id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:25646 | Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives. | By using cell-free preparations of rat liver it was shown that the removal of the 14alpha-methyl group (C-32) of steroids containing either a delta7(8) or a delta8(9) double bond is attended exclusively by the formation of the corresponding 7,14- and 8,14-dienes respectively (structures of types III and VIII). Cumulati... | Chemical and enzymic studies on the characterization of intermediates during the removal of the 14alpha-methyl group in cholesterol biosynthesis. The use of 32-functionalized lanostane derivatives. By using cell-free preparations of rat liver it was shown that the removal of the 14alpha-methyl group (C-32) of steroids ... | [
-0.060293007642030716,
-0.03936437889933586,
-0.032202206552028656,
-0.00645252363756299,
0.021019309759140015,
-0.02503170445561409,
-0.04685353487730026,
0.005834322888404131,
-0.009424200281500816,
-0.03265722468495369,
0.037880923599004745,
-0.08248525857925415,
0.0460575707256794,
-0.... |
PMID:25647 | Magnetic coupling of the molybdenum and iron-sulphur centres in xanthine oxidase and xanthine dehydrogenases. | Magnetic interaction between molybdenum and one of the iron-sulphur centres in milk xanthine oxidase [Lowe, Lynden-Bell & Bray (1972) Biochem. J. 130, 239-249] was studied further, with particular reference to the newly discovered Mo(V) e.p.r.(electron-paramagnetic-resonance) signal, Resting II [Lowe, Barber, Pawli... | Magnetic coupling of the molybdenum and iron-sulphur centres in xanthine oxidase and xanthine dehydrogenases. Magnetic interaction between molybdenum and one of the iron-sulphur centres in milk xanthine oxidase [Lowe, Lynden-Bell & Bray (1972) Biochem. J. 130, 239-249] was studied further, with particular reference... | [
-0.06336554139852524,
0.0441594198346138,
-0.06364443153142929,
0.0385175384581089,
0.040808744728565216,
-0.057602498680353165,
0.021478239446878433,
0.03883451595902443,
-0.059805285185575485,
-0.05507294833660126,
0.00247392849996686,
-0.09256843477487564,
-0.003688169876113534,
-0.0297... |
PMID:25648 | Pyruvate carboxylase from a thermophilic Bacillus. Studies on the specificity of activation by acyl derivatives of coenzyme A and on the properties of catalysis in the absence of activator. | 1. Oxaloacetate synthesis catalysed by pyruvate carboxylase from a thermophilic Bacillus in the absence of acetyl-CoA required addition of high concentrations of pyruvate, MgATP(2-) and HCO(3) (-), and at 45 degrees C occurred at a maximum rate approx. 20% of that in the presence of a saturating concentration of acetyl... | Pyruvate carboxylase from a thermophilic Bacillus. Studies on the specificity of activation by acyl derivatives of coenzyme A and on the properties of catalysis in the absence of activator. 1. Oxaloacetate synthesis catalysed by pyruvate carboxylase from a thermophilic Bacillus in the absence of acetyl-CoA required add... | [
-0.07275459170341492,
-0.010255826637148857,
-0.04778440669178963,
0.016527190804481506,
0.02612737938761711,
-0.012799061834812164,
0.011876357719302177,
0.023112185299396515,
-0.07776792347431183,
-0.045294515788555145,
0.04460401087999344,
-0.09121548384428024,
0.0036727790720760822,
0.... |
PMID:25649 | The isolation and properties of a non-pepsin proteinase from human gastric mucosa. | 1. A non-pepsin proteinase, proteinase 2, was successfully isolated free from pepsinogen (by repetitive chromatography on DEAE- and CM-celluloses) from the gastric mucosa of a patient with a duodenal ulcer and the uninvaded mucosa of a patient with a gastric adenocarcinoma. 2. Proteinases 1a and 1b, found in gastric ad... | The isolation and properties of a non-pepsin proteinase from human gastric mucosa. 1. A non-pepsin proteinase, proteinase 2, was successfully isolated free from pepsinogen (by repetitive chromatography on DEAE- and CM-celluloses) from the gastric mucosa of a patient with a duodenal ulcer and the uninvaded mucosa of a p... | [
-0.06019647791981697,
-0.018073853105306625,
-0.04561521112918854,
0.011021750047802925,
-0.0046473280526697636,
-0.05021827295422554,
0.06544876843690872,
0.04122850298881531,
-0.03210698068141937,
-0.04906434193253517,
0.017292313277721405,
-0.10067502409219742,
-0.03587503358721733,
0.0... |
PMID:25650 | The biochemical pathway for the breakdown of N4-ethyl-L-asparagine in the bacterium Pseudomonas stutzeri. | N4-Ethyl-L-[u-14C]asparagine and L-[U-14C]aspartate give identical metabolites, mainly intermediates of the tricarboxylic acid cycle and related amino acids, in whole cells of Pseudomonas stutzeri. The labelled asparagine derivative is converted into [14C]-aspartate by cell-free extracts, and this reaction, which has a... | The biochemical pathway for the breakdown of N4-ethyl-L-asparagine in the bacterium Pseudomonas stutzeri. N4-Ethyl-L-[u-14C]asparagine and L-[U-14C]aspartate give identical metabolites, mainly intermediates of the tricarboxylic acid cycle and related amino acids, in whole cells of Pseudomonas stutzeri. The labelled asp... | [
-0.036708518862724304,
0.009941130876541138,
-0.062488432973623276,
0.053746890276670456,
0.0568091981112957,
-0.02167709916830063,
0.048946116119623184,
0.042068399488925934,
-0.0733475536108017,
0.03901591897010803,
0.04768658056855202,
-0.045416459441185,
0.057782143354415894,
0.0230027... |
PMID:25651 | The microbial metabolism of Cl compounds. The stoicheiometry of respiration-driven proton translocation in Pseudomonas AM1 and in a mutant lacking cytochrome c. | This paper clarifies the role of cytochrome c in Pseudomonas AM1 by measuring the stoicheiometry of proton translocation driven by respiration of endogenous or added substrates in wild-type bacteria and in a mutant lacking cytochrome c (mutant PCT76). The maximum -->H(+)/O ratio (protons translocated out of the bact... | The microbial metabolism of Cl compounds. The stoicheiometry of respiration-driven proton translocation in Pseudomonas AM1 and in a mutant lacking cytochrome c. This paper clarifies the role of cytochrome c in Pseudomonas AM1 by measuring the stoicheiometry of proton translocation driven by respiration of endogenous or... | [
-0.05466838926076889,
-0.017546335235238075,
-0.06449246406555176,
0.022307420149445534,
0.04293954372406006,
-0.07186020910739899,
0.005318003240972757,
-0.02008635923266411,
-0.016821205615997314,
-0.012955035082995892,
0.05279991403222084,
-0.08387722074985504,
0.03406475856900215,
0.05... |
PMID:25652 | Regulation of the oxidative phase of the pentose phosphate cycle in mussels. | 1. The mechanisms that control the oxidative phase of the pentose phosphate cycle in mussel hepatopancreas were investigated. 2. The effects of GSSG (oxidized glutathione) on the inhibition of glucose 6-phosphate dehydrogenase by NADPH [Eggleston & Krebs (1974) Biochem. J. 138, 425-435] extend to 6-phosphogluconate... | Regulation of the oxidative phase of the pentose phosphate cycle in mussels. 1. The mechanisms that control the oxidative phase of the pentose phosphate cycle in mussel hepatopancreas were investigated. 2. The effects of GSSG (oxidized glutathione) on the inhibition of glucose 6-phosphate dehydrogenase by NADPH [Eggles... | [
0.0005772565491497517,
-0.021205032244324684,
-0.003813286777585745,
-0.0349833182990551,
0.03370396047830582,
-0.05586279183626175,
0.009665426798164845,
-0.007884482853114605,
-0.10065183788537979,
-0.009378193877637386,
-0.0017573762452229857,
-0.06322278082370758,
0.005692676641047001,
... |
PMID:25653 | Proton translocation of the bovine chromaffin-granule membrane. | Bovine chromaffin granules were lysed and their membranes resealed to give osmotically sensitive 'ghosts'. These swell in the presence of salts and MgATP. It is shown that this is due to proton entry accompanied by anions. The rate of swelling depends on the anion present, but swelling is not limited to media containin... | Proton translocation of the bovine chromaffin-granule membrane. Bovine chromaffin granules were lysed and their membranes resealed to give osmotically sensitive 'ghosts'. These swell in the presence of salts and MgATP. It is shown that this is due to proton entry accompanied by anions. The rate of swelling depends on t... | [
-0.05677549168467522,
-0.019557904452085495,
-0.023023469373583794,
0.009468771517276764,
0.012940363958477974,
-0.045727308839559555,
0.06308753043413162,
-0.0011539747938513756,
0.006415593903511763,
-0.012711819261312485,
0.04843864589929581,
-0.09176433086395264,
-0.03041050396859646,
... |
PMID:25654 | Hydroxytryptamine transport by the bovine chromaffin-granule membrane. | 5-Hydroxytryptamine is accumulated by resealed chromaffin-granule 'ghosts' if a pH gradient (acid inside) is imposed across their membranes by preincubating them at low pH. This uptake, like that driven by MgATP, is reserpine- and uncoupler-sensitive. This strongly suggests that catecholamines are taken up by intact gr... | Hydroxytryptamine transport by the bovine chromaffin-granule membrane. 5-Hydroxytryptamine is accumulated by resealed chromaffin-granule 'ghosts' if a pH gradient (acid inside) is imposed across their membranes by preincubating them at low pH. This uptake, like that driven by MgATP, is reserpine- and uncoupler-sensitiv... | [
-0.05571144446730614,
-0.01730196736752987,
-0.008466268889605999,
0.05983535200357437,
0.01587294042110443,
-0.027276182547211647,
0.10404053330421448,
0.0370221845805645,
-0.047999728471040726,
-0.03769536316394806,
0.015711352229118347,
-0.05018239468336105,
-0.026698246598243713,
0.059... |
PMID:25655 | Contribution of cytochromes and proteins to the effect of ascorbic acid on artificial and microsomal hydroxylation systems containing oxygen and hydrogen peroxide. | Hydroxylation systems containing cytochromes, proteins and ascorbic acid were studied at physiological pH (7.4) under O2 or N2 with added H2O2. Proteins inhibited aromatic hydroxylation of p-nitrophenol or oxidative demethylation of ethylmorphine in ascorbic acid-containing systems incubated under O2, but strongly acti... | Contribution of cytochromes and proteins to the effect of ascorbic acid on artificial and microsomal hydroxylation systems containing oxygen and hydrogen peroxide. Hydroxylation systems containing cytochromes, proteins and ascorbic acid were studied at physiological pH (7.4) under O2 or N2 with added H2O2. Proteins inh... | [
-0.09215990453958511,
0.06345802545547485,
-0.058807048946619034,
0.08077181130647659,
-0.00413338141515851,
-0.04367976635694504,
0.0693042129278183,
-0.0037302912678569555,
-0.015995332971215248,
0.036422621458768845,
0.03708541765809059,
-0.02790404111146927,
-0.024344343692064285,
0.01... |
PMID:25656 | Evidence for a pH-dependent irreversible formation of a stable conformation of phenacyl-alpha-chymotrypsin. | A reinvestigation of the modification reactions of alpha-chymotrypsin with phenacyl bromide was carried out. Results conclusively demonstrate that the chemically and physically different modified enzymes prepared at pH 4 and at pH 7 both contain the phenacyl group at methionine-192 in the sulphonium salt form. Evidence... | Evidence for a pH-dependent irreversible formation of a stable conformation of phenacyl-alpha-chymotrypsin. A reinvestigation of the modification reactions of alpha-chymotrypsin with phenacyl bromide was carried out. Results conclusively demonstrate that the chemically and physically different modified enzymes prepared... | [
-0.11883474141359329,
0.010002166032791138,
-0.061710115522146225,
-0.0031413985416293144,
0.0016267449827864766,
-0.010434462688863277,
0.040761347860097885,
-0.000985694001428783,
-0.06345535814762115,
-0.03808318451046944,
0.04589049518108368,
-0.029593270272016525,
-0.009506048634648323,... |
PMID:25657 | Pressure relaxation of the equilibrium of the pig heart lactate dehydrogenase system. | The relaxation behaviour of a system of reactants equilibrated in the presence of pig heart lactate dehydrogenase was studied after pressure perturbation. Two relaxations were observed when protein fluorescence was recorded, but only the slower relaxation was apparent in observations of A340. The faster relaxation ther... | Pressure relaxation of the equilibrium of the pig heart lactate dehydrogenase system. The relaxation behaviour of a system of reactants equilibrated in the presence of pig heart lactate dehydrogenase was studied after pressure perturbation. Two relaxations were observed when protein fluorescence was recorded, but only ... | [
-0.07273118942975998,
0.035523317754268646,
-0.008359651081264019,
0.04973061382770538,
-0.0008010701276361942,
-0.01335294172167778,
0.04000723734498024,
-0.03257368877530098,
0.005197463557124138,
-0.04634706676006317,
-0.011470483615994453,
-0.07434134185314178,
0.027453012764453888,
-0... |
