id stringlengths 7 10 | title stringlengths 8 354 | content stringlengths 91 4.1k | contents stringlengths 164 4.24k | embedding listlengths 384 384 |
|---|---|---|---|---|
PMID:27642 | Biotin. Its place in evolution. | In the previous article we try to give an explanation for the success of models of enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorgan... | Biotin. Its place in evolution. In the previous article we try to give an explanation for the success of models of enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally... | [
-0.07743993401527405,
0.027468115091323853,
-0.021693246439099312,
0.01714293099939823,
0.024182545021176338,
-0.011602798476815224,
0.03726433217525482,
0.051627691835165024,
-0.018423106521368027,
-0.03852942958474159,
0.05108039826154709,
-0.07835087925195694,
-0.01981491409242153,
-0.0... |
PMID:27644 | Covalent coupling of calf brain prolidase. | Calf brain prolidase covalently bound to CNBr-Sepharose 4B, retained about 32% of the activity of the uncoupled enzyme. The free enzyme showed slightly greater stability than the bound preparation when stored at 20 degrees C or at 0 degrees C. However, in either case the free and bound enzymes were more stable at the l... | Covalent coupling of calf brain prolidase. Calf brain prolidase covalently bound to CNBr-Sepharose 4B, retained about 32% of the activity of the uncoupled enzyme. The free enzyme showed slightly greater stability than the bound preparation when stored at 20 degrees C or at 0 degrees C. However, in either case the free ... | [
-0.0955410823225975,
-0.006243201903998852,
-0.030197512358427048,
0.015030165202915668,
0.0022042025811970234,
-0.021904148161411285,
0.053511518985033035,
-0.006294205319136381,
-0.031035345047712326,
-0.021348826587200165,
-0.0005039729876443744,
-0.03633730486035347,
-0.00893841963261365... |
PMID:27645 | Characterization of an alkaline protease associated with a granulosis virus of Plodia interpunctella. | An alkaline protease was found to be associated with the granulosis virus of the Indian meal moth. Plodia interpunctella. The protease was located within the protein matrix of the occluded virus and hydrolyzed the major constituent of this matrix, a 28,000-dalton protein (granulin), to a mixture of polypeptides ranging... | Characterization of an alkaline protease associated with a granulosis virus of Plodia interpunctella. An alkaline protease was found to be associated with the granulosis virus of the Indian meal moth. Plodia interpunctella. The protease was located within the protein matrix of the occluded virus and hydrolyzed the majo... | [
-0.04855813831090927,
-0.029499700292944908,
-0.053120486438274384,
0.017113955691456795,
0.04114057123661041,
-0.0893777385354042,
0.06034896895289421,
0.04855761677026749,
-0.01109237875789404,
0.02692139893770218,
0.010176971554756165,
-0.07863285392522812,
-0.0045419782400131226,
0.029... |
PMID:27646 | The urologic manifestations of XO/XY mosaicism. | The mosaic karyotype XO/XY is expressed by a spectrum of genital phenotypes, ranging from normal male through ambiguous genitalia to normal female. The urologist may see some of these patients because of the following clinical presentations: 1) ambiguous genitalia with a chromatin-negative buccal smear, 2) hypospadias ... | The urologic manifestations of XO/XY mosaicism. The mosaic karyotype XO/XY is expressed by a spectrum of genital phenotypes, ranging from normal male through ambiguous genitalia to normal female. The urologist may see some of these patients because of the following clinical presentations: 1) ambiguous genitalia with a ... | [
0.03883291408419609,
0.023997889831662178,
0.08276768773794174,
0.04954768344759941,
-0.058550719171762466,
0.016861721873283386,
0.02294260635972023,
0.052347470074892044,
-0.006101962178945541,
0.05256884545087814,
0.020608210936188698,
-0.032846324145793915,
0.05679120868444443,
0.04093... |
PMID:27648 | Bilateral trifid ureters associated with fused kidney, ureterovesical stenosis, left cryptorchidism and angioma of the bladder. | The first case of bilateral trifid ureters associated with fused kidney, ureterovesical stenosis, a left undescended testicle and angioma of the bladder is reported. Bilateral ureteroneocystostomy and left orchiopexy were done. The patient is well 3 months postoperatively with no urinary tract infection and stable rena... | Bilateral trifid ureters associated with fused kidney, ureterovesical stenosis, left cryptorchidism and angioma of the bladder. The first case of bilateral trifid ureters associated with fused kidney, ureterovesical stenosis, a left undescended testicle and angioma of the bladder is reported. Bilateral ureteroneocystos... | [
0.023991309106349945,
-0.06065068393945694,
0.025054313242435455,
0.053112685680389404,
-0.022143185138702393,
-0.01681598834693432,
0.054917946457862854,
0.033638544380664825,
-0.03360843285918236,
-0.001139981672167778,
0.041669756174087524,
-0.07799269258975983,
0.07640066742897034,
-0.... |
PMID:27659 | [The determination of a small amount of chlorine in the atmosphere by using 4-nitroaniline (author's transl)]. | The determination of small amount of chlorine in the atmosphere is carried on ordinarily by omicron-toluidine method at present. However, this method is not recommended because the issued colour is unstable and omicron-toluidine itself belongs in the first group member of the Ordinance on Prevention of Particular Chemi... | [The determination of a small amount of chlorine in the atmosphere by using 4-nitroaniline (author's transl)]. The determination of small amount of chlorine in the atmosphere is carried on ordinarily by omicron-toluidine method at present. However, this method is not recommended because the issued colour is unstable an... | [
-0.05679481476545334,
0.025265617296099663,
0.008319830521941185,
0.008920853957533836,
0.05871516466140747,
0.025015363469719887,
0.06387107074260712,
0.0057348026894032955,
-0.060998134315013885,
0.0002144746686099097,
-0.011742273345589638,
-0.06499426811933517,
-0.008388401940464973,
0... |
PMID:27664 | [Effect of adrenergic beta receptor blockaders on bronchial patency in ischemic heart disease]. | The effect of beta-adrenergic blocking agents inderal, trazicor, visken, benzoral and aptin on the bronchial patency was studied by means of four ventilation indices in 85 patients, 62 of whome had various diseases of the lungs; 44 of these patients had bronchial obstruction. It was established that all beta-blocking a... | [Effect of adrenergic beta receptor blockaders on bronchial patency in ischemic heart disease]. The effect of beta-adrenergic blocking agents inderal, trazicor, visken, benzoral and aptin on the bronchial patency was studied by means of four ventilation indices in 85 patients, 62 of whome had various diseases of the lu... | [
-0.04901152849197388,
-0.0020511827897280455,
-0.02578430250287056,
0.01694982498884201,
0.01288587786257267,
0.00982183963060379,
0.041900359094142914,
-0.004534629173576832,
-0.03545790910720825,
-0.04547574743628502,
-0.04340512678027153,
-0.030560797080397606,
0.004444333259016275,
0.0... |
PMID:27665 | [Transient myopia with angle closure glaucoma. Case report and biometric findings (author's transl)]. | A 36-year-old man suffered from diarrhoea for some weeks and was treated with Salazosulphapyridie and Fluocortulon when he developed a transient myopia combined with an angle closure glaucoma. The refraction of his mild hyperopic eyes (+0,5 dpt) changed to -5,5 dpt and the intraocular pressure increased to 40 mm Hg in ... | [Transient myopia with angle closure glaucoma. Case report and biometric findings (author's transl)]. A 36-year-old man suffered from diarrhoea for some weeks and was treated with Salazosulphapyridie and Fluocortulon when he developed a transient myopia combined with an angle closure glaucoma. The refraction of his mil... | [
0.01653425768017769,
0.0014285814249888062,
0.046036094427108765,
0.03510620445013046,
0.0032224850729107857,
-0.029472315683960915,
0.045378267765045166,
0.016242146492004395,
-0.057352159172296524,
-0.07232582569122314,
-0.02628144808113575,
-0.038813844323158264,
-0.03218356892466545,
-... |
PMID:27691 | Semisynthetic derivatives of pyrrolizidine alkaloids of pharmacodynamic importance: a review. | Pyrrolizidine alkaloids occur in more than 40 genera. Among these are two important genera, Senecio and Crotalaria, which have been responsible for heavy losses of livestock and poisoning in man due to their hepatotoxicity. Pyrrolizidine alkaloids are also reported to possess a number of other biological activities. At... | Semisynthetic derivatives of pyrrolizidine alkaloids of pharmacodynamic importance: a review. Pyrrolizidine alkaloids occur in more than 40 genera. Among these are two important genera, Senecio and Crotalaria, which have been responsible for heavy losses of livestock and poisoning in man due to their hepatotoxicity. Py... | [
0.00033303798409178853,
0.02013660967350006,
0.04673588275909424,
0.0050927503034472466,
-0.07290905714035034,
0.007902177982032299,
-0.0025709387846291065,
0.00952499732375145,
-0.06916532665491104,
0.0009033904643729329,
-0.01107206754386425,
-0.025567159056663513,
-0.021473001688718796,
... |
PMID:27696 | An adverse effect of insulin on the oxygen-release capacity of red blood cells in nonacidotic diabetics. | Oxyhemoglobin dissociation curves (ODC) were performed on blood from newly diagnosed, nonketotic diabetics prior to and following initial insulin treatment and from ambulatory juvenile diabetics before and after their usual morning insulin. In 10 newly discovered diabetics the average P50 at in vivo pH was normal prior... | An adverse effect of insulin on the oxygen-release capacity of red blood cells in nonacidotic diabetics. Oxyhemoglobin dissociation curves (ODC) were performed on blood from newly diagnosed, nonketotic diabetics prior to and following initial insulin treatment and from ambulatory juvenile diabetics before and after the... | [
-0.0645003691315651,
0.022065619006752968,
0.019518228247761726,
-0.012602327391505241,
0.005975241307169199,
-0.022664044052362442,
0.03876503184437752,
0.03617832437157631,
-0.035639747977256775,
-0.003316523740068078,
0.04735143110156059,
-0.06869875639677048,
-0.01854100450873375,
0.05... |
PMID:27701 | Kinetic properties of pyruvate kinase of Neurospora crassa at physiological pH. | The kinetic properties of pyruvate kinase (EC 2.7.1.40) extracted from the mycelia of Neurospora crassa were examined at physiological pH to determine the role of the enzyme in the regulation of glycolysis. The velocity curve with the substrates, phosphoenolpyruvate and adenosine diphosphate, are hyperbolic. The effect... | Kinetic properties of pyruvate kinase of Neurospora crassa at physiological pH. The kinetic properties of pyruvate kinase (EC 2.7.1.40) extracted from the mycelia of Neurospora crassa were examined at physiological pH to determine the role of the enzyme in the regulation of glycolysis. The velocity curve with the subst... | [
-0.055380113422870636,
0.02943442575633526,
0.002057126024737954,
0.031158240512013435,
0.0015850521158427,
-0.026093291118741035,
0.047481030225753784,
-0.0011698310263454914,
-0.08136145770549774,
0.016139594838023186,
0.03915249928832054,
-0.08563714474439621,
-0.009503371082246304,
0.0... |
PMID:27702 | The influence of pH on the growth rate and viability of neutrophilic and acidophilic streptomycetes. | The influence of pH on the specific growth rates of two acidophilic and two neutrophilic soil streptomycetes was studied. The acidophiles had maximum growth rates over a broad range from pH 4.5 to 5.5, while the neutrophiles had clearly defined optima at pH 7.0. Mycelium of neutrophiles was less tolerant of acidity tha... | The influence of pH on the growth rate and viability of neutrophilic and acidophilic streptomycetes. The influence of pH on the specific growth rates of two acidophilic and two neutrophilic soil streptomycetes was studied. The acidophiles had maximum growth rates over a broad range from pH 4.5 to 5.5, while the neutrop... | [
-0.05284131318330765,
-0.048701755702495575,
-0.015506128780543804,
0.024640247225761414,
0.013790558092296124,
-0.03804559260606766,
0.005065724719315767,
0.036101847887039185,
-0.055581916123628616,
0.030328361317515373,
0.010266064666211605,
-0.06297216564416885,
0.02962515316903591,
0.... |
PMID:27703 | Cell wall autolysis in log phase cells of Micrococcus lysodeikticus (luteus). | Log phase cells of Micrococcus lysodeikticus (luteus) IFO 3333 autolyzed when incubated at 37 C in 0.01 M sodium-phosphate buffer pH 7.5. The enzyme involved in the autolysis was recovered mainly in an aqueous phase from cytoplasmic membranes and cytoplasmic materials treated with n-butanol, and proved to be an N-acety... | Cell wall autolysis in log phase cells of Micrococcus lysodeikticus (luteus). Log phase cells of Micrococcus lysodeikticus (luteus) IFO 3333 autolyzed when incubated at 37 C in 0.01 M sodium-phosphate buffer pH 7.5. The enzyme involved in the autolysis was recovered mainly in an aqueous phase from cytoplasmic membranes... | [
