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PMID:26063 | Pipradrol enhances reinforcing properties of stimuli paired with brain stimulation. | The hypothesis that a psychomotor stimulant drug (pipradrol) enhances the reinforcing effects of stimuli paired with reinforcing brain stimulation was tested using a conditioned reinforcement paradigm. Rats were trained to discriminate between two stimuli (S+ and S-) to obtain ICS in the lateral hypothalamus by pushing... | Pipradrol enhances reinforcing properties of stimuli paired with brain stimulation. The hypothesis that a psychomotor stimulant drug (pipradrol) enhances the reinforcing effects of stimuli paired with reinforcing brain stimulation was tested using a conditioned reinforcement paradigm. Rats were trained to discriminate ... | [
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PMID:26066 | Nucleosome structure. | Electron microscopic and biochemical results are presented supporting the following conclusions: (1) Two molecules of each histone H2A, H2B, H3 and H4 are necessary and sufficient to form a nucleosome with a diameter of 12.5 +/- 1 nm and containing about 200 base pairs of DNA. (2) H3 plus H4 alone can compact 129 +/- 8... | Nucleosome structure. Electron microscopic and biochemical results are presented supporting the following conclusions: (1) Two molecules of each histone H2A, H2B, H3 and H4 are necessary and sufficient to form a nucleosome with a diameter of 12.5 +/- 1 nm and containing about 200 base pairs of DNA. (2) H3 plus H4 alone... | [
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PMID:26068 | Relation of nucleosomes to nucleotide sequences in the rat. | The relation of nucleosomes to nucleotide sequences is random for most single copy sequences in rat liver. This could be due to variation in the DNA content of nucleosomes, and a procedure for detecting such variation is described. | Relation of nucleosomes to nucleotide sequences in the rat. The relation of nucleosomes to nucleotide sequences is random for most single copy sequences in rat liver. This could be due to variation in the DNA content of nucleosomes, and a procedure for detecting such variation is described. | [
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PMID:26072 | Conformational flexibility in DNA structure and its implications in understanding the organization of DNA in chromatin. | X-ray crystallographic studies of drug-nucleic acid crystalline complexes have suggested that DNA first bends or 'kinks' before accepting an intercalative drug or dye. This flexibility in DNA structure is made possible by altering the normal C2' endo deoxyribose sugar puckering in B DNA to a mixed sugar puckering patte... | Conformational flexibility in DNA structure and its implications in understanding the organization of DNA in chromatin. X-ray crystallographic studies of drug-nucleic acid crystalline complexes have suggested that DNA first bends or 'kinks' before accepting an intercalative drug or dye. This flexibility in DNA structur... | [
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PMID:26073 | The structure of SV 40 chromatin. | Simian virus 40 (SV40) nucleoprotein complexes were studied with the electron microscope. Depending on the isolation procedure, SV40 chromatin has two different conformations: complexes isolated in the presence of 0.15 M NaCl appeared as very compact globular structures, while those isolated in the presence of 0.6 M Na... | The structure of SV 40 chromatin. Simian virus 40 (SV40) nucleoprotein complexes were studied with the electron microscope. Depending on the isolation procedure, SV40 chromatin has two different conformations: complexes isolated in the presence of 0.15 M NaCl appeared as very compact globular structures, while those is... | [
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PMID:26076 | Aspects of the regulation of histone genes. | Sequencing of cloned histone DNA of the sea urchin Psammechinus miliaris has confirmed the map of the histone genes obtained earlier by rather less refined techniques. Sequencing of spacer has revealed that it is unlikely to code for protein. Some interesting sequences in the prelude regions to the structural genes hav... | Aspects of the regulation of histone genes. Sequencing of cloned histone DNA of the sea urchin Psammechinus miliaris has confirmed the map of the histone genes obtained earlier by rather less refined techniques. Sequencing of spacer has revealed that it is unlikely to code for protein. Some interesting sequences in the... | [
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PMID:26080 | Organization of transcribed regions of chromatin. | The endonuclease DNase II preferentially attacks a limited and tissue-specific portion of chromosomal DNA. This material may be separated from the bulk of chromatin DNA by virtue of its solubility in 2 mM MgCl2. The Mg2+ soluble fraction forms a specific subset of DNA sequences and is enriched four to sevenfold in sequ... | Organization of transcribed regions of chromatin. The endonuclease DNase II preferentially attacks a limited and tissue-specific portion of chromosomal DNA. This material may be separated from the bulk of chromatin DNA by virtue of its solubility in 2 mM MgCl2. The Mg2+ soluble fraction forms a specific subset of DNA s... | [
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PMID:26081 | The organization of transcription on lampbrush chromosomes. | The meiotic lampbrush chromosomes of amphibian oocytes display readily distinguishable regions of transcription (lateral loops) which extend from axial condensates of chromatin (chromomeres). The chromomeres contain most of the chromosomal ENA which, along with histone, is tightly compacted as regular arrays of DNP. Ma... | The organization of transcription on lampbrush chromosomes. The meiotic lampbrush chromosomes of amphibian oocytes display readily distinguishable regions of transcription (lateral loops) which extend from axial condensates of chromatin (chromomeres). The chromomeres contain most of the chromosomal ENA which, along wit... | [
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PMID:26087 | The 75 S RNA transcription unit in Balbiani ring 2 and its relation to chromosome structure. | A defined transcription unit in the Balbiani ring 2 (BR 2) region of chromosome IV in the salivary glands of Chironomus tentans has been characterized on the basis of analysis of the corresponding primary transcript, 75S RNA, and its functional significance. The available information on the transcription unit and its r... | The 75 S RNA transcription unit in Balbiani ring 2 and its relation to chromosome structure. A defined transcription unit in the Balbiani ring 2 (BR 2) region of chromosome IV in the salivary glands of Chironomus tentans has been characterized on the basis of analysis of the corresponding primary transcript, 75S RNA, a... | [
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PMID:26088 | Heat shock of Drosophila melanogaster induces the synthesis of new messenger RNAs and proteins. | The heat shock proteins, labelled in vivo with [35S]methionine, were separated by sodium dodecylsulphate-polyacrylamide gel electrophoresis and fingerprinted after tryptic digestion. Eight distinct heat shock polypeptides are characterized in this way. Heat shock messenger RNAs were isolated and partially purified. Ass... | Heat shock of Drosophila melanogaster induces the synthesis of new messenger RNAs and proteins. The heat shock proteins, labelled in vivo with [35S]methionine, were separated by sodium dodecylsulphate-polyacrylamide gel electrophoresis and fingerprinted after tryptic digestion. Eight distinct heat shock polypeptides ar... | [
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PMID:26090 | Transcription in the interbands of Drosophila. | Many interbands of Drosophila contain morphological evidence for transcription. Decondensed band material makes no detectable contribution to certain transcriptionally active interbands. | Transcription in the interbands of Drosophila. Many interbands of Drosophila contain morphological evidence for transcription. Decondensed band material makes no detectable contribution to certain transcriptionally active interbands. | [
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PMID:26094 | Antihypertensive drugs and depression: a reappraisal. | Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically physically ill out-patients completed a mood rating scale at regular intervals for one year. The results showed a high prevalence of depression in both groups of patients, with no preponderance in the hypertensive group.... | Antihypertensive drugs and depression: a reappraisal. Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically physically ill out-patients completed a mood rating scale at regular intervals for one year. The results showed a high prevalence of depression in both groups of pati... | [
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PMID:26095 | The behavioural actions of the hypothalamic peptides: a review. | Recent work has shown that the hypothalamic peptides commonly associated with the control of pituitary function have important behavioural actions of possible psychiatric significance. Thus, vasopressin, ACTH and like peptides may influence memory processes, and ACTH and MSH given intracranially induce a peculiar stret... | The behavioural actions of the hypothalamic peptides: a review. Recent work has shown that the hypothalamic peptides commonly associated with the control of pituitary function have important behavioural actions of possible psychiatric significance. Thus, vasopressin, ACTH and like peptides may influence memory processe... | [
