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PMID:27094 | Granulomatous ileocolitis preceded by three years of pauciarticular arthritis. | The case of a 12-year old male is presented in whom pauciarticular arthritis preceded the clinical onset of granulomatous ileocolitis by three years. Before the onset of gastrointestinal symptoms, the patients' clinical diagnosis was juvenile rheumatoid arthritis. This case stresses the importance of including inflamma... | Granulomatous ileocolitis preceded by three years of pauciarticular arthritis. The case of a 12-year old male is presented in whom pauciarticular arthritis preceded the clinical onset of granulomatous ileocolitis by three years. Before the onset of gastrointestinal symptoms, the patients' clinical diagnosis was juvenil... | [
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PMID:27097 | The influence of maternal psychological stress on the fetus. | The effects of maternal agitation, induced by exposure to bright light, upon fetal well-being were studied in pregnant rhesus monkeys at 139 to 148 days of gestation. Fetuses were classified as "healthy" or "asphyxiated" according to their initial acid-base state. Following variable periods of maternal excitement, a de... | The influence of maternal psychological stress on the fetus. The effects of maternal agitation, induced by exposure to bright light, upon fetal well-being were studied in pregnant rhesus monkeys at 139 to 148 days of gestation. Fetuses were classified as "healthy" or "asphyxiated" according to their initial acid-base s... | [
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PMID:27099 | Gastric HCO3--secretion in the guinea pig. | Measurement of gastric intraluminal PCO2 and pH in the anesthetized guinea pig enabled simultaneous determination of total H+ and HCO3- gastric secretions. There was quantitative agreement between the release of CO2 and decrease in HCO3- after intragastric instillation of HCl. The basal rate of HCO3- secretion (approxi... | Gastric HCO3--secretion in the guinea pig. Measurement of gastric intraluminal PCO2 and pH in the anesthetized guinea pig enabled simultaneous determination of total H+ and HCO3- gastric secretions. There was quantitative agreement between the release of CO2 and decrease in HCO3- after intragastric instillation of HCl.... | [
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PMID:27100 | Acetylsalicylic acid hydrolase of gastric mucosa. | Acetylsalicylic acid hydrolase activity of rabbit fundic gastric mucosa has been isolated from the soluble 100,000 X g supernate. The enzymatic activity was partially purified by ammonium sulfate precipitation. The Km for acetylsalicylate was 2 mM and pH optimum was 8.6. The activity was insensitive to ionic strength, ... | Acetylsalicylic acid hydrolase of gastric mucosa. Acetylsalicylic acid hydrolase activity of rabbit fundic gastric mucosa has been isolated from the soluble 100,000 X g supernate. The enzymatic activity was partially purified by ammonium sulfate precipitation. The Km for acetylsalicylate was 2 mM and pH optimum was 8.6... | [
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PMID:27101 | Alterations of glucose metabolism during perfusion of rat lung with paraquat. | Isolated perfused rat lungs were used to investigate effects of paraquat on lung glucose metabolism. Lungs were ventilated with 5% CO2 in air and perfused with Krebs-Ringer bicarbonate buffer, pH 7.4, containing albumin and 5.5 mM radiolabeled D-glucose. Control lung glucose utilization, estimated from rate of 3H2O pro... | Alterations of glucose metabolism during perfusion of rat lung with paraquat. Isolated perfused rat lungs were used to investigate effects of paraquat on lung glucose metabolism. Lungs were ventilated with 5% CO2 in air and perfused with Krebs-Ringer bicarbonate buffer, pH 7.4, containing albumin and 5.5 mM radiolabele... | [
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PMID:27104 | Human platelet MAO in drug-free and medicated schizophrenic patients. | The authors compared platelet monoamine oxidase activity in drug-free chronic and acute schizophrenic patients, medicated chronic schizophrenic patients, and normal controls. A significant decrement in MAO activity was found only in medicated chronic schizophrenic patients. The possible mechanism for this finding is di... | Human platelet MAO in drug-free and medicated schizophrenic patients. The authors compared platelet monoamine oxidase activity in drug-free chronic and acute schizophrenic patients, medicated chronic schizophrenic patients, and normal controls. A significant decrement in MAO activity was found only in medicated chronic... | [
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PMID:27107 | [The importance of age dependent changes of the organism for therapy (author's transl)]. | Molecular and supramolecular mechanisms of ageing involve biochemical, physiological and morphological alterations of organs. Furthermore physiological disturbances are superimposed by pathological mechanisms of ageing. As a result the number of diseases in higher age increases as well as there are a lot of therapeutic... | [The importance of age dependent changes of the organism for therapy (author's transl)]. Molecular and supramolecular mechanisms of ageing involve biochemical, physiological and morphological alterations of organs. Furthermore physiological disturbances are superimposed by pathological mechanisms of ageing. As a result... | [
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PMID:27108 | [Contribution to wet and dry weights of mesenchymal and parenchymatous organs of humans and rats during the course of life (author's transl)]. | The wet and dry weights of parenchymatous (lung, heart, liver, kidney) and of mesenchymal organs (aorta, skin, xiphoid cartilage) of humans and rats (both sexes) were investigated during the course of life. Furthermore, these investigations were done on the following rat organs: brain (divided in cerebrum as well as in... | [Contribution to wet and dry weights of mesenchymal and parenchymatous organs of humans and rats during the course of life (author's transl)]. The wet and dry weights of parenchymatous (lung, heart, liver, kidney) and of mesenchymal organs (aorta, skin, xiphoid cartilage) of humans and rats (both sexes) were investigat... | [
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PMID:27109 | [Correlations between age, risk factors for arteriosclerosis and endocrine functions (author's transl)]. | In 377 males and 528 female factory workers basal serum levels of glucose, neutralfat, cholesterol, Na, K, Ca and LH, FSH, TSH, Prolactin, GH, Insulin, total corticoids and testosteron were determined. Mean values and standard deviations as well as correlations between mean basal hormone levels and other serum paramete... | [Correlations between age, risk factors for arteriosclerosis and endocrine functions (author's transl)]. In 377 males and 528 female factory workers basal serum levels of glucose, neutralfat, cholesterol, Na, K, Ca and LH, FSH, TSH, Prolactin, GH, Insulin, total corticoids and testosteron were determined. Mean values a... | [
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PMID:27110 | [Linguistics of ageing, linguistic Gerontology--Why? (author's transl)]. | Intercourse between the young and the old is accompanied by difficulties in finding the right word. Authentic observations will be presented. These every-day experiences have prompted the search for the felicity conditions of verbal interaction between members of different age groups. This concern is called linguistics... | [Linguistics of ageing, linguistic Gerontology--Why? (author's transl)]. Intercourse between the young and the old is accompanied by difficulties in finding the right word. Authentic observations will be presented. These every-day experiences have prompted the search for the felicity conditions of verbal interaction be... | [
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PMID:27111 | [On the social situation of sick old women (author's transl)]. | By explaining the social situation of the patients in a Berlin hospital for chronic and geriatric diseases, it is demonstrated that financial security and social status of old woman patients are much worse than those of old men. Examples are mentioned to demonstrate which were--and still are--the main causes--that in t... | [On the social situation of sick old women (author's transl)]. By explaining the social situation of the patients in a Berlin hospital for chronic and geriatric diseases, it is demonstrated that financial security and social status of old woman patients are much worse than those of old men. Examples are mentioned to de... | [
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PMID:27112 | [Analyses of space available in homes and day centers for the aged, as well as nursing homes for elderly people, in the FRG. Booking and occupation rate in homes and nursing homes for the aged (author's transl)]. | Further intention of the survey having been conducted to show the consequences of the "Heimmindestverordnung" (draft dated Nov. 1974) was to obtain a review of the density of occupancy related to housing for the elderly. In homes for the old the rate of one-bed-rooms significantly increased during the last 15 years, wh... | [Analyses of space available in homes and day centers for the aged, as well as nursing homes for elderly people, in the FRG. Booking and occupation rate in homes and nursing homes for the aged (author's transl)]. Further intention of the survey having been conducted to show the consequences of the "Heimmindestverordnun... | [
