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PMID:27946 | [Actual knowledge on beta blocking agents in psychiatry (author's transl)]. | A new group of substances blocking central beta receptors, ie beta blocking agents among which oxprenol and pindolol, have been used in psychiatry, mainly in anxious or depressive-anxious patients. The anxiolytic effect, particularly on somatic anxiety, is interesting, and is present in double blind studies with benzod... | [Actual knowledge on beta blocking agents in psychiatry (author's transl)]. A new group of substances blocking central beta receptors, ie beta blocking agents among which oxprenol and pindolol, have been used in psychiatry, mainly in anxious or depressive-anxious patients. The anxiolytic effect, particularly on somatic... | [
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PMID:27953 | Resonance Raman studies on the ligand-iron interactions in hemoproteins and metallo-porphyrins. | The resonance Raman spectra (RRS) were measured for various hemoproteins, as well as for free hemes, and analysed in terms of the interactions between the porphyrin ring and the heme iron and between the axial ligand and the heme iron. To establish vibrational assignments, the RRS of metallo-octae-thylporphyrin (M(OEP)... | Resonance Raman studies on the ligand-iron interactions in hemoproteins and metallo-porphyrins. The resonance Raman spectra (RRS) were measured for various hemoproteins, as well as for free hemes, and analysed in terms of the interactions between the porphyrin ring and the heme iron and between the axial ligand and the... | [
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PMID:27947 | [Flunitrazepam and memory (author's transl)]. | This work is based on the observation of memory troubles before sleep in patients with sleep problems treated with flunitrazepam. Eight subjects are tested in two sessions, flunitrazepam and placebo, in double blind, with memory tests given the evening after medication and controlled the next morning. One additional te... | [Flunitrazepam and memory (author's transl)]. This work is based on the observation of memory troubles before sleep in patients with sleep problems treated with flunitrazepam. Eight subjects are tested in two sessions, flunitrazepam and placebo, in double blind, with memory tests given the evening after medication and ... | [
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PMID:27954 | Nuclear magnetic resonance studies of high-spin ferric hemoproteins. | 220 MHz proton Fourier transform (FT) NMR with quadrature phase detection (QPD) technique is applied to observe largely hyperfine-shifted signals of various hemoproteins and hemoenzymes in ferric high-spin state. The binding of F-, OCN-, SCN-, and CH3OH to the ferric heme iron in high-spin state in various hemoproteins... | Nuclear magnetic resonance studies of high-spin ferric hemoproteins. 220 MHz proton Fourier transform (FT) NMR with quadrature phase detection (QPD) technique is applied to observe largely hyperfine-shifted signals of various hemoproteins and hemoenzymes in ferric high-spin state. The binding of F-, OCN-, SCN-, and CH3... | [
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PMID:27955 | Analysis of acid-base properties of peroxidase and myoglobin. | Two heme-linked groups of horseradish peroxidases, characterized by pKa = 5.8 (isoenzyme A) and 7.3 (isoenzyme C), are believed to be distal amino acid residues and, judging by their acid-base properties in various derivatives, influence the functions of these isoenzymes. In contrast, in myoglobin ionization of the dis... | Analysis of acid-base properties of peroxidase and myoglobin. Two heme-linked groups of horseradish peroxidases, characterized by pKa = 5.8 (isoenzyme A) and 7.3 (isoenzyme C), are believed to be distal amino acid residues and, judging by their acid-base properties in various derivatives, influence the functions of the... | [
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PMID:27956 | Conformational change and cooperative ligand binding in hemoglobin. | Although many studies have been carried out on the cooperativityly of ligand binding to hemoglobin, its molecular mechanism is not yet completely confirmed. Various models have been proposed on one hand, but on the other hand the direct judgement of the validity of each model is confronted with experimental difficultie... | Conformational change and cooperative ligand binding in hemoglobin. Although many studies have been carried out on the cooperativityly of ligand binding to hemoglobin, its molecular mechanism is not yet completely confirmed. Various models have been proposed on one hand, but on the other hand the direct judgement of th... | [
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PMID:27964 | The effect of inhibitors of cellular RNA synthesis on stimulation of mouse encephalomyocarditis virus reproduction by poliovirus in HeLa and MIO cells. | Inoculation of HeLa and MIO cells with a guanidine-dependent mutant of poliovirus (gd-polio) in the absence of guanidine resulted in stimulation of mouse encephalomyocarditis (EMC) virus reproduction. No stimulation was found to occur in the presence of actinomycin D, on pre-treatment of the cells with cordycepin, or o... | The effect of inhibitors of cellular RNA synthesis on stimulation of mouse encephalomyocarditis virus reproduction by poliovirus in HeLa and MIO cells. Inoculation of HeLa and MIO cells with a guanidine-dependent mutant of poliovirus (gd-polio) in the absence of guanidine resulted in stimulation of mouse encephalomyoca... | [
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PMID:27965 | Marked difference in electrophoretic migration rates between two influenza A viruses. | Comparative moving boundary electrophoresis revealed that influenza virus A/PR/8/34 (H0N1) has a 2.5 times higher electrophoretic migration rate at pH 7 than influenza virus A/Singpore/1/57 (H2N2). This difference was the same whether the compared viruses were purified first by either ammonium sulphate precipitation or... | Marked difference in electrophoretic migration rates between two influenza A viruses. Comparative moving boundary electrophoresis revealed that influenza virus A/PR/8/34 (H0N1) has a 2.5 times higher electrophoretic migration rate at pH 7 than influenza virus A/Singpore/1/57 (H2N2). This difference was the same whether... | [
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PMID:27966 | Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMRI and C57/BL mice. | The multiplication of 8 strains of herpes simplex virus of type 1 and 2 in normal and stimulated macrophages of NMRI and C57/bl mice was tested. Only 3 strains multiplied in normal NMRI macrophages, whereas all strains multiplied in stimulated cells. No multiplication except of one strain was observed in C57/bl macroph... | Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMRI and C57/BL mice. The multiplication of 8 strains of herpes simplex virus of type 1 and 2 in normal and stimulated macrophages of NMRI and C57/bl mice was tested. Only 3 strains multiplied in normal NMRI macrophages, whereas all strains multipli... | [
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PMID:27967 | Haemagglutination inhibition antibodies in nasal secretions of persons after natural parainfluenza virus infection. | In 7 adults and 7 children with upper respiratory illness of parainfluenza aetiology, the virus was isolated in the acute phase from nasal washings or nasal smears in spite of high titres of haemagglutination inhibition (HI) antibodies in serum. By contrast, secretory HI antibodies were not demonstrated at the onset of... | Haemagglutination inhibition antibodies in nasal secretions of persons after natural parainfluenza virus infection. In 7 adults and 7 children with upper respiratory illness of parainfluenza aetiology, the virus was isolated in the acute phase from nasal washings or nasal smears in spite of high titres of haemagglutina... | [
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PMID:27968 | Cell- and antibody-mediated responses to measles and mumps viruses in experimental animals. | Monkeys and guinea pigs were immunized with various doses of measles and mumps viruses. A cell-mediated response measured by leukocyte migration inhibition occured during the first two weeks after immunization. In case of measles virus, marked migration inhibition occurred already on the 7th day in monkeys and guinea p... | Cell- and antibody-mediated responses to measles and mumps viruses in experimental animals. Monkeys and guinea pigs were immunized with various doses of measles and mumps viruses. A cell-mediated response measured by leukocyte migration inhibition occured during the first two weeks after immunization. In case of measle... | [
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PMID:27969 | Morphological characteristics of the infection of animals with tick-borne encephalitis virus persisting for a long time in cell cultures. | The pathogenicity of the Soph-K strain of tick-borne encephalitis (TBE) virus produced by the persistently infected HEp-2-Soph cell culture was investigated in monkeys, white mice and hamsters. The persistent infection of this culture with TBE virus has been maintained for 17 years. The Soph-K strain was shown to retai... | Morphological characteristics of the infection of animals with tick-borne encephalitis virus persisting for a long time in cell cultures. The pathogenicity of the Soph-K strain of tick-borne encephalitis (TBE) virus produced by the persistently infected HEp-2-Soph cell culture was investigated in monkeys, white mice an... | [
