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PMID:28162 | [Use of acetylcholinesterase reactivators and central cholinolytics in the treatment of experimental tetanus poisoning]. | Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinesterase reactivators--dipyroxim and isonitrosine, and also of the central cholinolytics--amizyl and diphacyl. In dose of 25... | [Use of acetylcholinesterase reactivators and central cholinolytics in the treatment of experimental tetanus poisoning]. Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinest... | [
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PMID:28166 | Prediction of wound sepsis following gastric operations. | Gastric aspirates were obtained from 12 healthy volunteers, 49 patients with duodenal ulcer, 14 with gastric ulcer and 35 with gastric carcinoma. The mean total viable bacterial counts in these groups were as follows: volunteers 0, duodenal ulcer 3.8 X 10(1), gastric ulcer 6.95 X 10(4), carcinoma 1.9 X 10(7) organisms/... | Prediction of wound sepsis following gastric operations. Gastric aspirates were obtained from 12 healthy volunteers, 49 patients with duodenal ulcer, 14 with gastric ulcer and 35 with gastric carcinoma. The mean total viable bacterial counts in these groups were as follows: volunteers 0, duodenal ulcer 3.8 X 10(1), gas... | [
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PMID:28174 | Characteristics of Thiobacillus thioparus and its thiocyanate assimilation. | Thiocyanate-assimilatig bacterium, TK 21, was isolated from activated sludge used for the treatment of thiocyanate contained in coke-oven liquor. This organism oxidized thiosulfate and elemental sulfur, causing a decrease of pH of the medium. These facts indicated that it belongs to the genus Thiobacillus. Potassium th... | Characteristics of Thiobacillus thioparus and its thiocyanate assimilation. Thiocyanate-assimilatig bacterium, TK 21, was isolated from activated sludge used for the treatment of thiocyanate contained in coke-oven liquor. This organism oxidized thiosulfate and elemental sulfur, causing a decrease of pH of the medium. T... | [
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PMID:28175 | Oxidation of gallium sulfides by Thiobacillus ferrooxidans. | The bacterial oxidation of naturally occurring gallium-bearing chalcopyrite concentrate and a pure synthetic gallium (III) sulfide has been investigated at pH 1.8 and 35 degree C, using an active culture of Thiobacillus ferrooxidans. This oxidation process may proceed by direct or by indirect bacterial action. The high... | Oxidation of gallium sulfides by Thiobacillus ferrooxidans. The bacterial oxidation of naturally occurring gallium-bearing chalcopyrite concentrate and a pure synthetic gallium (III) sulfide has been investigated at pH 1.8 and 35 degree C, using an active culture of Thiobacillus ferrooxidans. This oxidation process may... | [
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PMID:28178 | Cyclophosphamide-induced oncogenic transformation, chromosomal breakage, and sister chromatid exchange following microsomal activation. | Cyclophosphamide, an extensively used cancer chemotherapeutic agent, requires metabolic activation through a mixed-function oxygenase system. The capacity of this agent to produce oncogenic transformation and chromosomal damage, including increases in sister chromatid exchanges, was investigated in cell culture with or... | Cyclophosphamide-induced oncogenic transformation, chromosomal breakage, and sister chromatid exchange following microsomal activation. Cyclophosphamide, an extensively used cancer chemotherapeutic agent, requires metabolic activation through a mixed-function oxygenase system. The capacity of this agent to produce onco... | [
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PMID:28181 | Complexes of trivalent oxygenated phosphorus compounds with cytochrome P-450 and cytochrome P-420: the origin of double Soret spectra. | Trivalent oxygenated phosphorus ligands include alkyl and aryl phosphites, (RO)3P, phosphonites, (RO)2PR, and phosphinites, ROPR2. All such compounds tested, with the exception of triphenyl phosphite, interact with ferrous cytochrome P-450 and its denatured form, cytochrome P-420, to produce complexes having two peaks ... | Complexes of trivalent oxygenated phosphorus compounds with cytochrome P-450 and cytochrome P-420: the origin of double Soret spectra. Trivalent oxygenated phosphorus ligands include alkyl and aryl phosphites, (RO)3P, phosphonites, (RO)2PR, and phosphinites, ROPR2. All such compounds tested, with the exception of triph... | [
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PMID:28182 | The anaerobic dechlorination of trichlorofluoromethane by rat liver preparations in vitro. | Incubation of trichlorofluoromethane with a liver microsomal fraction and an NADPH generating system under anaerobic conditions produced a metabolite dichlorofluoromethane, characterised by gas chromatography and mass spectrometry. The metabolic reaction was carried out by liver microsomes from the mouse, rabbit, hamst... | The anaerobic dechlorination of trichlorofluoromethane by rat liver preparations in vitro. Incubation of trichlorofluoromethane with a liver microsomal fraction and an NADPH generating system under anaerobic conditions produced a metabolite dichlorofluoromethane, characterised by gas chromatography and mass spectrometr... | [
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PMID:28184 | A comparison of the effects of 5- and 6-hydroxydopamine on the isolated canine saphenous vein. | We studied and compared the effects of 5- and 6-hydroxydopamine (5- or 6-OHDA) on venous tone and on adrenergic and nonadrenergic responses of the isolated canine saphenous vein. In the tissue bath, both 5- and 6-OHDA caused increases in tone and abolished adrenergic responses to transmural nerve stimulation. Effects o... | A comparison of the effects of 5- and 6-hydroxydopamine on the isolated canine saphenous vein. We studied and compared the effects of 5- and 6-hydroxydopamine (5- or 6-OHDA) on venous tone and on adrenergic and nonadrenergic responses of the isolated canine saphenous vein. In the tissue bath, both 5- and 6-OHDA caused ... | [
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PMID:28185 | Separation and analysis of arylsulfatase isoenzymes in body fluids of man. | Soluble arylsulfatase (EC 3.1.6.1) is present in the body fluids of man in the form of two isoenzymes, arylsulfatase A and B, which reportedly are useful biochemical markers for certain types of malignancy. However, rapid assay of the individual isoenzymes is extremely difficult; procedures based on differential inhibi... | Separation and analysis of arylsulfatase isoenzymes in body fluids of man. Soluble arylsulfatase (EC 3.1.6.1) is present in the body fluids of man in the form of two isoenzymes, arylsulfatase A and B, which reportedly are useful biochemical markers for certain types of malignancy. However, rapid assay of the individual... | [
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PMID:28186 | Acid beta-glucosidase and the diagnosis of Gaucher's disease in liver and spleen. | Variable amounts of residual 4-methylumbelliferyl-beta-glucosidase activity gave rise to difficulties in the diagnosis of Gaucher's disease using spleen and particularly liver. Soluble and particulate components of beta-glucosidase, which interfere with the diagnosis, may be eliminated by preincubation of homogenates a... | Acid beta-glucosidase and the diagnosis of Gaucher's disease in liver and spleen. Variable amounts of residual 4-methylumbelliferyl-beta-glucosidase activity gave rise to difficulties in the diagnosis of Gaucher's disease using spleen and particularly liver. Soluble and particulate components of beta-glucosidase, which... | [
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PMID:28187 | Methylmalonic/beta-hydroxy-n-valeric aciduria due to methylmalonyl-CoA mutase deficiency. | A patient with methylmalonic and beta-hydroxy-n-valeric aciduria, apparently due to deficiency of methylmalonyl-CoA mutase, is described. The excretion of beta-hydroxy-n-valerate did not parallel that of beta-hydroxypropionate and methylmalonate but was observed, together with beta-keto-n-valerate, only during ketosis.... | Methylmalonic/beta-hydroxy-n-valeric aciduria due to methylmalonyl-CoA mutase deficiency. A patient with methylmalonic and beta-hydroxy-n-valeric aciduria, apparently due to deficiency of methylmalonyl-CoA mutase, is described. The excretion of beta-hydroxy-n-valerate did not parallel that of beta-hydroxypropionate and... | [
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PMID:28188 | Glycogenosis type II: the infantile- and late-onset acid maltase deficiency observed in one family. | The concurrence of the infantile and adult form of acid maltase deficiency in one family is presented. The muscle of both cases possesses residual activity. The glycogen amount in the infantile form is increased tremendously, while in the late-onset the amount of glycogen is normal. | Glycogenosis type II: the infantile- and late-onset acid maltase deficiency observed in one family. The concurrence of the infantile and adult form of acid maltase deficiency in one family is presented. The muscle of both cases possesses residual activity. The glycogen amount in the infantile form is increased tremendo... | [
