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PMID:29020 | NADP-dependent dehydrogenases in rat liver parenchyma. I. Methodological studies on the qualitative histochemistry of G6PDH, 6PGDH, malic enzyme and ICDH. | At present soluble NADP-dependent dehydrogenases are histochemically demonstrated in three different ways: according to the standard method incubation in aqueous media leads to the precipitation of formazan, the formation of which depends entirely on the presence of endogeneous NADPH2-tetrazolium reductases. With the t... | NADP-dependent dehydrogenases in rat liver parenchyma. I. Methodological studies on the qualitative histochemistry of G6PDH, 6PGDH, malic enzyme and ICDH. At present soluble NADP-dependent dehydrogenases are histochemically demonstrated in three different ways: according to the standard method incubation in aqueous med... | [
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PMID:29021 | Isoelectric focusing studies on the neutral 5'-nucleotidase from Wistar rat hippocampus: evidence for the absence of isoenzymes. | The pattern and some substrates characteristic of the rat brain 5'-nucleotidase were studied using the isoelectric focusing technique, which revealed that the enzyme is present in a single form in hippocampus extracts. An alkaline phosphatase, which is also able to split nucleoside monophosphates, is not active at neut... | Isoelectric focusing studies on the neutral 5'-nucleotidase from Wistar rat hippocampus: evidence for the absence of isoenzymes. The pattern and some substrates characteristic of the rat brain 5'-nucleotidase were studied using the isoelectric focusing technique, which revealed that the enzyme is present in a single fo... | [
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PMID:29022 | Improved localization of thiamine pyrophosphatase activity in mounted cryostat sections using gel fixation and gel incubation media. | The presence of 1% agar in the fixation and substrate solutions for the histochemical demonstration of thiamine pyrophosphatase (4.4 mM TPP; 3.6 mM Pb2+; 0.025 Tris-maleate buffer, pH 7.2) clearly facilitates the localization of the enzyme in Golgi apparatus in cold microtome sections prepared from unfixed specimens. | Improved localization of thiamine pyrophosphatase activity in mounted cryostat sections using gel fixation and gel incubation media. The presence of 1% agar in the fixation and substrate solutions for the histochemical demonstration of thiamine pyrophosphatase (4.4 mM TPP; 3.6 mM Pb2+; 0.025 Tris-maleate buffer, pH 7.2... | [
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PMID:29023 | Differentiation of two types of endocrine cells which take up amine precursors using their capacity to take up the fluorescent dihydroisoquinoline derivative of dopamine. | A study was made of the accumulation of the strongly fluorescent 2-carboxymethyl-6,7-dihydroxy-3,4-dihydroisoquinolinium compound (2-Carb. Me-DIQ) derived from the condensation reaction of dopamine with glyoxylic acid in endocrine cells possessing the capacity to take up and store biogenic monoamine precursors. Thin-la... | Differentiation of two types of endocrine cells which take up amine precursors using their capacity to take up the fluorescent dihydroisoquinoline derivative of dopamine. A study was made of the accumulation of the strongly fluorescent 2-carboxymethyl-6,7-dihydroxy-3,4-dihydroisoquinolinium compound (2-Carb. Me-DIQ) de... | [
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PMID:29024 | Determination of the metabolites of bezitramide in urine. II. The basic metabolite. | A high-performance liquid chromatographic method for the determination of low levels (less than 1 microgram/ml) of the basic metabolite of bezitramide, 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, in human urine is described. Special attention is given to the separation from the basic metabolite of droperidol, ... | Determination of the metabolites of bezitramide in urine. II. The basic metabolite. A high-performance liquid chromatographic method for the determination of low levels (less than 1 microgram/ml) of the basic metabolite of bezitramide, 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one, in human urine is described. Sp... | [
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PMID:29030 | Prevalence of self-injurious behaviors in a large state facility for the retarded: a three-year follow-up study. | A combined informant questionnaire and interview survey of self-injurious behavior (SIB) at a large state facility for the retarded was conducted independently three times over a 3-year period. Prevalence consistently was about 10% of the population. SIB cases tended to be younger and institutionalized longer than the ... | Prevalence of self-injurious behaviors in a large state facility for the retarded: a three-year follow-up study. A combined informant questionnaire and interview survey of self-injurious behavior (SIB) at a large state facility for the retarded was conducted independently three times over a 3-year period. Prevalence co... | [
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PMID:29031 | Autolysins and shape change in rodA mutants of Bacillus subtilis. | The biochemical phenotype of rodA mutants was not affected by the simultaneous presence in double mutants of the lyt gene which makes them 90 to 95% deficient in autolysin action. The only morphological effect of this deficiency on the expression of the rod gene was that both the rod and the coccal forms of the mutant ... | Autolysins and shape change in rodA mutants of Bacillus subtilis. The biochemical phenotype of rodA mutants was not affected by the simultaneous presence in double mutants of the lyt gene which makes them 90 to 95% deficient in autolysin action. The only morphological effect of this deficiency on the expression of the ... | [
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PMID:29032 | ATP activation and properties of the methyl coenzyme M reductase system in Methanobacterium thermoautotrophicum. | The requirement of ATP for the methyl coenzyme M methylreductase in extracts of Methanobacterium thermoautotrophicum was found to be catalytic; for each mol of ATP added, 15 mol of methane was produced from methyl coenzyme M [2-(methylthio)ethanesulfonic acid]. Other nucleotide triphosphates partially replaced ATP in a... | ATP activation and properties of the methyl coenzyme M reductase system in Methanobacterium thermoautotrophicum. The requirement of ATP for the methyl coenzyme M methylreductase in extracts of Methanobacterium thermoautotrophicum was found to be catalytic; for each mol of ATP added, 15 mol of methane was produced from ... | [
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PMID:29033 | Psychoactive drug interactions. | Interactions can arise from serial or simultaneous administration of 2 or more drugs. Interactions with other medications can enhance or diminish either the clinical usefulness of a drug, or its toxic effects. Interactions can arise from changes in absorption, protein binding, metabolism, excretion or activity at a com... | Psychoactive drug interactions. Interactions can arise from serial or simultaneous administration of 2 or more drugs. Interactions with other medications can enhance or diminish either the clinical usefulness of a drug, or its toxic effects. Interactions can arise from changes in absorption, protein binding, metabolism... | [
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PMID:29034 | Phosphorus nuclear magnetic resonance studies of phosphorus metabolites in frog muscle. | 31P-nuclear magnetic resonance was applied to living muscles of bullfrogs, and the time courses of metabolic changes of ATP, creatine phosphate, inorganic phosphate, and sugar phosphates were studied under anaerobic and aerobic conditions. A decrease in creatine phosphate was observed in the resting muscle under anaero... | Phosphorus nuclear magnetic resonance studies of phosphorus metabolites in frog muscle. 31P-nuclear magnetic resonance was applied to living muscles of bullfrogs, and the time courses of metabolic changes of ATP, creatine phosphate, inorganic phosphate, and sugar phosphates were studied under anaerobic and aerobic cond... | [
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PMID:29036 | Purification and some properties of a specific nuclease which cleaves transfer RNA precursors from the posterior silk gland of Bombyx mori. | A specific endonuclease involved in the processing of tRNA precursors was isolated and partially purified from the posterior silk gland of Bombyx mori, and designated as RNase P.Bmo. This enzyme was shown to catalyze the conversion of 4.5 S precursor RNA to 4.1 S RNA by trimming the 5'-additional segment from the precu... | Purification and some properties of a specific nuclease which cleaves transfer RNA precursors from the posterior silk gland of Bombyx mori. A specific endonuclease involved in the processing of tRNA precursors was isolated and partially purified from the posterior silk gland of Bombyx mori, and designated as RNase P.Bm... | [
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PMID:29037 | Purification and properties of acetate kinase from Bacillus stearothermophilus. | 1. Acetate kinase [EC 2.7.2.1] from an thermophile, B. stearothermophilus, was purified and crystalized. 2. This enzyme was shown to be a tetramer of identical subunits which had a molecular weight of about 40,000. Amino acid analysis showed no SH group. By analyzing the CD spectrum it was deduced that this enzyme is c... | Purification and properties of acetate kinase from Bacillus stearothermophilus. 1. Acetate kinase [EC 2.7.2.1] from an thermophile, B. stearothermophilus, was purified and crystalized. 2. This enzyme was shown to be a tetramer of identical subunits which had a molecular weight of about 40,000. Amino acid analysis showe... | [