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PMID:27970 | Sepcific immunofluorescent IgG, IgM, and IgA antibodies in lymphocytic choriomeningitis. | In postnatally acquired lymphocytic choriomeningitis (LCM), specific immunofluorescent (IF) IgM antibody was found nearly in all the examined sera from 23 patients for 6-8 months after onset of the disease, IgA antibody in two-thirds of the patients and only during the first 5 weeks of the disease. In the first weeks, ... | Sepcific immunofluorescent IgG, IgM, and IgA antibodies in lymphocytic choriomeningitis. In postnatally acquired lymphocytic choriomeningitis (LCM), specific immunofluorescent (IF) IgM antibody was found nearly in all the examined sera from 23 patients for 6-8 months after onset of the disease, IgA antibody in two-thir... | [
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PMID:27972 | Accurate determination of volumes injected intracerebrally into suckling mice. | Inoculum with 125I added as a marker was used to determine the volume actually administered to suckling mice on intracerebral (i.c.) inoculation. In 1-2 days old animals, this volume corresponded to approximately 75% of a 20 microliter dose. | Accurate determination of volumes injected intracerebrally into suckling mice. Inoculum with 125I added as a marker was used to determine the volume actually administered to suckling mice on intracerebral (i.c.) inoculation. In 1-2 days old animals, this volume corresponded to approximately 75% of a 20 microliter dose. | [
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PMID:27973 | Effect of interferon and poly I:C on replication of influenza virus in organ cultures of human origin. | Interferon and poly I : C inhibited the growth of influenza virus in organ cultures of foetal nasal mucosa, trachea, oesophagus and adult nasal mucosa. No antiviral effect was observed in decidua organ cultures. The combined use of interferon and poly I : C resulted in the enhancement of the antiviral effect. | Effect of interferon and poly I:C on replication of influenza virus in organ cultures of human origin. Interferon and poly I : C inhibited the growth of influenza virus in organ cultures of foetal nasal mucosa, trachea, oesophagus and adult nasal mucosa. No antiviral effect was observed in decidua organ cultures. The c... | [
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PMID:27974 | Quantitative immunoelectrophoresis of human interferon. A new approach to characterization of interferon preparations. | The electroimmunoassay (quantitative "rocket" immunoelectrophoresis) method was adopted for analysis and characterization of interferon preparations. Ammonium sulphate-precipitated anti-interferon globulin also containing unknown antibodies against antigens that contaminate interferon preparations was used in the tests... | Quantitative immunoelectrophoresis of human interferon. A new approach to characterization of interferon preparations. The electroimmunoassay (quantitative "rocket" immunoelectrophoresis) method was adopted for analysis and characterization of interferon preparations. Ammonium sulphate-precipitated anti-interferon glob... | [
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PMID:27975 | Transmission of Kyasanur Forest disease virus by Rhipicephalus haemaphysaloides ticks. | Larvae of Rhipicephalus haemaphysaloides were infected with Kaysanur Forest disease (KFD) virus by feeding on viraemic rodents and reared into next generation larvae. Fed larvae, nymphs, unfed adults, fed adult males, and females after oviposition were found infected, while the larvae were found free from infection. Ny... | Transmission of Kyasanur Forest disease virus by Rhipicephalus haemaphysaloides ticks. Larvae of Rhipicephalus haemaphysaloides were infected with Kaysanur Forest disease (KFD) virus by feeding on viraemic rodents and reared into next generation larvae. Fed larvae, nymphs, unfed adults, fed adult males, and females aft... | [
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PMID:27976 | Failure of 5-bromodeoxyuridine to influence the activation of latent herpex simplex virus infection in explants of the rabbit regional sensory ganglia. | The occurence of virus-specific antigens in explants of the Gasserian ganglia of rabbits with healed keratitis induced by the Kupka strain of human herpesvirus type 1 was tested by indirect immunofluorescence. In explants, the neurons and satellite cells revealed specific fluorescence from the 3rd day of culturing. The... | Failure of 5-bromodeoxyuridine to influence the activation of latent herpex simplex virus infection in explants of the rabbit regional sensory ganglia. The occurence of virus-specific antigens in explants of the Gasserian ganglia of rabbits with healed keratitis induced by the Kupka strain of human herpesvirus type 1 w... | [
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PMID:27977 | Khasan virus, a new ungrouped bunyavirus isolated from Haemaphysalis longicornis ticks in the Primorie region. | Strain LEIV-776P, possessing no haemagglutinating activity was isolated in 1971 in the Primorie region (U.S.S.R.) from Haemaphysalis longicornis Neumann 1091 tick. Complement fixation (CF) tests revealed no antigenic relationship with 24 antigenic groups of arboviruses or 21 ungrouped viruses isolated from ticks. The v... | Khasan virus, a new ungrouped bunyavirus isolated from Haemaphysalis longicornis ticks in the Primorie region. Strain LEIV-776P, possessing no haemagglutinating activity was isolated in 1971 in the Primorie region (U.S.S.R.) from Haemaphysalis longicornis Neumann 1091 tick. Complement fixation (CF) tests revealed no an... | [
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PMID:27980 | Correlation between foetal pH, cord blood glucose level and Apgar score in a foetal intensive care unit--preliminary report. | The foetal pH (the term 'foetal pH' is used for the pH of foetal capillary blood obtained by making a small incision in the foetal scalp or buttocks) and the umbilical cord blood glucose levels in pregnant women with foetal distress were estimated in 19 babies as a prospective study in Ile-Ife, Nigeria. The Apgar Score... | Correlation between foetal pH, cord blood glucose level and Apgar score in a foetal intensive care unit--preliminary report. The foetal pH (the term 'foetal pH' is used for the pH of foetal capillary blood obtained by making a small incision in the foetal scalp or buttocks) and the umbilical cord blood glucose levels i... | [
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PMID:27982 | Adjunctive drug use by methadone patients. | Clinical impressions, reinforced by reports in both professional journals and the lay press, suggested that use and abuse of minor tranquilizers and sedative-hypnotics was extensive among patients in our drug treatment clinics and required some change in our policies. We surveyed a randomly selected national sample of ... | Adjunctive drug use by methadone patients. Clinical impressions, reinforced by reports in both professional journals and the lay press, suggested that use and abuse of minor tranquilizers and sedative-hypnotics was extensive among patients in our drug treatment clinics and required some change in our policies. We surve... | [
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PMID:27983 | Esophageal epithelial response to gastroesophageal reflux. A quantitative study. | Exposure of the distal esophageal mucosa to acid gastric juice was quantitated by 24-hr pH monitoring in 100 individuals and was correlated with morphologic data derived from esophageal biopsies. The degree of acid exposure to the distal esophagus correlated directly with increases in both relative and absolute length ... | Esophageal epithelial response to gastroesophageal reflux. A quantitative study. Exposure of the distal esophageal mucosa to acid gastric juice was quantitated by 24-hr pH monitoring in 100 individuals and was correlated with morphologic data derived from esophageal biopsies. The degree of acid exposure to the distal e... | [
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PMID:27984 | NADPH-oxidation activities in subcellular fractions isolated from resting or phagocytozing human polymorphonuclears. | Using a fluorometric assay for the determination of oxidized pyridine nucleotides (NAD[P]+), total and cyanide-resistant NADPH-oxidative activities have been measured in subcellular fractions isolated from resting and phagocytosing human polymorphonuclears. Enzymatic activies responsible for the oxidation of the NADPH ... | NADPH-oxidation activities in subcellular fractions isolated from resting or phagocytozing human polymorphonuclears. Using a fluorometric assay for the determination of oxidized pyridine nucleotides (NAD[P]+), total and cyanide-resistant NADPH-oxidative activities have been measured in subcellular fractions isolated fr... | [
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PMID:27985 | Presence of arylsulfatase A (ARS A) in multiple sulfatase deficiency disorder fibroblasts. | Multiple deficiency disorder fibroblasts cultured in MEM-CO2 showed deficiencies of arylsulfatase A(ARS A) comparable to the deficiency in metachromatic leukodystrophy fibroblasts. However, the MSDD fibroblasts cultured in MEM-HEPES contained near normal levels of ARS A. Moreover, the enzyme from the latter fibroblasts... | Presence of arylsulfatase A (ARS A) in multiple sulfatase deficiency disorder fibroblasts. Multiple deficiency disorder fibroblasts cultured in MEM-CO2 showed deficiencies of arylsulfatase A(ARS A) comparable to the deficiency in metachromatic leukodystrophy fibroblasts. However, the MSDD fibroblasts cultured in MEM-HE... | [