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PMID:28189 | Considerations on physiopathological approaches to the treatment of hypertension. | 1. Two main physiopathological approaches to the treatment of hypertension are discussed, the first based on renin profiling and the second on haemodynamic measurements. 2. Reduction in plasma renin activity does not appear to be a clinically important mechanism in the hypotensive effect of beta-adrenergic blockers and... | Considerations on physiopathological approaches to the treatment of hypertension. 1. Two main physiopathological approaches to the treatment of hypertension are discussed, the first based on renin profiling and the second on haemodynamic measurements. 2. Reduction in plasma renin activity does not appear to be a clinic... | [
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PMID:28190 | alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects. | 1. During acute injection of alpha-methyldopa there is a reduction in the blood pressure within a period of a few hours and a modest reduction in the cardiac output, sometimes due to a modest decrease in heart rate. Frequently the total peripheral resistance is decreased. In contrast, acute injection of beta-blockers i... | alpha-Methyldopa and beta-blockers in hypertension--a comparison of their haemodynamic effects. 1. During acute injection of alpha-methyldopa there is a reduction in the blood pressure within a period of a few hours and a modest reduction in the cardiac output, sometimes due to a modest decrease in heart rate. Frequent... | [
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PMID:28191 | Immunotherapy of human acute leukaemia. | Conclusions are difficult to draw. In the six studies of immunotherapy of AML discussed, all the three employing BCG and cells showed a prolongation of survival and the major contributing factor to this prolongation of survival was extension of life after relapse. In the three studies using BCG alone only one shows a b... | Immunotherapy of human acute leukaemia. Conclusions are difficult to draw. In the six studies of immunotherapy of AML discussed, all the three employing BCG and cells showed a prolongation of survival and the major contributing factor to this prolongation of survival was extension of life after relapse. In the three st... | [
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PMID:28193 | Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. | A Phase I evaluation of a new adrenoceptor blocker, pamatolol, was performed in 10 healthy male volunteers. Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observed with the 10-mg oral dose and appeared maximal with the 400-600 mg dose. The rate of decline of effect aver... | Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. A Phase I evaluation of a new adrenoceptor blocker, pamatolol, was performed in 10 healthy male volunteers. Minor reductions in standing and exercise and isoproterenol-induced increases in heart rate were observe... | [
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PMID:28194 | Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results. | In order to assess the subjective effects of nefopam, a new non-opiate analgesic, a study was designed using highly educated, young, middle-to-upper class subjects in a naturalistic setting. Results suggest that the design is capable of differentiating variations in subjective drug effects. On a number of measures, 10 ... | Assessing the subjective effects of stimulants in casual users. A methodology and preliminary results. In order to assess the subjective effects of nefopam, a new non-opiate analgesic, a study was designed using highly educated, young, middle-to-upper class subjects in a naturalistic setting. Results suggest that the d... | [
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PMID:28195 | Analytical subcellular fractionation studies on enterocytes from the jejunum and ileum of the rat and some properties of brush-border alkaline phosphatase. | 1. Enterocytes, isolated from the proximal jejinum and distal ileum of the rat, were homogenized and their organelles separated by isopycnic centrifugation on continuous sucrose density gradients. The distributions of marker enzymes for the principal organelles, RNA and protein were determined in the sucrose gradients ... | Analytical subcellular fractionation studies on enterocytes from the jejunum and ileum of the rat and some properties of brush-border alkaline phosphatase. 1. Enterocytes, isolated from the proximal jejinum and distal ileum of the rat, were homogenized and their organelles separated by isopycnic centrifugation on conti... | [
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PMID:28196 | Urinary dopamine in man and rat: effects of inorganic salts on dopamine excretion. | 1. Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man were greater than could be explained by simple renal clearance. It was concluded that... | Urinary dopamine in man and rat: effects of inorganic salts on dopamine excretion. 1. Plasma and urine free dopamine (3,4-dihydroxyphenethylamine) were measured in six normal male volunteer subjects and the urinary clearance of dopamine was calculated for each subject. 2. The excretion rates for free dopamine in man we... | [
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PMID:28197 | Effect of varying PCO2 on intracellular pH and lactate consumption in the isolated perfused rat liver. | 1. The effects of varying PCO2 on lactate uptake and intracellular pH (pHi) were studied in the isolated rat liver perfused with differing concentration of lactate. 2. In general, pHi and lactate uptake are inversely related to PCO2, and pHi and lactate uptake are directly related to each other, but the quantitative as... | Effect of varying PCO2 on intracellular pH and lactate consumption in the isolated perfused rat liver. 1. The effects of varying PCO2 on lactate uptake and intracellular pH (pHi) were studied in the isolated rat liver perfused with differing concentration of lactate. 2. In general, pHi and lactate uptake are inversely ... | [
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PMID:28198 | Mechanism of the effect of varying PCO2 on gluconeogenesis from lactate in the perfused rat liver. | 1. The effects of varying PCO2 on glucose output and the intracellular concentrations of lactate, pyruvate, phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate were studied in the isolated rat liver perfused with differing concentrations of lactate. 2. When the perfusate lactate concentration is above 1.5 mm... | Mechanism of the effect of varying PCO2 on gluconeogenesis from lactate in the perfused rat liver. 1. The effects of varying PCO2 on glucose output and the intracellular concentrations of lactate, pyruvate, phosphoenolpyruvate, 2-phosphoglycerate and 3-phosphoglycerate were studied in the isolated rat liver perfused wi... | [
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PMID:28219 | [Crohn's disease: course and prognosis in 169 patients (author's transl)]. | The most common initial symptoms in 169 patients with Crohn's disease, followed from 1956 to 1973, were diffuse abdominal pain, diarrhoea without any blood admixture, loss of weight, and fever. At the onset of the disease 84% of patients were aged 10-39 years. The most important complications (in descending order of fr... | [Crohn's disease: course and prognosis in 169 patients (author's transl)]. The most common initial symptoms in 169 patients with Crohn's disease, followed from 1956 to 1973, were diffuse abdominal pain, diarrhoea without any blood admixture, loss of weight, and fever. At the onset of the disease 84% of patients were ag... | [
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PMID:28220 | Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs). | The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric O2. Quantitative recoveries of all PBBs were obtained after incubations with control or 3-methylcholanthrene (MC) induced microsomes. Of the twelve major components, losses of on... | Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs). The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric O2. Quantitative recoveries of all PBBs were obtained after incubations with control or 3-met... | [
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PMID:28225 | Purification and properties of 5'-nucleotidase from lymphocyte plasma membranes. | 5'-Nucleotidase is purified from lymphocyte plasma membranes by two affinity chromatographies. The first one, on Lens culinaris lectin-Sepharose 4B yields a fraction of twelve lectin-binding glycoproteins (lectin-receptor fraction). The second one on 5'-AMP-Sepharose 4B leads to pure enzyme. This enzyme is a glycoprote... | Purification and properties of 5'-nucleotidase from lymphocyte plasma membranes. 5'-Nucleotidase is purified from lymphocyte plasma membranes by two affinity chromatographies. The first one, on Lens culinaris lectin-Sepharose 4B yields a fraction of twelve lectin-binding glycoproteins (lectin-receptor fraction). The se... | [
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PMID:28227 | Purification of aspartate transcarbamylase from Drosophila melanogaster. | A purification procedure is described by which aspartate transcarbamylase was obtained from cultured cells of Drosophila melanogaster as part of a high-molecular-weight enzyme complex. The complex is shown to contain several polypeptides. An antiserum directed against the complex enzyme inhibited in vitro the activity ... | Purification of aspartate transcarbamylase from Drosophila melanogaster. A purification procedure is described by which aspartate transcarbamylase was obtained from cultured cells of Drosophila melanogaster as part of a high-molecular-weight enzyme complex. The complex is shown to contain several polypeptides. An antis... | [