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PMID:26096 | Factor analysis of a sleep evaluation questionnaire. | A self-completion sleep evaluation questionnaire (SEQ), consisting of 10 cm line analogue rating scale questions, was constructed to investigate subjects' responses to aspects of sleep and early morning behaviour. The questions were grouped into 4 chronological areas: the ease of getting to sleep (GTS), the perceived q... | Factor analysis of a sleep evaluation questionnaire. A self-completion sleep evaluation questionnaire (SEQ), consisting of 10 cm line analogue rating scale questions, was constructed to investigate subjects' responses to aspects of sleep and early morning behaviour. The questions were grouped into 4 chronological areas... | [
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PMID:26098 | Some altered responses in rats formerly dependent on morphine. | The investigation examined whether or not physical dependence or other abnormalities were detectable 1--3 months after withdrawal in dependent rats that had been treated with the morphine (amintenance dose of 100 X 2 mg/kg/day, s.c.) for 7 weeks. When narcotic antagonists were administered on the 32nd day after withdra... | Some altered responses in rats formerly dependent on morphine. The investigation examined whether or not physical dependence or other abnormalities were detectable 1--3 months after withdrawal in dependent rats that had been treated with the morphine (amintenance dose of 100 X 2 mg/kg/day, s.c.) for 7 weeks. When narco... | [
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PMID:26099 | Comparison studies of chlorazepate administered as a divided daily dose and as a single dose at night. | The residual effects of dipotassium chlorazepate administered as either a single daily dose of 20 mg at bedtime or a divided daily dose (5 + 5 + 10 mg) were studied in a placebo-controlled, double-blind trial comprising 12 out-patients. The following tests were used to determine changes in perceptual wakefulness, perfo... | Comparison studies of chlorazepate administered as a divided daily dose and as a single dose at night. The residual effects of dipotassium chlorazepate administered as either a single daily dose of 20 mg at bedtime or a divided daily dose (5 + 5 + 10 mg) were studied in a placebo-controlled, double-blind trial comprisi... | [
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PMID:26100 | A survey study of the use of electropupillogram in predicting response to psychostimulants. | To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) aft... | A survey study of the use of electropupillogram in predicting response to psychostimulants. To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children... | [
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PMID:26101 | Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine and L-dopa to rats. | Injection of rats with tranylcypromine and L-dopa increased brain dopamine concentrations and produced a behavioural syndrome that includes hyperactivity. It also elevated caudate nucleus cyclic AMP concentrations by approximately 50% in vivo, probably by stimulating dopamine receptors. Pretreatment with chlorpromazine... | Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine and L-dopa to rats. Injection of rats with tranylcypromine and L-dopa increased brain dopamine concentrations and produced a behavioural syndrome that includes hy... | [
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PMID:26109 | Labilization of brain lysosomes by trichloroethylene metabolites and peroxide anion in vitro. | Lysosomes were isolated from adult male Wistar rat brain and incubated in vitro with 10 micron trichloroethylene and microsomes or postmicrosomal supernatant with added NADPH. Freezing and incubation with the solvent alone served as controls. The results were compared with the effect of peroxide anion from the xanthine... | Labilization of brain lysosomes by trichloroethylene metabolites and peroxide anion in vitro. Lysosomes were isolated from adult male Wistar rat brain and incubated in vitro with 10 micron trichloroethylene and microsomes or postmicrosomal supernatant with added NADPH. Freezing and incubation with the solvent alone ser... | [
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PMID:26110 | Changes in plasma high density lipoproteins in chronic male alcoholics during and after abuse. | Alterations in plasma high density lipoproteins (HDL) were studied in thirty-eight male chronic alcoholics. Twenty-four (63%) of the patients had increased HDL protein (measured immunochemically) and twenty-five (66%) had increased HDL cholesterol (determined after polyanion precipitation of very low density lipoprotei... | Changes in plasma high density lipoproteins in chronic male alcoholics during and after abuse. Alterations in plasma high density lipoproteins (HDL) were studied in thirty-eight male chronic alcoholics. Twenty-four (63%) of the patients had increased HDL protein (measured immunochemically) and twenty-five (66%) had inc... | [
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PMID:26111 | Evidence for two types of non-specific suppressor cells activated by the graft-versus-host reaction in mice. | In vitro experiments were carried out to investigate the immunosuppressive efect of different populations of spleen cells obtained from animal experiencing a graft-versus-host reaction (GVHR). To induce the GVHR, parental lymphoid cells were injected into adult F1 hybrid mice. GVHR-activated spleen cells (GVH-sc) taken... | Evidence for two types of non-specific suppressor cells activated by the graft-versus-host reaction in mice. In vitro experiments were carried out to investigate the immunosuppressive efect of different populations of spleen cells obtained from animal experiencing a graft-versus-host reaction (GVHR). To induce the GVHR... | [
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PMID:26113 | The rapidity of bronchodilatation. A comparison of isoprenaline, terbutaline and rimiterol. | The onset of action of three sympathomimetic drugs (rimiterol 0.2 mg, terbutaline 0.25 mg and isoprenaline 0.08 mg) administered by metered dose inhaler was compared in 12 asthmatics. In order to evaluate side effects of the drugs, a second dose of the aerosols, 8-10 times higher than the first one, was given after 30 ... | The rapidity of bronchodilatation. A comparison of isoprenaline, terbutaline and rimiterol. The onset of action of three sympathomimetic drugs (rimiterol 0.2 mg, terbutaline 0.25 mg and isoprenaline 0.08 mg) administered by metered dose inhaler was compared in 12 asthmatics. In order to evaluate side effects of the dru... | [
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PMID:26114 | [Role of metabolites in the relationship between pharmacokinetics and the effect of beta blockers. Studies on tolamolol and bufuralol]. | Plasma concentrations of tolamolol and bufuralol (beta-blocking agents) were measured after oral and intravenous administration to healthy volunteers. The plasma levels of their main metabolite was also determined. Simultaneously, the effect of the drugs on the heart rate and blood pressure was monitored under various ... | [Role of metabolites in the relationship between pharmacokinetics and the effect of beta blockers. Studies on tolamolol and bufuralol]. Plasma concentrations of tolamolol and bufuralol (beta-blocking agents) were measured after oral and intravenous administration to healthy volunteers. The plasma levels of their main m... | [
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PMID:26130 | Graft-versus-host reactions within the thyroid gland may evoke pari passu autoimmune thyroiditis. | Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes. Surprisingly, significant mononuclear cell infiltration was also seen within the contralateral (... | Graft-versus-host reactions within the thyroid gland may evoke pari passu autoimmune thyroiditis. Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes... | [
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PMID:26136 | [Risk of surgery at the height of a gastroduodenal hemorrhage]. | The authors believe that the decrease of mortality in operations for gastroduodenal bleeding does not depend on the time interval between the start of bleeding and surgical interventions, but it depends upon the conditions under which these interventions are carried out. The conditions should approximate the conditions... | [Risk of surgery at the height of a gastroduodenal hemorrhage]. The authors believe that the decrease of mortality in operations for gastroduodenal bleeding does not depend on the time interval between the start of bleeding and surgical interventions, but it depends upon the conditions under which these interventions a... | [
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PMID:26139 | [Haemodynamic characterization of a new beta-receptor blocker celiprolol (st1396) at rest and during ergometer exercise compared with propranolol (inderal) (author's transl)]. | A new beta-receptor blocker (Celiprolol) was characterized in man by haemodynamic studies carried out on a random cross-over basis in 6 volunteers before and after intravenous administration of the drug or propranolol. The studies were performed at rest and in response to ergometer exercise. The studies showed that: 1.... | [Haemodynamic characterization of a new beta-receptor blocker celiprolol (st1396) at rest and during ergometer exercise compared with propranolol (inderal) (author's transl)]. A new beta-receptor blocker (Celiprolol) was characterized in man by haemodynamic studies carried out on a random cross-over basis in 6 voluntee... | [
