id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:27456 | Heat-stable enterotoxin from Escherichia coli: factors involved in growth and toxin production. | Six enterotoxigenic strains of Escherichia coli produced variable levels of heat-stable enterotoxin (ST) when grown under pH control at 8.5 in a simple synthetic medium containing neither amino acids nor vitamins. Bacterial growth and ST production were at levels as high as or higher than those observed in complex medi... | Heat-stable enterotoxin from Escherichia coli: factors involved in growth and toxin production. Six enterotoxigenic strains of Escherichia coli produced variable levels of heat-stable enterotoxin (ST) when grown under pH control at 8.5 in a simple synthetic medium containing neither amino acids nor vitamins. Bacterial ... | [
-0.04805966466665268,
-0.009068337269127369,
0.010242387652397156,
0.009485765360295773,
0.04075329005718231,
-0.03519430384039879,
0.011888866312801838,
0.012734148651361465,
-0.03861582651734352,
0.01817302219569683,
0.008144877851009369,
-0.07382486760616302,
0.06361069530248642,
0.0430... |
PMID:27457 | Allosteric transformation of reduced nicotinamide adenine dinucleotide (phosphate) oxidase induced by phagocytosis in human polymorphonuclear leukocytes. | We used sensitive isotopic and fluorometric assay procedures to investigate reduced nicotinamide adenine dinucleotide (phosphate) [NAD(P)H]oxidation in a particulate fraction derived from normal and chronic granulomatous disease leukocytes. Granules isolated from normal resting cells showed allosteric kinetics with reg... | Allosteric transformation of reduced nicotinamide adenine dinucleotide (phosphate) oxidase induced by phagocytosis in human polymorphonuclear leukocytes. We used sensitive isotopic and fluorometric assay procedures to investigate reduced nicotinamide adenine dinucleotide (phosphate) [NAD(P)H]oxidation in a particulate ... | [
-0.08185557276010513,
0.031805723905563354,
-0.04930396378040314,
-0.03569738566875458,
0.012130807153880596,
0.015141081996262074,
0.049063991755247116,
0.028245823457837105,
-0.046210356056690216,
-0.0058896481059491634,
0.009147762320935726,
-0.06458605825901031,
0.024218963459134102,
0... |
PMID:27458 | Cell envelope of Neisseria gonorrhoeae: phospholipase activity and its relationship to autolysis. | The relationship between conditions which permit or inhibit cell lysis and those which promote phospholipid hydrolysis in Neisseria gonorrhoeae was investigated. Suspension of exponential-phase gonococci in buffer in the absence of divalent cations resulted in autolysis but not in phosphlipid hydrolysis. The addition o... | Cell envelope of Neisseria gonorrhoeae: phospholipase activity and its relationship to autolysis. The relationship between conditions which permit or inhibit cell lysis and those which promote phospholipid hydrolysis in Neisseria gonorrhoeae was investigated. Suspension of exponential-phase gonococci in buffer in the a... | [
-0.01284002885222435,
0.006326615344733,
0.014486459083855152,
0.01140008307993412,
-0.046614497900009155,
-0.05857570096850395,
0.05456778407096863,
0.06459193676710129,
-0.06553305685520172,
-0.009765412658452988,
0.02458266355097294,
-0.06994841247797012,
0.033504415303468704,
0.0210117... |
PMID:27459 | Immunochemical studies on a Mycoplasma pneumoniae polysaccharide fraction: cross-reactions with type 23 and 32 antipneumococcal rabbit sera. | Lipid-free polysaccharide fraction 2 extracted from Mycoplasma pneumoniae strain FH by Prescott et al. (J. Bacteriol. 91:2117-2115, 1966) was examined for its ability to cross-precipitate antibody from type-specific rabbit antipneumococcal sera types 1 to 34 inclusive. Cross-precipitation in type-specific pneumococcal ... | Immunochemical studies on a Mycoplasma pneumoniae polysaccharide fraction: cross-reactions with type 23 and 32 antipneumococcal rabbit sera. Lipid-free polysaccharide fraction 2 extracted from Mycoplasma pneumoniae strain FH by Prescott et al. (J. Bacteriol. 91:2117-2115, 1966) was examined for its ability to cross-pre... | [
-0.08060689270496368,
-0.021242758259177208,
-0.0312906913459301,
0.016362521797418594,
0.06139305233955383,
-0.03692138195037842,
0.018305258825421333,
-0.00460071163251996,
-0.056278180330991745,
0.028752164915204048,
0.0233920831233263,
-0.06697569042444229,
-0.009797659702599049,
-0.03... |
PMID:27460 | Activation of alveolar macrophages exposed to lavage-procured immunoglobulin G obtained from normal rabbit lungs. | Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings o... | Activation of alveolar macrophages exposed to lavage-procured immunoglobulin G obtained from normal rabbit lungs. Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass... | [
-0.055808909237384796,
0.002694368828088045,
-0.0009073110995814204,
-0.018731800839304924,
-0.017847873270511627,
-0.010772024281322956,
0.059699833393096924,
0.06134564429521561,
-0.07139305025339127,
0.016924649477005005,
-0.057626280933618546,
-0.06296773254871368,
0.002697031944990158,
... |
PMID:27461 | Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans. | We have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant. Thus vaccine was administered by the aerosol route to working men free of any important disease, especially of respiratory disease. A total of 104 men working for the C... | Immuno-stimulation by a ribosomal vaccine associated with a bacterial cell wall adjuvant in humans. We have studied a new vaccine of ribosomal nature associated with glycoprotein cell walls from Klebsiella pneumoniae which served as an immunoadjuvant. Thus vaccine was administered by the aerosol route to working men fr... | [
-0.04692619666457176,
-0.0009062856552191079,
0.010038798674941063,
-0.012465564534068108,
0.06358014047145844,
-0.024647969752550125,
0.036434948444366455,
0.03332582861185074,
-0.056659962981939316,
-0.04449202120304108,
-0.007552345283329487,
-0.09592670947313309,
0.03084929846227169,
-... |
PMID:27463 | Comparative investigation of the respiratory and cardiovascular effect of mepindolol, propranolol and pindolol in asthmatic patients. | In a controlled double-blind crossover trial of 5 mg mepindolol versus 80 mg propranolol, 15 mg pindolol or placebo given as single oral doses in 16 asthmatic patients, respiratory function and cardiovascular parameters were measured simultaneously. The doses chosen of the 3 active drugs were almost equipotent as shown... | Comparative investigation of the respiratory and cardiovascular effect of mepindolol, propranolol and pindolol in asthmatic patients. In a controlled double-blind crossover trial of 5 mg mepindolol versus 80 mg propranolol, 15 mg pindolol or placebo given as single oral doses in 16 asthmatic patients, respiratory funct... | [
-0.07154126465320587,
-0.01145240105688572,
0.0075777205638587475,
0.01586245931684971,
-0.016505591571331024,
-0.02385954186320305,
0.04973829165101051,
0.03938114270567894,
-0.03741741552948952,
-0.049793049693107605,
-0.0007203975692391396,
-0.004607182927429676,
0.02062034420669079,
0.... |
PMID:27464 | Assessment of beta-blocking activity of trimepranol in man. | The beta-blocking potency and the duration of action of trimepranol were measured in healthy volunteers using isoprenaline antagonism and reduction in exercise tachycardia. Based on isoprenaline antagonism, trimepranol was four times as potent as propranolol on a weight basis. The degree of beta blockade increased line... | Assessment of beta-blocking activity of trimepranol in man. The beta-blocking potency and the duration of action of trimepranol were measured in healthy volunteers using isoprenaline antagonism and reduction in exercise tachycardia. Based on isoprenaline antagonism, trimepranol was four times as potent as propranolol o... | [
-0.05568091198801994,
-0.019293230026960373,
0.022657403722405434,
-0.020772136747837067,
0.003438765648752451,
0.047166772186756134,
0.016918089240789413,
0.02417660504579544,
-0.035105083137750626,
-0.04529154300689697,
-0.010582257062196732,
-0.03305603936314583,
-0.023828228935599327,
... |
PMID:27465 | Diazepam and halazepam in anxiety: some prognostic indicators. | A multiple step-search regression procedure was applied to data obtained with 37 diazepam and 42 halazepam treated anxious outpatients. Good treatment outcome was predicted for those patients who reported a more adequate family adjustment, the presence of precipitating stress, and who either had no prior psychotropic d... | Diazepam and halazepam in anxiety: some prognostic indicators. A multiple step-search regression procedure was applied to data obtained with 37 diazepam and 42 halazepam treated anxious outpatients. Good treatment outcome was predicted for those patients who reported a more adequate family adjustment, the presence of p... | [
-0.022359566763043404,
0.038684405386447906,
0.03614212945103645,
0.04173470661044121,
0.01740070804953575,
0.026200544089078903,
0.07617579400539398,
0.018596384674310684,
-0.027271246537566185,
-0.07285311073064804,
0.0383259542286396,
0.0073889270424842834,
-0.03492316976189613,
-0.0163... |
PMID:27466 | Drug interactions in psychiatry. | Since maintenance therapy with neuroleptics, lithium and tricyclic antidepressants may have to continue over extended periods of time, drug interactions between these psychotherapeutic agents and non-psychotropic treatments have become of practical clinical significance. In this paper some of the more common or importa... | Drug interactions in psychiatry. Since maintenance therapy with neuroleptics, lithium and tricyclic antidepressants may have to continue over extended periods of time, drug interactions between these psychotherapeutic agents and non-psychotropic treatments have become of practical clinical significance. In this paper s... | [
-0.05505634844303131,
0.06647669523954391,
-0.01838771067559719,
-0.03952097147703171,
0.019765621051192284,
-0.016735224053263664,
0.07805801182985306,
-0.024021582677960396,
-0.022417407482862473,
-0.11294609308242798,
0.04100821912288666,
0.02515474148094654,
0.03720422834157944,
0.0282... |
PMID:27468 | Localization of beta receptors in the anterior segment of the rat eye by a fluorescent analogue of propranolol. | A fluorescent analogue of propranolol, 9-AAP, was injected intravenously in order to detect beta-adrenergic receptors in the anterior segment of the albino rat eye. Specific 9-AAP fluorescence was noted along cell membranes of the ciliary epithelium and to lesser extent in the walls of blood vessels in the ciliary proc... | Localization of beta receptors in the anterior segment of the rat eye by a fluorescent analogue of propranolol. A fluorescent analogue of propranolol, 9-AAP, was injected intravenously in order to detect beta-adrenergic receptors in the anterior segment of the albino rat eye. Specific 9-AAP fluorescence was noted along... | [
-0.028622513636946678,
-0.05402854084968567,
-0.025566237047314644,
-0.0033789295703172684,
-0.023754378780722618,
0.025669122114777565,
0.10014069825410843,
0.020253203809261322,
-0.041243311017751694,
-0.02284032665193081,
0.006926015485078096,
-0.03589228540658951,
-0.0320136733353138,
... |
PMID:27469 | Light-evoked release of endogenous glycine into the perfused vitreous of the intact rat eye. | Glycine, a putative neurotransmitter, is released into the perfused vitreous of anesthetized pigmented rats when the eye is stimulated by intermittent flashes of bright light. Other amino acids do not show stimulated release. This result provides further evidence for the role of glycine as a neural transmitter in the r... | Light-evoked release of endogenous glycine into the perfused vitreous of the intact rat eye. Glycine, a putative neurotransmitter, is released into the perfused vitreous of anesthetized pigmented rats when the eye is stimulated by intermittent flashes of bright light. Other amino acids do not show stimulated release. T... | [
0.019175207242369652,
-0.002565931063145399,
-0.022825388237833977,
-0.010098973289132118,
-0.026492254808545113,
0.03485638648271561,
0.06409429758787155,
0.0013412636471912265,
0.006632570177316666,
0.0017384747043251991,
0.0016409497475251555,
-0.05284474417567253,
-0.020232591778039932,
... |
PMID:27471 | Proximal renal tubular acidosis in metachromatic leukodystrophy. | A 2-year-old girl affected with the late infantile form of metachromatic leukodystrophy had a persistent and moderate metabolic acidosis. Renal functional studies demonstrated the presence of decreased tubular reabsorption of sodium, bicarbonate and some amino acids. Other tubular functions, including distal urinary ac... | Proximal renal tubular acidosis in metachromatic leukodystrophy. A 2-year-old girl affected with the late infantile form of metachromatic leukodystrophy had a persistent and moderate metabolic acidosis. Renal functional studies demonstrated the presence of decreased tubular reabsorption of sodium, bicarbonate and some ... | [