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PMID:28228 | Identification of the functional ionic groups of papain by pH/rate profile analysis. | The pH dependence of papain catalysis was analyzed by a scheme which evaluates the kinetic contribution of both protonated and unprotonated species of functional groups involved in catalysis. Kinetic measurements were made at constant pH, without buffers, by automatic titration. The rate-determining step for papain-cat... | Identification of the functional ionic groups of papain by pH/rate profile analysis. The pH dependence of papain catalysis was analyzed by a scheme which evaluates the kinetic contribution of both protonated and unprotonated species of functional groups involved in catalysis. Kinetic measurements were made at constant ... | [
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PMID:28230 | Hyperphenylalaninaemia due to dihydropteridine reductase deficiency. | Two siblings with increased levels of serum phenylalanine were detected by newborn screening. The older sibling deteriorated neurologically and mentally, despite early dietary control, and died at the age of 6 1/2 years. In the younger sibling phenylalanine hydroxylase activity in liver tissue was normal. Further inves... | Hyperphenylalaninaemia due to dihydropteridine reductase deficiency. Two siblings with increased levels of serum phenylalanine were detected by newborn screening. The older sibling deteriorated neurologically and mentally, despite early dietary control, and died at the age of 6 1/2 years. In the younger sibling phenyla... | [
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PMID:28231 | Effects of stored and fresh blood transfusions on postoperative pulmonary function. A clinical study on patients following extracorporeal circulation in association with aortic valve surgery. | The effects on postoperative pulmonary function of fresh versus stored blood when priming the heart-lung machine were studied in 49 patients subjected to aortic valvular replacement. The onset of extracorporeal circulation was considered to mimic the conditions of massive blood transfusion. The patients receiving hepar... | Effects of stored and fresh blood transfusions on postoperative pulmonary function. A clinical study on patients following extracorporeal circulation in association with aortic valve surgery. The effects on postoperative pulmonary function of fresh versus stored blood when priming the heart-lung machine were studied in... | [
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PMID:28232 | Hemodynamic and metabolic changes induced by temporary clamping of the thoracic aorta. | Numerous authors reported a significant deterioration of heart function induced by aortic cross-clamping. Nevertheless, the aorta has been clamped during various surgical procedures without any complication. We studied the hemodynamic and metabolic variations induced by 20 min thoracic aorta cross-clamping in 6 open-ch... | Hemodynamic and metabolic changes induced by temporary clamping of the thoracic aorta. Numerous authors reported a significant deterioration of heart function induced by aortic cross-clamping. Nevertheless, the aorta has been clamped during various surgical procedures without any complication. We studied the hemodynami... | [
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PMID:28233 | Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. | Apomorphine and the putative dopamine agonist, 2-(N, N-dipropyl)-amino-5, 6-dihydroxytetralin induced dose-dependent climbing behaviour in the mouse which was measured in wire mesh lined cages as the percentage of time spent climbing in the 30 min period following the first climb and as the maximum time spent in a sing... | Climbing behaviour induced by apomorphine in mice: a potential model for the detection of neuroleptic activity. Apomorphine and the putative dopamine agonist, 2-(N, N-dipropyl)-amino-5, 6-dihydroxytetralin induced dose-dependent climbing behaviour in the mouse which was measured in wire mesh lined cages as the percenta... | [
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PMID:28234 | The influence of heart rate on ouabain cardiotoxicity in cats with spinal cord transection. | The dose, serum level and ventricular content of ouabain needed to produce cardiotoxicity were examined in control cats, cats with transected spinal cords and cats with transected spinal cords whose heart rates were restored to control values by artificial pacing. The lethal dose of ouabain was higher in cats with tran... | The influence of heart rate on ouabain cardiotoxicity in cats with spinal cord transection. The dose, serum level and ventricular content of ouabain needed to produce cardiotoxicity were examined in control cats, cats with transected spinal cords and cats with transected spinal cords whose heart rates were restored to ... | [
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PMID:28236 | Halothane-induced sleeping time in the mouse: its modification by benzodiazepines. | The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbiturates to induce hypnosis; due cognizance must be taken of a diurnal variation in the ... | Halothane-induced sleeping time in the mouse: its modification by benzodiazepines. The conditions under which prolongation of halothane-induced sleeping time in the mouse may be used as a test for centrally acting drugs are described. The test can be recommended for its practical advantages over methods using barbitura... | [
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PMID:28237 | Relaxation of depolarized guinea pig taenia caecum induced by some antispasmodics. | Taenia isolated from the guinea pig caecum were used for the experiments. No inhibitory response of the depolarized taenia to isoprenaline was observed during the significant increase of cyclic AMP level. These observations suggest that the total tissue level of cyclic AMP is not an important determinant of relaxation ... | Relaxation of depolarized guinea pig taenia caecum induced by some antispasmodics. Taenia isolated from the guinea pig caecum were used for the experiments. No inhibitory response of the depolarized taenia to isoprenaline was observed during the significant increase of cyclic AMP level. These observations suggest that ... | [
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PMID:28250 | Steric aspects of dopaminergic drugs. | There are a variety of molecule species of dopamine avaialable at physiological pH. The predominant form available at physiological pH is the phenolic ammonium salt. However, at the present time the molecular form that is optimum for producing dopaminergic activity is unknown. In attempting to delineate the conformatio... | Steric aspects of dopaminergic drugs. There are a variety of molecule species of dopamine avaialable at physiological pH. The predominant form available at physiological pH is the phenolic ammonium salt. However, at the present time the molecular form that is optimum for producing dopaminergic activity is unknown. In a... | [
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PMID:28254 | [Several new inhibitors of gastric secretion]. | In experiments on dogs, milid (proglymid) entailed a weak inhibition of the 2nd phase of the gastric secretion leaving intact the 1st phase. The action of LS-519 was obvious in the 1st phase, having entailed a significant inhibition. The glycomacropeptid exerted a strong inhibiting effect both on the 1st and the 2nd ph... | [Several new inhibitors of gastric secretion]. In experiments on dogs, milid (proglymid) entailed a weak inhibition of the 2nd phase of the gastric secretion leaving intact the 1st phase. The action of LS-519 was obvious in the 1st phase, having entailed a significant inhibition. The glycomacropeptid exerted a strong i... | [
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PMID:28255 | Ergonomics. Reducing mental and physical fatigue in the dental operatory. | The work output and the mental and physical fatigue generated by a dental procedure is affected by the length and type of operation, physical facilities, the amount of cooperation given by the patient, operating techniques, and the effective teamwork and rapport of the operatory dental team. Fatigue is also generated b... | Ergonomics. Reducing mental and physical fatigue in the dental operatory. The work output and the mental and physical fatigue generated by a dental procedure is affected by the length and type of operation, physical facilities, the amount of cooperation given by the patient, operating techniques, and the effective team... | [
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PMID:28260 | Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines. | Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, i... | Adenylate cyclase of human gastric mucosa. Stimulation of enzyme activity by histamine and catecholamines. Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and pro... | [
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PMID:28261 | Fecal chymotrypsin: study on some characteristics of the enzyme. | A Lineweaver-Burk plot demonstrated that the apparent Michaelis constants are identical for chymotrypsin (CT) in duodenal juice and in feces of the same patient. CT in fecal homogenates exhibits exhibits a remarkable stability and is bound to particles to a considerable but variable extent. The pH optimum of CT in huma... | Fecal chymotrypsin: study on some characteristics of the enzyme. A Lineweaver-Burk plot demonstrated that the apparent Michaelis constants are identical for chymotrypsin (CT) in duodenal juice and in feces of the same patient. CT in fecal homogenates exhibits exhibits a remarkable stability and is bound to particles to... | [