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PMID:26142 | [Experimental study concerning the psychological preparation to parturition (author's transl)]. | The following study reports an application to primae gravidae of two different psychological treatments aiming at reducing the fear of childbearing and facilitating the delivery. The treatments under comparison were systematic desensitization and modification of self instruction, a more cognitive approach. The effects ... | [Experimental study concerning the psychological preparation to parturition (author's transl)]. The following study reports an application to primae gravidae of two different psychological treatments aiming at reducing the fear of childbearing and facilitating the delivery. The treatments under comparison were systemat... | [
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PMID:26155 | [The influence on efficacy of formaldehyd and phenol against bacterial cells I. Effect of drying, cations and pH-value (author's transl)]. | 1. When cells of E. coli and Staph. aureus are dried, the efficacy of phenol is reduced but the efficacy of formaldehyde is increased. 2. A change of the aw-value by addition of salts changes the efficacy of formaldehyde as well as that of phenol. For these tests the chlorides of various alkali and alkaline earth metal... | [The influence on efficacy of formaldehyd and phenol against bacterial cells I. Effect of drying, cations and pH-value (author's transl)]. 1. When cells of E. coli and Staph. aureus are dried, the efficacy of phenol is reduced but the efficacy of formaldehyde is increased. 2. A change of the aw-value by addition of sal... | [
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PMID:26158 | Changes in gastric secretion following administration of preparations affecting the parasympathetic and sympathetic nervous system. | The changes in gastric secretion following administration of different preparations have been studied in a group of 180 patients with duodenal ulcer and chronic gastritis. In patients with hypersecretion the medication with bishpan and inderal as compared with atropine caused considerable shifts in the indices of gast... | Changes in gastric secretion following administration of preparations affecting the parasympathetic and sympathetic nervous system. The changes in gastric secretion following administration of different preparations have been studied in a group of 180 patients with duodenal ulcer and chronic gastritis. In patients wit... | [
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PMID:26159 | Cardiovascular effects of local adrenaline infiltration during halothane anaesthesia and adrenergic beta-receptor blockade in man. | Adrenergic beta-receptor blocking agents, alprenolol, propranolol and practolol were given as a prophylactic measure to patients undergoing middle-ear microsurgery where adrenaline was deliberately infiltrated during halothane-N2O/O2 anaesthesia. These three beta blockers did not differ in their action on heart rate, a... | Cardiovascular effects of local adrenaline infiltration during halothane anaesthesia and adrenergic beta-receptor blockade in man. Adrenergic beta-receptor blocking agents, alprenolol, propranolol and practolol were given as a prophylactic measure to patients undergoing middle-ear microsurgery where adrenaline was deli... | [
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PMID:26160 | Cardiovascular effects of local adrenaline infiltration during neurolept analgesia and adrenergic beta-receptor blockade in man. | The adrenergic beta-receptor blocking drug, alprenolol, was given together with atropine to 15 patients during neurolept analgesia (NLA) in order to prevent adrenaline-induced cardiac arrhythmias. Four patients operated on without adrenergic beta-receptor blockade formed the control group. Three of them developed tachy... | Cardiovascular effects of local adrenaline infiltration during neurolept analgesia and adrenergic beta-receptor blockade in man. The adrenergic beta-receptor blocking drug, alprenolol, was given together with atropine to 15 patients during neurolept analgesia (NLA) in order to prevent adrenaline-induced cardiac arrhyth... | [
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PMID:26162 | Qualitative differences between beta-adrenergic and alpha-adrenergic inotropic effects in rat heart muscle. | If beta- and alpha-adrenergic inotropic effects are cyclic AMP dependent and cyclic AMP independent, respectively, they may be qualitatively different. The inotropic effects of beta-receptor stimulation (isoprenaline) and alpha-receptor stimulation (phenylephrine combined with propranolol) were characterized in isolate... | Qualitative differences between beta-adrenergic and alpha-adrenergic inotropic effects in rat heart muscle. If beta- and alpha-adrenergic inotropic effects are cyclic AMP dependent and cyclic AMP independent, respectively, they may be qualitatively different. The inotropic effects of beta-receptor stimulation (isoprena... | [
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PMID:26163 | The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. | The effect of nifedipine (BAY 1040), a calcium-antagonistic inhibitor of the electromechanical coupling process was tested on atrioventricular conduction and refractoriness of the dog heart in situ by means of His-bundle electrography and programmed electrical stimulation. The animals were anaesthetized with sodium pen... | The effect of nifedipine on the sinus and atrioventricular node of the dog heart after beta-adrenergic receptor blockade. The effect of nifedipine (BAY 1040), a calcium-antagonistic inhibitor of the electromechanical coupling process was tested on atrioventricular conduction and refractoriness of the dog heart in situ ... | [
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PMID:26164 | Myocardial effects of lithium in vitro. | The myocardial effects of increasing concentrations of ionic lithium were investigated in isolated, spontaneously beating rabbit hearts, which were retrogradely perfused with a modified Krebs-Henseleit solution containing lithium in concentration of 1, 5 or 10 mM. The following functional parameters were continuously r... | Myocardial effects of lithium in vitro. The myocardial effects of increasing concentrations of ionic lithium were investigated in isolated, spontaneously beating rabbit hearts, which were retrogradely perfused with a modified Krebs-Henseleit solution containing lithium in concentration of 1, 5 or 10 mM. The following f... | [
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PMID:26161 | [Quantitative hyperpnea in EEG (author's transl)]. | After summarizing the phenomena of respiratory physiology involved in the hyperpnea test, the author studies the quantitative relation between the drop in PECO2 (pressure of CO2 in expired air) and changes in the EEG during hyperpnea. Normal subjects are divided into two groups of a hundred (6 to 19 1/2 years of age; 2... | [Quantitative hyperpnea in EEG (author's transl)]. After summarizing the phenomena of respiratory physiology involved in the hyperpnea test, the author studies the quantitative relation between the drop in PECO2 (pressure of CO2 in expired air) and changes in the EEG during hyperpnea. Normal subjects are divided into t... | [
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PMID:26166 | Comparison of beta-adrenoceptors mediating vasodilatation in canine subcutaneous adipose tissue and skeletal muscle. | Blood flow changes in response to various drugs in simulataneously autoperfused canine subcutaneous adipose tissue and gracilis muscle were compared to study the vascular beta-adrenoceptors. Compared to isoprenaline the beta 2-selective agonist salbutamol was 4--6 times more potent as a vasodilator in the muscle than i... | Comparison of beta-adrenoceptors mediating vasodilatation in canine subcutaneous adipose tissue and skeletal muscle. Blood flow changes in response to various drugs in simulataneously autoperfused canine subcutaneous adipose tissue and gracilis muscle were compared to study the vascular beta-adrenoceptors. Compared to ... | [
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PMID:26168 | Proton translocating ATPase: its pump, gate, and channel. | Proton translocating ATPase of oxidative phosphorylation was divided into three functional units: pump, channel, and gate. This was achieved by the use of highly stable pure ATPase obtained from a thermophilic bacterium PS3. The pump and gate were found in a catalytic moiety of the ATPase called TF1, and the channel wa... | Proton translocating ATPase: its pump, gate, and channel. Proton translocating ATPase of oxidative phosphorylation was divided into three functional units: pump, channel, and gate. This was achieved by the use of highly stable pure ATPase obtained from a thermophilic bacterium PS3. The pump and gate were found in a cat... | [
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PMID:26165 | Role of serotonin in the regulation of respiratory system function. | Role of serotonin in the regulation of respiratory system function. Acta Physiol. Pol., 1978, 29 (2): 131--138. This study examined respiratory centre reflector excitability, the electrical activity of respiratory muscles, outer breathing, pH and arterial blood gas composition under conditions of experimentally induced... | Role of serotonin in the regulation of respiratory system function. Role of serotonin in the regulation of respiratory system function. Acta Physiol. Pol., 1978, 29 (2): 131--138. This study examined respiratory centre reflector excitability, the electrical activity of respiratory muscles, outer breathing, pH and arter... | [
