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PMID:25813 | A new modification of colpocleisis for treatment of total procidentia in old age. | A new approach for treating uterine prolapse in old age is presented. Fiftten patients underwent this operation during our 5-year study. The procedure is simple and brief and can be performed, using a local anesthetic, on patients whose general condition is poor. The patients in our series had no immediate postoperativ... | A new modification of colpocleisis for treatment of total procidentia in old age. A new approach for treating uterine prolapse in old age is presented. Fiftten patients underwent this operation during our 5-year study. The procedure is simple and brief and can be performed, using a local anesthetic, on patients whose g... | [
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PMID:25814 | Study of "spontaneous" abortion in Thailand. | This analysis includes data on 3 530 patients with septic or incomplete, inevitable or threatened abortions who were treated at the Siriraj Hospital in Bangkok between January 1972 and December 1973. Data on the patients' socio-demographic characteristics; their reproductive, abortion, and medical histories; their pre-... | Study of "spontaneous" abortion in Thailand. This analysis includes data on 3 530 patients with septic or incomplete, inevitable or threatened abortions who were treated at the Siriraj Hospital in Bangkok between January 1972 and December 1973. Data on the patients' socio-demographic characteristics; their reproductive... | [
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PMID:25815 | The cold sterilization of abortion cannulae. | The purpose of this study was to determine if cold sterilization is a feasible method for sterilizing abortion cannulae and, if so, to find the appropriate solutions and time intervals for this sterilization process. Study findings show that abortion cannulae can be cold sterilized by soaking them for a minimum of 10 m... | The cold sterilization of abortion cannulae. The purpose of this study was to determine if cold sterilization is a feasible method for sterilizing abortion cannulae and, if so, to find the appropriate solutions and time intervals for this sterilization process. Study findings show that abortion cannulae can be cold ste... | [
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PMID:25816 | Extramembranous pregnancy: a case report. | A rare case of extramembranous pregnancy is reported. It was associated with intermittent loss of liquor and bloody discharge beginning at about the 25th week of gestation. An anencephalic infant was delivered alive from a breech presentation during the 31st week of gestation. The placenta was markedly circumvallate, w... | Extramembranous pregnancy: a case report. A rare case of extramembranous pregnancy is reported. It was associated with intermittent loss of liquor and bloody discharge beginning at about the 25th week of gestation. An anencephalic infant was delivered alive from a breech presentation during the 31st week of gestation. ... | [
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PMID:25820 | Management of acute anxiety syndrome with parenterally administered lorazepam. | After the preliminary successful use of injectable lorazepam in calming 20 patients who presented with acute anxiety crises, a formal study of 115 other such patients was carried out. All were seen either in a hospital emergency room or on an emergency out-patient basis in private practice. Treatment consisted of an in... | Management of acute anxiety syndrome with parenterally administered lorazepam. After the preliminary successful use of injectable lorazepam in calming 20 patients who presented with acute anxiety crises, a formal study of 115 other such patients was carried out. All were seen either in a hospital emergency room or on a... | [
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PMID:25824 | [Pregnancy and labor in twins. II. Determination of twin pregnancy and avoidance of premature birth (author's transl)]. | In about 65% of the 258 twin births which occurred at the University Gynaecological Hospital, Zürich, from 1966 to 1976, it was possible to diagnose the twin pregnancy before the birth of the first twin. Twin pregnancy could be diagnosed in 96.2% of all the cases before the birth of the first twin, after routine ultras... | [Pregnancy and labor in twins. II. Determination of twin pregnancy and avoidance of premature birth (author's transl)]. In about 65% of the 258 twin births which occurred at the University Gynaecological Hospital, Zürich, from 1966 to 1976, it was possible to diagnose the twin pregnancy before the birth of the first tw... | [
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PMID:25825 | [Study of H-2 mutations in mice. VII. The defectiveness of the H-2ba mutant in the hemagglutination and graft vs host reactions]. | Three mutants of the H-2K gene within the mouse major histocompatibility complex were studied. Antisera anti-H-2.5 + 39 were unable to agglutinate H-2ba and H-2bf mutant red blood cells. The same sera moderately agglutinated H-2b red blood cells. The H-2ba red blood cells did not absorb in vitro the activity from an an... | [Study of H-2 mutations in mice. VII. The defectiveness of the H-2ba mutant in the hemagglutination and graft vs host reactions]. Three mutants of the H-2K gene within the mouse major histocompatibility complex were studied. Antisera anti-H-2.5 + 39 were unable to agglutinate H-2ba and H-2bf mutant red blood cells. The... | [
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PMID:25826 | Vitamin D-3 intestinal absorption in vivo: influence of fatty acids, bile salts, and perfusate pH on absorption. | Intestinal absorption of vitamin D-3 in physiological concentrations was studied in the live unanesthetised rat. In both the jejunum and the ileum a linear relationship was found between the absorption rate of the vitamin and its intraluminal concentration. Increasing the sodium taurocholate concentation in the perfusa... | Vitamin D-3 intestinal absorption in vivo: influence of fatty acids, bile salts, and perfusate pH on absorption. Intestinal absorption of vitamin D-3 in physiological concentrations was studied in the live unanesthetised rat. In both the jejunum and the ileum a linear relationship was found between the absorption rate ... | [
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PMID:25827 | Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion. | We have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancreatic bicarbonate secretion (PBS) increased markedly and proximal duodenal pH decreased from 6.2 to 4.3. Portal and peripheral IRS concentrations... | Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion. We have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancrea... | [
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PMID:25828 | Pathophysiological responses to meals in the Zollinger-Ellison syndrome: I. Paradoxical postprandial inhibition of gastric secretion. | The gastric acid, pepsin, and secretory volume output in response to a mixed meal were measured in six patients with Zollinger-Ellison syndrome caused by a gastrin-producing tumour proved subsequently at surgery. The patients were all normocalcaemic, and none had previous abdominal surgery. In four of the six patients,... | Pathophysiological responses to meals in the Zollinger-Ellison syndrome: I. Paradoxical postprandial inhibition of gastric secretion. The gastric acid, pepsin, and secretory volume output in response to a mixed meal were measured in six patients with Zollinger-Ellison syndrome caused by a gastrin-producing tumour prove... | [
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PMID:25829 | Intestinal phase of gastric secretion in patients with duodenal ulcer. | In 10 healthy subjects and 10 duodenal ulcer patients the intestinal phase of gastric acid secretion was studied by intraduodenal infusion of a 10% liver extract meal (pH 7) at 400 ml/h for three hours. A gastroduodenal double lumen tube with two balloons was used to block the pylorus and to prevent duodenogastric refl... | Intestinal phase of gastric secretion in patients with duodenal ulcer. In 10 healthy subjects and 10 duodenal ulcer patients the intestinal phase of gastric acid secretion was studied by intraduodenal infusion of a 10% liver extract meal (pH 7) at 400 ml/h for three hours. A gastroduodenal double lumen tube with two ba... | [
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PMID:25830 | Induction of gastro-oesophageal reflux by alcohol. | In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a st... | Induction of gastro-oesophageal reflux by alcohol. In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH wa... | [
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PMID:25831 | 24-hour rhythms in uterine and umbilical blood flows of conscious pregnant sheep. | The possibility that 24-hour rhythms exist in uterine blood flow (UtBF) and umbilical blood (UmBF) was investigated in 5 days postoperative chronically instrumented near-term pregnant sheep acclimated to a controlled environment. UtBF, UmBF and pressure measurements were made at 15-min intervals over 24 h beginning at ... | 24-hour rhythms in uterine and umbilical blood flows of conscious pregnant sheep. The possibility that 24-hour rhythms exist in uterine blood flow (UtBF) and umbilical blood (UmBF) was investigated in 5 days postoperative chronically instrumented near-term pregnant sheep acclimated to a controlled environment. UtBF, Um... | [