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PMID:27986 | Renal response of fetal lamb to complete occlusion of umbilical cord. | The renal response of the fetal lamb to repeated complete occlusion of the umbilical cord was studied in nine chronically instrumented animals. Five episodes of occlusion of the umbilical cord, each lasting for two minutes, produced a twofold rise in fetal urine osmolality and sodium, chloride, and potassium concentrat... | Renal response of fetal lamb to complete occlusion of umbilical cord. The renal response of the fetal lamb to repeated complete occlusion of the umbilical cord was studied in nine chronically instrumented animals. Five episodes of occlusion of the umbilical cord, each lasting for two minutes, produced a twofold rise in... | [
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PMID:27988 | Effects of pH, Ca, ADH, and theophylline on kinetics of Na entry in frog skin. | The short circuit current as a function of Na concentration in both solutions was found to obey Michaelis-Menten kinetics under a variety of experimental conditions. Values of maximal transport rate (Im) and half-maximal Na concentrations (Kt) were determined from these experiments. Three type of results were obtained:... | Effects of pH, Ca, ADH, and theophylline on kinetics of Na entry in frog skin. The short circuit current as a function of Na concentration in both solutions was found to obey Michaelis-Menten kinetics under a variety of experimental conditions. Values of maximal transport rate (Im) and half-maximal Na concentrations (K... | [
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PMID:27989 | Intracellular pH transients in rat diaphragm muscle measured with DMO. | Changes of the intracellular pH of rat diaphragm muscle were monitored at 30-min intervals with the weak acid DMO (5,5-dimethyl-2,4-oxazolidinedione). Transferring the muscle from a CO2-containing to a CO2-free solution caused intracellular pH (pHi) to rise by an average of 0.18 during the first 30 min and then to leve... | Intracellular pH transients in rat diaphragm muscle measured with DMO. Changes of the intracellular pH of rat diaphragm muscle were monitored at 30-min intervals with the weak acid DMO (5,5-dimethyl-2,4-oxazolidinedione). Transferring the muscle from a CO2-containing to a CO2-free solution caused intracellular pH (pHi)... | [
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PMID:27990 | Infection rates of Aedes triseriatus following ingestion of La Crosse virus by the larvae. | Infection rates ranged from 0-2.1% in adults of Aedes triseriaus reared from groups of larvae that had ingested La Crosse (LAC) virus (Clifornia encephalitis group) at dosages of 7.0-8.3 log 10 SMICLD50/ml. Females form orally infected larvae transmitted the virus to suckling mice. Larvae that devoured carcasses of tra... | Infection rates of Aedes triseriatus following ingestion of La Crosse virus by the larvae. Infection rates ranged from 0-2.1% in adults of Aedes triseriaus reared from groups of larvae that had ingested La Crosse (LAC) virus (Clifornia encephalitis group) at dosages of 7.0-8.3 log 10 SMICLD50/ml. Females form orally in... | [
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PMID:27993 | [Effects of diazepam and flunitrazepam on the undesired postoperative side-effects of ketamine anaesthesia (author's transl)]. | 150 patients undergoing minor gynaecological procedures (curretages) were anesthetized with ketamine and either diazepam flunitrazepam or placebo in order to establish the best combination for the prevention of postoperative psychotomimetic effects. From observations, up to 24 h after operation, it was found and statis... | [Effects of diazepam and flunitrazepam on the undesired postoperative side-effects of ketamine anaesthesia (author's transl)]. 150 patients undergoing minor gynaecological procedures (curretages) were anesthetized with ketamine and either diazepam flunitrazepam or placebo in order to establish the best combination for ... | [
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PMID:28036 | [The use of naloxone in neuroleptoanalgesia]. | Naloxone was used in 20 patients divided into two series: series A consisted of 10 adults with an average age of 50.6 years (+/- 12.03) and series B 10 children with an average age of 8.5 years (+/- 5.16). Naloxone was given in the treatment of postoperative respiratory depression related to persistence of morphine imp... | [The use of naloxone in neuroleptoanalgesia]. Naloxone was used in 20 patients divided into two series: series A consisted of 10 adults with an average age of 50.6 years (+/- 12.03) and series B 10 children with an average age of 8.5 years (+/- 5.16). Naloxone was given in the treatment of postoperative respiratory dep... | [
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PMID:28037 | [Antagonistic effects of naloxone against morphinomimetic agents. Apropos of 10 cases in gynecologic surgery]. | The object of this study was the use of naloxone to correct hypoventilation related to the use of morphinomimetics without suppressing the analgesic effect of these agents. The study involved ten patients undergoing gynaecological surgery under neuroleptanalgesia and who at the end of surgery had hypoventilation due to... | [Antagonistic effects of naloxone against morphinomimetic agents. Apropos of 10 cases in gynecologic surgery]. The object of this study was the use of naloxone to correct hypoventilation related to the use of morphinomimetics without suppressing the analgesic effect of these agents. The study involved ten patients unde... | [
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PMID:28039 | [Electrophysiologic aspects of the effects of etomidate in man]. | Recordings were electroencephalographical (EEG with spectral analysis), polygraphical (EMG, EKG, breathing). Visual and Auditory Cerebral Evoked Responses were also recorded. The depth of narcosis was quantified upon EEG data. The reactivity during the narcosis and the mechanisms of action of Etomidate on the "non spec... | [Electrophysiologic aspects of the effects of etomidate in man]. Recordings were electroencephalographical (EEG with spectral analysis), polygraphical (EMG, EKG, breathing). Visual and Auditory Cerebral Evoked Responses were also recorded. The depth of narcosis was quantified upon EEG data. The reactivity during the na... | [
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PMID:28040 | [Effect of etomidate on cerebral blood flow and oxygen metabolism in man]. | The effects of Etomidate on cerebral blood flow (C.B.F.) and cerebral oxygen consumption (C.02 C.) were studied in 13 patients in a neuroradiology department. Induction of anaesthesia was ensured using a standard dose of 15 mg of Etomidate, followed by a constant rate infusion (2.8 mg/kg/hour). Seven subjects were cons... | [Effect of etomidate on cerebral blood flow and oxygen metabolism in man]. The effects of Etomidate on cerebral blood flow (C.B.F.) and cerebral oxygen consumption (C.02 C.) were studied in 13 patients in a neuroradiology department. Induction of anaesthesia was ensured using a standard dose of 15 mg of Etomidate, foll... | [
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PMID:28041 | [Hemodynamic effects of etomidate]. | A study of the haemodynamic effects of an injection of 0.3 mg/kg of Etomidate was carried out in 11 multiple trauma patients under constant controlled ventilation. At the 3 rd minute after injection there was a slight, but significant, increase in cardiac output and in the systolic index of the left ventricle, persisti... | [Hemodynamic effects of etomidate]. A study of the haemodynamic effects of an injection of 0.3 mg/kg of Etomidate was carried out in 11 multiple trauma patients under constant controlled ventilation. At the 3 rd minute after injection there was a slight, but significant, increase in cardiac output and in the systolic i... | [
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PMID:28042 | [Constant flow anesthesia using a combination of etomidate and fentanyl]. | In 35 orthopaedic surgery patients (33 adults and 2 children), anaesthesia was obtained using an association of etomidate and fentanyl. Induction was obtained by injection from a syringe of a mixture of etomidate and fentanyl in an average dose of 21 mg for etomidate and 0,08 mg for fentanyl. Anaesthesia was maintained... | [Constant flow anesthesia using a combination of etomidate and fentanyl]. In 35 orthopaedic surgery patients (33 adults and 2 children), anaesthesia was obtained using an association of etomidate and fentanyl. Induction was obtained by injection from a syringe of a mixture of etomidate and fentanyl in an average dose o... | [
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PMID:28045 | [Choice of a local anesthetic in obstetrical analgesia]. | A local anaesthetic may be selected from amongst the two major groups of drugs of this type: amino-alcoyl-esters and amino-acylamides. In practice, three substances are available or will shortly be available in France: lignocaine, etidocaine and bupivacaine, thus limiting the choice. This choice is guided by the toxici... | [Choice of a local anesthetic in obstetrical analgesia]. A local anaesthetic may be selected from amongst the two major groups of drugs of this type: amino-alcoyl-esters and amino-acylamides. In practice, three substances are available or will shortly be available in France: lignocaine, etidocaine and bupivacaine, thus... | [
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PMID:28046 | [Effects of peridural analgesia on labor]. | A review of the effects during labour of epidural analgesia on dilatation, expulsion and delivery of the placenta. Uncertainties in knowledge of the precise organisation of uterine innervation and of the intrinsic innervation of the organ render the study of changes in uterine contraction and in cervical resistances di... | [Effects of peridural analgesia on labor]. A review of the effects during labour of epidural analgesia on dilatation, expulsion and delivery of the placenta. Uncertainties in knowledge of the precise organisation of uterine innervation and of the intrinsic innervation of the organ render the study of changes in uterine... | [