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PMID:27113 | [Consumer information activities in old age (author's transl)]. | The following feature occupies with consumer information activities in old age. These informations are partial results of a study that was carried out in the Institut für Sozialforschung und Gesellschaftspolitik in Cologne by order of the Arbeitsgemeinschaft der Verbraucher and which deals with chances of consumer poli... | [Consumer information activities in old age (author's transl)]. The following feature occupies with consumer information activities in old age. These informations are partial results of a study that was carried out in the Institut für Sozialforschung und Gesellschaftspolitik in Cologne by order of the Arbeitsgemeinscha... | [
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PMID:27114 | [Working conditions and job-requirement of older industrial blue collar workers and the consequences in employment problems (author's transl)]. | In the following passage the reduced vocational capacity of older workers will be discussed as a consequence of the intended high-capacity of workers as well as the non--human working--conditions in industry. The reduced personal sanity and working capacity of older workers point out the high rate of handicaps and the ... | [Working conditions and job-requirement of older industrial blue collar workers and the consequences in employment problems (author's transl)]. In the following passage the reduced vocational capacity of older workers will be discussed as a consequence of the intended high-capacity of workers as well as the non--human ... | [
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PMID:27115 | [The effects of the social security system on the life situation of old people (author's transl)]. | The situation of old people is determined by the system of Social Security in a various way. A point of most importance are effects of pensions etc. on the distribution of income. It is shown, that distribution of old-age pensions follows the same scheme, which is dominating in the distribution of primary income. This ... | [The effects of the social security system on the life situation of old people (author's transl)]. The situation of old people is determined by the system of Social Security in a various way. A point of most importance are effects of pensions etc. on the distribution of income. It is shown, that distribution of old-age... | [
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PMID:27116 | [Maintenance payments to the elderly (author's transl)]. | The question of the extent older people sustain their livelihood through financial contribution from their children is important sociopolitically inasmuch as claims for payments under the Federal Social Welfare Scheme (Bundessozialhilfegesetz) can only be made where no such private financial support can be given by tho... | [Maintenance payments to the elderly (author's transl)]. The question of the extent older people sustain their livelihood through financial contribution from their children is important sociopolitically inasmuch as claims for payments under the Federal Social Welfare Scheme (Bundessozialhilfegesetz) can only be made wh... | [
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PMID:27117 | [Measuring nursing needs of older people related to actual nursing time in institutions for the aged (author's transl)]. | A great many of the elderly people are in need of care. In offering services accordingly it is necessary to acquire relevant data. The following article gives results of a study which determined 1) the real amount of given nursing care and 2) the measured amount of nursing needs of these patients. The research was done... | [Measuring nursing needs of older people related to actual nursing time in institutions for the aged (author's transl)]. A great many of the elderly people are in need of care. In offering services accordingly it is necessary to acquire relevant data. The following article gives results of a study which determined 1) t... | [
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PMID:27118 | [Environment and selfsufficiency of elder man (author's transl)]. | The problems of environment of elderly people are concentrated in social area and in the intimate living space, which can not be maintained sufficiently because of increasing age and decreasing performance. The consequences of mobility in industrial revolution scattered families and also deprived old men of their helpe... | [Environment and selfsufficiency of elder man (author's transl)]. The problems of environment of elderly people are concentrated in social area and in the intimate living space, which can not be maintained sufficiently because of increasing age and decreasing performance. The consequences of mobility in industrial revo... | [
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PMID:27119 | [On postoperative azotemia in geriatric surgery: significance, risk groups, possibilities of prophylaxis (author's transl)]. | 1032 Interventions on geriatric patients beeing more than 70 years old between 1966 and 1975 demonstrate the significance of azotemia in the postoperativ stage of the disease appears as well as its dependence upon prehospital factors, type and localisation also on the extension and duration on the intervention in each ... | [On postoperative azotemia in geriatric surgery: significance, risk groups, possibilities of prophylaxis (author's transl)]. 1032 Interventions on geriatric patients beeing more than 70 years old between 1966 and 1975 demonstrate the significance of azotemia in the postoperativ stage of the disease appears as well as i... | [
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PMID:27120 | Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions. | The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurolept' combinations and four commonly-used premedicants. When given intravenously 10 min before induction... | Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions. The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied. These included three benzodiazepines, droperidol and 'neurol... | [
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PMID:27121 | Ketamine-iorazepam. Attenuation of psychic sequelae of ketamine by lorazepam. | The intravenous, intramuscular and oral administration of 4 mg lorazepam given to adults will effectively reduce the psychic sequelae of ketamine to acceptable limits. | Ketamine-iorazepam. Attenuation of psychic sequelae of ketamine by lorazepam. The intravenous, intramuscular and oral administration of 4 mg lorazepam given to adults will effectively reduce the psychic sequelae of ketamine to acceptable limits. | [
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PMID:27123 | [The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)]. | Reports on in vitro precipitation of local anesthetics suggested the possibility of a damaging effect on nervous tissue with spinal anesthesia. The present assays showed that the solubility of local anesthetics in aqueous media decreases with rising pH-levels. The partial pressure of CO2 determines the pH-level of the ... | [The solutibility of local anaesthetics in cerebrospinal fluid and the dependency of the process on the hydrogene ion concentration (author's transl)]. Reports on in vitro precipitation of local anesthetics suggested the possibility of a damaging effect on nervous tissue with spinal anesthesia. The present assays showe... | [
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PMID:27124 | [pH of the cerebro spinal fluid during subdural block (author's transl)]. | This study was initiated by other authors who found that bupivacaine precipitated together with spinal fluid in vitro and who assumed that during spinal anaesthesia complications might be possible. Under the influence of several local anaesthetic agents the pH of the spinal fluid and in 160 cases the precipitation was ... | [pH of the cerebro spinal fluid during subdural block (author's transl)]. This study was initiated by other authors who found that bupivacaine precipitated together with spinal fluid in vitro and who assumed that during spinal anaesthesia complications might be possible. Under the influence of several local anaesthetic... | [
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PMID:27127 | [Changes of circulation, blood gases, acid-base-and metabolism during neurolept-analgesia with and without beta-receptor blockers in electro coagulation of Gasser's ganglion (author's transl)]. | The cardiovascular, blood gas, acid-base and metabolic changes occurring during operative stress were studied in 10 elderly, metabolically healthy patients, suffering from idiopathic trigeminal neuralgia, who underwent electrocoagulation of the gasserian ganglion under neuroleptanalgesia. In a group of 12 patients unde... | [Changes of circulation, blood gases, acid-base-and metabolism during neurolept-analgesia with and without beta-receptor blockers in electro coagulation of Gasser's ganglion (author's transl)]. The cardiovascular, blood gas, acid-base and metabolic changes occurring during operative stress were studied in 10 elderly, m... | [
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PMID:27129 | Acid aspiration during laparoscopy. | The prophylactic efficacy of pre-operative antacid administration was shown by comparing the pH and volumes of gastric contents in 50 female patients treated with 10 ml of Mist. Magnesium Trisilicate B.P.C. with that of 50 controls. Routine antacid prophylaxis was advocated for all patients undergoing pelvic laparoscop... | Acid aspiration during laparoscopy. The prophylactic efficacy of pre-operative antacid administration was shown by comparing the pH and volumes of gastric contents in 50 female patients treated with 10 ml of Mist. Magnesium Trisilicate B.P.C. with that of 50 controls. Routine antacid prophylaxis was advocated for all p... | [
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PMID:27131 | Placental transfer of lidocaine: effects of fetal acidosis. | To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml. After maternal-fetal equilibrium was reached, the fetus was made acidotic by ... | Placental transfer of lidocaine: effects of fetal acidosis. To investigate whether fetal acidosis increases the placental transfer of lidocaine, resulting in higher fetal blood levels of the drug, lidocaine was infused intravenously into ten pregnant ewes to maintain plasma levels of 2-4 microgram/ml. After maternal-fe... | [