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PMID:26174 | Increased hemoglobin-oxygen affinity in patients with pancreatitis associated with type I and V hyperlipoproteinemia. | Oxyhemoglobin dissociation curves were performed from blood of subjects with pancreatitis associated with Type V and Type I hyperlipoproteinemia. The hemoglobin-oxygen affininty was markedly increased with P50 varying from 22.3 to 17.7 mmHg. As the hyperlipoproteinemia subsided the clinical and laboratory signs of panc... | Increased hemoglobin-oxygen affinity in patients with pancreatitis associated with type I and V hyperlipoproteinemia. Oxyhemoglobin dissociation curves were performed from blood of subjects with pancreatitis associated with Type V and Type I hyperlipoproteinemia. The hemoglobin-oxygen affininty was markedly increased w... | [
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PMID:26182 | Disturbances of extracellular pK, pNa and pH during no-flow anoxia. | The initial period of no-flow anoxia can be divided in at least two parts. During the first period lasting approximately 1 min., the O2 available in tissue gives rise to CO2 which increases hydrogen ion activity and may lead to Na+ influx2 (presumably due to increased membrane permeability to Na+). In the second perio... | Disturbances of extracellular pK, pNa and pH during no-flow anoxia. The initial period of no-flow anoxia can be divided in at least two parts. During the first period lasting approximately 1 min., the O2 available in tissue gives rise to CO2 which increases hydrogen ion activity and may lead to Na+ influx2 (presumably ... | [
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PMID:26185 | Skeletal muscle PO2: indicator of peripheral tissue perfusion in haemorrhagic shock. | The following conclusions can be made on the basis of this work: 1) Measurements of skeletal muscle oxygen tension provide an excellent index of tissue perfusion in haemorrhagic shock. 2) Correction of cardiac output and arterial blood oxygen tension in haemorrhagic shock does not necessarily ensure normal tissue oxyge... | Skeletal muscle PO2: indicator of peripheral tissue perfusion in haemorrhagic shock. The following conclusions can be made on the basis of this work: 1) Measurements of skeletal muscle oxygen tension provide an excellent index of tissue perfusion in haemorrhagic shock. 2) Correction of cardiac output and arterial blood... | [
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PMID:26195 | Pyrimidine nucleotide synthesis in rat embryo cells infected with X14 or H-1 parvovirus. | The activity of some enzymes involved in pyrimidine nucleotide synthesis was studied in rat embryo cell (REC) cultures infected with X14 or H-1 parvovirus. dCMP aminohydrolase activity of the infected cells was 64--121% greater than that of the mock-infected cells. dTMP synthetase activity was 18% greater in X14 virus-... | Pyrimidine nucleotide synthesis in rat embryo cells infected with X14 or H-1 parvovirus. The activity of some enzymes involved in pyrimidine nucleotide synthesis was studied in rat embryo cell (REC) cultures infected with X14 or H-1 parvovirus. dCMP aminohydrolase activity of the infected cells was 64--121% greater tha... | [
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PMID:26196 | Increased susceptibility to infection with herpes simplex virus types 1 and 2 of cold-adapted L cells. | L cells (L-As subline) have been adapted to a temperature of 4 degrees C. In the cold-adapted cells, designated LC3, greater amounts of infectious herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were synthesized than in the original L-As cells or in another control L-cell line. Two strains of HSV-1 reached higher in... | Increased susceptibility to infection with herpes simplex virus types 1 and 2 of cold-adapted L cells. L cells (L-As subline) have been adapted to a temperature of 4 degrees C. In the cold-adapted cells, designated LC3, greater amounts of infectious herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) were synthesized th... | [
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PMID:26197 | CV-1 monkey kidney cell line -- a highly susceptible substrate for diagnosis and study of arboviruses. | The CV-1 cell line, derived from Cercopithecus aethiops monkey kidneys, acquired in the course of serial passaging an epitheloid morphology and heteroploid karyotype. As compared with Vero and GMK cell lines, the CV-1 line proved to be more susceptible to a broad spectrum of arboviruses belonging to the families Togavi... | CV-1 monkey kidney cell line -- a highly susceptible substrate for diagnosis and study of arboviruses. The CV-1 cell line, derived from Cercopithecus aethiops monkey kidneys, acquired in the course of serial passaging an epitheloid morphology and heteroploid karyotype. As compared with Vero and GMK cell lines, the CV-1... | [
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PMID:26198 | Long-term persistence of cell-mediated and humoral immune response in specifically resistant mice given live attenuated langat (E5 "14") virus. | In a long-term experiment, the features of humoral and cell-mediated immunity (CMI) were investigated in mice given intravenously (i.v.) a single dose of live attenuated Langat (E5 "14") virus of the tick-borne encephalitis (TBE) complex. The inapparent infection induced in mice specific resistance against challenge wi... | Long-term persistence of cell-mediated and humoral immune response in specifically resistant mice given live attenuated langat (E5 "14") virus. In a long-term experiment, the features of humoral and cell-mediated immunity (CMI) were investigated in mice given intravenously (i.v.) a single dose of live attenuated Langat... | [
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PMID:26199 | Attenuated variants of eastern equine encephalomyelitis virus: pathomorphological, immunofluorescence and virological studies of infection in Syrian hamsters. | A virulent strain of eastern equine encephalomyelitis virus produced in hamsters a lethal infection with severe lesions of nerve cells predominatly in the anterior parts of the brain. Parenchyma necroses occurred in the liver and lymphoid organs. Infectious virus and viral antigen were found in all the organs examined ... | Attenuated variants of eastern equine encephalomyelitis virus: pathomorphological, immunofluorescence and virological studies of infection in Syrian hamsters. A virulent strain of eastern equine encephalomyelitis virus produced in hamsters a lethal infection with severe lesions of nerve cells predominatly in the anteri... | [
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PMID:26200 | Transmissible virus dementia. I. An unusual space and time clustering of Creutzfeldt-Jakob disease and of other organic presenile dementia cases. | A peculiar grouping of Creutzfeldt-Jacob disease (CJD) and of other organic presenile dementia (OPD) cases in a small, prevalently rural area in Czechoslovakia to the east of 19 degrees 35' E and to the north of 48 degrees 15' N was studied. Between August, 1972 and November, 1976, three histologically proven CJD cases... | Transmissible virus dementia. I. An unusual space and time clustering of Creutzfeldt-Jakob disease and of other organic presenile dementia cases. A peculiar grouping of Creutzfeldt-Jacob disease (CJD) and of other organic presenile dementia (OPD) cases in a small, prevalently rural area in Czechoslovakia to the east of... | [
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PMID:26201 | Transmissible virus dementia. II. Neurohistology of three, geographically clustered cases of Creutzfeldt-Jakob disease. | Histopathological findings in three temporo-spatially linked cases of Creutzfeldt-Jakob disease (CJD) are reported. The patients were males, unrelated and without positive family history. Their mean age at the onset of the disease was 52.3 years. The mean duration of the illness was 6.6 months; the clinical symptomatol... | Transmissible virus dementia. II. Neurohistology of three, geographically clustered cases of Creutzfeldt-Jakob disease. Histopathological findings in three temporo-spatially linked cases of Creutzfeldt-Jakob disease (CJD) are reported. The patients were males, unrelated and without positive family history. Their mean a... | [
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PMID:26202 | Comparative studies on sindbis virus strains isolated in Slovakia. | Two variants of Sindbis virus strains were distinguished according to the dextran sulphate (DS) marker. Large-plague strains freshly isolated from Cricetus cricetus and Rana ridibunda produced exclusively small plaques after DS treatment. The prototype Sindbis virus strain produced both large and small plaques after DS... | Comparative studies on sindbis virus strains isolated in Slovakia. Two variants of Sindbis virus strains were distinguished according to the dextran sulphate (DS) marker. Large-plague strains freshly isolated from Cricetus cricetus and Rana ridibunda produced exclusively small plaques after DS treatment. The prototype ... | [
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PMID:26203 | T lymphocytes as an indicator in influenza vaccination, influenza and acute respiratory diseases. | Significant differences in T-lymphocyte counts in the peripheral blood of normal subject and volunteers vaccinated with live and inactivated influenza vaccines as well as patients with influenza and viral acute respiratory diseases (ARD) were demonstrated. A laboratory test using T lymphocytes was proposed for the eval... | T lymphocytes as an indicator in influenza vaccination, influenza and acute respiratory diseases. Significant differences in T-lymphocyte counts in the peripheral blood of normal subject and volunteers vaccinated with live and inactivated influenza vaccines as well as patients with influenza and viral acute respiratory... | [
