal rat liver and heart, and also Ehrlich tumor cells, respiring on succinate as energy source in the presence of rotenone (to prevent net electron flow to oxygen from the endogenous pyridine nucleotides), rapidly take up Ca(2+) and retain it so long as the pyridine nucleotides are kept in the redu... | Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides. Mitochondria from normal rat liver and heart, and also Ehrlich tumor cells, respiring on succinate as energy source in the presence of rotenone (to prevent net electron flow to oxygen from the endogenous pyridine nucl... | [
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PMID:25437 | Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. | Two methyltransferases involved in the methylation of phosphatidylethanolamine to form phosphatidylcholine were demonstrated in a microsomal fraction of bovine adrenal medulla. The first methyltransferase catalyzes the methylation of phosphatidylethanolamine to form phosphatidyl-N-monomethylethanolamine. This enzyme ha... | Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. Two methyltransferases involved in the methylation of phosphatidylethanolamine to form phosphatidylcholine were demonstrated in a microsomal fraction of bovine adrenal medulla. The first methyltrans... | [
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PMID:25438 | Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue. | Highly purified fractions of gamma-glutamyl transpeptidase [gamma-glutamyltrinsferase; (5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2] from normal and malignant rat mammary tissue were prepared. Analyses by isoelectric focusing indicate the existence of at least 12 enzymatically active species. The g... | Differences in the isoelectric focusing patterns of gamma-glutamyl transpeptidase from normal and cancerous rat mammary tissue. Highly purified fractions of gamma-glutamyl transpeptidase [gamma-glutamyltrinsferase; (5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2] from normal and malignant rat mammary ... | [
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PMID:25439 | High-resolution 31P nuclear magnetic resonance study of rat liver mitochondria. | Intact mitochondria were studied by high-resolution 31P nuclear magnetic resonance. Observable internal phosphate compounds included inorganic phosphate (Pi), ADP, and ATP. The internal pH was determined by the chemical shift of the internal Pi, the pK2 (6.7) of which was measured in uncoupled mitochondria. The observe... | High-resolution 31P nuclear magnetic resonance study of rat liver mitochondria. Intact mitochondria were studied by high-resolution 31P nuclear magnetic resonance. Observable internal phosphate compounds included inorganic phosphate (Pi), ADP, and ATP. The internal pH was determined by the chemical shift of the interna... | [
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PMID:25440 | Differential desensitization of functional adrenergic receptors in normal and malignant myeloid cells: relationship to receptor-mediated hormone cytotoxicity. | Malignant myeloid leukemic cells and normal macrophages and granulocytes have functional beta-adrenergic receptors, which have been quantitated by radioreceptor binding with the beta-adrenergic antagonist [(3)H]dihydroalprenolol and by induction of cyclic AMP by adrenergic hormones. Both the normal and leukemic cells h... | Differential desensitization of functional adrenergic receptors in normal and malignant myeloid cells: relationship to receptor-mediated hormone cytotoxicity. Malignant myeloid leukemic cells and normal macrophages and granulocytes have functional beta-adrenergic receptors, which have been quantitated by radioreceptor ... | [
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PMID:25441 | Functional properties of beta-galactosidase from mutant strain 13 PO of Escherichia coli. | The functional properties of CZP protein, a mutant deriving from wild-type beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) by a point mutation, were investigated. A large decrease of the specificity, as evaluated by the kcat/Km ratio, was observed, principally originated by a weaker binding of the... | Functional properties of beta-galactosidase from mutant strain 13 PO of Escherichia coli. The functional properties of CZP protein, a mutant deriving from wild-type beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23) by a point mutation, were investigated. A large decrease of the specificity, as evalu... | [
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PMID:25442 | Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation. | Stereotaxic injection of kainic acid into the striatum of adult rats causes degeneration of neurons intrinsic to the striatum but spares axons of passage and of termination of extrinsic neurons. Neurochemical and histologic studies demonstrate that striatal neurons are almost insensitive to kainate at 7 days after birt... | Ontogenetic development of kainate neurotoxicity: correlates with glutamatergic innervation. Stereotaxic injection of kainic acid into the striatum of adult rats causes degeneration of neurons intrinsic to the striatum but spares axons of passage and of termination of extrinsic neurons. Neurochemical and histologic stu... | [
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PMID:25444 | Evaluation of psychotropic drugs with a modified open field test. | The open field test used to study behavioral alterations induced by psychotropic drugs is based mainly in the defecation, ambulation, rearing and grooming presented by animals subjected to the test. Because of the criticisms raised against the defecation score as a measure of the central effects of drugs, in the presen... | Evaluation of psychotropic drugs with a modified open field test. The open field test used to study behavioral alterations induced by psychotropic drugs is based mainly in the defecation, ambulation, rearing and grooming presented by animals subjected to the test. Because of the criticisms raised against the defecation... | [
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PMID:25445 | Bromocriptine, lergotrile: the antiparkinsonian efficacy and the interaction with monoaminergic receptors. | The antiparkinsonian activity of bromocriptine and of lergotrile was investigated in monkeys with surgically induced tremor and in parkinsonian patients. Both drugs effectively relieve tremor in experimental monkeys and induce less pronounced abnormal involuntary movements than L-dopa or piribedil. Both drugs were show... | Bromocriptine, lergotrile: the antiparkinsonian efficacy and the interaction with monoaminergic receptors. The antiparkinsonian activity of bromocriptine and of lergotrile was investigated in monkeys with surgically induced tremor and in parkinsonian patients. Both drugs effectively relieve tremor in experimental monke... | [
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PMID:25448 | Blood pressure response to bolus administration of vasoactive drugs in the rat. | The time course of systemic blood pressure response in normotensive anaesthetized rats was studied after a bolus administration of standard doses (0.4 microgram/kg) of noradrenaline, adrenaline, isoprenaline, acetylcholine, serotonin, bradykinin, and histamine. The single stimulus of a vasoactive agent elicits a blood ... | Blood pressure response to bolus administration of vasoactive drugs in the rat. The time course of systemic blood pressure response in normotensive anaesthetized rats was studied after a bolus administration of standard doses (0.4 microgram/kg) of noradrenaline, adrenaline, isoprenaline, acetylcholine, serotonin, brady... | [
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PMID:25449 | Skin rejection in graft-versus-host disease. | Graft-versus-host disease is becoming a common clinical problem, one which can require the consultation of a plastic surgeon for restoration of skin coverage. An understanding of the immunological basis of the disease is essential to the clinical management of this condition. A case of GVHD is reported, and the princip... | Skin rejection in graft-versus-host disease. Graft-versus-host disease is becoming a common clinical problem, one which can require the consultation of a plastic surgeon for restoration of skin coverage. An understanding of the immunological basis of the disease is essential to the clinical management of this condition... | [
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PMID:25454 | The effect of chronic lithium administration on dopamine metabolism in rat striatum. | Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentration after 3 weeks of lithium administration. There was no change in tyrosine hydroxylas... | The effect of chronic lithium administration on dopamine metabolism in rat striatum. Striatal dopamine and its metabolites were studied in rats given lithium chloride in the diet. Results showed an increase in homovanillic acid and 3,4-dihydroxyphenylacetic acid levels but no significant change in dopamine concentratio... | [