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PMID:27132 | Hemoglobin Creteil: oxygen transport by erythrocytes. In-vitro and in-vivo studies in a high oxygen-affinity mutant hemoglobin. | Hemoglobin Hb) Creteil alpha2beta(2)89 (F5) Ser leads to Asn is a high oxygen-affinity variant that has a low cooperativity, a decreased Bohr effect, and does not interact with diphosphoglycerate (DPG) (1). This hemoglobin variant was silent by routine electrophoresis. Careful analyses of the oxygen dissociation curves... | Hemoglobin Creteil: oxygen transport by erythrocytes. In-vitro and in-vivo studies in a high oxygen-affinity mutant hemoglobin. Hemoglobin Hb) Creteil alpha2beta(2)89 (F5) Ser leads to Asn is a high oxygen-affinity variant that has a low cooperativity, a decreased Bohr effect, and does not interact with diphosphoglycer... | [
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PMID:27134 | Cold injuries in Kashmir, December 1971. | A total of 847 cases of cold injury occurred within the short space of 2 weeks during the Indo-Pakistan conflict in Kashmir in December 1971. The management of these cases and their end results are described. A combination of drugs consisting of low-molecular-weight dextran, an anti-inflammatory agent, and a vasodilato... | Cold injuries in Kashmir, December 1971. A total of 847 cases of cold injury occurred within the short space of 2 weeks during the Indo-Pakistan conflict in Kashmir in December 1971. The management of these cases and their end results are described. A combination of drugs consisting of low-molecular-weight dextran, an ... | [
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PMID:27135 | A disorder of biogenic amines in dihydropteridine reductase deficiency. | A severe deficiency of dihydropteridine reductase (DHPR) in liver, brain, and cultured skin fibroblasts was demonstrated in a child with hyperphenylalaninemia and an atypical form of phenylketonuria. DHPR is required for regeneration of the cofactor, tetrahydrobiopterin. The cofactor is essential in hydroxylation of ar... | A disorder of biogenic amines in dihydropteridine reductase deficiency. A severe deficiency of dihydropteridine reductase (DHPR) in liver, brain, and cultured skin fibroblasts was demonstrated in a child with hyperphenylalaninemia and an atypical form of phenylketonuria. DHPR is required for regeneration of the cofacto... | [
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PMID:27137 | Stability of antibiotics and amino acids in two synthetic L-amino acid solutions commonly used for total parenteral nutrition in children. | The stability and interaction at 29 degrees C of ampicillin, carbenicillin, gentamicin, and polymyxin B were examined in a common electrolyte solution, invertose darrow, and in two synthetic l-amino acid solutions, one commercial (vamin with fructose; Vitrum) and the other a neonatal preparation modified for use in new... | Stability of antibiotics and amino acids in two synthetic L-amino acid solutions commonly used for total parenteral nutrition in children. The stability and interaction at 29 degrees C of ampicillin, carbenicillin, gentamicin, and polymyxin B were examined in a common electrolyte solution, invertose darrow, and in two ... | [
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PMID:27138 | Chloramphenicol resistance in Streptococcus pneumoniae: enzymatic acetylation and possible plasmid linkage. | Clinical isolates of Streptococcus pneumoniae resistant to chloramphenicol were observed in France for the first time in 1973. During a 4-year survey, these strains were found to represent 6% of a total of 564 isolates of S. pneumoniae in a general hospital and to belong to 13 different serotypes. One such strain, refe... | Chloramphenicol resistance in Streptococcus pneumoniae: enzymatic acetylation and possible plasmid linkage. Clinical isolates of Streptococcus pneumoniae resistant to chloramphenicol were observed in France for the first time in 1973. During a 4-year survey, these strains were found to represent 6% of a total of 564 is... | [
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PMID:27139 | Irreversible effects of serum proteins on beta-lactam antibiotics. | The chromogenic cephalosporin nitrocefin (87/312) demonstrates rapid and visible instability to serum from many species. This phenomenon was distinct from serum binding, being significantly slower. Destruction of another cephalosporin, 10485, by serum appeared to account for some anomalous results during investigation ... | Irreversible effects of serum proteins on beta-lactam antibiotics. The chromogenic cephalosporin nitrocefin (87/312) demonstrates rapid and visible instability to serum from many species. This phenomenon was distinct from serum binding, being significantly slower. Destruction of another cephalosporin, 10485, by serum a... | [
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PMID:27140 | Antimicrobial susceptibility patterns of Streptococcus pneumoniae. | Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated October 1961 through December 1964) were tested for susceptibility to ... | Antimicrobial susceptibility patterns of Streptococcus pneumoniae. Fifty clinical isolates of Streptococcus pneumoniae received by the Streptococcus Laboratory of the Center for Disease Control from August 1976 through March 1977 and 50 pneumococcal strains retrieved from 13- to 16-year storage (originally isolated Oct... | [
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PMID:27141 | Susceptibility of skin and throat strains of group A streptococci to rosamicin and erythromycin. | The minimal inhibitory concentrations of rosamicin and erythromycin were compared for 210 strains of group A streptococcus isolated from a diverse spectrum of streptococcal diseases. Of these strains, 97.6% were inhibited by 0.1 to 0.2 mug of rosamicin per ml, whereas 90.9% were inhibited by 0.025 to 0.05 mug of erythr... | Susceptibility of skin and throat strains of group A streptococci to rosamicin and erythromycin. The minimal inhibitory concentrations of rosamicin and erythromycin were compared for 210 strains of group A streptococcus isolated from a diverse spectrum of streptococcal diseases. Of these strains, 97.6% were inhibited b... | [
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PMID:27146 | The action of lecithin monolayers on mosquitoes I. General observations. | Monolayers of pure egg-lecithin at maximum equilibrium pressure were tested against eight species of mosquito in the laboratory, Anopheline larvae were prevented from surfacing and died in water of low dissolved oxygen content, but culicine larvae survived. The pupae of all species except Culex p. fatigans were killed.... | The action of lecithin monolayers on mosquitoes I. General observations. Monolayers of pure egg-lecithin at maximum equilibrium pressure were tested against eight species of mosquito in the laboratory, Anopheline larvae were prevented from surfacing and died in water of low dissolved oxygen content, but culicine larvae... | [
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PMID:27147 | The action of lecithin monolayers on mosquitoes. II. Action on the respiratory structures. | Experiments on the interaction between the water surface and the respiratory structures of larvae and pupae of five species of mosquitoes showed that in the presence of a lecithin monolayer, a stable, soap-bubble type film is formed which prevents the insect from surfacing. Subsequently, wetting of the hydrophobic area... | The action of lecithin monolayers on mosquitoes. II. Action on the respiratory structures. Experiments on the interaction between the water surface and the respiratory structures of larvae and pupae of five species of mosquitoes showed that in the presence of a lecithin monolayer, a stable, soap-bubble type film is for... | [
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PMID:27151 | Hypotensive action of beta-blocking drugs injected into the cerebral ventricle of the rat. | Pindolol, propranolol, practolol, N-isopropyl-p-nitrophenyl-ethanolamine (INPEA), d and l-alprenolol were injected into the lateral cerebral ventricle of the anaesthetized rat. Except for INPEA, which has no action at the doses used, these various beta-blocking agents produce a dose-related fall in blood pressure. D-al... | Hypotensive action of beta-blocking drugs injected into the cerebral ventricle of the rat. Pindolol, propranolol, practolol, N-isopropyl-p-nitrophenyl-ethanolamine (INPEA), d and l-alprenolol were injected into the lateral cerebral ventricle of the anaesthetized rat. Except for INPEA, which has no action at the doses u... | [
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PMID:27152 | Ganglion blocking effects of streptomycin. | The effects of streptomycin on the postganglionic compound action potential, presynaptic nerve terminal spike and preganglionic nerve action potnetial were studied in rabbit and rat superior cervical gnaglia. Streptomycin had a dose-dependent, blocking effect on the postganglionic action potential. The drug was found t... | Ganglion blocking effects of streptomycin. The effects of streptomycin on the postganglionic compound action potential, presynaptic nerve terminal spike and preganglionic nerve action potnetial were studied in rabbit and rat superior cervical gnaglia. Streptomycin had a dose-dependent, blocking effect on the postgangli... | [