PMID:25658 | Pyruvate-to-ethanol pathway in Entamoeba histolytica. | The pyruvate-to-ethanol pathway in Entamoeba histolytica is unusual when compared with most investigated organisms. Pyruvate decarboxylase (EC 4.1.1.1), a key enzyme for ethanol production, is not found. Pyruvate is converted into acetyl-CoA and CO2 by the enzyme pyruvate synthase (EC 1.2.7.1), which has been demonstra... | Pyruvate-to-ethanol pathway in Entamoeba histolytica. The pyruvate-to-ethanol pathway in Entamoeba histolytica is unusual when compared with most investigated organisms. Pyruvate decarboxylase (EC 4.1.1.1), a key enzyme for ethanol production, is not found. Pyruvate is converted into acetyl-CoA and CO2 by the enzyme py... | [
-0.02487579733133316,
-0.03426963463425636,
-0.04799072444438934,
0.018282057717442513,
0.06902863085269928,
-0.035374950617551804,
-0.0018367988523095846,
0.0340336337685585,
-0.027848193421959877,
-0.025703132152557373,
0.05232220143079758,
-0.08363199234008789,
-0.018089009448885918,
-0... |
PMID:25659 | DNA polymerases from Chlamydomonas reinhardii. Purification and properties. | Three DNA polymerase activities, A, B and C, were identified in extracts of exponentially growing synchronous cultures of Chlamydomonas reinhardii, and DNA polymerases A and B were characterized in detail. Both enzymes have the same binding affinity for DEAE-cellulose at pH 7.8, but can be distinguished from each other... | DNA polymerases from Chlamydomonas reinhardii. Purification and properties. Three DNA polymerase activities, A, B and C, were identified in extracts of exponentially growing synchronous cultures of Chlamydomonas reinhardii, and DNA polymerases A and B were characterized in detail. Both enzymes have the same binding aff... | [
-0.05640396103262901,
-0.002828881610184908,
-0.05749506875872612,
0.021995633840560913,
0.031255852431058884,
0.011540530249476433,
0.05557882413268089,
0.031049467623233795,
-0.052070584148168564,
-0.006705275736749172,
0.006009032018482685,
-0.0333038792014122,
-0.05667051300406456,
-0.... |
PMID:25660 | The purification and properties of urocanase from Pseudomonas testosteroni. | Urocanase (urocanate hydratase, EC 4.2.1.49) purified from Pseudomonas testosteroni has a mol.wt. of 118000 determined by sedimentation-equilibrium analysis. Ultracentrifugation in 6M-guanidine hydrochloride and polyacrylamide-gel electrophoresis in sodium dodecyl sulphate show that the enzyme consists of two identical... | The purification and properties of urocanase from Pseudomonas testosteroni. Urocanase (urocanate hydratase, EC 4.2.1.49) purified from Pseudomonas testosteroni has a mol.wt. of 118000 determined by sedimentation-equilibrium analysis. Ultracentrifugation in 6M-guanidine hydrochloride and polyacrylamide-gel electrophores... | [
-0.061114292591810226,
0.022572176530957222,
-0.07141558825969696,
0.04251028224825859,
0.02803930826485157,
-0.01848587580025196,
0.007720389403402805,
0.025780046358704567,
-0.04944772645831108,
-0.01223086379468441,
-0.005482789129018784,
-0.04773297160863876,
0.010693545453250408,
-0.0... |
PMID:25661 | A reappraisal of the reaction of butyryl-coenzyme A dehydrogenase with phenylmercuric acetate. Evidence that de-greening involves a reaction of the tightly bound thioester. | Phenylmercuric acetate reversibly de-greens butyryl-CoA dehydrogenase from Megasphaera elsdenii, abolishing the absorption band at 710nm. The view that this is a result of modification of a protein thiol group is re-examined in the light of the following new observations. (i) After treatment with phenylmercuric acetate... | A reappraisal of the reaction of butyryl-coenzyme A dehydrogenase with phenylmercuric acetate. Evidence that de-greening involves a reaction of the tightly bound thioester. Phenylmercuric acetate reversibly de-greens butyryl-CoA dehydrogenase from Megasphaera elsdenii, abolishing the absorption band at 710nm. The view ... | [
-0.07502837479114532,
-0.004135396331548691,
-0.041100431233644485,
0.04871653392910957,
0.04212167486548424,
-0.04632791876792908,
-0.009787452407181263,
0.006798943039029837,
-0.05610698089003563,
-0.009750303812325,
0.031624071300029755,
-0.07752957940101624,
0.033473338931798935,
-0.00... |
PMID:25662 | A study of the enhanced toxicity of doxapram in rodents treated with narcotic analgesics. | It has been shown in both mice and rats that the LD50 value for doxapram is reduced in rodents treated with narcotic analgesics. In both species the site of the toxic interaction appears to be the cardiovascular system. Doxapram alone, in sub-lethal doses, appears to cause conduction defects in the heart and this actio... | A study of the enhanced toxicity of doxapram in rodents treated with narcotic analgesics. It has been shown in both mice and rats that the LD50 value for doxapram is reduced in rodents treated with narcotic analgesics. In both species the site of the toxic interaction appears to be the cardiovascular system. Doxapram a... | [
-0.042224690318107605,
0.00600699195638299,
0.04978867247700691,
0.015474625863134861,
0.02015986107289791,
-0.02541990578174591,
0.04330125078558922,
0.06885351240634918,
-0.04275282844901085,
-0.03217234089970589,
-0.0020614787936210632,
-0.004943524487316608,
0.037029825150966644,
0.051... |
PMID:25663 | Lorazepam, hyoscine and atropine as i.v. surgical premedicants. | Lorazepam 2 and 4 mg alone and in combination with atropine 0.4 mg and hyoscine 0.4 mg were studied as i.v. surgical premedicants in 150 patients. Relief of anxiety, sedation, patient acceptance, lack of recall and side-effects were evaluated. Hyoscine was found to improve the relief of anxiety and sedation associated ... | Lorazepam, hyoscine and atropine as i.v. surgical premedicants. Lorazepam 2 and 4 mg alone and in combination with atropine 0.4 mg and hyoscine 0.4 mg were studied as i.v. surgical premedicants in 150 patients. Relief of anxiety, sedation, patient acceptance, lack of recall and side-effects were evaluated. Hyoscine was... | [
-0.045457374304533005,
0.016775641590356827,
0.03312606364488602,
0.06523947417736053,
-0.006481959950178862,
0.012724116444587708,
0.026523638516664505,
0.06910265237092972,
-0.0018900762079283595,
-0.0469827800989151,
-0.04468856379389763,
0.03109462931752205,
0.024614941328763962,
0.017... |
PMID:25664 | Exacerbations of chronic bronchitis: exogenous or endogenous infection? | Six male patients with chronic bronchitis, who were known previously to have excreted Streptococcus pneumoniae and/or Haemophilus influenzae, both at the times of exacerbations and during remission, were studied for 43 to 52 months. Sputum was examined fortnightly and at the time of exacerbations. Strains of Strep. pne... | Exacerbations of chronic bronchitis: exogenous or endogenous infection? Six male patients with chronic bronchitis, who were known previously to have excreted Streptococcus pneumoniae and/or Haemophilus influenzae, both at the times of exacerbations and during remission, were studied for 43 to 52 months. Sputum was exam... | [
-0.008884059265255928,
0.021351974457502365,
0.03277922421693802,
0.0010187902953475714,
0.07947710156440735,
-0.04385349527001381,
0.019682733342051506,
0.021386267617344856,
0.003413562197238207,
0.007406376302242279,
-0.015777816995978355,
-0.06170045956969261,
-0.00739692896604538,
0.0... |
PMID:25665 | Cell membrane enzymes: L-gamma-glutamyl transpeptidase, leucine aminopeptidase, maltase and trehalase in normal and leukaemic lymphocytes. | Several cell-membrane enzymes, which serve functions in amino acid and sugar transport, were measured in peripheral blood lymphocytes from chronic B and T lymphocytic disorders, blast cells in acute leukaemias, and in normal lymphocytes from cord blood, peripheral blood of adults, tonsils and bone-marrow plasma cells i... | Cell membrane enzymes: L-gamma-glutamyl transpeptidase, leucine aminopeptidase, maltase and trehalase in normal and leukaemic lymphocytes. Several cell-membrane enzymes, which serve functions in amino acid and sugar transport, were measured in peripheral blood lymphocytes from chronic B and T lymphocytic disorders, bla... | [
-0.020301273092627525,
-0.048295147716999054,
-0.038976315408945084,
0.027938684448599815,
-0.01934957504272461,
-0.06819790601730347,
0.11604900658130646,
0.06527117639780045,
-0.029509510844945908,
-0.05912117287516594,
0.03477731719613075,
-0.031256455928087234,
0.009105922654271126,
0.... |
PMID:25666 | Characterization of marrow granulocyte development: enzyme-specific activity profiles in response to inflammatory reactions. | Isopycnic sedimentation has been used to separate granulocytes of varying stages of maturity from the bone marrows of normal rabbits and rabbits stimulated to undergo an intense inflammatory response. The separated cell populations were in turn utilized to study the specific activities of six intracellular enzymes. The... | Characterization of marrow granulocyte development: enzyme-specific activity profiles in response to inflammatory reactions. Isopycnic sedimentation has been used to separate granulocytes of varying stages of maturity from the bone marrows of normal rabbits and rabbits stimulated to undergo an intense inflammatory resp... | [
-0.038925059139728546,
-0.013423364609479904,
0.004885742906481028,
0.008441001176834106,
-0.024867940694093704,
0.005411320365965366,
0.03348340466618538,
0.0671062245965004,
-0.03384599834680557,
-0.008806326426565647,
0.047981999814510345,
-0.037710096687078476,
-0.019796455278992653,
0... |
PMID:25668 | Fluorescence-quenching study of glucose binding by yeast hexokinase isoenzymes. | A study of the effect of varying ionic strength on the glucose-induced quenching of tryptophan fluorescence of hexokinase isoenzymes A(P-I) and B(P-II) was carried out at pH 8.3 and pH 5.5. At p/ 8.3 both isoenzymes gave apparently linear Scatchard-type data plots even with protein concentrations and ionic strengths fo... | Fluorescence-quenching study of glucose binding by yeast hexokinase isoenzymes. A study of the effect of varying ionic strength on the glucose-induced quenching of tryptophan fluorescence of hexokinase isoenzymes A(P-I) and B(P-II) was carried out at pH 8.3 and pH 5.5. At p/ 8.3 both isoenzymes gave apparently linear S... | [
-0.08174460381269455,
0.005414898507297039,
-0.01933121681213379,
0.026282919570803642,
0.004787700716406107,
0.03287457302212715,
0.07987383008003235,
0.01981990784406662,
-0.020110592246055603,
-0.006743558216840029,
-0.023923911154270172,
-0.05626155436038971,
-0.02635171078145504,
0.05... |
PMID:25670 | Use of salicylic acid to measure the apparent intracellular pH in the Ehrlich ascites-tumor cell and Escherichia coli. | The distribution of salicylic acid between the intracellular and extracellular phases has been used to estimate the intracellular pH in the Ehrlich cell and Escherichia coli. The validity of the method was established by: (i) comparison of the results obtained with salicylic acid with those obtained with 5,5-dimethylox... | Use of salicylic acid to measure the apparent intracellular pH in the Ehrlich ascites-tumor cell and Escherichia coli. The distribution of salicylic acid between the intracellular and extracellular phases has been used to estimate the intracellular pH in the Ehrlich cell and Escherichia coli. The validity of the method... | [
-0.060567568987607956,
-0.05099719390273094,
0.008441372774541378,
-0.018890466541051865,
0.047952793538570404,
0.0027212491258978844,
0.0841439962387085,
0.0374905951321125,
0.001488167094066739,
0.002822591457515955,
0.050407774746418,
-0.0833006501197815,
0.010789096355438232,
-0.045838... |
PMID:25674 | Complexes of cobalt (II) and manganese (II) with adenosine 5'-diphosphate and adenosine 5'-triphosphate. A circular dichroism study. | For studies of interactions between Co2+ and adenosine 5'-diphosphate or adenosine 5'-triphosphate (ADPH4+ and ATPH5+ in strongly acidic medium) visible circular dichroism (d-d transitions of Co2+) and ultraviolet circular dichroism (adenine transitions) have proven to be very sensitive to structural changes. Drastic v... | Complexes of cobalt (II) and manganese (II) with adenosine 5'-diphosphate and adenosine 5'-triphosphate. A circular dichroism study. For studies of interactions between Co2+ and adenosine 5'-diphosphate or adenosine 5'-triphosphate (ADPH4+ and ATPH5+ in strongly acidic medium) visible circular dichroism (d-d transition... | [
-0.09817410260438919,
0.006262415088713169,
-0.0034497014712542295,
0.04225098341703415,
0.022185422480106354,
-0.03865237534046173,
0.0635906234383583,
0.013022348284721375,
-0.057915378361940384,
-0.06867578625679016,
0.11500893533229828,
-0.04545822739601135,
-0.019977020099759102,
0.02... |
PMID:25671 | [Reaction between polycytidylic acid and guanosine-5'-triphosphate at neural pH]. | The effect of changing the solution acidity in the interval of pH 7--8 on complex formation between polycytidilyc acid (polyC) and guanosine-5'-triphosphate (GTP) has been studied by the equilibrium dialysis and hydrogen ion titration methods. It is shown that in 1 M NaCl at 3 degrees C the complex stoichiometry underg... | [Reaction between polycytidylic acid and guanosine-5'-triphosphate at neural pH]. The effect of changing the solution acidity in the interval of pH 7--8 on complex formation between polycytidilyc acid (polyC) and guanosine-5'-triphosphate (GTP) has been studied by the equilibrium dialysis and hydrogen ion titration met... | [