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PMID:28048 | [The use of Marcaine in obstetrical analgesia]. | Bupivacaine (Marcaine) is being used increasingly in obstetrics for epidural analgesia, by virtue of the good sensory block obtained and the minimum of side-effects on the mother and newborn infant. At a concentration of less than 0.5 p. 100, analgesia is excellent with a minimal effect on motor fibres. Side-effects an... | [The use of Marcaine in obstetrical analgesia]. Bupivacaine (Marcaine) is being used increasingly in obstetrics for epidural analgesia, by virtue of the good sensory block obtained and the minimum of side-effects on the mother and newborn infant. At a concentration of less than 0.5 p. 100, analgesia is excellent with a... | [
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PMID:28049 | [Experience of labor and obstetrical analgesia]. | A prospective study was undertaken at Strasbourg of the assessment of the patients of the techniques used by the obstetric team and of the general atmosphere in which labour and delivery took place. A questionnair of 115 items was analysed by computer using a Pastis-Pascal programme (see attached). The first results, c... | [Experience of labor and obstetrical analgesia]. A prospective study was undertaken at Strasbourg of the assessment of the patients of the techniques used by the obstetric team and of the general atmosphere in which labour and delivery took place. A questionnair of 115 items was analysed by computer using a Pastis-Pasc... | [
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PMID:28050 | [The organization of an obstetric center in relation to obstetrical analgesia]. | In order that continous epidural anaesthesia may be given safely in an obstetric centre, the permanent presence of an anaesthetist is necessary. Obstetricians and midwives must be familiar with the management of labour using this method and team spirit involving continous cooperation between the anaesthetist, obstetric... | [The organization of an obstetric center in relation to obstetrical analgesia]. In order that continous epidural anaesthesia may be given safely in an obstetric centre, the permanent presence of an anaesthetist is necessary. Obstetricians and midwives must be familiar with the management of labour using this method and... | [
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PMID:28051 | [Economic and social problems posed by peridural anesthesia and obstetrical analgesia]. | It is impossible not to note the small number of epidural anaesthetics given for obstetrics in France. The rarity of centres where it is offered by a team of specially trained anaesthetists and obstetricians contrasts with the increase in demand from the patients themselves. Study of the number of epidural anaesthetics... | [Economic and social problems posed by peridural anesthesia and obstetrical analgesia]. It is impossible not to note the small number of epidural anaesthetics given for obstetrics in France. The rarity of centres where it is offered by a team of specially trained anaesthetists and obstetricians contrasts with the incre... | [
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PMID:28052 | [Study of a new respiratory analeptic: injectable almatrine. Apropos of 22 cases of acute hypoventilation: respiratory activity and electroencephalographic control]. | 2620 is a respiratory analeptic which acts by stimulation of peripheral chemoreceptors. It was administered intravenously in 22 patients in acute respiratory insufficiency. Doses during the first hour varied between 0.7 and 3 mg/kg. A careful study of the effects on respiration showed a significant increase in minute v... | [Study of a new respiratory analeptic: injectable almatrine. Apropos of 22 cases of acute hypoventilation: respiratory activity and electroencephalographic control]. 2620 is a respiratory analeptic which acts by stimulation of peripheral chemoreceptors. It was administered intravenously in 22 patients in acute respirat... | [
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PMID:28053 | [Apropos of complications following the use of methylmethacrylate. Possible prevention by betamethasone]. | The aim of this study was to determine whether the prior injection of betamethasone was capable of preventing blood pressure changes and the fall in arterial pO2 when following the fixation of total hip protheses with methyl metacrylate. It involved 54 patients in whom systolic, diastolic and mean blood pressure (BP), ... | [Apropos of complications following the use of methylmethacrylate. Possible prevention by betamethasone]. The aim of this study was to determine whether the prior injection of betamethasone was capable of preventing blood pressure changes and the fall in arterial pO2 when following the fixation of total hip protheses w... | [
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PMID:28054 | [Comparative study of venous contamination with low FiO2 and with pure oxygen in disease-induced pulmonary edema]. | A comparative study of the venous contamination (Qs/Qt = (Cc'O2 - CaO2) / (Cc'O2 - C-vO2) under FIO2 = 0.45 - 0.6 and under FIO2 = 1, was realised in 9 patients with lesions of pulmonary oedema. Increasing the FIO2 lead to an increase in the venous contamination three times (average increase was 36 p. 100 of the initia... | [Comparative study of venous contamination with low FiO2 and with pure oxygen in disease-induced pulmonary edema]. A comparative study of the venous contamination (Qs/Qt = (Cc'O2 - CaO2) / (Cc'O2 - C-vO2) under FIO2 = 0.45 - 0.6 and under FIO2 = 1, was realised in 9 patients with lesions of pulmonary oedema. Increasing... | [
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PMID:28055 | [Biological tests as indirect indicators of the activity of drug metabolizing enzymes. Use of glucaric acid and gamma-glutamyltransferase]. | Laboratory tests are increasingly important in the surveillance of drug treatments. People in charge of clinical laboratory science must now become aware of a new development, the use of as indicators of the activity of drug-metabolizing enzymes, especially of the induction of such enzymes. Ideally, the activity of suc... | [Biological tests as indirect indicators of the activity of drug metabolizing enzymes. Use of glucaric acid and gamma-glutamyltransferase]. Laboratory tests are increasingly important in the surveillance of drug treatments. People in charge of clinical laboratory science must now become aware of a new development, the ... | [
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PMID:28056 | [Gamma-glutamyltransferase. Human pathology and animal biology]. | Gamma-glutamyltransferase (GGT, EC 2.3.2.2) is in man and animals mainly a renal enzyme. It is also present in non-negligeable quantities in the liver except in certain rodents such as the rat. In the cells, the cytosoluble fraction of the enzyme is very low and most of the enzyme is linked to the microsomal fraction i... | [Gamma-glutamyltransferase. Human pathology and animal biology]. Gamma-glutamyltransferase (GGT, EC 2.3.2.2) is in man and animals mainly a renal enzyme. It is also present in non-negligeable quantities in the liver except in certain rodents such as the rat. In the cells, the cytosoluble fraction of the enzyme is very ... | [
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PMID:28057 | [Neutral leucinamidasic activity of human serum. Semiautomatic method of analysis]. | Half automated method for determining a L-leucinamide splitting enzymatic activity in human sera. In normal and pathological human sera, two distinct L-leucinamide splitting enzymatic activities have been demonstrated. One of them has an optimal activity at pH 9 (alcaline leucine amidase activity) and shows the most pr... | [Neutral leucinamidasic activity of human serum. Semiautomatic method of analysis]. Half automated method for determining a L-leucinamide splitting enzymatic activity in human sera. In normal and pathological human sera, two distinct L-leucinamide splitting enzymatic activities have been demonstrated. One of them has a... | [
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PMID:28058 | Safety of therapy for allergic symptoms during pregnancy. | We undertook a literature review to document whether certain therapeutic measures could be considered safe during pregnancy in the allergic patient. With the possible exception of brompheniramine, the commonly used antihistamine drugs appear to be safe during pregnancy. The bronchodilators ephedrine and theophylline al... | Safety of therapy for allergic symptoms during pregnancy. We undertook a literature review to document whether certain therapeutic measures could be considered safe during pregnancy in the allergic patient. With the possible exception of brompheniramine, the commonly used antihistamine drugs appear to be safe during pr... | [
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PMID:28059 | Bilateral central retinal artery occlusions in polyarteritis nodosa. | The third reported case of bilateral central retinal artery occlusion associated with polyarteritis nodosa is presented. An alternative etiology of the frequently observed association of polyarteritis nodosa with optic atrophy is suggested. A plan of therapy is recommended. | Bilateral central retinal artery occlusions in polyarteritis nodosa. The third reported case of bilateral central retinal artery occlusion associated with polyarteritis nodosa is presented. An alternative etiology of the frequently observed association of polyarteritis nodosa with optic atrophy is suggested. A plan of ... | [