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PMID:27153 | An experimental non-invasive animal technique for measuring nasal airway resistance: I. Adrenergic and antihistaminic agents. | A non-invasive technically simple and sensitive method is described for the determination of nasal airway resistance (NAR). Aerosolized saline elicited a +/- 7% change in baseline NAR, duration 2 minutes, whereas aerosolized histamine increased NAR, duration is greater than 30 minutes. Aerosolized phenylephrine, norepi... | An experimental non-invasive animal technique for measuring nasal airway resistance: I. Adrenergic and antihistaminic agents. A non-invasive technically simple and sensitive method is described for the determination of nasal airway resistance (NAR). Aerosolized saline elicited a +/- 7% change in baseline NAR, duration ... | [
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PMID:27149 | [Nonspecific aorto-arteritis. Anatomo-pathological study of 18 cases]. | The present study comprises a pathological review of 18 necropsy cases with nonspecific aorto-arteritis (Takayasu's disease), autopsied at the Instituto Nacional de Cardiología of Mexico up to 1976. There were 11 females and 7 males with an average age at the time of death of 21.5 years. A comparison according to the d... | [Nonspecific aorto-arteritis. Anatomo-pathological study of 18 cases]. The present study comprises a pathological review of 18 necropsy cases with nonspecific aorto-arteritis (Takayasu's disease), autopsied at the Instituto Nacional de Cardiología of Mexico up to 1976. There were 11 females and 7 males with an average ... | [
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PMID:27154 | Age-dependence of renal tubular reabsorption of nitrofurantoin. | Nitrofurantoin is rapidly excreted in adult rats. However, in 5 to 15 days old rats the renal excretion of nitrofurantoin is diminshed by a high rate of reabsorption. Because nitrofurantoin has a pKa of 7.2 its tubular reabsorption is influenced by the urine pH but is independent of urine flow. About 50% of an administ... | Age-dependence of renal tubular reabsorption of nitrofurantoin. Nitrofurantoin is rapidly excreted in adult rats. However, in 5 to 15 days old rats the renal excretion of nitrofurantoin is diminshed by a high rate of reabsorption. Because nitrofurantoin has a pKa of 7.2 its tubular reabsorption is influenced by the uri... | [
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PMID:27155 | Hypersensitivity to salicylazosulfapyridine: renal and hepatic toxic reactions. | Salicylazosulfapyridine has been used for a number of years as therapy for ulcerative colitis. Reported toxicities are usually minor. This case report represents an acute allergic reaction to the drug. Characterized by fever, rash, eosinophilia, nephritis, and hepatitis. Resolution occurred with discontinuation of sali... | Hypersensitivity to salicylazosulfapyridine: renal and hepatic toxic reactions. Salicylazosulfapyridine has been used for a number of years as therapy for ulcerative colitis. Reported toxicities are usually minor. This case report represents an acute allergic reaction to the drug. Characterized by fever, rash, eosinoph... | [
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PMID:27156 | [The myocardiopathies of dermatomyositis and periarteritis nodosa]. | Myocardial involvement was indicated by isolated findings (especially on the ECG) without corresponding functional disorders in one third of cases of dermatomyositis. Rapidly fatal heart failure occurred rarely in this disease, and was noteworthy for a QS complex in the central precordial leads, and for the presence of... | [The myocardiopathies of dermatomyositis and periarteritis nodosa]. Myocardial involvement was indicated by isolated findings (especially on the ECG) without corresponding functional disorders in one third of cases of dermatomyositis. Rapidly fatal heart failure occurred rarely in this disease, and was noteworthy for a... | [
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PMID:27158 | Experiments on the preparations and testing of associated vaccine against foot and mouth disease and vesicular disease in swine. | Tests for associated immunization of swine against Foot and Mouth Disease (FMD) and Vesicular Disease (SVD) of swine were carried out. As a result of this investigation, it was established that the prepared and tested inactivated oil vaccine is harmless and immunogenic in sensitive animals. In investigating the course ... | Experiments on the preparations and testing of associated vaccine against foot and mouth disease and vesicular disease in swine. Tests for associated immunization of swine against Foot and Mouth Disease (FMD) and Vesicular Disease (SVD) of swine were carried out. As a result of this investigation, it was established th... | [
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PMID:27159 | [Properties and isozymes of acid and alkaline phosphatase in cattle testes and endometrium]. | The activity of acid phosphatase in the testicular parenchyma of cattle was found to be higher than that in the endometrium. The acid phosphatase of either tissue broke up p-nitrophenylphosphate at a rate twice as high as that reached for di-sodium phenylphosphate. Hydrolysis of phenolphthalein diphosphate was slower a... | [Properties and isozymes of acid and alkaline phosphatase in cattle testes and endometrium]. The activity of acid phosphatase in the testicular parenchyma of cattle was found to be higher than that in the endometrium. The acid phosphatase of either tissue broke up p-nitrophenylphosphate at a rate twice as high as that ... | [
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PMID:27160 | [Relationship between the limbic system and gonadal function. 3. Quantifiable prepuberal morphokinesis of the basolateral amygdaloid body and the ventral hippocampus formation]. | In juvenile female rats the neurons of the limbic system which are attached to the basolateral amygdaloid nucleus and to a circumscribed area of ventral hippocampal formation are characterised by markedly quantifiable morphokinesis between the 21st day of age and onset of the first oestrus. This morphokinesis will take... | [Relationship between the limbic system and gonadal function. 3. Quantifiable prepuberal morphokinesis of the basolateral amygdaloid body and the ventral hippocampus formation]. In juvenile female rats the neurons of the limbic system which are attached to the basolateral amygdaloid nucleus and to a circumscribed area ... | [
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PMID:27161 | [Blood acid-base status in fattening pigs in exhausting physical stress of high intensity]. | Reported in this paper are changes in the acid-base state and lactic concentration of blood and muscle samples taken from 28 pigs prior to, during, and after high-intensity exhausting stress applied at ambient temperatures between 17 degrees C and 21 degrees C and at 35 degrees C. Close correlations were found to exist... | [Blood acid-base status in fattening pigs in exhausting physical stress of high intensity]. Reported in this paper are changes in the acid-base state and lactic concentration of blood and muscle samples taken from 28 pigs prior to, during, and after high-intensity exhausting stress applied at ambient temperatures betwe... | [
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PMID:27162 | [Studies on diarrhea of young calves. 1. Quantitative analysis of the gastrointestinal flora in clinically healthy calves and in calves with diarrhea]. | Quantitative composition of gastro-intestinal-flora was determined in 23 clinically healthy calves and the course of germ spreading was followed up. In comparison with these healthy animals in 25 diarrhoea affected calves at the age of 4 to 17 days there could be observed signigicant differences only in few parts of th... | [Studies on diarrhea of young calves. 1. Quantitative analysis of the gastrointestinal flora in clinically healthy calves and in calves with diarrhea]. Quantitative composition of gastro-intestinal-flora was determined in 23 clinically healthy calves and the course of germ spreading was followed up. In comparison with ... | [
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PMID:27163 | Stabilization of human fibroblast interferon purified on concanavalin A-agarose. | Human fibroblast interferon, obtained by chromatography on concanavalin A-agarose, was stable for at least a month in 30--50 per cent ethylene glycol at 4 degrees, --20 degrees, and --70 degrees C. The succinct point of the present finding is that human fibroblast interferon may be stabilized by ethylene glycol alone w... | Stabilization of human fibroblast interferon purified on concanavalin A-agarose. Human fibroblast interferon, obtained by chromatography on concanavalin A-agarose, was stable for at least a month in 30--50 per cent ethylene glycol at 4 degrees, --20 degrees, and --70 degrees C. The succinct point of the present finding... | [
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PMID:27164 | Inhibition of thermogenic drinking by beta-adrenergic antagonists. | The thirst induced by transfer of rats from air at 5 degrees C to air at 25 degrees C (thermogenic drink) was inhibited by d,1-, but not d-propranolol (6 mg/kg body weight) administered 0.5 h prior to removal from cold. The thermogenic drink was not inhibited by a similar administration of the beta1-adrenergic antagoni... | Inhibition of thermogenic drinking by beta-adrenergic antagonists. The thirst induced by transfer of rats from air at 5 degrees C to air at 25 degrees C (thermogenic drink) was inhibited by d,1-, but not d-propranolol (6 mg/kg body weight) administered 0.5 h prior to removal from cold. The thermogenic drink was not inh... | [
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PMID:27167 | The effects of acridine orange on deoxyribonucleic acid in Escherichia coli. | 1. Acridine Orange inhibits growth of Escherichia coli K12 when incubated at pH 7.9, but not at pH 7.4.2. At a non-permissive temperature for DNA polymerase I, Acridine Orange inhibits growth of a temperature-sensitive strain and also increases the rate of elimination of the F'-Lac plasmid. 3. DNA isolated from cells t... | The effects of acridine orange on deoxyribonucleic acid in Escherichia coli. 1. Acridine Orange inhibits growth of Escherichia coli K12 when incubated at pH 7.9, but not at pH 7.4.2. At a non-permissive temperature for DNA polymerase I, Acridine Orange inhibits growth of a temperature-sensitive strain and also increase... | [