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PMID:26208 | Temperature-sensitive mutants of vaccinia virus. I. Isolation and preliminary characterization. | Fifty-seven temperature-sensitive (ts) mutants of a neurotropic variant of vaccinia virus were obtained. A comparison of the effectiveness of 6 different mutagens showed that in in vivo experiments nitrosomethylurea induced 10%, nitrosoguanidine 8%, and bromodeoxyuridine 2.5% ts mutants. In vitro, at the same degree of... | Temperature-sensitive mutants of vaccinia virus. I. Isolation and preliminary characterization. Fifty-seven temperature-sensitive (ts) mutants of a neurotropic variant of vaccinia virus were obtained. A comparison of the effectiveness of 6 different mutagens showed that in in vivo experiments nitrosomethylurea induced ... | [
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PMID:26209 | Pseudotype particles of vesicular stomatitis virus with surface antigens of bovine leukaemia virus--VSV (BLV) -- as a sensitive probe for detecting antibodies in the sera of spontaneously infected cattle. | Phenotypically mixed particles containing the genome of vesicular stomatitis virus (VSV) and envelope antigen corresponding to bovine leukaemia virus (BLV) -- the VSV (BLV) pseudotypes -- can be employed as a rapid, specific and sensitive probe for detecting BLV-neutralizing antibodies in bovine sera. | Pseudotype particles of vesicular stomatitis virus with surface antigens of bovine leukaemia virus--VSV (BLV) -- as a sensitive probe for detecting antibodies in the sera of spontaneously infected cattle. Phenotypically mixed particles containing the genome of vesicular stomatitis virus (VSV) and envelope antigen corre... | [
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PMID:26210 | Comparative study of virion transcriptase of some influenza virus strains. | The activities, the temperature and pH optima of in vitro functioning and stability upon heating of virion transcriptase of 10 human influenza virus A strains differing in reactogenicity and isolated in different epidemiological situations, and of fowl plague virus (FVP) were compared. As compared with virion transcrip... | Comparative study of virion transcriptase of some influenza virus strains. The activities, the temperature and pH optima of in vitro functioning and stability upon heating of virion transcriptase of 10 human influenza virus A strains differing in reactogenicity and isolated in different epidemiological situations, and ... | [
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PMID:26212 | The benzodiazepines. | The benzodiazepines are remarkably effective anxiolytic drugs. However, they are prone to misuse by both physicians and patients. They should be used in clearly defined clinical situations for short periods, at the lowest possible dosages. Although rare, toxicity can be severe. These agents should be used with caution ... | The benzodiazepines. The benzodiazepines are remarkably effective anxiolytic drugs. However, they are prone to misuse by both physicians and patients. They should be used in clearly defined clinical situations for short periods, at the lowest possible dosages. Although rare, toxicity can be severe. These agents should ... | [
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PMID:26213 | Non-specific aorto-arteritis in Singapore with special reference to hypertension. | Aorto-arteritis has recently emerged as a distinct disease entity with involvement of aorta and its major branches by a non-specific inflammation of unknown etiology. Though the distribution of this disease is worldwide, it is more prevalent in Japan, India, and South-east Asia. This paper describes a series of 48 case... | Non-specific aorto-arteritis in Singapore with special reference to hypertension. Aorto-arteritis has recently emerged as a distinct disease entity with involvement of aorta and its major branches by a non-specific inflammation of unknown etiology. Though the distribution of this disease is worldwide, it is more preval... | [
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PMID:26214 | Involvement of the cardiac conducting system in panarteritis nodosa. | Histopathological observations on the conduction system of the heart were carried out in three cases of panarteritis nodosa. This specialized tissue was involved in each case secondary to ischemia and/or periarterial extension of the inflammatory process affecting the nutrient arteries of the conducting system. The hig... | Involvement of the cardiac conducting system in panarteritis nodosa. Histopathological observations on the conduction system of the heart were carried out in three cases of panarteritis nodosa. This specialized tissue was involved in each case secondary to ischemia and/or periarterial extension of the inflammatory proc... | [
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PMID:26219 | Drug therapy in the treatment of minimal brain dysfunction. | The pharmacotherapy of minimal brain dysfunction (MBD) is reviewed. Studies using central nervous system (CNS) stimulants (amphetamines and methylphenidate, deanol, pemoline, caffeine), antidepressants (imipramine and desipramine), anticonvulsants (phenytoin and primidone), antianxiety agents (chlordiazepoxide, hydroxy... | Drug therapy in the treatment of minimal brain dysfunction. The pharmacotherapy of minimal brain dysfunction (MBD) is reviewed. Studies using central nervous system (CNS) stimulants (amphetamines and methylphenidate, deanol, pemoline, caffeine), antidepressants (imipramine and desipramine), anticonvulsants (phenytoin a... | [
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PMID:26220 | Acidosis of synovial fluid correlates with synovial fluid leukocytosis. | The antibacterial activity of aminoglycoside antibiotics is significantly reduced by lowering the pH of the incubation medium. Since gram-negative septic arthritis responds poorly to aminoglycoside antibiotic therapy, we sought to determine whether synovial fluid acidosis contributes to this poor outcome. Synovial flui... | Acidosis of synovial fluid correlates with synovial fluid leukocytosis. The antibacterial activity of aminoglycoside antibiotics is significantly reduced by lowering the pH of the incubation medium. Since gram-negative septic arthritis responds poorly to aminoglycoside antibiotic therapy, we sought to determine whether... | [
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PMID:26221 | Chronic cutaneous graft-versus-host disease in man. | This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoadenitis and the neurologic findings. Chronic cutaneous ... | Chronic cutaneous graft-versus-host disease in man. This clinicopathologic study of patients with chronic graft-versus-host disease (GVHD) after allogeneic marrow transplantation emphasizes the most prominent feature of the syndrome, the cutaneous aspects, and describes the ophthalmic-oral sicca syndrome with sialoaden... | [
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PMID:26222 | Hypnosis and related clinical behavior. | The essential aspect in the experience of the hypnotized person is the altered or distorted perception that is suggested to him. Not all people are capable of the experience, but it is possible that spontaneous distortions occur in those with high hypnotizability. These distortions are frequently experienced as frighte... | Hypnosis and related clinical behavior. The essential aspect in the experience of the hypnotized person is the altered or distorted perception that is suggested to him. Not all people are capable of the experience, but it is possible that spontaneous distortions occur in those with high hypnotizability. These distortio... | [
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PMID:26223 | Drug use by the polysurgical patient. | The authors compared the drug use of 23 patients with 5 or more major surgeries (mean number of surgeries = 9.8) with that of a matched control group (mean number of surgeries = 1). Total drug use of the polysurgical patients was 3.7 times greater than that of the controls and involved narcotics, analgesics, barbiturat... | Drug use by the polysurgical patient. The authors compared the drug use of 23 patients with 5 or more major surgeries (mean number of surgeries = 9.8) with that of a matched control group (mean number of surgeries = 1). Total drug use of the polysurgical patients was 3.7 times greater than that of the controls and invo... | [
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PMID:26224 | The treatment of severely depressed schizophrenic patients. | The diagnosis and treatment of severe masked depression in schizophrenia is discussed, and the difficulties in management are stressed, with particular reference to drug therapy, E.C.T., and psychotherapy. | The treatment of severely depressed schizophrenic patients. The diagnosis and treatment of severe masked depression in schizophrenia is discussed, and the difficulties in management are stressed, with particular reference to drug therapy, E.C.T., and psychotherapy. | [
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PMID:26225 | [Investigations on the plasm amino acids of old patients with rheumatoid arthritis (author's transl)]. | The amino acids of blood plasma of 43 patients with rheumatoid arthritis (RA) and 19 controls were investigated by ion exchange chromatography. It was proofed simultaneously whether human more than 60 years old exhibit significantly different amino acid concentrations from younger individuals. It was found that RA pati... | [Investigations on the plasm amino acids of old patients with rheumatoid arthritis (author's transl)]. The amino acids of blood plasma of 43 patients with rheumatoid arthritis (RA) and 19 controls were investigated by ion exchange chromatography. It was proofed simultaneously whether human more than 60 years old exhibi... | [