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PMID:25832 | [The hypertensive effect of adyston and etilefrin. Comparative animal experimental studies]. | According to the results obtained under the described conditions it can be stated that after i.v. administration Adyston induces a dose-dependent rise in systolic and diastolic blood pressure, in comparison with etilefrin the new product Adyston shows a greater potency in rising the systolic and diastolic blood pressur... | [The hypertensive effect of adyston and etilefrin. Comparative animal experimental studies]. According to the results obtained under the described conditions it can be stated that after i.v. administration Adyston induces a dose-dependent rise in systolic and diastolic blood pressure, in comparison with etilefrin the n... | [
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PMID:25833 | [Treatment of parkinson's syndrome. New developments]. | The treatment of Parkinson's syndrome with newly developed drugs has to be planned within the entire therapeutic concept. Besides the anticholinergics, levodopa, amantadines and beta-blockers should be taken into consideration. When necessary, hypnotics, ataractics and antidepressant drugs should be applied. | [Treatment of parkinson's syndrome. New developments]. The treatment of Parkinson's syndrome with newly developed drugs has to be planned within the entire therapeutic concept. Besides the anticholinergics, levodopa, amantadines and beta-blockers should be taken into consideration. When necessary, hypnotics, ataractics... | [
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PMID:25834 | Insulin effect on proteolytic activities in rat skeletal muscle. | Proteolytic activity has been measure in rat skeletal muscle by use of [14C]-hemoglobin as substrate. The activity of the alkaline proteinases increases during starvation and in diabetic state. In streptozotocin-diabetic animals the activity of alkaline proteases increases to 300% over a time of 21 days. Insulin treatm... | Insulin effect on proteolytic activities in rat skeletal muscle. Proteolytic activity has been measure in rat skeletal muscle by use of [14C]-hemoglobin as substrate. The activity of the alkaline proteinases increases during starvation and in diabetic state. In streptozotocin-diabetic animals the activity of alkaline p... | [
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PMID:25835 | The effect of stress or glucose feeding on hepatic tyrosine aminotransferase activity and liver and plasma tyrosine level of intact and adrenalectomized rats. | The increase of hepatic tyrosine aminotransferase and the fall of plasma tyrosine in rats subjected to immobilization is reconfirmed. Moreover, the same effects three hrs after exposuing the animals to 400 revolutions in Noble-Collip drums are described. However, in bilaterally adrenalectomized rats both hepatic tyrosi... | The effect of stress or glucose feeding on hepatic tyrosine aminotransferase activity and liver and plasma tyrosine level of intact and adrenalectomized rats. The increase of hepatic tyrosine aminotransferase and the fall of plasma tyrosine in rats subjected to immobilization is reconfirmed. Moreover, the same effects ... | [
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PMID:25836 | Liver cell heterogeneity. The distribution of fructose-bisphosphatase in fed and fasted rats and in man. | Periportal and perivenous hepatocytes were isolated by microdissection from lyophilized liver slices (16 micrometer) from fed and fasted rats and from a human patient. NADP/NADPH cycling was used to determine fructose-1,6-bisphosphatase activity in the isolated hepatocytes (10 ng dry weight). The periportal hepatocytes... | Liver cell heterogeneity. The distribution of fructose-bisphosphatase in fed and fasted rats and in man. Periportal and perivenous hepatocytes were isolated by microdissection from lyophilized liver slices (16 micrometer) from fed and fasted rats and from a human patient. NADP/NADPH cycling was used to determine fructo... | [
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PMID:25837 | Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver. | Aromatic-amino-acid-glyoxylate aminotransferase was highly purified from the mitochondrial fraction of livers from monkey and glucagon-injected rats. The two enzyme preparations showed physical and enzymic properties different from a kynurenine aminotransferase previously described. The two enzymes had nearly identical... | Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver. Aromatic-amino-acid-glyoxylate aminotransferase was highly purified from the mitochondrial fraction of livers from monkey and glucagon-injected rats. The two enzyme preparations showed physical and enzymic pr... | [
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PMID:25838 | Studies on the involvement of lysosomes in estrogen action, I. Isolation and enzymatic properties of pig endometrial lysosomes. | Pig endometrium cells, collected by curettage and homogenized in an all-glass Potter Elvehjem homogenizer, gave a considerably higher yield of intact mitochondria and lysosomes than homogenates of whole uterus obtained with the Ultraturrax or the Parr bomb. After homogenization of the cells and subfractionation in the ... | Studies on the involvement of lysosomes in estrogen action, I. Isolation and enzymatic properties of pig endometrial lysosomes. Pig endometrium cells, collected by curettage and homogenized in an all-glass Potter Elvehjem homogenizer, gave a considerably higher yield of intact mitochondria and lysosomes than homogenate... | [
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PMID:25845 | Bacteriological findings in the transtracheal aspirate from patients with acute exacerbation of chronic bronchitis. | Transtracheal aspirates from 87 patients with acute exacerbations of chronic bronchitis who had received no recent antibiotic treatment were examined. A single bacterial species was found in 83% of positive cultures. Predominant pathogens were Haemophilus influenzae and Streptococcus pneumoniae which occurred jointly o... | Bacteriological findings in the transtracheal aspirate from patients with acute exacerbation of chronic bronchitis. Transtracheal aspirates from 87 patients with acute exacerbations of chronic bronchitis who had received no recent antibiotic treatment were examined. A single bacterial species was found in 83% of positi... | [
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PMID:25847 | Antihypertensive effect of trimepranol, a new beta-blocking agent. | Trimepranol (TMP) is a new propranolol-like, non-selective beta-adrenoreceptor blocking drug. Its antihypertensive effect versus placebo was evaluated in a double-blind corss-over study in 25 ambulatory patients, whose supine diastolic blood pressure (BP) was at least 95 mm Hg. After four weeks treatment with placebo, ... | Antihypertensive effect of trimepranol, a new beta-blocking agent. Trimepranol (TMP) is a new propranolol-like, non-selective beta-adrenoreceptor blocking drug. Its antihypertensive effect versus placebo was evaluated in a double-blind corss-over study in 25 ambulatory patients, whose supine diastolic blood pressure (B... | [
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PMID:25851 | Ultrafiltration evidence of ion binding by macromolecules in urine. | In an effort to rationalize the difference between computed estimates of urinary calcium oxalate supersaturation and estimates obtained by equilibrating urine with solid calcium oxalate, we examined ultrasfiltered urine for the binding of urinary ions. Urine was passed through a filter with a nominal passage cutoff of ... | Ultrafiltration evidence of ion binding by macromolecules in urine. In an effort to rationalize the difference between computed estimates of urinary calcium oxalate supersaturation and estimates obtained by equilibrating urine with solid calcium oxalate, we examined ultrasfiltered urine for the binding of urinary ions.... | [
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PMID:25848 | A behavioral approach to post-catastrophic illness work phobias. | Two patients developed work phobias following major catastrophic physical illness. A combined approach to addressing their specific fears of returning to premorbid levels of work function utilized deep muscle relaxation, imagery based desensitization, social reinforcement, and shaping techniques. A significant increase... | A behavioral approach to post-catastrophic illness work phobias. Two patients developed work phobias following major catastrophic physical illness. A combined approach to addressing their specific fears of returning to premorbid levels of work function utilized deep muscle relaxation, imagery based desensitization, soc... | [
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PMID:25852 | Oxalate transport by the human small intestine. | Oxalate was transported in vitro by intestinal brush border cells from rabbit and human by a non-energy-dependent diffusion mechanism. An oxalate-binding protein that had an approximate molecular weight of 73,000 was identified in the human intestine (ileum), was localized in the cytosol cell fraction, and was affected... | Oxalate transport by the human small intestine. Oxalate was transported in vitro by intestinal brush border cells from rabbit and human by a non-energy-dependent diffusion mechanism. An oxalate-binding protein that had an approximate molecular weight of 73,000 was identified in the human intestine (ileum), was localize... | [
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PMID:25856 | A quantitative cytochemical method for measuring carbonic anhydrase activity. | Components of a histochemical method for demonstrating carbonic anhydrase activity have been investigated quantitatively. It was found that it is not necessary to use free-floating sections provided the reaction is done in a reaction medium of controlled depth. This permits the use of normal cryostat sections on glass ... | A quantitative cytochemical method for measuring carbonic anhydrase activity. Components of a histochemical method for demonstrating carbonic anhydrase activity have been investigated quantitatively. It was found that it is not necessary to use free-floating sections provided the reaction is done in a reaction medium o... | [