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PMID:28263 | Polyarteritis nodosa causing severe intestinal bleeding. | Rupture of an aneurysm of the mesentergic artery caused severe intestinal hemorrhage in a 50-year-old woman with polyarteritis nodosa. Abdominal angiography not only established diagnosis of polyarteritis nodosa by demonstrating multiple visceral aneurysms but also localized the site of bleeding. | Polyarteritis nodosa causing severe intestinal bleeding. Rupture of an aneurysm of the mesentergic artery caused severe intestinal hemorrhage in a 50-year-old woman with polyarteritis nodosa. Abdominal angiography not only established diagnosis of polyarteritis nodosa by demonstrating multiple visceral aneurysms but al... | [
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PMID:28264 | Non-beta islet cell tumor calcification assoicated with Zollinger-Ellison syndrome and multiple endocrine adenomatosis. | The radiographic triad of a calcified pancreatic mass, duodenal ulcers, and nephrocalcinosis should suggest the Zollinger-Ellison syndrome, as part of the multiple endocrine adenomatosis complex. The clinical and radiographic features of the entity are described in this case report. | Non-beta islet cell tumor calcification assoicated with Zollinger-Ellison syndrome and multiple endocrine adenomatosis. The radiographic triad of a calcified pancreatic mass, duodenal ulcers, and nephrocalcinosis should suggest the Zollinger-Ellison syndrome, as part of the multiple endocrine adenomatosis complex. The ... | [
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PMID:28269 | Recognition of alcoholic liver disease in a district general hospital. | Two-hundred-and-two patients with alcoholic liver disease whose investigations included a liver biopsy were seen in a district general hospital over a seven year period. Thirty-five percent presented with general gastrointestinal symptoms rather than with overt liver disease or previously recognised excess consumption ... | Recognition of alcoholic liver disease in a district general hospital. Two-hundred-and-two patients with alcoholic liver disease whose investigations included a liver biopsy were seen in a district general hospital over a seven year period. Thirty-five percent presented with general gastrointestinal symptoms rather tha... | [
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PMID:28270 | Postprandial duodenal function in man. | Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly c... | Postprandial duodenal function in man. Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absor... | [
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PMID:28271 | Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption. | The surface pH of human proximal jejunum was measured in biopsy samples and found to be more acid than the phosphate buffer in which they were incubated. The in vitro jejunal surface pH was 5.93 +/- 0.05 in control subjects and 6.19 +/- 0.09 in treated coeliac patients. A group of untreated coeliac patients with a surf... | Acid microclimate in coeliac and Crohn's disease: a model for folate malabsorption. The surface pH of human proximal jejunum was measured in biopsy samples and found to be more acid than the phosphate buffer in which they were incubated. The in vitro jejunal surface pH was 5.93 +/- 0.05 in control subjects and 6.19 +/-... | [
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PMID:28272 | Effects of phospholipase A and triton x-100 on guanylate cyclase activity in mammary gland homogenates from mice. | The effects of a variety of agents on guanylate cyclase activity were tested in broken cell preparations of mammary glands from midpregnant mice. Of the agents tested, only phospholipase A, triton X-100, and an impure egg lysolecithin preparation enhanced the activity of guanylate cyclase in mammary gland homogenates; ... | Effects of phospholipase A and triton x-100 on guanylate cyclase activity in mammary gland homogenates from mice. The effects of a variety of agents on guanylate cyclase activity were tested in broken cell preparations of mammary glands from midpregnant mice. Of the agents tested, only phospholipase A, triton X-100, an... | [
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PMID:28274 | Rapid formation of N-nitrosamines from nitrogen oxides under neutral and alkaline conditions. | The formation of carcinogenic N-nitrosamines in neutral and alkaline aqueous solutions (pH 6-14) at 25 degrees C is reported using dissolved N2O3 and N2O4 gases. These reactions are very much faster than those with acidified nitrite: typically, 2 X 10(-3) M amine gives ca. 10-50% N-nitrosamine in a few seconds with 5-2... | Rapid formation of N-nitrosamines from nitrogen oxides under neutral and alkaline conditions. The formation of carcinogenic N-nitrosamines in neutral and alkaline aqueous solutions (pH 6-14) at 25 degrees C is reported using dissolved N2O3 and N2O4 gases. These reactions are very much faster than those with acidified n... | [
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PMID:28275 | Mechanism of N-nitrosodimethylamine formation from trimethylamine and trimethylaminoxide. | The kinetics of nitrosation of trimethylamine (TMA) and trimethylaminoxide (TMAO) to give N-nitrosodimethylamine (NDMA) have been studied. The nitrosation rates of TMA and TMAO, when determined at 100 degrees C in sealed tubes, showed maximum values at about pH 3, while at temperatures lower than 75 degrees C the pH de... | Mechanism of N-nitrosodimethylamine formation from trimethylamine and trimethylaminoxide. The kinetics of nitrosation of trimethylamine (TMA) and trimethylaminoxide (TMAO) to give N-nitrosodimethylamine (NDMA) have been studied. The nitrosation rates of TMA and TMAO, when determined at 100 degrees C in sealed tubes, sh... | [
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PMID:28276 | Some effects of phenol- and thiol-nitrosation reactions on N-nitrosamine formation. | C-Nitrosophenols, produced by the nitrosation of phenols, catalyse N-nitrosamine formation. The rate of N-nitrosation of pyrrolidine, catalysed by p-nitroso-o-cresol, is fastest at about pH 5. The catalytic species is thought to be the quinone monoxime tautomer of the nitrosophenol. A possible mechanism for the catalys... | Some effects of phenol- and thiol-nitrosation reactions on N-nitrosamine formation. C-Nitrosophenols, produced by the nitrosation of phenols, catalyse N-nitrosamine formation. The rate of N-nitrosation of pyrrolidine, catalysed by p-nitroso-o-cresol, is fastest at about pH 5. The catalytic species is thought to be the ... | [
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PMID:28277 | Alpha-tocopherol: uses in preventing nitrosamine formation. | alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. The use of alpha-tocopherol was shown to inhibit aminopyrene-n... | Alpha-tocopherol: uses in preventing nitrosamine formation. alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. Th... | [
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PMID:28279 | Acceleration of nitrosamine formation at pH 3.5 by microorganisms. | Rate enhancements of from 12 to 49-fold occurred when dihexylamine was nitrosated at pH 3.5 in the presence of bacteria and yeast cells at a concentration of 12 mg/ml. Rates were similar in the presence of either boiled or unheated cells. The magnitude of the rate enhancement for nitrosation of other amines depended on... | Acceleration of nitrosamine formation at pH 3.5 by microorganisms. Rate enhancements of from 12 to 49-fold occurred when dihexylamine was nitrosated at pH 3.5 in the presence of bacteria and yeast cells at a concentration of 12 mg/ml. Rates were similar in the presence of either boiled or unheated cells. The magnitude ... | [
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PMID:28282 | Preliminary observations on amines and nitrosamines in non-normal human gastric contents. | Gastric contents from fasting humans were pooled and analysed for amines. Volatile amines present were dimethylamine, trimethylamine and histamine; non-volatile amines found were cadaverine, putrescine, ethanolamine and tryptamine. Gastric contents from 35 patients, some before and/or after gastric stimulation with his... | Preliminary observations on amines and nitrosamines in non-normal human gastric contents. Gastric contents from fasting humans were pooled and analysed for amines. Volatile amines present were dimethylamine, trimethylamine and histamine; non-volatile amines found were cadaverine, putrescine, ethanolamine and tryptamine... | [
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PMID:28285 | Homologous and cross-reactive precipitins in anti-pneumococcal sera raised in mules. | Serial bleedings were obtained from two mules during prolonged immunization, one with type XXV the other with type VIII pneumococcal vaccine. IgGa, IgGb, IgGc, IgB, IgG(T) and IgM present among purified Pn anti-XXV and Pn anti-VIII immunoglobulin isolated from various bleedings were identified by use of rabbit anti-equ... | Homologous and cross-reactive precipitins in anti-pneumococcal sera raised in mules. Serial bleedings were obtained from two mules during prolonged immunization, one with type XXV the other with type VIII pneumococcal vaccine. IgGa, IgGb, IgGc, IgB, IgG(T) and IgM present among purified Pn anti-XXV and Pn anti-VIII imm... | [