-0.058807507157325745,
0.001202689134515822,
0.01109921745955944,
-0.02247999981045723,
0.02550058253109455,
-0.042411260306835175,
0.004555712919682264,
-0.004772279877215624,
-0.014717692509293556,
-0.04909420385956764,
0.06290064752101898,
-0.06062370538711548,
-0.015534928999841213,
0.... |
PMID:27704 | A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. | A method for quantitative extraction of extravasated dye from the skin was studied in guinea pigs and rats. A simple method with a low cost and good recovery was established as follows; A piece of the skin containing extravasated dye was soaked overnight in a stoppered glass tube containing 1 ml of 1 N KOH at 37 C. The... | A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. A method for quantitative extraction of extravasated dye from the skin was studied in guinea pigs and rats. A simple method with a low cost and good recovery was esta... | [
-0.06032226234674454,
0.020255237817764282,
-0.0002531945356167853,
0.04312705621123314,
0.06911568343639374,
-0.025416025891900063,
0.05079170688986778,
0.009614961221814156,
-0.05585116520524025,
-0.029096292331814766,
-0.006468398962169886,
-0.06396105885505676,
0.00454853055998683,
0.0... |
PMID:27709 | [Provocative gamma GT test in chronic pancreatitis? (author's transl)]. | The increase of serum gamma-GT after hormonal stimulation has been reported as a new provocative test in the diagnosis of chronic pancreatitis. The test was suggested to be more sensitive than the serum amylase provocation test. In a clinical study of both tests in 83 consecutive patients the unsensitivity and the high... | [Provocative gamma GT test in chronic pancreatitis? (author's transl)]. The increase of serum gamma-GT after hormonal stimulation has been reported as a new provocative test in the diagnosis of chronic pancreatitis. The test was suggested to be more sensitive than the serum amylase provocation test. In a clinical study... | [
0.0015073829563334584,
0.05368649214506149,
0.03110887110233307,
0.05393495410680771,
-0.003514167619869113,
0.012287014164030552,
0.08183297514915466,
0.07731427997350693,
-0.04244617000222206,
-0.04921206831932068,
-0.039748553186655045,
-0.06553076952695847,
-0.045841116458177567,
0.073... |
PMID:27705 | [Acetic acid, a catabolite repressor of cholinesterase synthesis by an Arthrobacter simplex culture]. | Acetic acid was found to repress cholinesterase synthesis in the cells of Arthrobacter simplex var. cholinesterasus even at very low concentrations (0.1%). The repression is very stable. It is not eliminated by glucose or an organic acid of the Krebs cycle being added to the medium with acetic acid. The combination of ... | [Acetic acid, a catabolite repressor of cholinesterase synthesis by an Arthrobacter simplex culture]. Acetic acid was found to repress cholinesterase synthesis in the cells of Arthrobacter simplex var. cholinesterasus even at very low concentrations (0.1%). The repression is very stable. It is not eliminated by glucose... | [
-0.019624730572104454,
0.05831978842616081,
-0.04725165665149689,
0.039698921144008636,
-0.008268721401691437,
-0.020645303651690483,
0.00994114764034748,
0.047580476850271225,
-0.05866276100277901,
-0.013210777193307877,
0.0012791580520570278,
-0.07979024201631546,
0.08029340207576752,
-0... |
PMID:27710 | [Disorder of porphyrin metabolism in thallium intoxication (author's transl)]. | A 19-year old male ingested in suicidal attempt 750 mg of thallium. He developed the characteristic symptoms of thallium intoxication. During the acute phase the urinary excretion of porphyrins and porphyrin precursors was largely increased. The percentage distribution of the individual metabolites of heme synthesis re... | [Disorder of porphyrin metabolism in thallium intoxication (author's transl)]. A 19-year old male ingested in suicidal attempt 750 mg of thallium. He developed the characteristic symptoms of thallium intoxication. During the acute phase the urinary excretion of porphyrins and porphyrin precursors was largely increased.... | [
-0.08075037598609924,
0.023590171709656715,
0.012596028856933117,
0.04990963637828827,
0.04468359798192978,
-0.010402676649391651,
0.06521566212177277,
0.05017582327127457,
-0.059205491095781326,
-0.0007133434410206974,
-0.0005104515003040433,
-0.08194337785243988,
0.003252403810620308,
0.... |
PMID:27706 | [Effect of pH values of the medium unfavorable for growth on the physiological, morphological and cytological characteristics of a chemostat culture of Candida utilis]. | The effect of growth inhibiting values of pH of the medium (pH 2.3 and 7.8) on physiological, morphological and cytological characteristics was studied with the chemostat culture of Candida utilis. Changes in the pH of the medium were accompanied with a decrease in the economic coefficient of the yeast cells, an increa... | [Effect of pH values of the medium unfavorable for growth on the physiological, morphological and cytological characteristics of a chemostat culture of Candida utilis]. The effect of growth inhibiting values of pH of the medium (pH 2.3 and 7.8) on physiological, morphological and cytological characteristics was studied... | [
-0.0012172876158729196,
-0.0004120919038541615,
0.011060308665037155,
0.040280312299728394,
0.03817300125956535,
-0.008411793038249016,
0.02802947163581848,
0.05211575701832771,
-0.005304156336933374,
0.008364446461200714,
0.02479061856865883,
-0.06669623404741287,
0.04015126824378967,
0.0... |
PMID:27707 | [Action of copper ions and of unfavorable medium pH values on protein and RNA synthesis by Candida utilis cells]. | The effect of copper ions and unfavourable pH values of the medium on the incorporation of labelled precursors of protein and RNA was studied in Candida utilis. Specific inhibition of protein synthesis by copper ions and alkaline conditions was found. No specific inhibition of protein or RNA was detected at low pH valu... | [Action of copper ions and of unfavorable medium pH values on protein and RNA synthesis by Candida utilis cells]. The effect of copper ions and unfavourable pH values of the medium on the incorporation of labelled precursors of protein and RNA was studied in Candida utilis. Specific inhibition of protein synthesis by c... | [
-0.028833700343966484,
-0.016125425696372986,
0.009878542274236679,
0.032685138285160065,
0.024643324315547943,
-0.03309711441397667,
0.05362293869256973,
0.03669191896915436,
-0.02600516751408577,
0.039990950375795364,
-0.0102979252114892,
-0.0776747614145279,
0.020466582849621773,
0.0486... |
PMID:27713 | Enlarged acid-base and blood gas calculations by electronical data computing in the blood gas laboratory. | A rapid anaysis of parameters of the acid-base equilibrium and blood gases during open heart surgery and emergency therapy is absolutely necessary. Computing of the several parameters of the acid-base status by slide rules or nomograms is time consuming and can be shortened by computer applications. The central blood g... | Enlarged acid-base and blood gas calculations by electronical data computing in the blood gas laboratory. A rapid anaysis of parameters of the acid-base equilibrium and blood gases during open heart surgery and emergency therapy is absolutely necessary. Computing of the several parameters of the acid-base status by sli... | [
-0.04735615476965904,
0.03508169203996658,
0.04470105841755867,
0.02778838947415352,
-0.024467792361974716,
0.0012092865072190762,
0.042830925434827805,
0.06200264394283295,
-0.02889067493379116,
-0.014647671021521091,
0.009328950196504593,
-0.05585585534572601,
-0.005550924688577652,
0.06... |
PMID:27716 | Characterisation of ribosomal proteins from HeLa and Krebs II mouse ascites tumor cells by different two-dimensional polyacrylamide gel electrophoresis techniques. | Electrophoresis of ribosomal proteins according to Kaltschmidt and Wittmann, 1970a, b (pH 8.6/pH 4.5 urea system) yielded 29 proteins for the small subunits and 35 and 37 proteins for the large subunits of Krebs II ascites and HeLa ribosomes, respectively. Analysis of the proteins according to a modified technique by M... | Characterisation of ribosomal proteins from HeLa and Krebs II mouse ascites tumor cells by different two-dimensional polyacrylamide gel electrophoresis techniques. Electrophoresis of ribosomal proteins according to Kaltschmidt and Wittmann, 1970a, b (pH 8.6/pH 4.5 urea system) yielded 29 proteins for the small subunits... | [
-0.10745950788259506,
-0.06285148113965988,
-0.03274068236351013,
-0.010621735826134682,
0.00036294336314313114,
0.019197631627321243,
0.03759016469120979,
0.015148838050663471,
-0.026313040405511856,
0.018210500478744507,
0.03146451339125633,
-0.08133950084447861,
0.001898690010420978,
-0... |
PMID:27718 | Fidelity of conjugation in Saccharomyces cerevisiae. | An efficient method for the production of synchronous zygotes in Saccharomyces cerevisiae is described. Cells were synchronised under defined conditions in either an a, alpha mixed culture or by incubation of each mating type in cell-free medium in which cells of the opposite mating type had been grown. Synchronised ce... | Fidelity of conjugation in Saccharomyces cerevisiae. An efficient method for the production of synchronous zygotes in Saccharomyces cerevisiae is described. Cells were synchronised under defined conditions in either an a, alpha mixed culture or by incubation of each mating type in cell-free medium in which cells of the... | [
-0.03123394027352333,
0.029104363173246384,
-0.04424662888050079,
-0.03579895198345184,
-0.03033400885760784,
0.03580566495656967,
-0.017263183370232582,
0.027197781950235367,
0.008197048678994179,
-0.009629390202462673,
0.03255428001284599,
-0.0657309740781784,
0.01939111016690731,
-0.054... |
PMID:27717 | Disturbance of the machinery for the gene expression by acidic pH in the repressible acid phosphatase system of Saccharomyces cerevisiae. | When the pH of growth medium containing a limited amount of inorganic phosphate is kept below 3.0, cells of Saccharomyces cerevisiae produce repressible alkaline phosphatase but no repressible acid phosphatase. The same cells produce acid phosphatase immediately on shifting the medium pH to 4.0 or above. Like intact ce... | Disturbance of the machinery for the gene expression by acidic pH in the repressible acid phosphatase system of Saccharomyces cerevisiae. When the pH of growth medium containing a limited amount of inorganic phosphate is kept below 3.0, cells of Saccharomyces cerevisiae produce repressible alkaline phosphatase but no r... | [
-0.04134923592209816,
0.029218755662441254,
-0.01788579300045967,
0.03877856954932213,
0.0062593622133135796,
-0.02953082136809826,
0.02849164791405201,
-0.013230421580374241,
0.0019261832349002361,
-0.002934802323579788,
0.024349413812160492,
-0.0746224969625473,
0.007124098017811775,
-0.... |
PMID:27721 | Differential mutagenicity of reaction products of various pyrazolones with nitrite. | Four pyrazolones in frequent use, i.e. antipyrine (AP), aminopyrine (AMP), sulpyrine (SP) and isopropylantipyrine (IPA), were compared for their reactivity with nitrite and for the in vitro mutagenicity of their reaction products by Ames' reversion tests. In various acidic solutions at 37 degrees C, AP, AMP and SP were... | Differential mutagenicity of reaction products of various pyrazolones with nitrite. Four pyrazolones in frequent use, i.e. antipyrine (AP), aminopyrine (AMP), sulpyrine (SP) and isopropylantipyrine (IPA), were compared for their reactivity with nitrite and for the in vitro mutagenicity of their reaction products by Ame... | [
-0.07514116913080215,
0.015322104096412659,
-0.002159544499590993,
0.02293677255511284,
0.005287157371640205,
-0.0062767812050879,
0.023961087688803673,
0.034818559885025024,
-0.08068982511758804,
-0.03607625886797905,
0.035098593682050705,
-0.03604386746883392,
0.02601030468940735,
0.0273... |
PMID:27728 | Substance P: binding to lipids in the brain. | 1. Substance P (SP) could be extracted from brain homogenates with chloroform-methanol by a method which extracts all lipids. 2. SP could be transferred form this total lipid extract (TLE) into an aqueous solution at low pH values (2.0--3.0). 3. At higher pH values (5.5) SP could be transferred from an aqueous phase in... | Substance P: binding to lipids in the brain. 1. Substance P (SP) could be extracted from brain homogenates with chloroform-methanol by a method which extracts all lipids. 2. SP could be transferred form this total lipid extract (TLE) into an aqueous solution at low pH values (2.0--3.0). 3. At higher pH values (5.5) SP ... | [
-0.04477144032716751,
-0.005498240701854229,
-0.006650577764958143,
-0.08784610778093338,
-0.04321971535682678,