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PMID:27168 | Electron-paramagnetic-resonance studies on nitrate reductase from Escherichia coli K12. | Nitrate reductase was purified from anaerobically grown Escherichia coli K12 by a method based on the Triton X-100 extraction procedure of Clegg[(1976) Biochem. J.153, 533-541], but hydrophobic interaction chromatography was used in the final stage. E.p.r. spectra obtained from the enzyme under a variety of conditions ... | Electron-paramagnetic-resonance studies on nitrate reductase from Escherichia coli K12. Nitrate reductase was purified from anaerobically grown Escherichia coli K12 by a method based on the Triton X-100 extraction procedure of Clegg[(1976) Biochem. J.153, 533-541], but hydrophobic interaction chromatography was used in... | [
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PMID:27169 | Oxygen-binding characteristics of three extracellular haemoglobins of Artemia salina. | The oxygen-binding characteristics of the three extracellular haemoglobins of brine shrimp (Artemia salina) were studied in vitro by using highly purified preparations. Haemoglobin I is induced last in the development of brine shrimps when functional gills are formed. It has the lowest oxygen affinity (p(50) 5.34mmHg),... | Oxygen-binding characteristics of three extracellular haemoglobins of Artemia salina. The oxygen-binding characteristics of the three extracellular haemoglobins of brine shrimp (Artemia salina) were studied in vitro by using highly purified preparations. Haemoglobin I is induced last in the development of brine shrimps... | [
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PMID:27170 | Equilibrium binding of coenzymes and substrates to nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria. | 1. The stoicheiometries and affinities of ligand binding to isocitrate dehydrogenase were studied at pH 7.0, mainly by measuring changes in NADPH and protein fluorescence. 2. The affinity of the enzyme for NADPH is about 100-fold greater than it is for NADP+ in various buffer/salt solutions, and the affinities for both... | Equilibrium binding of coenzymes and substrates to nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria. 1. The stoicheiometries and affinities of ligand binding to isocitrate dehydrogenase were studied at pH 7.0, mainly by measuring changes in NADPH and protein flu... | [
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PMID:27171 | Transient kinetics of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria. | Pre-steady-state studies of the isocitrate dehydrogenase reaction show that the rate constant for the hydride-transfer step is above 990s-1, and that both subunits of the enzyme are simulataneously active. After the fast formation of NADPH in amounts equivalent to the enzyme subunit concentration, the rate of NADPH for... | Transient kinetics of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase from bovine heart mitochondria. Pre-steady-state studies of the isocitrate dehydrogenase reaction show that the rate constant for the hydride-transfer step is above 990s-1, and that both subunits of the enzyme are simulata... | [
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PMID:27172 | Purification and some properties of an alkaline proteinase from rat skeletal muscle. | 1. Rat skeletal muscle was homogenized in 0.05M-Tris/HCl, pH 8.5, containing 1M-KCl. Myofibrillar proteins were precipitated by addition of (NH4)2SO4 (33% saturation). 2. The alkaline proteolytic activity that was precipitated with the myofibrillar proteins was solubilized with trypsin (conjugated to Sepharose) and fur... | Purification and some properties of an alkaline proteinase from rat skeletal muscle. 1. Rat skeletal muscle was homogenized in 0.05M-Tris/HCl, pH 8.5, containing 1M-KCl. Myofibrillar proteins were precipitated by addition of (NH4)2SO4 (33% saturation). 2. The alkaline proteolytic activity that was precipitated with the... | [
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PMID:27198 | Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice. | A "feedback suppressor T cell" highly dependent on signals from Ly 1 T helper cells for activation is described. The signal from the Ly 1 cell binds to Fc-like receptors on macrophage membranes. The feedback suppressor cell expresses all three Ly antigens as well as the Qa 1 antigen on its surface, is very sensitive to... | Association of defective feedback suppressor T cell activity with autoimmunity in NZB mice. A "feedback suppressor T cell" highly dependent on signals from Ly 1 T helper cells for activation is described. The signal from the Ly 1 cell binds to Fc-like receptors on macrophage membranes. The feedback suppressor cell expr... | [
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PMID:27203 | Some clinical pharmacological studies with terfenadine, a new antihistamine drug. | 1 A double-blind cross-over trial between placebo, chlorpheniramine, and terfenadine, a new antihistamine drug, was performed in healthy male volunteers to determine and compare their CNS and autonomic effects. 2 Terfenadine and chlorpheniramine were administered orally in therapeutic doses. 3 In objective tests of cri... | Some clinical pharmacological studies with terfenadine, a new antihistamine drug. 1 A double-blind cross-over trial between placebo, chlorpheniramine, and terfenadine, a new antihistamine drug, was performed in healthy male volunteers to determine and compare their CNS and autonomic effects. 2 Terfenadine and chlorphen... | [
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PMID:27204 | Performance studies with antihistamines. | 1 Effect of four antihistamines, chlorpheniramine (4 mg), clemastine (1 mg), promethazine (10 mg) and terfenadine (60 mg), on visuo-motor coordination and on subjective assessments of performance and well-being were compared with placebo in six healthy females from 0.5--7.0 h after morning ingestion of each drug. The s... | Performance studies with antihistamines. 1 Effect of four antihistamines, chlorpheniramine (4 mg), clemastine (1 mg), promethazine (10 mg) and terfenadine (60 mg), on visuo-motor coordination and on subjective assessments of performance and well-being were compared with placebo in six healthy females from 0.5--7.0 h af... | [
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PMID:27205 | The acute effects of the administration of rimiterol aerosol in asthmatic children. | 1 Ten asthmatic children received on two separate occasions rimiterol (500 microgram) and orciprenaline (1.5 mg) as aerosols in a double-blind, crossover design trial. Respiratory parameters (FEV1, FVC and PEFR) and pulse rate were recorded for 60 min after each administration. 2 Rimiterol produced effective bronchodil... | The acute effects of the administration of rimiterol aerosol in asthmatic children. 1 Ten asthmatic children received on two separate occasions rimiterol (500 microgram) and orciprenaline (1.5 mg) as aerosols in a double-blind, crossover design trial. Respiratory parameters (FEV1, FVC and PEFR) and pulse rate were reco... | [
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PMID:27206 | Periarteritis nodosa and thrombotic thrombocytopenic purpura with serous retinal detachment in siblings. | Periarteritis nodosa and thrombotic thrombocytopenic purpura in siblings is reported. In both patients a localised serous retinal detachment and lesions of the retinal pigment epithelium had developed owing to choroidal vascular obstruction. These cases support the suggested possible relationship between the two condit... | Periarteritis nodosa and thrombotic thrombocytopenic purpura with serous retinal detachment in siblings. Periarteritis nodosa and thrombotic thrombocytopenic purpura in siblings is reported. In both patients a localised serous retinal detachment and lesions of the retinal pigment epithelium had developed owing to choro... | [
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PMID:27207 | Gastric secretion in suckling pigs and early-weaned pigs given a dry cow's-mild formula ad lib. | 1. Twelve gastric-cannulated litter-mate pigs were used to study secretion and proteolytic activity in the stomach of suckling and early-weaned pigs in relation to age and food intake. 2. Results demonstrate that from the first observation at day 8, piglets were able to secrete acid. pH and acid concentration did not c... | Gastric secretion in suckling pigs and early-weaned pigs given a dry cow's-mild formula ad lib. 1. Twelve gastric-cannulated litter-mate pigs were used to study secretion and proteolytic activity in the stomach of suckling and early-weaned pigs in relation to age and food intake. 2. Results demonstrate that from the fi... | [
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PMID:27210 | Studies on the microsomal mixed function oxidase system: redox properties of detergent-solubilized NADPH-cytochrome P-450 reductase. | Hepatic microsomal NADPH-cytochrome P-450 reductase was solubilized from rabbit liver microsomes in the presence of detergents and purified to homogeneity by column chromatography. The purified reductase had a molecular weight of 78 000 and contained 1 mol each of FAD and FMN per mol of enzyme. On reduction with NADPH ... | Studies on the microsomal mixed function oxidase system: redox properties of detergent-solubilized NADPH-cytochrome P-450 reductase. Hepatic microsomal NADPH-cytochrome P-450 reductase was solubilized from rabbit liver microsomes in the presence of detergents and purified to homogeneity by column chromatography. The pu... | [