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PMID:28061 | beta-Blockers and the eye: an overview. | Some beta-adrenoceptor blocking drugs are exciting new ocular hypotensive compounds. Unlike pilocarpine, the mainstay of glaucoma treatment for the last 100 years, beta-blocking agents do not contract the pupil nor interfere with vision even in patients with central lens opacities. They also do not cause spasm of the c... | beta-Blockers and the eye: an overview. Some beta-adrenoceptor blocking drugs are exciting new ocular hypotensive compounds. Unlike pilocarpine, the mainstay of glaucoma treatment for the last 100 years, beta-blocking agents do not contract the pupil nor interfere with vision even in patients with central lens opacitie... | [
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PMID:28065 | Athlete exertion injuries. | Over a period of three years 829 cases of greater than or equal to 16-year-old athlete exertion injuries and syndromes were collected. There were 75 women and 754 men in the series. About 90% of the athletes had been training regularly for more than two years, and 75% of them trained 6 times a week or more. Approximate... | Athlete exertion injuries. Over a period of three years 829 cases of greater than or equal to 16-year-old athlete exertion injuries and syndromes were collected. There were 75 women and 754 men in the series. About 90% of the athletes had been training regularly for more than two years, and 75% of them trained 6 times ... | [
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PMID:28066 | A short review of techniques for the localisation of gamma-glutamyl transferase isoenzymes after electrophoresis. | The development of a sensitive method for the localisation of gamma-glutamyl transferase isoenzymes after electrophoresis on various media is described. Recommendations on final conditions are given for optimal concentrations of substrate, acceptor and buffer, and for pH of the reaction mixture. The reaction conditions... | A short review of techniques for the localisation of gamma-glutamyl transferase isoenzymes after electrophoresis. The development of a sensitive method for the localisation of gamma-glutamyl transferase isoenzymes after electrophoresis on various media is described. Recommendations on final conditions are given for opt... | [
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PMID:28067 | Butanol extraction of serum and urinary gamma-glutamyltransferase and its application in clinical diagnosis. | Gamma-glutamyltransferase (gamma-GT) activity was measured in serum and urine before and after extraction with n-butanol. Residual gamma-GT activity after extraction of normal serum with butanol was more than 75%, whereas for normal urine the figure was less than 68%. The loss of activity from urine was not affected by... | Butanol extraction of serum and urinary gamma-glutamyltransferase and its application in clinical diagnosis. Gamma-glutamyltransferase (gamma-GT) activity was measured in serum and urine before and after extraction with n-butanol. Residual gamma-GT activity after extraction of normal serum with butanol was more than 75... | [
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PMID:28068 | Anomalous behaviour of control sera in automated versions of the Kind and King alkaline phosphatase method. | Differences in alkaline phosphatase activity of some commerical control sera were observed when comparing manual with AutoAnalyzer versions of the Kind and King procedure. This phenomenon was found to be associated with sera boosted with exogenous alkaline phosphatase and to be owing mainly to inadequate provision of b... | Anomalous behaviour of control sera in automated versions of the Kind and King alkaline phosphatase method. Differences in alkaline phosphatase activity of some commerical control sera were observed when comparing manual with AutoAnalyzer versions of the Kind and King procedure. This phenomenon was found to be associat... | [
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PMID:28069 | A comparison of two methods of quality control of pH, Pco2, and Po2 measurements. | pH, Pco2, and Po2 measurements have been made over a three-week period on General Diagnostics Blood GAS Control Ampoules and on a tonometered buffer system. The latter seems adequate as a precision and accuracy control of pH, Pco2, and Po2 measurements in a single solution. The former seems adequate as a precision cont... | A comparison of two methods of quality control of pH, Pco2, and Po2 measurements. pH, Pco2, and Po2 measurements have been made over a three-week period on General Diagnostics Blood GAS Control Ampoules and on a tonometered buffer system. The latter seems adequate as a precision and accuracy control of pH, Pco2, and Po... | [
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PMID:28070 | A comparison between metoprolol and pindolol in the treatment of essential hypertension. | The antihypertensive effects on metoprolol and pindolol were compared in 50 patients with essential hypertension belonging to WHO stage 1 or 2. After four weeks of placebo treatment the patients were randomly allocated to treatment with metoprolol or pindolol. During the initial dose-titration period of six weeks the d... | A comparison between metoprolol and pindolol in the treatment of essential hypertension. The antihypertensive effects on metoprolol and pindolol were compared in 50 patients with essential hypertension belonging to WHO stage 1 or 2. After four weeks of placebo treatment the patients were randomly allocated to treatment... | [
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PMID:28071 | Penbutolol, a new non-selective beta-adrenergic blocking compound in the treatment of hypertension. A comparision with propranolol. | The antihypertensive effect of a new non-selective beta-adrenergic blocking compound, penbutolol (40 mg b.i.d.), was compared with propranolol (160 mg b.i.d.) in a series of 20 hypertensive patients using a double-blind cross-over scheme. Both compounds reduced both the supine and the standing blood pressure significan... | Penbutolol, a new non-selective beta-adrenergic blocking compound in the treatment of hypertension. A comparision with propranolol. The antihypertensive effect of a new non-selective beta-adrenergic blocking compound, penbutolol (40 mg b.i.d.), was compared with propranolol (160 mg b.i.d.) in a series of 20 hypertensiv... | [
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PMID:28072 | Response of left ventricular myocardial perfusion and cavity size to beta-blockade by acebutolol. | The effect of beta-blockade by acebutolol on global and regional myocardial perfusion (133Xenon wash-out) was studied in 10 patients with coronary artery disease. Another group of 10 similar patients was used to study the effect of acebutolol on left ventricular cavity size (metal markers--spot film camera). Global per... | Response of left ventricular myocardial perfusion and cavity size to beta-blockade by acebutolol. The effect of beta-blockade by acebutolol on global and regional myocardial perfusion (133Xenon wash-out) was studied in 10 patients with coronary artery disease. Another group of 10 similar patients was used to study the ... | [
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PMID:28073 | Further characterization of bound measles-specific IgG eluted from SSPE brains. | Tissue residues from 3 SSPE brains extracted at neutral pH were thoroughly washed with phosphate-buffered saline and further extracted at acidic pH. The low-pH extracts had significant measles antibody titers, and their measles-specific IgG content ranged from 40 to 60% of total IgG. Agarose-gel electrophoretic analysi... | Further characterization of bound measles-specific IgG eluted from SSPE brains. Tissue residues from 3 SSPE brains extracted at neutral pH were thoroughly washed with phosphate-buffered saline and further extracted at acidic pH. The low-pH extracts had significant measles antibody titers, and their measles-specific IgG... | [
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PMID:28076 | Extracellular accumulation of a new amino acid, O-2-hydroxypropylhomoserine, from 1,2-propanediol by flavobacterium rigense. | During an investigation of microorganisms utilizing petrochemicals, a strain identified as Flavobacterium rigense was found to accumulate a new amino acid in a medium containing 1,2-propanediol as the sole carbon source. Cultural conditions for the accumulation of the product were investigated, and as a result, the yie... | Extracellular accumulation of a new amino acid, O-2-hydroxypropylhomoserine, from 1,2-propanediol by flavobacterium rigense. During an investigation of microorganisms utilizing petrochemicals, a strain identified as Flavobacterium rigense was found to accumulate a new amino acid in a medium containing 1,2-propanediol a... | [
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PMID:28077 | Viral aggregation: quantitation and kinetics of the aggregation of poliovirus and reovirus. | The aggregation of poliovirus and reovirus was followed in buffers at various pH values by means of a single particle analysis (SPA) test. The SPA test used here was modified from the original test reported earlier to prevent disaggregation of virus clumps from invalidating the results. The modified SPA test demonstrat... | Viral aggregation: quantitation and kinetics of the aggregation of poliovirus and reovirus. The aggregation of poliovirus and reovirus was followed in buffers at various pH values by means of a single particle analysis (SPA) test. The SPA test used here was modified from the original test reported earlier to prevent di... | [