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PMID:28293 | Ionic binding of aminoglycosides to human serum albumin in the absence of divalent cations. IV. Effect of structure, ph and concentration. | The binding of sisomicin and streptomycin to human serum albumin was studied in the absence of divalent cations by means of the dialysis method. Hydrophobic bonds between albumin and sisomicin or streptomycin can be excluded by nuclear magnetic resonance measurements. The presence of hydrogen bonds is made unlikely acc... | Ionic binding of aminoglycosides to human serum albumin in the absence of divalent cations. IV. Effect of structure, ph and concentration. The binding of sisomicin and streptomycin to human serum albumin was studied in the absence of divalent cations by means of the dialysis method. Hydrophobic bonds between albumin an... | [
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PMID:28288 | Factors affecting in vitro lipid peroxidation of rat brain homogenate. | Peroxidation of the unsaturated lipid of tissue homogenates is an established method to assess the antioxidant or vitamin E status of animals. In the present study the spontaneous lipid peroxidation in air of rat brain homogenates is reported. The effects of various factors like pH, time, concentration of tissues, temp... | Factors affecting in vitro lipid peroxidation of rat brain homogenate. Peroxidation of the unsaturated lipid of tissue homogenates is an established method to assess the antioxidant or vitamin E status of animals. In the present study the spontaneous lipid peroxidation in air of rat brain homogenates is reported. The e... | [
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PMID:28289 | Enhancement of insulin hypoglycaemia by beta adrenoceptor antagonists. | Interaction of insulin with beta-adrenoceptor antagonists was studied in conscious rabbits. Propranolol and metoprolol did not modify the peak of insulin hypoglycaemia but delayed its recovery. Practolol, sotalol and 1-INPEA enhanced the peak effect and delayed the recovery of insulin-induced hypoglycaemia. H 35/25 and... | Enhancement of insulin hypoglycaemia by beta adrenoceptor antagonists. Interaction of insulin with beta-adrenoceptor antagonists was studied in conscious rabbits. Propranolol and metoprolol did not modify the peak of insulin hypoglycaemia but delayed its recovery. Practolol, sotalol and 1-INPEA enhanced the peak effect... | [
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PMID:28290 | Acetylcholine: a possible neurotransmitter in Setaria cervi. | The total and free acetylcholine (Ach) and cholinesterase (CHE) content of adult Setaria cervi were estimated. The Ach was estimated by bioassay on rectus abdominis muscle of frog and the CHE by measuring the drop in pH following incubation of worm homogenate with Ach chloride. The free and total Ach contents (4.0 +/- ... | Acetylcholine: a possible neurotransmitter in Setaria cervi. The total and free acetylcholine (Ach) and cholinesterase (CHE) content of adult Setaria cervi were estimated. The Ach was estimated by bioassay on rectus abdominis muscle of frog and the CHE by measuring the drop in pH following incubation of worm homogenate... | [
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PMID:28295 | Inhibition of allergic reactions by a new antiallergic drug, LC-6 (trans-2,3b,4,5,7,8b,9,10-octahydronaphthol[1,2-c:5,6-c'] dipyrazole). I. Inhibition of the rat reaginic passive cutaneous anaphylaxis. | A new synthetic compound, LC-6, has been shown to inhibit the passive cutaneous anaphylaxis reactions induced in rats by mouse reaginic antibody. In this system, the ED50 was 35 mg/kg body weight of LC-6 administered per os. LC-6 prevented neither histamine skin reactions nor the reactions to histamine and other chemic... | Inhibition of allergic reactions by a new antiallergic drug, LC-6 (trans-2,3b,4,5,7,8b,9,10-octahydronaphthol[1,2-c:5,6-c'] dipyrazole). I. Inhibition of the rat reaginic passive cutaneous anaphylaxis. A new synthetic compound, LC-6, has been shown to inhibit the passive cutaneous anaphylaxis reactions induced in rats ... | [
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PMID:28291 | Effect of light and exhaustive ergometric exercise on blood sugar, total cholesterol and pH in untrained young human subjects. | Light and exhaustive ergometric exercise in untrained male and female medical students in the age group 18-21 years resulted in significant lowering of the blood sugar, cholesterol and pH. Females exhibited hypoglycemia of slightly greater magnitude as compared to male subjects and during both the exercises, however, s... | Effect of light and exhaustive ergometric exercise on blood sugar, total cholesterol and pH in untrained young human subjects. Light and exhaustive ergometric exercise in untrained male and female medical students in the age group 18-21 years resulted in significant lowering of the blood sugar, cholesterol and pH. Fema... | [
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PMID:28296 | Immunological nature of the inhibition of BLV-induced early polykaryocytosis by bovine sera. | A quantitative in vitro assay (EPI) was developed for the serological detection of bovine leukemia virus (BLV) infection in cattle. Positive sera inhibit early polykaryocytosis (EP) induced by BLV. We report herein experiments which demonstrate that BLV-induced antibodies are responsible for this inhibition. Serum frac... | Immunological nature of the inhibition of BLV-induced early polykaryocytosis by bovine sera. A quantitative in vitro assay (EPI) was developed for the serological detection of bovine leukemia virus (BLV) infection in cattle. Positive sera inhibit early polykaryocytosis (EP) induced by BLV. We report herein experiments ... | [
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PMID:28297 | The dissociation of b-TSH. The effect of sodium dodecyl sulfate, pH, urea and temperature. | In the present study SDS polyacrylamide gel electrophoresis was used to reinvestigate the conditions under which b-TSH dissociates into its constituent subunits. The effects of SDS, itself, urea, acid pH and temperature were assessed by the decrease in the amount of undissociated TSH and the increase in the dissociated... | The dissociation of b-TSH. The effect of sodium dodecyl sulfate, pH, urea and temperature. In the present study SDS polyacrylamide gel electrophoresis was used to reinvestigate the conditions under which b-TSH dissociates into its constituent subunits. The effects of SDS, itself, urea, acid pH and temperature were asse... | [
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PMID:28300 | Assessment of long-acting neuroleptics. Methods and problems. | Long-acting neuroleptics, without offering a therapeutic breakthrough in the treatment of schizophrenia, are nevertheless a definite step in the management of patients with this disorder. The adequate assessment of these agents necessitates methodological considerations to ensure first, just and adequate patient select... | Assessment of long-acting neuroleptics. Methods and problems. Long-acting neuroleptics, without offering a therapeutic breakthrough in the treatment of schizophrenia, are nevertheless a definite step in the management of patients with this disorder. The adequate assessment of these agents necessitates methodological co... | [
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PMID:28301 | The pH dependency of sodium and chloride transport in the isolated human cornea. | Sodium and chloride net transport in isolated human cornea preparations were found to be pH dependent. Sodium net transport was directed from aqueous humor to tear side at pH 7.6 and 8.6. At pH 7.4, net sodium flux did not differ significantly from zero, and at pH 7.0, net sodium transport was directed toward the aqueo... | The pH dependency of sodium and chloride transport in the isolated human cornea. Sodium and chloride net transport in isolated human cornea preparations were found to be pH dependent. Sodium net transport was directed from aqueous humor to tear side at pH 7.6 and 8.6. At pH 7.4, net sodium flux did not differ significa... | [
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PMID:28307 | Variability of oxygen affinity of normal blood: an automated method of measurement. | Oxygen equilibrium curves of 48 healthy adult subjects have been measured by the method of Rossi-Bernardi et al. (Clin. Chem. 21: 1747, 1975), in which H2O2 is gradually added to a sample of deoxygenated blood that contains an excess of catalase. The mean P50 for nonsmokers was 26.9 Torr and the distribution of values ... | Variability of oxygen affinity of normal blood: an automated method of measurement. Oxygen equilibrium curves of 48 healthy adult subjects have been measured by the method of Rossi-Bernardi et al. (Clin. Chem. 21: 1747, 1975), in which H2O2 is gradually added to a sample of deoxygenated blood that contains an excess of... | [
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PMID:28308 | Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle. | We studied the reactions of human tracheal and bronchial smooth muscle and canine trachealis muscle to adrenergic agonists. Human tissue was obtained from recent autopsies of patients with normal lungs and patients with respiratory disorders, and canine tissue was obtained from animals used in other experiments. The mu... | Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle. We studied the reactions of human tracheal and bronchial smooth muscle and canine trachealis muscle to adrenergic agonists. Human tissue was obtained from recent autopsies of patients with normal lungs and patients with respiratory dis... | [