-0.03744686767458916,
0.11371637880802155,
0.01598862186074257,
-0.04990840330719948,
-0.0013675256632268429,
0.020781902596354485,
-0.06899262219667435,
0.023607823997735977,
0.... |
PMID:27729 | The effect of some neuroleptics on the interaction of cortically and nigrally evoked potentials in the rat striatum. | The interaction of cortico- and nigrofugal inputs to the striatum of the rat was investigated using the technique of evoked potentials. Repetitive, unilateral stimulation of the substantia nigra inhibited potentials which were evoked from the ipsilateral rostral cortex and recorded from the ipsilateral striatum. The in... | The effect of some neuroleptics on the interaction of cortically and nigrally evoked potentials in the rat striatum. The interaction of cortico- and nigrofugal inputs to the striatum of the rat was investigated using the technique of evoked potentials. Repetitive, unilateral stimulation of the substantia nigra inhibite... | [
-0.02267163060605526,
0.021244296804070473,
0.01720445789396763,
0.015575861558318138,
-0.007651677820831537,
0.058500465005636215,
0.06959041953086853,
0.014524291269481182,
-0.015280036255717278,
-0.020197447389364243,
-0.014203879050910473,
-0.02294023521244526,
-0.01697644218802452,
0.... |
PMID:27734 | The treatment of anxiety with a polyfluorinated benzodiazepine derivative. | Following 4 weeks of treatment with ORF-8063 a polyfluorinated benzodiazepine derivative, 8 hospitalized patients manifesting a primary pathology of anxiety showed marked general improvement. 2 other persons were treated, but for shorter periods: 9 and 14 days. Both are included in the pre-post analysis. Mean optimal d... | The treatment of anxiety with a polyfluorinated benzodiazepine derivative. Following 4 weeks of treatment with ORF-8063 a polyfluorinated benzodiazepine derivative, 8 hospitalized patients manifesting a primary pathology of anxiety showed marked general improvement. 2 other persons were treated, but for shorter periods... | [
-0.026882989332079887,
-0.009131573140621185,
0.03868871554732323,
0.062445905059576035,
0.022286973893642426,
0.03385806828737259,
0.019634516909718513,
0.0386519618332386,
-0.011508901603519917,
-0.056926485151052475,
0.024147527292370796,
-0.0006769369938410819,
-0.024108655750751495,
-... |
PMID:27735 | Duration of apnea needed to confirm brain death. | To determine the duration of respiratory arrest needed to attain a PaCO2 level high enough to provide maximal stimulation of respiration, we evaluated changes in PaCO2, PaO2 and apH during periods of apnea lasting as long as 10 minutes in 10 apparently brain-dead subjects. Before apnea, mean PaCO2 was 33 mm Hg. In seve... | Duration of apnea needed to confirm brain death. To determine the duration of respiratory arrest needed to attain a PaCO2 level high enough to provide maximal stimulation of respiration, we evaluated changes in PaCO2, PaO2 and apH during periods of apnea lasting as long as 10 minutes in 10 apparently brain-dead subject... | [
-0.08035367727279663,
0.03908887133002281,
0.01144423522055149,
0.01316574402153492,
-0.044285815209150314,
0.04815034568309784,
0.052879855036735535,
0.0004616442311089486,
-0.016161013394594193,
-0.010627190582454205,
-0.008092710748314857,
-0.036715175956487656,
-0.0171308945864439,
0.0... |
PMID:27736 | Thiamine deficiency: selective impairment of the cerebellar serotonergic system. | To explore the role of thiamine deficiency in synaptic transmission, the high-affinity uptake and release systems for putative neurotransmitters were studied in synaptosomal preparations isolated from the telencephalon, hypothalamus, and cerebellum of rats made thiamine deficient by diet or pyrithiamine. There was sign... | Thiamine deficiency: selective impairment of the cerebellar serotonergic system. To explore the role of thiamine deficiency in synaptic transmission, the high-affinity uptake and release systems for putative neurotransmitters were studied in synaptosomal preparations isolated from the telencephalon, hypothalamus, and c... | [
-0.03756561502814293,
0.012228480540215969,
-0.04943545535206795,
0.03649270907044411,
-0.05479714274406433,
0.03471972048282623,
0.0919126570224762,
0.05157913640141487,
-0.04710535705089569,
-0.01245421078056097,
0.03114580176770687,
-0.06779716163873672,
0.050813253968954086,
0.01921668... |
PMID:27745 | [Infestation of mosquitoes from the Maritime Territory by the entomopathogenic fungus, Coelomomyces iliensis, under laboratory conditions]. | The infection of larvae of Culex pipiens molestus, C. vagans and C. tritaeniorhynchus (the vector of the virus of Japanese encephalitis) with the entomopathogenic fungus Coelomomyces iliensis from Kazakhstan was carried out in the Primorje Territory in 1973--1974. At the infection of larvae of C. tritaeniorhynchus with... | [Infestation of mosquitoes from the Maritime Territory by the entomopathogenic fungus, Coelomomyces iliensis, under laboratory conditions]. The infection of larvae of Culex pipiens molestus, C. vagans and C. tritaeniorhynchus (the vector of the virus of Japanese encephalitis) with the entomopathogenic fungus Coelomomyc... | [
0.058167148381471634,
-0.029518920928239822,
-0.0018609438557177782,
0.019554179161787033,
0.0677046999335289,
-0.050301216542720795,
0.037871044129133224,
0.12333060055971146,
-0.063946932554245,
0.012118615210056305,
-0.0025926849339157343,
-0.06282299757003784,
-0.016066009178757668,
0.... |
PMID:27752 | Interaction of peripheral and central respiratory drives in cats. I. Effects of sodium cyanide as a peripheral chemoreceptor stimulus at different levels of CSF pH. | In cats anesthetized with chloralose-urethane, the central respiratory chemoreceptors were exposed to mock CSF of pH 7.02, 7.02, or 7.57. The right carotid body was simultaneously stimulated by intracarotid injections of 40, 80, or 160 microgram sodium cyanide in 200 microliter Ringer solution. The left carotid nerve a... | Interaction of peripheral and central respiratory drives in cats. I. Effects of sodium cyanide as a peripheral chemoreceptor stimulus at different levels of CSF pH. In cats anesthetized with chloralose-urethane, the central respiratory chemoreceptors were exposed to mock CSF of pH 7.02, 7.02, or 7.57. The right carotid... | [
-0.04184243455529213,
0.009784163907170296,
-0.029118049889802933,
0.04285753145813942,
0.030572116374969482,
0.02738950215280056,
0.11324251443147659,
0.05307808890938759,
-0.04939417913556099,
0.015536141581833363,
-0.026161640882492065,
0.0002793926396407187,
0.03025173209607601,
0.0655... |
PMID:27756 | [Gastric acid secretion by vagal electrostimulation (author's transl)]. | In the operative verification of vagotomy, electrical stimulation of the vagus nerves with the study of pH should seem to be a reliable method. On the basis of an experiment in the cat, the authors emphasise the effectiveness of electrical stimulation of gastric acid secretion, confirmed by 16 clinical cases. Stimulati... | [Gastric acid secretion by vagal electrostimulation (author's transl)]. In the operative verification of vagotomy, electrical stimulation of the vagus nerves with the study of pH should seem to be a reliable method. On the basis of an experiment in the cat, the authors emphasise the effectiveness of electrical stimulat... | [
0.0524531751871109,
0.002619990613311529,
0.012672253884375095,
0.023784469813108444,
-0.03356176242232323,
0.04911511763930321,
0.059253446757793427,
0.040766485035419464,
-0.012321828864514828,
-0.03696535527706146,
-0.04814528673887253,
-0.06657199561595917,
-0.08071412891149521,
0.0531... |
PMID:27761 | Protonated polynucleotides structures - 22.CD study of the acid-base titration of poly(dG).poly(dC). | The acid-base titration (pH 8 --> pH 2.5 --> pH 8) of eleven mixing curve samples of the poly(dG) plus poly(dC) system has been performed in 0.15 M NaCl. Upon protonation, poly(dG).poly(dC) gives rise to an acid complex, in various amounts according to the origin of the sample. We have established that the hyster... | Protonated polynucleotides structures - 22.CD study of the acid-base titration of poly(dG).poly(dC). The acid-base titration (pH 8 --> pH 2.5 --> pH 8) of eleven mixing curve samples of the poly(dG) plus poly(dC) system has been performed in 0.15 M NaCl. Upon protonation, poly(dG).poly(dC) gives rise to an acid c... | [
-0.08972366154193878,
0.01444234699010849,
-0.010273955762386322,
-0.0009803337743505836,
0.03007417917251587,
0.007191766053438187,
0.03328922018408775,
-0.007087802980095148,
-0.0102513013407588,
-0.03159002587199211,
0.09141924977302551,
-0.06835140287876129,
0.01445127185434103,
-0.029... |
PMID:27762 | Protonated polynucleotides structures - 23. The acid-base hysteresis of poly(dG).poly(dC). | The large hysteresis observed during the acid-base titration of poly(dG). poly (dC) was studied by CD and potentiometric scanning curves. Intermediate scanning loops as well as the equilibrium and metastable branches of the hysteresis loop have been determined. The potentiometric titrations showed, however, that the va... | Protonated polynucleotides structures - 23. The acid-base hysteresis of poly(dG).poly(dC). The large hysteresis observed during the acid-base titration of poly(dG). poly (dC) was studied by CD and potentiometric scanning curves. Intermediate scanning loops as well as the equilibrium and metastable branches of the hyste... | [
-0.09806787222623825,
0.013776871375739574,
-0.009848746471107006,
-0.011519704945385456,
0.013059251010417938,
-0.004460733849555254,
0.05205220729112625,
0.021541744470596313,
-0.0052468013018369675,
-0.02971014566719532,
0.0583190880715847,
-0.04151202738285065,
0.04187783971428871,
-0.... |
PMID:27763 | Cross-linking of nucleosomal histones with monofunctional imidoesters. | Cross-linking experiments with the MONOfunctional imidoester methyl-acetimidate, in the pH range 7.0 - 8.0, on rat liver nucleosomes generate a cross-linking pattern almost identical with the one observed for much longer BIfunctional reagents (e.g. dimethylsuberimidate). Combined cross-linking and trypsin digestion exp... | Cross-linking of nucleosomal histones with monofunctional imidoesters. Cross-linking experiments with the MONOfunctional imidoester methyl-acetimidate, in the pH range 7.0 - 8.0, on rat liver nucleosomes generate a cross-linking pattern almost identical with the one observed for much longer BIfunctional reagents (e.g. ... | [
-0.059641432017087936,
-0.040844980627298355,
-0.028191441670060158,
-0.018675081431865692,
0.006170548498630524,
0.018972961232066154,
0.02499399147927761,
0.042287081480026245,
-0.018801268190145493,
-0.04644492268562317,
0.012907780706882477,
-0.04069957137107849,
0.02499699406325817,
0... |
PMID:27764 | An efficient in vitro total reconstitution of the Escherichia coli 50S ribosomal subunit. | A new, relatively simple technique for the total invitro reconstitution of E. coli 50S ribosomes has been developed. It is a two-step procedure like that previously reported by Nierhaus and Dohme [Proc. Natl. Acad. Sci. 71, 4713 (1974)], but it differs in a number of important aspects. Ribosomal RNA is prepared by dire... | An efficient in vitro total reconstitution of the Escherichia coli 50S ribosomal subunit. A new, relatively simple technique for the total invitro reconstitution of E. coli 50S ribosomes has been developed. It is a two-step procedure like that previously reported by Nierhaus and Dohme [Proc. Natl. Acad. Sci. 71, 4713 (... | [
-0.09662690758705139,
-0.03657969459891319,
-0.03469899296760559,
-0.02249188721179962,
-0.003345145145431161,
0.014047428034245968,
-0.004134293645620346,
0.0322488509118557,
-0.017602473497390747,
-0.012562231160700321,
-0.01148360874503851,
-0.08849973976612091,
0.021448690444231033,
-0... |
PMID:27765 | The isolation of duplex DNA fragments containing (dG.dC) clusters by chromatography on poly(rC)-Sephadex. | Duplex DNA containing oligo(dG.dC)-rich clusters can be isolated by specific binding to poly(rC)-Sephadex. This binding, probably mediated by the formation of an oligo(dG.dC)rC+ triple helix, is optimal at pH 5 in 50% formamide, 2 M LiCl; the bound DNA is recovered by elution at pH 7.5. Using this method we find that t... | The isolation of duplex DNA fragments containing (dG.dC) clusters by chromatography on poly(rC)-Sephadex. Duplex DNA containing oligo(dG.dC)-rich clusters can be isolated by specific binding to poly(rC)-Sephadex. This binding, probably mediated by the formation of an oligo(dG.dC)rC+ triple helix, is optimal at pH 5 in ... | [
-0.04250935837626457,
-0.015841899439692497,
-0.015016455203294754,
-0.025992004200816154,
0.05665716901421547,
0.01838354952633381,
0.05527518317103386,
0.038349881768226624,
-0.03635112941265106,
0.02774849906563759,
0.03953314572572708,
-0.0821569412946701,
0.020103484392166138,
-0.0215... |