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PMID:25455 | Prolactin secretion during and after Noveril infusions to depressive patients. | Dibenzapine (720 mg, Noveril) was infused intravenously to 16 depressed patients during a period of 3 h. Serum prolactin levels were determined by radioimmunoassay and changes in clinical condition were evaluated according to the Hamilton Equation. The two variables were correlated to each other. In most of the patient... | Prolactin secretion during and after Noveril infusions to depressive patients. Dibenzapine (720 mg, Noveril) was infused intravenously to 16 depressed patients during a period of 3 h. Serum prolactin levels were determined by radioimmunoassay and changes in clinical condition were evaluated according to the Hamilton Eq... | [
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PMID:25463 | The degradation of a nonapeptide, sleep inducing peptide, in rat brain: comparison with enkephalin breakdown. | The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates. After 7.5 minutes of incubation of 2.5% (w/v) homogenate, 30% of N-terminal tryptophan was released from DSIP, while 75% of N-terminal tyrosine was released from Metenkephalin. The optimal p... | The degradation of a nonapeptide, sleep inducing peptide, in rat brain: comparison with enkephalin breakdown. The degradation of delta sleep inducing peptide (DSIP) was studied and compared with that of Met-enkephalin in brain homogenates. After 7.5 minutes of incubation of 2.5% (w/v) homogenate, 30% of N-terminal tryp... | [
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PMID:25464 | In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin. | The influence of hydroxyphentoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-l... | In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin. The influence of hydroxyphentoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicoti... | [
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PMID:25465 | [The effect of mainly alpha-adrenergic drugs, indirect sympathomimetrics and dopamine on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)]. | The influence of mainly alpha-adrenergic drugs (noradrenaline, adrenaline, phenylephrine), indirect sympathomimetics (ephedrine, tyramin) and dopamine on the exocrine pancreatic function of the isolated perfused organ of cats was studied. The injection of noradrenaline and adrenaline induced simultaneously a rapid depr... | [The effect of mainly alpha-adrenergic drugs, indirect sympathomimetrics and dopamine on exocrine pancreatic function. Studies in the isolated cat pancreas (author's transl)]. The influence of mainly alpha-adrenergic drugs (noradrenaline, adrenaline, phenylephrine), indirect sympathomimetics (ephedrine, tyramin) and do... | [
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PMID:25466 | A comparison of rimiterol and salbutamol by inhalation at high and low dose in asthmatic patients. | Rimiterol hydrobromide (Pulmadil) has been shown to have a dose-related bronchodilator effect; the optimum dose by inhalation appears to lie between 200 and 1,000 microgram. When given to a group of asthmatic patients at 'recommended' and 5--10 times 'recommended' dose by aerosol, cardiovascular effects were minimal an... | A comparison of rimiterol and salbutamol by inhalation at high and low dose in asthmatic patients. Rimiterol hydrobromide (Pulmadil) has been shown to have a dose-related bronchodilator effect; the optimum dose by inhalation appears to lie between 200 and 1,000 microgram. When given to a group of asthmatic patients at ... | [
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PMID:25467 | A brief review of sympathomimetic bronchodilators and a description of a new selective agent, rimiterol hydrobromide. | The development of beta2-specific sympathomimetic bronchodilators (rimiterol, salbutamol, terbutaline) has made the basic treatment of asthmatic patients more safe and effective. Despite that, the asthmatics should be under careful control and all patients should be taught the correct way to use their bronchodilator ae... | A brief review of sympathomimetic bronchodilators and a description of a new selective agent, rimiterol hydrobromide. The development of beta2-specific sympathomimetic bronchodilators (rimiterol, salbutamol, terbutaline) has made the basic treatment of asthmatic patients more safe and effective. Despite that, the asthm... | [
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PMID:25469 | The effect of dibutyryl cyclic AMP and glucagon on the myocardial cell pH1. | DBcAMP or crystalline glucagon was utilized to elevate the intracellular cyclic AMP concentration in isolated rat hearts. Butyric acid, a metabolite of DBcAMP, was also investigated. Their effect on the intracellular pH (pHi) as determined by the distribution of [14C]DMO was investigated. Rat hearts, perfused with a re... | The effect of dibutyryl cyclic AMP and glucagon on the myocardial cell pH1. DBcAMP or crystalline glucagon was utilized to elevate the intracellular cyclic AMP concentration in isolated rat hearts. Butyric acid, a metabolite of DBcAMP, was also investigated. Their effect on the intracellular pH (pHi) as determined by t... | [
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PMID:25486 | Behavioral neurochemistry: neuroregulators and behavioral states. | There is compelling evidence that behavioral events after neurochemical function and that altered neurochemical function can change behavior. Such processes have been related both to neurotransmitters and to neuromodulators, together termed neuroregulators. Available research tools and theoretical constructs have begun... | Behavioral neurochemistry: neuroregulators and behavioral states. There is compelling evidence that behavioral events after neurochemical function and that altered neurochemical function can change behavior. Such processes have been related both to neurotransmitters and to neuromodulators, together termed neuroregulato... | [
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PMID:25487 | Medical treatment of mental illness. | Psychotherapeutic drugs have dramatically improved the prognosis for patients with severe mental illness. The drug treatments are not a panacea. The medications sometimes cause irreversible side effects, and they are not helpful for all patients. They allow large numbers of individuals to leave the hospital, but to ret... | Medical treatment of mental illness. Psychotherapeutic drugs have dramatically improved the prognosis for patients with severe mental illness. The drug treatments are not a panacea. The medications sometimes cause irreversible side effects, and they are not helpful for all patients. They allow large numbers of individu... | [
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PMID:25488 | Somatostatin--paracrine and neuromodulator peptide in gut and nervous system. | Somatostatin, a tetradecapeptide widely distributed in nervous tissue and gut, has inhibitory effects on secretion and neuromuscular activity. The actions of this peptide probably embrace three types of transmitter-receptor interaction, namely that of a neurotransmitter in the nervous system, that of a hormone in the h... | Somatostatin--paracrine and neuromodulator peptide in gut and nervous system. Somatostatin, a tetradecapeptide widely distributed in nervous tissue and gut, has inhibitory effects on secretion and neuromuscular activity. The actions of this peptide probably embrace three types of transmitter-receptor interaction, namel... | [
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PMID:25489 | Comparison of cardiovascular responses and left ventricular work during exercise before and after artificial heart implantation. | Cardiovascular dynamics and left ventricular work were evaluated in 15 resting, standing, and treadmill-exercised calves before and at periodic intervals after their natural hearts (NH) were replaced with an artificial heart (AH). Standing produced increases in heart rate, cardiac output, oxygen uptake, and left ventri... | Comparison of cardiovascular responses and left ventricular work during exercise before and after artificial heart implantation. Cardiovascular dynamics and left ventricular work were evaluated in 15 resting, standing, and treadmill-exercised calves before and at periodic intervals after their natural hearts (NH) were ... | [