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PMID:28309 | Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. | The activity of rapamycin, a new anti-Candida antibiotic, was not affected by pH values between 6 and 8; at pH 4, however, activity was abolished. The MIC of rapamycin did not vary drastically with the size of inoculum: a ten-fold dilution of the inoculum reduced the MIC only two-fold. Serum binding was extensive. Seru... | Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. The activity of rapamycin, a new anti-Candida antibiotic, was not affected by pH values between 6 and 8; at pH 4, however, activity was abolished. The MIC of rapamycin did not vary drastically with the size of inoculum: a ten-fold... | [
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PMID:28310 | Specificity and regulation of gamma-aminobutyrate transport in Escherichia coli. | A specific gamma-aminobutyrate (GABA) transport system in Escherichia coli K-12 cells with a K(m) of 12 muM and a V(max) of 278 nmol/ml of intracellular water per min is described. Membrane vesicles contained d-lactate-dependent activity of the system. Mutants defective in GABA transport were isolated; they lost the ab... | Specificity and regulation of gamma-aminobutyrate transport in Escherichia coli. A specific gamma-aminobutyrate (GABA) transport system in Escherichia coli K-12 cells with a K(m) of 12 muM and a V(max) of 278 nmol/ml of intracellular water per min is described. Membrane vesicles contained d-lactate-dependent activity o... | [
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PMID:28311 | Structural basis of the thermostability of monomeric malate synthase from a thermophilic Bacillus. | Malate synthases from a thermophilic Bacillus and Escherichia coli have been isolated in a high state of purity. Molecular weights of these two proteins determined in the native state and after denaturation in sodium dodecyl sulfate-mercaptoethanol show that the enzymes are monomeric. This conclusion is supported, for ... | Structural basis of the thermostability of monomeric malate synthase from a thermophilic Bacillus. Malate synthases from a thermophilic Bacillus and Escherichia coli have been isolated in a high state of purity. Molecular weights of these two proteins determined in the native state and after denaturation in sodium dode... | [
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PMID:28312 | High-dose benzodiazepines in the treatment of severe neurotic anxiety. | There has been a paucity of research in the use of high-dose benzodiazepines in the treatment of severe neurotic anxiety. The author presents five cases, three with excellent and two with poor outcomes. The English and Fench language literature is reviewed and reveals evidence that high-dose benzodiazepines may be usef... | High-dose benzodiazepines in the treatment of severe neurotic anxiety. There has been a paucity of research in the use of high-dose benzodiazepines in the treatment of severe neurotic anxiety. The author presents five cases, three with excellent and two with poor outcomes. The English and Fench language literature is r... | [
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PMID:28313 | Multi-clinic double-blind comparison of triazolam (Halcion) and placebo administered for 14 consecutive nights in outpatients with insomnia. | In this multi-clinic double-blind study, patients suffering from insomnia were treated with triazolam 0.5 mg (Halcion) or placebo for 14 days. Four investigators treated 239 patients, 122 on triazolam and 117 on placebo. Thirty-nine patients, 10 on triazolam and 29 on placebo, dropped out for ineffectiveness of the med... | Multi-clinic double-blind comparison of triazolam (Halcion) and placebo administered for 14 consecutive nights in outpatients with insomnia. In this multi-clinic double-blind study, patients suffering from insomnia were treated with triazolam 0.5 mg (Halcion) or placebo for 14 days. Four investigators treated 239 patie... | [
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PMID:28314 | A microelectronic pH sensor. | This paper presents preliminary data on a new integrated circuit microelectronic pH sensor. The device is extremely miniaturized by the use of integrated circuit technology, and uses the intrinsic hydrogen ion selective properties of the gate insulator material. In order to make the device compatible with aqueous solut... | A microelectronic pH sensor. This paper presents preliminary data on a new integrated circuit microelectronic pH sensor. The device is extremely miniaturized by the use of integrated circuit technology, and uses the intrinsic hydrogen ion selective properties of the gate insulator material. In order to make the device ... | [
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PMID:28315 | Fabrication of pH-sensitive implantable electrode by thick film hybrid technology. | We report preliminary results of our experiments directed at fabricating pH-sensitive electrodes suitable for in vivo use by means of thick film screening techniques. Our results show that glass membranes of suitable thickness and possessing nearly theoretical sensitivity to pH can be fabricated by this process. A hybr... | Fabrication of pH-sensitive implantable electrode by thick film hybrid technology. We report preliminary results of our experiments directed at fabricating pH-sensitive electrodes suitable for in vivo use by means of thick film screening techniques. Our results show that glass membranes of suitable thickness and posses... | [
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PMID:28317 | Use of enzymolysis techniques in studying the mechanical properties of connective tissue components. | The optimum conditions for the selective removal of elastin from connective tissues are described. The process, elastolysis, consists of incubating small samples of connective tissue in buffered saline at ph=8.6 containing 300 microgram/me of a 50-50% mixture of elastase with trypsin inhibitor, for 5-6 hours at room te... | Use of enzymolysis techniques in studying the mechanical properties of connective tissue components. The optimum conditions for the selective removal of elastin from connective tissues are described. The process, elastolysis, consists of incubating small samples of connective tissue in buffered saline at ph=8.6 contain... | [
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PMID:28318 | Diffusion of fluoride ions in dental enamel at pH 7. | The penetration and uptake of both radioactive (18F) and stable fluoride (19F) in bovine enamel were investigated. Buffered pH 7 NaF solutions were employed. Penetration profiles of both 18F and 19F in enamel were determined by using a sectioning technique. 18F and 19F concentrations decreased exponentially with increa... | Diffusion of fluoride ions in dental enamel at pH 7. The penetration and uptake of both radioactive (18F) and stable fluoride (19F) in bovine enamel were investigated. Buffered pH 7 NaF solutions were employed. Penetration profiles of both 18F and 19F in enamel were determined by using a sectioning technique. 18F and 1... | [
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PMID:28319 | Characterization of ionomycin as a calcium ionophore. | The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of extracting calcium ion from the bulk of an aqueous phase into an organic phase. The antibiotic also acts as a mobile ion carrier to transport the cation across a solvent barrier. The divalent cat... | Characterization of ionomycin as a calcium ionophore. The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of extracting calcium ion from the bulk of an aqueous phase into an organic phase. The antibiotic also acts as a mobile ion carrier to transport... | [
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PMID:28320 | Evidence for thyroid hormone-dependent and independent glucocorticoid actions in cultured cells. Studies on the induction of growth hormone and glutamine synthetase in GH1 cells and tyrosine aminotransferase in Reuber H-35 cells. | The induction of growth hormone synthesis and mRNA by thyroid hormone in cultured GH1 cells is mediated by the thyroid hormone nuclear receptor. In addition, the regulation of the growth hormone response by glucocorticoid is highly dependent on the action of thyroid hormone. To clarify whether thyroid hormone has a gen... | Evidence for thyroid hormone-dependent and independent glucocorticoid actions in cultured cells. Studies on the induction of growth hormone and glutamine synthetase in GH1 cells and tyrosine aminotransferase in Reuber H-35 cells. The induction of growth hormone synthesis and mRNA by thyroid hormone in cultured GH1 cell... | [
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PMID:28321 | Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney. | Prolylcarboxypeptidase was purified from human kidney 1200-fold with 18% yield. The enzyme had no cathepsin A activity and appeared to be homogeneous in gel electrophoresis. The molecular weight of prolylcarboxypeptidase was estimated to be 115,000 by gel filtration. Under denaturing conditions the enzyme dissociated i... | Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney. Prolylcarboxypeptidase was purified from human kidney 1200-fold with 18% yield. The enzyme had no cathepsin A activity and appeared to be homogeneous in gel electrophoresis. The molecular weight of prolylcarboxypeptidase was est... | [