PMID:27766 | Histone H1--DNA interaction. On the mechanism of DNA strands crosslinking by histone H1. | Crosslinking of DNA fibers by histone H1 or phosphorylated on Ser-37 histone H1, and by the individual fragments of the H1 polypeptide chain was studied by the method of turbidimetry. The dependence of the turbidity of DNA-protein complexes on the ionic strength in solution suggests that the condensation of H1.DNA comp... | Histone H1--DNA interaction. On the mechanism of DNA strands crosslinking by histone H1. Crosslinking of DNA fibers by histone H1 or phosphorylated on Ser-37 histone H1, and by the individual fragments of the H1 polypeptide chain was studied by the method of turbidimetry. The dependence of the turbidity of DNA-protein ... | [
-0.04902868717908859,
-0.020375963300466537,
-0.005335397552698851,
-0.017858322709798813,
-0.04929725080728531,
-0.007632601540535688,
0.06032818928360939,
-0.010179140605032444,
-0.004766562487930059,
-0.023449180647730827,
0.03565683215856552,
-0.04144120588898659,
0.031825534999370575,
... |
PMID:27767 | In vitro transcription in E. coli crude lysates prepared on cellophane discs. | An in vitro RNA-synthesizing system consisting of gently lysed E. coli cells on cellophane discs is described. The system has been optimalized with respect to total RNA synthesis. Under certain standard conditions DNA dependent RNA polymerase (EC 2.7.7.6) is responsible for the majority of the RNA synthesis. The extens... | In vitro transcription in E. coli crude lysates prepared on cellophane discs. An in vitro RNA-synthesizing system consisting of gently lysed E. coli cells on cellophane discs is described. The system has been optimalized with respect to total RNA synthesis. Under certain standard conditions DNA dependent RNA polymerase... | [
-0.0375717356801033,
-0.016817616298794746,
-0.02246895432472229,
-0.015215488150715828,
0.042461711913347244,
-0.011246414855122566,
-0.010005887597799301,
0.009292327798902988,
0.008127899840474129,
0.02595493011176586,
0.004298907704651356,
-0.024362929165363312,
-0.004390025045722723,
... |
PMID:27775 | Hospital phobia: a rapid desensitization technique. | The less disabling phobias do not normally present a problem in that the stimulus may be avoided. This would also apply to hospital phobia until an acute medical or surgical problem might arise, when avoidance could constitute a direct threat to life. Although phobic illness is a common problem the small number of case... | Hospital phobia: a rapid desensitization technique. The less disabling phobias do not normally present a problem in that the stimulus may be avoided. This would also apply to hospital phobia until an acute medical or surgical problem might arise, when avoidance could constitute a direct threat to life. Although phobic ... | [
0.006639138329774141,
0.01553171593695879,
0.022282147780060768,
0.049720801413059235,
0.043738119304180145,
-0.000221878188312985,
0.12273827940225601,
0.055718354880809784,
0.002054402371868491,
-0.031075915321707726,
0.028075166046619415,
0.009748117998242378,
-0.025628123432397842,
0.0... |
PMID:27779 | [Effect of cultivation temperature and pH on the biosynthesis of extracellular phosphohydrolases by the culture Penicillium brevi-compactum]. | The effect of cultivation temperature and pH on growth of the culture Penicillium brevi-compactum and biosynthesis of extracellular phosphohydrolases (acid and alkaline RNases and acid PMEase) involved in RNA degradation was studied. The maximum growth of the culture was seen at 30 degrees and pA-7.0 and its maximum ph... | [Effect of cultivation temperature and pH on the biosynthesis of extracellular phosphohydrolases by the culture Penicillium brevi-compactum]. The effect of cultivation temperature and pH on growth of the culture Penicillium brevi-compactum and biosynthesis of extracellular phosphohydrolases (acid and alkaline RNases an... | [
-0.0367853157222271,
0.02688869833946228,
0.02761177532374859,
0.009549105539917946,
0.05448248237371445,
-0.04063594713807106,
-0.0448005236685276,
0.05486001819372177,
-0.04955640435218811,
0.018426066264510155,
0.0237723495811224,
-0.050570957362651825,
0.03920765593647957,
-0.047983098... |
PMID:27783 | Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase. | Highly purified poly(A) polymerase (polynucleotide adenylyltransferase, EC 2.7.7.19), which synthesizes poly(A) from ATP substrate, can also catalyze hydrolysis of poly(A). The enzyme, designated as poly(A) hydrolase, requires either Mn2+ or Mg2+ for activity. Although AMP is the predominant product of the reaction, AD... | Hydrolysis of poly (A) to adenine nucleotides by purified poly (A) polymerase. Highly purified poly(A) polymerase (polynucleotide adenylyltransferase, EC 2.7.7.19), which synthesizes poly(A) from ATP substrate, can also catalyze hydrolysis of poly(A). The enzyme, designated as poly(A) hydrolase, requires either Mn2+ or... | [
-0.08802127093076706,
0.008392220363020897,
-0.006331016309559345,
0.00377280474640429,
-0.009726687334477901,
-0.011097635142505169,
0.02717016451060772,
0.04528369754552841,
-0.02600761689245701,
0.011139649897813797,
0.07579029351472855,
-0.060948632657527924,
-0.0333976224064827,
-0.04... |
PMID:27780 | [Examination of the action of effectors after storing glutamine synthetase from the fodder yeast Candida tropicalis at room temperature]. | The pattern of action of effectors (AMP, IMP, CMP, anthranilic acid, tryptophane, alanine, glutamine, glycine, histidine) and glutamine synthetase (GS) extracted from the fodder yeast Candida tropicalis and stored at room temperature for 1.5-2 hrs was examined. As regards the action of effectors on GS after its exposur... | [Examination of the action of effectors after storing glutamine synthetase from the fodder yeast Candida tropicalis at room temperature]. The pattern of action of effectors (AMP, IMP, CMP, anthranilic acid, tryptophane, alanine, glutamine, glycine, histidine) and glutamine synthetase (GS) extracted from the fodder yeas... | [
-0.05078163743019104,
0.004852514248341322,
0.02719629742205143,
0.015978634357452393,
0.016719041392207146,
0.0032274750992655754,
0.03380005061626434,
0.0483003668487072,
-0.07549482583999634,
0.008662636391818523,
0.021343093365430832,
-0.040128193795681,
-0.017437689006328583,
0.016731... |
PMID:27781 | [Kinetics and stability of glucooxidase from Penicillium vitale]. | The kinetics, thermal stability and ultrasonic resistance of glucosoxidase from Penicillium vitale have been investigated. Its oxidative constant is close to, catalytic constant is 1.7 times less and the reductive constant is 5.4 times more than the respective constants of the enzyme from Aspergillus niger. The relatio... | [Kinetics and stability of glucooxidase from Penicillium vitale]. The kinetics, thermal stability and ultrasonic resistance of glucosoxidase from Penicillium vitale have been investigated. Its oxidative constant is close to, catalytic constant is 1.7 times less and the reductive constant is 5.4 times more than the resp... | [
-0.03782341629266739,
-0.014223034493625164,
-0.004685068503022194,
0.022741829976439476,
0.05127851292490959,
-0.005532088689506054,
0.0271869245916605,
0.04927023872733116,
-0.04720364883542061,
-0.01612936146557331,
-0.041575755923986435,
-0.016440141946077347,
0.02010710909962654,
-0.0... |
PMID:27784 | Isolation of a low molecular weight Ca2+ carrier from calf heart inner mitochondrial membrane. | A protein was isolated from calf heart inner mitochondrial membrane with the aid of an electron paramagnetic resonance assay based on the relative binding properties of Ca2+, Mn2+, and Mg2+ to the protein. The molecular weight of this protein has been estimated to be about 3000 by urea/sodium dodecyl sulfate gel electr... | Isolation of a low molecular weight Ca2+ carrier from calf heart inner mitochondrial membrane. A protein was isolated from calf heart inner mitochondrial membrane with the aid of an electron paramagnetic resonance assay based on the relative binding properties of Ca2+, Mn2+, and Mg2+ to the protein. The molecular weigh... | [
-0.08685702830553055,
-0.03613768517971039,
-0.06342794001102448,
-0.02346985787153244,
-0.021615182980895042,
-0.04548084735870361,
0.05891909450292587,
0.0560312382876873,
-0.00372044974938035,
0.0006041786982677877,
0.03399405628442764,
-0.10488662123680115,
0.0016476797172799706,
0.048... |
PMID:27785 | 31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. | 31P nuclear magnetic resonance spectra of glycolyzing, anaerobic Escherichia coli cells and their perchloric acid extracts were obtained at 145.7 MHz. Time-dependent intracellular concentrations of nucleoside di- and triphosphates, Pi, and sugar phosphates were measured during glycolysis with 2-min resolution, while in... | 31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. 31P nuclear magnetic resonance spectra of glycolyzing, anaerobic Escherichia coli cells and their perchloric acid extracts were obtained at 145.7 MHz. Time-dependent intracellular concentrations of nucleoside di-... | [
-0.10255764424800873,
0.03329981490969658,
-0.006877094507217407,
0.002582161221653223,
0.03898025304079056,
-0.026074569672346115,
0.00807215366512537,
0.012106458656489849,
-0.009333613328635693,
-0.01747291348874569,
0.050273340195417404,
-0.0697065219283104,
0.0013013554271310568,
0.02... |
PMID:27786 | Selective labeling of alpha-adrenergic receptors in caudate nucleus by [3H] dihydroergocryptine in the presence of spiperone-blocked dopamine receptors. | Because it was known that [(3)H]dihydroergocryptine can label alpha-adrenergic receptors as well as dopamine receptors, this study was done to establish the conditions under which [(3)H]dihydroergocryptine would be a reliable ligand for selective labeling of alpha-adrenergic receptors. The calf caudate was chosen becau... | Selective labeling of alpha-adrenergic receptors in caudate nucleus by [3H] dihydroergocryptine in the presence of spiperone-blocked dopamine receptors. Because it was known that [(3)H]dihydroergocryptine can label alpha-adrenergic receptors as well as dopamine receptors, this study was done to establish the conditions... | [
-0.03183788061141968,
0.0002926882589235902,
-0.0403386652469635,
0.03330700099468231,
-0.03374403715133667,
-0.006340597756206989,
0.044614505022764206,
0.06297332048416138,
0.008426418527960777,
-0.024170491844415665,
0.03160577267408371,
-0.06609125435352325,
-0.01143999956548214,
0.097... |
PMID:27787 | Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher disease. | Biochemical investigations were performed on autopsy tissues obtained from an 11-year-old girl who died with the juvenile, subacute neuropathic form of Gaucher disease. In addition to the expected deficiency of glucocerebrosidase activity, extracts of both liver and kidney from this individual displayed a profound (gre... | Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher disease. Biochemical investigations were performed on autopsy tissues obtained from an 11-year-old girl who died with the juvenile, subacute neuropathic form of Gaucher disease. In addition to the expected deficiency of glucocerebrosidase activity... | [
-0.010092242620885372,
-0.03631838783621788,
0.032453544437885284,
0.027174772694706917,
0.027077602222561836,
-0.028245801106095314,
-0.006937867496162653,
0.08128219842910767,
-0.01914001815021038,
-0.05070282891392708,
0.01790846325457096,
-0.06727765500545502,
-0.07620511949062347,
-0.... |
PMID:27788 | Reduction of membrane potential, an immediate effect of colicin K. | Colicin K causes a rapid and drastic reduction of the membrane potential of Escherichia coli cells, as measured by the uptake of the lipophilic cation triphenylmethylphosphonium. The colicin causes no major changes in the pH gradient, as measured by the uptake of butyric acid. The decrease in membrane potential followi... | Reduction of membrane potential, an immediate effect of colicin K. Colicin K causes a rapid and drastic reduction of the membrane potential of Escherichia coli cells, as measured by the uptake of the lipophilic cation triphenylmethylphosphonium. The colicin causes no major changes in the pH gradient, as measured by the... | [
-0.1094646006822586,
-0.04291938245296478,
0.0616658478975296,
0.06659165769815445,
0.011966695077717304,
-0.0829070582985878,
0.03156716749072075,
0.060041654855012894,
-0.020870286971330643,
-0.017761260271072388,
0.05047963559627533,
-0.04662582650780678,
0.04605036973953247,
0.00288607... |
PMID:27820 | Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats. | The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats selectively inbred to the F8 generation for alcohol preference (P) and non-preference (NP... | Neurochemical and operant behavioral studies of a strain of alcohol-preferring rats. The levels of serotonin (5-HT), 5-hydroxyindoleacetic acid, tyrosine (TYR), norepinephrine (NE), acetylcholine, GABA, glutamate (GLU), aspartate (ASP), alanine, glycine (GLY) and taurine were measured in the CNS of adult male rats sele... | [