-0.05342962220311165,
-0.10607022792100906,
0.011930502951145172,
0.03713592514395714,
-0.02748769149184227,
-0.019262664020061493,
0.09844011813402176,
0.03421946242451668,
-0.03809890151023865,
0.010524248704314232,
0.06302540004253387,
-0.08097851276397705,
0.055740419775247574,
0.07585... |
PMID:27484 | In vitro evaluations of monopolar intravascular oxygen sensors. | Intravascular PO2 electrodes of a commercially available design were tested in vitro to establish their characteristics and to further elucidate on their clinical usability. In addition, four different cathode-anode combinations, utilizing the same geometrical design, were evaluated to establich the best combination. A... | In vitro evaluations of monopolar intravascular oxygen sensors. Intravascular PO2 electrodes of a commercially available design were tested in vitro to establish their characteristics and to further elucidate on their clinical usability. In addition, four different cathode-anode combinations, utilizing the same geometr... | [
-0.03280136361718178,
-0.00752865569666028,
-0.005101604852825403,
0.02464180812239647,
0.011678495444357395,
-0.01468071062117815,
0.0573321133852005,
0.0531216636300087,
-0.019732167944312096,
-0.011603576131165028,
-0.01735694706439972,
-0.07295499742031097,
0.011147204786539078,
0.0499... |
PMID:27485 | Regulation of intracellular pH in lungs and other tissues during hypercapnia. | Using a 14C-labeled DMO, 36Cl and 3H method, we have determined the in vivo buffering capacity of lung, kidney, heart, skeletal muscle, and extracellular fluid (ECF) of guinea pigs during hypercapnia (FICO2 = 0.15). After 1 days' exposureto 15% CO2, both the relative CO2 buffer values (delta HCO3/deltapH) and the "%pH ... | Regulation of intracellular pH in lungs and other tissues during hypercapnia. Using a 14C-labeled DMO, 36Cl and 3H method, we have determined the in vivo buffering capacity of lung, kidney, heart, skeletal muscle, and extracellular fluid (ECF) of guinea pigs during hypercapnia (FICO2 = 0.15). After 1 days' exposureto 1... | [
-0.03497869521379471,
-0.024495074525475502,
0.01859743893146515,
0.034588977694511414,
0.04108680784702301,
-0.027343429625034332,
0.08969630300998688,
0.019394313916563988,
-0.03163275495171547,
0.01295293215662241,
0.000060473521443782374,
-0.121810182929039,
-0.023195302113890648,
0.04... |
PMID:27486 | Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin. | Studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (DPG), the intracellular red cell and extracellular pH, and the switchover to adult hemoglobin synthesis in regulating the position of the fetal red cell oxygen-affinity curve in utero. Adult hemoglobin first app... | Red cell oxygen affinity in fetal sheep: role of 2,3-DPG and adult hemoglobin. Studies were carried out during fetal life in sheep to determine the relationship of 2,3-diphosphoglycerate (DPG), the intracellular red cell and extracellular pH, and the switchover to adult hemoglobin synthesis in regulating the position o... | [
-0.06212750822305679,
0.05474570021033287,
-0.014991081319749355,
0.016992591321468353,
0.03433593735098839,
0.014043906703591347,
0.07239336520433426,
0.04345802590250969,
-0.04084248095750809,
0.010128553956747055,
0.04483868181705475,
-0.06346675008535385,
-0.009295878000557423,
0.00263... |
PMID:27489 | Management an experimental approach. | An experimental teaching procedure was devised and tested for integrating the nursing process, nursing care plans, the research process and management principals. The integration defined as the problem oriented process (POP) was tested with 16 students over two semesters. The results indicated that the POP was a succes... | Management an experimental approach. An experimental teaching procedure was devised and tested for integrating the nursing process, nursing care plans, the research process and management principals. The integration defined as the problem oriented process (POP) was tested with 16 students over two semesters. The result... | [
-0.04354526847600937,
-0.0020753731951117516,
0.03771670162677765,
-0.023232530802488327,
-0.020286213606595993,
0.002130033215507865,
0.03820430114865303,
0.05544911324977875,
-0.01877979375422001,
-0.02146625705063343,
0.06415212899446487,
0.015284571796655655,
-0.02883145399391651,
-0.0... |
PMID:27490 | On "problems" with integrated curricula in nursing. | Curriculum development is many things; it is the study of impact on students, a process through which faculty are moving. It usually does not represent a final decision- like all issues in higher education it is altered as different people and issues arise. The integrated curriculum movement in nursing, while a seminal... | On "problems" with integrated curricula in nursing. Curriculum development is many things; it is the study of impact on students, a process through which faculty are moving. It usually does not represent a final decision- like all issues in higher education it is altered as different people and issues arise. The integr... | [
-0.03496742993593216,
-0.03408481553196907,
0.003276845207437873,
-0.005351824685931206,
-0.013471228070557117,
0.01596461422741413,
-0.06581711024045944,
0.03694206848740578,
-0.016195224598050117,
0.03735865652561188,
0.03179355710744858,
-0.0031518356408923864,
-0.017416778951883316,
-0... |
PMID:27492 | Seduction and the hospitalized person. | Seductive behavior seen in the convalescent individual is generally a signal that the patient is in the process of assessment. It is not a social invitation to sexual activity. The patient is merely trying to reassess his situation after having experienced an illness, injury or surgery. Nurses have an obligation to be ... | Seduction and the hospitalized person. Seductive behavior seen in the convalescent individual is generally a signal that the patient is in the process of assessment. It is not a social invitation to sexual activity. The patient is merely trying to reassess his situation after having experienced an illness, injury or su... | [
0.03173478692770004,
0.012327183037996292,
-0.016290081664919853,
-0.028579967096447945,
0.01531667448580265,
0.0336783304810524,
0.11727810651063919,
0.006934101227670908,
0.020970314741134644,
-0.020245371386408806,
-0.007239026483148336,
-0.011194117367267609,
-0.05617949739098549,
-0.0... |
PMID:27494 | 1-N HAPA gentamicin B, a new aminoglycoside active against gentamicin resistant isolates--activity compared to other aminoglycosides. | 1-N HAPA gentamicin B is a new aminoglycoside active against most Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. Among 504 clinical isolates at a concentration of 12.5 microgram/ml all Staph. aureus, Escherichia coli, Klebsiella, Enterobacter, Proteus rettgeri, Providencia and 78% of Pseudomonas,... | 1-N HAPA gentamicin B, a new aminoglycoside active against gentamicin resistant isolates--activity compared to other aminoglycosides. 1-N HAPA gentamicin B is a new aminoglycoside active against most Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. Among 504 clinical isolates at a concentration of ... | [
-0.0323002003133297,
-0.03662975877523422,
-0.021288692951202393,
-0.0049030110239982605,
0.06920120120048523,
-0.05419880151748657,
0.022169334813952446,
0.07869365811347961,
-0.08273965865373611,
-0.0577380396425724,
0.042066484689712524,
-0.03230706974864006,
0.014044350944459438,
0.011... |
PMID:27495 | Macrolide antibiotics M-4365 produced by Micromonospora. III. In vitro antimicrobial activity of antibiotic M-4365G2 (de-epoxy rosamicin). | Antibiotic M-4365G2 (de-epoxy rosamicin) produced by Micromonospora capillata MCRL 0940 is a new basic 16-membered macrolide antibiotic with activity equal to or superior to erythromycin and josamycin against Gram-positive bacteria. Of interest are the high degree of activity against Gram-negative bacilli and mycoplasm... | Macrolide antibiotics M-4365 produced by Micromonospora. III. In vitro antimicrobial activity of antibiotic M-4365G2 (de-epoxy rosamicin). Antibiotic M-4365G2 (de-epoxy rosamicin) produced by Micromonospora capillata MCRL 0940 is a new basic 16-membered macrolide antibiotic with activity equal to or superior to erythro... | [
-0.027655279263854027,
0.011596997268497944,
0.020327890291810036,
-0.01854194886982441,
0.014758378267288208,
-0.07116905599832535,
-0.031161082908511162,
0.04855667054653168,
-0.054116927087306976,
-0.02087392657995224,
-0.019917473196983337,
-0.049970902502536774,
0.028789091855287552,
... |
PMID:27498 | Control of ammonium assimilation in Rhizobium 32H1. | The symbiotic, nitrogen-fixing bacterium Rhizobium sp. 32H1 is a specialized ammonium producer during symbiosis. However, during free-living growth, Rhizobium 32H1 assimilates ammonium very poorly. Two pathways of ammonium assimilation exist in enteric bacteria. One is mediated by glutamate dehydrogenase, and the other... | Control of ammonium assimilation in Rhizobium 32H1. The symbiotic, nitrogen-fixing bacterium Rhizobium sp. 32H1 is a specialized ammonium producer during symbiosis. However, during free-living growth, Rhizobium 32H1 assimilates ammonium very poorly. Two pathways of ammonium assimilation exist in enteric bacteria. One i... | [
0.0050188880413770676,
-0.02332746610045433,
-0.06054568290710449,
-0.0015152766136452556,
0.05816948786377907,
-0.06550831347703934,
-0.008393633179366589,
-0.014342169277369976,
-0.04489272087812424,
0.049318552017211914,
0.031018448993563652,
-0.11307106912136078,
0.10910806059837341,
0... |
PMID:27499 | Purification and properties of a second enzyme catalyzing the splitting of carbon-mercury linkages from mercury-resistant Pseudomonas K-62. | An enzyme (splitting enzyme 2) which catalyzes the splitting of carbon-mercury linkage of arylmercury compounds was found in extracts of mercury-resistant Pseudomonas K-62. This enzyme was purified about 725-fold by treatment with streptomycin, precipitation with ammonium sulfate, and successive chromatography on Sepha... | Purification and properties of a second enzyme catalyzing the splitting of carbon-mercury linkages from mercury-resistant Pseudomonas K-62. An enzyme (splitting enzyme 2) which catalyzes the splitting of carbon-mercury linkage of arylmercury compounds was found in extracts of mercury-resistant Pseudomonas K-62. This en... | [
-0.05202338472008705,
0.023001011461019516,
-0.05952870100736618,
0.022991392761468887,
0.0677017942070961,
-0.08708114176988602,
-0.048249751329422,
0.04455672949552536,
-0.03795507922768593,
-0.008351887576282024,
-0.015565084293484688,
-0.11170981824398041,
-0.023905102163553238,
0.0326... |
PMID:27500 | Alcohol dehydrogenases from a facultative methylotrophic bacterium. | Alcohol-oxidizing enzymes of the facultative methylotroph PAR were investigated after growth of the bacteria on methanol and ethanol. During methanol growth only a phenazine methosulfate-linked alcohol dehydrogenase was detected. This enzyme had broad specificity for primary alcohols and was also capable of oxidation o... | Alcohol dehydrogenases from a facultative methylotrophic bacterium. Alcohol-oxidizing enzymes of the facultative methylotroph PAR were investigated after growth of the bacteria on methanol and ethanol. During methanol growth only a phenazine methosulfate-linked alcohol dehydrogenase was detected. This enzyme had broad ... | [
0.00038260023575276136,
0.043075982481241226,
-0.080050528049469,
-0.015556908212602139,
0.005503821186721325,
-0.04604754596948624,
-0.009121996350586414,
0.016935359686613083,
-0.02121681720018387,
-0.033331722021102905,
0.03880762681365013,
-0.07810776680707932,
-0.004065391607582569,
0... |
PMID:27501 | Glycolipids stimulate DNA polymerase activity in a DNA-membrane fraction and in a partially purified polymerase system extracted from pneumococci. | We have assayed the ability of various lipids to affect DNA polymerases activity in a DNA-membrane complex extracted from Streptococcus pneumoniae by the Sarkosyl-M-band technique. In addition, to determine which DNA polymerases were affected by the lipids, we partially purified three DNA polymerase activities from cel... | Glycolipids stimulate DNA polymerase activity in a DNA-membrane fraction and in a partially purified polymerase system extracted from pneumococci. We have assayed the ability of various lipids to affect DNA polymerases activity in a DNA-membrane complex extracted from Streptococcus pneumoniae by the Sarkosyl-M-band tec... | [
-0.04896581545472145,
-0.008310778997838497,
-0.024006973952054977,
-0.01360388845205307,
0.02051345445215702,
-0.014607477933168411,
0.02362089417874813,
0.04858532175421715,
-0.02538386546075344,
-0.033016715198755264,
0.0042418427765369415,
0.007333976216614246,
0.006421411409974098,
-0... |