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PMID:29038 | Studies of a calcium-activated neutral protease from chicken skeletal muscle. I. Purification and characterization. | A calcium-activated neutral protease was purified 2,700-fold over the crude extract from chicken skeletal muscle. The purified protease migrated as a single band on polyacrylamide gel electrophoresis with or without SDS. Its molecular weight was 80,000 and pH optimum for activity was 7.7. The activity required strictly... | Studies of a calcium-activated neutral protease from chicken skeletal muscle. I. Purification and characterization. A calcium-activated neutral protease was purified 2,700-fold over the crude extract from chicken skeletal muscle. The purified protease migrated as a single band on polyacrylamide gel electrophoresis with... | [
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PMID:29039 | Studies on cellulases of a phytopathogenic fungus, Pyricularia oryzae cavara. II. Purification and properties of a beta-glucosidase. | Three components (GA, GB-1, and GB-2) of beta-glucosidase were detected in the culture filtrate of Pyricularia oryzae grown in a cellulose or cellulose derivative medium. Among them, GB-1 was induced most strongly. Purified GB-1 was homogeneous on polyacrylamide gel electrophoresis and showed an approximately 1,400-fol... | Studies on cellulases of a phytopathogenic fungus, Pyricularia oryzae cavara. II. Purification and properties of a beta-glucosidase. Three components (GA, GB-1, and GB-2) of beta-glucosidase were detected in the culture filtrate of Pyricularia oryzae grown in a cellulose or cellulose derivative medium. Among them, GB-1... | [
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PMID:29040 | Pyridine nucleotide interaction with rat liver dihydropteridine reductase. | The interactions of a homogeneous preparation of rat liver dihydropteridine reductase with NADH, NADPH, NAD+, NADP+, and the 1-N6-ethenoadenine derivative of NAD+ have been investigated by fluorescence titration, circular dichroism, equilibrium dialysis, Sephadex G-25 chromatography, and polyacrylamide gel electrophore... | Pyridine nucleotide interaction with rat liver dihydropteridine reductase. The interactions of a homogeneous preparation of rat liver dihydropteridine reductase with NADH, NADPH, NAD+, NADP+, and the 1-N6-ethenoadenine derivative of NAD+ have been investigated by fluorescence titration, circular dichroism, equilibrium ... | [
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PMID:29041 | Membrane bioenergetic parameters in uncoupler-resistant mutants of Bacillus megaterium. | Mutants of Bacillus megaterium displaying malate-driven ATP synthesis resistant to uncouplers of oxidative posphorylation are further characterized. Both the pH gradient and electrical potential generated across the membrane by malate respiration are equally sensitive to uncouplers in the wild type and uncoupler-resist... | Membrane bioenergetic parameters in uncoupler-resistant mutants of Bacillus megaterium. Mutants of Bacillus megaterium displaying malate-driven ATP synthesis resistant to uncouplers of oxidative posphorylation are further characterized. Both the pH gradient and electrical potential generated across the membrane by mala... | [
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PMID:29042 | Subunit interactions of Glycera dibranchiata hemoglobin. | The coelomic cells of the polychaete annelid Glycera dibranchiata contain two hemoglobins. The monomer hemoglobin fraction is composed of one major component and two minor components as determined by starch gel electrophoresis and isoelectrofocusing, but is homogeneous as to subunit size as demonstrated by sodium dodec... | Subunit interactions of Glycera dibranchiata hemoglobin. The coelomic cells of the polychaete annelid Glycera dibranchiata contain two hemoglobins. The monomer hemoglobin fraction is composed of one major component and two minor components as determined by starch gel electrophoresis and isoelectrofocusing, but is homog... | [
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PMID:29046 | A spectral probe near the subunit catalytic site of glutamine synthetase from Escherichia coli. Reduced pyridoxal 5'-phosphate.enzyme complexes. | In order to label phosphate binding sites, unadenylylated glutamine synthetase from Escherichia coli has been pyridoxylated by reacting the enzyme with pyridoxal 5'-phosphate followed by reduction of the Schiff base with NaBH4. A complete loss in Mg2+-supported activity is associated with the incorporation of 3 eq of p... | A spectral probe near the subunit catalytic site of glutamine synthetase from Escherichia coli. Reduced pyridoxal 5'-phosphate.enzyme complexes. In order to label phosphate binding sites, unadenylylated glutamine synthetase from Escherichia coli has been pyridoxylated by reacting the enzyme with pyridoxal 5'-phosphate ... | [
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PMID:29047 | The internal pH of isolated serotonin containing granules of pig platelets. | The [14C]methylamine distribution method was utilized to measure the internal pH of isolated serotonin containing granules of pig blood platelets under varying conditions. The granules used were isolated by a new protocol which stressed platelet rupture under controlled conditions and preservation of isotonicity throug... | The internal pH of isolated serotonin containing granules of pig platelets. The [14C]methylamine distribution method was utilized to measure the internal pH of isolated serotonin containing granules of pig blood platelets under varying conditions. The granules used were isolated by a new protocol which stressed platele... | [
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PMID:29050 | Nonrandom distribution of sialic acid over the cell surface of bristle-coated endocytic vesicles of the sinusoidal endothelium cells. | Previous studies with protein tracers have shown that the luminal surface of the vascular endothelium of the bone marrow is endocytic. The endocytosis occurs through the formation of large bristle-coated vesicles (LCV). The anionic charge distribution in this process was examined at the luminal surface of the endotheli... | Nonrandom distribution of sialic acid over the cell surface of bristle-coated endocytic vesicles of the sinusoidal endothelium cells. Previous studies with protein tracers have shown that the luminal surface of the vascular endothelium of the bone marrow is endocytic. The endocytosis occurs through the formation of lar... | [
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PMID:29051 | Hemagglutination with simian papovavirus SA12. | Simian papovavirus SA12 agglutinated human, guinea pig, and chicken erythrocytes. SA12 hemagglutinin was most effectively released from debris of infected tissue culture cells at an alkaline pH. | Hemagglutination with simian papovavirus SA12. Simian papovavirus SA12 agglutinated human, guinea pig, and chicken erythrocytes. SA12 hemagglutinin was most effectively released from debris of infected tissue culture cells at an alkaline pH. | [
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PMID:29052 | Relationship between the rate of H+ transport and pathways of glucose metabolism by turtle urinary bladder. | The urinary bladder of the fresh-water turtle acidifies its contents by actively transporting H(+) ions across the luminal membrane. It is known that the H(+) transport system is dependent upon oxidative metabolism and the substrate glucose; however, the specific biochemical events resulting in H(+) translocation have ... | Relationship between the rate of H+ transport and pathways of glucose metabolism by turtle urinary bladder. The urinary bladder of the fresh-water turtle acidifies its contents by actively transporting H(+) ions across the luminal membrane. It is known that the H(+) transport system is dependent upon oxidative metaboli... | [
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PMID:29053 | Tissue guanosine-3',5'-cyclic monophosphate levels and soluble guanylate cyclase activity: a positive correlation during unilateral cryptorchidism in the rat testis. | The relationship between the subcellular distribution of guanylate cyclase and tissue guanosine-3',5'-cyclic monophosphate (cGMP) levels was investigated in rat testes after surgically induced unilateral cryptorchidism. Placement of one of a testis pair in the abdominal cavity results in loss of testicular weight and f... | Tissue guanosine-3',5'-cyclic monophosphate levels and soluble guanylate cyclase activity: a positive correlation during unilateral cryptorchidism in the rat testis. The relationship between the subcellular distribution of guanylate cyclase and tissue guanosine-3',5'-cyclic monophosphate (cGMP) levels was investigated ... | [
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PMID:29054 | Human llamas: adaptation to altitude in subjects with high hemoglobin oxygen affinity. | To assess the adaptive value of the right-shift of the oxyhemoglobin dissociation curve (decreased affinity for oxygen) observed in humans upon altitude exposure, the short-term physiologic responses to altitude-induced hypoxia were evaluated in two subjects with a high oxygen affinity hemoglobin (Hb Andrew-Minneapolis... | Human llamas: adaptation to altitude in subjects with high hemoglobin oxygen affinity. To assess the adaptive value of the right-shift of the oxyhemoglobin dissociation curve (decreased affinity for oxygen) observed in humans upon altitude exposure, the short-term physiologic responses to altitude-induced hypoxia were ... | [