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PMID:28078 | Viral aggregation: effects of salts on the aggregation of poliovirus and reovirus at low pH. | As a first step toward the understanding of virus particle interactions in water, we have used the modified single particle analysis test to follow the aggregation of poliovirus and reovirus as induced by low pH in suspensions containing varying amounts of dissolved salts. Salts composed of mono-, di-, and trivalent ca... | Viral aggregation: effects of salts on the aggregation of poliovirus and reovirus at low pH. As a first step toward the understanding of virus particle interactions in water, we have used the modified single particle analysis test to follow the aggregation of poliovirus and reovirus as induced by low pH in suspensions ... | [
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PMID:28079 | Simple method for the isolation of astaxanthin from the basidiomycetous yeast Phaffia rhodozyma. | A method is described for the quantitative and, possibly, large-scale extraction of astaxanthin from the yeast Phaffia rhodozyma. The method utilizes extracellular enzymes produced by the bacterium Bacillus circulans WL-12, which partially digests the yeast cell wall and renders the carotenoid pigments extractable by a... | Simple method for the isolation of astaxanthin from the basidiomycetous yeast Phaffia rhodozyma. A method is described for the quantitative and, possibly, large-scale extraction of astaxanthin from the yeast Phaffia rhodozyma. The method utilizes extracellular enzymes produced by the bacterium Bacillus circulans WL-12,... | [
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PMID:28080 | Sulfide oxidation by spheroplasts of Thiobacillus ferrooxidans. | Thiobacillus ferrooxidans is an acidophilic organism important to metal leaching of low-grade ores. The aforementioned importance is related to the ability of the bacterium to oxidize reduced iron and sulfur, principally found in nature as pyrite (FeS2). The present study dealt with sulfide oxidation at low pH values a... | Sulfide oxidation by spheroplasts of Thiobacillus ferrooxidans. Thiobacillus ferrooxidans is an acidophilic organism important to metal leaching of low-grade ores. The aforementioned importance is related to the ability of the bacterium to oxidize reduced iron and sulfur, principally found in nature as pyrite (FeS2). T... | [
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PMID:28081 | Induction of colonial growth and replica plating of the white rot basidiomycete Phanaerochaete chrysosporium. | A medium containing L-sorbose and sodium deoxycholate was devised which induces colonial growth of Phanaerochaete chrysosporium in the presence of a variety of supplements. The restricted size and heavy conidial production of the colonies permits high plating densities and the use of a replica-plating technique for cop... | Induction of colonial growth and replica plating of the white rot basidiomycete Phanaerochaete chrysosporium. A medium containing L-sorbose and sodium deoxycholate was devised which induces colonial growth of Phanaerochaete chrysosporium in the presence of a variety of supplements. The restricted size and heavy conidia... | [
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PMID:28094 | Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound. | Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal arteries of the rat. In vivo it is a powerful antagonist of bronchospasm induced by ser... | Preliminary data on antiserotonin effects of oxatomide, a novel anti-allergic compound. Oxatomide or R 35443, 1-(3-[4-(diphenylmethyl)-1-piperazinyl]propyl)-1,3-dihydro--2H-benzimidazol-2-one, a compound with potent antihistaminic and anti-anaphylactic activities, shows specific antiserotonin effects on isolated caudal... | [
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PMID:28095 | Discriminable effects of antihistamine drugs. | Rats were trained to discriminate drug vs. no-drug in a shock-escape T-maze task; a right turn was required when rats were drugged and a left turn when undrugged. The three antihistamine drugs pyrilamine, dimenhydrinate (Dramamine) and diphenhydramine (Benadryl) were discriminated after an average of 20 training sessio... | Discriminable effects of antihistamine drugs. Rats were trained to discriminate drug vs. no-drug in a shock-escape T-maze task; a right turn was required when rats were drugged and a left turn when undrugged. The three antihistamine drugs pyrilamine, dimenhydrinate (Dramamine) and diphenhydramine (Benadryl) were discri... | [
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PMID:28096 | Clobazam. A 1.5 benzodiazepine derivative: effects upon human psychomotor performance under different levels of task reinforcement. | Two dose levels of clobazam, a benzodiazepine derivative, were compared to placebo for their effects upon psychomotor performance in an acute dose daytime study with normals. An acute dose of 10 mg clobazam significantly reduced response latencies in the low reinforcement condition of a psychomotor performance task but... | Clobazam. A 1.5 benzodiazepine derivative: effects upon human psychomotor performance under different levels of task reinforcement. Two dose levels of clobazam, a benzodiazepine derivative, were compared to placebo for their effects upon psychomotor performance in an acute dose daytime study with normals. An acute dose... | [
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PMID:28097 | Studies on the inhibition by beta adrenergic receptor agonists of cyclic AMP phosphodiesterase activity of rat heart. | Isoproterenol (10(-5) and 10(-4)M) inhibited a low affinity but not a high affinity form of rat heart cyclic AMP phosphodiesterase. The concentrations of isoproterenol required to produce inhibition of the isolated enzyme were 10,000 to 100,000 fold larger than those required to produce a positive chronotropic response... | Studies on the inhibition by beta adrenergic receptor agonists of cyclic AMP phosphodiesterase activity of rat heart. Isoproterenol (10(-5) and 10(-4)M) inhibited a low affinity but not a high affinity form of rat heart cyclic AMP phosphodiesterase. The concentrations of isoproterenol required to produce inhibition of ... | [
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PMID:28098 | The role of vanadium in green plants. IV. Influence on the formation of delta-aminolevulinic acid in Chlorella. | In a series of experiments, it is demonstrated that the trace element vanadium (4.10(-7) g-at/1 as NH4VO3) has a considerable positive influence on the synthesis of delta-aminolevulinic acid(delta-ALA) in the autotrophically growing green alga Chlorella pyrenoidosa, the effect being visible by an enhanced output of the... | The role of vanadium in green plants. IV. Influence on the formation of delta-aminolevulinic acid in Chlorella. In a series of experiments, it is demonstrated that the trace element vanadium (4.10(-7) g-at/1 as NH4VO3) has a considerable positive influence on the synthesis of delta-aminolevulinic acid(delta-ALA) in the... | [
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PMID:28100 | [Endocrine data in cryptorchism]. | Endocrine evaluation with LH-RH (0.1 mg/m2) and chorionic gonadotrophin (HCG 3 X 1,500 I.U.) in 154 cryptorchid boys aged 1 month to 15 years showed a decrease of LH pituitary secretion and Leydig-cells response to HCG in prepubertal and early pubertal patients. These deficiencies were positively correlated. Partial an... | [Endocrine data in cryptorchism]. Endocrine evaluation with LH-RH (0.1 mg/m2) and chorionic gonadotrophin (HCG 3 X 1,500 I.U.) in 154 cryptorchid boys aged 1 month to 15 years showed a decrease of LH pituitary secretion and Leydig-cells response to HCG in prepubertal and early pubertal patients. These deficiencies were... | [
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PMID:28102 | Standard and long-acting depot neuroleptics in chronic schizophrenics: an 18-month open multicentric study. | The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty French psychiatrists from 15 different wards participated in this experiment. One hundred eighty-one chronic... | Standard and long-acting depot neuroleptics in chronic schizophrenics: an 18-month open multicentric study. The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty ... | [
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PMID:28103 | Vestibular responses in schizophrenia. | In a study of vestibular responses to caloric stimulation that controlled opportunity for fixation and state of alertness, we evaluated previous findings of diminished nystagmus in schizophrenia. We failed to replicate earlier reports in these respects: (1) None of the psychotic patient groups, when compared with norma... | Vestibular responses in schizophrenia. In a study of vestibular responses to caloric stimulation that controlled opportunity for fixation and state of alertness, we evaluated previous findings of diminished nystagmus in schizophrenia. We failed to replicate earlier reports in these respects: (1) None of the psychotic p... | [
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PMID:28104 | [Proteolytic activities in mature human placenta. II. Neutral peptidases and PZ-peptidase (author's transl)]. | Continuing our contributions on proteases of human placenta we enriched some unidentified neutral peptidases by chromatographying freeze dried placenta extracts on CM-Sephadex, followed by preparative isoelectric focusing and chromatography on Ultrogel. By this procedure two Acetyl-aminoacyl-p-nitranilidases, three Ala... | [Proteolytic activities in mature human placenta. II. Neutral peptidases and PZ-peptidase (author's transl)]. Continuing our contributions on proteases of human placenta we enriched some unidentified neutral peptidases by chromatographying freeze dried placenta extracts on CM-Sephadex, followed by preparative isoelectr... | [