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PMID:25495 | Endocrine-like cells in the terminal bronchioles and saccules of human fetal lung: an ultrastructural study. | An ultrastructural study of Kulschitsky cells was made on lung tissue from five human fetuses of gestational ages between 18 and 25 weeks. The cells were found to occur with relative frequency throughout the bronchi and bronchioles, as well as in the developing saccules. This report describes in detail the cells of the... | Endocrine-like cells in the terminal bronchioles and saccules of human fetal lung: an ultrastructural study. An ultrastructural study of Kulschitsky cells was made on lung tissue from five human fetuses of gestational ages between 18 and 25 weeks. The cells were found to occur with relative frequency throughout the bro... | [
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PMID:25497 | Anchoring cells (Desmocytes) in the hydrozoan polyp Cordylophora. | Desmocytes or anchoring cells are present on the upright stolons of the athecate hydroid Cordylophora caspia and function to support the soft coenosarc within the rigid tube of perisarc by linking the perisarc with the mesoglea. These cells are characterized by accumulations of 70 A filaments which aggregate into dense... | Anchoring cells (Desmocytes) in the hydrozoan polyp Cordylophora. Desmocytes or anchoring cells are present on the upright stolons of the athecate hydroid Cordylophora caspia and function to support the soft coenosarc within the rigid tube of perisarc by linking the perisarc with the mesoglea. These cells are character... | [
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PMID:25503 | Testicular descent. Normal and abnormal. | The subject of testicular descent has been reviewed. An attempt has been made to present a basic understanding of the embryology and mechanisms of this event. The abnormalities of testicular descent have also been discussed, including the pathogenesis and complications of this disorder, which is the most common develop... | Testicular descent. Normal and abnormal. The subject of testicular descent has been reviewed. An attempt has been made to present a basic understanding of the embryology and mechanisms of this event. The abnormalities of testicular descent have also been discussed, including the pathogenesis and complications of this d... | [
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PMID:25500 | Storage of platelets prepared by discontinuous flow centrifugation. | Platelet concentrates were prepared by plateletpheresis using discontinuous flow centrifugation. Platelet units were stored in PL-146 bags of 300 ml and 2,000 ml capacity, and in vitro measures helpful in predicting platelet viability were compared. Storage in bags of 300 ml capacity led to significant fall in pH, decr... | Storage of platelets prepared by discontinuous flow centrifugation. Platelet concentrates were prepared by plateletpheresis using discontinuous flow centrifugation. Platelet units were stored in PL-146 bags of 300 ml and 2,000 ml capacity, and in vitro measures helpful in predicting platelet viability were compared. St... | [
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PMID:25506 | The influence of pH on antimicrobial substances in canine vaginal and urethral secretions. | Trimethoprim and rosamicin (a new basic macrolide antibiotic) were administered to normal and oophorectomised female dogs by constant intravenous infusion before and after oestrogen and androgen administration. Their concentrations in plasma and in urethral and vaginal secretions were determined by bioassay and correla... | The influence of pH on antimicrobial substances in canine vaginal and urethral secretions. Trimethoprim and rosamicin (a new basic macrolide antibiotic) were administered to normal and oophorectomised female dogs by constant intravenous infusion before and after oestrogen and androgen administration. Their concentratio... | [
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PMID:25507 | Milk fever prevention. | Milk fever is a disease of increasing importance. In dairy herds its incidence has doubled since 1950; today about 8 per cent of parturitions in Swedish dairy cattle are complicated by milk fever. At the same time, the clinical picture has changed and the effectiveness of calcium therapy has been markedly reduced. Thir... | Milk fever prevention. Milk fever is a disease of increasing importance. In dairy herds its incidence has doubled since 1950; today about 8 per cent of parturitions in Swedish dairy cattle are complicated by milk fever. At the same time, the clinical picture has changed and the effectiveness of calcium therapy has been... | [
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PMID:25509 | Glutathione conjugation and mercapturic acid formation in the developing rat, in vivo and in vitro. | 1. The levels of GSH-S-epoxidetransferase (GSH-S-transferase E, EC 2.5.1.18), gamma-glutamyl transpeptidase (EC 2.3.2.2) and S-substituted cysteine N-acetyltransferase have been measured in the liver and kidney of neonatal to adult rats. 2. GSH-S-epoxidetransferase and S-substituted cysteine N-acetyltransferase activit... | Glutathione conjugation and mercapturic acid formation in the developing rat, in vivo and in vitro. 1. The levels of GSH-S-epoxidetransferase (GSH-S-transferase E, EC 2.5.1.18), gamma-glutamyl transpeptidase (EC 2.3.2.2) and S-substituted cysteine N-acetyltransferase have been measured in the liver and kidney of neonat... | [
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PMID:25516 | [Characteristics of pancreatic basal secretion in the dog]. | A method is described for the simultaneous evaluation of the pancreatic, the biliary and the gastric secretion in long-term experiments. Under these conditions, the pancreatic basal secretion is characterized. The pancreatic basal secretion is a very variable reference value that is influenced by endogenous stimuli. Th... | [Characteristics of pancreatic basal secretion in the dog]. A method is described for the simultaneous evaluation of the pancreatic, the biliary and the gastric secretion in long-term experiments. Under these conditions, the pancreatic basal secretion is characterized. The pancreatic basal secretion is a very variable ... | [
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PMID:25544 | [Animal experiment studies on the neurohumoral control of female puberty]. | To study the mode of action of oestrogen in female sexual maturation, prepubertal female rats were treated in different ways with oestradiol benzoate (OB). Using an improved implantation method, former findings on a hypophysial site of oestrogen action in the positive feedback (Hohlweg effect) were confirmed. A single ... | [Animal experiment studies on the neurohumoral control of female puberty]. To study the mode of action of oestrogen in female sexual maturation, prepubertal female rats were treated in different ways with oestradiol benzoate (OB). Using an improved implantation method, former findings on a hypophysial site of oestrogen... | [
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PMID:25546 | [Relationship between the pathogenesis of lumbosacral radiculitis and specific treatment]. | On the basis of personal experience in treating 534 patients with sacro-lumbar radiculitis the authors believe it expedient to distinguish the following clinical syndromes: lumbago, radicle neuralgia, radicle neuritis, radicle neuritis with a paralysis of the foot and the caudal syndrome. In their opinion, the main pat... | [Relationship between the pathogenesis of lumbosacral radiculitis and specific treatment]. On the basis of personal experience in treating 534 patients with sacro-lumbar radiculitis the authors believe it expedient to distinguish the following clinical syndromes: lumbago, radicle neuralgia, radicle neuritis, radicle ne... | [
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PMID:25547 | [Diffuse x-ray wide-angle scattering of polyglutamic acid in solution]. | The diffuse wide angle x-ray scattering (WAXS) of polyglutamic acid (PGA) in solution was studied using an x-ray diffractometer with small aperture of the primary beam. The scattering curve was recorded at an angular interval from (article: see text). The experimental scattering intensity of PGA with alpha-helical CD ... | [Diffuse x-ray wide-angle scattering of polyglutamic acid in solution]. The diffuse wide angle x-ray scattering (WAXS) of polyglutamic acid (PGA) in solution was studied using an x-ray diffractometer with small aperture of the primary beam. The scattering curve was recorded at an angular interval from (article: see te... | [