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PMID:29055 | Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. | Isolated rat lungs were ventilated with air and perfused with a blood-free Krebs-Ringer bicarbonate solution under conditions of net CO2 elimination in the lung. Some of the effluent perfusate was drawn through a stop-flow pH electrode apparatus, arriving at the electrode within 4 s after passing through the pulmonary ... | Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. Isolated rat lungs were ventilated with air and perfused with a blood-free Krebs-Ringer bicarbonate solution under conditions of net CO2 elimination in the lung. Some of the effluent perfusate was drawn through a stop-flow pH electrode ap... | [
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PMID:29056 | Hereditary male pseudohermaphroditism associated with an unstable form of 5 alpha-reductase. | The properties of 5alpha-reductase have been compared in genital skin fibroblasts cultured from five patients from three families (Los Angeles, Dallas, and Dominican Republic) in which hereditary male pseudohermaphroditism has been established to result from deficient conversion of testosterone to dihydrotestosterone. ... | Hereditary male pseudohermaphroditism associated with an unstable form of 5 alpha-reductase. The properties of 5alpha-reductase have been compared in genital skin fibroblasts cultured from five patients from three families (Los Angeles, Dallas, and Dominican Republic) in which hereditary male pseudohermaphroditism has ... | [
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PMID:29057 | Taped vs. "live" desensitization and level of autonomic arousal. | Investigated whether variations in method of presentation of anxiety items (Es voice, E's taped voice, S's taped voice) will result in differences in autonomic arousal (as measured by self-report, galvanic skin responses, cardiac rate, blood pressure). Ss were 24 Naval Academy midshipmen. The procedure involved (1) tra... | Taped vs. "live" desensitization and level of autonomic arousal. Investigated whether variations in method of presentation of anxiety items (Es voice, E's taped voice, S's taped voice) will result in differences in autonomic arousal (as measured by self-report, galvanic skin responses, cardiac rate, blood pressure). Ss... | [
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PMID:29060 | Neuroleptic-induced attenuation of brain stimulation reward in rats. | In 30-min free-operant tests, the dopamine receptor blockers pimozide (.125, .25, and .50 mg/kg) and (+)-butaclamol (.1, .2, and .4 mg/kg) attenuated lever pressing for lateral hypothalamic brain stimulation. When discrete self-stimulation trials were offered in a straight alleyway, pimozide increased start box latenci... | Neuroleptic-induced attenuation of brain stimulation reward in rats. In 30-min free-operant tests, the dopamine receptor blockers pimozide (.125, .25, and .50 mg/kg) and (+)-butaclamol (.1, .2, and .4 mg/kg) attenuated lever pressing for lateral hypothalamic brain stimulation. When discrete self-stimulation trials were... | [
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PMID:29058 | Effect of abdominal radiation therapy on drug absorption in humans. | The absorption of oral digoxin and of desmethyldiazepam, from its precursor clorazepate, was studied in seven patients who had received abdominal and/or pelvic radiation therapy for neoplastic disease. All patients were in remission and had normal renal function and no evidence of malabsorption. Single 0.5-mg doses of ... | Effect of abdominal radiation therapy on drug absorption in humans. The absorption of oral digoxin and of desmethyldiazepam, from its precursor clorazepate, was studied in seven patients who had received abdominal and/or pelvic radiation therapy for neoplastic disease. All patients were in remission and had normal rena... | [
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PMID:29068 | Selective sensitivity to hydrocortisone of regulatory functions that determine the magnitude of the antibody response to type III pneumococcal polysaccharide. | Previous studies on the basis for the immunosuppressive potential of adrenal corticosteroids have stressed that the effects of these agents on immune functions depend on the animal species being considered, as well as the subpopulations of lymphocytes involved in the expression of immune functions examined. In the pres... | Selective sensitivity to hydrocortisone of regulatory functions that determine the magnitude of the antibody response to type III pneumococcal polysaccharide. Previous studies on the basis for the immunosuppressive potential of adrenal corticosteroids have stressed that the effects of these agents on immune functions d... | [
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PMID:29075 | Hepatic lipid metabolism. Age-related changes in triglyceride metabolism. | Age-related changes in hepatic triglyceride formation have been described in developing rats. Triglyceride formation was measured in vitro in the presence of [14C]glycerol-3-phosphate, palmitate, ATP, CoA, and Mg2+ by using liver homogenates and microsomal fractions derived from various age groups of animals. Triglycer... | Hepatic lipid metabolism. Age-related changes in triglyceride metabolism. Age-related changes in hepatic triglyceride formation have been described in developing rats. Triglyceride formation was measured in vitro in the presence of [14C]glycerol-3-phosphate, palmitate, ATP, CoA, and Mg2+ by using liver homogenates and ... | [
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PMID:29076 | R-factor mediated dihydrofolate reductases which confer trimethoprim resistance. | Six different R-factors conferring trimethoprim resistance had been isolated from a variety of sources. The trimethoprim-resistant dihydrofolate reductases (EC 1.5.1.3) from strains containing these R-factors were purified by ammonium sulphate precipitation and DEAE-cellulose ion-exchange chromatography. The enzymes sh... | R-factor mediated dihydrofolate reductases which confer trimethoprim resistance. Six different R-factors conferring trimethoprim resistance had been isolated from a variety of sources. The trimethoprim-resistant dihydrofolate reductases (EC 1.5.1.3) from strains containing these R-factors were purified by ammonium sulp... | [
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PMID:29077 | An RNA polymerase activity in purified rabies virions. | An RNA polymerase activity has been demonstrated in purified rabies virions. Efficiency of the reaction is low since the rate of incorporation was equal to 3 to 5 pmol of uridine per hour, per mg of protein. As with other mammalian rhabdoviruses the optimal temperature was 31 degrees C. Unlike vesicular stomatitis viru... | An RNA polymerase activity in purified rabies virions. An RNA polymerase activity has been demonstrated in purified rabies virions. Efficiency of the reaction is low since the rate of incorporation was equal to 3 to 5 pmol of uridine per hour, per mg of protein. As with other mammalian rhabdoviruses the optimal tempera... | [
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PMID:29078 | Increase by calcium in production of interferon by L929 cells induced with polyriboinosinate-polyribocytidylate complex. | Calcium chloride (5 to 20 mM) potentiated interferon production induced by rIn:rCn in L929 mouse fibroblasts up to a thousand-fold. Higher concentrations of calcium (20 to 65 mM) mixed with rIn:rCn were associated with increased cytotoxicity and a more acidic medium, but were effective in enhancing interferon productio... | Increase by calcium in production of interferon by L929 cells induced with polyriboinosinate-polyribocytidylate complex. Calcium chloride (5 to 20 mM) potentiated interferon production induced by rIn:rCn in L929 mouse fibroblasts up to a thousand-fold. Higher concentrations of calcium (20 to 65 mM) mixed with rIn:rCn w... | [
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PMID:29079 | Poly (A) polymerase activity in L cells following encephalomyocarditis virus infection. | Poly (A) polymerase activity has been measured in crude cytoplasmic extracts of mouse L cells infected with encephalomyocarditis (EMC) virus. After infection there is first a decrease in enzyme activity followed by an increase which itself precedes detectable virus RNA and protein synthesis. The activity of the enzyme ... | Poly (A) polymerase activity in L cells following encephalomyocarditis virus infection. Poly (A) polymerase activity has been measured in crude cytoplasmic extracts of mouse L cells infected with encephalomyocarditis (EMC) virus. After infection there is first a decrease in enzyme activity followed by an increase which... | [
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PMID:29080 | Cerebral transmitter precursors and metabolites in advanced renal disease. | Patients with chronic renal disease had low plasma total tryptophan but an abnormally high proportion of this was in the free state. The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid. CSF tryptophan correlated better with plasma free than with plasma ... | Cerebral transmitter precursors and metabolites in advanced renal disease. Patients with chronic renal disease had low plasma total tryptophan but an abnormally high proportion of this was in the free state. The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleaceti... | [
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PMID:29081 | Guanylate cyclase activity in normal and diseased human muscle. | Guanylate cyclase activity has been studied in muscle of normal subjects and of patients suffering from muscular and neuromuscular diseases. In normal tissue a guanylate cyclase activity was found in both soluble and particulate fractions of homogenate. We found also that the kinetic analysis of the enzyme of soluble d... | Guanylate cyclase activity in normal and diseased human muscle. Guanylate cyclase activity has been studied in muscle of normal subjects and of patients suffering from muscular and neuromuscular diseases. In normal tissue a guanylate cyclase activity was found in both soluble and particulate fractions of homogenate. We... | [