PMID:27503 | EPR investigation of the Mn(II) binding sites in glutamine synthetase (Escherichia coli W). II. Intermediate-affinity binding sites. | The nature of the intermediate-affinity (n2) Mn(II) binding sites in glutamine synthetase [EC 6.3.1.2] has been studied as a function of adenylylation in a variety of enzyme-metal complexes by EPR. In the absence of nucleotide the n2 Mn(II) environment is nearly isotropic, the Mn(II) bonds are highly ionic, and the int... | EPR investigation of the Mn(II) binding sites in glutamine synthetase (Escherichia coli W). II. Intermediate-affinity binding sites. The nature of the intermediate-affinity (n2) Mn(II) binding sites in glutamine synthetase [EC 6.3.1.2] has been studied as a function of adenylylation in a variety of enzyme-metal complex... | [
-0.0736638605594635,
0.006880633998662233,
-0.06980251520872116,
0.008036903105676174,
0.08950842916965485,
-0.023275703191757202,
0.06396390497684479,
0.027659598737955093,
-0.05044230818748474,
-0.016345569863915443,
0.05657169222831726,
-0.04090048000216484,
0.022559907287359238,
0.0091... |
PMID:27504 | Use of fluorescamine-labeled casein as a substrate for assay of proteinases. | Conditions have been investigated for the use of fluorescamine-labeled casein as a substrate for fluorometric assay of proteinases. Fluorescamine-labeled casein can be prepared simply by mixing solutions of casein and fluorescamine at pH 8.0 and used without removal of the excess reagent or its hydrolysis product. The ... | Use of fluorescamine-labeled casein as a substrate for assay of proteinases. Conditions have been investigated for the use of fluorescamine-labeled casein as a substrate for fluorometric assay of proteinases. Fluorescamine-labeled casein can be prepared simply by mixing solutions of casein and fluorescamine at pH 8.0 a... | [
-0.05978134274482727,
-0.06688039749860764,
-0.026410674676299095,
0.005747570190578699,
0.02878609672188759,
-0.04002035781741142,
0.07505062967538834,
0.05281228572130203,
-0.026324734091758728,
-0.02170533873140812,
-0.030231263488531113,
-0.08131781965494156,
-0.0005072561325505376,
0.... |
PMID:27506 | Heat activation of rat liver acetyl-CoA carboxylase in vitro. | Acetyl-CoA carboxylase in rat liver homogenates was activated in vitro in a time- and temperature-dependent manner. The activity of acetyl-CoA carboxylase in rat liver preparations was determined in a 1-min assay to preclude the possibility of citrate activation of the enzyme during the assay period. Activation of the ... | Heat activation of rat liver acetyl-CoA carboxylase in vitro. Acetyl-CoA carboxylase in rat liver homogenates was activated in vitro in a time- and temperature-dependent manner. The activity of acetyl-CoA carboxylase in rat liver preparations was determined in a 1-min assay to preclude the possibility of citrate activa... | [
-0.04954451322555542,
-0.023642418906092644,
-0.00827948097139597,
0.004089981317520142,
0.028125347569584846,
0.026432707905769348,
0.07782534509897232,
0.019818823784589767,
-0.06964751332998276,
-0.05580346658825874,
0.0351572148501873,
-0.02992360293865204,
0.02173900231719017,
0.04627... |
PMID:27507 | Transglutaminase-catalyzed cross-linking through diamines and polyamines. | Transglutaminases were found to catalyze the formation of cross-links between peptide chains by means of a transfer reaction between the carboxamide group of a glutamine residue in each chain and both primary amino groups of a diamine or a polyamine. Production of this heretofore undescribed linkage by guinea pig liver... | Transglutaminase-catalyzed cross-linking through diamines and polyamines. Transglutaminases were found to catalyze the formation of cross-links between peptide chains by means of a transfer reaction between the carboxamide group of a glutamine residue in each chain and both primary amino groups of a diamine or a polyam... | [
-0.0461004264652729,
0.014700247906148434,
-0.05678931623697281,
0.02828488126397133,
0.009201668202877045,
-0.0017392156878486276,
0.08169298619031906,
0.03373974934220314,
-0.04693354293704033,
-0.02190134860575199,
-0.0255446657538414,
-0.057655733078718185,
0.004291456658393145,
0.1109... |
PMID:27508 | Direct inhibition of tyrosine hydroxylase activity by catechol estrogens. | Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. The nature of the inhibition is by competition with the pterin cofacto... | Direct inhibition of tyrosine hydroxylase activity by catechol estrogens. Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephri... | [
-0.009360797703266144,
-0.0004407406959217042,
-0.07308676093816757,
0.05418126657605171,
-0.021813414990901947,
0.0208787452429533,
0.04634513705968857,
0.004984610248357058,
0.015259669162333012,
-0.02130744792521,
-0.003856998635455966,
-0.03663674369454384,
0.0030239818152040243,
0.049... |
PMID:27511 | Determination of glucose oxidase oxidation-reduction potentials and the oxygen reactivity of fully reduced and semiquinoid forms. | The oxidation-reduction potential values for the two electron transfers to glucose oxidase were obtained at pH 5.3, where the neutral radical is the stable form, and at pH 9.3, where the anion radical is the stable form. The midpoint potentials at 25 degrees were: pH 5.3 EFl1ox + e- H+ equilibrium EFlH. Em1 = -0.063 +/... | Determination of glucose oxidase oxidation-reduction potentials and the oxygen reactivity of fully reduced and semiquinoid forms. The oxidation-reduction potential values for the two electron transfers to glucose oxidase were obtained at pH 5.3, where the neutral radical is the stable form, and at pH 9.3, where the ani... | [
-0.1192123293876648,
0.029879001900553703,
-0.021452995017170906,
0.04167340323328972,
0.01960562914609909,
0.02361021563410759,
0.0023368841502815485,
0.028168099001049995,
-0.04892827942967415,
-0.01143933180719614,
-0.04332419112324715,
-0.027571188285946846,
0.016924170777201653,
0.024... |
PMID:27512 | Dependence of the catalytic activity of papain on the ionization of two acidic groups. | The pH dependence of kcat/Km for the papain-catalyzed hydrolysis of ethyl hippurate, N-alpha-benzoyl-L-citrulline methyl ester, and the p-nitroanilide, amide, and ethyl ester derivatives of N-alpha-benzoyl-L-arginine was determined below pH 6.4. The value of kcat/Km was observed to be modulated by two acid ionizations ... | Dependence of the catalytic activity of papain on the ionization of two acidic groups. The pH dependence of kcat/Km for the papain-catalyzed hydrolysis of ethyl hippurate, N-alpha-benzoyl-L-citrulline methyl ester, and the p-nitroanilide, amide, and ethyl ester derivatives of N-alpha-benzoyl-L-arginine was determined b... | [
-0.06396516412496567,
0.03066174127161503,
-0.04075292497873306,
0.029003020375967026,
0.024501599371433258,
-0.03914237767457962,
0.031433869153261185,
0.011319342069327831,
-0.013652173802256584,
0.016626108437776566,
0.034326836466789246,
-0.04754902794957161,
-0.019619204103946686,
0.0... |
PMID:27515 | Multiple phosphorylation of acetyl-CoA carboxylase in chick liver cells. A cyclic AMP-independent process. | When chick liver cells in monolayer culture were incubated with 32Pi in the presence of insulin, acetyl-CoA carboxylase became extensively labeled with 32Pi reaching a stoichiometry of 9 to 10 mol of phosphoryl group per mol of 240,000-dalton enzyme subunit. The covalently bound phosphate was found to be metabolically ... | Multiple phosphorylation of acetyl-CoA carboxylase in chick liver cells. A cyclic AMP-independent process. When chick liver cells in monolayer culture were incubated with 32Pi in the presence of insulin, acetyl-CoA carboxylase became extensively labeled with 32Pi reaching a stoichiometry of 9 to 10 mol of phosphoryl gr... | [
-0.052723534405231476,
-0.07572581619024277,
-0.04242223873734474,
-0.0010774618713185191,
0.005983780603855848,
-0.0007135419873520732,
0.03572724759578705,
0.0065370709635317326,
-0.07318002730607986,
-0.039110202342271805,
0.07243742793798447,
-0.07318314164876938,
0.002900500316172838,
... |
PMID:27516 | Metabolism of prostacyclin in blood vessels. | The activity of 15-hydroxyprostaglandin dehydrogenase has been shown to be high in both mesenteric arteries and veins; the present study suggests that it may be responsible for the inactivation of prostacyclin (PGI2). The cytoplasmic fractions of bovine mesenteric arteries and veins were incubated with radiolabeled PGI... | Metabolism of prostacyclin in blood vessels. The activity of 15-hydroxyprostaglandin dehydrogenase has been shown to be high in both mesenteric arteries and veins; the present study suggests that it may be responsible for the inactivation of prostacyclin (PGI2). The cytoplasmic fractions of bovine mesenteric arteries a... | [
-0.040524985641241074,
0.014245922677218914,
-0.04664384946227074,
-0.02199435420334339,
-0.0010437091113999486,
-0.014163566753268242,
0.020561859011650085,
0.04193969815969467,
-0.010383957996964455,
-0.022809458896517754,
0.07024634629487991,
-0.06424225866794586,
0.014358880929648876,
... |
PMID:27518 | Effects of pH and temperature on the interaction of an impermeant probe with surface proteins of the human red blood cell. | The conformation of the outer surface of the human red cell membrane has been studied under various conditions using the impermeant probe [125I]diazodiiodosulfanilic acid. At least seven polypeptides were labeled by the reagent, including the three extractable glycoproteins separable by the electrophoretic method emplo... | Effects of pH and temperature on the interaction of an impermeant probe with surface proteins of the human red blood cell. The conformation of the outer surface of the human red cell membrane has been studied under various conditions using the impermeant probe [125I]diazodiiodosulfanilic acid. At least seven polypeptid... | [
-0.0896395817399025,
-0.018162455409765244,
-0.008350075222551823,
0.03427248075604439,
0.018251612782478333,
-0.030646877363324165,
0.09947405755519867,
0.034994471818208694,
-0.05626310780644417,
-0.0016394720878452063,
0.023525696247816086,
-0.07127094268798828,
-0.008064054884016514,
0... |
PMID:27519 | Solvent effects on the structure of rabbit Clq, a subcomponent of the first component of complement. | The effect of solvent conditions on the conformation of rabbit Clq was studied by both spectroscopic and nonspectroscopic methods. The conformation of Clq in buffered saline solutions at pH 7.4 or 6.0 did not differ significantly from Clq at twice the saline concentration as determined with circular dichroism, differen... | Solvent effects on the structure of rabbit Clq, a subcomponent of the first component of complement. The effect of solvent conditions on the conformation of rabbit Clq was studied by both spectroscopic and nonspectroscopic methods. The conformation of Clq in buffered saline solutions at pH 7.4 or 6.0 did not differ sig... | [
-0.09949617087841034,
-0.03211621940135956,
-0.035495806485414505,
0.07612879574298859,
-0.01133180782198906,
0.005685350392013788,
0.08627331256866455,
0.027204032987356186,
-0.03788553550839424,
-0.024389222264289856,
0.027178624644875526,
-0.07510681450366974,
-0.002398815006017685,
0.0... |
PMID:27520 | Leghemoglobin. Low temperature optical spectra of acid and alkaline forms of leghemoglobin(IV). Configuration of the heme. | Leghemoglobin(IV), the derivative of leghemoglobin at the formal oxidation state IV, when cooled to liquid nitrogen temperature exhibits radically different spectra at acid and alkaline pH. The acid and alkaline forms are freely interconvertible. The optical spectrum of the acid form is closely similar to optical spect... | Leghemoglobin. Low temperature optical spectra of acid and alkaline forms of leghemoglobin(IV). Configuration of the heme. Leghemoglobin(IV), the derivative of leghemoglobin at the formal oxidation state IV, when cooled to liquid nitrogen temperature exhibits radically different spectra at acid and alkaline pH. The aci... | [
-0.1096951887011528,
0.04630982130765915,
-0.010774271562695503,
0.047391269356012344,
0.04411722347140312,
-0.03512546047568321,
0.06126369535923004,
0.06060254946351051,
-0.026380274444818497,
0.013850542716681957,
0.008899157866835594,
-0.08169324696063995,
-0.005489325150847435,
0.0109... |
PMID:27521 | Acid and alkaline forms of the higher oxidation state of kangaroo, horse, and sperm whale myoglobin. | Myoglobin(IV), the derivative of myoglobin at the formal oxidation state IV, prepared from kangaroo (Megaleia rufa), horse, or sperm whale myoglobin, when cooled to liquid nitrogen temperature, assumes acid and alkaline forms with different optical spectra. The essential features of the optical spectra of the acid form... | Acid and alkaline forms of the higher oxidation state of kangaroo, horse, and sperm whale myoglobin. Myoglobin(IV), the derivative of myoglobin at the formal oxidation state IV, prepared from kangaroo (Megaleia rufa), horse, or sperm whale myoglobin, when cooled to liquid nitrogen temperature, assumes acid and alkaline... | [
-0.08136089146137238,
0.032223016023635864,