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PMID:28105 | Concept of paraneurons. | Paraneurons are those cells which have not been designated as neurons but are recognized as closely related to neurons on the basis of their fine structure (possession of neurosecretion-like and synaptic vesicle-like granules/vacuoles), metabolism (production of neurosecretion- and neurotransmitter-like substances) and... | Concept of paraneurons. Paraneurons are those cells which have not been designated as neurons but are recognized as closely related to neurons on the basis of their fine structure (possession of neurosecretion-like and synaptic vesicle-like granules/vacuoles), metabolism (production of neurosecretion- and neurotransmit... | [
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PMID:28107 | Neuro-epithelial bodies in the lung of the rat and the mouse. | Histochemical and ultrastructural examinations were performed on neuroepithelial bodies (N. E. B.) in the lung of the mouse and rat. The N. E. B. were identified as specialized groups of pale, columnar cells. They were located throughout the intrapulmonary airway. These cells displayed some special cytochemical propert... | Neuro-epithelial bodies in the lung of the rat and the mouse. Histochemical and ultrastructural examinations were performed on neuroepithelial bodies (N. E. B.) in the lung of the mouse and rat. The N. E. B. were identified as specialized groups of pale, columnar cells. They were located throughout the intrapulmonary a... | [
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PMID:28108 | Cimetidine, carbenoxolone sodium, and antacids for the prevention of experimental stress ulcers. | Cimetidine, an H2-receptor, antagonist, and carbenoxolone sodium, a drug used to stimulate gastric mucus synthesis and increase the life span of gastric epithelial cells, were studied to determine their possible prophylactic effect on the formation of stress ulcers, gastric transmucosal potential difference and gastri... | Cimetidine, carbenoxolone sodium, and antacids for the prevention of experimental stress ulcers. Cimetidine, an H2-receptor, antagonist, and carbenoxolone sodium, a drug used to stimulate gastric mucus synthesis and increase the life span of gastric epithelial cells, were studied to determine their possible prophylacti... | [
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PMID:28109 | [The effect of pelleting cereal straw with NaOH-addition on rumen fermentation in cows]. | Experiments with rumen-fistulated dairy cows were performed to study the effect of NaOH-addition to cereal pellets. Compared to straw-concentrate rations in which the straw pellets were free of NaOH, cereal straw pellets containing 2.4 kg NaOH per 100 kg straw caused the rumenal pH to go up from 6.21 to 6.47, the cellu... | [The effect of pelleting cereal straw with NaOH-addition on rumen fermentation in cows]. Experiments with rumen-fistulated dairy cows were performed to study the effect of NaOH-addition to cereal pellets. Compared to straw-concentrate rations in which the straw pellets were free of NaOH, cereal straw pellets containing... | [
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PMID:28110 | [On the toxicology of carbromal. III. Role of active metabolites in humans acutely poisoned with carbromal-containing sedatives (author's transl)]. | Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumoles... | [On the toxicology of carbromal. III. Role of active metabolites in humans acutely poisoned with carbromal-containing sedatives (author's transl)]. Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a t... | [
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PMID:28111 | Hepatotoxic effect of thioacetamide (TAM) on NADP-linked enzymes, aminotransferases and glutamate dehydrogenase. | NADP-linked dehydrogenases, glucose-6-P dehydrogenase (G 6PDH) 6-P gluconate dehydrogenase (6 PGDH), isocitrate dehydrogenase (ICDH), malate dehydrogenase decarboxylating (ME) and aminotransferases GOT and GPT were analyzed in the soluble fraction of blood free homogenates. Glutmate dehydrogenase (GDH) was assayed in t... | Hepatotoxic effect of thioacetamide (TAM) on NADP-linked enzymes, aminotransferases and glutamate dehydrogenase. NADP-linked dehydrogenases, glucose-6-P dehydrogenase (G 6PDH) 6-P gluconate dehydrogenase (6 PGDH), isocitrate dehydrogenase (ICDH), malate dehydrogenase decarboxylating (ME) and aminotransferases GOT and G... | [
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PMID:28112 | Changes in liver tyrosine aminotransferase after acute and chronic administration of morphine in the rat. | Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as mumoles of p-hydroxyphenylpyruvate/100 mg/h. With chronic administration, a tolerance develops to this enzymatic effect. TAT induction is not evident in pregnant rats, given the narcotic, ... | Changes in liver tyrosine aminotransferase after acute and chronic administration of morphine in the rat. Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as mumoles of p-hydroxyphenylpyruvate/100 mg/h. With chronic administration, a tolera... | [
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PMID:28113 | [Morphometric and electron microscopic study of the small intestine following total orthotopical auto- and allotransplantation]. | Total orthotopic autotransplantation of the small intestine was performed in 22 dogs, allotransplantation--in 13 dogs. Changes in the wall of the graft resulted from the effect of both nonspecific (ischaemia, blockage of lymph outflow, denervation) and specific factors connected with the reaction of tissue incompatibil... | [Morphometric and electron microscopic study of the small intestine following total orthotopical auto- and allotransplantation]. Total orthotopic autotransplantation of the small intestine was performed in 22 dogs, allotransplantation--in 13 dogs. Changes in the wall of the graft resulted from the effect of both nonspe... | [
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PMID:28114 | [Morphological characteristics of acute respiratory tract diseases of mixed etiology in children]. | The analysis of 30 etiologically deciphered (by the direct Coons method) autopsy observations of acute respiratory diseases in children under 8 is presented. Monoinfections were established only in 6 cases. Morphological examinations of respiratory organs in 24 cases of mixed acute respiratory diseases (associations of... | [Morphological characteristics of acute respiratory tract diseases of mixed etiology in children]. The analysis of 30 etiologically deciphered (by the direct Coons method) autopsy observations of acute respiratory diseases in children under 8 is presented. Monoinfections were established only in 6 cases. Morphological ... | [
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PMID:28115 | The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis. | Cryptorchidism of the mature rat testis led to degeneration of the seminiferous tubules and changes in enzyme patterns and activities. Spermatogenic stages 1-4, containing pachytene primary spermatocytes in late meiotic prophase, and stage 5, containing recently formed round spermatids, were damaged by 48 h. Within 96 ... | The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis. Cryptorchidism of the mature rat testis led to degeneration of the seminiferous tubules and changes in enzyme patterns and activities. Spermatogenic stages 1-4, containing pachytene primary sperm... | [
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PMID:28118 | Rudimentary locus of Drosophila melanogaster: partial purification of a carbamylphosphate synthase--aspartate transcarbamylase--dihydroorotase complex. | Glutamine-dependent CPSase, ATCase, and DHOase from Drosophila, the first three enzymes in pyrimidine biosynthesis, show coordinate variation in activity throughout development. The three activities were highest in first instar larvae and decreased as development proceeded. The three activities cosediment in sucrose gr... | Rudimentary locus of Drosophila melanogaster: partial purification of a carbamylphosphate synthase--aspartate transcarbamylase--dihydroorotase complex. Glutamine-dependent CPSase, ATCase, and DHOase from Drosophila, the first three enzymes in pyrimidine biosynthesis, show coordinate variation in activity throughout dev... | [
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PMID:28119 | Genetics and physiological expression of beta-hydroxy acid dehydrogenase in Drosophila. | A mutant Hadnl was induced in Drosophila melanogaster and found to be deficient in beta-hydroxy acid dehydrogenase. This mutation was utilized to study the genetics and physiological expression of Had+ . Had+ was mapped to the X chromosome at 54.4 and seems to be the structural gene for the enzyme. Enzyme activity in m... | Genetics and physiological expression of beta-hydroxy acid dehydrogenase in Drosophila. A mutant Hadnl was induced in Drosophila melanogaster and found to be deficient in beta-hydroxy acid dehydrogenase. This mutation was utilized to study the genetics and physiological expression of Had+ . Had+ was mapped to the X chr... | [
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PMID:28133 | Pharmacokinetics of fazadinium in man. | The disposition of fazadinium was studied in 10 patients with normal hepatic and renal function undergoing abdominal surgery. The serum and urinary concentrations were determined fluorimetrically. A single dose of fazadinium 1.5 mg kg-1 was administered i.v. The plasma decay curve for fazadinium was found to be diphasi... | Pharmacokinetics of fazadinium in man. The disposition of fazadinium was studied in 10 patients with normal hepatic and renal function undergoing abdominal surgery. The serum and urinary concentrations were determined fluorimetrically. A single dose of fazadinium 1.5 mg kg-1 was administered i.v. The plasma decay curve... | [