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PMID:29083 | Neurosurgery: considerations for strength and quality. The 1978 AANS presidential address. | The President of the American Association of Neurological Surgeons reviews the organization of the Association designed to represent neurosurgery and neurosurgeons. He summarizes the pertinent problems that the specialty has faced and with which it continues to deal, in persistent pursuit of its objective: to assure th... | Neurosurgery: considerations for strength and quality. The 1978 AANS presidential address. The President of the American Association of Neurological Surgeons reviews the organization of the Association designed to represent neurosurgery and neurosurgeons. He summarizes the pertinent problems that the specialty has face... | [
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PMID:29085 | Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency disease. | Two patients, one with an autosomal and the other a sex-linked form of severe combined immunodeficiency, had more than 95% B cells in their peripheral blood. Despite an increased absolute number of B lymphocytes, the patients were unable to produce serum antibodies. In each patient, geno- or pheno-identical bone marrow... | Selective defect of precursor T cells associated with apparently normal B lymphocytes in severe combined immunodeficiency disease. Two patients, one with an autosomal and the other a sex-linked form of severe combined immunodeficiency, had more than 95% B cells in their peripheral blood. Despite an increased absolute n... | [
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PMID:29089 | The effect of microcapsule size on the oxidative decomposition of core material. | The factors that affect the size of microcapsules and the oxidation of their benzaldehyde core have been examined. The pH of the preparation changed the overall size of the microcapsules which reached a maximum diameter at pH 4.1. The size of the core droplets also varied with the preparative pH and their oxidation rat... | The effect of microcapsule size on the oxidative decomposition of core material. The factors that affect the size of microcapsules and the oxidation of their benzaldehyde core have been examined. The pH of the preparation changed the overall size of the microcapsules which reached a maximum diameter at pH 4.1. The size... | [
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PMID:29090 | The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol. | The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol has been assessed using methanol--water mixtures to give a range of surface tensions. The results have been interpreted in terms of the critical surface tension, adhesion tension and spreading coefficients. The critical surface t... | The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol. The wetting of powders of acetylsalicylic acid, salicylic acid, phenacetin and paracetamol has been assessed using methanol--water mixtures to give a range of surface tensions. The results have been interpreted in terms of the c... | [
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PMID:29091 | Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. | Significant correlation in 11 different 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the "azepinones" by sodium borohydride) and their ED50 against leptazol-induced seizures in mice. The results suggest a possible involvement of the carobnyl group at the... | Structure activity relation for some 1,4-benzodiazepinones: correlation between rate constants for reduction by sodium borohydride and antileptazol ED50. Significant correlation in 11 different 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the "azepinones... | [
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PMID:29092 | The use of 13C-nmr spectroscopy for the detection and identification of metabolites of carbon-13 labelled amitriptyline. | The antidepressant drug amitriptyline and two of its metabolites, nortriptyline and desmethylnortriptyline, each containing two 13C atoms, have been used to determine the sensitivity and selectivity of 13C-nmr spectroscopy for the detection of unchanged amitriptyline and N-desmethyl metabolites in the urine of animals ... | The use of 13C-nmr spectroscopy for the detection and identification of metabolites of carbon-13 labelled amitriptyline. The antidepressant drug amitriptyline and two of its metabolites, nortriptyline and desmethylnortriptyline, each containing two 13C atoms, have been used to determine the sensitivity and selectivity ... | [
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PMID:29093 | Acidic in vivo metabolites of cannabinol isolated from rat faeces. | Six acidic metabolites were isolated from rat faeces and identified by gas chromatographymass spectrometry and proton magnetic resonance. Cannabinol-7-oic acid was the most abundant acidic metabolite isolated. Others present in decreasing order of prominence were 1"-hydroxy-, 4"-hydroxy-, 3"-hydroxycannabinol-7-oic aci... | Acidic in vivo metabolites of cannabinol isolated from rat faeces. Six acidic metabolites were isolated from rat faeces and identified by gas chromatographymass spectrometry and proton magnetic resonance. Cannabinol-7-oic acid was the most abundant acidic metabolite isolated. Others present in decreasing order of promi... | [
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PMID:29094 | Comparison between spontaneously beating atria from control and streptozocin-diabetic rats. | Isolated spontaneously beating atria from streptozocin diabetic rats were compared with those from controls. Diabetic atria were found to have reduced rates, increased forces of contraction and reduced sensitivity to the inotropic effects of noradrenaline, isoprenaline, tyramine and calcium. Positive chronotropic respo... | Comparison between spontaneously beating atria from control and streptozocin-diabetic rats. Isolated spontaneously beating atria from streptozocin diabetic rats were compared with those from controls. Diabetic atria were found to have reduced rates, increased forces of contraction and reduced sensitivity to the inotrop... | [
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PMID:29095 | The antitussive actions of the drug Ru 20201 given as an aerosol to cats. | The effect of the drug Ru 20201 (1,2,3,4,4a,9b-hexahydro,-8,9b-dimethyl-4-[3-(4-methylpiperazin-1-yl)propionamido]dibenzofuran-3-one upon mechanically-evoked cough from the laryngopharyngeal and tracheobronchial areas in nine unanaesthetized cats has been examined. Inhalation of 2 ml of an aerosol of a 10% solution in ... | The antitussive actions of the drug Ru 20201 given as an aerosol to cats. The effect of the drug Ru 20201 (1,2,3,4,4a,9b-hexahydro,-8,9b-dimethyl-4-[3-(4-methylpiperazin-1-yl)propionamido]dibenzofuran-3-one upon mechanically-evoked cough from the laryngopharyngeal and tracheobronchial areas in nine unanaesthetized cats... | [
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PMID:29114 | Characterization of pharmacologically important prototropic species derived from a pyridinemethanol antimalarial by electronic absorption and fluorescence spectroscopy. | Variations of the absorption and fluorescence spectra of the experimental antimalarial drug, alpha-dibutylaminomethyl-2,6-bis(p-trifluoromethylphenyl)-4-pyridinemethanol, were investigated throughout the pH region in concentrated sulfuric acid media and in n-hexane. The predominant prototropic species at physiological ... | Characterization of pharmacologically important prototropic species derived from a pyridinemethanol antimalarial by electronic absorption and fluorescence spectroscopy. Variations of the absorption and fluorescence spectra of the experimental antimalarial drug, alpha-dibutylaminomethyl-2,6-bis(p-trifluoromethylphenyl)-... | [
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PMID:29115 | pH-solubility profiles or organic carboxylic acids and their salts. | The solubilities of naproxen, 7-methylsulfinyl-2-xanthonecarboxylic acid, 7-methylthio-2-xanthonecarboxylic acid, and their sodium, potassium, calcium, and magnesium salts were determined as a function of pH. The results on the solubility of naproxen and its salts were in excellent agreement with the theoretical profil... | pH-solubility profiles or organic carboxylic acids and their salts. The solubilities of naproxen, 7-methylsulfinyl-2-xanthonecarboxylic acid, 7-methylthio-2-xanthonecarboxylic acid, and their sodium, potassium, calcium, and magnesium salts were determined as a function of pH. The results on the solubility of naproxen a... | [
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PMID:29117 | Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative. | The synthesis of (+/-)-2-(3'-tert-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole hydrochloride is described. The new compound antagonized the cardiovascular effects, such as positive chronotropic, positive inotropic, or depressor arterial blood pressure responses, elicited by intravenous isoproter... | Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative. The synthesis of (+/-)-2-(3'-tert-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole hydrochloride is described. The new compound antagonized the cardiovascular effects, such as positive chronotropic, positiv... | [
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PMID:29118 | GLC determination of atenolol and beta-blocking agents in biological fluids. | A rapid, sensitive, and specific method of analysis for atenolol is described. Metoprolol is used as the internal standard. Atenolol and metoprolol are extracted into 1-butanol--benzene. Interfering components present in palsma and urine, but not discolored saliva, are removed during an acid wash and reextraction into ... | GLC determination of atenolol and beta-blocking agents in biological fluids. A rapid, sensitive, and specific method of analysis for atenolol is described. Metoprolol is used as the internal standard. Atenolol and metoprolol are extracted into 1-butanol--benzene. Interfering components present in palsma and urine, but ... | [