-0.02268795669078827,
0.03957052901387215,
0.017483895644545555,
-0.02349761687219143,
0.07664971053600311,
0.0506029836833477,
-0.04106120392680168,
0.05025665834546089,
0.012769736349582672,
-0.08601152151823044,
-0.006150637753307819,
0.015184... |
PMID:27523 | Molecular properties of a major cell surface protein from chick embryo fibroblasts. | The molecular structure of chick embryo fibroblast cell surface protein has been investigated by ultracentrifugation, circular dichroism, and fluorescence. Most measurements were restricted to alkaline solutions because of the limited solubility of this protein at more neutral pH values. A very high frictional ratio fo... | Molecular properties of a major cell surface protein from chick embryo fibroblasts. The molecular structure of chick embryo fibroblast cell surface protein has been investigated by ultracentrifugation, circular dichroism, and fluorescence. Most measurements were restricted to alkaline solutions because of the limited s... | [
-0.06668318063020706,
-0.04846501350402832,
-0.00517314113676548,
0.00607692776247859,
-0.0025829265359789133,
0.057523615658283234,
0.02569163590669632,
0.026098955422639847,
-0.004149666987359524,
0.011053678579628468,
0.00492458138614893,
-0.053095076233148575,
-0.02848527580499649,
0.0... |
PMID:27524 | Rupture of the plantar fascia in athletes. | Symptoms resembling those of plantar fasciitis were seen in six athletes who were thought to have a partial rupture of the plantar fascia. Treatment, which included the use of crutches, anti-inflammatory agents, strapping of the arch, and ice packs, was successful in all but one patient who had a painful mass in the ar... | Rupture of the plantar fascia in athletes. Symptoms resembling those of plantar fasciitis were seen in six athletes who were thought to have a partial rupture of the plantar fascia. Treatment, which included the use of crutches, anti-inflammatory agents, strapping of the arch, and ice packs, was successful in all but o... | [
0.0008426086860708892,
-0.0636039674282074,
0.03528660535812378,
0.010942615568637848,
0.007742517162114382,
0.053019553422927856,
0.03833843767642975,
0.12211713194847107,
-0.053820330649614334,
-0.0066467467695474625,
0.03402765467762947,
-0.07070933282375336,
-0.03176160156726837,
0.001... |
PMID:27525 | Glucocorticoid induction of tyrosine hydroxylase in a continous cell line of rat pheochromocytoma. | We have established a continous cell line (G1) in which the tyrosine hydroxylase specific activity is increased as much as 50-100-fold in response to dexamethasone. This response is specific for the glucocorticoid class of steroid hormones; it is elicited by dexamethasone, corticosterone, and triamcinolone, but not by ... | Glucocorticoid induction of tyrosine hydroxylase in a continous cell line of rat pheochromocytoma. We have established a continous cell line (G1) in which the tyrosine hydroxylase specific activity is increased as much as 50-100-fold in response to dexamethasone. This response is specific for the glucocorticoid class o... | [
-0.023650456219911575,
0.0033380603417754173,
-0.024592934176325798,
0.03803360462188721,
-0.006937474478036165,
-0.020127495750784874,
0.049790963530540466,
0.007158651947975159,
-0.026048777624964714,
-0.02343113347887993,
0.010365198366343975,
-0.013238518498837948,
-0.0134576465934515,
... |
PMID:27526 | Inhibition of glucose transport in human erythrocytes by benzylalcohol. | The inhibition of glucose transport by the non-ionizable local-anesthetic denzylalcohol is of the mixed type and independent of pH. The affinity of benzylalcohol to the free carrier is about three times larger than that to the carrier-glucose complex. | Inhibition of glucose transport in human erythrocytes by benzylalcohol. The inhibition of glucose transport by the non-ionizable local-anesthetic denzylalcohol is of the mixed type and independent of pH. The affinity of benzylalcohol to the free carrier is about three times larger than that to the carrier-glucose compl... | [
-0.05219564959406853,
-0.04827197268605232,
-0.03863881900906563,
0.06593725085258484,
-0.008810204453766346,
-0.023711860179901123,
0.07939108461141586,
0.019511494785547256,
-0.06596366316080093,
-0.019935129210352898,
-0.0000932342154555954,
-0.03440029174089432,
-0.0607210174202919,
0.... |
PMID:27527 | Culture pH, CO2 tension, and cell division in Euglena gracilis Z. | Growth characteristics of Euglena gracilis Z as functions of culture pH, CO2 tension, temperature, and lighting regime were investigated. The results are consistent with the possibility that cell division is preceded by a lowered intracellular pH. Also consistent with this possibility is the finding that division rhyth... | Culture pH, CO2 tension, and cell division in Euglena gracilis Z. Growth characteristics of Euglena gracilis Z as functions of culture pH, CO2 tension, temperature, and lighting regime were investigated. The results are consistent with the possibility that cell division is preceded by a lowered intracellular pH. Also c... | [
-0.021338939666748047,
-0.006042714696377516,
0.0020136074163019657,
0.043906744569540024,
0.03804009407758713,
-0.02331630140542984,
0.04689629375934601,
0.01295852568000555,
-0.04828416928648949,
0.007893431931734085,
0.021387863904237747,
-0.07950685918331146,
-0.008799828588962555,
0.0... |
PMID:27528 | Effects of acidified fetal bovine serum on the fibrinolytic activity and growth of cells in culture. | The fibrinolytic activity of cells in culture varied with the type of serum employed in the growth medium. Degradation of iodinated fibrin occurred slowly when Rous sarcoma virus-transformed chick embryo fibroblasts were grown in medium containing fetal bovine serum (FBS), and rapidly when chicken serum was employed. T... | Effects of acidified fetal bovine serum on the fibrinolytic activity and growth of cells in culture. The fibrinolytic activity of cells in culture varied with the type of serum employed in the growth medium. Degradation of iodinated fibrin occurred slowly when Rous sarcoma virus-transformed chick embryo fibroblasts wer... | [
-0.029949910938739777,
-0.008304273709654808,
-0.021854650229215622,
-0.00011369674029992893,
0.037500012665987015,
0.015286039561033249,
0.03945253789424896,
0.04707193374633789,
-0.036008261144161224,
-0.006492943037301302,
0.02404177375137806,
-0.10476266592741013,
-0.03615425527095795,
... |
PMID:27530 | Effects of methylprednisolone on hydrogen ion absorption in the canine stomach. | The effect of methylprednisolone (2 mg/kg per day given parenterally for 3 doses, 2 wk or 12 wk) on the permeability of mammalian gastric mucosa to hydrogen ion (H(+)) was examined with denervated fundic pouches in dogs with antrectomies. Transmucosal electric potential difference (PD) and net fluxes of H(+) and Na(+) ... | Effects of methylprednisolone on hydrogen ion absorption in the canine stomach. The effect of methylprednisolone (2 mg/kg per day given parenterally for 3 doses, 2 wk or 12 wk) on the permeability of mammalian gastric mucosa to hydrogen ion (H(+)) was examined with denervated fundic pouches in dogs with antrectomies. T... | [
-0.02818858064711094,
-0.05124422907829285,
0.006635366007685661,
0.04701017215847969,
0.011867644265294075,
-0.018510431051254272,
0.02645890600979328,
0.014254492707550526,
-0.03823507949709892,
-0.04404059424996376,
-0.03255831077694893,
-0.10026387125253677,
0.005554127041250467,
0.012... |
PMID:27531 | The role of acetaldehyde in mediating the deleterious effect of ethanol on pyridoxal 5'-phosphate metabolism. | Previous studies in vivo and with isolated perfused rat livers have suggested that the deleterious effect of ethanol on hepatic pyridoxal 5'-phosphate metabolism is mediated by acetaldehyde. Inasmuch as acetaldehyde has no effect on the synthesis of pyridoxal phosphate, it has also been postulated that acetaldehyde acc... | The role of acetaldehyde in mediating the deleterious effect of ethanol on pyridoxal 5'-phosphate metabolism. Previous studies in vivo and with isolated perfused rat livers have suggested that the deleterious effect of ethanol on hepatic pyridoxal 5'-phosphate metabolism is mediated by acetaldehyde. Inasmuch as acetald... | [
-0.030824309214949608,
0.049572933465242386,
-0.009457569569349289,
-0.007347795180976391,
0.04037006199359894,
-0.020708100870251656,
0.02358609437942505,
0.03072504699230194,
-0.06429973244667053,
-0.014481822028756142,
0.03891930356621742,
-0.002876386744901538,
0.049015697091817856,
0.... |
PMID:27532 | Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties. | In the erythrocytes of a patient with hereditary nonspherocytic hemolytic anemia, a homozygous expression of hexokinase deficiency was detected. The mutant enzyme was characterized by normal kinetic parameters with respect to its substrates, glucose and MgATP2-, normal pH optimum, normal heat stability at 40 degrees C,... | Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with abnormal regulatory properties. In the erythrocytes of a patient with hereditary nonspherocytic hemolytic anemia, a homozygous expression of hexokinase deficiency was detected. The mutant enzyme was characterized by normal kinetic paramet... | [
-0.08522215485572815,
0.06005677208304405,
0.004520218353718519,
0.022605452686548233,
-0.03251395374536514,
0.009113370440900326,
0.06263767927885056,
0.02899126335978508,
-0.06303433328866959,
0.026360945776104927,
-0.0256288293749094,
-0.0660245344042778,
-0.05624737590551376,
0.0553537... |
PMID:27533 | Passive transfer by cells of type II collagen-induced arthritis in rats. | To investigate the role of immunologic hypersensitivity to collagen in the causation of type II collagen-induced arthritis in rats, passive transfer experiments were performed. Wistar/Lewis rats used in these experiments were demonstrated to be histocompatible by prolonged skin graft survival and mixed lymphocyte cultu... | Passive transfer by cells of type II collagen-induced arthritis in rats. To investigate the role of immunologic hypersensitivity to collagen in the causation of type II collagen-induced arthritis in rats, passive transfer experiments were performed. Wistar/Lewis rats used in these experiments were demonstrated to be hi... | [
-0.02395080029964447,
-0.02113574557006359,
0.0064195916056632996,
0.028596946969628334,
0.0077069951221346855,
-0.005364245735108852,
0.05915224924683571,
0.06167841702699661,
-0.06020234525203705,
-0.0551408976316452,
0.016954073682427406,
-0.06315604597330093,
0.033066119998693466,
0.00... |
PMID:27534 | The effect of complement depletion on lung clearance of bacteria. | We have investigated the effect of hypocomplementemia on early pulmonary clearance of four species of bacteria. The experiments were performed in an inbred animal model to minimize immunologic variability. Complement was depleted by cobra venom factor, and activity in serum was monitored with a phagocytic assay. Bacter... | The effect of complement depletion on lung clearance of bacteria. We have investigated the effect of hypocomplementemia on early pulmonary clearance of four species of bacteria. The experiments were performed in an inbred animal model to minimize immunologic variability. Complement was depleted by cobra venom factor, a... | [
-0.06177378445863724,
0.05253180116415024,
-0.017258912324905396,
0.009992704726755619,
0.03852106258273125,
-0.018363405019044876,
0.07334469258785248,
0.03387194499373436,
-0.017204608768224716,
0.0234079509973526,
0.0014573693042621017,
-0.09554413706064224,
0.029283160343766212,
0.0019... |
PMID:27535 | Effects of alpha adrenergic blockade upon coronary hemodynamics. | The effect of alpha adrenergic block-ade on coronary blood flow regulation at rest was studied in 11 normally innervated patients and 8 cardiac allograft recipients by measuring arterial pressure and coronary sinus blood flow by thermodilution before and after alpha adrenergic blockade with phentolamine. Coronary vascu... | Effects of alpha adrenergic blockade upon coronary hemodynamics. The effect of alpha adrenergic block-ade on coronary blood flow regulation at rest was studied in 11 normally innervated patients and 8 cardiac allograft recipients by measuring arterial pressure and coronary sinus blood flow by thermodilution before and ... | [
-0.028817223384976387,
0.028099942952394485,
0.0037030107341706753,
0.05582979694008827,
0.007169818971306086,
-0.013383441604673862,
0.08405569195747375,
-0.007569196168333292,
-0.007232379633933306,
-0.030146395787596703,
-0.020664481446146965,
-0.05908709764480591,
-0.046641167253255844,
... |