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PMID:25859 | Anemia as a stimulus to aortic and carotid chemoreceptors in the cat. | In cats anesthetized with alpha-chloralose, the activities of aortic and carotid chemoreceptor nerves were measured during a control period and during anemia where the hematocrit was lowered in steps by dextran-for-blood exchange. With anemia there was a sustained nonlinear increase in firing of aortic chemoreceptors. ... | Anemia as a stimulus to aortic and carotid chemoreceptors in the cat. In cats anesthetized with alpha-chloralose, the activities of aortic and carotid chemoreceptor nerves were measured during a control period and during anemia where the hematocrit was lowered in steps by dextran-for-blood exchange. With anemia there w... | [
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PMID:25860 | Analysis of postcapillary pH changes in blood in vivo after gas exchange. | A quantitative description of the reaction and transport processes that take place in blood during and after gas exchange in capillaries is developed and used to interpret recently reported experimental results. Included in the computation are 1) CO2-H2CO3 hydration-dehydration reactions in plasma and erythrocytes, 2) ... | Analysis of postcapillary pH changes in blood in vivo after gas exchange. A quantitative description of the reaction and transport processes that take place in blood during and after gas exchange in capillaries is developed and used to interpret recently reported experimental results. Included in the computation are 1)... | [
-0.06595655530691147,
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PMID:25875 | Neutral cleanup procedure for 2,3,7,8-tetrachlorodibenzo-p-dioxin residues in bovine fat and milk. | A neutral cleanup method for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in milk and animal tissue was developed involving solvent extraction and liquid adsorption chromatography on magnesia-Celite 545, alumina, and Florisil. Cleaned up extracts were subjected to dual-ion analysis in a direct probe high resolution mass ... | Neutral cleanup procedure for 2,3,7,8-tetrachlorodibenzo-p-dioxin residues in bovine fat and milk. A neutral cleanup method for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in milk and animal tissue was developed involving solvent extraction and liquid adsorption chromatography on magnesia-Celite 545, alumina, and Floris... | [
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PMID:25876 | Atomic absorption spectroscopic determination of lead extracted from acid-solubilized tissues. | A method is presented for determining lead in a variety of tissues. Lyophilized samples are solubilized with nitric acid at room temperature in glass screw-cap culture tubes. Following neutralization with sodium hydroxide and sodium bicarbonate, the lead is extracted into methyl isobutyl ketone as the pyrrolidine dithi... | Atomic absorption spectroscopic determination of lead extracted from acid-solubilized tissues. A method is presented for determining lead in a variety of tissues. Lyophilized samples are solubilized with nitric acid at room temperature in glass screw-cap culture tubes. Following neutralization with sodium hydroxide and... | [
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PMID:25877 | pH-induced difference spectrophotometric assay of acetazolamide, hydrochlorothiazide, and furosemide. | On the basis of pH-induced spectral changes for acetazolamide, hydrochlorothiazide, and furosemide, 3 different spectrophotometric methods are described. The methods were successfully applied to the assay of these drugs in different pharmaceutical formulations (tablets and ampoules). The accuracy of the analysis is inc... | pH-induced difference spectrophotometric assay of acetazolamide, hydrochlorothiazide, and furosemide. On the basis of pH-induced spectral changes for acetazolamide, hydrochlorothiazide, and furosemide, 3 different spectrophotometric methods are described. The methods were successfully applied to the assay of these drug... | [
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PMID:25878 | Purification and characterization of extracellular soluble and membrane-bound insoluble alkaline phosphatases possessing phosphodiesterase activities in Bacillus subtilis. | A membrane-bound insoluble alkaline phosphatase (APase) and an extracellular soluble APase were purified, respectively, from a membrane preparation of Bacillus subtilis 6160-BC6, which carries a mutation to produce APase constitutively, and from a culture fluid of a mutant strain. RAN 1, isolated from strain 6160-BC6, ... | Purification and characterization of extracellular soluble and membrane-bound insoluble alkaline phosphatases possessing phosphodiesterase activities in Bacillus subtilis. A membrane-bound insoluble alkaline phosphatase (APase) and an extracellular soluble APase were purified, respectively, from a membrane preparation ... | [
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PMID:25879 | Oxygen-limited continuous culture and respiratory energy conservation in Escherichia coli. | Escherichia coli B was cultured continuously in succinate-minimal medium under conditions of oxygen limitation in the phauxostat. With decreasing oxygenation and consequent decreasing growth rates, the complement of terminal cytochrome oxidases changed as follows: high growth rates, cytochrome o; intermediate growth ra... | Oxygen-limited continuous culture and respiratory energy conservation in Escherichia coli. Escherichia coli B was cultured continuously in succinate-minimal medium under conditions of oxygen limitation in the phauxostat. With decreasing oxygenation and consequent decreasing growth rates, the complement of terminal cyto... | [
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PMID:25880 | Assimilatory sulfate reduction in an Escherichia coli mutant lacking thioredoxin activity. | An investigation of sulfate reduction in B tsnC*7004, a mutant of Escherichia coli lacking thioredoxin, is reported. Although thioredoxin is indispensable for the adenosine 3'-phosphate 5'-phosphosulfate (PAPS) sulfotransferase reaction under the usual conditions of assay in extracts of wild-type cells, the mutant grew... | Assimilatory sulfate reduction in an Escherichia coli mutant lacking thioredoxin activity. An investigation of sulfate reduction in B tsnC*7004, a mutant of Escherichia coli lacking thioredoxin, is reported. Although thioredoxin is indispensable for the adenosine 3'-phosphate 5'-phosphosulfate (PAPS) sulfotransferase r... | [
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PMID:25881 | Identity of proline dehydrogenase and delta1-pyrroline-5-carboxylic acid reductase in Clostridium sporogenes. | Proline dehydrogenase and delta1-pyrroline-5-carboxylic acid (PCA) reductase activities were copurified 60- and 130-fold, respectively, from extracts of Clostridium sporogenes. The primary change in the ratio of activites was the result of a loss of proline dehydrogenase activity during dialysis. Both activities were e... | Identity of proline dehydrogenase and delta1-pyrroline-5-carboxylic acid reductase in Clostridium sporogenes. Proline dehydrogenase and delta1-pyrroline-5-carboxylic acid (PCA) reductase activities were copurified 60- and 130-fold, respectively, from extracts of Clostridium sporogenes. The primary change in the ratio o... | [
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PMID:25882 | Role of Na+ and Li+ in thiomethylgalactoside transport by the melibiose transport system of Escherichia coli. | Thiomethyl-beta-galactoside (TMG) accumulation via the melibiose transport system was studied in lactose transport-negative strains of Escherichia coli. TMG uptake by either intact cells or membrane vesicles was markedly stimulated by Na+ or Li+ between pH 5.5 and 8. The Km for uptake of TMG was approximately 0.2 mM at... | Role of Na+ and Li+ in thiomethylgalactoside transport by the melibiose transport system of Escherichia coli. Thiomethyl-beta-galactoside (TMG) accumulation via the melibiose transport system was studied in lactose transport-negative strains of Escherichia coli. TMG uptake by either intact cells or membrane vesicles wa... | [
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PMID:25883 | Purification and characterization of a secondary alcohol dehydrogenase from a pseudomonad. | Growth of Pseudomonas sp. NRRL B3266 in the presence of oleic acid resulted in the induction of two enzymes: oleate hydratase, which produced 10(R)hydroxyoctadecanoate, and hydroxyoctadecanoate dehydrogenase, which catalyzed the oxidized nicotinamide adenine dinucleotide-dependent production of 10-oxooctadecanoate. Thi... | Purification and characterization of a secondary alcohol dehydrogenase from a pseudomonad. Growth of Pseudomonas sp. NRRL B3266 in the presence of oleic acid resulted in the induction of two enzymes: oleate hydratase, which produced 10(R)hydroxyoctadecanoate, and hydroxyoctadecanoate dehydrogenase, which catalyzed the ... | [