-0.09907825291156769,
-0.039589736610651016,
0.013584451749920845,
0.019611721858382225,
-0.005902270786464214,
0.02496993914246559,
0.040762465447187424,
0.01963614672422409,
-0.014645620249211788,
-0.006446346640586853,
0.08535988628864288,
-0.06694842129945755,
0.030368974432349205,
0.0... |
PMID:25675 | Nonenzymatic hydrolysis reactions of adenosine 5'-triphosphate and its related compounds. III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis. | Trichlorodiethylenetriaminecobalt (III), [CoCl3dien], which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic mode, accelerated effectively and specifically hydrolysis of ATP to ADP and Pi. A kinetic study of the reaction indicated that the rate of hydrolysis was first o... | Nonenzymatic hydrolysis reactions of adenosine 5'-triphosphate and its related compounds. III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis. Trichlorodiethylenetriaminecobalt (III), [CoCl3dien], which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic... | [
-0.09780115634202957,
0.0322083905339241,
-0.0034089318942278624,
0.03674307093024254,
0.009462988935410976,
-0.09259267896413803,
0.028487317264080048,
0.02611975558102131,
-0.031093169003725052,
-0.006114219781011343,
0.0727713331580162,
-0.04448987916111946,
-0.07476408034563065,
-0.028... |
PMID:25672 | [Coupled transport of K+, Cl-, H+ and OH- ions in a liposome suspension]. | By means of the system of ion-selective electrodes the coupling transport of K+, H+ and Cl- ions in liposome suspension was studied. Nigericin and tributyl tin (TBT) were used as inductors of cation and anion exchange. Effect of pH gradient created on the membrane on ionic transport was studied. The latter was shown to... | [Coupled transport of K+, Cl-, H+ and OH- ions in a liposome suspension]. By means of the system of ion-selective electrodes the coupling transport of K+, H+ and Cl- ions in liposome suspension was studied. Nigericin and tributyl tin (TBT) were used as inductors of cation and anion exchange. Effect of pH gradient creat... | [
-0.06683681160211563,
-0.003764112712815404,
-0.006388351321220398,
0.03938206657767296,
0.034926608204841614,
-0.046164896339178085,
0.06220674887299538,
0.02011891081929207,
-0.04323311150074005,
-0.04432949796319008,
-0.014506571926176548,
-0.0874648168683052,
0.0032026355620473623,
0.0... |
PMID:25676 | Stacking interactions between aromatic amino acids and adenine ring of ATP in zinc mediated ternary complexes. | Spectrophotometric studies have provided evidence for zinc-mediated ternary complexes between ATP and aromatic amino acids. The hypochromicity observed in the 260 nm band of ATP increased in the order phenylalanine less than tyrosine less than tryptophan. Adding alanine did not produce any change of the ATP spectrum. T... | Stacking interactions between aromatic amino acids and adenine ring of ATP in zinc mediated ternary complexes. Spectrophotometric studies have provided evidence for zinc-mediated ternary complexes between ATP and aromatic amino acids. The hypochromicity observed in the 260 nm band of ATP increased in the order phenylal... | [
-0.12848913669586182,
0.04124902933835983,
-0.05643464997410774,
-0.0027659775223582983,
-0.03129516541957855,
0.00046483936603181064,
0.05573292449116707,
0.015156704932451248,
-0.06298500299453735,
-0.039146553725004196,
0.05750375613570213,
-0.03000446781516075,
-0.002217973815277219,
0... |
PMID:25673 | [Neuron membrane depolarization under the influence of cyclic-3',5'-adenosine monophosphate and its possible role in the neuronal molecular computer (MC)]. | The separate fourth intracellular microelectrode was used for controlling the conditions of cyclic nucleotide injection in neurons of Helix pomatia. Ionoforetic increase in intracellular cyclic AMP concentration elicits membrane depolarization in many neurons. Phosphodiesterase inhibitors 3-isobutyl-1-methylxantine and... | [Neuron membrane depolarization under the influence of cyclic-3',5'-adenosine monophosphate and its possible role in the neuronal molecular computer (MC)]. The separate fourth intracellular microelectrode was used for controlling the conditions of cyclic nucleotide injection in neurons of Helix pomatia. Ionoforetic inc... | [
-0.033140432089567184,
0.016551481559872627,
0.007768094539642334,
-0.046014584600925446,
-0.032962631434202194,
-0.0010833750711753964,
0.0529291145503521,
0.0374063141644001,
-0.03922037407755852,
-0.006961433682590723,
0.0665774792432785,
-0.06723950058221817,
0.031087495386600494,
-0.0... |
PMID:25678 | [Activity of gamma-glutamyl transferase of sheep cerebral cortex with respect to amino acids and glutathione]. | gamma-glutamyl Transferase fron Sheep brain cortex capillaries was studied from the point of view of transport of aminoacids across blood brain barrier. Excess substrate inhibition was competitive and observed both with donor (glutathione) and various acceptors (methionine, alanine, tryptophan) but not with arginine. E... | [Activity of gamma-glutamyl transferase of sheep cerebral cortex with respect to amino acids and glutathione]. gamma-glutamyl Transferase fron Sheep brain cortex capillaries was studied from the point of view of transport of aminoacids across blood brain barrier. Excess substrate inhibition was competitive and observed... | [
-0.04317276179790497,
-0.05592431500554085,
-0.06038661301136017,
0.03901470825076103,
0.008367919363081455,
0.01375474315136671,
0.0809125304222107,
-0.017385395243763924,
-0.01361834816634655,
-0.027405420318245888,
0.014555905014276505,
-0.06933283805847168,
0.033585820347070694,
0.0539... |
PMID:25679 | [Glutamate dehydrogenases of unicellular green algae: effects of nitrate and ammonium in vivo]. | The constitution and control by the inorganic nitrogen source of glutamate dehydrogenases of some unicellular green algae have been studied. The Ankistrodesmus braunii and Scenedesmus obliquus cells contain two different glutamate dehydrogenases, one of which is NADP-specific, the other is active with both NAD and NADP... | [Glutamate dehydrogenases of unicellular green algae: effects of nitrate and ammonium in vivo]. The constitution and control by the inorganic nitrogen source of glutamate dehydrogenases of some unicellular green algae have been studied. The Ankistrodesmus braunii and Scenedesmus obliquus cells contain two different glu... | [
-0.03894564509391785,
-0.02882036566734314,
-0.00668288441374898,
0.008397428318858147,
0.04388831555843353,
0.019672729074954987,
0.0017655242700129747,
-0.0004129871667828411,
-0.05802813917398453,
-0.02661975286900997,
0.047575898468494415,
-0.06227048113942146,
0.04400627315044403,
-0.... |
PMID:25680 | [Role of pyruvate kinase in non-specific changes of carbon photosynthetic metabolism, caused by the photophosphorylation inhibition]. | The decrease in the level of NADP reduction in chloroplasts under injections of cofactors of pseudocyclic FMN photophosphorylation (vitamin K3 and methylviologen) into pea, tomato and cucumber leaves resulted in the decrease of 14CO2 autotrophic accumulation rate and in the change of distribution of assimilated carbon ... | [Role of pyruvate kinase in non-specific changes of carbon photosynthetic metabolism, caused by the photophosphorylation inhibition]. The decrease in the level of NADP reduction in chloroplasts under injections of cofactors of pseudocyclic FMN photophosphorylation (vitamin K3 and methylviologen) into pea, tomato and cu... | [
-0.020003752782940865,
-0.013817571103572845,
-0.014813815243542194,
0.021359307691454887,
0.07792654633522034,
-0.044717490673065186,
0.012258711270987988,
-0.023252571001648903,
-0.0862593799829483,
-0.0028112849686294794,
0.08358516544103622,
-0.07784054428339005,
0.0199408121407032,
0.... |
PMID:25681 | [Accessibility of sulfhydryl groups to 5,5'-dithiobis-2-nitrobenzoic acid and acid-base properties of bovine and walleye pollock rhodopsin preparations]. | Both the number of exposed SH-groups and the rate of reaction with 5,5'dithiobis-2-nitrobenzoic acid (DTNB) in walleye pollock and bovine rhodopsin depend on a degree of native structure of the preparation to be investigated. The preparations studied can be arranged in the order of increase of these parameters as follo... | [Accessibility of sulfhydryl groups to 5,5'-dithiobis-2-nitrobenzoic acid and acid-base properties of bovine and walleye pollock rhodopsin preparations]. Both the number of exposed SH-groups and the rate of reaction with 5,5'dithiobis-2-nitrobenzoic acid (DTNB) in walleye pollock and bovine rhodopsin depend on a degree... | [
-0.06400793045759201,
-0.015653502196073532,
-0.049104832112789154,
0.015790093690156937,
0.01839081570506096,
-0.016242528334259987,
0.020493807271122932,
0.030264854431152344,
-0.053546227514743805,
-0.009074865840375423,
0.021085621789097786,
-0.10443494468927383,
0.02375846914947033,
0... |
PMID:25682 | Magnetic circular dichroism studies of myoglobin, hemoglobin and peroxidase at room and low temperatures. Ferrous high spin derivatives. | The magnetic circular dichroism spectra (MCD) recorded for the visible and near-UV regions of high-spin ferrous derivatives of myoglobin, hemoglobin, hemoglobin dimers and isolated chains as well as of horseradish peroxidase at pH 6.8 and 11.4 have been compared at the room and liquid nitrogen temperatures. The MCD of ... | Magnetic circular dichroism studies of myoglobin, hemoglobin and peroxidase at room and low temperatures. Ferrous high spin derivatives. The magnetic circular dichroism spectra (MCD) recorded for the visible and near-UV regions of high-spin ferrous derivatives of myoglobin, hemoglobin, hemoglobin dimers and isolated ch... | [
-0.12263278663158417,
0.061752799898386,
-0.0236460343003273,
0.006754815578460693,
0.055395569652318954,
-0.012063881382346153,
0.06759027391672134,
0.04814464598894119,
-0.020281456410884857,
-0.011869929730892181,
0.03929591551423073,
-0.03737037256360054,
-0.005026211496442556,
-0.0052... |
PMID:25683 | Immobilization of Streptomyces flavochromogenes pullulanase on tannic acid and TEAE--cellulose. | Pullulanase was immobilized successfully by simple, inexpensive methods that may be useful for industrial application of this enzyme. A tannin--pullulanase(TP) complex was obtained by addition of tannic acid to the culture filtrate of thermophilic Streptomyces flavochromogenes. TP could be bound to TEAE--cellulose (TTC... | Immobilization of Streptomyces flavochromogenes pullulanase on tannic acid and TEAE--cellulose. Pullulanase was immobilized successfully by simple, inexpensive methods that may be useful for industrial application of this enzyme. A tannin--pullulanase(TP) complex was obtained by addition of tannic acid to the culture f... | [
-0.07340890914201736,
0.002788121346384287,
-0.022565152496099472,
-0.019292835146188736,
0.013978960923850536,
-0.035191453993320465,
0.021137064322829247,
0.030248641967773438,
-0.053634028881788254,
0.008499708026647568,
-0.0007168979500420392,
-0.03325194492936134,
-0.022085070610046387,... |
PMID:25686 | Purinergic innervation of the guinea-pig urinary bladder. | 1 A number of criteria for considering adenosine 5'-triphosphate (ATP) as a neurotransmitter in the guinea-pig urinary bladder have been examined. In addition, the effect of tachyphylaxis to ATP on the response to non-adrenergic, non-cholinergic nerve stimulation has been re-examined.2 Quinacrine fluorescence histochem... | Purinergic innervation of the guinea-pig urinary bladder. 1 A number of criteria for considering adenosine 5'-triphosphate (ATP) as a neurotransmitter in the guinea-pig urinary bladder have been examined. In addition, the effect of tachyphylaxis to ATP on the response to non-adrenergic, non-cholinergic nerve stimulatio... | [
-0.00331110879778862,
-0.02156786061823368,
0.027814820408821106,
0.0026285352651029825,
-0.007858085446059704,
-0.0215618796646595,
0.05623430386185646,
0.03444673493504524,
-0.0011774447048082948,
-0.02042556367814541,
0.009816004894673824,
-0.07417196035385132,
-0.0388123020529747,
0.03... |
PMID:25687 | Inhibition of [3H]-dihydroalprenolol binding to rat cardiac membranes of various beta-blocking agents. | Binding of [3-H]-dihydroalprenolol ([3-H]-DHA) to rat cardiac membranes was rapid and reversible (k1 = 0.633-0.701 x 10(6) M(-1) S(-1) And k(-1) = 0.0017-0.0043 s(-1). 2 [3-H]-DHA bound to a single class of binding sites with an equilibrium dissociation constant (Kd25degreesc) of 5.7+/-1.1 x 10(-9) M. 3 This binding wa... | Inhibition of [3H]-dihydroalprenolol binding to rat cardiac membranes of various beta-blocking agents. Binding of [3-H]-dihydroalprenolol ([3-H]-DHA) to rat cardiac membranes was rapid and reversible (k1 = 0.633-0.701 x 10(6) M(-1) S(-1) And k(-1) = 0.0017-0.0043 s(-1). 2 [3-H]-DHA bound to a single class of binding si... | [
-0.08564373850822449,
-0.008585825562477112,
-0.038410287350416183,
0.02651108242571354,
0.0305267795920372,
-0.009085067547857761,
0.010667174123227596,
-0.013281431049108505,
-0.018636511638760567,
-0.0482955165207386,
-0.01611071079969406,
-0.05399000644683838,
-0.0066078160889446735,
0... |