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PMID:25548 | Substrate binding to solubilized cytochrome P-450 from rabbits at different temperatures. | The binding affinities of selected type I- and type II-substrates to partially purified cytochrome p-450 from rabbit liver microsomes were studied and found to differ from those of rats. The temperature dependence of the apparent binding constants qualitatively exhibited the same characteristics compared with that of r... | Substrate binding to solubilized cytochrome P-450 from rabbits at different temperatures. The binding affinities of selected type I- and type II-substrates to partially purified cytochrome p-450 from rabbit liver microsomes were studied and found to differ from those of rats. The temperature dependence of the apparent ... | [
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PMID:25549 | The influence of NADH on the ethylmorphine-N-demethylation in liver microsomes from control and phenobarbital-treated rats or different ages. | The ethylmorphine-N-demethylation by liver microsomes from control and phenobarbital-treated rats of different ages was investigated by means of adding NADPH in combination with NADH to the incubation medium. The rate of ethylmorphine-N-demethylation in the presence of NADPH without NADH is greater in adult than in yo... | The influence of NADH on the ethylmorphine-N-demethylation in liver microsomes from control and phenobarbital-treated rats or different ages. The ethylmorphine-N-demethylation by liver microsomes from control and phenobarbital-treated rats of different ages was investigated by means of adding NADPH in combination with... | [
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PMID:25551 | Role of neurotransmitters, prostaglandins and glucose on precursor incorporation into the RNA of thyroid slices. | The present studies were performed in order to investigate the role of neurotransmitters, prostaglandins and glucose on [3H] uridine incorporation into total RNA in beef thyroid slices. Carbamylcholine strongly stimulated RNA labelling from [3H uridine; atropine abolished this effect. NaF, at 1 and 5 mM, progressively ... | Role of neurotransmitters, prostaglandins and glucose on precursor incorporation into the RNA of thyroid slices. The present studies were performed in order to investigate the role of neurotransmitters, prostaglandins and glucose on [3H] uridine incorporation into total RNA in beef thyroid slices. Carbamylcholine stron... | [
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PMID:25552 | Sympathetic amines, renin and blood pressure. | The sympathetic nervous system and the renin-angiotensin mechanism each can influence blood pressure separately but the two systems also interact functionally in various ways. There is good evidence that central catecholaminergic neurons play an essential role in the regulation of blood pressure but it may be assumed t... | Sympathetic amines, renin and blood pressure. The sympathetic nervous system and the renin-angiotensin mechanism each can influence blood pressure separately but the two systems also interact functionally in various ways. There is good evidence that central catecholaminergic neurons play an essential role in the regula... | [
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PMID:25553 | Cardiovascular actions of bromocriptine. | Bromocriptine lowers blood pressure in animals and in man. Results obtained in experiments performed in the dog and cat suggest three possible mechanisms of action: a) relaxation of vascular smooth muscle, principally in splanchnic and renal vessels, (b) inhibition of transmitter release from noradrenergic nerve ending... | Cardiovascular actions of bromocriptine. Bromocriptine lowers blood pressure in animals and in man. Results obtained in experiments performed in the dog and cat suggest three possible mechanisms of action: a) relaxation of vascular smooth muscle, principally in splanchnic and renal vessels, (b) inhibition of transmitte... | [
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PMID:25554 | Bone marrow transplantation between mixed leukocyte culture reactive siblings. | Bone marrow transplantation from an HLA identical MLC reactive sibling has been performed in a patient with acute myelogenous leukemia resistant to drug treatment. Prompt engraftment was documented; however, the patient died of septicemia 34 days after transplant. Clinical manifestation of graft vs. host reaction was m... | Bone marrow transplantation between mixed leukocyte culture reactive siblings. Bone marrow transplantation from an HLA identical MLC reactive sibling has been performed in a patient with acute myelogenous leukemia resistant to drug treatment. Prompt engraftment was documented; however, the patient died of septicemia 34... | [
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PMID:25555 | Salicylazosulphapyridine-induced Heinz body anemia. | A 58-year-old patient suffered from severe malabsorption due to agammaglobulinemia. Treated empirically with salicylazosulfapyridine 2--6 g/day, the subjective and objective features of malabsorption regressed. About a year after this treatment she developed a generalized weakness without renewal of the diarrhea; the d... | Salicylazosulphapyridine-induced Heinz body anemia. A 58-year-old patient suffered from severe malabsorption due to agammaglobulinemia. Treated empirically with salicylazosulfapyridine 2--6 g/day, the subjective and objective features of malabsorption regressed. About a year after this treatment she developed a general... | [
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PMID:25556 | Acid-base status during reconstructive surgery of the abdominal aorta. | Abolition of a temporary occlusion of the circulation in the legs during surgical reconstruction of the abdominal aorta generally exerts but little influence on the patient's acid-base status. The changes in acid-base status can be corrected by the patient himself. Routine administration of sodium bicarbonate or Tham i... | Acid-base status during reconstructive surgery of the abdominal aorta. Abolition of a temporary occlusion of the circulation in the legs during surgical reconstruction of the abdominal aorta generally exerts but little influence on the patient's acid-base status. The changes in acid-base status can be corrected by the ... | [
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PMID:25557 | The effect of prolonged experimental hypercapnia on the brain. | Thirteen adult rabbits were exposed to a breathing air mixture containing an increasing amount of CO2 for eight weeks. When the CO2 content reached 9 Vol% the animals became apathic and lost body weight. The EEG showed a reduction of the amplitudes of 1o Hz frequences. Blood gases revealed an increase of bicarbonate bu... | The effect of prolonged experimental hypercapnia on the brain. Thirteen adult rabbits were exposed to a breathing air mixture containing an increasing amount of CO2 for eight weeks. When the CO2 content reached 9 Vol% the animals became apathic and lost body weight. The EEG showed a reduction of the amplitudes of 1o Hz... | [
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PMID:25559 | Effect of lactate on FFA--release and cyclic 3', 5' AMP accumulation in fat cells at different pH. | Effect of lactate on FFA--release and cyclic 3', 5-AMP accumulation in fat cells at different pH. Acta Physiol. Pol., 1977, 28 (6): 505--510. The effect of sodium lactate on noradrenaline (NA), theophyline (Th), and dibutyryl cyclic 3', 5'AMP stimulated free fatty acid (FFA) release as well as on NA--stimulated cyclic ... | Effect of lactate on FFA--release and cyclic 3', 5' AMP accumulation in fat cells at different pH. Effect of lactate on FFA--release and cyclic 3', 5-AMP accumulation in fat cells at different pH. Acta Physiol. Pol., 1977, 28 (6): 505--510. The effect of sodium lactate on noradrenaline (NA), theophyline (Th), and dibut... | [
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PMID:25567 | Relationship between adrenergic blocking and antihypertensive effects of beta receptor antagonists. | In hypertensive patients, whose blood pressure was decreased by racemic propranololthe dextrorotatory isomer had no antihypertensive effect. The differences in antihypertensive activity of racemic and dextrorotatory propranolol cannot be explained by different plasma levels; the data indicate that the hypotensive effec... | Relationship between adrenergic blocking and antihypertensive effects of beta receptor antagonists. In hypertensive patients, whose blood pressure was decreased by racemic propranololthe dextrorotatory isomer had no antihypertensive effect. The differences in antihypertensive activity of racemic and dextrorotatory prop... | [