0.007899261079728603,
0.00804830901324749,
-0.017667416483163834,
-0.030304674059152603,
-0.017436260357499123,
0.07120929658412933,
0.09568079560995102,
0.05851712077856064,
-0.010603501461446285,
-0.054343800991773605,
0.0043415650725364685,
-0.012701747938990593,
-0.054565172642469406,
... |
PMID:27827 | [Anxiety- an approach to defining terms and formulating a methodological concept for measuring anxiety states within the framework of clinical trials with anxiolytic substances (author's transl)]. | A methodological concept for measuring anxiety states and changes in anxiety states in clinical studies with anxiolytic substances is presented: Effectivity should be evaluated on several levels which include emotions, objects of anxiety, psychophysiology, biochemistry, and observed behavior. This test concept is based... | [Anxiety- an approach to defining terms and formulating a methodological concept for measuring anxiety states within the framework of clinical trials with anxiolytic substances (author's transl)]. A methodological concept for measuring anxiety states and changes in anxiety states in clinical studies with anxiolytic sub... | [
0.004354072269052267,
0.029769986867904663,
0.0519743375480175,
0.06708578020334244,
-0.0065316553227603436,
0.050892528146505356,
0.12026650458574295,
-0.003440823871642351,
0.02249876968562603,
-0.06128298118710518,
0.030975542962551117,
-0.007711504586040974,
-0.00947277620434761,
0.045... |
PMID:27823 | Determination of mepyramine, aminophenazone, nialamide and chloroquine using the deltapj method. | Mepyramine maleate, aminophenazone, nialamide and chloroquine phosphate are examples of compounds which do not fulfil the requirements of the delta A method. By the proper choice of polynomial and wavelengths, the deltapj method has been successfully applied to their determination. The mean percentage recoveries were f... | Determination of mepyramine, aminophenazone, nialamide and chloroquine using the deltapj method. Mepyramine maleate, aminophenazone, nialamide and chloroquine phosphate are examples of compounds which do not fulfil the requirements of the delta A method. By the proper choice of polynomial and wavelengths, the deltapj m... | [
-0.07560838758945465,
0.005211037117987871,
0.021089397370815277,
-0.01048201322555542,
-0.021786896511912346,
0.0071884216740727425,
0.09742947667837143,
0.05037546157836914,
-0.04820771515369415,
0.001457530539482832,
0.03234881907701492,
-0.03242340311408043,
0.02280459553003311,
0.0331... |
PMID:27828 | Autonomic perception and responses in anxiety-inducing situations. | The anxiolytic and sedative properties of a thienodiazepine (clotiazepam) were investigated in 40 healthy subjects with varying degrees of arousal and with the aid of specific anxiety-inducing conditions. A cross-over design with a double blind technique was used. EEG, heart and respiratory rate, peripheral pulse volum... | Autonomic perception and responses in anxiety-inducing situations. The anxiolytic and sedative properties of a thienodiazepine (clotiazepam) were investigated in 40 healthy subjects with varying degrees of arousal and with the aid of specific anxiety-inducing conditions. A cross-over design with a double blind techniqu... | [
-0.03615464270114899,
0.027186265215277672,
0.06406083703041077,
0.0722595825791359,
0.01110004261136055,
0.04320315271615982,
0.12358524650335312,
-0.02417130395770073,
-0.016634294763207436,
-0.05894416570663452,
-0.019051339477300644,
0.009038392454385757,
0.006649223156273365,
0.050562... |
PMID:27829 | [Treatment of pain with psychotropic drugs (author's transl)]. | 30 patients suffering from therapy-resistant chronic pain were divided into three groups according to drive and mood: I. psychomotor inhibition combined with depressive mood, II. agitation and depressive mood, III. agitation combined normal mood. The psychopharmacological treatment of pain showed sufficient results, wh... | [Treatment of pain with psychotropic drugs (author's transl)]. 30 patients suffering from therapy-resistant chronic pain were divided into three groups according to drive and mood: I. psychomotor inhibition combined with depressive mood, II. agitation and depressive mood, III. agitation combined normal mood. The psycho... | [
-0.03722906485199928,
0.050312478095293045,
0.031517207622528076,
0.041573669761419296,
-0.026770543307065964,
0.01710427738726139,
0.05334912985563278,
0.03995555266737938,
-0.02403390221297741,
-0.02997417002916336,
0.047808125615119934,
0.016720440238714218,
0.012797328643500805,
0.0117... |
PMID:27832 | Early diagnosis of crepitant gangrene caused by Bacteroides melaninogenicus. | A rapid non-invasive test for the presence of B. melaninogenicus in the wounds of crepitant non-clostridial gangrene is described. The wounds are viewed under an ultraviolet light, and the presence of bright red fluorescene indicates the probable presence of B. melaninogenicus. | Early diagnosis of crepitant gangrene caused by Bacteroides melaninogenicus. A rapid non-invasive test for the presence of B. melaninogenicus in the wounds of crepitant non-clostridial gangrene is described. The wounds are viewed under an ultraviolet light, and the presence of bright red fluorescene indicates the proba... | [
-0.026420513167977333,
0.03957551345229149,
-0.018479734659194946,
0.010280430316925049,
0.09516005218029022,
-0.045033637434244156,
0.05177167430520058,
0.09938083589076996,
-0.06671467423439026,
-0.036722809076309204,
0.0609494224190712,
-0.05402600020170212,
-0.03203309699892998,
0.0201... |
PMID:27830 | The effects of TAB and of adrenergic blocking drugs on the course of the experimental irradiation disease. | The experiment is aimed at establishing the consequences of the endotoxic stress (TAB) associated with alpha- or beta-adrenergic selective blocking drugs on the course of the acute irradiation disease in rats (700R, gamma rad Co60). TAB administered before or after irradiation, alone or associated with propranolol, inc... | The effects of TAB and of adrenergic blocking drugs on the course of the experimental irradiation disease. The experiment is aimed at establishing the consequences of the endotoxic stress (TAB) associated with alpha- or beta-adrenergic selective blocking drugs on the course of the acute irradiation disease in rats (700... | [
-0.06624048948287964,
0.0057563865557312965,
0.02437227964401245,
0.039493490010499954,
0.03645775839686394,
-0.01485331729054451,
0.08315852284431458,
0.01996597833931446,
-0.047996580600738525,
-0.08038201928138733,
0.008240584284067154,
0.01532921101897955,
-0.012788129970431328,
0.0859... |
PMID:27831 | Some neural effects of adenosin. | The possible neural effects of adenosine were investigated by using electrophysiological techniques at the level of some central and peripheral synapses. The evoked potentials in the somatosensorial cerebral cortex are influenced according to both the type of administration and the level of the electrical stimulation. ... | Some neural effects of adenosin. The possible neural effects of adenosine were investigated by using electrophysiological techniques at the level of some central and peripheral synapses. The evoked potentials in the somatosensorial cerebral cortex are influenced according to both the type of administration and the leve... | [
-0.012533077038824558,
-0.019681580364704132,
0.05339342728257179,
0.007600731216371059,
-0.04729118570685387,
0.04568760469555855,
0.06223307177424431,
0.03772076219320297,
0.012686350382864475,
-0.06874877959489822,
0.037221264094114304,
-0.006374798249453306,
-0.05549202114343643,
0.013... |
PMID:27835 | Use of antianxiety agents in anxious outpatients. | The present paper reviews the role of antianxiety agents in the treatment of nonpsychotic anxious patients. Major emphasis is placed on findings from clinical trials conducted by this research group. Consideration is given to the relative efficacy of available antianxiety agents, to patients response in relation to pat... | Use of antianxiety agents in anxious outpatients. The present paper reviews the role of antianxiety agents in the treatment of nonpsychotic anxious patients. Major emphasis is placed on findings from clinical trials conducted by this research group. Consideration is given to the relative efficacy of available antianxie... | [
0.006323482375591993,
0.048099711537361145,
0.0018805828876793385,
0.03151163458824158,
-0.020567119121551514,
0.011995291337370872,
0.08909714967012405,
0.037366386502981186,
-0.009676157496869564,
-0.05384380742907524,
0.025640171021223068,
0.03208586573600769,
0.03715870529413223,
-0.00... |
PMID:27836 | Neuropharmacological profile of clobazam, a new 1',5'-benzodiazepine. | The effect of the new 1,5-benzodiazepine clobazam on visual evoked potentials (VEP) and spontaneous EEG in the conscious rabbit and on spinal polysynaptic reflexes in the decerebrated cat was studied in comparison to the 1,4-benzodiazepine diazepam. Clobazam was half as potent as diazepam in depressing the amplitude of... | Neuropharmacological profile of clobazam, a new 1',5'-benzodiazepine. The effect of the new 1,5-benzodiazepine clobazam on visual evoked potentials (VEP) and spontaneous EEG in the conscious rabbit and on spinal polysynaptic reflexes in the decerebrated cat was studied in comparison to the 1,4-benzodiazepine diazepam. ... | [
-0.051546718925237656,
-0.02936381846666336,
0.0544540174305439,
0.07311638444662094,
-0.004931648727506399,
0.07410912215709686,
0.03620776906609535,
0.042772792279720306,
-0.02510840818285942,
-0.033662278205156326,
-0.0056291744112968445,
-0.021121785044670105,
0.009255139157176018,
0.0... |
PMID:27846 | Studies on cholesterol esterification in human tissues. | In vitro cholesteryl synthesis from oleic acid [1-14C] was studied with enzyme preparations from human thoracic aorta and liver. Results from studies on the properties of the esterifying system provide good evidence that the mechanism involves fatty acyl-CoA-cholesterol acyl transferase. In studies on human thoracic ao... | Studies on cholesterol esterification in human tissues. In vitro cholesteryl synthesis from oleic acid [1-14C] was studied with enzyme preparations from human thoracic aorta and liver. Results from studies on the properties of the esterifying system provide good evidence that the mechanism involves fatty acyl-CoA-chole... | [
-0.0054094563238322735,
0.01197532657533884,
-0.04227312281727791,
-0.00024756690254434943,
-0.003146375995129347,
-0.03350144997239113,
0.026389578357338905,
0.06061510369181633,
-0.01047286856919527,
-0.045767199248075485,
0.047449152916669846,
-0.10655631124973297,
0.013790261000394821,
... |
PMID:27847 | Inhibition of acute anaphylaxis in the chicken by anti-allergic drugs. | The anti-anaphylactic effects of four potential anti-allergic agents (DSCG: disodium cromoglycate, PRD-92-EA, M&B 22,948 and DECC: diethylcarbamazine citrate) were studied on cardiovascular responses of acute systemic anaphylaxis and chemical mediators of immediate hypersensitivity in chickens. Compounds M&B 22... | Inhibition of acute anaphylaxis in the chicken by anti-allergic drugs. The anti-anaphylactic effects of four potential anti-allergic agents (DSCG: disodium cromoglycate, PRD-92-EA, M&B 22,948 and DECC: diethylcarbamazine citrate) were studied on cardiovascular responses of acute systemic anaphylaxis and chemical me... | [
-0.06035428121685982,
0.004681862890720367,
-0.02709812857210636,
0.036560624837875366,
0.034894052892923355,
0.003490883857011795,
0.06659918278455734,
0.04422125965356827,
-0.09098207205533981,
-0.10146202892065048,
-0.003299400908872485,
-0.03892439603805542,
0.04163571074604988,
0.0109... |
PMID:27848 | Comparison of the mechanisms controlling intracellular pH and sodium in snail neurones. | Ion-sensitive microelectrodes were used to record intracellular pH, Na+ and Cl- in snail neurones. NaCl or HCl was injected iontophoretically to compare the Na pump with the pHi regulating system. The Na pump was inhibited by ouabain, carbonyl cyanide m-chlorophenyl hydrazone and increasing the membrane potential, wher... | Comparison of the mechanisms controlling intracellular pH and sodium in snail neurones. Ion-sensitive microelectrodes were used to record intracellular pH, Na+ and Cl- in snail neurones. NaCl or HCl was injected iontophoretically to compare the Na pump with the pHi regulating system. The Na pump was inhibited by ouabai... | [
-0.04328552260994911,
-0.060161102563142776,
-0.031234897673130035,
0.011820782907307148,
0.009780344553291798,
-0.038373108953237534,
0.06833043694496155,
0.0042261602357029915,
-0.03718513622879982,
0.029065990820527077,
0.0020829266868531704,
-0.06929711997509003,
0.028306076303124428,
... |