PMID:25692 | Glycine high affinity uptake and strychnine binding associated with glycine receptors in the frog central nervous system. | Accumulation of [3H]glycine into synaptosomal fractions occurs by high affinity systems in cerebral cortex, optic tectum, brain stem and spinal cord of the frog. Specific [3H]strychnine binding which appears associated with postsynaptic glycine receptors is also demonstrable in these regions. By contrast, only very low... | Glycine high affinity uptake and strychnine binding associated with glycine receptors in the frog central nervous system. Accumulation of [3H]glycine into synaptosomal fractions occurs by high affinity systems in cerebral cortex, optic tectum, brain stem and spinal cord of the frog. Specific [3H]strychnine binding whic... | [
-0.04169951751828194,
-0.02506025694310665,
-0.04376770928502083,
-0.02310052327811718,
-0.038923125714063644,
0.0078058065846562386,
0.09187798947095871,
0.027555102482438087,
0.014450698159635067,
-0.001971200108528137,
0.05809762328863144,
-0.07687927782535553,
0.0388893187046051,
0.067... |
PMID:25696 | The effect of castration, thyroidectomy and haloperidol upon the turnover rates of dopamine and norepinephrine and the kinetic properties of tyrosine hydroxylase in discrete hypothalamic nuclei of the male rat. | Adult male rats were either castrated, thyroidectomized, or treated with haloperidol and the rates of turnover of dopamine (DA) and norepinephrine (NE) in the median eminence (ME), the arcuate and dorsomedial nuclei of the hypothalamus were estimated from the rate of decay of DA and NE concentrations as determined by r... | The effect of castration, thyroidectomy and haloperidol upon the turnover rates of dopamine and norepinephrine and the kinetic properties of tyrosine hydroxylase in discrete hypothalamic nuclei of the male rat. Adult male rats were either castrated, thyroidectomized, or treated with haloperidol and the rates of turnove... | [
-0.000001913383357532439,
-0.0002779003989417106,
0.007994492538273335,
-0.00040281505789607763,
-0.032347556203603745,
0.04040145128965378,
0.05713212862610817,
0.016994081437587738,
-0.020512718707323074,
-0.05550752952694893,
0.038456737995147705,
-0.041586101055145264,
0.0052351104095578... |
PMID:25697 | Pharmacologic responses of cells of a neuroblastoma X glioma hybrid clone and modulation of synapses between hybrid cells and mouse myotubes. | Cells of the hybrid clone NG108-15 responded to 5-hydroxytryptamine (5-HT), dopamine or acetylcholine with graded depolarizations involving membrane conductance increases. Responses desensitized during continuous application of the neurotransmitters, and responses to 5-HT and dopamine cross-desensitized: a desensitizin... | Pharmacologic responses of cells of a neuroblastoma X glioma hybrid clone and modulation of synapses between hybrid cells and mouse myotubes. Cells of the hybrid clone NG108-15 responded to 5-hydroxytryptamine (5-HT), dopamine or acetylcholine with graded depolarizations involving membrane conductance increases. Respon... | [
-0.034061770886182785,
-0.033583782613277435,
0.006692041642963886,
-0.021277936175465584,
-0.04079829156398773,
-0.01968444138765335,
0.07128150761127472,
0.047005705535411835,
-0.02493559755384922,
-0.06747365742921829,
0.073720283806324,
0.005742186680436134,
0.011746112257242203,
0.035... |
PMID:25699 | A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformation. | A thermodynamic analysis of the precipitation of amorphous calcium phosphate (ACP) and its transformation to crystalline apatite had been made. A nearly constant ion product, over a wide variety of conditions, was obtained for a tricalcium phosphate (TCP)-like phase suggesting that the molecular unit which governs the ... | A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformation. A thermodynamic analysis of the precipitation of amorphous calcium phosphate (ACP) and its transformation to crystalline apatite had been made. A nearly constant ion product, over a wide variety of conditions, was obtained for a ... | [
-0.07707251608371735,
-0.010534480214118958,
0.03653151914477348,
-0.026353007182478905,
-0.05202323943376541,
-0.029194237664341927,
0.02444097027182579,
0.02365831658244133,
-0.05739197880029678,
0.001221213024109602,
0.04879609867930412,
-0.09461015462875366,
0.011598513461649418,
0.030... |
PMID:25701 | Complement activating factor(s) of Trypanosoma lewisi: some physiochemical characteristics of the active components. | Of the complement activating factors present in Trypanosoma lewisi, the major component, a carbohydrate containing substance was further investigated. This component was found to have a lag time of complete activation of 2 CH50 units of bovine complement of approximately 15 minutes while 1% trypsin (a known activator o... | Complement activating factor(s) of Trypanosoma lewisi: some physiochemical characteristics of the active components. Of the complement activating factors present in Trypanosoma lewisi, the major component, a carbohydrate containing substance was further investigated. This component was found to have a lag time of compl... | [
-0.08736197650432587,
0.01762216165661812,
0.017282333225011826,
0.023235386237502098,
0.028021730482578278,
0.00819132849574089,
0.1633373647928238,
0.049230124801397324,
-0.07084354758262634,
-0.007697074208408594,
-0.02078951895236969,
-0.07200037688016891,
-0.05902935937047005,
0.00174... |
PMID:25702 | Blood flow in rabbit eyes after keratectomy and corneal transplantation. | We used radio-labelled microspheres to study the distribution of blood flow in different regions of rabbit eyes with inflamed corneas resulting from trauma or allograft reaction. The blood flow in the cornea, the anterior uvea and the regional lymph nodes draining it was increased, but total flow in the eye did not inc... | Blood flow in rabbit eyes after keratectomy and corneal transplantation. We used radio-labelled microspheres to study the distribution of blood flow in different regions of rabbit eyes with inflamed corneas resulting from trauma or allograft reaction. The blood flow in the cornea, the anterior uvea and the regional lym... | [
0.006771239917725325,
-0.07223059982061386,
-0.007939689792692661,
0.0572328194975853,
0.05046527832746506,
0.017974218353629112,
0.11822666972875595,
0.061478860676288605,
-0.06517786532640457,
0.039377424865961075,
-0.007585379295051098,
-0.060388535261154175,
-0.04041152074933052,
-0.02... |
PMID:25703 | Phosphate metabolism in blue-green bacteria. V. Factors affecting phosphate uptake in Plectonema boryanum. | Plectonema boryanum requires approximately 5 days of exposure to a culture medium lacking phosphorus to induce the "polyphosphate overplus" phenomenon. At pH9, phosphate uptake is greatest both from normal culture medium and from dilute salt solutions. Phosphate uptake from dilute salt solutions was greatest when Na+ o... | Phosphate metabolism in blue-green bacteria. V. Factors affecting phosphate uptake in Plectonema boryanum. Plectonema boryanum requires approximately 5 days of exposure to a culture medium lacking phosphorus to induce the "polyphosphate overplus" phenomenon. At pH9, phosphate uptake is greatest both from normal culture... | [
-0.024292999878525734,
0.006306810304522514,
0.012346295639872551,
-0.02674250863492489,
0.04593636095523834,
-0.0704454556107521,
0.029364319518208504,
0.03159511461853981,
-0.05780262500047684,
-0.00972413457930088,
0.03435298800468445,
-0.09332551062107086,
0.05154775083065033,
-0.02029... |
PMID:25704 | Effect of osmotic potential, pH, and temperature on the growth of a helical, motile mycoplasma causing corn stunt disease. | Growth characteristics of corn stunt spiroplasma, a helical, motile mycoplasma, were studied over a range of osmolality, pH, and temperature in a simple medium containing 20% (v/v) agamma horse serum, 1.5% (w/v) PPLO broth, and various concentrations of sucrose. The spiroplasma was able to grow in a wide spectrum of os... | Effect of osmotic potential, pH, and temperature on the growth of a helical, motile mycoplasma causing corn stunt disease. Growth characteristics of corn stunt spiroplasma, a helical, motile mycoplasma, were studied over a range of osmolality, pH, and temperature in a simple medium containing 20% (v/v) agamma horse ser... | [
-0.047398898750543594,
-0.01528489775955677,
0.07365968823432922,
-0.009674858301877975,
0.04364786669611931,
-0.0411735475063324,
0.011639668606221676,
0.03135894984006882,
-0.06709010899066925,
0.02449190430343151,
0.04163168743252754,
-0.08951972424983978,
0.006430526729673147,
0.016004... |
PMID:25705 | Brain metabolism and arterial acid-base balance following bilateral carotid occlusion in normotensive and experimental hypertensive rats. | The effects of bilateral common carotid artery occlusion on brain metabolism and arterial acid-base balance were studied in normotensive and experimental renovascular hypertensive rats. One hour after carotid occlusion in hypertensive rats, supratentorial lactate increased to 383% and lactate-pyruvate ratio to 280% of ... | Brain metabolism and arterial acid-base balance following bilateral carotid occlusion in normotensive and experimental hypertensive rats. The effects of bilateral common carotid artery occlusion on brain metabolism and arterial acid-base balance were studied in normotensive and experimental renovascular hypertensive ra... | [
-0.05161038413643837,
-0.0016684560105204582,
-0.017246879637241364,
0.050464894622564316,
0.004583456087857485,
0.0039024301804602146,
0.0718846395611763,
0.03739850968122482,
-0.054446879774332047,
-0.014956933446228504,
0.036819491535425186,
-0.03961798921227455,
-0.015362869948148727,
... |
PMID:25706 | Cardiac pharmacology and cardiomyopathy in Friedreich's ataxia. | Friedreich's ataxia is almost always associated with a cardiomyopathy. The cardiomyopathy and its attendant cardiopulmonary sequelae is the usual cause of death in this disease. The author reviews the known pharmacology of the heart, particularly as it applies to hypertrophic cardiomyopathy. The important role played b... | Cardiac pharmacology and cardiomyopathy in Friedreich's ataxia. Friedreich's ataxia is almost always associated with a cardiomyopathy. The cardiomyopathy and its attendant cardiopulmonary sequelae is the usual cause of death in this disease. The author reviews the known pharmacology of the heart, particularly as it app... | [
-0.0033759456127882004,
-0.00972195714712143,
-0.02530745416879654,
0.051746491342782974,
-0.02176755666732788,
-0.003970284480601549,
0.05455084890127182,
0.03552404046058655,
-0.007057159207761288,
-0.08522674441337585,
0.014746556058526039,
-0.11939749121665955,
0.003506734734401107,
0.... |
PMID:25707 | Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties. | Tienilic acid--2,3-dichloro-4-(2-thienyl-carbonyl)phenoxyacetic acid--is a new diuretic with uricosuric properties. Nineteen patients with moderate arterial hypertension were treated for 5 consecutive weeks in a randomized fashion in a double-blind study with either tienilic acid or hydrochlorothiazide. Blood pressure ... | Treatment of arterial hypertension with tienilic acid, a new diuretic with uricosuric properties. Tienilic acid--2,3-dichloro-4-(2-thienyl-carbonyl)phenoxyacetic acid--is a new diuretic with uricosuric properties. Nineteen patients with moderate arterial hypertension were treated for 5 consecutive weeks in a randomized... | [
-0.04677809402346611,
0.016697075217962265,
-0.03611498326063156,
0.04029100760817528,
0.013325904496014118,
0.006629731506109238,
0.058458127081394196,
0.09719166159629822,
-0.03366836905479431,
-0.019503477960824966,
0.0539078563451767,
-0.07957495748996735,
0.04307321086525917,
-0.04460... |
PMID:25708 | Minor tranquillizers in somatic disorders. | Conclusive evidence of improved outcome due to adjunctive anxiolytic therapy in some somatic conditions is lacking. However, such therapy may facilitate patient management without being "curative". The resulting improved feeling of well-being may be of value in the management of gastrointestinal disorders, migraine and... | Minor tranquillizers in somatic disorders. Conclusive evidence of improved outcome due to adjunctive anxiolytic therapy in some somatic conditions is lacking. However, such therapy may facilitate patient management without being "curative". The resulting improved feeling of well-being may be of value in the management ... | [
-0.01471025962382555,
0.012364535592496395,
0.06545797735452652,
0.035975031554698944,
-0.007139227818697691,
-0.03924307972192764,
0.06935470551252365,
-0.006460313219577074,
-0.03081531450152397,
-0.06188421696424484,
0.0015323217958211899,
0.03872806951403618,
-0.004657132085412741,
0.0... |