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PMID:26226 | [DNA--"rejoining" in lymphycytes of patients with a minifestation of rheumatoid arthritis in older age (author's transl)]. | Relations between the time of manifestation of the disease and the course of the rheumatoid arthritis were found from the clinic frequently. Patients with later first manifestation of rheumatoid arthritis show clear differences against patients with earlier manifestation of the disease at which the late first manifesta... | [DNA--"rejoining" in lymphycytes of patients with a minifestation of rheumatoid arthritis in older age (author's transl)]. Relations between the time of manifestation of the disease and the course of the rheumatoid arthritis were found from the clinic frequently. Patients with later first manifestation of rheumatoid ar... | [
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PMID:26227 | [Unexplained accelerated blood cells sedimentation rate in the aged (author's transl)]. | There is one reason for unexplained accelerated blood cells sedimentation rate in the aged, which is often neglected:Polymyalgia arteriitica or Arteriitis temporalis. Long-term therapy with cortison normalizes pains and sedimentation rate. Nevertheless, short-term treatment is a way to diagnose the disease "ex juvantib... | [Unexplained accelerated blood cells sedimentation rate in the aged (author's transl)]. There is one reason for unexplained accelerated blood cells sedimentation rate in the aged, which is often neglected:Polymyalgia arteriitica or Arteriitis temporalis. Long-term therapy with cortison normalizes pains and sedimentatio... | [
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PMID:26228 | [Interactions of drugs, used in the treatment of rheumatism in the elderly (author's transl)]. | This paper reviews the possibilities of interactions of drugs, used in the treatment of rheumatism in the elderly. Exspecially glycosides, antikoagulants, diuretics, uricosurics, salicylates, barbiturates and corticosteroides are discussed. | [Interactions of drugs, used in the treatment of rheumatism in the elderly (author's transl)]. This paper reviews the possibilities of interactions of drugs, used in the treatment of rheumatism in the elderly. Exspecially glycosides, antikoagulants, diuretics, uricosurics, salicylates, barbiturates and corticosteroides... | [
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PMID:26229 | [Scleroderma, an ageing process? I. Clinical and immunological aspects (author's transl)]. | Scleroderma with its different manifestations is mainly a disease of connective tissue and of vascular system. Next the alteration to collagen, which is demonstrable in lesions by decrease of embryonale collagen type III, there are also humoral and cellular phenomens of autoimmunity. In more than 70% of our patients we... | [Scleroderma, an ageing process? I. Clinical and immunological aspects (author's transl)]. Scleroderma with its different manifestations is mainly a disease of connective tissue and of vascular system. Next the alteration to collagen, which is demonstrable in lesions by decrease of embryonale collagen type III, there a... | [
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PMID:26230 | [The total alloplasty of the hip in very aged people (author's transl)]. | By means of a short follow-up study about all patients of more than eighty years of age, who had done a total alloplasty of the hip in the BG-Unfallklinik Ludwigshafen/Rhein, this is a report of the problems of surgery in the very aged people, the indication of surgery, the pre- and postoperative management and further... | [The total alloplasty of the hip in very aged people (author's transl)]. By means of a short follow-up study about all patients of more than eighty years of age, who had done a total alloplasty of the hip in the BG-Unfallklinik Ludwigshafen/Rhein, this is a report of the problems of surgery in the very aged people, the... | [
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PMID:26231 | [Age and time of hospitalization (author's transl)]. | A reduction of the time of hospitalization has been repeatedly considered as a cost-saving possibility in the projects of reforming the hospital system. The time of hospitalization of older patients is longer than that of younger patients. Every plan to reduce it fails for lack of flanking institutions, such as geriatr... | [Age and time of hospitalization (author's transl)]. A reduction of the time of hospitalization has been repeatedly considered as a cost-saving possibility in the projects of reforming the hospital system. The time of hospitalization of older patients is longer than that of younger patients. Every plan to reduce it fai... | [
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PMID:26232 | [Suicides in patients of a geriatric hospital (author's transl)]. | Problems of suicide during treatment in an internal geriatric hospital are discussed. Particular attention is given to possibilities of preventation. | [Suicides in patients of a geriatric hospital (author's transl)]. Problems of suicide during treatment in an internal geriatric hospital are discussed. Particular attention is given to possibilities of preventation. | [
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PMID:26233 | [Cause and incidence of suicides and attempted suicides by patients over 65 years old in psychiatric hospitals (author's transl)]. | Case reports of 184 suicides and attempted suicides in the six hospitals of the Landschaftsverband Rheinland from 1964-1974 were analyzed. 25 patients were over 65 years old. The combination of almost 30 variables revealed no significant constellation caused by old age. Furthermore no criterias could be found to assess... | [Cause and incidence of suicides and attempted suicides by patients over 65 years old in psychiatric hospitals (author's transl)]. Case reports of 184 suicides and attempted suicides in the six hospitals of the Landschaftsverband Rheinland from 1964-1974 were analyzed. 25 patients were over 65 years old. The combinatio... | [
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PMID:26234 | [Historical aspects of suicide in the old age (author's transl)]. | Beginning with a very different attitude of the antiquity taken up to suicide, which was normally not regarded as a self-murdering but as a voluntary departing this life and as such as a philosophically based act of liberty especially by members of the stoic system who not seldom commited suicide themselves, another es... | [Historical aspects of suicide in the old age (author's transl)]. Beginning with a very different attitude of the antiquity taken up to suicide, which was normally not regarded as a self-murdering but as a voluntary departing this life and as such as a philosophically based act of liberty especially by members of the s... | [
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PMID:26235 | [Causes, motivations and tendencies of suicidal acts in old age (author's transl)]. | The conditioning problems of suicidal acts of aged people were described by demonstrating the results of investigations in 125 patients (over 65 years). The control group consisted of 3004 suicidal patients below 65 years. Depression has been the prevailing psychiatric diagnosis (50% in contrast to 33% in the control g... | [Causes, motivations and tendencies of suicidal acts in old age (author's transl)]. The conditioning problems of suicidal acts of aged people were described by demonstrating the results of investigations in 125 patients (over 65 years). The control group consisted of 3004 suicidal patients below 65 years. Depression ha... | [
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PMID:26236 | [Social psychological aspects of suicide in the old age (author's transl)]. | Referring to Emile Durkheim's classical appraoch the normative aspects of suicide are emphasized, regarding suicidal behavior not as a purely individual phenomenon but as always co-determined by the normative expectations of a person's social environment. Starting from the dramatic increase of suicide rates with age co... | [Social psychological aspects of suicide in the old age (author's transl)]. Referring to Emile Durkheim's classical appraoch the normative aspects of suicide are emphasized, regarding suicidal behavior not as a purely individual phenomenon but as always co-determined by the normative expectations of a person's social e... | [
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PMID:26237 | [Isolation, loneliness and suicidal ideas in the aged (author's transl)]. | The relationship between various dimensions of social isolation, loneliness and suicidal ideas among a group of 406 respondents over 65 years of age were analyzed. The survey findings show that suicidal ideas emerge as a result of both, a loss of or a social denial to intimate and highly valued personal relationships. ... | [Isolation, loneliness and suicidal ideas in the aged (author's transl)]. The relationship between various dimensions of social isolation, loneliness and suicidal ideas among a group of 406 respondents over 65 years of age were analyzed. The survey findings show that suicidal ideas emerge as a result of both, a loss of... | [
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PMID:26239 | [Trends in modern international gerontological research. Experimental aspects]. | In a personal statement the author takes the view that gerontology and geriatrics deal with the same fundamental biological phenomenon, namely loss of adaptability and of the capacity to maintain the parameters of homeostasis. Two focal points of recent research in gerontology are cell cultures and the central nervous ... | [Trends in modern international gerontological research. Experimental aspects]. In a personal statement the author takes the view that gerontology and geriatrics deal with the same fundamental biological phenomenon, namely loss of adaptability and of the capacity to maintain the parameters of homeostasis. Two focal poi... | [