PMID:27536 | gamma-Glutamyl transferase isoenzymes in human bile. | The gamma-glutamyl transferase isoenzymes of bile were studied using electrophoretic, gel filtration, and ultracentrifugation techniques. In view of the known association of other biliary enzymes with lipids the effects of butanol extraction were investigated. The results show the presence of four isoenzymes of gamma-g... | gamma-Glutamyl transferase isoenzymes in human bile. The gamma-glutamyl transferase isoenzymes of bile were studied using electrophoretic, gel filtration, and ultracentrifugation techniques. In view of the known association of other biliary enzymes with lipids the effects of butanol extraction were investigated. The re... | [
0.03499826788902283,
-0.02903377264738083,
-0.03537542000412941,
0.029139194637537003,
-0.0009095676359720528,
-0.031332746148109436,
0.06745569407939911,
0.08156068623065948,
-0.026338869705796242,
-0.033662475645542145,
0.021968381479382515,
-0.05964129418134689,
0.009439893998205662,
-0... |
PMID:27537 | Plasma levels of clobazam after three oral dosage forms in health subjects. | As can be seen from the tables, the terminal half-life of clobazam is about 50 hours, and from a solid dosage form the peak plasma level occurs approximately 1.5 hours after ingestion. Thus, there is a significant, yet relatively short, dosage form delay effect when the solid dosage forms are compared to the rapidly av... | Plasma levels of clobazam after three oral dosage forms in health subjects. As can be seen from the tables, the terminal half-life of clobazam is about 50 hours, and from a solid dosage form the peak plasma level occurs approximately 1.5 hours after ingestion. Thus, there is a significant, yet relatively short, dosage ... | [
-0.05991160497069359,
0.04255731403827667,
0.05247270688414574,
0.0410718098282814,
-0.026876503601670265,
0.027178656309843063,
0.04872904345393181,
0.028900200501084328,
-0.06307440251111984,
-0.022660937160253525,
0.01627013087272644,
-0.05479617789387703,
0.024498455226421356,
0.036363... |
PMID:27539 | Clobazam versus diazepam--a double-blind study in anxiety neurosis. | Clobazam, a new antianxiety compound, was compared in a double-blind study with diazepam in 40 neurotic outpatients. Twenty-three patients completed the trial under clobazam conditions while 17 patients completed the trial under diazepam conditions. The trial was conducted for a period of four weeks of active drug adm... | Clobazam versus diazepam--a double-blind study in anxiety neurosis. Clobazam, a new antianxiety compound, was compared in a double-blind study with diazepam in 40 neurotic outpatients. Twenty-three patients completed the trial under clobazam conditions while 17 patients completed the trial under diazepam conditions. T... | [
-0.0026343504432588816,
0.01172720082104206,
-0.0010725539177656174,
0.09370698779821396,
0.02553500048816204,
0.03732144087553024,
0.05322569981217384,
0.026239007711410522,
-0.03568601235747337,
-0.07134835422039032,
-0.013262525200843811,
-0.011507783085107803,
0.005660658702254295,
-0.... |
PMID:27542 | Lactostrepcins--acid bacteriocins produced by lactic streptococci. | All 47 non-nisin producing strains of Streptococcus lactis and 12/13 strains of Str. lactis subsp. diacetylactis examined produced bacteriocins, for which the term lactostrepcins is suggested. Seven strains of Str. cremoris examined produced no bacteriocins active against 3 lactic streptococci strains used as indicator... | Lactostrepcins--acid bacteriocins produced by lactic streptococci. All 47 non-nisin producing strains of Streptococcus lactis and 12/13 strains of Str. lactis subsp. diacetylactis examined produced bacteriocins, for which the term lactostrepcins is suggested. Seven strains of Str. cremoris examined produced no bacterio... | [
-0.03699982538819313,
-0.04754742980003357,
0.013412092812359333,
-0.005643290933221579,
-0.008531608618795872,
-0.044117800891399384,
0.020317869260907173,
0.08825469762086868,
-0.06864295899868011,
-0.02662643790245056,
-0.003385684685781598,
-0.0417124480009079,
0.018829945474863052,
0.... |
PMID:27544 | Blood and tissue distribution of gamma glutamyl transferase in calves. | In five male and five female calves, we studied the tissue distribution of gamma-glutamyl transferase. The enzyme was mainly in kidney, pancreas, and liver; there was no sex-related difference. The relative hepatic and pancreatic specificity of the enzyme indicated that the measure of its activity in serum could be a t... | Blood and tissue distribution of gamma glutamyl transferase in calves. In five male and five female calves, we studied the tissue distribution of gamma-glutamyl transferase. The enzyme was mainly in kidney, pancreas, and liver; there was no sex-related difference. The relative hepatic and pancreatic specificity of the ... | [
0.049996692687273026,
-0.018288159742951393,
0.013175136409699917,
-0.009742313995957375,
0.030689891427755356,
0.0035887076519429684,
0.06695389002561569,
0.0800999104976654,
0.005660191178321838,
-0.00649626087397337,
-0.0034846330527216196,
-0.08554607629776001,
0.010603681206703186,
-0... |
PMID:27545 | Nutrition policy--from neglect and uncertainty to debate and action. | Until recent years, nutrition has received little attention in U.S. agriculture, food, and health policies. This circumstance is changing. In the late sixties and early seventies, reports of hunger and malnutrition sparked public reaction and a shift in policy. The White House Conference on Food, Nutrition and Health i... | Nutrition policy--from neglect and uncertainty to debate and action. Until recent years, nutrition has received little attention in U.S. agriculture, food, and health policies. This circumstance is changing. In the late sixties and early seventies, reports of hunger and malnutrition sparked public reaction and a shift ... | [
-0.07192104309797287,
0.027029884979128838,
0.0053094532340765,
0.0010598041117191315,
0.03152741119265556,
0.09296762198209763,
-0.007845018990337849,
0.023505568504333496,
-0.05107392370700836,
0.035835303366184235,
0.0631713941693306,
-0.044155389070510864,
0.028948316350579262,
0.03443... |
PMID:27546 | Comparison of oxazepam, flurazepam and chloral hydrate as hypnotic sedatives in geriatric patients. | In a four-week study, a comparison was made of oxazepam, flurazepam and chloral hydrate as hypnotic sedatives in 17 geriatric patients. Each drug was given alone for six nights, with a two-night placebo interval following each phase. Each patient completed an additional placebo phase (up to six nights) before each drug... | Comparison of oxazepam, flurazepam and chloral hydrate as hypnotic sedatives in geriatric patients. In a four-week study, a comparison was made of oxazepam, flurazepam and chloral hydrate as hypnotic sedatives in 17 geriatric patients. Each drug was given alone for six nights, with a two-night placebo interval followin... | [
-0.02253429964184761,
-0.008197708986699581,
0.02013956569135189,
0.020938286557793617,
0.027436336502432823,
0.02974582090973854,
0.06115599349141121,
0.0018627337412908673,
0.003082882845774293,
-0.0671917200088501,
-0.06983259320259094,
0.034442465752363205,
-0.024212181568145752,
0.024... |
PMID:27558 | Antibodies of restricted heterogeneity directed against the cardiac glycoside digoxin. | Intravenous injection of New Zealand White rabbits with type III pneumococcal polysaccharide vaccine conjugated with the cardiac glycoside digoxin resulted in the production of both antidigoxin and anti-type III pneumococcal polysacharide antibodies. Among antisera of 12 rabbits examined during their peak antibody prod... | Antibodies of restricted heterogeneity directed against the cardiac glycoside digoxin. Intravenous injection of New Zealand White rabbits with type III pneumococcal polysaccharide vaccine conjugated with the cardiac glycoside digoxin resulted in the production of both antidigoxin and anti-type III pneumococcal polysach... | [
-0.07168630510568619,
-0.015582363121211529,
-0.0290071964263916,
0.012718350626528263,
0.007410050835460424,
0.02882169559597969,
0.013650357723236084,
0.0193215012550354,
-0.07546689361333847,
-0.014530747197568417,
0.005160517059266567,
-0.08031685650348663,
0.031152240931987762,
-0.035... |
PMID:27560 | Toxicity of Na251CrO4 when used to label rat lymphocytes. | Lymphocytes preincubated with various activities of Na251CrO4 were tested for their ability to induce a local, popliteal lymph node graft-versus-host (GVH) reaction. Incubation with 100 micronCi of the isotope per ml of cell suspension impaired the GVH activity, 25 micronCi gave a reduced response in 1 out of 3 experim... | Toxicity of Na251CrO4 when used to label rat lymphocytes. Lymphocytes preincubated with various activities of Na251CrO4 were tested for their ability to induce a local, popliteal lymph node graft-versus-host (GVH) reaction. Incubation with 100 micronCi of the isotope per ml of cell suspension impaired the GVH activity,... | [
-0.013482554815709591,
-0.011486818082630634,
-0.028562109917402267,
0.03481588885188103,
0.005344581324607134,
-0.03575374186038971,
0.049025002866983414,
0.03897901624441147,
-0.05435767397284508,
-0.002164512174203992,
0.004304141271859407,
-0.040716543793678284,
0.030070263892412186,
0... |
PMID:27561 | Separation and characterization of anti-benzylpenicilloyl (BPO) antibodies. I. Biochemical and biophysical properties of anti-BPO-IgG obtained by affinity and subsequent ion-exchange chromatography. | Anti-BPO antibodies were purified by means of affinity chromatography using AH-Sepharose 4B coated with covalently bound BPO groups. Specific elution was achieved by the hapten analogue BPO-epsilon-aminocaproic acid (BPO-EACA); desorption of the remaining antibody was performed thereafter by 0.1 M acetic acid. The resu... | Separation and characterization of anti-benzylpenicilloyl (BPO) antibodies. I. Biochemical and biophysical properties of anti-BPO-IgG obtained by affinity and subsequent ion-exchange chromatography. Anti-BPO antibodies were purified by means of affinity chromatography using AH-Sepharose 4B coated with covalently bound ... | [
-0.11019566655158997,
-0.005290771834552288,
-0.059758272022008896,
0.027461299672722816,
-0.011692634783685207,
-0.034096043556928635,
0.04254665970802307,
0.05738912895321846,
-0.07386340200901031,
0.01872449740767479,
0.0024672537110745907,
-0.05716140940785408,
0.0007772963144816458,
-... |
PMID:27562 | The indirect assay for leukocyte migration inhibitory factor (LIF)--standardization and the effect of pH. | In the indirect assay for leukocyte migration inhibitory factor (LIF), lymphokine-rich supernatants were obtained by culture of stimulated lymphocytes and then tested for LIF activity in agarose plates using purified granulocytes as target cells. Studies on the standardization of the conditions under which LIF acts on ... | The indirect assay for leukocyte migration inhibitory factor (LIF)--standardization and the effect of pH. In the indirect assay for leukocyte migration inhibitory factor (LIF), lymphokine-rich supernatants were obtained by culture of stimulated lymphocytes and then tested for LIF activity in agarose plates using purifi... | [
-0.07315672934055328,
-0.009035469964146614,
-0.07103254646062851,
-0.011456083506345749,
0.022305861115455627,
0.02641286328434944,
0.07297030836343765,
0.050258271396160126,
-0.05025213584303856,
-0.009938998147845268,
0.019156955182552338,
-0.03552504628896713,
0.027691537514328957,
-0.... |
PMID:27565 | Studies on the characterization of isolated renin-containing granules: the storage form of renin. | Renin-containing granules isolated by isopycnic zonal centrifugation were partially characterized biochemically. Extracts of the granules were found to have a dual pH optimum at 5.5-6.0 and 7.0-7.5 and possess linear time-dependence of product formation when reacted with homologous renin substrate. Extracts also posses... | Studies on the characterization of isolated renin-containing granules: the storage form of renin. Renin-containing granules isolated by isopycnic zonal centrifugation were partially characterized biochemically. Extracts of the granules were found to have a dual pH optimum at 5.5-6.0 and 7.0-7.5 and possess linear time-... | [
-0.08135587722063065,
0.004967255052179098,
0.009037405252456665,
0.0049886032938957214,
0.021436793729662895,
-0.026354141533374786,
0.05145654082298279,
0.05199447274208069,
-0.022523455321788788,
0.014643225818872452,
-0.012617574073374271,
-0.015436056070029736,
0.05917573347687721,
0.... |
PMID:27568 | Enrichment of in vitro and in vivo immunologic activity of purified fractions of calf thymic hormone. | Thymus humoral factor (THF), a thymus hormone which participates in the processes leading to acquisition of immunocompetence of lymphoid cells has been isolated in our laboratory by a stepwise gel filtration through various Sephadex columns. THF so isolated appears to be a polypeptide of 3,000 mol wt which contains app... | Enrichment of in vitro and in vivo immunologic activity of purified fractions of calf thymic hormone. Thymus humoral factor (THF), a thymus hormone which participates in the processes leading to acquisition of immunocompetence of lymphoid cells has been isolated in our laboratory by a stepwise gel filtration through va... | [