PMID:25709 | Hormonal regulation and the effects of glucose on tyrosine aminotransferase activity in adult rat hepatocytes cultured on floating collagen membranes. | Adult rat parenchymal hepatocytes can be maintained in primary culture on floating collagen membranes of prolonged periods of time. In this system the enzyme tyrosine aminotransferase is induced by glucagon, (10(-6) to 10(-8) M) hydrocortisone (10(-5) to 10(-8) M), and cyclic adenosine 3':5'-monophosphate (cAMP) (10(-4... | Hormonal regulation and the effects of glucose on tyrosine aminotransferase activity in adult rat hepatocytes cultured on floating collagen membranes. Adult rat parenchymal hepatocytes can be maintained in primary culture on floating collagen membranes of prolonged periods of time. In this system the enzyme tyrosine am... | [
0.012005305849015713,
0.028545496985316277,
-0.026547299697995186,
0.06958289444446564,
-0.012211404740810394,
0.002934780204668641,
0.04748457297682762,
0.006159140728414059,
-0.03551773726940155,
-0.022988978773355484,
-0.006982693448662758,
-0.05891470983624458,
0.016673048958182335,
0.... |
PMID:25712 | Purification and some properties of Bacillus macerans cycloamylose (cyclodextrin) glucanotransferase. | Bacillus macerans cycloamylose (cyclodextrin) glucanotransferase (EC 2.4.1.19) was purified by the technique of starch adsorption and DEAE-cellulose column chromatography, and then crystallized from an ammonium sulfate solution containing mM calcium chloride. The crystals of the enzyme were rod-shaped and showed a sing... | Purification and some properties of Bacillus macerans cycloamylose (cyclodextrin) glucanotransferase. Bacillus macerans cycloamylose (cyclodextrin) glucanotransferase (EC 2.4.1.19) was purified by the technique of starch adsorption and DEAE-cellulose column chromatography, and then crystallized from an ammonium sulfate... | [
-0.054931364953517914,
-0.034792639315128326,
-0.0619778037071228,
-0.0188857764005661,
0.043133631348609924,
-0.13648833334445953,
0.0033681804779917,
0.04443887993693352,
-0.05923739820718765,
-0.013963598757982254,
0.03149772062897682,
-0.10085132718086243,
0.0012945373309776187,
-0.028... |
PMID:25714 | Evidence for the detrimental effect of adrenaline infused to healthy dogs in doses imitating spontaneous secretion after coronary occlusion. | We have previously shown that acute coronary occlusion in the dog is often accompanied by increased adrenaline release into the blood. In the present study the consequences of this humoral reaction were studied in anaesthetised healthy mongrel dogs subjected to adrenaline infusion administered at a rate relevant to spo... | Evidence for the detrimental effect of adrenaline infused to healthy dogs in doses imitating spontaneous secretion after coronary occlusion. We have previously shown that acute coronary occlusion in the dog is often accompanied by increased adrenaline release into the blood. In the present study the consequences of thi... | [
-0.049149200320243835,
-0.001601149677298963,
-0.0032128910534083843,
0.09012743830680847,
-0.00691854627802968,
-0.023196805268526077,
0.07000311464071274,
0.010129585862159729,
-0.025086967274546623,
-0.029724709689617157,
0.0033854537177830935,
-0.08377384394407272,
-0.01327982172369957,
... |
PMID:25715 | Locomotion and neuromuscular system of Aglantha digitale. | Aglantha digitale swims in two ways: a slow rhythmical swim typical of hydromedusae in general and a sudden rapid movement that appears to be an escape response. The swimming musculature is an extremely well developed striated circular muscle layer that possesses a sarcoplasmic reticulum. The nervous system of this spe... | Locomotion and neuromuscular system of Aglantha digitale. Aglantha digitale swims in two ways: a slow rhythmical swim typical of hydromedusae in general and a sudden rapid movement that appears to be an escape response. The swimming musculature is an extremely well developed striated circular muscle layer that possesse... | [
0.0019097968470305204,
-0.06096470728516579,
0.01610816828906536,
0.035887960344552994,
0.014801731333136559,
-0.03878960385918617,
0.012056475505232811,
-0.019941121339797974,
0.0005902868579141796,
0.0180931705981493,
0.01801099069416523,
-0.06414803862571716,
-0.037413883954286575,
-0.0... |
PMID:25719 | Takayasu's disease in twin sisters. Possible genetic factors. | Takayasu's disease is well-known for its characteristic clinical features and its elusive etiology. Recently, we encountered twin Japanese sisters, both of whom were diagnosed as having Takayasu's disease. The parents, two sisters, and one brother are healthy. Family history revealed the parents are first cousins. Anal... | Takayasu's disease in twin sisters. Possible genetic factors. Takayasu's disease is well-known for its characteristic clinical features and its elusive etiology. Recently, we encountered twin Japanese sisters, both of whom were diagnosed as having Takayasu's disease. The parents, two sisters, and one brother are health... | [
0.005506342276930809,
-0.004154874477535486,
-0.012778784148395061,
-0.005989330820739269,
-0.000273323297733441,
0.03344844654202461,
0.07576293498277664,
0.05492163076996803,
-0.03235483914613724,
-0.019997067749500275,
0.005748641677200794,
-0.0951865017414093,
0.03436742350459099,
-0.0... |
PMID:25720 | Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion. | Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes af... | Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion. Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patien... | [
-0.021998444572091103,
0.06974366307258606,
-0.014993513002991676,
0.09600599110126495,
-0.02843634970486164,
-0.03518098220229149,
0.053659066557884216,
0.014112351462244987,
0.0382070317864418,
-0.03693089634180069,
-0.02104037255048752,
-0.05588842183351517,
0.049702227115631104,
0.0097... |
PMID:25721 | Characteristics of the inhibition of serum alkaline phosphatase by theophylline. | 1. The effect of various parameters on the inhibition of alkaline phosphatase activity by theophylline was studied. The influence of pH is great, being optimum for a value of 9.4. The temperature and the magnesium ion concentration have no to low effect. 2. The nature of the substrate and the nature of the buffer in wh... | Characteristics of the inhibition of serum alkaline phosphatase by theophylline. 1. The effect of various parameters on the inhibition of alkaline phosphatase activity by theophylline was studied. The influence of pH is great, being optimum for a value of 9.4. The temperature and the magnesium ion concentration have no... | [
0.0022389439400285482,
0.02278502844274044,
-0.0029729879461228848,
0.0548134408891201,
0.011447111144661903,
-0.05836138501763344,
0.10288691520690918,
0.08399083465337753,
-0.07105395942926407,
-0.03766900673508644,
0.0049484954215586185,
-0.028679179027676582,
0.005722464062273502,
0.08... |
PMID:25722 | A stable blood product for pH-blood-gas quality control. | We describe how to prepare, store, and use a hemolyzed blood product for simultaneous pH, pCO2, and pO2 quality control. Tonometry of the blood product with two oxygen and two carbon dioxide concentrations resulted in consistent and reproducible values during 38 weeks. The resulting pH values were consistent and reprod... | A stable blood product for pH-blood-gas quality control. We describe how to prepare, store, and use a hemolyzed blood product for simultaneous pH, pCO2, and pO2 quality control. Tonometry of the blood product with two oxygen and two carbon dioxide concentrations resulted in consistent and reproducible values during 38 ... | [
-0.07985454797744751,
0.028464259579777718,
0.028533190488815308,
0.019598625600337982,
-0.04496050998568535,
-0.019584668800234795,
0.032972849905490875,
0.0021894166711717844,
-0.08039531111717224,
0.01957033947110176,
0.00937755685299635,
-0.06993339955806732,
-0.0001650894555496052,
0.... |
PMID:25723 | Simultaneous detection and quantitation of drugs commonly involved in self-administered overdoses. | The system described here is designed for ease of detection and quantitation of tricyclic antidepressants, benzodiazepines, and other tranquilizers now commonly found in self poisoning. An ether extract of serum is purified by acid transfer, back-extracted into ether, dried, and evaporated. The residue is run on a thin... | Simultaneous detection and quantitation of drugs commonly involved in self-administered overdoses. The system described here is designed for ease of detection and quantitation of tricyclic antidepressants, benzodiazepines, and other tranquilizers now commonly found in self poisoning. An ether extract of serum is purifi... | [
-0.051309529691934586,
0.028784066438674927,
-0.009332324378192425,
-0.010590536519885063,
0.050048694014549255,
-0.03252294659614563,
0.10141555219888687,
0.027615059167146683,
-0.020297160372138023,
-0.05732317268848419,
0.02240239456295967,
-0.04660317301750183,
0.02090541645884514,
-0.... |
PMID:25724 | Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 degrees C. | We report optimal conditions for assaying highly purified human lactate dehydrogenase isoenzymes with the lactate-to-pyruvate and pyruvate-to-lactate reactions, as they apply to human serum. Interconversion of results between reactions is not practicable. Measurements of lactate dehydrogenase in either reaction directi... | Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate-to-pyruvate and pyruvate-to-lactate reactions in human serum at 25, 30, and 37 degrees C. We report optimal conditions for assaying highly purified human lactate dehydrogenase isoenzymes with the lactate-to-pyruvate and pyruvate-to-lact... | [
-0.04149538278579712,
0.020953239873051643,
-0.025153398513793945,
0.0706503838300705,
0.01918233372271061,
-0.010319546796381474,
0.023008976131677628,
0.05516326427459717,
-0.03220437839627266,
-0.039779629558324814,
0.027860423550009727,
-0.10029058158397675,
-0.013388846069574356,
0.04... |
PMID:25726 | Liquid chromatographic determination of urinary dopamine and norepinephrine as fluorescamine derivatives. | Dopamine (DM) and norepinephrine (NE) with 3,4-dihydroxybenzylamine as internal standard in normal human urine were extracted with alumina, labeled with fluorescamine and determined fluorometrically by liquid chromatography. The method is simple and in the case of excretion of DM in urines of subjects receiving 1-dopa,... | Liquid chromatographic determination of urinary dopamine and norepinephrine as fluorescamine derivatives. Dopamine (DM) and norepinephrine (NE) with 3,4-dihydroxybenzylamine as internal standard in normal human urine were extracted with alumina, labeled with fluorescamine and determined fluorometrically by liquid chrom... | [
-0.024278486147522926,
-0.004089678172022104,
0.022992311045527458,
0.0435938760638237,
0.013701106421649456,
0.018886491656303406,
0.09170868247747421,
0.03608359768986702,
-0.028957027941942215,
-0.0654134452342987,
-0.01878388039767742,
-0.04704079031944275,
-0.026560936123132706,
0.042... |
PMID:25727 | Characterization of the acid beta-D-galactosidases from human urine. | Acid beta-D-galactosidases (EC 3.2.1.23) from human urine samples have been characterized using GM1-ganglioside, asialofetuin, and 4-MU-beta-D galactopyranoside. Sepharose 6-B column chromatography of crude urine supernatant fluids resolved three forms of acid beta-D-galactosidase activity with apparent molecular weigh... | Characterization of the acid beta-D-galactosidases from human urine. Acid beta-D-galactosidases (EC 3.2.1.23) from human urine samples have been characterized using GM1-ganglioside, asialofetuin, and 4-MU-beta-D galactopyranoside. Sepharose 6-B column chromatography of crude urine supernatant fluids resolved three form... | [
-0.06326638907194138,
-0.022779466584324837,
0.03224077820777893,
-0.013647462241351604,
0.020514927804470062,
-0.0015826864400878549,
0.0244489423930645,
0.06789373606443405,
-0.014011619612574577,
-0.034357260912656784,
0.07094945013523102,
-0.06408490985631943,
-0.04690340533852577,
0.0... |
PMID:25728 | Lipoprotein-X and diagnosis of cholestasis: comparison with other biochemical parameters and liver biopsy. | The presence or absence of histological signs of cholestasis (on the basis of liver specimens obtained by means of liver biopsy) was compared with total bilirubin, alkaline phosphatase, gamma-glutamyl transpeptidase, ornithine carbamoyltransferase, serum glutamic oxaloacetic transaminase levels and LP-X test in 157 pat... | Lipoprotein-X and diagnosis of cholestasis: comparison with other biochemical parameters and liver biopsy. The presence or absence of histological signs of cholestasis (on the basis of liver specimens obtained by means of liver biopsy) was compared with total bilirubin, alkaline phosphatase, gamma-glutamyl transpeptida... | [
0.023762503638863564,
0.004315339960157871,
0.026410752907395363,
0.027811385691165924,
0.021210962906479836,
-0.01503294799476862,
0.08170045167207718,
0.05265439301729202,
0.014903155155479908,
-0.007102935574948788,
-0.0064100706949830055,
-0.07176688313484192,
0.005854706279933453,
0.0... |