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PMID:27211 | Reactions of reduced nicotinamide adenine dinucleotide in acid: studies by reversed-phase high-pressure liquid chromatography. | Reversed-phase high-pressure liquid chromatography was used to isolate acid breakdown products of reduced nicotinamide adenine dinucleotide (NADH) and products produced when NADH breakdown is catalyzed by glyceraldehyde-3-phosphate dehydrogenase (G-3-PD). Chromatographic and UV spectral data on these and related produc... | Reactions of reduced nicotinamide adenine dinucleotide in acid: studies by reversed-phase high-pressure liquid chromatography. Reversed-phase high-pressure liquid chromatography was used to isolate acid breakdown products of reduced nicotinamide adenine dinucleotide (NADH) and products produced when NADH breakdown is c... | [
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PMID:27212 | Affinity chromatography of H+-translocating adenosine triphosphatase isolated by chloroform extraction of Rhodospirillum rubrum chromatophores. Modification of binding affinity by divalent cations and activating anions. | 1. ATPase isolated from Rhodospirillum rubrum by chloroform extraction and purified by gel filtration or affinity chromatography shows three bands (alpha, beta and gamma) upon electrophoresis in sodium dodecyl sulphate. 2. Ca2+-ATPase activity of the preparation is inhibited by aurovertin and efrapeptin but not by olig... | Affinity chromatography of H+-translocating adenosine triphosphatase isolated by chloroform extraction of Rhodospirillum rubrum chromatophores. Modification of binding affinity by divalent cations and activating anions. 1. ATPase isolated from Rhodospirillum rubrum by chloroform extraction and purified by gel filtratio... | [
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PMID:27213 | Synergism of triggered luminescence by simultaneous treatment of pH transition and potassium addition in chloroplasts. | KCL-induced luminescence in relation to slow delayed light emission (greater than 3 s) and pH shift-triggered luminescence was studied in preilluminated chloroplasts. An activation pathway for KCl-induced luminescence similar to that for acidbase-triggered luminescence but different from that for delayed light emission... | Synergism of triggered luminescence by simultaneous treatment of pH transition and potassium addition in chloroplasts. KCL-induced luminescence in relation to slow delayed light emission (greater than 3 s) and pH shift-triggered luminescence was studied in preilluminated chloroplasts. An activation pathway for KCl-indu... | [
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PMID:27214 | Interaction of fluorinated ether anesthetics with artificial membranes. | Fluorine-19 nuclear magnetic resonance spectroscopy is applied to the study of the environment of dipalmitoyl phosphatidylcholine-bound fluorinated ether anesthetics (enflurane, fluoroxene and methoxyflurane) both below and above the lipid gel to liquid crystal phase transition temperature. Line widths and spin-lattice... | Interaction of fluorinated ether anesthetics with artificial membranes. Fluorine-19 nuclear magnetic resonance spectroscopy is applied to the study of the environment of dipalmitoyl phosphatidylcholine-bound fluorinated ether anesthetics (enflurane, fluoroxene and methoxyflurane) both below and above the lipid gel to l... | [
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PMID:27216 | Characterization of two poly(A) polymerases from cultured hamster fibroblasts. | The enzymatic and physiochemical properties of poly(A) polymerases IIA and IIB from cultured hamster fibroblasts were investigated. The enzymes show an absolute requirement for Mn2+ as the divalent ion. Although Mg2+ alone is inactive, maximum activity is observed in the presence of both Mn2+ and Mg2+. An optimal pH of... | Characterization of two poly(A) polymerases from cultured hamster fibroblasts. The enzymatic and physiochemical properties of poly(A) polymerases IIA and IIB from cultured hamster fibroblasts were investigated. The enzymes show an absolute requirement for Mn2+ as the divalent ion. Although Mg2+ alone is inactive, maxim... | [
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PMID:27217 | The phosphorylation of ribosomal proteins L14 and S3 in Krebs II ascites cells. | Krebs II ascites cells incubated in Earle's saline (lacking glucose and amino acids) contain ribosomes with proteins S6 and Lgamma phosphorylated, as do ascites cells grown in the peritonea of mice or hamster fibroblasts grown in Eagle's medium. When ascites cells were incubated in Eagle's medium (containing glucose an... | The phosphorylation of ribosomal proteins L14 and S3 in Krebs II ascites cells. Krebs II ascites cells incubated in Earle's saline (lacking glucose and amino acids) contain ribosomes with proteins S6 and Lgamma phosphorylated, as do ascites cells grown in the peritonea of mice or hamster fibroblasts grown in Eagle's me... | [
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PMID:27218 | Protein methylation in animal cells. I. Purification and properties of S-adenosyl-L-methionine:protein (arginine) N-methyltransferase from Krebs II ascites cells. | 1. A protein methylase which specifically transfers methyl groups from S-adenosyl-L-methionine to arginine residues of histones has been substantially purified from Krebs II ascites cells. The purified enzyme was obtained free of contamination by other protein methyl transferases specific for carboxyl and lysine residu... | Protein methylation in animal cells. I. Purification and properties of S-adenosyl-L-methionine:protein (arginine) N-methyltransferase from Krebs II ascites cells. 1. A protein methylase which specifically transfers methyl groups from S-adenosyl-L-methionine to arginine residues of histones has been substantially purifi... | [
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PMID:27219 | Poly(A) polymerases of rat liver nuclei. Purification and specificity. | Two poly(A) polymerases were isolated from rat liver nuclei and purified more than one thousand times by ion exchange chromatography on DEAE-Sephadex and phosphocellulose columns as well as affinity chromatography on a chromosomal RNA-Sepharose column. One of the two enzymes is bound to chromatin and uses as primer chr... | Poly(A) polymerases of rat liver nuclei. Purification and specificity. Two poly(A) polymerases were isolated from rat liver nuclei and purified more than one thousand times by ion exchange chromatography on DEAE-Sephadex and phosphocellulose columns as well as affinity chromatography on a chromosomal RNA-Sepharose colu... | [
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PMID:27220 | Inhibition of ribonuclease. Efficacy of sodium dodecyl sulfate, diethyl pyrocarbonate, protein ase K and heparin using a sensitive ribonuclease assay. | The effectiveness of several commonly used inhibitors of ribonuclease (RNAase) has been studied using the removal of radio-labelled leucine from leucyl-tRNA as a sensitive assay for RNAase activity. The inhibitors were tested under a variety of conditions, varying the temperature, the pH, and the source of RNAase. When... | Inhibition of ribonuclease. Efficacy of sodium dodecyl sulfate, diethyl pyrocarbonate, protein ase K and heparin using a sensitive ribonuclease assay. The effectiveness of several commonly used inhibitors of ribonuclease (RNAase) has been studied using the removal of radio-labelled leucine from leucyl-tRNA as a sensiti... | [
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PMID:27221 | Intramembraneous localization of rat liver microsomal hexose-6-phosphate dehydrogenase and membrane permeability to its substrates. | A method for purifying hexose-6-phosphate dehydrogenase (beta-D-glucose: NAD(P) -oxidoreductase, EC 1.1.1.47) from rat liver microsomes is described. The purified enzyme was shown to be homogeneous by sodium dodecyl sulfate (SDS)-polyacrylamide electrophoresis. It is shown that the enzyme is bound to the inner surface ... | Intramembraneous localization of rat liver microsomal hexose-6-phosphate dehydrogenase and membrane permeability to its substrates. A method for purifying hexose-6-phosphate dehydrogenase (beta-D-glucose: NAD(P) -oxidoreductase, EC 1.1.1.47) from rat liver microsomes is described. The purified enzyme was shown to be ho... | [
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PMID:27223 | Binding of m-nitrobenzeneboronic acid to the active site of subtilisin BPN. | m-Nitrobenzeneboronic acid as a possible transition-state analog for serine proteases was found to cause absorption spectral change from 250 nm 350 nm upon binding with subtilisin BPN' (EC 3.4.21.14) at pH 6.5. Similar difference spectral changes of m-nitrobenzeneboronic acid were also observed at alkaline pH or upon a... | Binding of m-nitrobenzeneboronic acid to the active site of subtilisin BPN. m-Nitrobenzeneboronic acid as a possible transition-state analog for serine proteases was found to cause absorption spectral change from 250 nm 350 nm upon binding with subtilisin BPN' (EC 3.4.21.14) at pH 6.5. Similar difference spectral chang... | [
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PMID:27224 | Excitation of indole-3-acetic acid (an auxin) in a linoleate-lipoxygenase system. | The weak luminescence that accompanies the linoleate-lipoxygenase reaction was greatly enhanced by the addition of indole analogues, and especially indole acetic acid. The main emitting species in the indole acetic acid-linoleate-lipoxygenase system was analysed spectrophotometrically in the visible region and ascribed... | Excitation of indole-3-acetic acid (an auxin) in a linoleate-lipoxygenase system. The weak luminescence that accompanies the linoleate-lipoxygenase reaction was greatly enhanced by the addition of indole analogues, and especially indole acetic acid. The main emitting species in the indole acetic acid-linoleate-lipoxyge... | [