-0.05548306554555893,
0.015481917187571526,
-0.0471811480820179,
0.0038131303153932095,
0.027042053639888763,
0.0018850374035537243,
0.0751899778842926,
0.042727041989564896,
-0.06514007598161697,
0.005181161221116781,
-0.029300177469849586,
-0.1049543023109436,
0.028654705733060837,
0.012... |
PMID:27569 | Determination of perazine serum levels by gas liquid chromatography under clinical routine conditions. | A quantitative gas liquid chromatographic method for the determination of serum levels of perazine (10-[3'-(1''-methyl-4''-piperazinyl)-propyl]-phenothiazine) is described. Perazine is used as a neuroleptic drug. The main problem consists in optimizing the chromatographic system. A sensitivity of appr. 60--150 nmol/1 (... | Determination of perazine serum levels by gas liquid chromatography under clinical routine conditions. A quantitative gas liquid chromatographic method for the determination of serum levels of perazine (10-[3'-(1''-methyl-4''-piperazinyl)-propyl]-phenothiazine) is described. Perazine is used as a neuroleptic drug. The ... | [
-0.07918428629636765,
0.0543336383998394,
-0.035209886729717255,
0.010545574128627777,
0.006673028692603111,
0.04465610533952713,
0.062050528824329376,
0.05616817623376846,
-0.04964121803641319,
-0.0459410734474659,
0.004711513873189688,
-0.050357818603515625,
0.008734801784157753,
0.07905... |
PMID:27570 | Increased urinary excretion of keratan sulfate in fucosidosis. | In two children exhibiting the clinical symptoms of fucosidosis, the diagnosis was biochemically ascertained by the demonstration of a profound altpha-L-fucosidase deficiency in cultured skin fibroblasts. The non-dialysed urines of these fucosidosis patients were separated into two fractions by chromatography on Biogel... | Increased urinary excretion of keratan sulfate in fucosidosis. In two children exhibiting the clinical symptoms of fucosidosis, the diagnosis was biochemically ascertained by the demonstration of a profound altpha-L-fucosidase deficiency in cultured skin fibroblasts. The non-dialysed urines of these fucosidosis patient... | [
-0.07621315866708755,
-0.014276773668825626,
-0.013659321703016758,
0.01149764470756054,
0.03649919480085373,
0.005914948880672455,
0.041735097765922546,
0.04773581773042679,
-0.046434421092271805,
-0.03548882156610489,
0.026129748672246933,
-0.12625496089458466,
-0.03251005336642265,
0.02... |
PMID:27571 | Comments on "Studies of the interaction of psychological and pharmacological determinants of smoking" by Schachter et al. | The work by Schachter and his colleagues on the psychological and pharmacological determinants of smoking is reviewed. The experiemental procedures are critically examined, and some are judged to be in violation of ethical standards for the conduct of research with human participants. Questions are raised concerning ma... | Comments on "Studies of the interaction of psychological and pharmacological determinants of smoking" by Schachter et al. The work by Schachter and his colleagues on the psychological and pharmacological determinants of smoking is reviewed. The experiemental procedures are critically examined, and some are judged to be... | [
0.02269562892615795,
0.09393264353275299,
-0.004695560317486525,
-0.035322848707437515,
0.025963537395000458,
0.02008628100156784,
0.031043769791722298,
0.009312395937740803,
-0.028816943988204002,
-0.007470464799553156,
-0.005088589619845152,
0.007266201078891754,
-0.030249454081058502,
0... |
PMID:27572 | Purification and properties of glutamate dehydrogenase from the mantle muscle of the squid, Loligo pealeii. Role of the enzyme in energy production from amino acids. | 1. The activity of glutamate dehydrogenase was measured in the tissues of the squid, Loligo pealeii. The enzyme occurs in high activity in digestive pouch, systemic heart, and all muscle tissues. 2. Glutamate dehydrogenase from mantle muscle is located intra-mitochondrially, has a molecular weight of 310,000, and is el... | Purification and properties of glutamate dehydrogenase from the mantle muscle of the squid, Loligo pealeii. Role of the enzyme in energy production from amino acids. 1. The activity of glutamate dehydrogenase was measured in the tissues of the squid, Loligo pealeii. The enzyme occurs in high activity in digestive pouch... | [
-0.03789323568344116,
-0.025445368140935898,
-0.018743736669421196,
0.012184811756014824,
0.012388922274112701,
-0.04607842490077019,
0.04856579005718231,
0.01537292916327715,
-0.028235329315066338,
-0.029628995805978775,
0.10167092084884644,
-0.12685102224349976,
0.033292438834905624,
0.0... |
PMID:27574 | Ionic blockage of the light-regulated sodium channels in isolated rod outer segments. | We have investigated, with osmotic techniques, the light-regulated Na+ channels in rod outer segments (ROS) and ROS fragments freshly isolated from the frog retina. Values of Na+ permeability (PNa) similar to those observed electrophysiologically in the retina were observed using the osmotic technique (continuous flow)... | Ionic blockage of the light-regulated sodium channels in isolated rod outer segments. We have investigated, with osmotic techniques, the light-regulated Na+ channels in rod outer segments (ROS) and ROS fragments freshly isolated from the frog retina. Values of Na+ permeability (PNa) similar to those observed electrophy... | [
-0.08606323599815369,
-0.028440210968255997,
-0.04386701062321663,
0.022176288068294525,
0.013240913860499859,
0.024017980322241783,
0.04451553523540497,
0.013375358656048775,
-0.025451986119151115,
0.03044673055410385,
-0.021251985803246498,
-0.08081039786338806,
-0.03254100680351257,
0.0... |
PMID:27575 | Nitrogen regulation of glutamine synthetase in Neurospora crassa. | A higher activity of glutamine synthetase (EC 6.3.1.2) was found in Neurospora crassa when NH4+ was limiting as nitrogen source than when glutamate was limiting. When glutamate, glutamine or NH4+ were in excess, a lower activity was found. Immunological titration and sucrose gradient sedimentation of the enzyme establi... | Nitrogen regulation of glutamine synthetase in Neurospora crassa. A higher activity of glutamine synthetase (EC 6.3.1.2) was found in Neurospora crassa when NH4+ was limiting as nitrogen source than when glutamate was limiting. When glutamate, glutamine or NH4+ were in excess, a lower activity was found. Immunological ... | [
0.019071754068136215,
-0.01698233000934124,
-0.02944873832166195,
-0.01473408192396164,
0.0007478594197891653,
0.033952467143535614,
0.03406073898077011,
-0.014582287520170212,
-0.037900447845458984,
0.02766628935933113,
0.009854082949459553,
-0.07530486583709717,
0.011739804409444332,
0.0... |
PMID:27576 | Biochemical and biophysical characterization of light and heavy density hepatitis A virus particles: evidence HAV is an RNA virus. | Heavy density HAV was also shown to be sensitive to low concentrations of RNase. The results of these biophysical and biochemical studies strongly support the notion HAV is an enterovirus. | Biochemical and biophysical characterization of light and heavy density hepatitis A virus particles: evidence HAV is an RNA virus. Heavy density HAV was also shown to be sensitive to low concentrations of RNase. The results of these biophysical and biochemical studies strongly support the notion HAV is an enterovirus. | [
-0.028726421296596527,
0.0019753514789044857,
-0.014526622369885445,
0.0014065863797441125,
0.03859417885541916,
-0.008634250611066818,
0.0936700776219368,
-0.0052686817944049835,
0.012324309907853603,
0.04009468853473663,
0.005368448328226805,
-0.1020117700099945,
-0.014049991965293884,
-... |
PMID:27577 | Behavioral rhythms in schizophrenia. | Daily behavioral observations were made for several years on 10 male schizophrenic patients and on three male patients with organic brain disorders. Analysis of these data showed strong cyclic components in the five schizophrenic patients with predominantly hebephrenic symptomatology. Period lengths noted were about 2 ... | Behavioral rhythms in schizophrenia. Daily behavioral observations were made for several years on 10 male schizophrenic patients and on three male patients with organic brain disorders. Analysis of these data showed strong cyclic components in the five schizophrenic patients with predominantly hebephrenic symptomatolog... | [
-0.038355279713869095,
0.058157991617918015,
0.008734244853258133,
0.006182563025504351,
-0.04326360300183296,
0.026060616597533226,
0.012651707045733929,
-0.017275966703891754,
0.0015426245518028736,
-0.0646502748131752,
0.015385827049612999,
0.023358702659606934,
0.00638475501909852,
0.0... |
PMID:27578 | Clinical course of adult metachromatic leukodystrophy presenting as schizophrenia. A report of two living cases in siblings. | Adult metachromatic leukodystrophy is a demyelinating disease due to an inherited lack of arylsulfatase A activity. The purpose of this paper is to present the characteristics of this disorder as they occurred chronologically in two siblings, prior to and subsequent to the appearance of gross neurological deficits. A d... | Clinical course of adult metachromatic leukodystrophy presenting as schizophrenia. A report of two living cases in siblings. Adult metachromatic leukodystrophy is a demyelinating disease due to an inherited lack of arylsulfatase A activity. The purpose of this paper is to present the characteristics of this disorder as... | [
-0.03114054538309574,
-0.03585241734981537,
-0.020200351253151894,
0.000424805999500677,
-0.028677336871623993,
0.012512478977441788,
0.0454537495970726,
0.04200785607099533,
-0.010391420684754848,
-0.00971703976392746,
0.0485210046172142,
-0.0475156344473362,
-0.006774385459721088,
0.0151... |
PMID:27579 | Neurobiology of Polyorchis. I. Function of effector systems. | The electrical correlates of activity in the effector systems responsible for swimming, crumpling and postural changes have been recorded in the anthomedusan Polyorchis penicillatus. Motor spikes (pre-swim pulses), that initiate swimming contractions, appear without delay at distant sites on the inner nerve-ring in uns... | Neurobiology of Polyorchis. I. Function of effector systems. The electrical correlates of activity in the effector systems responsible for swimming, crumpling and postural changes have been recorded in the anthomedusan Polyorchis penicillatus. Motor spikes (pre-swim pulses), that initiate swimming contractions, appear ... | [
-0.0333716943860054,
-0.06311595439910889,
0.024443866685032845,
-0.017283214256167412,
-0.05578980594873428,
0.006009929813444614,
0.059285424649715424,
0.04085501655936241,
-0.0015000486746430397,
-0.012630113400518894,
0.023641405627131462,
-0.09724298119544983,
0.012386101298034191,
0.... |
PMID:27590 | Cytochemical demonstration of adenylate and guanylate cyclases in vascular smooth muscle of circle of Willis. | The cytochemical localization of adenylate cyclase and guanylate cyclase was studied in the arteries of the circle of Willis in dogs. The reaction products of both adenylate and guanylate cyclases were similarly distributed and selectively localized predominantly adjacent to sarcoplasmic reticulum and sparsely to mitoc... | Cytochemical demonstration of adenylate and guanylate cyclases in vascular smooth muscle of circle of Willis. The cytochemical localization of adenylate cyclase and guanylate cyclase was studied in the arteries of the circle of Willis in dogs. The reaction products of both adenylate and guanylate cyclases were similarl... | [
-0.02478858083486557,
-0.05248818174004555,
-0.0249625276774168,
0.029025228694081306,
0.05622614175081253,
-0.0042620147578418255,
0.045326247811317444,
0.046548031270504,
0.01903500035405159,
-0.018841683864593506,
0.023411588743329048,
-0.07876966148614883,
-0.028849128633737564,
-0.012... |
PMID:27591 | Abnormal cellular copper metabolism in the blotchy mouse. | Defective copper metabolism was demonstrated in male mice bearing the blotchy (Moblo/y) allele at the mottled locus on the X-chromosome. Copper absorption from the gut was only 64% of that found in normal mice and hepatic copper levels were only 56% of the controls. Ceruloplasmin and heart cytochrome c oxidase activiti... | Abnormal cellular copper metabolism in the blotchy mouse. Defective copper metabolism was demonstrated in male mice bearing the blotchy (Moblo/y) allele at the mottled locus on the X-chromosome. Copper absorption from the gut was only 64% of that found in normal mice and hepatic copper levels were only 56% of the contr... | [
-0.013670114800333977,
0.0019658433739095926,
0.02917279116809368,
0.023591192439198494,
0.03977363556623459,
-0.11404004693031311,
0.04336797073483467,
0.007334722671657801,
-0.04106897488236427,
-0.0036427450831979513,
0.013833236880600452,
-0.06603675335645676,
-0.0019704808946698904,
0... |