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PMID:25884 | Purification and characterization of a hyaluronidase associated with a temperate bacteriophage of group A, type 49 streptococci. | Urea treatment of a temperate bacteriophage from a type 49 strain of group A streptococcus (Streptococcus pyogenes) followed by ammonium sulfate fractionation, ion exchange, and affinity chromatography of solubilized proteins provided for the recovery (12%) and purification (44-fold) of the phage-associated hyaluronida... | Purification and characterization of a hyaluronidase associated with a temperate bacteriophage of group A, type 49 streptococci. Urea treatment of a temperate bacteriophage from a type 49 strain of group A streptococcus (Streptococcus pyogenes) followed by ammonium sulfate fractionation, ion exchange, and affinity chro... | [
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PMID:25885 | Enolase from spores and cells of Bacillus megaterium: two-step purification of the enzyme and some of its properties. | A simple two-step procedure for purification of enolase from germinated spores or vegetative cells of Bacillus megaterium is described. The procedure resulted in a 1,200-fold purification with production of homogeneous enzyme in approximately 75% yield; the enzymes from spores and cells seemed identical. The molecular ... | Enolase from spores and cells of Bacillus megaterium: two-step purification of the enzyme and some of its properties. A simple two-step procedure for purification of enolase from germinated spores or vegetative cells of Bacillus megaterium is described. The procedure resulted in a 1,200-fold purification with productio... | [
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PMID:25886 | Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. | The specific beta-adrenergic agonist radioligand (+/-)-[3H]hydroxybenzylisoproterenol ([3H]HBI) was used to investigate alterations in the beta-adrenergic receptors of frog erythrocytes occurring during the process of agonist-induced, receptor-specific desensitization. There was close agreement between the percentage f... | Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. The specific beta-adrenergic agonist radioligand (+/-)-[3H]hydroxybenzylisoproterenol ([3H]HBI) was used to investigate alterations in the beta-adrenergic receptors of frog erythrocytes occurring during the process of... | [
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PMID:25887 | Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell. | Digitonin treatment of chick liver cells in monolayer culture perforates the plasma membrane, causing release of acetyl-CoA carboxylase and other cytosolic enzymes. The rate of carboxylase release is affected by conditions known to alter the position of the protomer-polymer (filament) equilibrium of the enzyme. Citrate... | Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell. Digitonin treatment of chick liver cells in monolayer culture perforates the plasma membrane, causing release of acetyl-CoA carboxylase and other cytosolic enzymes. The rate of carboxylase release is affected ... | [
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PMID:25889 | Hemoglobins of the killifish Fundulus heteroclitus. Separation, characterization, and a model for the subunit compositions. | Polyacrylamide and starch gel electrophoresis of the hemoglobin of the killifish Fundulus heteroclitus reveal the presence of four clearly distinguishable components. These isohemoglobins, each tetramers consisting of alpha and beta chains, can be preparatively separated by ion exchange chromatography on DEAE-cellulose... | Hemoglobins of the killifish Fundulus heteroclitus. Separation, characterization, and a model for the subunit compositions. Polyacrylamide and starch gel electrophoresis of the hemoglobin of the killifish Fundulus heteroclitus reveal the presence of four clearly distinguishable components. These isohemoglobins, each te... | [
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PMID:25890 | Hydrogen exchange kinetics of human hemoglobins. The pH dependence of solvent accessibility in cyanomet-, oxy-, and deoxyhemoglobin. | The hydrogen exchange kinetics of human oxy-, deoxy-, and cyanomethemoglobin have been measured as a function of pH by the tritium tracer method. At 5 degrees C and in phosphate buffer both liganded and unliganded forms of ferrohemoglobin exhibit deviations from the regular pH dependence of exchange that is characteris... | Hydrogen exchange kinetics of human hemoglobins. The pH dependence of solvent accessibility in cyanomet-, oxy-, and deoxyhemoglobin. The hydrogen exchange kinetics of human oxy-, deoxy-, and cyanomethemoglobin have been measured as a function of pH by the tritium tracer method. At 5 degrees C and in phosphate buffer bo... | [
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PMID:25891 | Enzymatic methylation of carboxyl groups of chromaffin granule membrane proteins. | Carboxyl groups of membrane and soluble proteins from bovine adrenal medulla chromaffin granules were enzymatically methylated. The methylated peptides were resolved using gel electrophoresis under acidic conditions in the presence of N-cetylpyridinium chloride. There was a selective methylation of two groups of membra... | Enzymatic methylation of carboxyl groups of chromaffin granule membrane proteins. Carboxyl groups of membrane and soluble proteins from bovine adrenal medulla chromaffin granules were enzymatically methylated. The methylated peptides were resolved using gel electrophoresis under acidic conditions in the presence of N-c... | [
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PMID:25894 | Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts. | An ultracentrifugation assay has been developed to measure low density lipoprotein (LDL) receptor activity in membranes prepared from cultured human fibroblasts. The binding site for 125I-labeled LDL in isolated membranes reflected the properties of the LDL receptor previously demonstrated in intact fibroblasts. It exh... | Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts. An ultracentrifugation assay has been developed to measure low density lipoprotein (LDL) receptor activity in membranes prepared from cultured human fibroblasts. The binding site for 125I-labeled LDL in isolated membr... | [
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PMID:25896 | Isolation and characterization of ornithine transcarbamylase from normal human liver. | We report experiments describing the isolation and characterization of ornithine transcarbamylase from normal human liver. Our preparative procedure employs initial centrifugation and heat steps, intermediate batch-wise adsorption and desorption from ion exchange resins and column chromatographic elution from hydroxyla... | Isolation and characterization of ornithine transcarbamylase from normal human liver. We report experiments describing the isolation and characterization of ornithine transcarbamylase from normal human liver. Our preparative procedure employs initial centrifugation and heat steps, intermediate batch-wise adsorption and... | [
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PMID:25898 | Changes in hepatic levels of tyrosine aminotransferase messenger RNA during induction by hydrocortisone. | Messenger RNA specific for tyrosine aminotransferase was quantitated by microinjection into oocytes of Xenopus laevis. The heterologously translated enzyme was identified by specific immunoprecipitation and found to be identical with authentic aminotransferase by several criteria. The level of functional message presen... | Changes in hepatic levels of tyrosine aminotransferase messenger RNA during induction by hydrocortisone. Messenger RNA specific for tyrosine aminotransferase was quantitated by microinjection into oocytes of Xenopus laevis. The heterologously translated enzyme was identified by specific immunoprecipitation and found to... | [
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PMID:25900 | Magnesium-induced inner membrane aggregation in heart mitochondria. | Mg(2+) at an optimal concentration of 2mM (ph 6.5) induces large increases (up to 30 percent) in the optical density of bovine heart mitochondria incubated under conditions of low ionic strength (< approx. 0.01). The increases are associated with aggregation (sticking together) of the inner membranes and are little ... | Magnesium-induced inner membrane aggregation in heart mitochondria. Mg(2+) at an optimal concentration of 2mM (ph 6.5) induces large increases (up to 30 percent) in the optical density of bovine heart mitochondria incubated under conditions of low ionic strength (< approx. 0.01). The increases are associated with ag... | [
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PMID:25901 | Polymerization of actin. IV. Role of Ca++ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm. | When Pisaster, Asterias, or Thyone sperm are treated with the ionophore A23187 or X537A, an acrosomal reaction similar but not identical to a normal acrosomal reaction is induced in all the sperm. Based upon the response of the sperm, the acrosomal reaction consists of a series of temporally related steps. These includ... | Polymerization of actin. IV. Role of Ca++ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm. When Pisaster, Asterias, or Thyone sperm are treated with the ionophore A23187 or X537A, an acrosomal reaction similar but not identical to a normal acrosomal reaction is induc... | [
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PMID:25902 | Polymerization of actin. V. A new organelle, the actomere, that initates the assembly of actin filaments in Thyone sperm. | Between the acrosomal vacuole and the nucleus is a cup of amorphous material (profilactin) which is transformed into filaments during the acrosomal reaction. In the center of this cup in untreated Thyone sperm is a dense material which I refer to as the actomere; it is composed of 20-25 filaments embedded in a dense ma... | Polymerization of actin. V. A new organelle, the actomere, that initates the assembly of actin filaments in Thyone sperm. Between the acrosomal vacuole and the nucleus is a cup of amorphous material (profilactin) which is transformed into filaments during the acrosomal reaction. In the center of this cup in untreated T... | [