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PMID:28325 | Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells. | In certain lines of hepatoma tissue culture (HTC) cells, glutamine synthetase (EC 6.3.1.2) specific activity is increased 2.5- to 3-fold by the addition of glucocorticoids to the growth media. Actinomycin D blocks both the induction and deinduction of glutamine synthetase by glucocorticoids, suggesting a requirement of... | Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells. In certain lines of hepatoma tissue culture (HTC) cells, glutamine synthetase (EC 6.3.1.2) specific activity is increased 2.5- to 3-fold by the addition of glucocorticoids to the growth media. Actinomycin D blocks both the induction a... | [
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PMID:28326 | Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. | Homogeneous wild type and feedback-resistant forms of the biosynthetic sn-glycerol 3-phosphate (glycerol-P) dehydrogenase of Escherichia coli (EC1.1.1.8) were subjected to two-substrate kinetic analysis. The kinetics of the NADPH-dependent reduction of dihydroxyacetone phosphate (dihydroxyacetone-P) and of the NADP-dep... | Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. Homogeneous wild type and feedback-resistant forms of the biosynthetic sn-glycerol 3-phosphate (glycerol... | [
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PMID:28329 | Bovine thymus poly(adenosine diphosphate ribose) polymerase. | About 1,300-fold purification of poly(adenosine diphosphate ribose) polymerase has been achieved from the extract of bovine thymus with a recovery of 10 to 20%. The final preparation has a purity of 99%, and the enzyme is composed of a single peptide with a molecular weight of 130,000. The purified enzyme required NAD+... | Bovine thymus poly(adenosine diphosphate ribose) polymerase. About 1,300-fold purification of poly(adenosine diphosphate ribose) polymerase has been achieved from the extract of bovine thymus with a recovery of 10 to 20%. The final preparation has a purity of 99%, and the enzyme is composed of a single peptide with a m... | [
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PMID:28332 | Actin filament destruction by osmium tetroxide. | We have studied the destruction of purified muscle actin filaments by osmium tetroxide (OsO4) to develop methods to preserve actin filaments during preparation for electron microscopy. Actin filaments are fragmented during exposure to OsO4. This causes the viscosity of solutions of actin filaments to decrease, ultimate... | Actin filament destruction by osmium tetroxide. We have studied the destruction of purified muscle actin filaments by osmium tetroxide (OsO4) to develop methods to preserve actin filaments during preparation for electron microscopy. Actin filaments are fragmented during exposure to OsO4. This causes the viscosity of so... | [
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PMID:28335 | Interference in word associations in schizophrenia. | Assessed the effect of response interference on the word associations of male and female process and reactive schizophrenics in two studies that used the difference in associative disturbances between high and low interference (low and high commonality stimulus words) as the measure. The reactives showed a significantl... | Interference in word associations in schizophrenia. Assessed the effect of response interference on the word associations of male and female process and reactive schizophrenics in two studies that used the difference in associative disturbances between high and low interference (low and high commonality stimulus words)... | [
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PMID:28336 | Psychophysiological responses to presentation of a caged snake among behaviorally avoidant and non-avoidant college students. | Sixty-six coeds who reported fear of snakes on a paper-and-pencil fear inventory were exposed to a Physiological Response Test, during which their electrodermal and cardiac responses to a neutral stimulus and a caged snake were recorded. Half of these coeds then were exposed to a representative Behavioral Avoidance Tes... | Psychophysiological responses to presentation of a caged snake among behaviorally avoidant and non-avoidant college students. Sixty-six coeds who reported fear of snakes on a paper-and-pencil fear inventory were exposed to a Physiological Response Test, during which their electrodermal and cardiac responses to a neutra... | [
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PMID:28337 | Facilitating and debilitating test anxiety among college students and volunteers for desensitization workshops. | Administered the Alpert-Haber Achievement Anxiety Test (AAT) to 54 students who expressed interest in participating in a test anxiety desensitization workshop. In addition, 182 students from the general college population were tested. Results indicated that both the debilitating and facilitating (AAT) scales were highe... | Facilitating and debilitating test anxiety among college students and volunteers for desensitization workshops. Administered the Alpert-Haber Achievement Anxiety Test (AAT) to 54 students who expressed interest in participating in a test anxiety desensitization workshop. In addition, 182 students from the general colle... | [
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PMID:28339 | Reduction in enamel dissolution by liquorice and glycyrrhizinic acid. | Liquorice extracts and confections reduced enamel dissolution in acidic buffers and saliva/glucose incubations by a direct effect on solubility, and by inhibiting the fall in pH on incubation. These actions may be attributed to the solubility-reducing, glycolysis-inhibiting, and buffering properties of glycyrrhizinic a... | Reduction in enamel dissolution by liquorice and glycyrrhizinic acid. Liquorice extracts and confections reduced enamel dissolution in acidic buffers and saliva/glucose incubations by a direct effect on solubility, and by inhibiting the fall in pH on incubation. These actions may be attributed to the solubility-reducin... | [
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PMID:28340 | An electrochemical study on the human dental enamel with special reference to isoelectric point. | In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming potential method. As a result, these isoelectric points could be decided. | An electrochemical study on the human dental enamel with special reference to isoelectric point. In an attempt to make a dynamic study of the isoelectric point and the chargeability of human dental enamel, an electrochemical approach was utilized. Zeta potential of three kinds of the enamel was measured by a streaming ... | [
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PMID:28341 | Effect of 4.5--year use of xylitol and sorbitol on plaque. | The pH values of xylitol-containing plaque suspensions of persons who habitually used xylitol and sorbitol during 3.2 to 4.5 years did not significantly differ from those observed with suspensions containing no added carbohydrates. Sorbitol produced in 22-hour incubations pH values as low as 3.9 to 5.5. The activity of... | Effect of 4.5--year use of xylitol and sorbitol on plaque. The pH values of xylitol-containing plaque suspensions of persons who habitually used xylitol and sorbitol during 3.2 to 4.5 years did not significantly differ from those observed with suspensions containing no added carbohydrates. Sorbitol produced in 22-hour ... | [
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PMID:28342 | Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa. | Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/or 4-androstenedione in vitro, acted as a compe... | Effect of progestins on androgen delta4-3-ketosteroid-5alpha-A-ring reductase system in rat oral mucosa. Rat oral mucosa microsomal delta4-3-ketosteroid-5alpha-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate... | [
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PMID:28343 | Child abuse and dentistry: orofacial trauma and its recognition by dentists. | Orofacial trauma was found in 49% of 260 documented cases of child abuse seen during of five-year period at the Children's Hospital Medical Center, Boston. An additional 16% of the cases involved head trauma; the total percentage of head and facial trauma was 65%. Head or facial trauma was the principal reason for admi... | Child abuse and dentistry: orofacial trauma and its recognition by dentists. Orofacial trauma was found in 49% of 260 documented cases of child abuse seen during of five-year period at the Children's Hospital Medical Center, Boston. An additional 16% of the cases involved head trauma; the total percentage of head and f... | [
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PMID:28346 | [A new instrument for measurement of actual instantaneous pH in obstetric (author's transl)]. | The authors present a new instrument for measurement of actual instantaneous pH in obstetrics. It has been developped to avoid most errors of the usual scalp-blood sampling. Its advantages are:--Aspiration is manual and controlled.--Results are obtained within 10--15 seconds. A comparative study with two other pH-meter... | [A new instrument for measurement of actual instantaneous pH in obstetric (author's transl)]. The authors present a new instrument for measurement of actual instantaneous pH in obstetrics. It has been developped to avoid most errors of the usual scalp-blood sampling. Its advantages are:--Aspiration is manual and contro... | [