PMID:25729 | Studies on alkaline phosphatase isoenzymes in hepatic diseases. Relation to gamma-glutamyltransferase. | Isoenzymes of alkaline phosphatase (ALP) and total gamma-glutamyltransferase (gamma GT) have been studied in patients with increased total ALP. Fractionation of alkaline phosphatase yielded clinical information which could not be obtained by determination ALP and gamma GT alone. 1. There was a high degree of correlatio... | Studies on alkaline phosphatase isoenzymes in hepatic diseases. Relation to gamma-glutamyltransferase. Isoenzymes of alkaline phosphatase (ALP) and total gamma-glutamyltransferase (gamma GT) have been studied in patients with increased total ALP. Fractionation of alkaline phosphatase yielded clinical information which ... | [
-0.003043145639821887,
-0.005048790480941534,
0.02460435777902603,
0.028699761256575584,
-0.008786465041339397,
-0.05175301432609558,
0.05332920327782631,
0.06908818334341049,
-0.03085010126233101,
-0.024095503613352776,
0.012595608830451965,
-0.07811105251312256,
-0.025379128754138947,
0.... |
PMID:25730 | A new variant of methylmalonic acidemia-defective coenzyme-apoenzyme binding in cultured fibroblasts. | Cultured fibroblasts from a patient with methylmalonic acidemia, clinically responsive to vitamin B-12, were studied in vitro. Kinetic analysis revealed abnormal binding of the coenzyme, 5'-deoxyadenosylcobalamin, for its methylmalonyl-CoA carbonylmutase apoenzyme, i.e., KM of 3.8 X 10(-5) M versus control KM of 1.5 X ... | A new variant of methylmalonic acidemia-defective coenzyme-apoenzyme binding in cultured fibroblasts. Cultured fibroblasts from a patient with methylmalonic acidemia, clinically responsive to vitamin B-12, were studied in vitro. Kinetic analysis revealed abnormal binding of the coenzyme, 5'-deoxyadenosylcobalamin, for ... | [
-0.06413960456848145,
0.05253840982913971,
-0.014469053596258163,
0.01966933161020279,
0.002914653392508626,
-0.042876917868852615,
0.05023154616355896,
0.015241065993905067,
-0.022022945806384087,
-0.010651595890522003,
0.05731063336133957,
-0.08384446799755096,
0.02882237732410431,
0.031... |
PMID:25731 | Immunoreactive properties of anti-thyroglobulin autoantibodies isolated by affinity chromatography from human thyroiditis serum. | A Sepharose-coupled 19S human thyroglobulin has been used as an immunoadsorbent to isolate anti-thyroglobulin autoantibodies and to evaluate the antigen-antibody interactions. With the system proposed a high yield of active antibody molecules was obtained. It is possible to evaluate both the soluble and precipitating '... | Immunoreactive properties of anti-thyroglobulin autoantibodies isolated by affinity chromatography from human thyroiditis serum. A Sepharose-coupled 19S human thyroglobulin has been used as an immunoadsorbent to isolate anti-thyroglobulin autoantibodies and to evaluate the antigen-antibody interactions. With the system... | [
-0.08123600482940674,
0.055681440979242325,
-0.03912581875920296,
-0.00638231635093689,
0.004406857304275036,
-0.02101673185825348,
0.10352557897567749,
0.05889835208654404,
-0.10719267278909683,
-0.02669731341302395,
-0.018540523946285248,
-0.0665195882320404,
-0.013119122944772243,
-0.01... |
PMID:25732 | Increased biliary excretion of ouabain induced by bucolome in the rat. | 1. Following the intravenous injection of 3H-ouabain (0.4 or 0.6 mg/100 g body weight) the plasma concentration and biliary excretion of ouabain were compared for control male Wistar rats and rats given bucolome (BC, 1-cyclohexyl-5-n-butyl-2,4,6-trioxoperhydroxypyrimidine, 20 mg/100 g) 40 min before the ouabain injecti... | Increased biliary excretion of ouabain induced by bucolome in the rat. 1. Following the intravenous injection of 3H-ouabain (0.4 or 0.6 mg/100 g body weight) the plasma concentration and biliary excretion of ouabain were compared for control male Wistar rats and rats given bucolome (BC, 1-cyclohexyl-5-n-butyl-2,4,6-tri... | [
-0.04549935832619667,
-0.0402037650346756,
0.03219860419631004,
-0.047101039439439774,
0.023864978924393654,
-0.037989985197782516,
0.013120525516569614,
0.03153543546795845,
-0.031761981546878815,
-0.014514472335577011,
-0.02090022899210453,
-0.11770366132259369,
-0.027402859181165695,
-0... |
PMID:25745 | Bullous papular urticaria. | A bullous type of papular urticaria is seen commonly in Iraq. The eruption can be extensive, simulating some of the more serious bullous skin diseases. This paper describes the condition clinically and histologically. | Bullous papular urticaria. A bullous type of papular urticaria is seen commonly in Iraq. The eruption can be extensive, simulating some of the more serious bullous skin diseases. This paper describes the condition clinically and histologically. | [
0.07016508281230927,
0.004044025205075741,
0.028080591931939125,
0.06823846697807312,
0.056847769767045975,
-0.0222154688090086,
0.04148891195654869,
0.0004372595576569438,
-0.0259116031229496,
-0.03869204595685005,
0.020002784207463264,
-0.14119024574756622,
0.037067484110593796,
0.020008... |
PMID:25749 | Streptococcus pneumoniae isolates relatively insensitive to penicillin G recovered from patients in Switzerland. | The sensitivity to penicillin G of pneumococci isolated in Switzerland has been determined by the quantitative tube dilution method. 3 out of 100 strains were relatively insensitive to this antibiotic (minimum inhibitory concentration greater than 0.1 microgram/ml), thus confirming observations already made in other co... | Streptococcus pneumoniae isolates relatively insensitive to penicillin G recovered from patients in Switzerland. The sensitivity to penicillin G of pneumococci isolated in Switzerland has been determined by the quantitative tube dilution method. 3 out of 100 strains were relatively insensitive to this antibiotic (minim... | [
-0.00008293156861327589,
0.0018996625440195203,
-0.047220077365636826,
-0.05131570249795914,
0.07299066334962845,
-0.025614822283387184,
-0.017065297812223434,
0.04977177828550339,
-0.04409760609269142,
0.028369572013616562,
-0.02430102601647377,
-0.06308729946613312,
0.012530963867902756,
... |
PMID:25754 | [Surgery of pancreatic endocrine tumours in the German Federal Republic: results of a survey (author's transl)]. | Within a ten-year scan (1967-1976) 207 insulinomas, 50 gastrinomas, 8 Verner-Morrison tumors, 5 glucagonomas and 12 endocrine pancreatic tumours with associated MEA syndrome (multiple endocrine adenomatosis) were treated surgically at various university hospitals (information obtained by questionnaire). Half of the ins... | [Surgery of pancreatic endocrine tumours in the German Federal Republic: results of a survey (author's transl)]. Within a ten-year scan (1967-1976) 207 insulinomas, 50 gastrinomas, 8 Verner-Morrison tumors, 5 glucagonomas and 12 endocrine pancreatic tumours with associated MEA syndrome (multiple endocrine adenomatosis)... | [
0.011916615068912506,
-0.042102523148059845,
0.014666414819657803,
0.011640707962214947,
-0.04251536354422569,
0.026245402172207832,
0.02757192775607109,
0.048378460109233856,
-0.06968250870704651,
-0.0372028686106205,
-0.013534069992601871,
-0.07643678039312363,
0.01299255806952715,
0.009... |
PMID:25757 | Labetalol: a review of its pharmacology and therapeutic use in hypertension. | Labetalol is an orally active adrenoceptor blocking drug which is a competitive antagonist at both alpha- and beta-adrenoceptor sites. Its beta-blocking effects resemble those of propranolol, but its overall haemodynamic effects are akin to those of a comination of propranolol and an alpha-adrenoceptor blocking drugs s... | Labetalol: a review of its pharmacology and therapeutic use in hypertension. Labetalol is an orally active adrenoceptor blocking drug which is a competitive antagonist at both alpha- and beta-adrenoceptor sites. Its beta-blocking effects resemble those of propranolol, but its overall haemodynamic effects are akin to th... | [
-0.02602309174835682,
0.027100808918476105,
-0.008569469675421715,
0.04551450163125992,
-0.010556526482105255,
-0.024015992879867554,
0.027912460267543793,
0.038957834243774414,
-0.03675578534603119,
-0.06489574909210205,
0.013458367437124252,
-0.0053060282953083515,
-0.013992768712341785,
... |
PMID:25760 | [Tear resistance of laser-welded dental alloys]. | The investigation was undertaken to establish the place of lasers as tools in the dental technical laboratory. Tests were undertaken to study resistance to tears in laser welded dental metal alloys. (Degudent U, Degulor M of Fa. Degussa.) Availabel as laser apparatus were a cw Nd:YAG-laser (400 Watt capacity) and a pul... | [Tear resistance of laser-welded dental alloys]. The investigation was undertaken to establish the place of lasers as tools in the dental technical laboratory. Tests were undertaken to study resistance to tears in laser welded dental metal alloys. (Degudent U, Degulor M of Fa. Degussa.) Availabel as laser apparatus wer... | [
-0.07037876546382904,
0.02690376341342926,
0.04224296659231186,
0.05784470960497856,
0.04864297807216644,
0.01816289685666561,
0.0025794822722673416,
0.08469007164239883,
-0.07986301928758621,
-0.03660335764288902,
-0.05134072154760361,
-0.07612866163253784,
0.01749945618212223,
0.01009722... |
PMID:25762 | Effects of subanesthetic concentrations of enflurane on rat pregnancy and early development. | Anesthetic pollutants in the operating room have been implicated in producing spontaneous abortion in exposed personnel and congenital malformations among their offspring. To test the effects of trace concentrations of enflurane on pregnancy, rats were exposed to two levels (10.7 and 63.7 ppm) of the anesthetic for 8 h... | Effects of subanesthetic concentrations of enflurane on rat pregnancy and early development. Anesthetic pollutants in the operating room have been implicated in producing spontaneous abortion in exposed personnel and congenital malformations among their offspring. To test the effects of trace concentrations of enfluran... | [
0.0404006652534008,
-0.020301232114434242,
0.007250993978232145,
-0.0011617183918133378,
-0.03081740438938141,
0.04340583458542824,
0.01867022179067135,
0.029170509427785873,
-0.052434615790843964,
-0.01738802343606949,
-0.0428147092461586,
-0.005940613336861134,
0.02438054047524929,
0.090... |
PMID:25763 | Metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether. | A review on metabolism and toxicity of the fluorinated anesthetic agent, fluroxene, is presented. Fluroxene anesthesia is nontoxic to man but fatal to many experimental animals. The fluroxene molecule (2,2,2-trifluroethyl vinyl ether) is composed of two moieties; both are toxic as a result of their metabolism: the viny... | Metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether. A review on metabolism and toxicity of the fluorinated anesthetic agent, fluroxene, is presented. Fluroxene anesthesia is nontoxic to man but fatal to many experimental animals. The fluroxene molecule (2,2,2-trifluroethyl vinyl ether) is composed of two moiet... | [
-0.002983114682137966,
0.013498948886990547,
0.006532048340886831,
0.006830750964581966,
0.04315660521388054,
-0.020885741338133812,
0.03208504989743233,
0.018616998568177223,
-0.03441901132464409,
-0.05009268596768379,
-0.012055463157594204,
-0.06017402186989784,
0.04187971353530884,
-0.0... |
PMID:25764 | A case of spermatic arteriovenous anastomosis in the horse. | A large anastomosis of the spermatic artery and vein is described. This was found while surgically removing an abdominal testis. Before surgery the animal wanted to rear after exercise and could not stand on 3 legs for any length of time while being shod. This unusual behaviour disappeared after removal of the mass. Th... | A case of spermatic arteriovenous anastomosis in the horse. A large anastomosis of the spermatic artery and vein is described. This was found while surgically removing an abdominal testis. Before surgery the animal wanted to rear after exercise and could not stand on 3 legs for any length of time while being shod. This... | [
0.007548187393695116,
0.01489902101457119,
0.03252873197197914,
0.03854142501950264,
-0.029736008495092392,
0.028575638309121132,
0.03818020224571228,
0.06315004825592041,
0.021003667265176773,
0.012408007867634296,
-0.015755144879221916,
-0.044246647506952286,
0.014459976926445961,
0.0003... |
PMID:25765 | Studies on the purification and properties of a 6.8-S DNA polymerase activity found in calf-thymus DNA polymerase-alpha fraction. | The heterogeneity of calf thymus DNA polymerase-alpha has been further investigated. In particular, an enzyme (enzyme D) which exhibits higher activity on poly(dA) . (dT)10 (A:T = 20:1) compared with that on activated DNA, has been further purified and its properties compared with two other activities of the DNA polyme... | Studies on the purification and properties of a 6.8-S DNA polymerase activity found in calf-thymus DNA polymerase-alpha fraction. The heterogeneity of calf thymus DNA polymerase-alpha has been further investigated. In particular, an enzyme (enzyme D) which exhibits higher activity on poly(dA) . (dT)10 (A:T = 20:1) comp... | [
-0.051841553300619125,
-0.0013441226910799742,
-0.030376551672816277,
-0.039178479462862015,
0.020253794267773628,
-0.01795528084039688,
0.05641242489218712,
0.02985772117972374,
-0.006301669869571924,
-0.022389018908143044,
0.04132826626300812,
-0.053541816771030426,
-0.04826698452234268,
... |