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PMID:25903 | The development of lysosomal apparatus. I. Lysosomal enzyme activities in the liver of mice at perinatal stages and those of their mothers. | The enzymatic activity of five acid hydrolases: acid phosphatase, arylsulfatase A, deoxyribonuclease, beta-glucuronidase, and cathepsin D, was assayed in fetal (fifteenth and eighteenth days of pregnancy) and neonatal (Days 0, 5, 10, and 15 post-partum) mouse liver. With the exception of cathepsin D, the activity incre... | The development of lysosomal apparatus. I. Lysosomal enzyme activities in the liver of mice at perinatal stages and those of their mothers. The enzymatic activity of five acid hydrolases: acid phosphatase, arylsulfatase A, deoxyribonuclease, beta-glucuronidase, and cathepsin D, was assayed in fetal (fifteenth and eight... | [
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PMID:25904 | PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals. | Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations. Both a temporary increase in ampl... | PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals. Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to invest... | [
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PMID:25909 | Interpatient microbiological cross-contamination after dental radiographic examination. | Pairs of patients were evaluated for microbiological cross-contamination after radiographic examination. In 30 of these pairs of patients there was the possibility of transference of S pyogenes, S aureus, or D pneumoniae. Such transference was observed in 23 (77%) of these 30 pairs of patients. The vectors for such tra... | Interpatient microbiological cross-contamination after dental radiographic examination. Pairs of patients were evaluated for microbiological cross-contamination after radiographic examination. In 30 of these pairs of patients there was the possibility of transference of S pyogenes, S aureus, or D pneumoniae. Such trans... | [
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PMID:25910 | Tear pH: how predictable? | While the tear pH of a patient is now known to be continually shifting throughout the waking day, such variations were found to be contained within fairly narrow limits (a range here of about 0.6 of a pH unit). Further, sufficient repetition of these shifts occurred over 10 days observed that patterns distinctive of th... | Tear pH: how predictable? While the tear pH of a patient is now known to be continually shifting throughout the waking day, such variations were found to be contained within fairly narrow limits (a range here of about 0.6 of a pH unit). Further, sufficient repetition of these shifts occurred over 10 days observed that ... | [
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PMID:25934 | A novel immunoadsorbent: use for the preparation of monospecific antibodies to the hepatitis B antigen. | Controlled pore glass (CPG) adsorbs hepatitis B surface antigen (HBsAg) from whole plasma with a high degree of specificity. The resultant complex is stable at acid pH and in the presence of high concentrations of sodium thiocyanate. The adsorbed HBsAg is qualitatively and quantitatively similar to the soluble material... | A novel immunoadsorbent: use for the preparation of monospecific antibodies to the hepatitis B antigen. Controlled pore glass (CPG) adsorbs hepatitis B surface antigen (HBsAg) from whole plasma with a high degree of specificity. The resultant complex is stable at acid pH and in the presence of high concentrations of so... | [
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PMID:25935 | Sphingomyelinase in pig and human epidermis. | The enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which hydrolyzes sphingomyelin to ceramide (N-acylsphingosine) and phosphorylcholine was identified in the subcellular fractions of pig and human epidermis. The enzyme has an optimum pH of 4.5 to 5 and is activated by Triton X-1... | Sphingomyelinase in pig and human epidermis. The enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which hydrolyzes sphingomyelin to ceramide (N-acylsphingosine) and phosphorylcholine was identified in the subcellular fractions of pig and human epidermis. The enzyme has an optimum ... | [
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PMID:25938 | Collecting duct hydrogen ion secretion in the rabbit: role of potassium. | The purpose of this study was to investigate distal nephron hydrogen ion secretion in the intact animal. The rabbit was chosen as the experimental model because it produces acid urine containing little ammonium. Upon replacement of the usual rabbit diet with milk, plus administration of an acid load (10 mEq/kg), the ur... | Collecting duct hydrogen ion secretion in the rabbit: role of potassium. The purpose of this study was to investigate distal nephron hydrogen ion secretion in the intact animal. The rabbit was chosen as the experimental model because it produces acid urine containing little ammonium. Upon replacement of the usual rabbi... | [
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PMID:25939 | The distribution of bumps in the tail of the locust photoreceptor afterpotential. | An extended tail or prolonged depolarizing afterpotential (PDA) follows the receptor potential of a locust retinula cell when the stimulating light is in the intensity range that saturates the receptor potential. The amplitude and duration of this afterpotential depend on the intensity and duration of the stimulus. As ... | The distribution of bumps in the tail of the locust photoreceptor afterpotential. An extended tail or prolonged depolarizing afterpotential (PDA) follows the receptor potential of a locust retinula cell when the stimulating light is in the intensity range that saturates the receptor potential. The amplitude and duratio... | [
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PMID:25940 | Some responses of the electric ray (Torpedo marmorata) to low ambient oxygen tensions. | I. Blood samples were taken during prolonged hypoxia experiments in which the inspired water oxygen tension was less than 10 mmHg. The oxygen tension of the post-branchial blood was about 5 mmHg and its pH shows a significant lowering from normoxic levels. 2. The decrease in blood pH is correlated with increases in lev... | Some responses of the electric ray (Torpedo marmorata) to low ambient oxygen tensions. I. Blood samples were taken during prolonged hypoxia experiments in which the inspired water oxygen tension was less than 10 mmHg. The oxygen tension of the post-branchial blood was about 5 mmHg and its pH shows a significant lowerin... | [
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PMID:25941 | The identification of an octopaminergic neurone and the modulation of a myogenic rhythm in the locust. | An octopaminergic neurone in an insect is demonstrated. This cell (DUMETi) is the dorsal unpaired median neurone which projects to the extensor tibiae muscle of the locust metathoracic leg. Its soma was physiologically identified, isolated and shown to contain about 0.1 pmol of octopamine. Octopamine is about four time... | The identification of an octopaminergic neurone and the modulation of a myogenic rhythm in the locust. An octopaminergic neurone in an insect is demonstrated. This cell (DUMETi) is the dorsal unpaired median neurone which projects to the extensor tibiae muscle of the locust metathoracic leg. Its soma was physiologicall... | [
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PMID:25942 | Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation. | Bone marrow (BM) and skin allografts from C57BL/Ka (H-2b/b) mice were transplanted to BALB/c (H-2d/d) recipients treated with total lymphoid irradiation (TLI), whole-body irradiation (WBI), or fractionated thymic irradiation TLI prolonged skin allograft survival about five times as long as that in untreated controls, a... | Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation. Bone marrow (BM) and skin allografts from C57BL/Ka (H-2b/b) mice were transplanted to BALB/c (H-2d/d) recipients treated with total lymphoid irradiation (TLI), whole-body irradiation (WBI), or fractionated thym... | [
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PMID:25943 | Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. | Marrow stem cell lines from old donors and those from young controls gave equally rapid rates of colony growth on spleens of irradiated mice. Old and young stem cell lines competed equally well with chromosomally marked marrow stem cells from a young donor in producing cell types that are stimulated by bleeding; old ce... | Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. Marrow stem cell lines from old donors and those from young controls gave equally rapid rates of colony growth on spleens of irradiated mice. Old and young stem cell lines competed equally well with chromo... | [
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PMID:25944 | A comparative study of the electrode systems of three pH and blood gas apparatus. | We present a comparative evaluation of the electrode systems of three modern blood gas analysers: IL-413, ABL-1 and AVL-937C. The response curves, accuracy and precision of the pH-, pCO2- and pO2-electrodes were established with tonometered blood and buffer solutions. pH values (range 6.8-7.8) measured on the AVL devia... | A comparative study of the electrode systems of three pH and blood gas apparatus. We present a comparative evaluation of the electrode systems of three modern blood gas analysers: IL-413, ABL-1 and AVL-937C. The response curves, accuracy and precision of the pH-, pCO2- and pO2-electrodes were established with tonometer... | [