PMID:27849 | Intracellular acid-base state at a variable temperature in air-breathing vertebrates and its representation. | When temperature changes are superimposed on changes in the control variables of acid-base state (PCO2, strong ion difference), the understanding of acid-base changes becomes difficult. A solution has recently been proposed for blood (Malan, 1977); it was based on the assumption that closed system conditions correspond... | Intracellular acid-base state at a variable temperature in air-breathing vertebrates and its representation. When temperature changes are superimposed on changes in the control variables of acid-base state (PCO2, strong ion difference), the understanding of acid-base changes becomes difficult. A solution has recently b... | [
-0.05284624174237251,
-0.03370850160717964,
0.05217295140028,
0.04646396264433861,
0.05019313097000122,
-0.010390623472630978,
0.05320495367050171,
0.026131512597203255,
0.0025335790123790503,
-0.005449056625366211,
0.04071793705224991,
-0.12693381309509277,
0.0037952763959765434,
0.063661... |
PMID:27850 | Regulation of blood pH in teleost fish. | The nature of pH changes with temperature is similar in both air-breathing and water-breathing poikilotherms having a pH-temperature slope of -0.015 to 0.020 U/degrees C. The means by which this is accomplished are quite different in the two groups. The air-breather behaves in vivo as a Rosenthal, or constant CO2 conte... | Regulation of blood pH in teleost fish. The nature of pH changes with temperature is similar in both air-breathing and water-breathing poikilotherms having a pH-temperature slope of -0.015 to 0.020 U/degrees C. The means by which this is accomplished are quite different in the two groups. The air-breather behaves in vi... | [
-0.04181647300720215,
-0.004027157090604305,
0.0299797672778368,
0.062066543847322464,
-0.0035980346146970987,
-0.0261622853577137,
0.0983147919178009,
0.03129253908991814,
-0.08551260083913803,
-0.01666226238012314,
0.0243853610008955,
-0.09256572276353836,
0.03586267679929733,
0.02888980... |
PMID:27851 | Weak acids, weak bases and intracellular pH. | Against the background of classical observations made 50 years ago, a brief review is offered of some of the work performed in the author's laboratory on the behavior of weak acids and bases towards living animal cells. The significance of membrane permeability of the charged partner of these electrolytes is pointed ou... | Weak acids, weak bases and intracellular pH. Against the background of classical observations made 50 years ago, a brief review is offered of some of the work performed in the author's laboratory on the behavior of weak acids and bases towards living animal cells. The significance of membrane permeability of the charge... | [
-0.035069528967142105,
-0.02648083120584488,
-0.03773024305701256,
0.04477691650390625,
-0.020056728273630142,
0.005300275515764952,
0.05796824395656586,
0.007046814076602459,
0.024619923904538155,
-0.03044457547366619,
0.040521010756492615,
-0.08377968519926071,
0.03964263200759888,
0.051... |
PMID:27852 | Evaluation of the DMO method for measuring intracellular pH. | Intracellular pH in single muscle fibres from Balanus nubilus was determined, both by the weak acid distribution method (using 5,5-dimethyl-2,4-oxazolidine dione) and by means of a glass pH microelectrode, following prolonged equilibrations in normal, acid or alkaline Ringer solutions. In the DMO method [3H]inulin was ... | Evaluation of the DMO method for measuring intracellular pH. Intracellular pH in single muscle fibres from Balanus nubilus was determined, both by the weak acid distribution method (using 5,5-dimethyl-2,4-oxazolidine dione) and by means of a glass pH microelectrode, following prolonged equilibrations in normal, acid or... | [
-0.051785267889499664,
-0.036675699055194855,
0.05315791815519333,
0.001262211357243359,
0.056340981274843216,
0.003035104600712657,
0.06272757798433304,
0.015149388462305069,
0.012145470827817917,
-0.01482949685305357,
0.032526835799217224,
-0.1510896384716034,
0.001444377121515572,
0.014... |
PMID:27853 | Intracellular pH transients induced by Co2 or NH3. | Experiments are reviewed in which intracellular pH (pHi), during exposure of a cell to CO2- or NH3-containing solutions, not only undergoes an acidification of alkalinization, respectively, but tends to return toward its original value and, upon removal of the test solution, rebounds to a value more alkaline or acid, r... | Intracellular pH transients induced by Co2 or NH3. Experiments are reviewed in which intracellular pH (pHi), during exposure of a cell to CO2- or NH3-containing solutions, not only undergoes an acidification of alkalinization, respectively, but tends to return toward its original value and, upon removal of the test sol... | [
-0.05444065108895302,
-0.005182999651879072,
-0.01793021522462368,
0.05219021439552307,
0.029965046793222427,
-0.014466071501374245,
0.06537162512540817,
-0.0030525976326316595,
0.0057617961429059505,
0.014598801732063293,
0.00022620383242610842,
-0.06409186869859695,
-0.02251763455569744,
... |
PMID:27854 | Intracellular buffering. | In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to betaa, while heterogeneity ... | Intracellular buffering. In the quantification of buffering the distinct roles of bicarbonate and of other buffers must be taken into account. The determination of the total non-bicarbonate buffer value, betaa, in intact tissues is complicated by active pH regulation and by heterogeneity of cytoplasm with respect to be... | [
-0.06101856380701065,
-0.02248326689004898,
0.013574632816016674,
-0.03858811780810356,
0.012247269041836262,
-0.039151474833488464,
0.07221712172031403,
0.026647938415408134,
0.009331300854682922,
0.014973222278058529,
0.03028200753033161,
-0.1587587594985962,
-0.01433468982577324,
0.0858... |
PMID:27855 | Active control of intracellular pH. | When the interior of a squid giant axon is loaded with acid, the cell responds by extruding that acid in an energy-requiring process. Our results indicate that this acid extrusion is accomplished by exchanging external HCO3- for internal Cl- at the expense of ATP. | Active control of intracellular pH. When the interior of a squid giant axon is loaded with acid, the cell responds by extruding that acid in an energy-requiring process. Our results indicate that this acid extrusion is accomplished by exchanging external HCO3- for internal Cl- at the expense of ATP. | [
-0.05323373153805733,
-0.023054752498865128,
-0.004808647558093071,
0.019304772838950157,
-0.019990772008895874,
-0.01970951072871685,
0.09758396446704865,
0.009811030700802803,
-0.0476139634847641,
0.009732608683407307,
0.05253558233380318,
-0.078916996717453,
-0.007914025336503983,
0.035... |
PMID:27856 | Measurement of intracellular pH and aspects of its control in higher plant cells cultivated in liquid medium. | The 5,5-dimethyloxazolidine-2,4-dione (DMO) method for the determination of intracellular pH has been adapted to Acer pseudoplatanus cells cultivated in liquid medium. DMO is metabolized by these cells and this parameter has to be taken into account in the measurement of the intracellular concentration of free DMO. As ... | Measurement of intracellular pH and aspects of its control in higher plant cells cultivated in liquid medium. The 5,5-dimethyloxazolidine-2,4-dione (DMO) method for the determination of intracellular pH has been adapted to Acer pseudoplatanus cells cultivated in liquid medium. DMO is metabolized by these cells and this... | [
-0.026985982432961464,
-0.014382179826498032,
0.05081978067755699,
-0.004846193827688694,
0.049352873116731644,
-0.025059975683689117,
0.061066899448633194,
-0.0298373531550169,
-0.01942293904721737,
-0.0034283092245459557,
0.028418496251106262,
-0.10599476844072342,
0.04308563470840454,
0... |
PMID:27857 | Independent and dependent variables of acid-base control. | Basic physical principles and concepts plus computer-implemented numberical techniques now make possible a thorough quantitative analysis of acid-base systems. Some important conclusions from that analysis are presented: 1. Acid-base balance for physiological solutions hould be defined as the value of [OH-]/[H+]. 2. pH... | Independent and dependent variables of acid-base control. Basic physical principles and concepts plus computer-implemented numberical techniques now make possible a thorough quantitative analysis of acid-base systems. Some important conclusions from that analysis are presented: 1. Acid-base balance for physiological so... | [
-0.07922019809484482,
-0.007745963986963034,
-0.03189152479171753,
0.029239874333143234,
0.02354445308446884,
-0.07216828316450119,
0.09246769547462463,
0.0434906929731369,
0.005359933711588383,
0.0015454902313649654,
0.07468463480472565,
-0.07357309758663177,
-0.0028323442675173283,
0.045... |
PMID:27860 | [Pathological and compensatory processes in the cerebral circulation during blood transfusion shock]. | In experiments on dogs the intravenous injection of heterogenous blood resulted in a decrease of total arterial pressure, weakening of the brain blood flow, fall of Po2 and pH in the brain cortex. A simultaneous constriction if inner carotid arteries is depending on direct action on the vascular wall of heterogenous pr... | [Pathological and compensatory processes in the cerebral circulation during blood transfusion shock]. In experiments on dogs the intravenous injection of heterogenous blood resulted in a decrease of total arterial pressure, weakening of the brain blood flow, fall of Po2 and pH in the brain cortex. A simultaneous constr... | [
-0.026056960225105286,
0.03500630706548691,
-0.04018145427107811,
0.004691231995820999,
0.011410163715481758,
-0.0000025895556063915137,
0.06780882924795151,
0.046370554715394974,
0.0023533969651907682,
-0.015961904078722,
0.0010641783010214567,
-0.0336625874042511,
0.01127924770116806,
-0... |
PMID:27862 | [Gastric secretion and gastrin values following portocaval and splenocaval shunts in the rat]. | The basal and gastrin-stimulated gastric acid output was measured in rats with a distal splenocaval shunt. In addition, serum gastrin levels were determined in rats with splenocaval and portacaval shunts. The rise in gastric acid output with increasing gastrin dosage was the same in rats with splenocaval shunt as in th... | [Gastric secretion and gastrin values following portocaval and splenocaval shunts in the rat]. The basal and gastrin-stimulated gastric acid output was measured in rats with a distal splenocaval shunt. In addition, serum gastrin levels were determined in rats with splenocaval and portacaval shunts. The rise in gastric ... | [
0.01002527866512537,
-0.007643616292625666,
0.007782229222357273,
0.008299079723656178,
0.02915607951581478,
-0.014357567764818668,
0.04350285604596138,
0.0671260803937912,
-0.03479303792119026,
-0.024655917659401894,
-0.004446892999112606,
-0.08429443836212158,
-0.02368900366127491,
0.029... |
PMID:27863 | [Preventive practice in dentistry and its current meaning]. | Improvements in the field of sealants and of adhesive restorations based thereon represent the most important new development in preventive dentistry. Caries prevention by means of better nutritional habits is greatly enhanced by newly developed and marketed sugar-free and tooth sparing products. Statistical mortality ... | [Preventive practice in dentistry and its current meaning]. Improvements in the field of sealants and of adhesive restorations based thereon represent the most important new development in preventive dentistry. Caries prevention by means of better nutritional habits is greatly enhanced by newly developed and marketed s... | [
-0.028922492638230324,
0.013968450948596,
0.03574693202972412,
0.01869898848235607,
0.031221292912960052,
0.014304900541901588,
-0.017629405483603477,
0.07877175509929657,
-0.04976700618863106,
-0.008367368951439857,
-0.008230851963162422,
-0.06342767179012299,
0.05103956535458565,
-0.0032... |
PMID:27864 | Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia. | Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by ... | Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia. Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. ... | [
-0.0206619780510664,
-0.006148113869130611,
-0.02887408621609211,
0.02919889986515045,
-0.03827601671218872,
-0.031680796295404434,
0.05376475304365158,
0.10380218178033829,
-0.05163920298218727,
-0.054838329553604126,
0.014705860987305641,
-0.04339893162250519,
-0.011649479158222675,
-0.0... |
PMID:27879 | The abnormalities of beta-galactosidase in GM1-gangliosidoses. | The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose. In the cases of GM1-gangliosidosis Types 1 and 2A the activity was less than 0.5% of the control. In the liver of GM1-gangliosidosis Type 2B the activi... | The abnormalities of beta-galactosidase in GM1-gangliosidoses. The activity of GM1 beta-galactosidase in the brain and liver of patients with GM1-gangliosidosis was assayed using GM1-ganglioside tritiated in the terminal galactose. In the cases of GM1-gangliosidosis Types 1 and 2A the activity was less than 0.5% of the... | [