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PMID:29119 | An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption. | 1. 5-Methyltetrahydrofolic acid transport was studied across everted sacs of rat jejunal segments from control and whole body X-irradiated (700 rad) rats at 10(-5)M concentrations (at which optimum transport occurs) at various pHs.2. The folate transport from mucosal to serosal compartment was inhibited by about 55% in... | An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption. 1. 5-Methyltetrahydrofolic acid transport was studied across everted sacs of rat jejunal segments from control and whole body X-irradiated (700 rad) rats at 10(-5)M concentrations (at which optimum transport occurs) at v... | [
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PMID:29123 | beta-Adrenergic blocking agents. 18. 1-(Aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-ols. | The synthesis is described of a seris of derivaties of 1-(aryloxy)-3-(arylthioalkylamiho)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. These compounds were investigated for their beta-adrenoreceptor blocking properties and their selectivity of action for the cardiac beta1 receptor. ... | beta-Adrenergic blocking agents. 18. 1-(Aryloxy)-3-(arylthioalkylamino)propan-2-ols and 1-substituted alkylthioamino-3-(aryloxy)propan-2-ols. The synthesis is described of a seris of derivaties of 1-(aryloxy)-3-(arylthioalkylamiho)propan-2-ols and 1-(alkylthioamino)- and 1-(aralkylamino)-3-(aryloxy)propan-2-ols. These ... | [
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PMID:29124 | A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics. | The synthesis and stereochemistry of trans-N,N-diethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro[1,4]oxazino[3,4-a]isoquinoline-3-carboxamide hydrochloride (16) and a series of analogues are described. 16 and its (+) isomer had neuroleptic properties in the Sidman avoidance test in gerbils. A few closely related amides of... | A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics. The synthesis and stereochemistry of trans-N,N-diethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro[1,4]oxazino[3,4-a]isoquinoline-3-carboxamide hydrochloride (16) and a series of analogues are described. 16 and its (+) isomer had neuroleptic pr... | [
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PMID:29125 | Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. | The facile syntheses of important intermediates used in the preparation of the two potent dopaminergic argonists, 2-amino-6,7-dihydroxytetrahydronaphthalene (11) (referred to by some authors as ADTN) and its 5,6-dihydroxyl isomer 12, are described. Thus 6,7-dimethyoxy-2-tetralone has been prepared in two steps and 5,6-... | Facile syntheses of potent dopaminergic argonists and their effect on neurotransmitter release. The facile syntheses of important intermediates used in the preparation of the two potent dopaminergic argonists, 2-amino-6,7-dihydroxytetrahydronaphthalene (11) (referred to by some authors as ADTN) and its 5,6-dihydroxyl i... | [
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PMID:29126 | Synthesis and biologic distribution of radioiodinated beta-adrenergic antagonists. | Iodinated analogues 2, 7, and 8 were prepared from propranolol, practolol, and acebutolol in 30--50% yields. Radioisotopic exchange between carrier-free Na125I and the molten iodinated beta-adrenergic antagonist yielded the corresponding 125I-labeled product. The biodistribution in rats, determined at 15 and 60 min pos... | Synthesis and biologic distribution of radioiodinated beta-adrenergic antagonists. Iodinated analogues 2, 7, and 8 were prepared from propranolol, practolol, and acebutolol in 30--50% yields. Radioisotopic exchange between carrier-free Na125I and the molten iodinated beta-adrenergic antagonist yielded the corresponding... | [
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PMID:29132 | The formation of peptides from the 2'(3')-glycyl ester of a nucleotide. | We have synthesized 2'(3')-O-(glycyl)-adenosine-5'-(O-methylphosphate), an analogue of the 3'-terminus of aminoacylated tRNA. A 0.4M solution of this compound maintained at pH 8.2, yields 5.5% of diglycine and 11.5% of diketopiperazine, in addition to the hydrolysis products glycine and adenosine-5'-(O-methylphosphate)... | The formation of peptides from the 2'(3')-glycyl ester of a nucleotide. We have synthesized 2'(3')-O-(glycyl)-adenosine-5'-(O-methylphosphate), an analogue of the 3'-terminus of aminoacylated tRNA. A 0.4M solution of this compound maintained at pH 8.2, yields 5.5% of diglycine and 11.5% of diketopiperazine, in addition... | [
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PMID:29133 | Muscarinic cholinergic activation of mouse spleen cells cytotoxic to tumor cells in vitro. | Carbamylcholine, acting via a pharmacologically specific receptor, had the ability to activate effector populations of spleen cells from female BALB/cfC3H and BALB/c mice; those cell populations were then significantly reactive in vitro against syngeneic tumor target cells but were only minimally reactive to normal syn... | Muscarinic cholinergic activation of mouse spleen cells cytotoxic to tumor cells in vitro. Carbamylcholine, acting via a pharmacologically specific receptor, had the ability to activate effector populations of spleen cells from female BALB/cfC3H and BALB/c mice; those cell populations were then significantly reactive i... | [
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PMID:29134 | Marke's disease herpesviruses. III. Purification and characterization of Marek's disease herpesvirus B antigen. | Sera from chickens naturally infected with Marek's disease herpesvirus (MDHV) form preciptin lines with at least two immunologically distinct soluble antigens designated MDHV-A and MDHV-B. Partial purification and characterization of the glycoprotein MDHV-A antigen was previously reported. MDHV-B was found predominantl... | Marke's disease herpesviruses. III. Purification and characterization of Marek's disease herpesvirus B antigen. Sera from chickens naturally infected with Marek's disease herpesvirus (MDHV) form preciptin lines with at least two immunologically distinct soluble antigens designated MDHV-A and MDHV-B. Partial purificatio... | [
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PMID:29135 | Effects of phosphorylation and pH on the association of NS protein with vesicular stomatitis virus cores. | The proteins of vesicular stomatitis virus (VSV) were analyzed on the basis of charge as well as size in polyacrylamide gels containing urea and acetic acid. The phosphorprotein NS was resolved into two major species. The less phosphorylated NS1 species contained about 10% fewer phosphate residues than the second speci... | Effects of phosphorylation and pH on the association of NS protein with vesicular stomatitis virus cores. The proteins of vesicular stomatitis virus (VSV) were analyzed on the basis of charge as well as size in polyacrylamide gels containing urea and acetic acid. The phosphorprotein NS was resolved into two major speci... | [
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PMID:29137 | Methyprylon-induced bone marrow suppression in siblings. An inherited defect? | Transient bone marrow suppression in two sisters followed ingestion of the sedative-hypnotic drug methyprylon. No other pharmacologic or environmental inciting factor common to both patients was identified. The mechanisms responsible could not be defined; abnormal suppression fo granulocyte progenitors by the drug in v... | Methyprylon-induced bone marrow suppression in siblings. An inherited defect? Transient bone marrow suppression in two sisters followed ingestion of the sedative-hypnotic drug methyprylon. No other pharmacologic or environmental inciting factor common to both patients was identified. The mechanisms responsible could no... | [
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PMID:29142 | Clinical evaluation of a new anticoagulant therapy in prosthetic valve replacement. | Thromboembolic complication was correlated with the methods of anticoagulant therapy used in the patients with Starr-Edwards non cloth-covered or cloth-covered ball valve. A new anticoagulant therapy combining Bucolome with Warfarin has been used for the patients who were unable to be maintained in a suitable range of ... | Clinical evaluation of a new anticoagulant therapy in prosthetic valve replacement. Thromboembolic complication was correlated with the methods of anticoagulant therapy used in the patients with Starr-Edwards non cloth-covered or cloth-covered ball valve. A new anticoagulant therapy combining Bucolome with Warfarin has... | [
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PMID:29155 | Antisecretory effect of imidazole and its derivatives in an isolated gastric mucosa preparation and an anesthetized young chicken preparation; comparison with a histamine H2-receptor antagonist. | We invesigated the influences of imidazole on the basal and the secretagogue-stimulated gastric acid secretion in isolated bullfrog gastric mucosa preparations and in anesthetized young chickens. Imidazoles (1 x 10(-4) g/ml) readily depressed the basal acid secretion in gastric mucosa in vitro. The inhibitory effect of... | Antisecretory effect of imidazole and its derivatives in an isolated gastric mucosa preparation and an anesthetized young chicken preparation; comparison with a histamine H2-receptor antagonist. We invesigated the influences of imidazole on the basal and the secretagogue-stimulated gastric acid secretion in isolated b... | [