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PMID:28350 | Polyarteritis: A cause of nerve palsy in the extremity. | The association between polyarteritis and peripheral neuropathy may be overlooked in the clinical assessment of nerve lesions in the extremity. Nerve palsy may be the initial presenting complaint in polyarteritis nodosa. A case is presented which demonstrates the pathological process. A method for early recognition and... | Polyarteritis: A cause of nerve palsy in the extremity. The association between polyarteritis and peripheral neuropathy may be overlooked in the clinical assessment of nerve lesions in the extremity. Nerve palsy may be the initial presenting complaint in polyarteritis nodosa. A case is presented which demonstrates the ... | [
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PMID:28369 | Low molecular weight C1q-precipitins in hypocomplementemic vasculitis-urticaria syndrome: partial purification and characterization as immunoglobulin. | A lupus-like syndrome involving chronic urticaria with cutaneous vasculitis, systemic symptoms, hypocomplementemia with preferential depletion of C1q, and low m.w. (7S) C1q-precipitins has recently been defined. The C1q-precipitin activity (C1q-p) seems to represent a diagnostic marker of the disease, but its chemical ... | Low molecular weight C1q-precipitins in hypocomplementemic vasculitis-urticaria syndrome: partial purification and characterization as immunoglobulin. A lupus-like syndrome involving chronic urticaria with cutaneous vasculitis, systemic symptoms, hypocomplementemia with preferential depletion of C1q, and low m.w. (7S) ... | [
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PMID:28370 | Characterization of human hairbulb tyrosinase: properties of normal and albino enzyme. | Human hairbulb tyrosinase from normally pigmented and tyrosinase-positive oculocutaneous albino (TPA) hairbulbs was studied by single hairbulb and by pooled hairbulb assay procedures. The response to temperature and pH was the same for TPA and normal enzyme. The Km for tyrosine as substrate and the Km or dopa as cofact... | Characterization of human hairbulb tyrosinase: properties of normal and albino enzyme. Human hairbulb tyrosinase from normally pigmented and tyrosinase-positive oculocutaneous albino (TPA) hairbulbs was studied by single hairbulb and by pooled hairbulb assay procedures. The response to temperature and pH was the same f... | [
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PMID:28372 | Endogenous angiotensin I concentration in human plasma. | A reliable radioimmunoassay of endogenous angiotensin I concentration in plasma, extracted on a Dowex-resin at pH 7.4, is described. The concentration of angiotensin I in the pH 7.4-extracted plasma samples is significantly correlated with the angiotensin I concentration in the samples extracted at pH 5.5, the pH optim... | Endogenous angiotensin I concentration in human plasma. A reliable radioimmunoassay of endogenous angiotensin I concentration in plasma, extracted on a Dowex-resin at pH 7.4, is described. The concentration of angiotensin I in the pH 7.4-extracted plasma samples is significantly correlated with the angiotensin I concen... | [
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PMID:28373 | Supersaturation of urine with uric acid and urate: response to a uricosuric diuretic. | In order to assess the possibility that treatment with the uricosuric diuretic ticrynafen (tienilic acid) could lead to UA or MSU crystalluria, the degree of urinary supersaturation with respect to these crystalloids was assessed in persons receiving the diuretic for 1 week, and the results were compared with similar d... | Supersaturation of urine with uric acid and urate: response to a uricosuric diuretic. In order to assess the possibility that treatment with the uricosuric diuretic ticrynafen (tienilic acid) could lead to UA or MSU crystalluria, the degree of urinary supersaturation with respect to these crystalloids was assessed in p... | [
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PMID:28376 | Renal regulation of acid-base balance in a freshwater fish (1). | Intra-arterial injection of a fixed acid load caused only a short-lived (less than 2h) disturbance of blood pH but a long lived (2-3 days) elevation of urinary acid excretion in freshwater trout (Salmo gairdneri). The renal response comprised an immediate increase in acid output in the form of titratable acidity minus ... | Renal regulation of acid-base balance in a freshwater fish (1). Intra-arterial injection of a fixed acid load caused only a short-lived (less than 2h) disturbance of blood pH but a long lived (2-3 days) elevation of urinary acid excretion in freshwater trout (Salmo gairdneri). The renal response comprised an immediate ... | [
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PMID:28377 | The isolation of a Bwamba virus variant from man in Western Kenya. | A bwamba group virus was isolated from the blood of a febrile child on the Kano Plain, Kenya. The isolate (NY-45), closely resembling Bwamba, established infection in both Anopheles gambiae and Mansonia uniformis. Neither the Bwamba nor the Pongola prototype strains grew in both species. In gel-diffusion tests NY-45 vi... | The isolation of a Bwamba virus variant from man in Western Kenya. A bwamba group virus was isolated from the blood of a febrile child on the Kano Plain, Kenya. The isolate (NY-45), closely resembling Bwamba, established infection in both Anopheles gambiae and Mansonia uniformis. Neither the Bwamba nor the Pongola prot... | [
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PMID:28378 | Effect of a new benzodiazepine bromazepam on locomotor performance and brain monoamine metabolism. | Administration of a single dose (10 mg/kg) of a relatively new benzodiazepine, bromazepam to rats markedly suppressed their spontaneous locomotor activity. Hypomobility became apparent 15 min after the injection and remained significantly lower during the period of observation for 6 hours when locomotor activity was 27... | Effect of a new benzodiazepine bromazepam on locomotor performance and brain monoamine metabolism. Administration of a single dose (10 mg/kg) of a relatively new benzodiazepine, bromazepam to rats markedly suppressed their spontaneous locomotor activity. Hypomobility became apparent 15 min after the injection and remai... | [
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... |
PMID:28379 | Biosynthesis and processing of presumed neurosecretory proteins in single identified neurons of Aplysia californica. | The biosynthesis and processing of low molecular weight protein (presumed neurosecretory protein) in cells R15, R14 and L11 of Aplysia californica was studied at high resolution by polyacrylamide slab gel electrophoresis in sodium dodecylsulfate. The number of low molecular weight proteins detected in each cell ranges ... | Biosynthesis and processing of presumed neurosecretory proteins in single identified neurons of Aplysia californica. The biosynthesis and processing of low molecular weight protein (presumed neurosecretory protein) in cells R15, R14 and L11 of Aplysia californica was studied at high resolution by polyacrylamide slab ge... | [
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0.056... |
PMID:28387 | Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease. | In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that cholinergic rather than dopaminergic mechanisms are more important in the control of swallowing in... | Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease. In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that c... | [
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0.0387... |
PMID:28388 | Radioiodinated derivatives of beta adrenoceptor blockers for myocardial imaging. | Four new beta-adrenoceptor blocking agents carrying tyramine as the amino moiety were synthesized and the distribution of their I-125-tagged derivatives evaluated in rats. This distribution was compared with the distribution of various agonists and antagonists labeled with H-3 and C-14, and with the in vitro binding af... | Radioiodinated derivatives of beta adrenoceptor blockers for myocardial imaging. Four new beta-adrenoceptor blocking agents carrying tyramine as the amino moiety were synthesized and the distribution of their I-125-tagged derivatives evaluated in rats. This distribution was compared with the distribution of various ago... | [
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PMID:28389 | Experimental cross infections of Fasciola hepatica in lambs and calves. | The effects of experimental infections with Fasciola hepatica of ovine and bovine origin in homologous and heterologous hosts and in uninfected controls were compared; groups comprised 5 animals each. The effects of the infections were monitored by biweekly determinations of packed cell volumes (PCV), serum glutamic ox... | Experimental cross infections of Fasciola hepatica in lambs and calves. The effects of experimental infections with Fasciola hepatica of ovine and bovine origin in homologous and heterologous hosts and in uninfected controls were compared; groups comprised 5 animals each. The effects of the infections were monitored by... | [
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