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PMID:25568 | The significance of beta1-beta2-selectivity and intrinsic sympathomimetic activity in beta-blockers, with particular reference to antihypertensive treatment. | From the findings described in the already fairly copious literature on antihypertensive therapy with beta-blockers, as well as on the basis of theoretical considerations, it may be concluded that neither cardio-selectivity nor intrinsic sympathomimetic activity is of decisive importance with regard to the blood-pressu... | The significance of beta1-beta2-selectivity and intrinsic sympathomimetic activity in beta-blockers, with particular reference to antihypertensive treatment. From the findings described in the already fairly copious literature on antihypertensive therapy with beta-blockers, as well as on the basis of theoretical consid... | [
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PMID:25574 | Neuropharmacology and aging. | This review has attempted to convey the idea that the current concepts of psychotropic drug actions are based largely around the monoamine transmitter systems. Several of the hypotheses which implicate abnormalities of these systems as factors involved in the aging brain are discussed. It is suggested that the current ... | Neuropharmacology and aging. This review has attempted to convey the idea that the current concepts of psychotropic drug actions are based largely around the monoamine transmitter systems. Several of the hypotheses which implicate abnormalities of these systems as factors involved in the aging brain are discussed. It i... | [
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PMID:25576 | Tardive dyskinesia. | The movement disorder may appear after prolonged use of antipsychotic agents. Differential diagnosis includes hereditary, infectious, toxic and drug-induced causes of extrapyramidal dysfunction. Pathophysiology appears to be related to induced changes in dopamine neuronal function and may represent irreversible extrapy... | Tardive dyskinesia. The movement disorder may appear after prolonged use of antipsychotic agents. Differential diagnosis includes hereditary, infectious, toxic and drug-induced causes of extrapyramidal dysfunction. Pathophysiology appears to be related to induced changes in dopamine neuronal function and may represent ... | [
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PMID:25578 | Persuader sex differences and peer pressure effects on attitudes toward drug abuse. | This experiment was performed to assess the effects of the experimental confederates' sex and contrived group peer pressure on the drug attitudes of male college students. Subjects were exposed to all-male or all-female groups of experimental confederates (ersuaders) who expressed either extremely pro-drug or anti-drug... | Persuader sex differences and peer pressure effects on attitudes toward drug abuse. This experiment was performed to assess the effects of the experimental confederates' sex and contrived group peer pressure on the drug attitudes of male college students. Subjects were exposed to all-male or all-female groups of experi... | [
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PMID:25579 | Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone sodium succinate. | Methotrexate sodium, cytarabine and hydrocortisone sodium succinate were evaluated in three vehicles, Sodium Chloride Injection, USP, Lactated Ringer's Injection, USP, and Elliott's B solution, an artificial cerebrospinal fluid (CSF). Osmolarity values of all drug solutions studied were within 10% of normal human. No v... | Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone sodium succinate. Methotrexate sodium, cytarabine and hydrocortisone sodium succinate were evaluated in three vehicles, Sodium Chloride Injection, USP, Lactated Ringer's Injection, USP, and Elliott's B solution, ... | [
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PMID:25580 | Prevalence of endocrine abnormalities in patients with the Zollinger-Ellison syndrome and in their families. | To evalute the frequency of associated and hereditary endocrinopathies in the Zollinger-Ellison syndrome, 10 patients with the syndrome were studied. In seven of them, coexisting endocrine disease was found. In six, the Zollinger-Ellison syndrome was probably a feature of multiple endocrine adenomatosis type I, whereas... | Prevalence of endocrine abnormalities in patients with the Zollinger-Ellison syndrome and in their families. To evalute the frequency of associated and hereditary endocrinopathies in the Zollinger-Ellison syndrome, 10 patients with the syndrome were studied. In seven of them, coexisting endocrine disease was found. In ... | [
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PMID:25581 | Cyclophosphamide-induced remissions in advanced polyarteritis nodosa. | Two patients with far advanced polyarteritis nodosa involving multiple organ systems and with aneurysm formation demonstrable by celiac axis and renal arteriograms were treated with oral cyclophosphamide, 1 to 2 mg/kg/day, and alternate day prednisone therapy. Dramatic remissions of disease activity were achieved withi... | Cyclophosphamide-induced remissions in advanced polyarteritis nodosa. Two patients with far advanced polyarteritis nodosa involving multiple organ systems and with aneurysm formation demonstrable by celiac axis and renal arteriograms were treated with oral cyclophosphamide, 1 to 2 mg/kg/day, and alternate day prednison... | [
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PMID:25582 | Biochemical evaluation of liver function. | Several chemistry tests for liver function are examined. Included are the transaminases, alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and bromsulphalein (BSP), as well as combinations of these and the ALP isoenzymes. | Biochemical evaluation of liver function. Several chemistry tests for liver function are examined. Included are the transaminases, alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and bromsulphalein (BSP), as well as combinations of these and the ALP isoenzymes. | [
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PMID:25583 | Adoption of a manual kinetic gamma-glutamyl transferase method in the clinical laboratory. | Following our recommended protocol for establishing analytical methods in a clinical laboratory, a rapid, simplified manual kinetic method for determining Gamma-Glutamyl Transferase activity in serum was adopted to meet the needs of our laboratory. The steps taken, from the selection of the assay conditions through the... | Adoption of a manual kinetic gamma-glutamyl transferase method in the clinical laboratory. Following our recommended protocol for establishing analytical methods in a clinical laboratory, a rapid, simplified manual kinetic method for determining Gamma-Glutamyl Transferase activity in serum was adopted to meet the needs... | [
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PMID:25584 | Immunologic aspects of malignancy. | Animal experimental studies and clinical observations closely relate the development and course of malignancy with immune function. The immune apparatus serves as a homeostatic system capable of recognizing "sell" from "non-self." Neoplasia is characterized by new surface components against which immune reactivity may ... | Immunologic aspects of malignancy. Animal experimental studies and clinical observations closely relate the development and course of malignancy with immune function. The immune apparatus serves as a homeostatic system capable of recognizing "sell" from "non-self." Neoplasia is characterized by new surface components a... | [
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PMID:25585 | Cardiac pacemakers in absence of the SA node: responses to exercise and autonomic blockade. | Surgical excision of the sinoatrial node, verified histologically, is followed by a supraventricular (atrial) rhythm in both resting and exercising dog whether anesthetized or conscious. The ECG is characterized by a definitive P wave and associated atrial electrograms. Waxing and waning in heart rate, generally referr... | Cardiac pacemakers in absence of the SA node: responses to exercise and autonomic blockade. Surgical excision of the sinoatrial node, verified histologically, is followed by a supraventricular (atrial) rhythm in both resting and exercising dog whether anesthetized or conscious. The ECG is characterized by a definitive ... | [
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PMID:25586 | Renal sugar transport in the winter flounder: V. secretion of 2-deoxy-D-galactose. | Isolated renal tubules and renal clearance techniques were used to characterize the renal handling of 2-deoxy-D-galactose (2-d-Gal) by the winter flounder (Pseudopleuronectes americanus). In vitro, energy-dependent, pH-sensitive uptake of 2-d-Gal (2-100 micron) was seen at the antiluminal face of the cell. Clearance me... | Renal sugar transport in the winter flounder: V. secretion of 2-deoxy-D-galactose. Isolated renal tubules and renal clearance techniques were used to characterize the renal handling of 2-deoxy-D-galactose (2-d-Gal) by the winter flounder (Pseudopleuronectes americanus). In vitro, energy-dependent, pH-sensitive uptake o... | [