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PMID:25946 | Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system. | Short term exposure of PC-12 cells to dibutyryl cyclic AMP (dB-cAMP) results in an activation of tyrosine hydroxylase. In the cell-free system the PC-12 tyrosine hydroxylase activity is stimulated by addition of c-AMP, Mg+2 and ATP. Exogenous c-AMP dependent protein kinase further stumulates tyrosine hydroxylase activi... | Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system. Short term exposure of PC-12 cells to dibutyryl cyclic AMP (dB-cAMP) results in an activation of tyrosine hydroxylase. In the cell-free system the PC-12 tyrosine hydroxylase activity is stimulated by ... | [
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PMID:25945 | Intestinal transport of weak electrolytes: Determinants of influx at the luminal surface. | The determinants of weak electrolyte influx into everted segments of rat small intestine have been studied. Preliminary experiments showed that the observed influxes could be described as unidirectional, diffusional fluxes of the nonionized compound uncomplicated by a parallel ionic component. It is shown that the dete... | Intestinal transport of weak electrolytes: Determinants of influx at the luminal surface. The determinants of weak electrolyte influx into everted segments of rat small intestine have been studied. Preliminary experiments showed that the observed influxes could be described as unidirectional, diffusional fluxes of the ... | [
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PMID:25951 | Double mode of action of black widow spider venom on frog neuromuscular junction. | Black widow spider venom (BWSV) contains a toxin, alpha-latrotoxin, which is capable of stimulating vesicle release, resulting eventually in depletion of vesicles and block of neuromuscular transmission at the frog neuromuscular junction. Since it has been shown that alpha-latrotoxin very markedly increases the cation ... | Double mode of action of black widow spider venom on frog neuromuscular junction. Black widow spider venom (BWSV) contains a toxin, alpha-latrotoxin, which is capable of stimulating vesicle release, resulting eventually in depletion of vesicles and block of neuromuscular transmission at the frog neuromuscular junction.... | [
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PMID:25954 | N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems. | Comparative antimicrobial activity studies for certain new classes of soft N-chloramines derived from alpha-aminiisobutyric acid and 2-amino-2-methyl-1-propanol were examined using the minimum inhibitory concentration (MIC) and/or the contact germicidal efficiency (CGE) procedures. Several factors significantly aliphat... | N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems. Comparative antimicrobial activity studies for certain new classes of soft N-chloramines derived from alpha-aminiisobutyric acid and 2-amino-2-methyl-1-propanol were examined using the minimum inhibitory concentration (MIC) and/or th... | [
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PMID:25955 | Stability of aqueous solutions of mibolerone. | The kinetics and mechanism of degradation of mibolerone were studied in aqueous buffered solutions in the pH range of 1-8 at 67.5 degrees. Mibolerone showed maximum stability between pH 5.5 and 6.4. At pH 1-2, the major degradative pathway was dehydration followed by migration of the 18-methyl group to form 7alpha,17,1... | Stability of aqueous solutions of mibolerone. The kinetics and mechanism of degradation of mibolerone were studied in aqueous buffered solutions in the pH range of 1-8 at 67.5 degrees. Mibolerone showed maximum stability between pH 5.5 and 6.4. At pH 1-2, the major degradative pathway was dehydration followed by migrat... | [
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PMID:25957 | Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. | 1. The effects of decreasing pH from 7.40 to 6.20 on the tension developed by direct activation of the myofilaments and by Ca2+ release from the sarcoplasmic reticulum were studied comparatively in segments of single cells of skeletal muscle (frog semitendinosus) and cardiac muscle (rat ventricle) from which the sarcol... | Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. 1. The effects of decreasing pH from 7.40 to 6.20 on the tension developed by direct activation of the myofilaments and by Ca2+ release from the sarcoplasmic reticulum were studied comparatively in segm... | [
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PMID:25959 | The effects of pH and curare on the time course of end-plate currents at the neuromuscular junction of the frog. | 1. The effect of pH changes on synaptic currents has been analysed by external recording of the miniature end-plate currents (m.e.p.c.s) or by recording in voltage-clamped end-plates the current elicited by nerve stimulation (e.p.c.). 2. Changes in pH do not appreciably effect the peak amplitude of the current produced... | The effects of pH and curare on the time course of end-plate currents at the neuromuscular junction of the frog. 1. The effect of pH changes on synaptic currents has been analysed by external recording of the miniature end-plate currents (m.e.p.c.s) or by recording in voltage-clamped end-plates the current elicited by ... | [
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PMID:25960 | Effects of dithiothreitol on end-plate currents. | 1. End-plate currents have been studied in frog cutaneus pectoris nerve-muscle preparations mounted in continuously flowing solution, using the voltage clamp technique. 2. Exposure of the muscle to 1 mM-dithiothreitol reduced the amplitude of end-plate currents by a factor of 2.7 (mean; range 1.6-3.4; twelve fibres). 3... | Effects of dithiothreitol on end-plate currents. 1. End-plate currents have been studied in frog cutaneus pectoris nerve-muscle preparations mounted in continuously flowing solution, using the voltage clamp technique. 2. Exposure of the muscle to 1 mM-dithiothreitol reduced the amplitude of end-plate currents by a fact... | [
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PMID:25961 | Anion transport of the red cell under non-equilibrium conditions. | 1. The exchange of sulphate for chloride across the human red cell membrane was measured in both directions, i.e. by sulphate influx and sulphate efflux. The influence of the concomitant transient pH changes was minimized by phosphate buffer and by choosing experimental conditions of moderate pH sensitivity (pH 6.4 and... | Anion transport of the red cell under non-equilibrium conditions. 1. The exchange of sulphate for chloride across the human red cell membrane was measured in both directions, i.e. by sulphate influx and sulphate efflux. The influence of the concomitant transient pH changes was minimized by phosphate buffer and by choos... | [
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PMID:25967 | 5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanimines, potential antipsychotic agents. | The title compounds (most notably 2a) were synthesized on the basis of the N-methylation hypothesis of schizophrenia. They were evaluated in dopamine and haloperidol receptor assays. The binding characteristics were comparable in some cases to known neuroleptics. | 5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanimines, potential antipsychotic agents. The title compounds (most notably 2a) were synthesized on the basis of the N-methylation hypothesis of schizophrenia. They were evaluated in dopamine and haloperidol receptor assays. The binding characteristics were comparable in some ... | [
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PMID:25968 | Chemical and electrochemical oxidation of 7-hydroxychlorpromazine. | The oxidation of 7-hydroxychlorpromazine, a process associated with several side effects of chlorpromazine therapy, was examined in vitro by electrochemistry and rapid-scanning spectrophotometry. At pH 2, the oxidation results in a quantitative yield of 7,8-dioxochlorpromazine, but several intermediates are observable ... | Chemical and electrochemical oxidation of 7-hydroxychlorpromazine. The oxidation of 7-hydroxychlorpromazine, a process associated with several side effects of chlorpromazine therapy, was examined in vitro by electrochemistry and rapid-scanning spectrophotometry. At pH 2, the oxidation results in a quantitative yield of... | [
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PMID:25970 | The incidence of mosquitoes feeding on mothers and babies at Kisumu, Kenya. | Blood fed mosquitoes were collected inside four bed nets in which mother/child pairs, having different haptoglobin types, slept. The bloodmeals were analysed by gradient gel electrophoresis to determine on which person the mosquitoes had fed. The results suggest that the mothers are fed on much more than babies by both... | The incidence of mosquitoes feeding on mothers and babies at Kisumu, Kenya. Blood fed mosquitoes were collected inside four bed nets in which mother/child pairs, having different haptoglobin types, slept. The bloodmeals were analysed by gradient gel electrophoresis to determine on which person the mosquitoes had fed. T... | [
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PMID:25971 | Experience with 425 subfertile male patients. | Subfertility was evaluated in 425 men. Varicocele were diagnosed in 37.4 per cent of these patients and surgical correction of the varicocele in 68 men resulted in a 65 per cent improvement in semen quality. Idiopathic abnormalities were found in 25.4 per cent of the patients. Since the study group was heterogenous set... | Experience with 425 subfertile male patients. Subfertility was evaluated in 425 men. Varicocele were diagnosed in 37.4 per cent of these patients and surgical correction of the varicocele in 68 men resulted in a 65 per cent improvement in semen quality. Idiopathic abnormalities were found in 25.4 per cent of the patien... | [