PMID:27592 | Loss of in vitro inactivation of rat liver tyrosine aminotransferase with dietary vitamin B6 restriction. | Tyrosine aminotransferase, in the presence of 8 mM L-cysteine, is inactivated in incubated liver homogenates prepared from normal rats, but not in those from rats deprived of vitamin B6. In this study we fed rats a diet deficient in vitamin B6 to determine the length of time required for in vitro inactivating activity ... | Loss of in vitro inactivation of rat liver tyrosine aminotransferase with dietary vitamin B6 restriction. Tyrosine aminotransferase, in the presence of 8 mM L-cysteine, is inactivated in incubated liver homogenates prepared from normal rats, but not in those from rats deprived of vitamin B6. In this study we fed rats a... | [
0.0033082456793636084,
0.026283279061317444,
-0.026860453188419342,
-0.0391746461391449,
-0.030502351000905037,
0.009657713584601879,
0.0659642219543457,
0.0418441966176033,
-0.03907043859362602,
0.017111612483859062,
0.056713543832302094,
-0.07242798805236816,
0.04260104149580002,
0.02600... |
PMID:27593 | Characterization of thiamine diphosphatase in rat small intestine. | The properties of thiamine diphosphatase (TDPase) and p-nitrophenylphosphatase (p-NPPase) in rat small intestine were investigated. TDPase activity, like p-NPPase activity, was high in the mucosa and in the proximal region. Both activities were high in the membrane-associated fractions of the duodenal mucosa. Furthermo... | Characterization of thiamine diphosphatase in rat small intestine. The properties of thiamine diphosphatase (TDPase) and p-nitrophenylphosphatase (p-NPPase) in rat small intestine were investigated. TDPase activity, like p-NPPase activity, was high in the mucosa and in the proximal region. Both activities were high in ... | [
-0.03224722295999527,
0.014804098755121231,
0.0010828068479895592,
-0.0065169185400009155,
-0.004738005809485912,
-0.04362780600786209,
0.08006502687931061,
0.04068470373749733,
-0.04801667481660843,
-0.034973833709955215,
0.02227083221077919,
-0.12062191963195801,
0.01785340905189514,
-0.... |
PMID:27595 | The isolation and characterization of a trypsin inhibitor from Kintoki bean (Phaseolus vulgaris). | A trypsin inhibitor was isolated from beans of Phaseolus vulgaris, cultivar. Kintoki, and the specific activity increased 200 times as high as that of the crude extract. It was homogeneous on several electrophoreses and the molecular weight was about 13,000. The amino acid composition was characterized by high ratios o... | The isolation and characterization of a trypsin inhibitor from Kintoki bean (Phaseolus vulgaris). A trypsin inhibitor was isolated from beans of Phaseolus vulgaris, cultivar. Kintoki, and the specific activity increased 200 times as high as that of the crude extract. It was homogeneous on several electrophoreses and th... | [
-0.06020740419626236,
-0.010453581809997559,
-0.024170154705643654,
-0.014835510402917862,
0.017392540350556374,
-0.010779489763081074,
0.04796520620584488,
0.03707714006304741,
-0.06984076648950577,
-0.028294336050748825,
0.025010421872138977,
-0.06635697185993195,
0.041296545416116714,
0... |
PMID:27596 | Effects of various metabolites (sugars, carboxylic acids and alcohols) on riboflavin formation in non-growing cells of Ashbya gossypii. | The effects of various sugars and sugar derivatives on flavinogenesis were examined using non-growing cells of a high flavinogenic mold, Ashbya gossypii. Glucose, fructose and galactose were found to be the most stimulative. Glycerol and glucono-delta-lactone were less stimulative; next in order were n-propanol, n-buta... | Effects of various metabolites (sugars, carboxylic acids and alcohols) on riboflavin formation in non-growing cells of Ashbya gossypii. The effects of various sugars and sugar derivatives on flavinogenesis were examined using non-growing cells of a high flavinogenic mold, Ashbya gossypii. Glucose, fructose and galactos... | [
-0.008202643133699894,
-0.05911801755428314,
0.006220582872629166,
0.0333445705473423,
0.03968674689531326,
0.006655178964138031,
-0.022242259234189987,
0.03138875588774681,
-0.05489262193441391,
-0.022629637271165848,
0.036105651408433914,
-0.059111613780260086,
0.003365427488461137,
0.00... |
PMID:27603 | Multiple-scored tablets. Weight and content uniformity of subdivisions and distribution of active constituent within and between tablets. | Using three brands of multiple-scored levodopa tablets, B.P. (500 mg) and one brand of sulphamethoxypyridazine tablets B.P. (500 mg) the weight and content uniformity of the subdivisions has been examined. It is shown that quartering of such tablets can result in subunits which do not conform to recognized standards of... | Multiple-scored tablets. Weight and content uniformity of subdivisions and distribution of active constituent within and between tablets. Using three brands of multiple-scored levodopa tablets, B.P. (500 mg) and one brand of sulphamethoxypyridazine tablets B.P. (500 mg) the weight and content uniformity of the subdivis... | [
-0.022371603175997734,
-0.034750647842884064,
0.019791891798377037,
-0.02490822598338127,
-0.053873974829912186,
0.006015093065798283,
0.048100173473358154,
0.05580628663301468,
0.004278063308447599,
-0.018853604793548584,
-0.04317917674779892,
-0.012068791314959526,
0.02227676473557949,
0... |
PMID:27604 | The effect of repeated administration of diftalone on enzyme induction. | Plasma concentrations of diftalone have been examined in normal volunteers after a single dose (500 mg) and after 500 mg doses given twice daily for one week. An increase in post dosing urinary excretion of D-glucaric acid showed a correlation with the ratio of calculated to observed areas under the plasma concentratio... | The effect of repeated administration of diftalone on enzyme induction. Plasma concentrations of diftalone have been examined in normal volunteers after a single dose (500 mg) and after 500 mg doses given twice daily for one week. An increase in post dosing urinary excretion of D-glucaric acid showed a correlation with... | [
-0.009749272838234901,
0.03204377368092537,
0.06273984163999557,
0.03342827409505844,
-0.028758883476257324,
-0.042608581483364105,
0.015376163646578789,
0.05152410268783569,
-0.04104716330766678,
-0.11661015450954437,
0.01324752252548933,
-0.02890808694064617,
0.013695492409169674,
0.0318... |
PMID:27605 | The determination of sulphoxide in degraded phenothiazine formulations by difference spectrophotometry. | A method is described for the assay of phenothiazine sulphoxides which may be formed in phenothiazine formulations during storage under unfavourable conditions. The assay is based upon the measurement of difference absorbance of the sulphoxide solution in 0.2 M hydrochloric acid relative to an equimolar solution reduce... | The determination of sulphoxide in degraded phenothiazine formulations by difference spectrophotometry. A method is described for the assay of phenothiazine sulphoxides which may be formed in phenothiazine formulations during storage under unfavourable conditions. The assay is based upon the measurement of difference a... | [
-0.05791076645255089,
0.06264127790927887,
-0.050189144909381866,
0.013927030377089977,
0.00529417023062706,
0.03650733828544617,
0.06606326252222061,
0.025056825950741768,
-0.07063059508800507,
-0.022309675812721252,
0.013617349788546562,
-0.05163039267063141,
0.04456024616956711,
0.08860... |
PMID:27606 | Species differences in the in vitro metabolic reduction of the amphetamine metabolite, 1-phenyl-2-propanone. | Marked differences were observed, in the ability of fortified 9000 g liver homogenate supernatants from three species to reduce 1-phenyl-2-propanone to the corresponding alcohol. This metabolic keto-reduction was negligible in homogenates from the rat and extensive in the rabbit; guinea-pig liver homogenates had interm... | Species differences in the in vitro metabolic reduction of the amphetamine metabolite, 1-phenyl-2-propanone. Marked differences were observed, in the ability of fortified 9000 g liver homogenate supernatants from three species to reduce 1-phenyl-2-propanone to the corresponding alcohol. This metabolic keto-reduction wa... | [
-0.00783467199653387,
0.009339503012597561,
-0.008286228403449059,
0.03038853034377098,
0.04387488588690758,
0.046709343791007996,
0.036638710647821426,
0.05718659982085228,
-0.06983387470245361,
-0.023911749944090843,
0.030780652537941933,
-0.02884243242442608,
0.043052591383457184,
0.020... |
PMID:27607 | Effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. | The effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the gastrocnemius muscle (guinea-pigs and rats). Pyridostigmine pretreatment produced a com... | Effectiveness of pyridostigmine in reversing neuromuscular blockade produced by soman. The effects of pyridostigmine pretreatment on the neuromuscular blockade produced by soman in anaesthetized, atropinized animals have been studied on the soleus and anterior tibialis muscle (rhesus monkeys, cats and rabbits) and the ... | [
-0.040422581136226654,
0.03070743754506111,
0.03467654436826706,
0.007304265163838863,
0.016384650021791458,
-0.02728120982646942,
0.0404171347618103,
0.010512253269553185,
-0.07586321234703064,
-0.06578052788972855,
0.0014756850432604551,
-0.0030004947911947966,
-0.021357785910367966,
0.0... |
PMID:27608 | The relationship between cholinesterase inhibition in the chick biventer cervicis muscle and its sensitivity to exogenous acetylcholine. | The effect of physostigmine has been studied on cholinesterase in homogenates of chick biventer cervicis muscles and on the contractile responses of the intact muscles to acetylcholine and carbachol. The concentration of physostigmine required to produce the maximum increase in sensitivity to acetylcholine almost compl... | The relationship between cholinesterase inhibition in the chick biventer cervicis muscle and its sensitivity to exogenous acetylcholine. The effect of physostigmine has been studied on cholinesterase in homogenates of chick biventer cervicis muscles and on the contractile responses of the intact muscles to acetylcholin... | [
-0.05383310839533806,
-0.0103286849334836,
-0.004005413968116045,
0.03578081727027893,
-0.028742654249072075,
-0.01904739812016487,
0.0530286580324173,
0.05100633576512337,
0.009296512231230736,
-0.05717894434928894,
-0.026939842849969864,
-0.04567014425992966,
0.004749063402414322,
0.0256... |
PMID:27609 | Pharmacological study of chicken airway smooth muscle. | Isolated chicken bronchus contracts to carbachol, PGF2alpha, histamine, 5-HT, bradykinin and phenylephrine. The bronchial strips from the horse plasma sensitized domestic fowl contracted to specific sensitizing antigen in vitro (Schultz-Dale anaphylactic reaction) and were 5 to 10 fold more reactive to PGF2alpha, hista... | Pharmacological study of chicken airway smooth muscle. Isolated chicken bronchus contracts to carbachol, PGF2alpha, histamine, 5-HT, bradykinin and phenylephrine. The bronchial strips from the horse plasma sensitized domestic fowl contracted to specific sensitizing antigen in vitro (Schultz-Dale anaphylactic reaction) ... | [
-0.04628022015094757,
-0.05403563752770424,
-0.02537495270371437,
0.021895714104175568,
-0.006395338103175163,
-0.007402191869914532,
0.09550957381725311,
0.06011870875954628,
-0.04399355873465538,
-0.043578989803791046,
-0.017626887187361717,
-0.07265560328960419,
-0.024578450247645378,
0... |
PMID:27610 | The evaluation of cardiovascular drugs in the anaesthetized, unrestrained rat. | A method is reported which allows continuous long-term drug administration and simultaneous blood pressure measurement in the unanaesthetized unrestrained rat. The external jugular vein and abdominal aorta were cannulated and the opposite ends of the cannulae were passed subcutaneously and exteriorized at the back of t... | The evaluation of cardiovascular drugs in the anaesthetized, unrestrained rat. A method is reported which allows continuous long-term drug administration and simultaneous blood pressure measurement in the unanaesthetized unrestrained rat. The external jugular vein and abdominal aorta were cannulated and the opposite en... | [
-0.047123026102781296,
0.002863904694095254,
0.014562783762812614,
0.043274249881505966,
-0.003679536748677492,
0.0040220036171376705,
0.05965223163366318,
0.02099933661520481,
-0.04294984042644501,
-0.05546647682785988,
-0.02500678412616253,
-0.0007995333871804178,
0.026675278320908546,
0... |
PMID:27624 | Physicochemical properties of amphoteric beta-lactam antibiotics I: Stability, solubility, and dissolution behavior of amino penicillins as a function of pH. | The degradation rate, solubility, and dissolution rate of amino penicillins, amoxicillin, ampicillin, epicillin, and cyclacillin, were determined quantitatively as a function of pH. In the pH range studied, 0.30-10.50, the degradation of amoxicillin and epicillin followed pseudo-first-order kinetics to give the same ty... | Physicochemical properties of amphoteric beta-lactam antibiotics I: Stability, solubility, and dissolution behavior of amino penicillins as a function of pH. The degradation rate, solubility, and dissolution rate of amino penicillins, amoxicillin, ampicillin, epicillin, and cyclacillin, were determined quantitatively a... | [