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PMID:29161 | Manufacture and utilization of antimony pH electrodes. | A new technique for manufacturing single-barreled and double-barreled antimony pH microelectrodes is described. The results of investigations into the accuracy of antimony as a pH sensor disclosed that the pH-voltage response is: 1) within the physiologic range, principally the result of the hydrogen ion activity of th... | Manufacture and utilization of antimony pH electrodes. A new technique for manufacturing single-barreled and double-barreled antimony pH microelectrodes is described. The results of investigations into the accuracy of antimony as a pH sensor disclosed that the pH-voltage response is: 1) within the physiologic range, pr... | [
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PMID:29168 | Primary malignant melanoma of the small intestine and the APUD cell concept. | A primary melanoma of the small intestine is reported. A possible explanation of its origin according to the APUD cell concept is suggested. This concept may lessen the doubts and confusion whenever an intestinal melanoma is discovered and a primary tumor at one of the more common sites can reasonably be excluded. | Primary malignant melanoma of the small intestine and the APUD cell concept. A primary melanoma of the small intestine is reported. A possible explanation of its origin according to the APUD cell concept is suggested. This concept may lessen the doubts and confusion whenever an intestinal melanoma is discovered and a p... | [
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PMID:29170 | Age-associated changes in glutamine synthetase activity in WI-38 cells. | The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate that glutamine synthetase from younger cell cultures is more heat labile t... | Age-associated changes in glutamine synthetase activity in WI-38 cells. The human fibroblast cell line WI-38 shows a gradual decline in glutamine synthetase specific activity with increasing age in culture. However, the level of functional enzyme per cell does not change with age. Heat inactivation profiles indicate th... | [
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PMID:29171 | Developmental restrictions on hormone modulated gene transcription. II. Hormone induced interactions of RNA polymerase with chromatin. | Chromatin-bound and soluble RNA polymerase subspecies have been isolated and fractionated by isoelectric focusing at various times (0, 6, 12 and 18 h) following auxin treatment of 4 day (responsive) and 8 day (unresponsive) soybean hypocotyls. Young 4 day seedlings displayed two well defined phases of auxin induced gen... | Developmental restrictions on hormone modulated gene transcription. II. Hormone induced interactions of RNA polymerase with chromatin. Chromatin-bound and soluble RNA polymerase subspecies have been isolated and fractionated by isoelectric focusing at various times (0, 6, 12 and 18 h) following auxin treatment of 4 day... | [
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PMID:29219 | Emergence of multiply resistant pneumococci. | Multiple antimicrobial resistance in pneumococci was detected in Johannesburg in July, 1977, and prompted an investigation of the prevalence of resistant strains in two hospitals. Carriers of Types 6A and 19A penicillin-resistant pneumococci, resistant to antibiotic concentrations ranging between 0.12 and 4 microgram p... | Emergence of multiply resistant pneumococci. Multiple antimicrobial resistance in pneumococci was detected in Johannesburg in July, 1977, and prompted an investigation of the prevalence of resistant strains in two hospitals. Carriers of Types 6A and 19A penicillin-resistant pneumococci, resistant to antibiotic concentr... | [
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PMID:29225 | Polygalacturonase, biomass and ascospore production by Byssochlamys fulva. II. Effects of sugars found in fruits. | Polygalacturonase, biomass, and ascospore production by four strains of Byssochlamys fulva cultured in laboratory media supplemented with glucose, sucrose, or fructose was studied over a 20-day incubation period at 30 degrees C. The production of polygalacturonase was variable, but most activity was detected between 4 ... | Polygalacturonase, biomass and ascospore production by Byssochlamys fulva. II. Effects of sugars found in fruits. Polygalacturonase, biomass, and ascospore production by four strains of Byssochlamys fulva cultured in laboratory media supplemented with glucose, sucrose, or fructose was studied over a 20-day incubation p... | [
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PMID:29226 | The distribution of geophilic dermatophytes in Kenyan soils. | Two hundred and eighty one soil samples from different provinces of Kenya were examined for dermatophytes by the hair baiting technique. Dermatophytes were recovered from 84 samples. Microsporum gypseum constituted 75.8% of the total isolates while Keratinomyces ajelloi and M. cookei formed 21% and 3.2%, respectively. ... | The distribution of geophilic dermatophytes in Kenyan soils. Two hundred and eighty one soil samples from different provinces of Kenya were examined for dermatophytes by the hair baiting technique. Dermatophytes were recovered from 84 samples. Microsporum gypseum constituted 75.8% of the total isolates while Keratinomy... | [
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PMID:29227 | Mycological profile of crew during 56-day simulated orbital flight. | Mycological analyses were made on specimens obtained from the skin, oral rinse, urine, and feces of three subjects participating in a 56 day Skylab simulation test. Samples were taken over a 175 day period divided into three phases consisting of a prechamber, intrachamber, and postchamber period. A total of 69 species ... | Mycological profile of crew during 56-day simulated orbital flight. Mycological analyses were made on specimens obtained from the skin, oral rinse, urine, and feces of three subjects participating in a 56 day Skylab simulation test. Samples were taken over a 175 day period divided into three phases consisting of a prec... | [
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PMID:29245 | Experiments to increase the selectivity of tumor chemotherapy by means of in vivo activation of transport forms of cancerostatics by exogenous enzymes. | A significant tumor damaging effect (growth inhibition) on transplanted syngeneic sarcoma in mouse was obtained by means of pH-dependent activation of a transport form of a cancerostatic drug by an enzyme foreign to the organism. This effect was achieved by combined administration of 8-0-(alpha-L-arabinofuranosyl)beta-... | Experiments to increase the selectivity of tumor chemotherapy by means of in vivo activation of transport forms of cancerostatics by exogenous enzymes. A significant tumor damaging effect (growth inhibition) on transplanted syngeneic sarcoma in mouse was obtained by means of pH-dependent activation of a transport form ... | [
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... |
PMID:29246 | [Neuroleptics with prolonged action]. | In the last twenty years, the study of long-acting neuroleptic drugs has been active and promising progress in maintenance of psychotic patients. At present, there are several long-acting derivatives of phenothiazines, e.g. thioridazine, or drugs that allow the esterification of phenothiazine, e.g. perphenazine, fluphe... | [Neuroleptics with prolonged action]. In the last twenty years, the study of long-acting neuroleptic drugs has been active and promising progress in maintenance of psychotic patients. At present, there are several long-acting derivatives of phenothiazines, e.g. thioridazine, or drugs that allow the esterification of ph... | [
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PMID:29249 | [Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam]. | 48 patients with several types of seizures (following the international classification of epileptic seizures), were studied. Dipotassium chlorazepate was administered as a secondary antiepileptic drug. The cases were selected due to the severity of their seizures. The therapeutic results were evaluated with a daily rec... | [Treatment of epileptic crisis with chlorazepate dipotassium. Clinical study of 48 patients with the determination of serum levels of nordiazepam]. 48 patients with several types of seizures (following the international classification of epileptic seizures), were studied. Dipotassium chlorazepate was administered as a ... | [
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PMID:29261 | [Study of the antispastic activity of prifinium bromide in motor dysfunction of the esophagus]. | Motor disturbances of the oesophagus are attributable to hypermotility or hypomotility, or to peristaltic uncoordination of the upper or lower sphincter, or of the corpus. Endoesophageal manometry has enabled considerable progress to be made in the study of oesophageal dysfunction by allowing the spasm to be quantified... | [Study of the antispastic activity of prifinium bromide in motor dysfunction of the esophagus]. Motor disturbances of the oesophagus are attributable to hypermotility or hypomotility, or to peristaltic uncoordination of the upper or lower sphincter, or of the corpus. Endoesophageal manometry has enabled considerable pr... | [
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PMID:29265 | [Effect of mouse age on the ability of hematopoietic stem cells to interact with thymus cells]. | The effect of the thymus cells of the C57BL/6 mice on the colony forming ability of the stem hemopoietic cells of the embryonic liver and bone marrow of young (3 months) and old (2 years) mice was studied their joint transplantation into the mice (CBAXXC57BL/6) F1. The stimulating effect of the thymus cells on the colo... | [Effect of mouse age on the ability of hematopoietic stem cells to interact with thymus cells]. The effect of the thymus cells of the C57BL/6 mice on the colony forming ability of the stem hemopoietic cells of the embryonic liver and bone marrow of young (3 months) and old (2 years) mice was studied their joint transpl... | [