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PMID:25588 | Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression. | Five of 8 patients with unipolar or bipolar endogenous depressions taking prolyl-leucyl-glycinamide (MIF-I), 75 mg/day, showed substantial improvement within a few days of beginning treatment compared with similar improvement in only 1 of 10 receiving 750 mg/day of MIF-I and only 1 of 5 patients taking placebo. The low... | Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression. Five of 8 patients with unipolar or bipolar endogenous depressions taking prolyl-leucyl-glycinamide (MIF-I), 75 mg/day, showed substantial improvement within a few days of beginning treatment compared with similar improvement in only 1 of ... | [
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PMID:25592 | The presence of collagenolytic cathepsin in uveal lysosomes of bovine eye. | Collagenolytic cathepsin, which can liberate soluble hydroxyproline-containing products from insoluble vitreous collagen with maximum activity at pH 3.5, was biochemically studied in uveal lysosomes of bovine eye. Collagen solubilization was proportional to both enzyme concentration and incubation time. When the enzyme... | The presence of collagenolytic cathepsin in uveal lysosomes of bovine eye. Collagenolytic cathepsin, which can liberate soluble hydroxyproline-containing products from insoluble vitreous collagen with maximum activity at pH 3.5, was biochemically studied in uveal lysosomes of bovine eye. Collagen solubilization was pro... | [
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PMID:25595 | [Aerobic blood sampling technique using the B 109-syringe (author's transl)]. | A syringe (B 109 Radiometer) for arterial blood sampling with modified aerobic technique is described. The blood sampling and subsequent storage during 2 h in ice water induces no clinically significant changes in the pH, pCO2 and pO2 of the blood. | [Aerobic blood sampling technique using the B 109-syringe (author's transl)]. A syringe (B 109 Radiometer) for arterial blood sampling with modified aerobic technique is described. The blood sampling and subsequent storage during 2 h in ice water induces no clinically significant changes in the pH, pCO2 and pO2 of the ... | [
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PMID:25598 | Identification of phosphates on the membranes of guinea pig sperm. | Guinea pig epididymal sperm, incubated for ATPases at pH 7.0 or pH 9.0, localize reaction product on both the periacrosomal segment of the plasmalemma and the outer acrosome membrane. In other species, e.g., rabbit, Ca++-ATPase is identified with the outer acrosome membrane. It may transport Ca++ into the acrosome for... | Identification of phosphates on the membranes of guinea pig sperm. Guinea pig epididymal sperm, incubated for ATPases at pH 7.0 or pH 9.0, localize reaction product on both the periacrosomal segment of the plasmalemma and the outer acrosome membrane. In other species, e.g., rabbit, Ca++-ATPase is identified with the o... | [
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PMID:25600 | [Mosquito studies on Hiddensee]. | The author reports on the biting activity of mosquitoes during the years 1957-77. His observations were made in the locality called "Duenenheide" on the island of Hiddensee, GDR. This "Duenenheide" is a heath-landscape with downs, situated near the village of Vitte. The daily rhythm of the mosquitoes is analyzed as wel... | [Mosquito studies on Hiddensee]. The author reports on the biting activity of mosquitoes during the years 1957-77. His observations were made in the locality called "Duenenheide" on the island of Hiddensee, GDR. This "Duenenheide" is a heath-landscape with downs, situated near the village of Vitte. The daily rhythm of ... | [
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PMID:25601 | Histochemical identification of fiber types in canine skeletal muscle. | Proximal and distal skeletal muscles from pectoral and pelvic limbs were histochemically examined in 18 neuromuscular disease-free dogs. On the basis of the human system of classification and nomenclature and results of standard adenosine triphosphatase (ATPase) and glycine-formaldehyde preincubation procedures, the fi... | Histochemical identification of fiber types in canine skeletal muscle. Proximal and distal skeletal muscles from pectoral and pelvic limbs were histochemically examined in 18 neuromuscular disease-free dogs. On the basis of the human system of classification and nomenclature and results of standard adenosine triphospha... | [
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PMID:25602 | Effect of liver microsome enzyme-inducing drugs on blood serum pentobarbital clearance and sleep time in sheep and rabbits. | Sheep were administered phenobarbital, diphenylhydantoin, chlorcyclizine, or phenylbutazone over 27 days. Rabbits were administered phenobarbital, diphenylhydantoin, or chlorcyclizine for 15 days. After the last treatment, pentobarbital was administered intravenously, and measurements were made of sleep time and blood ... | Effect of liver microsome enzyme-inducing drugs on blood serum pentobarbital clearance and sleep time in sheep and rabbits. Sheep were administered phenobarbital, diphenylhydantoin, chlorcyclizine, or phenylbutazone over 27 days. Rabbits were administered phenobarbital, diphenylhydantoin, or chlorcyclizine for 15 days.... | [
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PMID:25603 | Cytochemical demonstration of esterases in peripheral blood leukocytes. | Cytochemical methods for alpha naphthyl acetate esterase and chloroacetate esterase have been used to identify human monocytes and granulocytes. In this study, a standard procedure for staining alpha naphthyl acetate and chloroacetate esterase activities was modified by extending the range of pH of the incubation mixtu... | Cytochemical demonstration of esterases in peripheral blood leukocytes. Cytochemical methods for alpha naphthyl acetate esterase and chloroacetate esterase have been used to identify human monocytes and granulocytes. In this study, a standard procedure for staining alpha naphthyl acetate and chloroacetate esterase acti... | [
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PMID:25613 | [Flocculant interaction with native antibiotic solutions. The effect of flocculants on the quality indices of native solutions as dependent on a number of factors]. | Flocculants had a significant effect on the characteristics of the fermentation broth filtrates of some antibiotics. They decreased the filtrate turbidity, concentration of the organic ballast, etc. The size of the floccules depended on a number of factors, including the fluocculant concentration, agitation rate, conce... | [Flocculant interaction with native antibiotic solutions. The effect of flocculants on the quality indices of native solutions as dependent on a number of factors]. Flocculants had a significant effect on the characteristics of the fermentation broth filtrates of some antibiotics. They decreased the filtrate turbidity,... | [
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PMID:25614 | [Rifamycin in B distribution between aqueous and organic phases]. | Dependence of the coefficient of rifamycin B distribution in the system of butyl acetate-buffer solution on pH of the equilibrium acqueous phase, antibiotic concentration in the solution and temperature was studied. It was shown that the coefficient value did not depend on the antibiotic concentration within 1000-2000 ... | [Rifamycin in B distribution between aqueous and organic phases]. Dependence of the coefficient of rifamycin B distribution in the system of butyl acetate-buffer solution on pH of the equilibrium acqueous phase, antibiotic concentration in the solution and temperature was studied. It was shown that the coefficient valu... | [
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PMID:25615 | Physiological conditions affecting Staphylococcus aureus susceptibility to staphylococcin 1580. | Loss of salt tolerance, irreversible loss of viability, inhibition of l-glutamic acid uptake and effects on the high energy state of the membrane were used as parameters to measure the injury induced by staphylococcin 1580, a bacteriocin of Staphylococcus epidermidis, in susceptible cells of Staphylococcus aureus Oxfor... | Physiological conditions affecting Staphylococcus aureus susceptibility to staphylococcin 1580. Loss of salt tolerance, irreversible loss of viability, inhibition of l-glutamic acid uptake and effects on the high energy state of the membrane were used as parameters to measure the injury induced by staphylococcin 1580, ... | [