-0.074625663459301,
-0.033047307282686234,
0.013931171037256718,
-0.001273114001378417,
0.036306824535131454,
-0.006833321414887905,
0.04635997489094734,
0.039731886237859726,
-0.05971302092075348,
-0.030020276084542274,
0.0010317255510017276,
-0.05211518332362175,
0.03511911258101463,
0.0... |
PMID:27625 | Mechanism of adsorption of clindamycin and tetracycline by montmorillonite. | IR and X-ray analyses of the interaction of clindamycin with montmorillonite indicate that clindamycin is adsorbed by a cation-exchange mechanism under pH conditions favoring the cationic form of the drug and by physical adsorption when the unionized drug is present. This physical adsorption is relatively weak since th... | Mechanism of adsorption of clindamycin and tetracycline by montmorillonite. IR and X-ray analyses of the interaction of clindamycin with montmorillonite indicate that clindamycin is adsorbed by a cation-exchange mechanism under pH conditions favoring the cationic form of the drug and by physical adsorption when the uni... | [
-0.05835258215665817,
0.0035653458908200264,
-0.010134502314031124,
0.061022792011499405,
0.002542660804465413,
-0.06676076352596283,
0.025775816291570663,
0.009852814488112926,
-0.04233645275235176,
-0.027040397748351097,
0.05476698651909828,
-0.05704040825366974,
0.04467346891760826,
0.0... |
PMID:27627 | Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation. | The kinetics of the thermal degradation of promethazine in an acidic medium under various conditions were investigated. The degradation of promethazine and the formation of some degradation products were studied under aerobic and anaerobic conditions. The influence of pH, metal ions such as copper(II) and iron (III), a... | Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation. The kinetics of the thermal degradation of promethazine in an acidic medium under various conditions were investigated. The degradation of promethazine and the formation of some degradation products... | [
-0.05315045267343521,
0.08094075322151184,
-0.02799322083592415,
0.04782652109861374,
0.03536677360534668,
-0.0261379387229681,
0.0120256831869483,
-0.005694766528904438,
-0.04580063000321388,
-0.006662344094365835,
0.027317380532622337,
-0.006820462178438902,
0.07776887714862823,
0.079594... |
PMID:27628 | Nature of amorphous aluminum hydroxycarbonate. | The titration of sodium carbonate with aluminum nitrate is shown to produce amorphous aluminum hydroxycarbonate. This compound is not stoichiometric, although the maximum carbonate to aluminum ratio appears to be 0.5. The pH conditions for achieving the maximum carbonate content are concentration dependent. A model for... | Nature of amorphous aluminum hydroxycarbonate. The titration of sodium carbonate with aluminum nitrate is shown to produce amorphous aluminum hydroxycarbonate. This compound is not stoichiometric, although the maximum carbonate to aluminum ratio appears to be 0.5. The pH conditions for achieving the maximum carbonate c... | [
-0.07406175136566162,
0.012726640328764915,
-0.01925838179886341,
0.006677991710603237,
-0.030122030526399612,
-0.009507691487669945,
0.013332216069102287,
-0.015610736794769764,
-0.06736519932746887,
0.014569660648703575,
0.035845715552568436,
-0.05878317356109619,
-0.034281983971595764,
... |
PMID:27629 | Interference in assays for hydralazine in humans by a major plasma metabolite, hydralazine pyruvic acid hydrazone. | The present study showed that published spectrophotometric and GLC methods for hydralazine in plasma do not distinguish between the drug and a major plasma metabolite, hydralazine pyruvic acid hydrazone. These methods involve the acid treatment of the sample, which hydrolyzes that hydrazone back to hydralazine. A speci... | Interference in assays for hydralazine in humans by a major plasma metabolite, hydralazine pyruvic acid hydrazone. The present study showed that published spectrophotometric and GLC methods for hydralazine in plasma do not distinguish between the drug and a major plasma metabolite, hydralazine pyruvic acid hydrazone. T... | [
-0.03384925052523613,
0.04283588007092476,
-0.025580544024705887,
0.06372669339179993,
0.06937318295240402,
-0.0029733856208622456,
0.03148575872182846,
0.05311163514852524,
-0.08943072706460953,
-0.02966485358774662,
0.046930942684412,
-0.011578246019780636,
0.02461208961904049,
0.0156203... |
PMID:27630 | Automated potentiometric procedure for studying dissolution kinetics acidic drugs under sink conditions. | An automated potentiometric procedure was used for studying in vitro dissolution kinetics of acidic drugs. Theoretical considerations indicated that the pH-stat method could be used to establish approximate sink conditions or, possibly, a perfect sink. Data obtained from dissolution studies using the pH-stat method wer... | Automated potentiometric procedure for studying dissolution kinetics acidic drugs under sink conditions. An automated potentiometric procedure was used for studying in vitro dissolution kinetics of acidic drugs. Theoretical considerations indicated that the pH-stat method could be used to establish approximate sink con... | [
-0.018345819786190987,
0.013325909152626991,
0.015530171804130077,
0.004894712939858437,
0.0024817779194563627,
-0.05005044862627983,
0.027230309322476387,
0.012161613442003727,
-0.02850845269858837,
-0.0752234160900116,
-0.003677071537822485,
-0.05500936135649681,
0.03773616626858711,
0.0... |
PMID:27633 | A controlled trial of antiemetics in abortion by PGF2alpha and laminaria. | Women undergoing abortion by intraamniotic prostaglandin F2alpha were randomized to receive either prochlorperazine edisylate 10mg, hydroxyzine hydrochloride 100mg, or a placebo every four hours by intramuscular injection in a double-blind fashion. Vomiting was significantly more frequent in the placebo-treated group [... | A controlled trial of antiemetics in abortion by PGF2alpha and laminaria. Women undergoing abortion by intraamniotic prostaglandin F2alpha were randomized to receive either prochlorperazine edisylate 10mg, hydroxyzine hydrochloride 100mg, or a placebo every four hours by intramuscular injection in a double-blind fashio... | [
-0.03255803510546684,
0.02059035189449787,
-0.0660085529088974,
0.01796230487525463,
0.013401022180914879,
0.016824858263134956,
0.060271091759204865,
0.04259118437767029,
0.0053474572487175465,
-0.017509033903479576,
0.012293456122279167,
-0.004776350688189268,
-0.0060050878673791885,
0.0... |
PMID:27634 | Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles. | Several new alpha-amino-alpha-phenyl-o-tolytriazoles and -imidazoles have been prepared in one step by means of a novel reductive rearrangement of the corresponding benzodiazepines with hydrazine hydrate. These new triazoles were found to have moderate sedative and muscle relaxing activity in mice (i.e., these compound... | Novel anxiolytic agents derived from alpha-amino-alpha-phenyl-o-tolyl-4H-triazoles and -imidazoles. Several new alpha-amino-alpha-phenyl-o-tolytriazoles and -imidazoles have been prepared in one step by means of a novel reductive rearrangement of the corresponding benzodiazepines with hydrazine hydrate. These new triaz... | [
-0.07295191287994385,
-0.0240478552877903,
0.00626769196242094,
0.03916041925549507,
0.03518494591116905,
-0.0056302365846931934,
0.004883528687059879,
0.03730446472764015,
-0.03217855840921402,
-0.062491197139024734,
-0.0003154562436975539,
-0.018366467207670212,
-0.0003595143207348883,
0... |
PMID:27635 | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. | The synthesis of N-hydroxyacetaminophen (N-acetyl-N-hydroxy-p-aminophenol, 4), a postulated toxic metabolite of acetaminophen (N-acetyl-p-aminophenol, 3), and its phenolic sulfate conjugate (potassium N-acetyl-N-hydroxy-p-aminophenyl sulfate) (13) is described. Potassium p-nitrophenyl sulfate was reduced to the hydroxy... | Synthesis of N-hydroxyacetaminophen, a postulated toxic metabolite of acetaminophen, and its phenolic sulfate conjugate. The synthesis of N-hydroxyacetaminophen (N-acetyl-N-hydroxy-p-aminophenol, 4), a postulated toxic metabolite of acetaminophen (N-acetyl-p-aminophenol, 3), and its phenolic sulfate conjugate (potassiu... | [
-0.06509340554475784,
-0.04562073200941086,
-0.08765581250190735,
0.00529963243752718,
0.025878190994262695,
-0.012300282716751099,
0.019151421263813972,
-0.007780896499752998,
-0.042116928845644,
-0.005849678535014391,
0.043749839067459106,
-0.07490351796150208,
0.028218261897563934,
-0.0... |
PMID:27637 | Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues. | The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The animal models were predictive of neuroleptic activity as well as side effects commonly associated with neuroleptic therapy. The results indicate that the 3-substituent plays a critical role ... | Neuroleptics related to butaclamol. Synthesis and some psychopharmacological effects of a series of 3-aryl analogues. The synthesis and some pharmacological effects of 16 3-aryl analogues of butaclamol, a new antipsychotic drug, are described. The animal models were predictive of neuroleptic activity as well as side ef... | [
-0.041438665241003036,
-0.05282648652791977,
-0.020194169133901596,
0.02548951841890812,
0.049888260662555695,
0.016719795763492584,
0.004066061228513718,
-0.0027531094383448362,
-0.024511324241757393,
-0.01821734756231308,
0.01306406781077385,
-0.04468962550163269,
-0.0014336132444441319,
... |
PMID:27638 | 5-Carboxamido-4-amino-3-isoxazolidone, and asparagine analogue. | trans-Aziridine-2,3-dicarboxylic ester was used to prepare the required beta-chlorohydroxamic acid used in the synthesis of the title compound. The trans configuration of the asparagine analogue was established by hydrogenolysis to erythro-beta-hydroxyasparagine amide. Neither the title compound nor the intermediate az... | 5-Carboxamido-4-amino-3-isoxazolidone, and asparagine analogue. trans-Aziridine-2,3-dicarboxylic ester was used to prepare the required beta-chlorohydroxamic acid used in the synthesis of the title compound. The trans configuration of the asparagine analogue was established by hydrogenolysis to erythro-beta-hydroxyaspa... | [
-0.05588233470916748,
0.01483522541821003,
-0.009443440474569798,
0.04273371770977974,
-0.021632231771945953,
0.022457994520664215,
0.05263591557741165,
0.055735595524311066,
-0.10666661709547043,
0.06314105540513992,
0.016216779127717018,
-0.020414603874087334,
0.008147697895765305,
0.059... |
PMID:27639 | Autosomal recessive postaxial polydactyly type A in a Sicilian family. | Postaxial polydactyly type A was present in several members of a Sicilian family. The anomaly was probably transmitted as an autosomal recessive character. Two polydactylous subjects were also beta-thalassaemia carriers, but a linkage between the two mutant genes could be excluded. Two patients with hexadactyly had a f... | Autosomal recessive postaxial polydactyly type A in a Sicilian family. Postaxial polydactyly type A was present in several members of a Sicilian family. The anomaly was probably transmitted as an autosomal recessive character. Two polydactylous subjects were also beta-thalassaemia carriers, but a linkage between the tw... | [
-0.03378291428089142,
0.038029514253139496,
0.0398532897233963,
-0.0025071133859455585,
-0.05350283533334732,
0.020609023049473763,
0.010780498385429382,
0.045412853360176086,
-0.04707620292901993,
-0.0226906631141901,
0.08691424131393433,
-0.07163465023040771,
-0.022271087393164635,
-0.00... |
PMID:27641 | The influence of various cations on the catalytic properties of clays. | Polymerization of alanine adenylate in the presence of various clays in their Na form gave increasing degrees of polymerization in the following order: montmorillonite less than nontronite less than hectorite. With montmorillonite, presaturated with different cations the order was: Mg less Ca less than Fe less than Al ... | The influence of various cations on the catalytic properties of clays. Polymerization of alanine adenylate in the presence of various clays in their Na form gave increasing degrees of polymerization in the following order: montmorillonite less than nontronite less than hectorite. With montmorillonite, presaturated with... | [
-0.043424129486083984,
-0.006653389427810907,
-0.009003874845802784,
0.023326076567173004,
-0.023043764755129814,
0.014088019728660583,
0.03262462094426155,
-0.0054539404809474945,
-0.04520628973841667,
-0.0012346752919256687,
0.01678541861474514,
-0.041617441922426224,
-0.013087675906717777... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.