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PMID:25973 | Effects of Kö 1366 on the hemodynamics of the normotensive and hypertensive elderly subjects. | The hemodynamic effects of a new adrenergic beta-receptor blocking agent, Kö 1366 were investigated in normotensive and hypertensive elderly subjects. This study, in its important part, was carried out to clarify whether the intrinsic sympathomimetic activity of Kö 1366 modified the hemodynamic changes due to beta-adre... | Effects of Kö 1366 on the hemodynamics of the normotensive and hypertensive elderly subjects. The hemodynamic effects of a new adrenergic beta-receptor blocking agent, Kö 1366 were investigated in normotensive and hypertensive elderly subjects. This study, in its important part, was carried out to clarify whether the i... | [
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PMID:25987 | [Metabolic changes in the retina after experimental microembolism in the miniature pig (author's transl)]. | Experimental microembolisation provokes hemodynamics and metabolic changes in the inner retina. The metabolic modifications are the consequence of focal tissue ischaemia and have as a main feature, the activation of anaerobic glycolysis. This activation produces an increase in the production of lactic acid which, in tu... | [Metabolic changes in the retina after experimental microembolism in the miniature pig (author's transl)]. Experimental microembolisation provokes hemodynamics and metabolic changes in the inner retina. The metabolic modifications are the consequence of focal tissue ischaemia and have as a main feature, the activation ... | [
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PMID:26006 | [Apparatus for the multichannel pH measurement of the upper section of the gastrointestinal tract]. | To study simultaneously the acid-base processes in the esophagus, stomach and duodenum a procedure involving the use of multichannel pH measurements is proposed and a setup designed whose basic elements are a 6-channel pH-probe and a registering device. A visual and graphic registration of the investigation results is ... | [Apparatus for the multichannel pH measurement of the upper section of the gastrointestinal tract]. To study simultaneously the acid-base processes in the esophagus, stomach and duodenum a procedure involving the use of multichannel pH measurements is proposed and a setup designed whose basic elements are a 6-channel p... | [
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PMID:26014 | Tardive dyskinesia and antihistamines. | A case of tardive dyskinesia due to the prolonged administration of antihistamines is reported. Clinical features are discussed, as well as the alleviation of these by haloperidol. | Tardive dyskinesia and antihistamines. A case of tardive dyskinesia due to the prolonged administration of antihistamines is reported. Clinical features are discussed, as well as the alleviation of these by haloperidol. | [
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PMID:26015 | Labetalol in the treatment of hypertensive renal patients. | The efficacy of labetalol in lowering blood pressure was assessed in 18 patients with chronic renal failure and hypertension. Before the start of labetalol therapy, all patients were receiving combined antihypertensive therapy, the most common being a beta-blocker and hydrallazine. Over the period of about four weeks l... | Labetalol in the treatment of hypertensive renal patients. The efficacy of labetalol in lowering blood pressure was assessed in 18 patients with chronic renal failure and hypertension. Before the start of labetalol therapy, all patients were receiving combined antihypertensive therapy, the most common being a beta-bloc... | [
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PMID:26012 | [Acidophilic thermotolerant Candida utilis yeast strain obtained by continuous cultivation]. | An acidophilic thermotolerant strain of Candida utilis 1668-3-37 was produced under conditions of continuous cultivation during 128 days. The optimum pH is 3.0-4.5 at 32 degrees C. The strain grows with mumax=0.30 hr(-1) at 37-38 degrees C and the same pH values if dry yeast autolysate (0.05%) is added to the medium. | [Acidophilic thermotolerant Candida utilis yeast strain obtained by continuous cultivation]. An acidophilic thermotolerant strain of Candida utilis 1668-3-37 was produced under conditions of continuous cultivation during 128 days. The optimum pH is 3.0-4.5 at 32 degrees C. The strain grows with mumax=0.30 hr(-1) at 37-... | [
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PMID:26013 | [Metal content in Bacillus megaterium cells under different cultivation conditions]. | The content of K, Na, Mg, Fe, Al, Ba, Sr and Cu was studied in the cells of a chemostal culture of Bacillus megaterium whose growth was limited with citrate, the growth rates being D=mu=0.2, 0.4 and 0.7 hr(-1). The growth was affected also by acid and alkaline values of pH. The content of metals in the cells could chan... | [Metal content in Bacillus megaterium cells under different cultivation conditions]. The content of K, Na, Mg, Fe, Al, Ba, Sr and Cu was studied in the cells of a chemostal culture of Bacillus megaterium whose growth was limited with citrate, the growth rates being D=mu=0.2, 0.4 and 0.7 hr(-1). The growth was affected ... | [
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PMID:26019 | Specific inactivation of heterospecific transforming DNA by a factor derived from Streptococcus sanguis lysates. | A heat-sensitive factor obtained from lysates of competent Streptococcus sanguis cells reacts specifically with native DNA of heterospecific (S. pneumoniae or calf thymus) origin. In vitro it does not alter the double or single strand length of the DNA, nor does it affect uptake of the DNA by compentent S. pneumoniae c... | Specific inactivation of heterospecific transforming DNA by a factor derived from Streptococcus sanguis lysates. A heat-sensitive factor obtained from lysates of competent Streptococcus sanguis cells reacts specifically with native DNA of heterospecific (S. pneumoniae or calf thymus) origin. In vitro it does not alter ... | [
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PMID:26020 | The properties of mnemiopsin, a bioluminescent and light sensitive protein purified by hollow fiber techniques. | A calcium activated photoprotein, termed mnemiopsin, which emits bioluminescence upon the addition of calcium ion, has been isolated from the Ctenophore, Memiopsis leidyi, and purified by hollow fiber techniques. The system is similar to aequorin, from the jellyfish Aequorea, except that mnemiopsin can be light-inactiv... | The properties of mnemiopsin, a bioluminescent and light sensitive protein purified by hollow fiber techniques. A calcium activated photoprotein, termed mnemiopsin, which emits bioluminescence upon the addition of calcium ion, has been isolated from the Ctenophore, Memiopsis leidyi, and purified by hollow fiber techniq... | [
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PMID:26021 | Extraction of tyrosine aminotransferase mRNA by polyribosome immunosorption on sepharose 4B. | Sepharose 4B column with antibody to tyrosine aminotransferase (E.C. 2.6.1.5) (TAT) covalently bound can selectively remove a specific fraction of TAT polysomes from rat liver homogenates. From the polysomes which was adsorbed by immunosorbent one may obtain mRNA containing a segment of poly-adenilate-rich residues, ha... | Extraction of tyrosine aminotransferase mRNA by polyribosome immunosorption on sepharose 4B. Sepharose 4B column with antibody to tyrosine aminotransferase (E.C. 2.6.1.5) (TAT) covalently bound can selectively remove a specific fraction of TAT polysomes from rat liver homogenates. From the polysomes which was adsorbed ... | [
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PMID:26028 | The binding of intravenous and oral biliary contrast agents to human and bovine serum albumin. | The binding of two homologous series of oral and intravenous biliary contrast agents to human and bovine serum albumin was investigated using the gel filtration technique. All intravenous compounds are bound to human serum albumin via one high affinity and several low affinity binding sites. Within the concentration ra... | The binding of intravenous and oral biliary contrast agents to human and bovine serum albumin. The binding of two homologous series of oral and intravenous biliary contrast agents to human and bovine serum albumin was investigated using the gel filtration technique. All intravenous compounds are bound to human serum al... | [
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PMID:26036 | [Hemorrhagic rectocolitis. Attempt at programmed therapy]. | Planned treatment of 30 cases of haemorrhagic colitis is reported. Its protocol included salazopyrine and benzodiazepine per os, salazopyrine and prednisone per rectum, and parenteral ACTH depot. Administration for 60 days brought good results in cases of slight or average severity. Recurrences, albeit less severe, wer... | [Hemorrhagic rectocolitis. Attempt at programmed therapy]. Planned treatment of 30 cases of haemorrhagic colitis is reported. Its protocol included salazopyrine and benzodiazepine per os, salazopyrine and prednisone per rectum, and parenteral ACTH depot. Administration for 60 days brought good results in cases of sligh... | [