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PMID:25616 | Partial characterization of a beta-lactamase from Vibrio parahaemolyticus by a new automated microiodometric technique. | A number of characteristics were determined with a new automated method for a partially purified beta-lactamase from Vibrio parahaemolyticus. The enzyme had a molecular weight of 28,000 by gel filtration, a pH optimum between 6.5 and 7.0, and a temperature optimum at 36 degrees C. With penicillin G as the substrate, th... | Partial characterization of a beta-lactamase from Vibrio parahaemolyticus by a new automated microiodometric technique. A number of characteristics were determined with a new automated method for a partially purified beta-lactamase from Vibrio parahaemolyticus. The enzyme had a molecular weight of 28,000 by gel filtrat... | [
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PMID:25617 | Secretion of cell wall polymers into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis. | Autolysin-defective pneumococci secrete into the growth medium choline-containing macromolecules during treatment with any one of a large number of inhibitors of cell wall biosynthesis, including beta-lactams, beta-halogeno-d-alanines, cephalosporins, and d-cycloserine. Secretion is closely related to the dose response... | Secretion of cell wall polymers into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis. Autolysin-defective pneumococci secrete into the growth medium choline-containing macromolecules during treatment with any one of a large number of inhibito... | [
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PMID:25618 | Characterization of cell wall polymers secreted into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis. | Autolysin-defective pneumococci secrete large quantities of choline-containing cell wall polymers into the growth medium during treatment with inhibitors of peptidoglycan synthesis. The secreted polymers were separated into three fractions by a combination of gel filtration on agarose and sodium dodecyl sulfate-gel ele... | Characterization of cell wall polymers secreted into the growth medium of lysis-defective pneumococci during treatment with penicillin and other inhibitors of cell wall synthesis. Autolysin-defective pneumococci secrete large quantities of choline-containing cell wall polymers into the growth medium during treatment wi... | [
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PMID:25620 | Production of trypsin inhibitor by a Cephalosporium sp. | Conditions for the production of the trypsin inhibitor from Cephalosporium sp. KM 388 were investigated. Polypeptone-meat extract-glucose medium supported excellent production of the trypsin inhibitor. In this medium, polypeptone and meat extract were utilized both as carbon and nitrogen sources and as limiting substra... | Production of trypsin inhibitor by a Cephalosporium sp. Conditions for the production of the trypsin inhibitor from Cephalosporium sp. KM 388 were investigated. Polypeptone-meat extract-glucose medium supported excellent production of the trypsin inhibitor. In this medium, polypeptone and meat extract were utilized bot... | [
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PMID:25621 | Role of lime treatment in the removal of bacteria, enteric viruses, and coliphages in a wastewater reclamation plant. | Lime flocculation/sedimentation in the first process unit of a 4,500-m3/day wastewater reclamation plant reduced numbers of microorganisms extensively when operated at pH 11.2. The efficiency was much less at lower pH values, and some bacteria even multiplied at pH 9.6. Data on reduction in the number of microorganisms... | Role of lime treatment in the removal of bacteria, enteric viruses, and coliphages in a wastewater reclamation plant. Lime flocculation/sedimentation in the first process unit of a 4,500-m3/day wastewater reclamation plant reduced numbers of microorganisms extensively when operated at pH 11.2. The efficiency was much l... | [
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PMID:25622 | Hydrogen production by Anabaena cylindrica: effects of varying ammonium and ferric ions, pH, and light. | Anabaena cylindrica sparged with argon gas produced H2 continuously for 30 days under limited light conditions (6.0 W/m2) and for 18 days under elevated light conditions (32 W/m2) in the absence of exogenous nitrogen. The efficiency of converting visible light energy (32 W/m2) into chemical energy that is trapped as H2... | Hydrogen production by Anabaena cylindrica: effects of varying ammonium and ferric ions, pH, and light. Anabaena cylindrica sparged with argon gas produced H2 continuously for 30 days under limited light conditions (6.0 W/m2) and for 18 days under elevated light conditions (32 W/m2) in the absence of exogenous nitrogen... | [
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PMID:25623 | Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans. | A preparative-scale regiospecific conversion of 10,11-dimethoxyaporphine to isoapocodeine was conducted with Cunninghamella elegans ATCC 9245. This biotransformation proceeded quantitatively in suspensions and was pH dependent. The influence of antioxidants on the conversion was studied. Attempts to preserve the activi... | Regiospecific synthesis of isoapocodeine from 10,11-dimethoxyaporphine by using Cunninghamella elegans. A preparative-scale regiospecific conversion of 10,11-dimethoxyaporphine to isoapocodeine was conducted with Cunninghamella elegans ATCC 9245. This biotransformation proceeded quantitatively in suspensions and was pH... | [
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PMID:25624 | Immobilization of Aspergillus beta-glucosidase on chitosan. | beta-Glucosidase of Aspergillus phoenicis QM 329 was immobilized on chitosan, using the bifunctional agent glutaraldehyde. The most active preparation based on the amount of support contained a 1:2.5 enzyme-to-chitosan ratio (wt/wt). However, the specific activity of the bound enzyme decreased from 10 to 1% with increa... | Immobilization of Aspergillus beta-glucosidase on chitosan. beta-Glucosidase of Aspergillus phoenicis QM 329 was immobilized on chitosan, using the bifunctional agent glutaraldehyde. The most active preparation based on the amount of support contained a 1:2.5 enzyme-to-chitosan ratio (wt/wt). However, the specific acti... | [
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PMID:25625 | Physiology of L-asparaginase synthesis in recombinants of Escherichia coli A-1. | A mating between Escherichia coli 4318 (thi leu Las- Hfr) and E. coli A-1 (Met- Las+ F-) resulted in the formation of prototrophic recombinants having L-asparaginase activities at three distinct levels. The physiology of L-asparaginase synthesis in these recombinants is decribed. One class of recombinants produced sign... | Physiology of L-asparaginase synthesis in recombinants of Escherichia coli A-1. A mating between Escherichia coli 4318 (thi leu Las- Hfr) and E. coli A-1 (Met- Las+ F-) resulted in the formation of prototrophic recombinants having L-asparaginase activities at three distinct levels. The physiology of L-asparaginase synt... | [
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PMID:25626 | PR toxin production in different Penicillium roqueforti strains. | Different Penicillium roqueforti strains from the American Type Culture Collection were tested for the production of PR toxin. All four strains were able to produce the toxin on semisynthetic medium at 24 degrees C after certain periods of incubation. The yields were correlated with the pH of the medium. Timing of the ... | PR toxin production in different Penicillium roqueforti strains. Different Penicillium roqueforti strains from the American Type Culture Collection were tested for the production of PR toxin. All four strains were able to produce the toxin on semisynthetic medium at 24 degrees C after certain periods of incubation. The... | [
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PMID:25628 | Endocrine studies in Fanconi's anaemia. Report of 4 cases. | Four boys with Fanconi's anaemia and growth hormone (GH) deficiency are reported. Case 1 had isolated GH deficiency and responded to HGH and to oxandrolone treatment. Case 2, his brother, had milder haematological and dysmorphic manifestations and maintained a low-normal growth rate without treatment in spite of labora... | Endocrine studies in Fanconi's anaemia. Report of 4 cases. Four boys with Fanconi's anaemia and growth hormone (GH) deficiency are reported. Case 1 had isolated GH deficiency and responded to HGH and to oxandrolone treatment. Case 2, his brother, had milder haematological and dysmorphic manifestations and maintained a ... | [