0.006084551569074392,
-0.030396703630685806,
0.045488934963941574,
-0.034139685332775116,
-0.011173981241881847,
-0.030114511027932167,
0.01570938155055046,
0.04876973107457161,
-0.05556325614452362,
-0.05461997911334038,
0.0075730206444859505,
-0.0700293779373169,
-0.06155044957995415,
0.... |
PMID:27884 | Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia. | Changes in cerebral cortex concentrations of high-energy phosphates, glycolytic metabolites, citric acid cycle intermediates, associated amino acids, and ammonia, were studied after 5, 15 and 30 min of incomplete ischemia in rats anesthetized with 70% N2O or 150 mg.kg-1 of phenobartibal. Previous results have shown tha... | Effects of phenobarbital in cerebral ischemia. Part I: cerebral energy metabolism during pronounced incomplete ischemia. Changes in cerebral cortex concentrations of high-energy phosphates, glycolytic metabolites, citric acid cycle intermediates, associated amino acids, and ammonia, were studied after 5, 15 and 30 min ... | [
-0.03880583122372627,
0.02679198421537876,
0.02300526760518551,
0.053814418613910675,
-0.03425183147192001,
0.02721487171947956,
0.03848639503121376,
0.027191681787371635,
0.005257075652480125,
0.03508026897907257,
0.019954880699515343,
-0.054447516798973083,
-0.007896928116679192,
0.05919... |
PMID:27891 | Inhibition of 3'-methyl-4-dimethylaminoazobenezene-induced hepatocarcinogenesis by portacaval shunt. | Adult male Sprague Dalwey rats on which end-to-side portacaval shunt (PCS) operation was performed did not hyperplastic nodules and hepatoms when they were fed 3'-methyl-4-dimethylaminoazobenzene in semisynthetic basal diet for periods of up to 169 days. In contrast, all the intact rats fed the same diet for only 75 da... | Inhibition of 3'-methyl-4-dimethylaminoazobenezene-induced hepatocarcinogenesis by portacaval shunt. Adult male Sprague Dalwey rats on which end-to-side portacaval shunt (PCS) operation was performed did not hyperplastic nodules and hepatoms when they were fed 3'-methyl-4-dimethylaminoazobenzene in semisynthetic basal ... | [
-0.008098747581243515,
-0.012727244757115841,
0.016050351783633232,
0.03326968848705292,
0.023638028651475906,
-0.019878823310136795,
0.03041345626115799,
-0.00044670168426819146,
-0.07151476293802261,
-0.005945540964603424,
0.017436273396015167,
-0.07932832092046738,
-0.008274965919554234,
... |
PMID:27892 | [Neurohumoral correlations and the effect of hydrocortisone on respiratory function in experimental pancreatitis]. | From the observations on 18 patients and the experiments on 77 dogs with experimental pancreatitis neuro-humoral interrelations and hydrocortisone effect upon the respiratory function have been studied. Both in the clinic and in the experiment the authors have found the intermediate metabolism disturbed: adrenaline-lik... | [Neurohumoral correlations and the effect of hydrocortisone on respiratory function in experimental pancreatitis]. From the observations on 18 patients and the experiments on 77 dogs with experimental pancreatitis neuro-humoral interrelations and hydrocortisone effect upon the respiratory function have been studied. Bo... | [
-0.036973994225263596,
0.031597916036844254,
-0.0005237364675849676,
0.04677736386656761,
-0.020420830696821213,
-0.003686893731355667,
0.08506849408149719,
0.04735594987869263,
-0.01790107600390911,
-0.02277238853275776,
-0.06600061058998108,
-0.034192271530628204,
0.017358915880322456,
0... |
PMID:27893 | [Comparative assessment of the methods for surgical treatment of cryptorchism]. | The experience with the surgical treatment of 305 cases of cryptorchism is presented. 108 Keetly and Torek's operations and 22 Mixter's operations have proved that in surgical technic the main emphasis should be transferred to the mobilization of the spermatic cord elements, but the orchoifixation should be simple and ... | [Comparative assessment of the methods for surgical treatment of cryptorchism]. The experience with the surgical treatment of 305 cases of cryptorchism is presented. 108 Keetly and Torek's operations and 22 Mixter's operations have proved that in surgical technic the main emphasis should be transferred to the mobilizat... | [
0.028962135314941406,
0.02940145879983902,
0.004290090873837471,
-0.0019447874510660768,
-0.04942403733730316,
0.020647358149290085,
-0.0004057715705130249,
0.05147955194115639,
-0.028866341337561607,
-0.010971910320222378,
0.015897052362561226,
-0.06217263638973236,
0.022918395698070526,
... |
PMID:27895 | [The localisation of endocrine cells in the distal esophagus (author's transl)]. | At the esophago-cardiac junction squamous epithelium is intermingled with gastric epithelium. Within the lamina propria of the distal 3 cm of the esophagus we found cardiac glands with many argyrophil cells in 60% of cases. Electron microscopy revealed seven well knonwn types and two further forms which we could not id... | [The localisation of endocrine cells in the distal esophagus (author's transl)]. At the esophago-cardiac junction squamous epithelium is intermingled with gastric epithelium. Within the lamina propria of the distal 3 cm of the esophagus we found cardiac glands with many argyrophil cells in 60% of cases. Electron micros... | [
0.007564053405076265,
-0.06909515708684921,
0.019344763830304146,
0.05242191627621651,
-0.012159155681729317,
-0.038242705166339874,
0.07970820367336273,
0.02403954602777958,
-0.02878843992948532,
-0.06969553232192993,
-0.027219919487833977,
-0.09149986505508423,
-0.03752005472779274,
0.04... |
PMID:27901 | Maintenance of 2,3-DPG and ATP levels in blood stored for 30 days at a constant pH obtained by variation of CO2. | A novel procedure for storing blood at a controlled pH consists in collecting blood in a pH 8.20, Tris-CPD solution and storing it in a special recipient including a gas permeable membrane under a CO2 atmosphere. The recipient is placed in an atmosphere of variable CO2 content, so that the initial alkalinity of the pre... | Maintenance of 2,3-DPG and ATP levels in blood stored for 30 days at a constant pH obtained by variation of CO2. A novel procedure for storing blood at a controlled pH consists in collecting blood in a pH 8.20, Tris-CPD solution and storing it in a special recipient including a gas permeable membrane under a CO2 atmosp... | [
-0.08623910695314407,
0.031656451523303986,
0.025329072028398514,
0.04449639469385147,
-0.008765785954892635,
-0.03410892188549042,
0.04389343783259392,
0.03605301305651665,
-0.06677974760532379,
0.003120972076430917,
0.04888085275888443,
-0.05295912176370621,
-0.009043101221323013,
0.0489... |
PMID:27903 | Production of valine by a Bacillus sp. | A bacterium isolated from Burdwan (India) soil was found to accumulate L-valine in the growth medium and identified to be a strain of Bacillus subtilis. The strain is able to grow and accumulate valine in a purely synthetic medium, but supplementation of the synthetic medium with either Casamino acids or yeast extract ... | Production of valine by a Bacillus sp. A bacterium isolated from Burdwan (India) soil was found to accumulate L-valine in the growth medium and identified to be a strain of Bacillus subtilis. The strain is able to grow and accumulate valine in a purely synthetic medium, but supplementation of the synthetic medium with ... | [
-0.004177904687821865,
0.03959546983242035,
-0.05827292799949646,
-0.013207871466875076,
0.01812872663140297,
-0.05688130483031273,
-0.01577409729361534,
0.02462509647011757,
-0.07604038715362549,
0.04619322717189789,
0.03012426756322384,
-0.14220531284809113,
0.041123632341623306,
0.04692... |
PMID:27909 | [Circulating immune complexes in acute viral hepatitis, chronic active hepatitis, and periarteritis nodosa (author's transl)]. | Circulating immune complexes were determined in patients with acute viral hepatitis, chronic active hepatitis and periarteriitis nodosa with the Raji cell technique. Circulating immune complexes were found in 11/18 HBsAg positive and HBsAg negative cases of acute viral hepatitis. In HBsAg positive chronic active hepati... | [Circulating immune complexes in acute viral hepatitis, chronic active hepatitis, and periarteritis nodosa (author's transl)]. Circulating immune complexes were determined in patients with acute viral hepatitis, chronic active hepatitis and periarteriitis nodosa with the Raji cell technique. Circulating immune complexe... | [
-0.06410437822341919,
0.04380330443382263,
-0.03771422430872917,
0.0647694393992424,
0.044503793120384216,
-0.052948083728551865,
0.11635813117027283,
0.06676536798477173,
-0.041231341660022736,
0.017172284424304962,
-0.014270631596446037,
-0.12974965572357178,
0.06861589848995209,
0.01807... |
PMID:27927 | [Psychophysiologic characteristics of the individual psychotropic activity of benzodiazepine derivatives under experimental conditions]. | In 156 experiments performed on 41 cats with adequate experimental models of pseudoneurotic conditions, states of anxiety due to an electrostimulation of the hypothalamus through implanted electrodes and an emotional stress due to a conflict situation the authors compared the individual traits of the psychotropic activ... | [Psychophysiologic characteristics of the individual psychotropic activity of benzodiazepine derivatives under experimental conditions]. In 156 experiments performed on 41 cats with adequate experimental models of pseudoneurotic conditions, states of anxiety due to an electrostimulation of the hypothalamus through impl... | [
-0.0000019955487005063333,
0.020226716995239258,
0.04018796980381012,
0.05436165630817413,
-0.003630406456068158,
0.015377895906567574,
0.09765241295099258,
0.009878498502075672,
-0.018135156482458115,
-0.05997082591056824,
-0.04323619604110718,
0.008873178623616695,
-0.021306656301021576,
... |
PMID:27929 | A direct lead technique for histochemical demonstration of leucocyte alkaline phosphatase activity in blood smears. | A histochemical technique for demonstrating leucocyte alkaline phosphatase activity (LAP), based on direct precipitation of lead phosphate at pH 9.5, is described. The effect of fixative, temperature and stability of the medium on the activity of the enzyme and stability of the colour reaction was thoroughly studied. P... | A direct lead technique for histochemical demonstration of leucocyte alkaline phosphatase activity in blood smears. A histochemical technique for demonstrating leucocyte alkaline phosphatase activity (LAP), based on direct precipitation of lead phosphate at pH 9.5, is described. The effect of fixative, temperature and ... | [
-0.0420750230550766,
0.01474067848175764,
0.010569671168923378,
0.00722508504986763,
-0.03134241700172424,
-0.05047595128417015,
0.0810142457485199,
0.06406324356794357,
-0.039240118116140366,
-0.03807450458407402,
-0.008994337171316147,
-0.028779247775673866,
-0.03315889835357666,
0.02945... |
PMID:27930 | Effect of beta-sympatholytic agents on vascular responses to noradrenaline and potassium chloride. | Vasoconstrictory responses to noradrenaline (NA) or high potassium chloride (130 mM) usually show a biphasic behaviour: an initial peak is followed by a lower steady state level. The influence of three beta-sympatholytic agents (propranolol, pindolol, practolol) and a "Ca-antagonist" (verapamil) on this particular beha... | Effect of beta-sympatholytic agents on vascular responses to noradrenaline and potassium chloride. Vasoconstrictory responses to noradrenaline (NA) or high potassium chloride (130 mM) usually show a biphasic behaviour: an initial peak is followed by a lower steady state level. The influence of three beta-sympatholytic ... | [
-0.06056754291057587,
-0.0012676455080509186,
0.004703042097389698,
0.031787190586328506,
0.015517880208790302,
-0.031032076105475426,
0.030128641054034233,
0.023975195363163948,
-0.0024086416233330965,
-0.057654719799757004,
0.03280682861804962,
-0.03895348682999611,
0.004113761242479086,
... |
PMID:27932 | Effects of alpha-adrenergic stimulation and blockade of plasma parathyroid hormone concentrations in cows. | Experiments were designed to investigate responses of immunoreactive parathyroid hormone (PTH) during alpha-adrenergic stimulation and blockade in cows. Alpha-adrenergic agonists (methoxamine, phenylephrine and noradrenaline, the beta-adrenergic action of which was blocked by propranolol) did not change PTH and free fa... | Effects of alpha-adrenergic stimulation and blockade of plasma parathyroid hormone concentrations in cows. Experiments were designed to investigate responses of immunoreactive parathyroid hormone (PTH) during alpha-adrenergic stimulation and blockade in cows. Alpha-adrenergic agonists (methoxamine, phenylephrine and no... | [
0.017326822504401207,
0.018471810966730118,
-0.012419629842042923,
0.09149236977100372,
-0.005664093419909477,
-0.023421788588166237,
0.06263525038957596,
0.03780626878142357,
-0.010295107960700989,