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PMID:29266 | [Relationship between hematopoietic stem differentiation and the functional state of the thymus]. | The direction of differentiation of the stem cells with respect to the physiological activity of thymus determined by the age of an animal was studied by means of histological analysis of hemopoietic colonies in the spleen of lethally irradiated mice. The immaturity of thymus of its involution are characterized by the ... | [Relationship between hematopoietic stem differentiation and the functional state of the thymus]. The direction of differentiation of the stem cells with respect to the physiological activity of thymus determined by the age of an animal was studied by means of histological analysis of hemopoietic colonies in the spleen... | [
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PMID:29274 | Takayasu arteritis and renovascular hypertension in childhood. | Takayasu arteritis with renal artery involvement was the cause of severe persistent hypertension in eight children under 12 years of age. Features of severe hypertension dominated the clinical picture. Unequal or absent pulses were found in three patients. An irregular contour of the descending thoracic aorta on the ch... | Takayasu arteritis and renovascular hypertension in childhood. Takayasu arteritis with renal artery involvement was the cause of severe persistent hypertension in eight children under 12 years of age. Features of severe hypertension dominated the clinical picture. Unequal or absent pulses were found in three patients. ... | [
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PMID:29277 | The response of lymphatic smooth muscles to vasoactive substances. | A study was made of the isotonic response of bovine mesenteric lymphatics to several physiological vasoactive substances. Contractions of lymphatic smooth muscles were induced by serotonin (5-HT), prostaglandin F2alpha (PGF2alpha), noradrenaline (NA), histamine, dopamine and acetylcholine (ACh). The smooth muscles were... | The response of lymphatic smooth muscles to vasoactive substances. A study was made of the isotonic response of bovine mesenteric lymphatics to several physiological vasoactive substances. Contractions of lymphatic smooth muscles were induced by serotonin (5-HT), prostaglandin F2alpha (PGF2alpha), noradrenaline (NA), h... | [
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PMID:29278 | High pyruvate kinase activity causes low concentration of 2,3-diphosphoglycerate in fetal rabbit red cells. | 1. The high oxygen affinity of fetal blood in rabbits is due to a very low concentration of 2,3-diphosphoglycerate (2,3-DPG) in the red cells. In order to gather informations on the factors responsible for this characteristic we have studied synthesis and break-down of 2,3-DPG in fetal and adult rabbit red cells in vit... | High pyruvate kinase activity causes low concentration of 2,3-diphosphoglycerate in fetal rabbit red cells. 1. The high oxygen affinity of fetal blood in rabbits is due to a very low concentration of 2,3-diphosphoglycerate (2,3-DPG) in the red cells. In order to gather informations on the factors responsible for this c... | [
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PMID:29279 | Cooperation of peripheral and central chemosensitive mechanisms in the control of the extracellular pH in brain in non-respiratory acidosis. | The mathematical model of the respiratory control system in man of Middendorf and Loeschcke (1976 a, b) opens the possibility to stimulate the constellation of parameters in non-respiratory acidosis. Several investigators agree that the pH in CSF or in the extracellular fluid of the brain stays remarkably constant in t... | Cooperation of peripheral and central chemosensitive mechanisms in the control of the extracellular pH in brain in non-respiratory acidosis. The mathematical model of the respiratory control system in man of Middendorf and Loeschcke (1976 a, b) opens the possibility to stimulate the constellation of parameters in non-r... | [
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PMID:29281 | Purification and properties of DNA-dependent DNA-polymerases from Neurospora crassa. | Two DNA-dependent DNA-polymerases (E.C. 2.7.7.7) are partially purified from the high speed supernatant of mechanically disrupted hyphae of Neurospora crassa WT 74A. Some properties such as temperature and pH optimum and theoptimal concentrations for Mg2+, Zn2+, NH4+ and Na+ are very similar. On the other hand these en... | Purification and properties of DNA-dependent DNA-polymerases from Neurospora crassa. Two DNA-dependent DNA-polymerases (E.C. 2.7.7.7) are partially purified from the high speed supernatant of mechanically disrupted hyphae of Neurospora crassa WT 74A. Some properties such as temperature and pH optimum and theoptimal con... | [
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PMID:29290 | Observations on vascular neuropathies. | A series of autopsy studies is presented of 13 cases of obliterative vascular disease of the vasa nervorum in a wide range of conditions, including polyarteritis nodosa, Wegener's granulomatosis, lymphomatoid granulomatosis, polymyositis and rheumatoid arthritis. In most cases, including 1 of rheumatoid neuropathy, the... | Observations on vascular neuropathies. A series of autopsy studies is presented of 13 cases of obliterative vascular disease of the vasa nervorum in a wide range of conditions, including polyarteritis nodosa, Wegener's granulomatosis, lymphomatoid granulomatosis, polymyositis and rheumatoid arthritis. In most cases, in... | [
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PMID:29291 | Correlation of the biological activity and solution conformation of [Asp1,Ile5]- and [Phe4,Tyr8]angiotensin II. | Angiotensin II is known to undergo a reversible conformational transition and a change in potency in rat uterus in vitro with pK approximately 6.5. We have shown by carbon-13 NMR that the conformational transition involves all-trans to partly cis isomerization of the His6-Pro7 peptide bond. Isomerization from all-trans... | Correlation of the biological activity and solution conformation of [Asp1,Ile5]- and [Phe4,Tyr8]angiotensin II. Angiotensin II is known to undergo a reversible conformational transition and a change in potency in rat uterus in vitro with pK approximately 6.5. We have shown by carbon-13 NMR that the conformational trans... | [
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PMID:29292 | Role of a transmembrane pH gradient in epinephrine transport by chromaffin granule membrane vesicles. | ATP-driven transport and accumulation of epinephrine in chromaffin granule membrane vesicles isolated from bovine adrenal medulla is inhibited by the proton ionophores carbonylcyanide p-trifluoromethoxyphenylhydrazone and nigericin, but not by valinomycin. Moreover, an artificially imposed pH gradient (interior acid) i... | Role of a transmembrane pH gradient in epinephrine transport by chromaffin granule membrane vesicles. ATP-driven transport and accumulation of epinephrine in chromaffin granule membrane vesicles isolated from bovine adrenal medulla is inhibited by the proton ionophores carbonylcyanide p-trifluoromethoxyphenylhydrazone ... | [
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PMID:29293 | Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue. | Glucocerebrosidase was purified 26,000-fold from spleens from normal humans and from patients with Gaucher disease (Gaucher spleens). The specific activities of the purified normal and mutant enzymes with glucocerebroside as substrate were 8.5 X 10(5) and 5.4 X 10(4) nmol/mg of protein per hr, respectively. The ratio o... | Gaucher disease: isolation and comparison of normal and mutant glucocerebrosidase from human spleen tissue. Glucocerebrosidase was purified 26,000-fold from spleens from normal humans and from patients with Gaucher disease (Gaucher spleens). The specific activities of the purified normal and mutant enzymes with glucoce... | [
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PMID:29313 | Potentiation by neuroleptic agents of the inhibitory action of intraperitoneally administered GABA on the locomotor activity of mice. | The ability of several neuroleptics to potentiate the inhibitory action of IP administered GABA on the motor activity of mice has been investigated. Haloperidol, chlorpromazine, thioridazine, and clozapine, but not the apparently selective dopamine receptor-blocking agent spiperone, were found to possess such activity.... | Potentiation by neuroleptic agents of the inhibitory action of intraperitoneally administered GABA on the locomotor activity of mice. The ability of several neuroleptics to potentiate the inhibitory action of IP administered GABA on the motor activity of mice has been investigated. Haloperidol, chlorpromazine, thiorida... | [
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PMID:29315 | A new putative neuroregulator of the extrapyramidal system. | A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after catecholamine depletion by pretreatment with a-methyl-para-t... | A new putative neuroregulator of the extrapyramidal system. A putative neurotransmitter, 2-phenylethylamine, which is most highly concentrated in the extrapyramidal system of human brain, is able to reverse reserpine-induced parkinsonism in animals and elicit stereotypy. This action is only partially antagonized after ... | [