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PMID:25629 | Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle. | Twenty-two prepubertal children with unilateral cryptorchidism were treated. None had undergone previous medical or surgical to modify the abnormal position of the testes, all of which were located inthe inguinal canal. Treatment was with luteinising hormone-releasing hormone (LH-RH) nasal spray given for 7 days. 9 boy... | Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle. Twenty-two prepubertal children with unilateral cryptorchidism were treated. None had undergone previous medical or surgical to modify the abnormal position of the testes, all of which were located inthe inguinal canal. Treatment was... | [
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PMID:25631 | Acute response to acid-base stress. | A method previously established in the experimental animal for predicting the acute response to either metabolic stress (bicarbonate administration) or respiratory stress(manipulation of oxygenator gas during cardiopulmonary bypass) has been extended to man. The method is based on a single nomogram. The accuracy of the... | Acute response to acid-base stress. A method previously established in the experimental animal for predicting the acute response to either metabolic stress (bicarbonate administration) or respiratory stress(manipulation of oxygenator gas during cardiopulmonary bypass) has been extended to man. The method is based on a ... | [
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PMID:25632 | Renal concentration gradients of salicylic acid and its metabolic congeners in the dog. | Salicylic acid and its principal metabolic product, salicyluric acid, are ultrafiltered at the glomeruli, secreted by the proximal segment and undergo back diffusion; the net effect being an accumulation of salicylates in the cortex. The back diffusion of salicylate is pH-sensitive (salicylurate is not) and its secreti... | Renal concentration gradients of salicylic acid and its metabolic congeners in the dog. Salicylic acid and its principal metabolic product, salicyluric acid, are ultrafiltered at the glomeruli, secreted by the proximal segment and undergo back diffusion; the net effect being an accumulation of salicylates in the cortex... | [
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PMID:25633 | Effects of l-penbutolol (Hoe 893d) on the transmembrane potentials of canine purkinje fibers and ventricular muscle fibers. | Intrinsic membrane effects (non-specific effects) and beta-adrenergic blocking action (specific effects) of l-penbutolol were studied using intracellular microelectrode techniques. l-Penbutolol in concentrations above 0.1 mg/L reduced the maximum rate of depolarization at phase O of both Purkinje fibers and ventricular... | Effects of l-penbutolol (Hoe 893d) on the transmembrane potentials of canine purkinje fibers and ventricular muscle fibers. Intrinsic membrane effects (non-specific effects) and beta-adrenergic blocking action (specific effects) of l-penbutolol were studied using intracellular microelectrode techniques. l-Penbutolol in... | [
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PMID:25634 | Inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, RU 31156. | RU 31156, the tris-(hydroxymethyl)-aminomethane salt of 7-(S-methylsulphonimidoyl)-5-(n-hexyl)-xanthen-9-one-2-carboxylic acid has been found to be a potent inhibitor of experimental immediate hypersensitivity reactions in vivo. In the IgE-mediated rat PCA test, RU 31156 had an ED50 of 0.0046 (00037--0.0057) mg/kg whic... | Inhibition of experimental immediate hypersensitivity reactions by a novel xanthone, RU 31156. RU 31156, the tris-(hydroxymethyl)-aminomethane salt of 7-(S-methylsulphonimidoyl)-5-(n-hexyl)-xanthen-9-one-2-carboxylic acid has been found to be a potent inhibitor of experimental immediate hypersensitivity reactions in vi... | [
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PMID:25635 | Acute nephritis and pulmonary alveolitis following pneumococcal pneumonia. | Acute glomerulonephritis developed in a man with pneumococcal pneumonia. Serum complement studies revealed decreased levels of C4, properdin, and C3. Renal immunofluorescence studies demonstrated pneumococcal antigen, C1q, C4, C3 proactivator, properdin, C3, IgG, and IgM. Circulating cryoglobulin contained pneumococcal... | Acute nephritis and pulmonary alveolitis following pneumococcal pneumonia. Acute glomerulonephritis developed in a man with pneumococcal pneumonia. Serum complement studies revealed decreased levels of C4, properdin, and C3. Renal immunofluorescence studies demonstrated pneumococcal antigen, C1q, C4, C3 proactivator, p... | [
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PMID:25636 | Effects of host aging, ions, and pH on the adsorption of the cyanovirus N-1 to Nostoc muscorum. | The adsorption rate of the cyanovirus N-1 infecting the nitrogen-fixing blue-green alga Nostocmuscorum decreased with aging of algal cultures and the virus failed to adsorb to the dead host cells. The adsorption rate declined in saline magnesium chloride solution compared to that in algal growth medium. The addition of... | Effects of host aging, ions, and pH on the adsorption of the cyanovirus N-1 to Nostoc muscorum. The adsorption rate of the cyanovirus N-1 infecting the nitrogen-fixing blue-green alga Nostocmuscorum decreased with aging of algal cultures and the virus failed to adsorb to the dead host cells. The adsorption rate decline... | [
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PMID:25639 | A comparative study of five commercial reagents for the Coulter Model S: a proposed method for reagent evaluation. | A comparative study of five competitive commercial reagents for the Coulter Model S was performed jointly by two large, busy hospital laboratories with active quality control programs. Both laboratories, independently using the same reagent systems, studied 20 consecutive blood samples from patients from their own resp... | A comparative study of five commercial reagents for the Coulter Model S: a proposed method for reagent evaluation. A comparative study of five competitive commercial reagents for the Coulter Model S was performed jointly by two large, busy hospital laboratories with active quality control programs. Both laboratories, i... | [
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PMID:25642 | Acidification of rat colon with lactulose. Its effects on the healing of colonic anastomoses. | Preoperative preparation of rats with lactulose, 2.5 ml/kg of a 52.5% w/w solution, for two days resulted in increased bursting pressure and bursting wall tension of low colonic anastomoses three days postoperatively when compared with unprepared controls (85.8, viz, 36.1 mm Hg and 0.55, viz, 0.19 dynes/cm X 10(-5). Af... | Acidification of rat colon with lactulose. Its effects on the healing of colonic anastomoses. Preoperative preparation of rats with lactulose, 2.5 ml/kg of a 52.5% w/w solution, for two days resulted in increased bursting pressure and bursting wall tension of low colonic anastomoses three days postoperatively when comp... | [
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PMID:25644 | Instability of the bovine MOR-2AB (mitochondrial malate: NAD oxidoreductase) heterodimeric molecule of heterozygous subjects after isoelectric focusing. | The heterodimeric molecule which is characteristic of animals heterozygous for the MOR-2 polymorphism and which is readily seen on enzymograms after electrophoresis is reported to be absent from zymograms performed after isoelectric focusing. A possible explanation is presented based on monomer--dimer equilibrium at pH... | Instability of the bovine MOR-2AB (mitochondrial malate: NAD oxidoreductase) heterodimeric molecule of heterozygous subjects after isoelectric focusing. The heterodimeric molecule which is characteristic of animals heterozygous for the MOR-2 polymorphism and which is readily seen on enzymograms after electrophoresis is... | [
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PMID:25645 | Biochemical genetics of a new glucosephosphate isomerase allele (Gpi-1c) from wild mice. | We have found a new allele at the structural locus for glucosephosphate isomerase (called Gpi-1c) in a population of wild mice. The Gpi-1c allele codes for an enzyme of greater cathodal electrophoretic mobility than either the Gpi-1a or Gpi-1b alleles found in the wild and in the SM/J and C57BL/6J inbred strains. Mice ... | Biochemical genetics of a new glucosephosphate isomerase allele (Gpi-1c) from wild mice. We have found a new allele at the structural locus for glucosephosphate isomerase (called Gpi-1c) in a population of wild mice. The Gpi-1c allele codes for an enzyme of greater cathodal electrophoretic mobility than either the Gpi-... | [
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