-0.03413398563861847,
0.002061663893982768,
-0.050606243312358856,
0.020196525380015373,
0.... |
PMID:27933 | Testicular blood flow and testosterone concentrations in the spermatic venous blood in rats with experimental cryptorchidism. | Testicular blood flow and testosterone concentrations in the spermatic venous plasma were measured on unilaterally cryptorchid rats. Blood flow to the cryptorchid testis was 31.4 +/- 11.7 (SD) ml/100 g X min which was significantly higher thant that of the scrotal testis (17.7 +/- 4.4 ml/100 g X min). Stereological ana... | Testicular blood flow and testosterone concentrations in the spermatic venous blood in rats with experimental cryptorchidism. Testicular blood flow and testosterone concentrations in the spermatic venous plasma were measured on unilaterally cryptorchid rats. Blood flow to the cryptorchid testis was 31.4 +/- 11.7 (SD) m... | [
0.0497652105987072,
0.013098811730742455,
-0.005052541382610798,
-0.053899623453617096,
0.009449010714888573,
0.026920346543192863,
0.06074361503124237,
0.044831547886133194,
-0.04394852742552757,
-0.013326148502528667,
0.012656579725444317,
-0.08585478365421295,
0.05179373547434807,
0.029... |
PMID:27934 | Erythrocyte acetylcholinesterase activity changes in the early stages of anemic and hypobaric hypoxia or after CoCl2 treatment in rabbits. | The authors studied the changes of erythrocyte acetylcholinesterase (AChE) activity in rabbits respectively subjected to bleeding, hypobaric hypoxia and CoCl2 treatment; in such conditions a rise of the enzyme activity was observed. Similar increases take place also as a consequence of intravenous infusions carried out... | Erythrocyte acetylcholinesterase activity changes in the early stages of anemic and hypobaric hypoxia or after CoCl2 treatment in rabbits. The authors studied the changes of erythrocyte acetylcholinesterase (AChE) activity in rabbits respectively subjected to bleeding, hypobaric hypoxia and CoCl2 treatment; in such con... | [
-0.06377553939819336,
0.011488345451653004,
0.00385987083427608,
0.08776014298200607,
-0.00015345646534115076,
-0.010549499653279781,
0.07939571142196655,
0.04679877683520317,
-0.025295840576291084,
0.00036290299613028765,
-0.0218647588044405,
-0.034012194722890854,
-0.04083608090877533,
-... |
PMID:27935 | The adrenergic mechanism of the haemodynamic effects of massive doses of hydrocortisone in controlled haemorrhagic shock in the dog. | Haemorrhagic shock was induced in anaesthetized dogs by bleeding them into a blood reservoir system. By adjusting the blood level of the reservoir at a certain distance over the heart level the mean arterial blood pressure was kept at 6.7 kPa (50 mmHg). As has been found earlier, massive doses of hydrocortisone (80-560... | The adrenergic mechanism of the haemodynamic effects of massive doses of hydrocortisone in controlled haemorrhagic shock in the dog. Haemorrhagic shock was induced in anaesthetized dogs by bleeding them into a blood reservoir system. By adjusting the blood level of the reservoir at a certain distance over the heart lev... | [
-0.07402139902114868,
0.011101978830993176,
-0.041255563497543335,
0.05315548554062843,
0.010466959327459335,
-0.0381246954202652,
0.03622114658355713,
0.03528769686818123,
0.00027540160226635635,
-0.016986286267638206,
0.024851901456713676,
-0.004647599533200264,
-0.010951434262096882,
0.... |
PMID:27936 | Neuromuscular blockade of fazadinium bromide (AH 8165) in renal failure patients. | Fazadinium bromide (AH 8165) is a new non-depolarizing neuromuscular blocking agent with rapid onset of action and intermediate duration of effect. The characteristics of the neuromuscular blockade induced were compared in normal and renal failure patients by monitoring the mechanical responses of thumb adductor muscle... | Neuromuscular blockade of fazadinium bromide (AH 8165) in renal failure patients. Fazadinium bromide (AH 8165) is a new non-depolarizing neuromuscular blocking agent with rapid onset of action and intermediate duration of effect. The characteristics of the neuromuscular blockade induced were compared in normal and rena... | [
-0.04121697321534157,
-0.02157018706202507,
-0.0017564924200996757,
0.04194455221295357,
-0.029167046770453453,
0.024045782163739204,
0.016444679349660873,
0.04936162754893303,
-0.056162185966968536,
-0.04201227053999901,
-0.016216415911912918,
-0.0618571937084198,
0.00126655085477978,
0.0... |
PMID:27937 | Cerebral metabolic rate of oxygen (CMRO2) in the acute phase of brain injury. | In 22 comatose patients with acute brain injury, the cerebral metabolic rate of oxygen (CMRO2) was calculated as the product of the hemispheric cerebral blood flow (CBF) and the arteriovenous oxygen content difference. All patients were subjected to moderate sedation without barbiturates, normothermia and respiratory t... | Cerebral metabolic rate of oxygen (CMRO2) in the acute phase of brain injury. In 22 comatose patients with acute brain injury, the cerebral metabolic rate of oxygen (CMRO2) was calculated as the product of the hemispheric cerebral blood flow (CBF) and the arteriovenous oxygen content difference. All patients were subje... | [
-0.08565430343151093,
0.01033294852823019,
-0.040262557566165924,
-0.01054867822676897,
0.01770005188882351,
0.04644698649644852,
0.059835806488990784,
0.04720607027411461,
0.022977638989686966,
0.012279202230274677,
-0.012647997587919235,
-0.04957514628767967,
0.019534144550561905,
0.0239... |
PMID:27938 | Cerebral autoregulation in unconscious patients with brain injury. | In 18 unconscious patients with traumatic brain injury, the cerebral autoregulation was tested during the first 2-3 weeks after the acute trauma. Regional cerebral blood flow (rCBF) was measured by the intra-arterial 133xenon washout method before and after an increase of about 20% in the mean arterial blood pressure (... | Cerebral autoregulation in unconscious patients with brain injury. In 18 unconscious patients with traumatic brain injury, the cerebral autoregulation was tested during the first 2-3 weeks after the acute trauma. Regional cerebral blood flow (rCBF) was measured by the intra-arterial 133xenon washout method before and a... | [
-0.08125881105661392,
0.0019916389137506485,
-0.013939536176621914,
-0.003752193646505475,
0.014282897114753723,
0.06348507106304169,
0.12388560175895691,
0.022281544283032417,
-0.008510217070579529,
-0.059949200600385666,
0.008315932005643845,
-0.009156986139714718,
-0.025162460282444954,
... |
PMID:27939 | Haemodynamic effects of different corticosteroids in controlled haemorrhagic shock in the dog. | The haemodynamic effects of massive doses of hydrocortisone (80-320 mg.kg-1), methylprednisolone (4-32 mg.kg-1), betamethasone (1.6-12.8 mg.kg-1) and aldosterone (0.1-0.8 mg.kg-1) and the interaction with phenoxybenzamine and propranolol have been studied during controlled haemorrhagic shock in the anaesthetized dog. H... | Haemodynamic effects of different corticosteroids in controlled haemorrhagic shock in the dog. The haemodynamic effects of massive doses of hydrocortisone (80-320 mg.kg-1), methylprednisolone (4-32 mg.kg-1), betamethasone (1.6-12.8 mg.kg-1) and aldosterone (0.1-0.8 mg.kg-1) and the interaction with phenoxybenzamine and... | [
-0.0792396068572998,
0.030162278562784195,
-0.018051108345389366,
0.0521872378885746,
0.008020206354558468,
-0.008395914919674397,
0.016386205330491066,
0.007625564932823181,
0.0008886889554560184,
-0.030325595289468765,
-0.03156518191099167,
-0.029154567047953606,
0.016899866983294487,
0.... |
PMID:27942 | Effects of isoprenaline and dibutyryl-C-AMP on the electrical and mechanical activity of the rabbit myometrium. | Mechanical and electrical responses of spontaneously contracting muscle strips from oestrogen dominated rabbit uterus were investigated by the sucrose gap method. The effects of isoprenaline and dibutyryl-c-AMP in the presence and absence of propranolol were tested. It has been shown previously that the beta-adrenocept... | Effects of isoprenaline and dibutyryl-C-AMP on the electrical and mechanical activity of the rabbit myometrium. Mechanical and electrical responses of spontaneously contracting muscle strips from oestrogen dominated rabbit uterus were investigated by the sucrose gap method. The effects of isoprenaline and dibutyryl-c-A... | [
-0.05808335170149803,
-0.05319824442267418,
-0.008353482000529766,
0.0535946749150753,
0.0334920771420002,
0.018048325553536415,
-0.011513813398778439,
0.020141541957855225,
-0.03933893144130707,
-0.04116658866405487,
0.0052834548987448215,
-0.017588766291737556,
-0.02259739674627781,
0.04... |
PMID:27945 | The release of serotonin from rat duodenal enterochromaffin cells by adrenoceptor agonists studied in vitro. | The serotonin (5-HT) content of enterochromaffin cells (EC) was studied by a cytofluorimetric method in biopsies from rat duodenal mucosa after in vitro incubation with different adrenoceptor agonists and antagonists and acetylcholine (ACh). Noradrenaline (NA), Adrenaline (A) and Isoprenaline (IP) caused a decrease of ... | The release of serotonin from rat duodenal enterochromaffin cells by adrenoceptor agonists studied in vitro. The serotonin (5-HT) content of enterochromaffin cells (EC) was studied by a cytofluorimetric method in biopsies from rat duodenal mucosa after in vitro incubation with different adrenoceptor agonists and antago... | [
-0.026019951328635216,
-0.008075683377683163,
-0.008361178450286388,
0.03186255693435669,
-0.034265000373125076,
-0.032754190266132355,
0.046213652938604355,
0.03563738241791725,
-0.04397755488753319,
-0.11345391720533371,
0.027136100456118584,
-0.032701276242733,
-0.01963571272790432,
0.0... |
PMID:27948 | Comparative evaluation of hypnotic efficacy of flunitrazepam in psychiatric in-patients. | Flunitrazepam in 2-mg and 4-mg doses was compared with flurazepam 30 mg and nitrazepam 10 mg for hypnotic efficacy in a double-blind, multiple cross-over trial involving 41 psychiatric in-patients. In the vast majority of comparisons involving a number of sleep parameters differences did not reach significance level. F... | Comparative evaluation of hypnotic efficacy of flunitrazepam in psychiatric in-patients. Flunitrazepam in 2-mg and 4-mg doses was compared with flurazepam 30 mg and nitrazepam 10 mg for hypnotic efficacy in a double-blind, multiple cross-over trial involving 41 psychiatric in-patients. In the vast majority of compariso... | [
-0.0003133474965579808,
0.004278900567442179,
-0.022534219548106194,
0.04271399974822998,
0.02525309845805168,
0.06074320524930954,
0.07031315565109253,
0.04657643288373947,
0.008145599626004696,
-0.09629444777965546,
-0.016567567363381386,
-0.004430006258189678,
0.02077358216047287,
-0.02... |
PMID:27949 | Neuroendocrine disorders in depressions and their significance for the monoamine hypothesis of depression. | This article discusses the results of recent neuroendocrinological research in depressions. The abnormalities found in a given category of vital depressive patients--cortisol hypersecretion, decreased growth hormone response to insulin hypoglycaemia and decreased luteinizing hormone secretion in menopause--are believed... | Neuroendocrine disorders in depressions and their significance for the monoamine hypothesis of depression. This article discusses the results of recent neuroendocrinological research in depressions. The abnormalities found in a given category of vital depressive patients--cortisol hypersecretion, decreased growth hormo... | [
0.013946975581347942,
0.024597328156232834,
-0.004963170737028122,
0.06108983978629112,
-0.029437871649861336,
0.04239531233906746,
0.12172883749008179,
0.020948117598891258,
0.019302643835544586,
-0.05188653990626335,
-0.01726587861776352,
-0.03550407290458679,
0.010541534051299095,
0.084... |
PMID:27950 | Primary culture of adult rat liver cells. III. Hormonal effects on cytological and biochemical properties of primary cultured cells. | The effect of various hormones on cytological and biochemical properties of cultured hepatic cells were investigated in order to obtain long-term survival of the hepatocytes with adult liver functions in primary culture. Insulin supplementation of the culture medium enhanced the attachemnt efficiency of cells in primar... | Primary culture of adult rat liver cells. III. Hormonal effects on cytological and biochemical properties of primary cultured cells. The effect of various hormones on cytological and biochemical properties of cultured hepatic cells were investigated in order to obtain long-term survival of the hepatocytes with adult li... | [
0.02361629530787468,
-0.006013466976583004,
0.03375126048922539,
-0.008387980982661247,
0.009865137748420238,
-0.0037872421089559793,
0.06612589210271835,
0.02056606113910675,
-0.05572175607085228,
-0.015069816261529922,
0.04166358336806297,
-0.004527886863797903,
0.02334524504840374,
0.04... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.