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PMID:27225 | Lipid metabolism by The gall-bladder. II. The in vitro conversion of lysophosphatidylcholine to phosphatidylcholine. | Lysophosphatidylcholine acyltransferase, which catalyzes the acylation of lysophosphatidylcholine with fatty acid coenzyme A to form phosphatidylcholine, was assayed in gall-bladder mucosa. In guinea pig gall-bladder the activity parallels that of the microsomal enzyme, glucose-6-phosphatase with 3--4-fold enrichment o... | Lipid metabolism by The gall-bladder. II. The in vitro conversion of lysophosphatidylcholine to phosphatidylcholine. Lysophosphatidylcholine acyltransferase, which catalyzes the acylation of lysophosphatidylcholine with fatty acid coenzyme A to form phosphatidylcholine, was assayed in gall-bladder mucosa. In guinea pig... | [
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PMID:27226 | Sites of direct and indirect halogenation of albumin. | The sites of radiohalogenation in proteins vary with the labeling method and the pH of the labeling reaciton. We have directly halogenated albumin with carrier-free radioiodide by three methods (pH range 2.2--9.3), and with carrier-free radiobromide by the chloroperoxidase method (pH range 2.2--4.6). Albumin was also i... | Sites of direct and indirect halogenation of albumin. The sites of radiohalogenation in proteins vary with the labeling method and the pH of the labeling reaciton. We have directly halogenated albumin with carrier-free radioiodide by three methods (pH range 2.2--9.3), and with carrier-free radiobromide by the chloroper... | [
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PMID:27227 | Characteristics and conversion of high molecular weight forms of renin in plasma and their incomplete activation by the current acid treatment. | Two distinctly different high molecular weight forms of renin are present in mouse plasma in addition to the well-recognized active 40 000 dalton form. The biggest form has a molecular weight of about 800 000, and is stable in 4 M urea, but can be converted to the active 40 000 dalton form, by storage, exposure to acid... | Characteristics and conversion of high molecular weight forms of renin in plasma and their incomplete activation by the current acid treatment. Two distinctly different high molecular weight forms of renin are present in mouse plasma in addition to the well-recognized active 40 000 dalton form. The biggest form has a m... | [
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PMID:27228 | Effect of pH on bovine liver catalase as determined by electron paramagnetic resonance. | Two major rhombic high-spin ferric heme signals are observed during the pH titration of bovine liver catalase. The less rhombic signal if dominant above pH 6.0 and the more rhombic signal below pH 6.0. Ethanol in high concentration enhances the relative intensity of the less rhombic signal. These data demonstrate the s... | Effect of pH on bovine liver catalase as determined by electron paramagnetic resonance. Two major rhombic high-spin ferric heme signals are observed during the pH titration of bovine liver catalase. The less rhombic signal if dominant above pH 6.0 and the more rhombic signal below pH 6.0. Ethanol in high concentration ... | [
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PMID:27229 | Studies on erythrocruorin. VII. Reconstitution of earthworm erythrocruorin from the apoprotein. | Apoerythrocruorin prepared from the giant respiratory hemoprotein of the earthworm (60 S, Mr = 3 X 10(-6)) is an electrophoretically homogeneous molecule which sediments as a single peak of low molecular weight (3.5 S) and has a lower alpha-helical content (approx. 30%) than the native protein. Titration of globin with... | Studies on erythrocruorin. VII. Reconstitution of earthworm erythrocruorin from the apoprotein. Apoerythrocruorin prepared from the giant respiratory hemoprotein of the earthworm (60 S, Mr = 3 X 10(-6)) is an electrophoretically homogeneous molecule which sediments as a single peak of low molecular weight (3.5 S) and h... | [
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PMID:27230 | Oxygen equilibrium analyses of isolated hemoglobins A2, Lepore-Washington and P-nilotic. | Oxygen equilibrium studies have been carried out on hemoglobins A2 (alpha2delta2), Lepore-Washington (alpha2(deltabeta)2) and P-Nilotic (alpha2(beta2delta)2) using the beta chain containing hemoglobins A and S as controls. This investigation was initiated mainly because of controversial data that have been published on... | Oxygen equilibrium analyses of isolated hemoglobins A2, Lepore-Washington and P-nilotic. Oxygen equilibrium studies have been carried out on hemoglobins A2 (alpha2delta2), Lepore-Washington (alpha2(deltabeta)2) and P-Nilotic (alpha2(beta2delta)2) using the beta chain containing hemoglobins A and S as controls. This inv... | [
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PMID:27231 | The cleavage and adsorption of parathyroid hormone at high dilution: implications for receptor binding studies. | Like other polypeptide hormones, purified intact parathyroid hormone (1-84)parathyroid hormone is notoriously unstable and is subject to large adsorptive losses in routine laboratory manipulation. The present studies were undertaken with 125I-labeled hormone to quantitate the problem and to develop preventative measure... | The cleavage and adsorption of parathyroid hormone at high dilution: implications for receptor binding studies. Like other polypeptide hormones, purified intact parathyroid hormone (1-84)parathyroid hormone is notoriously unstable and is subject to large adsorptive losses in routine laboratory manipulation. The present... | [
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PMID:27232 | An evaluation of respiration chain-associated functions during initiation of germination of Bacillus megaterium spores. | In Bacillus megaterium QM B1551, spore germination could be initiated by glucose in the absence of detectable oxygen consumption, ATP synthesis or a pH decrease in the external media, suggesting that none of those reactions were mandatory. In addition, initiation of germination was insensitive to a variety of inhibitor... | An evaluation of respiration chain-associated functions during initiation of germination of Bacillus megaterium spores. In Bacillus megaterium QM B1551, spore germination could be initiated by glucose in the absence of detectable oxygen consumption, ATP synthesis or a pH decrease in the external media, suggesting that ... | [
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PMID:27233 | Mediated transport and metabolism of lactate in rat aorta. | 1. Under appropriate conditions L- and D-lactate enter the cells of rat aorta and are metabolized. Oxidation of lactate to CO2 occurs under aerobic conditions. 2. L- and D-lactate are taken up into the cells when oxygen, glucose, or both oxygen and glucose are present in the incubation medium. Both L- and D-lactate are... | Mediated transport and metabolism of lactate in rat aorta. 1. Under appropriate conditions L- and D-lactate enter the cells of rat aorta and are metabolized. Oxidation of lactate to CO2 occurs under aerobic conditions. 2. L- and D-lactate are taken up into the cells when oxygen, glucose, or both oxygen and glucose are ... | [
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PMID:27234 | Changes in collagen cross-linking and lysyl oxidase by estrogen. | Dermal collagen solubility and lysyl oxidase activity of bones were measured in DDD mice of advancing age. Insoluble fractions of the dermal collagen increased more rapidly in females than in males after 5 weeks of age. Activity of the lysyl oxidase extracted from bones was higher in females than in males after 4 weeks... | Changes in collagen cross-linking and lysyl oxidase by estrogen. Dermal collagen solubility and lysyl oxidase activity of bones were measured in DDD mice of advancing age. Insoluble fractions of the dermal collagen increased more rapidly in females than in males after 5 weeks of age. Activity of the lysyl oxidase extra... | [
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PMID:27235 | Effects of catecholamines and glucagon on glycogen metabolism in human polymorphonuclear leukocytes. | Addition of 10 micron of the alpha-adrenergic agonist phenylephrine to polymorphonuclear leukocytes suspended in glucose-free Krebs-Ringer bicarbonate buffer (pH 6.7) activated phosphorylase, inactivated glycogen synthase R maximally within 30 s, and resulted in glycogen breakdown. Phenylephrine increased 45Ca efflux r... | Effects of catecholamines and glucagon on glycogen metabolism in human polymorphonuclear leukocytes. Addition of 10 micron of the alpha-adrenergic agonist phenylephrine to polymorphonuclear leukocytes suspended in glucose-free Krebs-Ringer bicarbonate buffer (pH 6.7) activated phosphorylase, inactivated glycogen syntha... | [
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PMID:27236 | Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution. | Turkey erythrocytes possess insulin receptors with binding properties very similar to those of mammalian insulin receptors. In the present study, the insulin receptor of the avian erythrocyte has been solubilized in Triton X-100, extensively characterized and partially purified, and its properties compared to those of ... | Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution. Turkey erythrocytes possess insulin receptors with binding properties very similar to those of mammalian insulin receptors. In the present study, the insulin receptor of the... | [
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PMID:27241 | Properties of partially purified bovine brain dopamine beta-hydroxylase. | Dopamine beta-hydroxylase has been partially purified from bovine brain. A 140-fold purification factor was achieved using solubilization with Triton X-100, ammonium sulphate fractionation between 20-50 per cent saturation, affinity chromatography on concanavalin A-Sepharose 4 B and then filtration through Sephadex G20... | Properties of partially purified bovine brain dopamine beta-hydroxylase. Dopamine beta-hydroxylase has been partially purified from bovine brain. A 140-fold purification factor was achieved using solubilization with Triton X-100, ammonium sulphate fractionation between 20-50 per cent saturation, affinity chromatography... | [