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PMID:26240 | [Trends in modern international gerontological research. Epidemiological aspects]. | Using the methods of comparing statistical data from the population in different countries on should have in mind that the age distribution could differ very much according to her biological and social structure. As example serves the system of social indicators applied by several supranational bodies in order to devel... | [Trends in modern international gerontological research. Epidemiological aspects]. Using the methods of comparing statistical data from the population in different countries on should have in mind that the age distribution could differ very much according to her biological and social structure. As example serves the sy... | [
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PMID:26241 | [Trends in modern international gerontological research. Psychological aspects]. | The present paper is based on the analysis of congress reports and gerontological journals and points up new trends in gerontological research. Quantitatively, there was an increase in the number of psycho-gerontological publications. However, relatively seen, they represent an almost unchanged percentage of the contri... | [Trends in modern international gerontological research. Psychological aspects]. The present paper is based on the analysis of congress reports and gerontological journals and points up new trends in gerontological research. Quantitatively, there was an increase in the number of psycho-gerontological publications. Howe... | [
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PMID:26242 | [Trends in modern international gerontological research. Sociological aspects]. | Some new trends of the following theoretical models of the sociology of aging are discussed: 1. Models of life cycle which allow a clearer differentiation between the age groupings. 2. The logic of the scientific analysis and the lack of further analysis of the specific sociological content of the disengagement theory.... | [Trends in modern international gerontological research. Sociological aspects]. Some new trends of the following theoretical models of the sociology of aging are discussed: 1. Models of life cycle which allow a clearer differentiation between the age groupings. 2. The logic of the scientific analysis and the lack of fu... | [
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PMID:26243 | [Trends in modern international gerontological research. Psychiatric aspects]. | The author puts a survey of new books, book's contributions, and recurrent publications of Geropsychiatry in last years. Special extracts are engaged with epidemiological investigations, clinical and diagnostical factors of presenile and senile dementia, and longitudinal studies of depressive disorders and schizophreni... | [Trends in modern international gerontological research. Psychiatric aspects]. The author puts a survey of new books, book's contributions, and recurrent publications of Geropsychiatry in last years. Special extracts are engaged with epidemiological investigations, clinical and diagnostical factors of presenile and sen... | [
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PMID:26244 | [Trends in modern international gerontological research. Morphological aspects]. | Ageing develops during the whole life with differences on cells, tissues and organs, and begins if their capacities for adaptations and compensations decrease. Theories about ageing are insufficiently. That results from the further development of ageing research in morphology also. Parenchymal cells are reduced in all ... | [Trends in modern international gerontological research. Morphological aspects]. Ageing develops during the whole life with differences on cells, tissues and organs, and begins if their capacities for adaptations and compensations decrease. Theories about ageing are insufficiently. That results from the further develop... | [
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PMID:26245 | [Glucose absorption from the small intestine in rats of different ages (authors transl)]. | Glucose absorption from the ageing rat's small intestine was studied "in vivo" using the recirculation-perfusion method of Sheff and Smyth. Different initial concentrations were used and animals of various ages (6 mo., 12 mo. and more than 27 mo. old) tested for their glucose uptake from the total small intestine (incl... | [Glucose absorption from the small intestine in rats of different ages (authors transl)]. Glucose absorption from the ageing rat's small intestine was studied "in vivo" using the recirculation-perfusion method of Sheff and Smyth. Different initial concentrations were used and animals of various ages (6 mo., 12 mo. and ... | [
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PMID:26246 | Bone mineral content of the healthy aged. | Using Norland-Cameron photon-absorption technique, bone mineral content of 436 healthy aged was measured and compared with that of 198 healthy, aged 21-50. Bone mineral content of postmenopausal females decreased continuously with age and bone mineral content of males began to decrease at age over 70. Bone width and me... | Bone mineral content of the healthy aged. Using Norland-Cameron photon-absorption technique, bone mineral content of 436 healthy aged was measured and compared with that of 198 healthy, aged 21-50. Bone mineral content of postmenopausal females decreased continuously with age and bone mineral content of males began to ... | [
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PMID:26247 | Gerontological aspects of hyperostosis frontalis interna. | Authors discuss hyperostosis frontalis interna observed in a large number of aged persons, on the basis of age and sex distribution as well as its clinical and roentgenomorphological analysis. In various forms of the ossification of the frontal bone no significant difference was found between the localisation of hypero... | Gerontological aspects of hyperostosis frontalis interna. Authors discuss hyperostosis frontalis interna observed in a large number of aged persons, on the basis of age and sex distribution as well as its clinical and roentgenomorphological analysis. In various forms of the ossification of the frontal bone no significa... | [
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PMID:26248 | [Further data on the isolation of the aged (authors transl)]. | Author's studies performed on 100 aged persons over sixty revealed the factors which play a role in the decline of the interpersonal connections. From his results, he suggests two forms of the communication-decrease during senessence. One form is a factor of exogen origin, which comes into existence as a result of depr... | [Further data on the isolation of the aged (authors transl)]. Author's studies performed on 100 aged persons over sixty revealed the factors which play a role in the decline of the interpersonal connections. From his results, he suggests two forms of the communication-decrease during senessence. One form is a factor of... | [
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PMID:26249 | Immuno-electronmicroscopic studies after influenza vaccination of young and old individuals. | Authors examined the lymphocytes of young and old individuals after influenza vaccination. They stated that membrane bound surface IgG and IgM were detectable on the lymphocytes and occasionally on lymphoblasts in both the old and young age groups. In both age-groups intracytoplasmic tubulo-reticular structures (TRS) w... | Immuno-electronmicroscopic studies after influenza vaccination of young and old individuals. Authors examined the lymphocytes of young and old individuals after influenza vaccination. They stated that membrane bound surface IgG and IgM were detectable on the lymphocytes and occasionally on lymphoblasts in both the old ... | [
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PMID:26250 | Autoantibodies in aged individuals. | Authors determined in 282 individuals autoantibodies in 132 T and B lymphozytes. Theirs results were as follows: 1. The frequency of the presence of autoantibodies increases with age. 2. In the presence of autoantibodies the absolute T and B lymphocyte counts of aged persons markedly decrease; the absolute T and B lymp... | Autoantibodies in aged individuals. Authors determined in 282 individuals autoantibodies in 132 T and B lymphozytes. Theirs results were as follows: 1. The frequency of the presence of autoantibodies increases with age. 2. In the presence of autoantibodies the absolute T and B lymphocyte counts of aged persons markedly... | [
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PMID:26251 | Age-related change of the absolute number of IgG-, and IgM-bearing B-lymphocytes and T-lymphocytes in human peripheral blood following influenza vaccination. | The absolute number of IgG-, and IgM-bearing B lymphocytes and of T lymphocytes was determined in the peripheral blood of 12 old (over 60 years) and 11 young (20 to 40 years) healthy persons before vaccination and 6 days and 6 weeks, respectively after vaccination. It has been found that as opposed to an approximately ... | Age-related change of the absolute number of IgG-, and IgM-bearing B-lymphocytes and T-lymphocytes in human peripheral blood following influenza vaccination. The absolute number of IgG-, and IgM-bearing B lymphocytes and of T lymphocytes was determined in the peripheral blood of 12 old (over 60 years) and 11 young (20 ... | [