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PMID:28128 | Pharmacokinetics of sulphamethoxazole in man: effects of urinary pH and urine flow on metabolism and renal excretion of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole. | A high performance liquid chromatography method for the determination of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole is described. The renal excretion rate and cumulative renal excretion of sulphamethoxazole is markedly influenced by urinary pH. With constant urinary pH, the renal excretion rate and... | Pharmacokinetics of sulphamethoxazole in man: effects of urinary pH and urine flow on metabolism and renal excretion of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole. A high performance liquid chromatography method for the determination of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazol... | [
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PMID:28134 | The use of chlorazepate for premedication on the night before surgery. | Chlorazepate, a long-acting benzodiazepine, allayed anxiety before operation, being superior to placebo in a double-blind study in which the drug was given the night before surgery. Long-term relief of apprehension before surgery by the administration of chlorazepate, combined with a narcotic analgesic when indicated, ... | The use of chlorazepate for premedication on the night before surgery. Chlorazepate, a long-acting benzodiazepine, allayed anxiety before operation, being superior to placebo in a double-blind study in which the drug was given the night before surgery. Long-term relief of apprehension before surgery by the administrati... | [
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PMID:28135 | Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline. | 1. Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2. These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3. Isoprenaline in contrast with rimiterol produced direct coro... | Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline. 1. Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2. These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for eac... | [
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PMID:28142 | 13C nuclear magnetic resonance study of the cis-trans isomerism in X-Pro-Pro tripeptides. | 13C nuclear magnetic resonance has been used to characterize quantitatively the cis-trans isomerism about both peptide bonds in the tripeptides Ser-Pro-Pro and Arg-Pro-Pro. Detailed pH titration data indicate that the configuration about both peptide bonds is closely linked to titration of the terminal carboxyl group a... | 13C nuclear magnetic resonance study of the cis-trans isomerism in X-Pro-Pro tripeptides. 13C nuclear magnetic resonance has been used to characterize quantitatively the cis-trans isomerism about both peptide bonds in the tripeptides Ser-Pro-Pro and Arg-Pro-Pro. Detailed pH titration data indicate that the configuratio... | [
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PMID:28146 | Enzymatic basis for the Ca2+-induced cross-linking of membrane proteins in intact human erythrocytes. | The accumulation of Ca2+ ions in intact human erythrocytes leads to the production of membrane protein polymers larger than spectrin. The polymer has a heterogeneous size distribution and is rich in gamma-glutamyl-epsilon-lysine cross-links. Isolation of this isodipeptide, in amounts as high as 6 mol/10(5) g of protein... | Enzymatic basis for the Ca2+-induced cross-linking of membrane proteins in intact human erythrocytes. The accumulation of Ca2+ ions in intact human erythrocytes leads to the production of membrane protein polymers larger than spectrin. The polymer has a heterogeneous size distribution and is rich in gamma-glutamyl-epsi... | [
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PMID:28148 | Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism. | The effect of ring substituents on the rates of deacylation of 8 meta- and para-substituted benzoyl papains was evaluated. The rate constants were found to depend upon a single ionizing group of pKa = 4.2--4.3, and to decrease by a factor of approximately 2.2 when measured in 94% D2O/H2O. The rates of deacylation are i... | Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism. The effect of ring substituents on the rates of deacylation of 8 meta- and para-substituted benzoyl papains was evaluated. The rate constants were found to depend upon a single i... | [
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PMID:28149 | The status of tyrosyl residues in a Formosan cobra cardiotoxin. | Spectrophotometric titration of Formosan cobra cardiotoxin showed that two of the three tyrosyl residues were titrated freely with a normal apparent pKa of 9.6 whereas the remaining one ionized at pH above 11.0. Nitration of cardiotoxin in Tris . HCl buffer with tetranitromethane resulted in the selective nitration of ... | The status of tyrosyl residues in a Formosan cobra cardiotoxin. Spectrophotometric titration of Formosan cobra cardiotoxin showed that two of the three tyrosyl residues were titrated freely with a normal apparent pKa of 9.6 whereas the remaining one ionized at pH above 11.0. Nitration of cardiotoxin in Tris . HCl buffe... | [
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PMID:28150 | Spectroscopic studies on the tyrosine residues of canavalin. | Canavalin is a tetramer with 6 tyrosines per subunit. In the work presented here, we have classified these tyrosines by their spectrophotometric and fluorometric pH titration and their ability to be quenched I-. Of the 6 residues, 2 were found to be exposed to the solvent. One (pK = 10.2) contributes 28% of the total f... | Spectroscopic studies on the tyrosine residues of canavalin. Canavalin is a tetramer with 6 tyrosines per subunit. In the work presented here, we have classified these tyrosines by their spectrophotometric and fluorometric pH titration and their ability to be quenched I-. Of the 6 residues, 2 were found to be exposed t... | [
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PMID:28152 | Proton NMR studies on soya bean lipoxygenase-1. | The 270 MHz 1H-NMR spectrum of soya bean lipoxygenase-1 (linoleate: oxygen oxidoreductase, EC 1.13.11.12) was investigated at 298 K and at several pH values. A large fraction of the protein (50%) was found to be effectively random coil. | Proton NMR studies on soya bean lipoxygenase-1. The 270 MHz 1H-NMR spectrum of soya bean lipoxygenase-1 (linoleate: oxygen oxidoreductase, EC 1.13.11.12) was investigated at 298 K and at several pH values. A large fraction of the protein (50%) was found to be effectively random coil. | [
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PMID:28153 | [Role of the electron acceptor properties of lysozyme and its substrate inhibitors in photosensitized electron transport in their complexes by the EPR method]. | The nature of electron-acceptor groups in the system of lysozyme with its substrate-inhibitors has been studied in a wide range of pH values by the method of photosensitized electron transfer. In the lysozyme molecule disulphide bonds and peptide groups are the electron--acceptor groups. The nature of radicals in irrad... | [Role of the electron acceptor properties of lysozyme and its substrate inhibitors in photosensitized electron transport in their complexes by the EPR method]. The nature of electron-acceptor groups in the system of lysozyme with its substrate-inhibitors has been studied in a wide range of pH values by the method of ph... | [
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PMID:28158 | Sympathetic and parasympathetic control of heart rate in unanaesthetized fetal and newborn lambs. | Development of autonomic nervous control of basal heart rate was studied in unanesthetized fetal lambs (93 days to term) and newborn lambs (2--29 days), using atropine and/or propranolol blockade. Fetal lambs showed a progressive increase in parasympathetic restraint of heart rate; vagal influence in the newborn lamb w... | Sympathetic and parasympathetic control of heart rate in unanaesthetized fetal and newborn lambs. Development of autonomic nervous control of basal heart rate was studied in unanesthetized fetal lambs (93 days to term) and newborn lambs (2--29 days), using atropine and/or propranolol blockade. Fetal lambs showed a prog... | [
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PMID:28154 | [Structural changes in cell nuclei in the physiologic pH range]. | Fluorescence of the suspension of cell nuclei from rat liver was investigated under neutral pH range. The pH decrease from 7 to 5 causes the quenching of protein fluorescence of nuclei and leads to an increase of the polarization degree of the fluorescence. Buffering properties of the nuclei in this range were detected... | [Structural changes in cell nuclei in the physiologic pH range]. Fluorescence of the suspension of cell nuclei from rat liver was investigated under neutral pH range. The pH decrease from 7 to 5 causes the quenching of protein fluorescence of nuclei and leads to an increase of the polarization degree of the fluorescenc... | [
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PMID:28159 | Fundamental aspects of antimony thin film electrodes for pH measurement. | This report concerns the investigation of the sensitivity, temperature dependence, accuracy, and the standard electrode potential EO of an antimony thin film pH electrode which was prepared with electron beam evaporation techniques. The air-formed oxide film on antimony thin film electrodes has been proved by both the ... | Fundamental aspects of antimony thin film electrodes for pH measurement. This report concerns the investigation of the sensitivity, temperature dependence, accuracy, and the standard electrode potential EO of an antimony thin film pH electrode which was prepared with electron beam evaporation techniques. The air-formed... | [
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0.0881... |
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