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PMID:26038 | Expression of hormonally induced tyrosine aminotransferase in host liver and Morris hepatoma No. 7777 during cofactor depletion. | Cytoplasmic tyrosine aminotransferase (L-tyrosine: 2-oxoglutarate aminotransferase, EC2.6.1.5) was partially purified from host liver and Morris hepatoma No. 7777 grown in pyridoxine depleted rats. The animals were sacrificed six hours following the intraperitoneal administration of hydrocortisone hemisuccinate. Enzyme... | Expression of hormonally induced tyrosine aminotransferase in host liver and Morris hepatoma No. 7777 during cofactor depletion. Cytoplasmic tyrosine aminotransferase (L-tyrosine: 2-oxoglutarate aminotransferase, EC2.6.1.5) was partially purified from host liver and Morris hepatoma No. 7777 grown in pyridoxine depleted... | [
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PMID:26041 | [The detection of bacterial antigens by counter-immunoelectrophoresis in N. meningitidis, H. influenzae serotype b, S. pneumoniae infections. Diagnostic value and evolutive aspect (in 216 cases) (author's transl)]. | Using counterimmunoelectrophoresis (CIE) the authors have assayed for soluble bacterial S. pneumoniae, N meningitidis group A, B, C. H. influenzae type b antigens, biological fluids in 216 patients (meningitis: 136; pneumonia: 76; miscellaneous: 4) during 16 months. Because of heterogeneous recruiting (the bacteriology... | [The detection of bacterial antigens by counter-immunoelectrophoresis in N. meningitidis, H. influenzae serotype b, S. pneumoniae infections. Diagnostic value and evolutive aspect (in 216 cases) (author's transl)]. Using counterimmunoelectrophoresis (CIE) the authors have assayed for soluble bacterial S. pneumoniae, N ... | [
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PMID:26042 | A new method for the purification and identification of covalently closed circular DNA molcules. | A new technique has been developed for the rapid isolation of covalently closed circular DNA molecules. The procedure is a selective extraction based on differences in the partitioning of covalently closed circular DNA molecules and noncovalently closed species between phenol and water at acid pH and low ionic strength... | A new method for the purification and identification of covalently closed circular DNA molcules. A new technique has been developed for the rapid isolation of covalently closed circular DNA molecules. The procedure is a selective extraction based on differences in the partitioning of covalently closed circular DNA mole... | [
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PMID:26043 | Synthesis and properties of 8-azido-1, N6-etheno adenosine triphosphate--a fluorescent and photosensitive ATP analog. | 8-Azido-1,N6-etheno-ATP--a fluorescent and photoreactive ATP analog has been synthesized and characterized by elementary analysis, thin layer chromatography, infrared spectroscopy, proton resonance spectroscopy, UV absorption spectroscopy, and fluorescence spectroscopy. The photolytical decomposition upon irradiation a... | Synthesis and properties of 8-azido-1, N6-etheno adenosine triphosphate--a fluorescent and photosensitive ATP analog. 8-Azido-1,N6-etheno-ATP--a fluorescent and photoreactive ATP analog has been synthesized and characterized by elementary analysis, thin layer chromatography, infrared spectroscopy, proton resonance spec... | [
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PMID:26044 | Short RNA chains synthesized at low pH are initiated at promoter sites. | Under non optimal conditions- either with limiting substrate concentrations (1) or at low pH (2)- RNA polymerase of Escherichia coli synthesizes very short RNA chains. By sequencing one RNA species synthesized at pH 5.8 upon T7 DNA we were able to demonstrate that under these conditions transcription is initiated at a ... | Short RNA chains synthesized at low pH are initiated at promoter sites. Under non optimal conditions- either with limiting substrate concentrations (1) or at low pH (2)- RNA polymerase of Escherichia coli synthesizes very short RNA chains. By sequencing one RNA species synthesized at pH 5.8 upon T7 DNA we were able to ... | [
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PMID:26050 | [Polarographic method of determining phenol in the air]. | A specific, highly sensitive and exact polarographic method of phenol determination in the air is developed. The conditions of sample taking are outlined, and the effect of polarographic solution pH on the height of step and semi-wave potential is verified. The suggested method is readily applicable simple for executio... | [Polarographic method of determining phenol in the air]. A specific, highly sensitive and exact polarographic method of phenol determination in the air is developed. The conditions of sample taking are outlined, and the effect of polarographic solution pH on the height of step and semi-wave potential is verified. The s... | [
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PMID:26051 | Minichromosome from BK virus as a template for transcription in vitro. | BK virus DNA can be extracted from virions as a nucleoprotein complex containing about 20 nucleosomes. Transcription of this "minichromosome" with Escherichia coli RNA polymerase indicates that both initiation and elongation of RNA chains are reduced by the presence of nucleosomes. Hybridization analysis of RNA made on... | Minichromosome from BK virus as a template for transcription in vitro. BK virus DNA can be extracted from virions as a nucleoprotein complex containing about 20 nucleosomes. Transcription of this "minichromosome" with Escherichia coli RNA polymerase indicates that both initiation and elongation of RNA chains are reduce... | [
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PMID:26052 | Transglutaminase activity in human lymphocytes: early activation by phytomitogens. | Transglutaminase activity is present in human peripheral lymphocytes and is enhanced up to 15-fold within 10-30 min after treatment of the cells with concanavalin A. Phytohemagglutinin has a similar effect. The enzyme is not detected when intact cells are assayed; it is detected only in cell lysates. Concanavalin A enh... | Transglutaminase activity in human lymphocytes: early activation by phytomitogens. Transglutaminase activity is present in human peripheral lymphocytes and is enhanced up to 15-fold within 10-30 min after treatment of the cells with concanavalin A. Phytohemagglutinin has a similar effect. The enzyme is not detected whe... | [
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PMID:26053 | Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31P nuclear magnetic resonance and fluorescence energy transfer study. | The paramagnetic effect of Mn(II) on (13)C and (31)P nuclear magnetic resonance signals from the [2-(13)C]ATP adenylylated glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming); EC 6.3.1.2] from Escherichia coli was measured. This effect permitted the determination of distances from the 2-C position and the ph... | Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31P nuclear magnetic resonance and fluorescence energy transfer study. The paramagnetic effect of Mn(II) on (13)C and (31)P nuclear magnetic resonance signals from the [2-(13)C]ATP adenylylated glutam... | [
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PMID:26054 | Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle: electron probe analysis. | Electron probe analysis, cryo-ultramicrotomy, and freeze-substitution were used to determine the nature of vacuolation and the subcellular composition in fatigued frog skeletal muscle fibers. The vacuoles caused by fatigue were part of the T-tubule system and contained high concentrations of NaCl. The calcium concentra... | Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle: electron probe analysis. Electron probe analysis, cryo-ultramicrotomy, and freeze-substitution were used to determine the nature of vacuolation and the subcellular composition in fatigued frog skeletal muscle fibers. The vacuoles caused by fatigue w... | [
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PMID:26055 | Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP. | The 3T3-L1 mouse fibroblast cell line develops morphological and biochemical characteristics of adipocytes when maintained at confluence. This conversion to adipocytes is accelerated by addition of insulin to the culture medium [Green, H. & Kehinde, O. (1975) Cell 5, 19-27]. During the course of the insulin-mediate... | Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP. The 3T3-L1 mouse fibroblast cell line develops morphological and biochemical characteristics of adipocytes when maintained at confluence. This conversion to adipocytes is accelerated by addition of insulin ... | [
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PMID:26062 | Crosslinking of the nearest membrane protein neighbors in ATP depleted, calcium enriched and irreversibly sickled red cells. | ATP depleted or Ca2+ (0.1 mM) enriched normal red cells (greater than 80% echinocytes III) subjected to crosslinking by catalytic oxidation contain a greater than 1,000,000 daltons spectrin rich polymer cleavable by dithiothreitol (DTT) reduction. Similar complex is seen after glutaraldehyde crosslinking suggesting spe... | Crosslinking of the nearest membrane protein neighbors in ATP depleted, calcium enriched and irreversibly sickled red cells. ATP depleted or Ca2+ (0.1 mM) enriched normal red cells (greater than 80% echinocytes III) subjected to crosslinking by catalytic oxidation contain a greater than 1,000,000 daltons spectrin rich ... | [
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0.016474440693855286,
0.... |
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