PMID:25766 | Sulfate-mediated affinity chromatography on NADP+-Sepharose of glutamate dehydrogenase from halophilic bacteria and of glucose-6-phosphate dehydrogenase from Escherichia coli. | An improved synthesis of the 8-(6-aminohexyl)amino derivative of NADP+ is described for use in affinity chromatography. The binding of glutamate dehydrogenase isolated from halobacterium of the Dead Sea on a column of Sepharose linked to this NADP+ derivative could be drastically enhanced by addition of sulfate (1M) an... | Sulfate-mediated affinity chromatography on NADP+-Sepharose of glutamate dehydrogenase from halophilic bacteria and of glucose-6-phosphate dehydrogenase from Escherichia coli. An improved synthesis of the 8-(6-aminohexyl)amino derivative of NADP+ is described for use in affinity chromatography. The binding of glutamate... | [
-0.08012877404689789,
0.021977217867970467,
-0.034514203667640686,
-0.04118786007165909,
0.050837598741054535,
0.005444912705570459,
0.0377013236284256,
0.005306890234351158,
-0.04686617851257324,
-0.028441932052373886,
0.043622154742479324,
-0.06677945703268051,
0.02794739231467247,
-0.00... |
PMID:25768 | Affinity labelling of the estrogen binding site of glutamate dehydrogenase with iodoacetyldiethylstilbestrol. Selective alkylation of cysteine-89. | Iodoacetyldiethylstilbestrol was used as an affinity label to alkylate the estrogen binding site of bovine liver glutamate dehydrogenase. This reagent induced inactivation and alkylation of the enzyme. The non-alkylating analogues diethylstilbestrol and estradiol protected the enzyme towards alkylation. The apparent co... | Affinity labelling of the estrogen binding site of glutamate dehydrogenase with iodoacetyldiethylstilbestrol. Selective alkylation of cysteine-89. Iodoacetyldiethylstilbestrol was used as an affinity label to alkylate the estrogen binding site of bovine liver glutamate dehydrogenase. This reagent induced inactivation a... | [
-0.037804167717695236,
-0.005048356018960476,
-0.05975959822535515,
-0.021899042651057243,
0.042642299085855484,
-0.04163350164890289,
0.044563982635736465,
0.011633867397904396,
-0.03525611758232117,
-0.018799731507897377,
0.049748312681913376,
-0.03777950257062912,
0.03144916146993637,
0... |
PMID:25769 | Purification, biochemical and immunological characterisation of hexosaminidase A from variant AB of infantile GM2 gangliosidosis. | Variant AB of infantile GM2 gangliosidosis is a fatal disease leading invariably to death within the first few years of life, due to the excessive storage of the glycolipids GM2 and GA2 which occurs in the nervous tissue of the patient. Unlike other variants of this hereditary disease, where a deficiency of hexosaminid... | Purification, biochemical and immunological characterisation of hexosaminidase A from variant AB of infantile GM2 gangliosidosis. Variant AB of infantile GM2 gangliosidosis is a fatal disease leading invariably to death within the first few years of life, due to the excessive storage of the glycolipids GM2 and GA2 whic... | [
-0.03643546253442764,
-0.001367000862956047,
0.05355525016784668,
-0.01758057065308094,
-0.02118607424199581,
-0.01823466084897518,
0.053997334092855453,
0.04328695684671402,
-0.04950789734721184,
-0.04703140631318092,
0.005813912488520145,
-0.07974977046251297,
-0.011727169156074524,
0.02... |
PMID:25772 | Conversion of the active-site cysteine residue of papain into a dehydro-serine, a serine and a glycine residue. | Photolysis of papain which had been inhibited with 2-bromo-2',4'-dimethoxyacetophenone regenerated papain, but also formed [deltaSer25]-papain (i.e. papain in which the active-site cysteine residue 25 was replaced by dehydroserine) via the intermediate dehydrocysteine analogue, [deltaCys25]-papain. Reduction with sodiu... | Conversion of the active-site cysteine residue of papain into a dehydro-serine, a serine and a glycine residue. Photolysis of papain which had been inhibited with 2-bromo-2',4'-dimethoxyacetophenone regenerated papain, but also formed [deltaSer25]-papain (i.e. papain in which the active-site cysteine residue 25 was rep... | [
-0.10043590515851974,
0.012681336142122746,
-0.05849527567625046,
0.0326593741774559,
0.04813271388411522,
-0.024807080626487732,
0.04499910771846771,
0.027297277003526688,
-0.002655556658282876,
0.03872692957520485,
0.0032342432532459497,
-0.08748253434896469,
0.05378735810518265,
0.01211... |
PMID:25775 | Bovine lenticular gamma-glutamylcysteine synthetase: reaction sequence. | The sequence of substrate addition and product release during the reaction catalyzed by gamma-glutamylcysteine synthetase was investigated with purified enzyme from bovine lens. Thermal inactivation and kinetic studies suggest that L-glutamate is the first substrate to bind to the enzyme. L-beta-Chloroalanine was used ... | Bovine lenticular gamma-glutamylcysteine synthetase: reaction sequence. The sequence of substrate addition and product release during the reaction catalyzed by gamma-glutamylcysteine synthetase was investigated with purified enzyme from bovine lens. Thermal inactivation and kinetic studies suggest that L-glutamate is t... | [
-0.023622440174221992,
-0.002039110055193305,
-0.045544520020484924,
-0.005801516119390726,
0.0359564945101738,
-0.011663920246064663,
0.05016894266009331,
0.01637558452785015,
-0.021133650094270706,
0.023745013400912285,
0.03777581825852394,
-0.04066119343042374,
0.029602553695440292,
0.0... |
PMID:25777 | Acid-base and gas tension of cerebrospinal fluid in Nigerians and tetanus patients. | The acid-base balance and gas tension of the cerebrospinal fluid of eight tetanus patients and twelve control subjects were studied. Tetanus patients had metabolic acidosis which was severely reflected in the cerebrospinal fluid. While the cerebrospinal fluid pH is lower than that of the arterial blood there was no dif... | Acid-base and gas tension of cerebrospinal fluid in Nigerians and tetanus patients. The acid-base balance and gas tension of the cerebrospinal fluid of eight tetanus patients and twelve control subjects were studied. Tetanus patients had metabolic acidosis which was severely reflected in the cerebrospinal fluid. While ... | [
-0.013033874332904816,
0.04950927942991257,
0.02209584228694439,
0.03382250294089317,
0.005044023972004652,
-0.011284859851002693,
0.07103380560874939,
0.07632217556238174,
-0.010856364853680134,
-0.025248028337955475,
0.005481085740029812,
-0.10209767520427704,
-0.06526099890470505,
0.038... |
PMID:25778 | Stereoselective interaction of tetrahydroisoquinolines in beta-adrenoceptor systems. | In selected beta1- (heart, lipolysis) and beta2-adrenoceptor (trachea) systems, the interaction of racemic-trimetoquinol (TMQ) and the erythro- and threo-diastereomers of 1-(3',4',5'-trimethoxy-alpha-hydroxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (alpha-hydroxy TMQ) was investigated. Each tetrahydroisoquin... | Stereoselective interaction of tetrahydroisoquinolines in beta-adrenoceptor systems. In selected beta1- (heart, lipolysis) and beta2-adrenoceptor (trachea) systems, the interaction of racemic-trimetoquinol (TMQ) and the erythro- and threo-diastereomers of 1-(3',4',5'-trimethoxy-alpha-hydroxybenzyl)-6,7-dihydroxy-1,2,3,... | [
-0.07910662144422531,
0.009998357854783535,
-0.03204178437590599,
0.0550282783806324,
-0.0391925685107708,
0.020426476374268532,
0.020180292427539825,
0.028241796419024467,
-0.0277415681630373,
-0.029141228646039963,
0.02263740450143814,
-0.036012422293424606,
-0.009668118320405483,
-0.019... |
PMID:25779 | Effect of progesterone on adrenoceptors in the isthmus of the rabbit oviduct. | The effect of adrenergic agonists on the contractility of circular muscle of the isthmus of the oviduct was studied in isolated tissues from rabbits in estrus and after progesterone pretreatment. alpha-Adrenoceptor sensitivity was not altered by progesterone, and the order of potencies of alpha-agonists was similar to ... | Effect of progesterone on adrenoceptors in the isthmus of the rabbit oviduct. The effect of adrenergic agonists on the contractility of circular muscle of the isthmus of the oviduct was studied in isolated tissues from rabbits in estrus and after progesterone pretreatment. alpha-Adrenoceptor sensitivity was not altered... | [
-0.004715449642390013,
-0.04526643082499504,
0.03524952009320259,
0.059207234531641006,
0.051783353090286255,
-0.007065503392368555,
0.032489512115716934,
0.0299703199416399,
-0.032399632036685944,
-0.02713467925786972,
-0.00013526182738132775,
-0.024882931262254715,
-0.029255198314785957,
... |
PMID:25782 | Does cytoplasmic alkalinization trigger mitochondrial energy dissipation in the brown adipocyte? | Indirect calorimetry measurements showed that brown fat thermogenesis was very sensitive to modifications of intra-cellular pH induced by extracellular acid-base perturbations. Specific blockage of active Na-K transport by ouabain inhibited the thermogenic response only in acidosis and more efficiently when the glycosi... | Does cytoplasmic alkalinization trigger mitochondrial energy dissipation in the brown adipocyte? Indirect calorimetry measurements showed that brown fat thermogenesis was very sensitive to modifications of intra-cellular pH induced by extracellular acid-base perturbations. Specific blockage of active Na-K transport by ... | [
-0.06272579729557037,
-0.02728261612355709,
0.009608901105821133,
0.056175414472818375,
0.05187036842107773,
0.0005994600360281765,
0.025361565873026848,
-0.0008272802806459367,
-0.019575415179133415,
-0.04653768613934517,
0.030404072254896164,
-0.09895925223827362,
-0.041838448494672775,
... |
PMID:25783 | Control of non-shivering thermogenesis in a hibernator. | Present experiments indicate that in hedgehogs two different control mechanisms of non-shivering thermogenesis (NST) exist. During arousal from hibernation catecholamines control heat production in the interscapular brown adipose tissue. In a non-hibernating state, cold-induced NST is controlled by a desoxycorticostero... | Control of non-shivering thermogenesis in a hibernator. Present experiments indicate that in hedgehogs two different control mechanisms of non-shivering thermogenesis (NST) exist. During arousal from hibernation catecholamines control heat production in the interscapular brown adipose tissue. In a non-hibernating state... | [
-0.03007800690829754,
0.027439242228865623,
-0.007752131670713425,
0.053333841264247894,
0.019664708524942398,
0.0003145307709928602,
0.053717002272605896,
0.03218577802181244,
-0.02413475140929222,
-0.022543039172887802,
0.019202010706067085,
-0.06745754182338715,
0.021147804334759712,
0.... |
PMID:25784 | The "second messenger" system in brown adipose tissue of developing rats. Its molecular composition and mechanism of function. | Our studies of the hormonal receptor system and of the sequence of enzymatic events interconnecting the initial hormonal stimulus to the brown adipocyte with its final subcellular effect are summarized here. The hormone-mediated regulatory pathway consists of the adenyl cyclase and the protein kinase systems; the forme... | The "second messenger" system in brown adipose tissue of developing rats. Its molecular composition and mechanism of function. Our studies of the hormonal receptor system and of the sequence of enzymatic events interconnecting the initial hormonal stimulus to the brown adipocyte with its final subcellular effect are su... | [
-0.038342710584402084,
-0.06129861995577812,
-0.04544435441493988,
-0.018921472132205963,
0.016509175300598145,
0.006592453457415104,
0.054978836327791214,
0.026265038177371025,
-0.03142273426055908,
-0.014626783318817616,
0.05540767312049866,
-0.09787895530462265,
0.0033379842061549425,
0... |
PMID:25790 | [Analysis of the mechanism of action of carbonic acid on tissue chemoreceptors]. | Perfusion of the small intestine of anesthetized cats with a solution imitating metabolic acidosis (pH = 7.3; [HCO-3] = =20.2 mM; PCO2 = 38 mm Hg) produced a threshold reflex increase in the blood pressure. The subsequent decrease of [HCO-3] to 3.2 mM and pH to 6.5 evoked a gradual raise of the blood pressure followed ... | [Analysis of the mechanism of action of carbonic acid on tissue chemoreceptors]. Perfusion of the small intestine of anesthetized cats with a solution imitating metabolic acidosis (pH = 7.3; [HCO-3] = =20.2 mM; PCO2 = 38 mm Hg) produced a threshold reflex increase in the blood pressure. The subsequent decrease of [HCO-... | [
-0.05307195335626602,
0.018052125349640846,
-0.00642551900818944,
0.04080117493867874,
0.008261743932962418,
-0.04145272448658943,
0.08995310962200165,
0.033042360097169876,
-0.01958927884697914,
-0.008427433669567108,
0.029206153005361557,
-0.06092136725783348,
-0.012115079909563065,
0.06... |
PMID:25791 | [Excretory function of the kidney after denervation and the administration of a beta-blockader]. | Osmotic diuresis (15% mannitol, 4.5 ml/hr) was in duced in anesthetized rats. At the end of each of 10 consecutive 10-min clearance periods the following parameters were determined: diuresis, sodium, chlorine and osmotic excretion, GFR (inulin clearance). The animals were divided into three groups: a) controls, b) with... | [Excretory function of the kidney after denervation and the administration of a beta-blockader]. Osmotic diuresis (15% mannitol, 4.5 ml/hr) was in duced in anesthetized rats. At the end of each of 10 consecutive 10-min clearance periods the following parameters were determined: diuresis, sodium, chlorine and osmotic ex... | [