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PMID:26252 | Natural antibody level in old age. | Antibacterial antibodies were determined with a passive hemagglutination micromethod using the Boivin extract of eight different strains of bacteria. Correlation between antibody values of different specificities and between the summarized titer values and individual antibody titers were found. A significant decrease i... | Natural antibody level in old age. Antibacterial antibodies were determined with a passive hemagglutination micromethod using the Boivin extract of eight different strains of bacteria. Correlation between antibody values of different specificities and between the summarized titer values and individual antibody titers w... | [
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PMID:26253 | Influence of methyl xanthine treatment on calcitonin effect. | The presented results clearly demonstrate that theophylline, caffeine and theobromine have a blocking action on calcitonin effect as determined by the elevation of serum calcium level, although different degree of potency was found with each drugs. There is no difference in respect of the serum calcium elevation after ... | Influence of methyl xanthine treatment on calcitonin effect. The presented results clearly demonstrate that theophylline, caffeine and theobromine have a blocking action on calcitonin effect as determined by the elevation of serum calcium level, although different degree of potency was found with each drugs. There is n... | [
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PMID:26254 | [Survived brain infarction in old age - clinical and morphological findings. part I: extracranial stenoses of carotis arteries (author's transl)]. | By clinical and post mortem findings we searched for the risk factors, important for brain infarctions in people of nearly 80 years. We were especially interested in the conditions of the extracranial vessels such as the carotid arteries and the murmurs at this point. The number of arterial stenoses in this region, asc... | [Survived brain infarction in old age - clinical and morphological findings. part I: extracranial stenoses of carotis arteries (author's transl)]. By clinical and post mortem findings we searched for the risk factors, important for brain infarctions in people of nearly 80 years. We were especially interested in the con... | [
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PMID:26255 | [Iatrogenic depression in the aged (author's transl)]. | The increasing number of depressions, especially in old patients, is alarming. Partly these depressions, however, are avoidable since they are of iatrogenic origin. By the example of hormones, antihypertensives, antihistaminics, antirheumatics and even the psychotropic drugs themselves the attention of physicians shall... | [Iatrogenic depression in the aged (author's transl)]. The increasing number of depressions, especially in old patients, is alarming. Partly these depressions, however, are avoidable since they are of iatrogenic origin. By the example of hormones, antihypertensives, antihistaminics, antirheumatics and even the psychotr... | [
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PMID:26256 | [Laparoscopic findings in aged patients (author's transl)]. | A group of 165 geriatric patients is compared with a control group of 114 younger patients concerning different frequency of laparoscopic diagnoses. As it was suspected from the clinical view aged patients predominently suffered from posthepatic cirrhosis and from cirrhosis of unknown origin, from recurrent cholecystit... | [Laparoscopic findings in aged patients (author's transl)]. A group of 165 geriatric patients is compared with a control group of 114 younger patients concerning different frequency of laparoscopic diagnoses. As it was suspected from the clinical view aged patients predominently suffered from posthepatic cirrhosis and ... | [
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PMID:26257 | [Results of a comparing study concerning men under 40 years old and above 60 years, affected by myocardial infarction (author's transl)]. | We examined a group of 300 men in the age of under 40 and a comparing group of 300 men in the age of 60 and more years, with clinically or histologically ascertained heart infarct (according to criterions of (WHO). Our work brought the proof that clinically unambiguous heart-infarct in the group of men under 40 years w... | [Results of a comparing study concerning men under 40 years old and above 60 years, affected by myocardial infarction (author's transl)]. We examined a group of 300 men in the age of under 40 and a comparing group of 300 men in the age of 60 and more years, with clinically or histologically ascertained heart infarct (a... | [
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PMID:26258 | Infectious mononucleosis in the case of two elderly (80 and 57 years old age) patients. | There are reported two cases of infectious mononucleosis in elderly. In the first case (80 years; probably the oldest in the geriatric literature) the infection provoked a very serious illness and the patient deceased three months after dimission, because of diminished resistance. In the second case the mononucleosis i... | Infectious mononucleosis in the case of two elderly (80 and 57 years old age) patients. There are reported two cases of infectious mononucleosis in elderly. In the first case (80 years; probably the oldest in the geriatric literature) the infection provoked a very serious illness and the patient deceased three months a... | [
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PMID:26259 | [Results concerning the sensitivity of old patients against digitalis (author's transl)]. | It could be demonstrated that there was an age-dependent increase of digitalisintoxications in correlation with digitalisconcentrations in blood. This phenomenon can be explained with the frequently observed underweight in the senium. Some patients older than 70 years showed symptoms of intoxication in spite of a norma... | [Results concerning the sensitivity of old patients against digitalis (author's transl)]. It could be demonstrated that there was an age-dependent increase of digitalisintoxications in correlation with digitalisconcentrations in blood. This phenomenon can be explained with the frequently observed underweight in the sen... | [
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PMID:26260 | Treatment of painful osteoporosis with fluoride, calcium, and calciferol. | Fourteen women averaging 69.5 years of age with painful osteoporosis of the spine were treated with sodium fluoride, calcium salts and calciferol. At assessment after 5-19 months of therapy 8 patients were free of pains while in 5 women pains had decreased and mobility improved. One patient had unaltered pains. Side ef... | Treatment of painful osteoporosis with fluoride, calcium, and calciferol. Fourteen women averaging 69.5 years of age with painful osteoporosis of the spine were treated with sodium fluoride, calcium salts and calciferol. At assessment after 5-19 months of therapy 8 patients were free of pains while in 5 women pains had... | [
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PMID:26261 | [Age-related problems in the procedure of fibrinolytic treatment with streptokinase (author's transl)]. | 600 patients aged 24 to 78 were treated by streptokinase infusions. 38 patients were older and 562 patients younger than 65 years. Most indications of fibrinolytic therapy were chronic arterial occlusions and stenoses. The outcome of lytic treatment was dependent upon the occlusion's age, e.g., occlusions of 0--2 weeks... | [Age-related problems in the procedure of fibrinolytic treatment with streptokinase (author's transl)]. 600 patients aged 24 to 78 were treated by streptokinase infusions. 38 patients were older and 562 patients younger than 65 years. Most indications of fibrinolytic therapy were chronic arterial occlusions and stenose... | [
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PMID:26263 | [Problems in teaching gerontological facts to medical students (author's transl)]. | During the medical training the geriatric problems are still not observed enough, and they are not taken into consideration yet in the medical indexes for the different sections of the medical examination either. Geriatrics though, which have to be more extensive because of the multiplicity of the disease, can countera... | [Problems in teaching gerontological facts to medical students (author's transl)]. During the medical training the geriatric problems are still not observed enough, and they are not taken into consideration yet in the medical indexes for the different sections of the medical examination either. Geriatrics though, which... | [
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PMID:26264 | [Expectations of participants in gerontological in-service courses as a didactic problem (author's transl)]. | In planning and teaching gerontological inservice courses one has to take into account the fact that the participants are adult learners who have certain expectations and interests. In the present article typical expectations are discussed and didactic conclusions for the future organization of in-service courses are d... | [Expectations of participants in gerontological in-service courses as a didactic problem (author's transl)]. In planning and teaching gerontological inservice courses one has to take into account the fact that the participants are adult learners who have certain expectations and interests. In the present article typica... | [
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