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PMID:29316 | The isolated nictitating membrane of the cat. A new model for the study of narcotic analgesics. | Kinetic parameters of morphine and azidomorphine derivatives as well as methionine enkephalin methylester were determined on the electrically stimulated isolated medial smooth muscle of the cat nictitating membrane. The organ was found to be a promising in vitro model for testing the action of opiate agonists on opiate... | The isolated nictitating membrane of the cat. A new model for the study of narcotic analgesics. Kinetic parameters of morphine and azidomorphine derivatives as well as methionine enkephalin methylester were determined on the electrically stimulated isolated medial smooth muscle of the cat nictitating membrane. The orga... | [
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PMID:29320 | Chemical stability of prostacyclin (PGI2) in aqueous solutions. | The rate constant for the hydrolysis of prostacyclin (PGI2) to 6-keto-PGF1alpha was measured by monitoring the UV spectral change, over a pH range 6 to 10 at 25 degrees C and the total ionic strength of 0.5 M. The first-order rate constant (kdegreesobs) extrapolated to zero buffer concentration follows an expression, k... | Chemical stability of prostacyclin (PGI2) in aqueous solutions. The rate constant for the hydrolysis of prostacyclin (PGI2) to 6-keto-PGF1alpha was measured by monitoring the UV spectral change, over a pH range 6 to 10 at 25 degrees C and the total ionic strength of 0.5 M. The first-order rate constant (kdegreesobs) ex... | [
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PMID:29326 | Retained inhibition of the beta receptor by propranolol after preincubation and washout. | Mouse thymus cells possess a B2-adrenergic receptor and, when centrifuged through a solution of propanolol at 5 degrees and washed three times, will produce reduced amounts of cyclic AMP during a 5 minute challenge with isoproterenol at room temperature. Depending on the concentration and nature of the antagonist, the ... | Retained inhibition of the beta receptor by propranolol after preincubation and washout. Mouse thymus cells possess a B2-adrenergic receptor and, when centrifuged through a solution of propanolol at 5 degrees and washed three times, will produce reduced amounts of cyclic AMP during a 5 minute challenge with isoproteren... | [
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PMID:29327 | Effect of benzodiazepine derivatives on human blood cholinesterase in vitro. | The in vitro effect of ten benzodiazepine derivatives on the cholinesterases of human plasma and red cells was determined. Flurazepam, temazepam, lorazepam, flunitrazepam and diazepam had an inhibitory effect on plasma cholinesterase of 60--90 per cent and, with the exception of lorazepam, an inhibitory effect of 40--5... | Effect of benzodiazepine derivatives on human blood cholinesterase in vitro. The in vitro effect of ten benzodiazepine derivatives on the cholinesterases of human plasma and red cells was determined. Flurazepam, temazepam, lorazepam, flunitrazepam and diazepam had an inhibitory effect on plasma cholinesterase of 60--90... | [
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PMID:29330 | [Physiological trials with MIF-I in Parkinson's disease (author's transl)]. | The writers present some physiological (and not therapeutic) acute and sub-acute trials with tripeptide: L-propyl-L-leucyl-glycine amide (M.I.F.-I) in Parkinson's Disease. This work confirms the earlier observation that M.I.F.-I employed alone or in combination with Levodopa is active against Parkinson's disease. The w... | [Physiological trials with MIF-I in Parkinson's disease (author's transl)]. The writers present some physiological (and not therapeutic) acute and sub-acute trials with tripeptide: L-propyl-L-leucyl-glycine amide (M.I.F.-I) in Parkinson's Disease. This work confirms the earlier observation that M.I.F.-I employed alone ... | [
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PMID:29337 | [Neuroleptics and sexual dysfunction in man. Neuroendocrine aspects]. | Sexual behaviour and fertility of schizophrenic patients are discussed. The various sexual dysfunctions induced by neuroleptics, such as decrease in libido, troubles of ejaculation and impotence, are described and related to their various mechanisms of action. The central antidopaminergic effect of neuroleptics would b... | [Neuroleptics and sexual dysfunction in man. Neuroendocrine aspects]. Sexual behaviour and fertility of schizophrenic patients are discussed. The various sexual dysfunctions induced by neuroleptics, such as decrease in libido, troubles of ejaculation and impotence, are described and related to their various mechanisms ... | [
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PMID:29334 | Lymphocyte changes after long-term therapy of some neurological diseases. | Hematologic investigations were carried out in 50 patients with various forms of epilepsy, aged 20 to 50 years, who had been treated for different periods of time with antiepileptic and neuroleptic drugs such as primidon, luminal and prasine. All the cytomorphological and cytochemical studies concerned the white blood ... | Lymphocyte changes after long-term therapy of some neurological diseases. Hematologic investigations were carried out in 50 patients with various forms of epilepsy, aged 20 to 50 years, who had been treated for different periods of time with antiepileptic and neuroleptic drugs such as primidon, luminal and prasine. All... | [
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PMID:29338 | [Histamine H-2 receptor antagonists and medical treatment of Zollinger-Ellison syndrome]. | Cimetidine was studied in 8 cases of Zollinger-Ellison syndrome. The average dose was 1,2 g a day for 14 to 195 days. The treatment was remarkably effective in 2 cases, but only partial or temporary improvement was noted in 3 other cases. The last 3 patients failed to respond to treatment. The possibility of a rebound ... | [Histamine H-2 receptor antagonists and medical treatment of Zollinger-Ellison syndrome]. Cimetidine was studied in 8 cases of Zollinger-Ellison syndrome. The average dose was 1,2 g a day for 14 to 195 days. The treatment was remarkably effective in 2 cases, but only partial or temporary improvement was noted in 3 othe... | [
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PMID:29340 | Small cell carcinoma of the lung: cellular origin and relationship to other neoplasms. | Many small cell carcinomas share morphological and physiological characteristics with normal and neoplastic cells of Pearse's APUD series, including pulmonary APUD cells and pulmonary carcinoid tumors. There is very likely more than one type of APUD cell in the lung, and conclusions that small cell carcinomas and carci... | Small cell carcinoma of the lung: cellular origin and relationship to other neoplasms. Many small cell carcinomas share morphological and physiological characteristics with normal and neoplastic cells of Pearse's APUD series, including pulmonary APUD cells and pulmonary carcinoid tumors. There is very likely more than ... | [
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PMID:29343 | Maternal blood gas status of four racial groups in late pregnancy A preliminary study. | The blood gas/acid-base status of normal healthy Black, Indian, Coloured and White pregnant women was measured. All groups exhibited evidence of hyperventilation (decreased) PaCO2 relative to the non-pregnant state, with compensatory metabolic adjustment. Arterial oxygen tensions (PaO2) were significantly lower in the ... | Maternal blood gas status of four racial groups in late pregnancy A preliminary study. The blood gas/acid-base status of normal healthy Black, Indian, Coloured and White pregnant women was measured. All groups exhibited evidence of hyperventilation (decreased) PaCO2 relative to the non-pregnant state, with compensatory... | [
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PMID:29347 | Antacid properties of a sodium citrate preparation. | A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant n... | Antacid properties of a sodium citrate preparation. A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gast... | [
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PMID:29348 | Assessment of a diagnostic dip-stick for assaying plasma or serum pseudocholinesterase activity. | A diagnostic dip-stick for measuring pseudocholinesterase activity has been assessed by 4 participants and compared with a standard spectrophotometric method. Duplicate dip-stick estimations (measured in kU/l) corresponded closely, and concurrence between participants was good. The dip-stick estimate of cholinesterase ... | Assessment of a diagnostic dip-stick for assaying plasma or serum pseudocholinesterase activity. A diagnostic dip-stick for measuring pseudocholinesterase activity has been assessed by 4 participants and compared with a standard spectrophotometric method. Duplicate dip-stick estimations (measured in kU/l) corresponded ... | [
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PMID:29349 | Clinical usefulness of the beta-adrenergic antagonists. | The pharmacology of the beta-adrenergic antagonists, particularly their role as competitive antagonists at the receptor site, is discussed. The clinical use of these agents is listed and a detailed outline of their use in angina pectoris, hypertension and conditions associated with increased sympathetic activity is pro... | Clinical usefulness of the beta-adrenergic antagonists. The pharmacology of the beta-adrenergic antagonists, particularly their role as competitive antagonists at the receptor site, is discussed. The clinical use of these agents is listed and a detailed outline of their use in angina pectoris, hypertension and conditio... | [
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... |
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