-0.037527307868003845,
-0.03714044392108917,
0.044853270053863525,
-0.024098170921206474,
0.043656062334775925,
-0.030463680624961853,
0.07645848393440247,
0.023679861798882484,
-0.028300704434514046,
-0.05579192563891411,
-0.046848397701978683,
-0.09146751463413239,
0.03860720992088318,
0... |
PMID:25799 | Rapid assays of urinary estriol in pregnant women. | Two devices designed for rapid assay of urinary estriol, the E3 KIT and E3 HAIR KIT, were evaluated using urine samples taken from pregnant women. Additionally, the clinical application of these devices in pregnancy management was examined. Correlations were high between an established method and the E3 KIT method (r =... | Rapid assays of urinary estriol in pregnant women. Two devices designed for rapid assay of urinary estriol, the E3 KIT and E3 HAIR KIT, were evaluated using urine samples taken from pregnant women. Additionally, the clinical application of these devices in pregnancy management was examined. Correlations were high betwe... | [
-0.01600414328277111,
0.019245633855462074,
0.01603851467370987,
0.0047131991013884544,
0.06269708275794983,
0.015350354835391045,
0.01282938290387392,
0.033400699496269226,
-0.04098303243517876,
0.004615257028490305,
0.004667801316827536,
-0.02129966951906681,
0.018666135147213936,
-0.020... |
PMID:25800 | Total serum cholesterol, triglycerides and phospholipids during the normal menstrual cycle. | Ten healthy women (mean age, 29 years) with regular menstrual cycles of 26 to 29 days were tested for levels of total serum cholesterol, triglycerides, phospholipids, and estradiol three times during one menstrual cycle-during menstruation, at ovulation, and in the luteal phase. All studies were performed simultaneousl... | Total serum cholesterol, triglycerides and phospholipids during the normal menstrual cycle. Ten healthy women (mean age, 29 years) with regular menstrual cycles of 26 to 29 days were tested for levels of total serum cholesterol, triglycerides, phospholipids, and estradiol three times during one menstrual cycle-during m... | [
0.029000604525208473,
0.03400876373052597,
-0.028450340032577515,
-0.007190206553786993,
0.018485933542251587,
-0.026960810646414757,
0.01130653265863657,
0.035927124321460724,
-0.026665424928069115,
-0.07918532192707062,
0.010681528598070145,
-0.06487841159105301,
0.05481737479567528,
-0.... |
PMID:25801 | Toxoplasma antibodies and spontaneous abortion. | One hundred and fifty-two women with spontaneous abortion were investigated by hemagglutination (HA) and immunofluorescence antibody (IFA) tests for toxoplasmosis. In 48 cases, quantitive immunoglobulin (Ig) studies and mouse inoculation with gestational material were performed. Positive toxoplasma antibody titers were... | Toxoplasma antibodies and spontaneous abortion. One hundred and fifty-two women with spontaneous abortion were investigated by hemagglutination (HA) and immunofluorescence antibody (IFA) tests for toxoplasmosis. In 48 cases, quantitive immunoglobulin (Ig) studies and mouse inoculation with gestational material were per... | [
-0.03132069110870361,
-0.03443748503923416,
-0.024313636124134064,
0.023002758622169495,
0.005024858750402927,
-0.013564066030085087,
0.07242342084646225,
0.10138026624917984,
-0.046015746891498566,
-0.018859030678868294,
-0.020396454259753227,
-0.04766179621219635,
-0.04085758328437805,
0... |
PMID:25802 | Training: an integral adjunct to the introduction of newer methods of fertility regulation. | The provision of new technologies of fertility control that are known to be safer, simpler, and more effective may at first result in higher complication rates, particularly if training in the new techniques is inadequate. This was illustrated by analysis of data on several fertility control methods collected by the In... | Training: an integral adjunct to the introduction of newer methods of fertility regulation. The provision of new technologies of fertility control that are known to be safer, simpler, and more effective may at first result in higher complication rates, particularly if training in the new techniques is inadequate. This ... | [
-0.01107818353921175,
0.02408522553741932,
0.022272378206253052,
0.025354208424687386,
0.050346456468105316,
0.02363731898367405,
-0.017204588279128075,
0.05216222628951073,
-0.028841523453593254,
-0.023885300382971764,
0.0015024689491838217,
-0.021192358806729317,
0.005331453401595354,
0.... |
PMID:25803 | Laparoscopy for the confirmation and prognostic evaluation of pelvic inflammatory disease. | A presumptive diagnosis of pelvic inflammatory disease (PID) is usually made in our gynecologic clinics when obscure, acute lower abdominal pain is accompained by fever and abnormal vaginal discharge, urinary and rectal discomfort, marked tenderness of the pelvic organs to palpation, or pelvic masses. In the present st... | Laparoscopy for the confirmation and prognostic evaluation of pelvic inflammatory disease. A presumptive diagnosis of pelvic inflammatory disease (PID) is usually made in our gynecologic clinics when obscure, acute lower abdominal pain is accompained by fever and abnormal vaginal discharge, urinary and rectal discomfor... | [
0.02013343758881092,
-0.02336246892809868,
0.018092256039381027,
0.028207071125507355,
-0.00041042620432563126,
0.0076231202110648155,
0.06975362449884415,
0.07774326205253601,
0.023229211568832397,
0.02750016748905182,
0.0052841538563370705,
-0.06750845164060593,
0.025643208995461464,
-0.... |
PMID:25804 | Difficult obstetric vesicovaginal fistula: a report on 12 cases. | In each of the 12 cases presented, the fistula was the result of obstructed labor. Common features to each case were: (a) a large retropubic defect involving the anterior vaginal wall, bladder and urethra, (b) total or partial urethral rupture, and (c) marked vaginal wall scarring with vaginal stenosis. Primary repair ... | Difficult obstetric vesicovaginal fistula: a report on 12 cases. In each of the 12 cases presented, the fistula was the result of obstructed labor. Common features to each case were: (a) a large retropubic defect involving the anterior vaginal wall, bladder and urethra, (b) total or partial urethral rupture, and (c) ma... | [
0.016541484743356705,
-0.03067130036652088,
-0.003822456579655409,
0.05842018499970436,
-0.046361327171325684,
-0.0005515003576874733,
-0.011131590232253075,
0.05569504573941231,
-0.016716789454221725,
0.018486114218831062,
-0.05831589549779892,
-0.08995417505502701,
-0.0055872309021651745,
... |
PMID:25805 | The successful treatment of a case of primary sterility resulting from Fredrickson's Type V hyperlipemia and panhypopituitarism. | Successful treatment of primary sterility in a woman having the rare association of panhypopituitarism with Fredrickson's Type V hyperlipemia is described. Replacement therapy with l-thyroxine, prednisone and a low fat diet cleared the patient's blood of the excessive chylomicrons and very low density lipoproteins. Ovu... | The successful treatment of a case of primary sterility resulting from Fredrickson's Type V hyperlipemia and panhypopituitarism. Successful treatment of primary sterility in a woman having the rare association of panhypopituitarism with Fredrickson's Type V hyperlipemia is described. Replacement therapy with l-thyroxin... | [
-0.006952038966119289,
0.03859104961156845,
-0.033105283975601196,
0.03493085503578186,
0.022983616217970848,
-0.009355931542813778,
0.03365516662597656,
0.06910889595746994,
-0.03455950319766998,
-0.038764145225286484,
-0.023236021399497986,
-0.06843172758817673,
0.04669489711523056,
0.01... |
PMID:25806 | Progesterone metabolism in cultured amniotic fluid cells. | Amniotic fluid cells obtained by amnicentesis at 16-20 weeks' gestation were grown in culture until a confluent monolayer of cell had been formed. Radiolabeled pregnenolone, progesterone and 20 alpha-dihydroprogesterone were added to the cell cultures; steroid metabolites which formed after 24 and 48 hours of incubatio... | Progesterone metabolism in cultured amniotic fluid cells. Amniotic fluid cells obtained by amnicentesis at 16-20 weeks' gestation were grown in culture until a confluent monolayer of cell had been formed. Radiolabeled pregnenolone, progesterone and 20 alpha-dihydroprogesterone were added to the cell cultures; steroid m... | [
-0.02435801737010479,
0.02755623869597912,
-0.05736751854419708,
-0.015534499660134315,
0.019470037892460823,
0.008684552274644375,
-0.03924175351858139,
0.0392787791788578,
-0.03642238304018974,
-0.00761465122923255,
-0.004325665067881346,
-0.034522827714681625,
0.004191127605736256,
0.01... |
PMID:25807 | Clostridial sepsis after abortion with PGF2alpha and intracervical laminaria tents--a case report. | A case of clostridial endomyometritis and sepsis necessitating total abdominal hysterectomy which occurred 12 hours following abortion induced with intraamniotic administration of prostaglandin F2 alpha and laminaria tent insertion is discussed. Cultures from cervical, blood, and surgical specimens all yielded Clostrid... | Clostridial sepsis after abortion with PGF2alpha and intracervical laminaria tents--a case report. A case of clostridial endomyometritis and sepsis necessitating total abdominal hysterectomy which occurred 12 hours following abortion induced with intraamniotic administration of prostaglandin F2 alpha and laminaria tent... | [
0.02332865074276924,
0.02279333770275116,
-0.05272754281759262,
0.043690744787454605,
0.02424774505198002,
-0.01299776416271925,
-0.012823889963328838,
0.06573603302240372,
-0.004954845644533634,
-0.013264792971313,
-0.014112329110503197,
-0.05700886994600296,
0.0057634878903627396,
-0.007... |
PMID:25808 | Experience with minilaparotomy in the Philippines. | This paper presents the socio-demographic characteristics, medical histories, and clinical data on 651 women sterilized by interval minilaparotomy procedures in Manila, Philippines. About two thirds of the procedures were performed with local anesthesia; the Pomeroy technique was used for tubal ligation. In 2.8% of the... | Experience with minilaparotomy in the Philippines. This paper presents the socio-demographic characteristics, medical histories, and clinical data on 651 women sterilized by interval minilaparotomy procedures in Manila, Philippines. About two thirds of the procedures were performed with local anesthesia; the Pomeroy te... | [
0.023946207016706467,
-0.016797037795186043,
0.038154054433107376,
-0.019888145849108696,
0.0008277380838990211,
0.010702981613576412,
0.014210930094122887,
0.03324827924370766,
-0.03786275535821915,
0.013400949537754059,
-0.003956769127398729,
-0.04552451893687248,
0.0055496105924248695,
... |
PMID:25810 | The potential reduction of medical complications from induced abortion. | Reducing medical complications resulting from induced abortion by identifying the safest and most appropriate procedures(s) for each gestational age is the purpose of this study. Data on all women who had induced abortions at all hospitals in the State of Hawaii where such procedures were performed between March 11, 19... | The potential reduction of medical complications from induced abortion. Reducing medical complications resulting from induced abortion by identifying the safest and most appropriate procedures(s) for each gestational age is the purpose of this study. Data on all women who had induced abortions at all hospitals in the S... | [
-0.010223819874227047,
0.06102374196052551,
-0.012734394520521164,
0.009638468734920025,
0.030347533524036407,
0.021782953292131424,
0.006849008612334728,
0.08666547387838364,
-0.035777196288108826,
0.015199858695268631,
-0.01862384006381035,
0.014099274761974812,
-0.019611218944191933,
0.... |
PMID:25811 | Some demographic aspects of pregnancy histories of sterilized women in the Mission Hospitals of Karnataka. | This study deals with the pregnancy histories of 534 women whow were sterilized in the Mission Hospitals in Karnataka State (India) during 1974 and 1975. Fertility differentials prevailing in various sociocultural groups are indicated. The study highlights the prevalence of adolescent sterility and also emphasizes the ... | Some demographic aspects of pregnancy histories of sterilized women in the Mission Hospitals of Karnataka. This study deals with the pregnancy histories of 534 women whow were sterilized in the Mission Hospitals in Karnataka State (India) during 1974 and 1975. Fertility differentials prevailing in various sociocultural... | [
0.049468692392110825,
0.027163861319422722,
-0.05419989675283432,
0.004123243968933821,
0.028749264776706696,
0.06628542393445969,
-0.006141485180705786,
0.031130077317357063,
0.015318953432142735,
-0.005706681404262781,
-0.008782093413174152,
-0.04539375752210617,
0.010606274008750916,
0.... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.