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PMID:27238 | [Effect of pH on the permeability and mechanical properties of intercellular contacts in the small intestinal epithelium]. | It is shown that acid site population controlling ion permeation through cell contacts is localized in the region of tight junction. The isoelectric point of cell surface in the region to tight junction changed from mean pH = 2.37 +/- 0.1 for duodenum to pH =2.80 +/- +/- 0.1 for ileum. The maximum of cell adhesion in ... | [Effect of pH on the permeability and mechanical properties of intercellular contacts in the small intestinal epithelium]. It is shown that acid site population controlling ion permeation through cell contacts is localized in the region of tight junction. The isoelectric point of cell surface in the region to tight jun... | [
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PMID:27242 | New trends in cryoenzymology: I.-Supercooled aqueous solutions. | A water in oil emulsion technique is proposed to investigate enzyme catalyzed reactions at sub-zero temperatures in the supercooled liquid state to avoid some reversible effects of the usual cosolvents on kinetics. Some results are listed: potentialities and technical problems of the procedure are discussed. | New trends in cryoenzymology: I.-Supercooled aqueous solutions. A water in oil emulsion technique is proposed to investigate enzyme catalyzed reactions at sub-zero temperatures in the supercooled liquid state to avoid some reversible effects of the usual cosolvents on kinetics. Some results are listed: potentialities a... | [
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PMID:27239 | [Phosphorylation in acid shocked chloroplasts]. | ADP phosphorylation up to 2.5 nmol per mg of chlorphyll has been found in chloroplasts from Vicia faba plants when the suspension was sharply acidified from pH 8 to pH 1.6 with excess of HC1/KC1 solution. This fact appears to be due to confromation relaxation of the coupling factor under acid-induced denaturation. Heat... | [Phosphorylation in acid shocked chloroplasts]. ADP phosphorylation up to 2.5 nmol per mg of chlorphyll has been found in chloroplasts from Vicia faba plants when the suspension was sharply acidified from pH 8 to pH 1.6 with excess of HC1/KC1 solution. This fact appears to be due to confromation relaxation of the coupl... | [
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PMID:27244 | Capacity for biosynthesis of prostaglandin-related compounds: distribution and properties of the rate-limiting enzyme in hydrocorals, gorgoniants, and other coelenterates of the Caribbean and Pacific. | A convenient and reliable assay is described for PGEP synthetase, the rate-limiting enzyme determining the total capacity for biosynthesis of prostaglandin-related compounds. Results of such assays, performed withe fresh specimens under both field and laboratory conditions, newly identify several marine coelenterate sp... | Capacity for biosynthesis of prostaglandin-related compounds: distribution and properties of the rate-limiting enzyme in hydrocorals, gorgoniants, and other coelenterates of the Caribbean and Pacific. A convenient and reliable assay is described for PGEP synthetase, the rate-limiting enzyme determining the total capaci... | [
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PMID:27245 | [Kinetics and mechanism of nucleophilic effect on the oxidation of o-dianisidine catalyzed by horseradish peroxidase]. | The effects of benzimidazole and 4-nitroimidazole on the reaction of o-dianisidine peroxidase oxidation within the pH range of 3.7--9.0 were studied. Both substituted imidazoles activate the reaction at less than 0.6. In the presence of 4-nitroimidazole the activation is non-competitive, whereas in the presence of benz... | [Kinetics and mechanism of nucleophilic effect on the oxidation of o-dianisidine catalyzed by horseradish peroxidase]. The effects of benzimidazole and 4-nitroimidazole on the reaction of o-dianisidine peroxidase oxidation within the pH range of 3.7--9.0 were studied. Both substituted imidazoles activate the reaction a... | [
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PMID:27246 | [Properties of cyclic nucleotide phosphodiesterase from lingual taste papillae]. | Phosphodiesterase activity is estimated in extracts and partially purified preparations from functionally different parts of bovine tongue. The enzyme activity varied from 4.0 to 10.4 nmole/mg of protein/min. Properties of phosphodiesterase from circumvallate papillae are studied, the pH optimum being 8.0--8.5, Km for ... | [Properties of cyclic nucleotide phosphodiesterase from lingual taste papillae]. Phosphodiesterase activity is estimated in extracts and partially purified preparations from functionally different parts of bovine tongue. The enzyme activity varied from 4.0 to 10.4 nmole/mg of protein/min. Properties of phosphodiesteras... | [
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PMID:27247 | [Coenzyme-induced slow transitions of NADP-sorbitol dehydrogenase from Gluconobacter oxydans]. | The kinetic properties of NADP-dependent sorbitol dehydrogenase from G. oxydans cell extract were studied at pH 8.8 and 9.3 in the direction of D-sorbitol oxydation. It was shown that the shape of the kinetic curves of NADPH accumulation in time is characterised by initial burst whose magnitude depends on the concentra... | [Coenzyme-induced slow transitions of NADP-sorbitol dehydrogenase from Gluconobacter oxydans]. The kinetic properties of NADP-dependent sorbitol dehydrogenase from G. oxydans cell extract were studied at pH 8.8 and 9.3 in the direction of D-sorbitol oxydation. It was shown that the shape of the kinetic curves of NADPH ... | [
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PMID:27248 | [Presence of SH-groups and histidine in the active site of Chlorella glutamine synthetase]. | The presence of two cysteine residues per each six monomers comprising the oligomer of Chlorella glutamine synthetase (E.C.6.3.1.2) is demonstrated using homogenous enzyme preparation. p-Chloromercuribenzoate (p-CMB) is found to inhibit glutamine synthetase activity, the degree of inhibition depending on the inhibitor ... | [Presence of SH-groups and histidine in the active site of Chlorella glutamine synthetase]. The presence of two cysteine residues per each six monomers comprising the oligomer of Chlorella glutamine synthetase (E.C.6.3.1.2) is demonstrated using homogenous enzyme preparation. p-Chloromercuribenzoate (p-CMB) is found to... | [
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PMID:27249 | [Isolation, purification and characterization of regulatory properties of adenylate cyclase from rabbit heart]. | Rabbit heart membranes possessing the adenylate cyclase activity were isolated and purified by extraction with high ionic strength solutions and centrifugation in the sucrose density gradient. It was shown that the membranes are characterized by a high percentage of cholesterol (molar ratio cholesterol/phospholipids is... | [Isolation, purification and characterization of regulatory properties of adenylate cyclase from rabbit heart]. Rabbit heart membranes possessing the adenylate cyclase activity were isolated and purified by extraction with high ionic strength solutions and centrifugation in the sucrose density gradient. It was shown th... | [
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PMID:27250 | [Properties of DNA-methylase reaction in isolated nuclei of normal and regenerating rat liver]. | Evidence from comparative determination of DNA radioactivity methylation degree of acidic extraction and chlorophormic deproteination of the samples suggest that the former technique is a more efficient one. The properties of the DNA-methylase reaction in isolated rat liver nuclei were studied. The DNA-methylase activi... | [Properties of DNA-methylase reaction in isolated nuclei of normal and regenerating rat liver]. Evidence from comparative determination of DNA radioactivity methylation degree of acidic extraction and chlorophormic deproteination of the samples suggest that the former technique is a more efficient one. The properties o... | [
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PMID:27251 | [Effect of cortisol on the content of mRNA coding inducible tyrosine aminotransferase isoenzyme in rat liver]. | In vitro estimation of synthesis of inducible tyrosine aminotransferase isoenzyme, directed by poly-A-containing RNA from liver of intact and corticol treated rats, is carried out. Total poly-A-containing RNA from liver polyribosomes of intact and induced rats was translated in cell-free system from wheat germs. Two an... | [Effect of cortisol on the content of mRNA coding inducible tyrosine aminotransferase isoenzyme in rat liver]. In vitro estimation of synthesis of inducible tyrosine aminotransferase isoenzyme, directed by poly-A-containing RNA from liver of intact and corticol treated rats, is carried out. Total poly-A-containing RNA ... | [
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PMID:27252 | Evaluating clustering methods for psychiatric diagnosis. | This report represents an empirical evaluation of the major clustering approaches on psychiatric diagnostic data. Experienced psychiatrists, using 17 psychopathological variables, developed 88 archetypal psychiatric patients to represent four diagnostic categories (manic-depressive depressed, manic-depressive manic, si... | Evaluating clustering methods for psychiatric diagnosis. This report represents an empirical evaluation of the major clustering approaches on psychiatric diagnostic data. Experienced psychiatrists, using 17 psychopathological variables, developed 88 archetypal psychiatric patients to represent four diagnostic categorie... | [
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0.0774851068854332,
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0.02665848098695278,
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